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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:CUX1-EHBP1L1 (FusionGDB2 ID:20724)

Fusion Gene Summary for CUX1-EHBP1L1

check button Fusion gene summary
Fusion gene informationFusion gene name: CUX1-EHBP1L1
Fusion gene ID: 20724
HgeneTgene
Gene symbol

CUX1

EHBP1L1

Gene ID

1523

254102

Gene namecut like homeobox 1EH domain binding protein 1 like 1
SynonymsCASP|CDP|CDP/Cut|CDP1|COY1|CUTL1|CUX|Clox|Cux/CDP|GDDI|GOLIM6|Nbla10317|p100|p110|p200|p75-
Cytomap

7q22.1

11q13.1

Type of geneprotein-codingprotein-coding
Descriptionprotein CASPHomeobox protein cut-like 1CCAAT displacement proteinCUX1 gene Alternatively Spliced Productcut homologgolgi integral membrane protein 6homeobox protein cux-1putative protein product of Nbla10317EH domain-binding protein 1-like protein 1tangerin
Modification date2020032020200313
UniProtAcc

P39880

Q8N3D4

Ensembl transtripts involved in fusion geneENST00000437600, ENST00000292538, 
ENST00000393824, ENST00000547394, 
ENST00000360264, ENST00000425244, 
ENST00000292535, ENST00000549414, 
ENST00000556210, ENST00000550008, 
ENST00000546411, ENST00000560541, 
ENST00000309295, ENST00000529596, 
ENST00000533364, 
Fusion gene scores* DoF score32 X 26 X 13=108167 X 7 X 4=196
# samples 377
** MAII scorelog2(37/10816*10)=-4.86949797576587
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CUX1 [Title/Abstract] AND EHBP1L1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCUX1(101459373)-EHBP1L1(65351712), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CUX1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across EHBP1L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-37-4132-01ACUX1chr7

101459373

+EHBP1L1chr11

65351712

+
ChimerDB4LUSCTCGA-37-4132-01ACUX1chr7

101459373

-EHBP1L1chr11

65351712

+


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Fusion Gene ORF analysis for CUX1-EHBP1L1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000437600ENST00000309295CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
5CDS-intronENST00000437600ENST00000529596CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
5CDS-intronENST00000437600ENST00000533364CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
In-frameENST00000292538ENST00000309295CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
5CDS-intronENST00000292538ENST00000529596CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
5CDS-intronENST00000292538ENST00000533364CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
In-frameENST00000393824ENST00000309295CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
5CDS-intronENST00000393824ENST00000529596CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
5CDS-intronENST00000393824ENST00000533364CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
In-frameENST00000547394ENST00000309295CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
5CDS-intronENST00000547394ENST00000529596CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
5CDS-intronENST00000547394ENST00000533364CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
In-frameENST00000360264ENST00000309295CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
5CDS-intronENST00000360264ENST00000529596CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
5CDS-intronENST00000360264ENST00000533364CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
In-frameENST00000425244ENST00000309295CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
5CDS-intronENST00000425244ENST00000529596CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
5CDS-intronENST00000425244ENST00000533364CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
intron-3CDSENST00000292535ENST00000309295CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
intron-intronENST00000292535ENST00000529596CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
intron-intronENST00000292535ENST00000533364CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
intron-3CDSENST00000549414ENST00000309295CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
intron-intronENST00000549414ENST00000529596CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
intron-intronENST00000549414ENST00000533364CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
intron-3CDSENST00000556210ENST00000309295CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
intron-intronENST00000556210ENST00000529596CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
intron-intronENST00000556210ENST00000533364CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
intron-3CDSENST00000550008ENST00000309295CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
intron-intronENST00000550008ENST00000529596CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
intron-intronENST00000550008ENST00000533364CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
intron-3CDSENST00000546411ENST00000309295CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
intron-intronENST00000546411ENST00000529596CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
intron-intronENST00000546411ENST00000533364CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
intron-3CDSENST00000560541ENST00000309295CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
intron-intronENST00000560541ENST00000529596CUX1chr7

101459373

+EHBP1L1chr11

65351712

+
intron-intronENST00000560541ENST00000533364CUX1chr7

101459373

+EHBP1L1chr11

65351712

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000437600CUX1chr7101459373+ENST00000309295EHBP1L1chr1165351712+22424153521893513
ENST00000292538CUX1chr7101459373+ENST00000309295EHBP1L1chr1165351712+191689261567513
ENST00000393824CUX1chr7101459373+ENST00000309295EHBP1L1chr1165351712+191386231564513
ENST00000547394CUX1chr7101459373+ENST00000309295EHBP1L1chr1165351712+191285221563513
ENST00000360264CUX1chr7101459373+ENST00000309295EHBP1L1chr1165351712+191083201561513
ENST00000425244CUX1chr7101459373+ENST00000309295EHBP1L1chr1165351712+190073101551513

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000437600ENST00000309295CUX1chr7101459373+EHBP1L1chr1165351712+0.0121824920.9878176
ENST00000292538ENST00000309295CUX1chr7101459373+EHBP1L1chr1165351712+0.0206816350.9793184
ENST00000393824ENST00000309295CUX1chr7101459373+EHBP1L1chr1165351712+0.0209892620.9790107
ENST00000547394ENST00000309295CUX1chr7101459373+EHBP1L1chr1165351712+0.0209221490.9790779
ENST00000360264ENST00000309295CUX1chr7101459373+EHBP1L1chr1165351712+0.0214993790.97850066
ENST00000425244ENST00000309295CUX1chr7101459373+EHBP1L1chr1165351712+0.021472180.97852784

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Fusion Genomic Features for CUX1-EHBP1L1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CUX1chr7101459373+EHBP1L1chr1165351711+0.0012384750.99876153
CUX1chr7101459373+EHBP1L1chr1165351711+0.0012384750.99876153

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CUX1-EHBP1L1


check button Go to

FGviewer for the breakpoints of chr7:101459373-chr11:65351712

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CUX1

P39880

EHBP1L1

Q8N3D4

FUNCTION: Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000269|PubMed:15099520}.FUNCTION: May act as Rab effector protein and play a role in vesicle trafficking. {ECO:0000305|PubMed:27552051}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEHBP1L1chr7:101459373chr11:65351712ENST000003092958191363_15151031.01524.0Coiled coilOntology_term=ECO:0000255
TgeneEHBP1L1chr7:101459373chr11:65351712ENST000003092958191153_11581031.01524.0Compositional biasNote=Poly-Gly
TgeneEHBP1L1chr7:101459373chr11:65351712ENST000003092958191247_12501031.01524.0Compositional biasNote=Poly-Gly
TgeneEHBP1L1chr7:101459373chr11:65351712ENST000003092958191308_13111031.01524.0Compositional biasNote=Poly-Ala
TgeneEHBP1L1chr7:101459373chr11:65351712ENST000003092958191316_13471031.01524.0Compositional biasNote=Pro-rich
TgeneEHBP1L1chr7:101459373chr11:65351712ENST000003092958191037_11421031.01524.0DomainCalponin-homology (CH)
TgeneEHBP1L1chr7:101459373chr11:65351712ENST000003092958191349_15011031.01524.0DomainbMERB
TgeneEHBP1L1chr7:101459373chr11:65351712ENST000003092958191520_15231031.01524.0MotifCAAX motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCUX1chr7:101459373chr11:65351712ENST00000292535+12456_40701506.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr11:65351712ENST00000292538+123502_55621.0679.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr11:65351712ENST00000292538+12367_45021.0679.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr11:65351712ENST00000360264+12456_40721.01517.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr11:65351712ENST00000393824+122502_55621.0640.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr11:65351712ENST00000393824+12267_45021.0640.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr11:65351712ENST00000425244+12256_40721.0633.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr11:65351712ENST00000437600+123502_55621.0677.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr11:65351712ENST00000437600+12367_45021.0677.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr11:65351712ENST00000546411+12456_4070.01404.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr11:65351712ENST00000547394+122502_55621.0663.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr11:65351712ENST00000547394+12267_45021.0663.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr11:65351712ENST00000549414+12356_4070.01484.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr11:65351712ENST00000550008+12256_4070.01450.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr11:65351712ENST00000556210+12256_4070.01348.0Coiled coilOntology_term=ECO:0000255
HgeneCUX1chr7:101459373chr11:65351712ENST00000292535+1241406_143801506.0Compositional biasNote=Ala-rich
HgeneCUX1chr7:101459373chr11:65351712ENST00000360264+1241406_143821.01517.0Compositional biasNote=Ala-rich
HgeneCUX1chr7:101459373chr11:65351712ENST00000425244+1221406_143821.0633.0Compositional biasNote=Ala-rich
HgeneCUX1chr7:101459373chr11:65351712ENST00000546411+1241406_14380.01404.0Compositional biasNote=Ala-rich
HgeneCUX1chr7:101459373chr11:65351712ENST00000549414+1231406_14380.01484.0Compositional biasNote=Ala-rich
HgeneCUX1chr7:101459373chr11:65351712ENST00000550008+1221406_14380.01450.0Compositional biasNote=Ala-rich
HgeneCUX1chr7:101459373chr11:65351712ENST00000556210+1221406_14380.01348.0Compositional biasNote=Ala-rich
HgeneCUX1chr7:101459373chr11:65351712ENST00000292535+1241117_120401506.0DNA bindingCUT 3
HgeneCUX1chr7:101459373chr11:65351712ENST00000292535+1241244_130301506.0DNA bindingHomeobox
HgeneCUX1chr7:101459373chr11:65351712ENST00000292535+124542_62901506.0DNA bindingCUT 1
HgeneCUX1chr7:101459373chr11:65351712ENST00000292535+124934_102101506.0DNA bindingCUT 2
HgeneCUX1chr7:101459373chr11:65351712ENST00000360264+1241117_120421.01517.0DNA bindingCUT 3
HgeneCUX1chr7:101459373chr11:65351712ENST00000360264+1241244_130321.01517.0DNA bindingHomeobox
HgeneCUX1chr7:101459373chr11:65351712ENST00000360264+124542_62921.01517.0DNA bindingCUT 1
HgeneCUX1chr7:101459373chr11:65351712ENST00000360264+124934_102121.01517.0DNA bindingCUT 2
HgeneCUX1chr7:101459373chr11:65351712ENST00000425244+1221117_120421.0633.0DNA bindingCUT 3
HgeneCUX1chr7:101459373chr11:65351712ENST00000425244+1221244_130321.0633.0DNA bindingHomeobox
HgeneCUX1chr7:101459373chr11:65351712ENST00000425244+122542_62921.0633.0DNA bindingCUT 1
HgeneCUX1chr7:101459373chr11:65351712ENST00000425244+122934_102121.0633.0DNA bindingCUT 2
HgeneCUX1chr7:101459373chr11:65351712ENST00000546411+1241117_12040.01404.0DNA bindingCUT 3
HgeneCUX1chr7:101459373chr11:65351712ENST00000546411+1241244_13030.01404.0DNA bindingHomeobox
HgeneCUX1chr7:101459373chr11:65351712ENST00000546411+124542_6290.01404.0DNA bindingCUT 1
HgeneCUX1chr7:101459373chr11:65351712ENST00000546411+124934_10210.01404.0DNA bindingCUT 2
HgeneCUX1chr7:101459373chr11:65351712ENST00000549414+1231117_12040.01484.0DNA bindingCUT 3
HgeneCUX1chr7:101459373chr11:65351712ENST00000549414+1231244_13030.01484.0DNA bindingHomeobox
HgeneCUX1chr7:101459373chr11:65351712ENST00000549414+123542_6290.01484.0DNA bindingCUT 1
HgeneCUX1chr7:101459373chr11:65351712ENST00000549414+123934_10210.01484.0DNA bindingCUT 2
HgeneCUX1chr7:101459373chr11:65351712ENST00000550008+1221117_12040.01450.0DNA bindingCUT 3
HgeneCUX1chr7:101459373chr11:65351712ENST00000550008+1221244_13030.01450.0DNA bindingHomeobox
HgeneCUX1chr7:101459373chr11:65351712ENST00000550008+122542_6290.01450.0DNA bindingCUT 1
HgeneCUX1chr7:101459373chr11:65351712ENST00000550008+122934_10210.01450.0DNA bindingCUT 2
HgeneCUX1chr7:101459373chr11:65351712ENST00000556210+1221117_12040.01348.0DNA bindingCUT 3
HgeneCUX1chr7:101459373chr11:65351712ENST00000556210+1221244_13030.01348.0DNA bindingHomeobox
HgeneCUX1chr7:101459373chr11:65351712ENST00000556210+122542_6290.01348.0DNA bindingCUT 1
HgeneCUX1chr7:101459373chr11:65351712ENST00000556210+122934_10210.01348.0DNA bindingCUT 2
HgeneCUX1chr7:101459373chr11:65351712ENST00000292538+1231_61921.0679.0Topological domainCytoplasmic
HgeneCUX1chr7:101459373chr11:65351712ENST00000292538+123641_67821.0679.0Topological domainLumenal
HgeneCUX1chr7:101459373chr11:65351712ENST00000393824+1221_61921.0640.0Topological domainCytoplasmic
HgeneCUX1chr7:101459373chr11:65351712ENST00000393824+122641_67821.0640.0Topological domainLumenal
HgeneCUX1chr7:101459373chr11:65351712ENST00000437600+1231_61921.0677.0Topological domainCytoplasmic
HgeneCUX1chr7:101459373chr11:65351712ENST00000437600+123641_67821.0677.0Topological domainLumenal
HgeneCUX1chr7:101459373chr11:65351712ENST00000547394+1221_61921.0663.0Topological domainCytoplasmic
HgeneCUX1chr7:101459373chr11:65351712ENST00000547394+122641_67821.0663.0Topological domainLumenal
HgeneCUX1chr7:101459373chr11:65351712ENST00000292538+123620_64021.0679.0TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneCUX1chr7:101459373chr11:65351712ENST00000393824+122620_64021.0640.0TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneCUX1chr7:101459373chr11:65351712ENST00000437600+123620_64021.0677.0TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneCUX1chr7:101459373chr11:65351712ENST00000547394+122620_64021.0663.0TransmembraneHelical%3B Anchor for type IV membrane protein
TgeneEHBP1L1chr7:101459373chr11:65351712ENST00000309295819222_2261031.01524.0Compositional biasNote=Poly-Glu
TgeneEHBP1L1chr7:101459373chr11:65351712ENST00000309295819561_8901031.01524.0Compositional biasNote=Glu-rich
TgeneEHBP1L1chr7:101459373chr11:65351712ENST000003092958198_1571031.01524.0DomainC2 NT-type


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Fusion Gene Sequence for CUX1-EHBP1L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000437600_ENST00000309295_TCGA-37-4132-01A_CUX1_chr7_101459373_+_EHBP1L1_chr11_65351712_length(transcript)=2242nt_BP=415nt
TGGCCGGCGCGACCGCGGACTTTGGGGGGGGTTGTCCCGAGGGGCGGGGGTCGCCGGTCGGCCCGCGGAGGGGAGGGGGAGGGCGGCGGT
GGGGGGGTTGGGGGAGCAGGGGCCGGGGCCGCGCGCGCGAGGCCGGGCCGCGGCCGCCGCGCCCTGGGGCTGCGACTCCGGCTCCGGCTC
GGGCTCGCCATGGCTGCGGCGGTGCCGTGAGGAGGAGTCCGCGTCCTCGGTGGCGGCGGCGGCGGCCGGCTCCAGGCCGGGTTTTGGCGC
CGCCCGCCTGCTGCCTCCTGGCGGCTCCTGAACTCCAGCCCCCTCTCTATCAGCCGCTCACTCCGTCTCAATATGTCTCAAGATGGCGGC
CAATGTGGGATCGATGTTTCAATATTGGAAGCGCTTTGATTTACAGCAGCTGCAGGCACCACCTGCCCTGGTCAGCTCCAGCCAGTCCCT
GCTGGAGTGGTGCCAGGAAGTCACCACTGGCTACCGTGGCGTCCGCATCACCAACTTCACCACATCCTGGCGCAACGGCTTGGCCTTCTG
TGCCATCCTGCACCGATTCTACCCAGACAAGATTGACTATGCCTCGCTAGACCCACTCAACATCAAGCAGAACAACAAGCAGGCCTTCGA
TGGCTTCGCGGCTCTGGGCGTGTCGCGGCTGCTGGAGCCCGCGGACATGGTGCTACTGTCGGTGCCCGACAAGCTCATCGTCATGACGTA
CCTGTGCCAGATCCGCGCCTTCTGCACCGGGCAGGAGCTGCAGCTGGTACAACTGGAGGGCGGCGGCGGCGCCGGCACGTACCGCGTGGG
CAGCGCCCAGCCCAGCCCGCCCGACGACCTGGACGCCGGAGGCCTGGCGCAGCGGCTGCGCGGTCACGGGGCCGAGGGGCCCCAGGAGCC
CAAGGAGGCCGCAGACCGCGCAGACGGGGCGGCCCCGGGGGTGGCCTCCAGGAACGCGGTCGCGGGCCGCGCCTCCAAGGACGGCGGGGC
CGAGGCCCCCCGAGAGTCGCGACCCGCGGAGGTCCCGGCCGAGGGGCTGGTGAACGGGGCGGGGGCACCGGGCGGCGGCGGCGTGAGGCT
GCGACGGCCCTCGGTCAACGGGGAGCCCGGGTCGGTGCCCCCGCCCCGCGCGCACGGCTCCTTCTCCCACGTGCGCGACGCGGACCTGCT
CAAGAAGAGGCGCTCGCGGCTGCGGAACAGCAGCTCGTTCTCGATGGACGATCCGGACGCGGGAGCCATGGGAGCTGCGGCTGCAGAAGG
CCAGGCCCCTGACCCCAGCCCTGCCCCAGGCCCACCCACAGCTGCAGACTCTCAACAGCCCCCTGGTGGGAGTTCCCCCTCGGAGGAACC
ACCCCCAAGCCCAGGGGAGGAGGCTGGGCTGCAACGGTTCCAGGACACAAGTCAGTACGTGTGTGCAGAGCTGCAGGCCCTGGAACAGGA
GCAGAGGCAGATAGATGGGCGGGCGGCTGAGGTGGAGATGCAGCTGAGGAGCCTCATGGAGTCAGGTGCCAACAAGCTGCAGGAGGAGGT
GCTGATCCAGGAGTGGTTCACCCTGGTCAACAAGAAGAACGCTCTCATCCGGAGGCAGGACCAGCTGCAGCTGCTCATGGAGGAGCAGGA
CTTGGAGCGAAGGTTCGAGCTGCTGAGCCGCGAGCTGCGGGCCATGCTGGCCATCGAAGACTGGCAGAAAACGTCCGCTCAGCAGCACCG
AGAGCAGCTCCTACTGGAGGAGCTGGTGTCGCTGGTGAACCAGCGCGATGAGCTAGTCCGGGACCTGGACCACAAGGAGCGGATCGCCCT
GGAGGAGGACGAGCGCCTGGAGCGCGGCCTGGAACAGCGGCGCCGCAAGCTGAGCCGGCAGTTGAGCCGGCGGGAGCGCTGCGTGCTGAG
CTGAGGCCGCCGGCCCGGGTGGCCCATAACTTCTCGCGTCCCCGGCGTCCGCCGCCGCCCCGGGCCTGCGCTGCGGACGACCCGGCCGTC
CCGGAGGCCGCGCGCGTGTCCGCTAGGGGCCGCCGGCGCCCTTCCCCGTACAGGGCAGGGCGGATCCCCGACCCCACGGGCGGGGCGGCC
GCCGTATTTATTTGTCACCGAGGGTGTGTGCGCGCTCGCGGCGGGTGCGGGGTCCTCCCCGACGGCACGGCCGGGCCGGCGGCCTCGGGG

>In-frame_ENST00000437600_ENST00000309295_TCGA-37-4132-01A_CUX1_chr7_101459373_+_EHBP1L1_chr11_65351712_length(amino acids)=513AA_start in transcript=352_stop in transcript=1893
MAANVGSMFQYWKRFDLQQLQAPPALVSSSQSLLEWCQEVTTGYRGVRITNFTTSWRNGLAFCAILHRFYPDKIDYASLDPLNIKQNNKQ
AFDGFAALGVSRLLEPADMVLLSVPDKLIVMTYLCQIRAFCTGQELQLVQLEGGGGAGTYRVGSAQPSPPDDLDAGGLAQRLRGHGAEGP
QEPKEAADRADGAAPGVASRNAVAGRASKDGGAEAPRESRPAEVPAEGLVNGAGAPGGGGVRLRRPSVNGEPGSVPPPRAHGSFSHVRDA
DLLKKRRSRLRNSSSFSMDDPDAGAMGAAAAEGQAPDPSPAPGPPTAADSQQPPGGSSPSEEPPPSPGEEAGLQRFQDTSQYVCAELQAL
EQEQRQIDGRAAEVEMQLRSLMESGANKLQEEVLIQEWFTLVNKKNALIRRQDQLQLLMEEQDLERRFELLSRELRAMLAIEDWQKTSAQ

--------------------------------------------------------------
>In-frame_ENST00000292538_ENST00000309295_TCGA-37-4132-01A_CUX1_chr7_101459373_+_EHBP1L1_chr11_65351712_length(transcript)=1916nt_BP=89nt
CTCACTCCGTCTCAATATGTCTCAAGATGGCGGCCAATGTGGGATCGATGTTTCAATATTGGAAGCGCTTTGATTTACAGCAGCTGCAGG
CACCACCTGCCCTGGTCAGCTCCAGCCAGTCCCTGCTGGAGTGGTGCCAGGAAGTCACCACTGGCTACCGTGGCGTCCGCATCACCAACT
TCACCACATCCTGGCGCAACGGCTTGGCCTTCTGTGCCATCCTGCACCGATTCTACCCAGACAAGATTGACTATGCCTCGCTAGACCCAC
TCAACATCAAGCAGAACAACAAGCAGGCCTTCGATGGCTTCGCGGCTCTGGGCGTGTCGCGGCTGCTGGAGCCCGCGGACATGGTGCTAC
TGTCGGTGCCCGACAAGCTCATCGTCATGACGTACCTGTGCCAGATCCGCGCCTTCTGCACCGGGCAGGAGCTGCAGCTGGTACAACTGG
AGGGCGGCGGCGGCGCCGGCACGTACCGCGTGGGCAGCGCCCAGCCCAGCCCGCCCGACGACCTGGACGCCGGAGGCCTGGCGCAGCGGC
TGCGCGGTCACGGGGCCGAGGGGCCCCAGGAGCCCAAGGAGGCCGCAGACCGCGCAGACGGGGCGGCCCCGGGGGTGGCCTCCAGGAACG
CGGTCGCGGGCCGCGCCTCCAAGGACGGCGGGGCCGAGGCCCCCCGAGAGTCGCGACCCGCGGAGGTCCCGGCCGAGGGGCTGGTGAACG
GGGCGGGGGCACCGGGCGGCGGCGGCGTGAGGCTGCGACGGCCCTCGGTCAACGGGGAGCCCGGGTCGGTGCCCCCGCCCCGCGCGCACG
GCTCCTTCTCCCACGTGCGCGACGCGGACCTGCTCAAGAAGAGGCGCTCGCGGCTGCGGAACAGCAGCTCGTTCTCGATGGACGATCCGG
ACGCGGGAGCCATGGGAGCTGCGGCTGCAGAAGGCCAGGCCCCTGACCCCAGCCCTGCCCCAGGCCCACCCACAGCTGCAGACTCTCAAC
AGCCCCCTGGTGGGAGTTCCCCCTCGGAGGAACCACCCCCAAGCCCAGGGGAGGAGGCTGGGCTGCAACGGTTCCAGGACACAAGTCAGT
ACGTGTGTGCAGAGCTGCAGGCCCTGGAACAGGAGCAGAGGCAGATAGATGGGCGGGCGGCTGAGGTGGAGATGCAGCTGAGGAGCCTCA
TGGAGTCAGGTGCCAACAAGCTGCAGGAGGAGGTGCTGATCCAGGAGTGGTTCACCCTGGTCAACAAGAAGAACGCTCTCATCCGGAGGC
AGGACCAGCTGCAGCTGCTCATGGAGGAGCAGGACTTGGAGCGAAGGTTCGAGCTGCTGAGCCGCGAGCTGCGGGCCATGCTGGCCATCG
AAGACTGGCAGAAAACGTCCGCTCAGCAGCACCGAGAGCAGCTCCTACTGGAGGAGCTGGTGTCGCTGGTGAACCAGCGCGATGAGCTAG
TCCGGGACCTGGACCACAAGGAGCGGATCGCCCTGGAGGAGGACGAGCGCCTGGAGCGCGGCCTGGAACAGCGGCGCCGCAAGCTGAGCC
GGCAGTTGAGCCGGCGGGAGCGCTGCGTGCTGAGCTGAGGCCGCCGGCCCGGGTGGCCCATAACTTCTCGCGTCCCCGGCGTCCGCCGCC
GCCCCGGGCCTGCGCTGCGGACGACCCGGCCGTCCCGGAGGCCGCGCGCGTGTCCGCTAGGGGCCGCCGGCGCCCTTCCCCGTACAGGGC
AGGGCGGATCCCCGACCCCACGGGCGGGGCGGCCGCCGTATTTATTTGTCACCGAGGGTGTGTGCGCGCTCGCGGCGGGTGCGGGGTCCT
CCCCGACGGCACGGCCGGGCCGGCGGCCTCGGGGAGAGGGATGCCTGGGCACTACCGCCCCGCGCTGGCTTGCCCTCCTGTTCTCCAGAG

>In-frame_ENST00000292538_ENST00000309295_TCGA-37-4132-01A_CUX1_chr7_101459373_+_EHBP1L1_chr11_65351712_length(amino acids)=513AA_start in transcript=26_stop in transcript=1567
MAANVGSMFQYWKRFDLQQLQAPPALVSSSQSLLEWCQEVTTGYRGVRITNFTTSWRNGLAFCAILHRFYPDKIDYASLDPLNIKQNNKQ
AFDGFAALGVSRLLEPADMVLLSVPDKLIVMTYLCQIRAFCTGQELQLVQLEGGGGAGTYRVGSAQPSPPDDLDAGGLAQRLRGHGAEGP
QEPKEAADRADGAAPGVASRNAVAGRASKDGGAEAPRESRPAEVPAEGLVNGAGAPGGGGVRLRRPSVNGEPGSVPPPRAHGSFSHVRDA
DLLKKRRSRLRNSSSFSMDDPDAGAMGAAAAEGQAPDPSPAPGPPTAADSQQPPGGSSPSEEPPPSPGEEAGLQRFQDTSQYVCAELQAL
EQEQRQIDGRAAEVEMQLRSLMESGANKLQEEVLIQEWFTLVNKKNALIRRQDQLQLLMEEQDLERRFELLSRELRAMLAIEDWQKTSAQ

--------------------------------------------------------------
>In-frame_ENST00000393824_ENST00000309295_TCGA-37-4132-01A_CUX1_chr7_101459373_+_EHBP1L1_chr11_65351712_length(transcript)=1913nt_BP=86nt
ACTCCGTCTCAATATGTCTCAAGATGGCGGCCAATGTGGGATCGATGTTTCAATATTGGAAGCGCTTTGATTTACAGCAGCTGCAGGCAC
CACCTGCCCTGGTCAGCTCCAGCCAGTCCCTGCTGGAGTGGTGCCAGGAAGTCACCACTGGCTACCGTGGCGTCCGCATCACCAACTTCA
CCACATCCTGGCGCAACGGCTTGGCCTTCTGTGCCATCCTGCACCGATTCTACCCAGACAAGATTGACTATGCCTCGCTAGACCCACTCA
ACATCAAGCAGAACAACAAGCAGGCCTTCGATGGCTTCGCGGCTCTGGGCGTGTCGCGGCTGCTGGAGCCCGCGGACATGGTGCTACTGT
CGGTGCCCGACAAGCTCATCGTCATGACGTACCTGTGCCAGATCCGCGCCTTCTGCACCGGGCAGGAGCTGCAGCTGGTACAACTGGAGG
GCGGCGGCGGCGCCGGCACGTACCGCGTGGGCAGCGCCCAGCCCAGCCCGCCCGACGACCTGGACGCCGGAGGCCTGGCGCAGCGGCTGC
GCGGTCACGGGGCCGAGGGGCCCCAGGAGCCCAAGGAGGCCGCAGACCGCGCAGACGGGGCGGCCCCGGGGGTGGCCTCCAGGAACGCGG
TCGCGGGCCGCGCCTCCAAGGACGGCGGGGCCGAGGCCCCCCGAGAGTCGCGACCCGCGGAGGTCCCGGCCGAGGGGCTGGTGAACGGGG
CGGGGGCACCGGGCGGCGGCGGCGTGAGGCTGCGACGGCCCTCGGTCAACGGGGAGCCCGGGTCGGTGCCCCCGCCCCGCGCGCACGGCT
CCTTCTCCCACGTGCGCGACGCGGACCTGCTCAAGAAGAGGCGCTCGCGGCTGCGGAACAGCAGCTCGTTCTCGATGGACGATCCGGACG
CGGGAGCCATGGGAGCTGCGGCTGCAGAAGGCCAGGCCCCTGACCCCAGCCCTGCCCCAGGCCCACCCACAGCTGCAGACTCTCAACAGC
CCCCTGGTGGGAGTTCCCCCTCGGAGGAACCACCCCCAAGCCCAGGGGAGGAGGCTGGGCTGCAACGGTTCCAGGACACAAGTCAGTACG
TGTGTGCAGAGCTGCAGGCCCTGGAACAGGAGCAGAGGCAGATAGATGGGCGGGCGGCTGAGGTGGAGATGCAGCTGAGGAGCCTCATGG
AGTCAGGTGCCAACAAGCTGCAGGAGGAGGTGCTGATCCAGGAGTGGTTCACCCTGGTCAACAAGAAGAACGCTCTCATCCGGAGGCAGG
ACCAGCTGCAGCTGCTCATGGAGGAGCAGGACTTGGAGCGAAGGTTCGAGCTGCTGAGCCGCGAGCTGCGGGCCATGCTGGCCATCGAAG
ACTGGCAGAAAACGTCCGCTCAGCAGCACCGAGAGCAGCTCCTACTGGAGGAGCTGGTGTCGCTGGTGAACCAGCGCGATGAGCTAGTCC
GGGACCTGGACCACAAGGAGCGGATCGCCCTGGAGGAGGACGAGCGCCTGGAGCGCGGCCTGGAACAGCGGCGCCGCAAGCTGAGCCGGC
AGTTGAGCCGGCGGGAGCGCTGCGTGCTGAGCTGAGGCCGCCGGCCCGGGTGGCCCATAACTTCTCGCGTCCCCGGCGTCCGCCGCCGCC
CCGGGCCTGCGCTGCGGACGACCCGGCCGTCCCGGAGGCCGCGCGCGTGTCCGCTAGGGGCCGCCGGCGCCCTTCCCCGTACAGGGCAGG
GCGGATCCCCGACCCCACGGGCGGGGCGGCCGCCGTATTTATTTGTCACCGAGGGTGTGTGCGCGCTCGCGGCGGGTGCGGGGTCCTCCC
CGACGGCACGGCCGGGCCGGCGGCCTCGGGGAGAGGGATGCCTGGGCACTACCGCCCCGCGCTGGCTTGCCCTCCTGTTCTCCAGAGCAA

>In-frame_ENST00000393824_ENST00000309295_TCGA-37-4132-01A_CUX1_chr7_101459373_+_EHBP1L1_chr11_65351712_length(amino acids)=513AA_start in transcript=23_stop in transcript=1564
MAANVGSMFQYWKRFDLQQLQAPPALVSSSQSLLEWCQEVTTGYRGVRITNFTTSWRNGLAFCAILHRFYPDKIDYASLDPLNIKQNNKQ
AFDGFAALGVSRLLEPADMVLLSVPDKLIVMTYLCQIRAFCTGQELQLVQLEGGGGAGTYRVGSAQPSPPDDLDAGGLAQRLRGHGAEGP
QEPKEAADRADGAAPGVASRNAVAGRASKDGGAEAPRESRPAEVPAEGLVNGAGAPGGGGVRLRRPSVNGEPGSVPPPRAHGSFSHVRDA
DLLKKRRSRLRNSSSFSMDDPDAGAMGAAAAEGQAPDPSPAPGPPTAADSQQPPGGSSPSEEPPPSPGEEAGLQRFQDTSQYVCAELQAL
EQEQRQIDGRAAEVEMQLRSLMESGANKLQEEVLIQEWFTLVNKKNALIRRQDQLQLLMEEQDLERRFELLSRELRAMLAIEDWQKTSAQ

--------------------------------------------------------------
>In-frame_ENST00000547394_ENST00000309295_TCGA-37-4132-01A_CUX1_chr7_101459373_+_EHBP1L1_chr11_65351712_length(transcript)=1912nt_BP=85nt
CTCCGTCTCAATATGTCTCAAGATGGCGGCCAATGTGGGATCGATGTTTCAATATTGGAAGCGCTTTGATTTACAGCAGCTGCAGGCACC
ACCTGCCCTGGTCAGCTCCAGCCAGTCCCTGCTGGAGTGGTGCCAGGAAGTCACCACTGGCTACCGTGGCGTCCGCATCACCAACTTCAC
CACATCCTGGCGCAACGGCTTGGCCTTCTGTGCCATCCTGCACCGATTCTACCCAGACAAGATTGACTATGCCTCGCTAGACCCACTCAA
CATCAAGCAGAACAACAAGCAGGCCTTCGATGGCTTCGCGGCTCTGGGCGTGTCGCGGCTGCTGGAGCCCGCGGACATGGTGCTACTGTC
GGTGCCCGACAAGCTCATCGTCATGACGTACCTGTGCCAGATCCGCGCCTTCTGCACCGGGCAGGAGCTGCAGCTGGTACAACTGGAGGG
CGGCGGCGGCGCCGGCACGTACCGCGTGGGCAGCGCCCAGCCCAGCCCGCCCGACGACCTGGACGCCGGAGGCCTGGCGCAGCGGCTGCG
CGGTCACGGGGCCGAGGGGCCCCAGGAGCCCAAGGAGGCCGCAGACCGCGCAGACGGGGCGGCCCCGGGGGTGGCCTCCAGGAACGCGGT
CGCGGGCCGCGCCTCCAAGGACGGCGGGGCCGAGGCCCCCCGAGAGTCGCGACCCGCGGAGGTCCCGGCCGAGGGGCTGGTGAACGGGGC
GGGGGCACCGGGCGGCGGCGGCGTGAGGCTGCGACGGCCCTCGGTCAACGGGGAGCCCGGGTCGGTGCCCCCGCCCCGCGCGCACGGCTC
CTTCTCCCACGTGCGCGACGCGGACCTGCTCAAGAAGAGGCGCTCGCGGCTGCGGAACAGCAGCTCGTTCTCGATGGACGATCCGGACGC
GGGAGCCATGGGAGCTGCGGCTGCAGAAGGCCAGGCCCCTGACCCCAGCCCTGCCCCAGGCCCACCCACAGCTGCAGACTCTCAACAGCC
CCCTGGTGGGAGTTCCCCCTCGGAGGAACCACCCCCAAGCCCAGGGGAGGAGGCTGGGCTGCAACGGTTCCAGGACACAAGTCAGTACGT
GTGTGCAGAGCTGCAGGCCCTGGAACAGGAGCAGAGGCAGATAGATGGGCGGGCGGCTGAGGTGGAGATGCAGCTGAGGAGCCTCATGGA
GTCAGGTGCCAACAAGCTGCAGGAGGAGGTGCTGATCCAGGAGTGGTTCACCCTGGTCAACAAGAAGAACGCTCTCATCCGGAGGCAGGA
CCAGCTGCAGCTGCTCATGGAGGAGCAGGACTTGGAGCGAAGGTTCGAGCTGCTGAGCCGCGAGCTGCGGGCCATGCTGGCCATCGAAGA
CTGGCAGAAAACGTCCGCTCAGCAGCACCGAGAGCAGCTCCTACTGGAGGAGCTGGTGTCGCTGGTGAACCAGCGCGATGAGCTAGTCCG
GGACCTGGACCACAAGGAGCGGATCGCCCTGGAGGAGGACGAGCGCCTGGAGCGCGGCCTGGAACAGCGGCGCCGCAAGCTGAGCCGGCA
GTTGAGCCGGCGGGAGCGCTGCGTGCTGAGCTGAGGCCGCCGGCCCGGGTGGCCCATAACTTCTCGCGTCCCCGGCGTCCGCCGCCGCCC
CGGGCCTGCGCTGCGGACGACCCGGCCGTCCCGGAGGCCGCGCGCGTGTCCGCTAGGGGCCGCCGGCGCCCTTCCCCGTACAGGGCAGGG
CGGATCCCCGACCCCACGGGCGGGGCGGCCGCCGTATTTATTTGTCACCGAGGGTGTGTGCGCGCTCGCGGCGGGTGCGGGGTCCTCCCC
GACGGCACGGCCGGGCCGGCGGCCTCGGGGAGAGGGATGCCTGGGCACTACCGCCCCGCGCTGGCTTGCCCTCCTGTTCTCCAGAGCAAT

>In-frame_ENST00000547394_ENST00000309295_TCGA-37-4132-01A_CUX1_chr7_101459373_+_EHBP1L1_chr11_65351712_length(amino acids)=513AA_start in transcript=22_stop in transcript=1563
MAANVGSMFQYWKRFDLQQLQAPPALVSSSQSLLEWCQEVTTGYRGVRITNFTTSWRNGLAFCAILHRFYPDKIDYASLDPLNIKQNNKQ
AFDGFAALGVSRLLEPADMVLLSVPDKLIVMTYLCQIRAFCTGQELQLVQLEGGGGAGTYRVGSAQPSPPDDLDAGGLAQRLRGHGAEGP
QEPKEAADRADGAAPGVASRNAVAGRASKDGGAEAPRESRPAEVPAEGLVNGAGAPGGGGVRLRRPSVNGEPGSVPPPRAHGSFSHVRDA
DLLKKRRSRLRNSSSFSMDDPDAGAMGAAAAEGQAPDPSPAPGPPTAADSQQPPGGSSPSEEPPPSPGEEAGLQRFQDTSQYVCAELQAL
EQEQRQIDGRAAEVEMQLRSLMESGANKLQEEVLIQEWFTLVNKKNALIRRQDQLQLLMEEQDLERRFELLSRELRAMLAIEDWQKTSAQ

--------------------------------------------------------------
>In-frame_ENST00000360264_ENST00000309295_TCGA-37-4132-01A_CUX1_chr7_101459373_+_EHBP1L1_chr11_65351712_length(transcript)=1910nt_BP=83nt
CCGTCTCAATATGTCTCAAGATGGCGGCCAATGTGGGATCGATGTTTCAATATTGGAAGCGCTTTGATTTACAGCAGCTGCAGGCACCAC
CTGCCCTGGTCAGCTCCAGCCAGTCCCTGCTGGAGTGGTGCCAGGAAGTCACCACTGGCTACCGTGGCGTCCGCATCACCAACTTCACCA
CATCCTGGCGCAACGGCTTGGCCTTCTGTGCCATCCTGCACCGATTCTACCCAGACAAGATTGACTATGCCTCGCTAGACCCACTCAACA
TCAAGCAGAACAACAAGCAGGCCTTCGATGGCTTCGCGGCTCTGGGCGTGTCGCGGCTGCTGGAGCCCGCGGACATGGTGCTACTGTCGG
TGCCCGACAAGCTCATCGTCATGACGTACCTGTGCCAGATCCGCGCCTTCTGCACCGGGCAGGAGCTGCAGCTGGTACAACTGGAGGGCG
GCGGCGGCGCCGGCACGTACCGCGTGGGCAGCGCCCAGCCCAGCCCGCCCGACGACCTGGACGCCGGAGGCCTGGCGCAGCGGCTGCGCG
GTCACGGGGCCGAGGGGCCCCAGGAGCCCAAGGAGGCCGCAGACCGCGCAGACGGGGCGGCCCCGGGGGTGGCCTCCAGGAACGCGGTCG
CGGGCCGCGCCTCCAAGGACGGCGGGGCCGAGGCCCCCCGAGAGTCGCGACCCGCGGAGGTCCCGGCCGAGGGGCTGGTGAACGGGGCGG
GGGCACCGGGCGGCGGCGGCGTGAGGCTGCGACGGCCCTCGGTCAACGGGGAGCCCGGGTCGGTGCCCCCGCCCCGCGCGCACGGCTCCT
TCTCCCACGTGCGCGACGCGGACCTGCTCAAGAAGAGGCGCTCGCGGCTGCGGAACAGCAGCTCGTTCTCGATGGACGATCCGGACGCGG
GAGCCATGGGAGCTGCGGCTGCAGAAGGCCAGGCCCCTGACCCCAGCCCTGCCCCAGGCCCACCCACAGCTGCAGACTCTCAACAGCCCC
CTGGTGGGAGTTCCCCCTCGGAGGAACCACCCCCAAGCCCAGGGGAGGAGGCTGGGCTGCAACGGTTCCAGGACACAAGTCAGTACGTGT
GTGCAGAGCTGCAGGCCCTGGAACAGGAGCAGAGGCAGATAGATGGGCGGGCGGCTGAGGTGGAGATGCAGCTGAGGAGCCTCATGGAGT
CAGGTGCCAACAAGCTGCAGGAGGAGGTGCTGATCCAGGAGTGGTTCACCCTGGTCAACAAGAAGAACGCTCTCATCCGGAGGCAGGACC
AGCTGCAGCTGCTCATGGAGGAGCAGGACTTGGAGCGAAGGTTCGAGCTGCTGAGCCGCGAGCTGCGGGCCATGCTGGCCATCGAAGACT
GGCAGAAAACGTCCGCTCAGCAGCACCGAGAGCAGCTCCTACTGGAGGAGCTGGTGTCGCTGGTGAACCAGCGCGATGAGCTAGTCCGGG
ACCTGGACCACAAGGAGCGGATCGCCCTGGAGGAGGACGAGCGCCTGGAGCGCGGCCTGGAACAGCGGCGCCGCAAGCTGAGCCGGCAGT
TGAGCCGGCGGGAGCGCTGCGTGCTGAGCTGAGGCCGCCGGCCCGGGTGGCCCATAACTTCTCGCGTCCCCGGCGTCCGCCGCCGCCCCG
GGCCTGCGCTGCGGACGACCCGGCCGTCCCGGAGGCCGCGCGCGTGTCCGCTAGGGGCCGCCGGCGCCCTTCCCCGTACAGGGCAGGGCG
GATCCCCGACCCCACGGGCGGGGCGGCCGCCGTATTTATTTGTCACCGAGGGTGTGTGCGCGCTCGCGGCGGGTGCGGGGTCCTCCCCGA
CGGCACGGCCGGGCCGGCGGCCTCGGGGAGAGGGATGCCTGGGCACTACCGCCCCGCGCTGGCTTGCCCTCCTGTTCTCCAGAGCAATAA

>In-frame_ENST00000360264_ENST00000309295_TCGA-37-4132-01A_CUX1_chr7_101459373_+_EHBP1L1_chr11_65351712_length(amino acids)=513AA_start in transcript=20_stop in transcript=1561
MAANVGSMFQYWKRFDLQQLQAPPALVSSSQSLLEWCQEVTTGYRGVRITNFTTSWRNGLAFCAILHRFYPDKIDYASLDPLNIKQNNKQ
AFDGFAALGVSRLLEPADMVLLSVPDKLIVMTYLCQIRAFCTGQELQLVQLEGGGGAGTYRVGSAQPSPPDDLDAGGLAQRLRGHGAEGP
QEPKEAADRADGAAPGVASRNAVAGRASKDGGAEAPRESRPAEVPAEGLVNGAGAPGGGGVRLRRPSVNGEPGSVPPPRAHGSFSHVRDA
DLLKKRRSRLRNSSSFSMDDPDAGAMGAAAAEGQAPDPSPAPGPPTAADSQQPPGGSSPSEEPPPSPGEEAGLQRFQDTSQYVCAELQAL
EQEQRQIDGRAAEVEMQLRSLMESGANKLQEEVLIQEWFTLVNKKNALIRRQDQLQLLMEEQDLERRFELLSRELRAMLAIEDWQKTSAQ

--------------------------------------------------------------
>In-frame_ENST00000425244_ENST00000309295_TCGA-37-4132-01A_CUX1_chr7_101459373_+_EHBP1L1_chr11_65351712_length(transcript)=1900nt_BP=73nt
ATGTCTCAAGATGGCGGCCAATGTGGGATCGATGTTTCAATATTGGAAGCGCTTTGATTTACAGCAGCTGCAGGCACCACCTGCCCTGGT
CAGCTCCAGCCAGTCCCTGCTGGAGTGGTGCCAGGAAGTCACCACTGGCTACCGTGGCGTCCGCATCACCAACTTCACCACATCCTGGCG
CAACGGCTTGGCCTTCTGTGCCATCCTGCACCGATTCTACCCAGACAAGATTGACTATGCCTCGCTAGACCCACTCAACATCAAGCAGAA
CAACAAGCAGGCCTTCGATGGCTTCGCGGCTCTGGGCGTGTCGCGGCTGCTGGAGCCCGCGGACATGGTGCTACTGTCGGTGCCCGACAA
GCTCATCGTCATGACGTACCTGTGCCAGATCCGCGCCTTCTGCACCGGGCAGGAGCTGCAGCTGGTACAACTGGAGGGCGGCGGCGGCGC
CGGCACGTACCGCGTGGGCAGCGCCCAGCCCAGCCCGCCCGACGACCTGGACGCCGGAGGCCTGGCGCAGCGGCTGCGCGGTCACGGGGC
CGAGGGGCCCCAGGAGCCCAAGGAGGCCGCAGACCGCGCAGACGGGGCGGCCCCGGGGGTGGCCTCCAGGAACGCGGTCGCGGGCCGCGC
CTCCAAGGACGGCGGGGCCGAGGCCCCCCGAGAGTCGCGACCCGCGGAGGTCCCGGCCGAGGGGCTGGTGAACGGGGCGGGGGCACCGGG
CGGCGGCGGCGTGAGGCTGCGACGGCCCTCGGTCAACGGGGAGCCCGGGTCGGTGCCCCCGCCCCGCGCGCACGGCTCCTTCTCCCACGT
GCGCGACGCGGACCTGCTCAAGAAGAGGCGCTCGCGGCTGCGGAACAGCAGCTCGTTCTCGATGGACGATCCGGACGCGGGAGCCATGGG
AGCTGCGGCTGCAGAAGGCCAGGCCCCTGACCCCAGCCCTGCCCCAGGCCCACCCACAGCTGCAGACTCTCAACAGCCCCCTGGTGGGAG
TTCCCCCTCGGAGGAACCACCCCCAAGCCCAGGGGAGGAGGCTGGGCTGCAACGGTTCCAGGACACAAGTCAGTACGTGTGTGCAGAGCT
GCAGGCCCTGGAACAGGAGCAGAGGCAGATAGATGGGCGGGCGGCTGAGGTGGAGATGCAGCTGAGGAGCCTCATGGAGTCAGGTGCCAA
CAAGCTGCAGGAGGAGGTGCTGATCCAGGAGTGGTTCACCCTGGTCAACAAGAAGAACGCTCTCATCCGGAGGCAGGACCAGCTGCAGCT
GCTCATGGAGGAGCAGGACTTGGAGCGAAGGTTCGAGCTGCTGAGCCGCGAGCTGCGGGCCATGCTGGCCATCGAAGACTGGCAGAAAAC
GTCCGCTCAGCAGCACCGAGAGCAGCTCCTACTGGAGGAGCTGGTGTCGCTGGTGAACCAGCGCGATGAGCTAGTCCGGGACCTGGACCA
CAAGGAGCGGATCGCCCTGGAGGAGGACGAGCGCCTGGAGCGCGGCCTGGAACAGCGGCGCCGCAAGCTGAGCCGGCAGTTGAGCCGGCG
GGAGCGCTGCGTGCTGAGCTGAGGCCGCCGGCCCGGGTGGCCCATAACTTCTCGCGTCCCCGGCGTCCGCCGCCGCCCCGGGCCTGCGCT
GCGGACGACCCGGCCGTCCCGGAGGCCGCGCGCGTGTCCGCTAGGGGCCGCCGGCGCCCTTCCCCGTACAGGGCAGGGCGGATCCCCGAC
CCCACGGGCGGGGCGGCCGCCGTATTTATTTGTCACCGAGGGTGTGTGCGCGCTCGCGGCGGGTGCGGGGTCCTCCCCGACGGCACGGCC
GGGCCGGCGGCCTCGGGGAGAGGGATGCCTGGGCACTACCGCCCCGCGCTGGCTTGCCCTCCTGTTCTCCAGAGCAATAAAGTTGGACGA

>In-frame_ENST00000425244_ENST00000309295_TCGA-37-4132-01A_CUX1_chr7_101459373_+_EHBP1L1_chr11_65351712_length(amino acids)=513AA_start in transcript=10_stop in transcript=1551
MAANVGSMFQYWKRFDLQQLQAPPALVSSSQSLLEWCQEVTTGYRGVRITNFTTSWRNGLAFCAILHRFYPDKIDYASLDPLNIKQNNKQ
AFDGFAALGVSRLLEPADMVLLSVPDKLIVMTYLCQIRAFCTGQELQLVQLEGGGGAGTYRVGSAQPSPPDDLDAGGLAQRLRGHGAEGP
QEPKEAADRADGAAPGVASRNAVAGRASKDGGAEAPRESRPAEVPAEGLVNGAGAPGGGGVRLRRPSVNGEPGSVPPPRAHGSFSHVRDA
DLLKKRRSRLRNSSSFSMDDPDAGAMGAAAAEGQAPDPSPAPGPPTAADSQQPPGGSSPSEEPPPSPGEEAGLQRFQDTSQYVCAELQAL
EQEQRQIDGRAAEVEMQLRSLMESGANKLQEEVLIQEWFTLVNKKNALIRRQDQLQLLMEEQDLERRFELLSRELRAMLAIEDWQKTSAQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CUX1-EHBP1L1


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ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CUX1-EHBP1L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CUX1-EHBP1L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCUX1C0041696Unipolar Depression3PSYGENET
HgeneCUX1C1269683Major Depressive Disorder3PSYGENET
HgeneCUX1C0596263Carcinogenesis1CTD_human