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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:CXorf36-CHMP3 (FusionGDB2 ID:20858) |
Fusion Gene Summary for CXorf36-CHMP3 |
Fusion gene summary |
Fusion gene information | Fusion gene name: CXorf36-CHMP3 | Fusion gene ID: 20858 | Hgene | Tgene | Gene symbol | CXorf36 | CHMP3 | Gene ID | 79742 | 100526767 |
Gene name | divergent protein kinase domain 2B | RNF103-CHMP3 readthrough | |
Synonyms | 4930578C19Rik|CXorf36|DIA1R|EPQL1862|PRO3743|bA435K1.1 | CGI149|CHMP3|NEDF|RNF103-VPS24|VPS24|hVps24 | |
Cytomap | Xp11.3 | 2p11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | divergent protein kinase domain 2BUPF0672 protein CXorf36deleted in autism-1 related proteindeleted in autism-related protein 1hCG1981635 | RNF103-CHMP3 proteinCharged multivesicular body protein 3Chromatin-modifying protein 3Neuroendocrine differentiation factorRNF103-CHMP3 read-throughRNF103-VPS24 readthroughVacuolar protein sorting-associated protein 24 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | Q9Y3E7 | |
Ensembl transtripts involved in fusion gene | ENST00000398000, ENST00000477281, ENST00000377934, | ENST00000263856, ENST00000409727, ENST00000409225, ENST00000439940, ENST00000494623, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 3 X 3=45 |
# samples | 1 | 6 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/45*10)=0.415037499278844 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CXorf36 [Title/Abstract] AND CHMP3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CXorf36(45050996)-CHMP3(86769435), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene breakpoints across CXorf36 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across CHMP3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | Non-Cancer | ERR315476 | CXorf36 | chrX | 45050996 | - | CHMP3 | chr2 | 86769435 | - |
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Fusion Gene ORF analysis for CXorf36-CHMP3 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000398000 | ENST00000263856 | CXorf36 | chrX | 45050996 | - | CHMP3 | chr2 | 86769435 | - |
In-frame | ENST00000398000 | ENST00000409727 | CXorf36 | chrX | 45050996 | - | CHMP3 | chr2 | 86769435 | - |
5CDS-intron | ENST00000398000 | ENST00000409225 | CXorf36 | chrX | 45050996 | - | CHMP3 | chr2 | 86769435 | - |
5CDS-intron | ENST00000398000 | ENST00000439940 | CXorf36 | chrX | 45050996 | - | CHMP3 | chr2 | 86769435 | - |
5CDS-intron | ENST00000398000 | ENST00000494623 | CXorf36 | chrX | 45050996 | - | CHMP3 | chr2 | 86769435 | - |
intron-3CDS | ENST00000477281 | ENST00000263856 | CXorf36 | chrX | 45050996 | - | CHMP3 | chr2 | 86769435 | - |
intron-3CDS | ENST00000477281 | ENST00000409727 | CXorf36 | chrX | 45050996 | - | CHMP3 | chr2 | 86769435 | - |
intron-intron | ENST00000477281 | ENST00000409225 | CXorf36 | chrX | 45050996 | - | CHMP3 | chr2 | 86769435 | - |
intron-intron | ENST00000477281 | ENST00000439940 | CXorf36 | chrX | 45050996 | - | CHMP3 | chr2 | 86769435 | - |
intron-intron | ENST00000477281 | ENST00000494623 | CXorf36 | chrX | 45050996 | - | CHMP3 | chr2 | 86769435 | - |
In-frame | ENST00000377934 | ENST00000263856 | CXorf36 | chrX | 45050996 | - | CHMP3 | chr2 | 86769435 | - |
In-frame | ENST00000377934 | ENST00000409727 | CXorf36 | chrX | 45050996 | - | CHMP3 | chr2 | 86769435 | - |
5CDS-intron | ENST00000377934 | ENST00000409225 | CXorf36 | chrX | 45050996 | - | CHMP3 | chr2 | 86769435 | - |
5CDS-intron | ENST00000377934 | ENST00000439940 | CXorf36 | chrX | 45050996 | - | CHMP3 | chr2 | 86769435 | - |
5CDS-intron | ENST00000377934 | ENST00000494623 | CXorf36 | chrX | 45050996 | - | CHMP3 | chr2 | 86769435 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000398000 | CXorf36 | chrX | 45050996 | - | ENST00000263856 | CHMP3 | chr2 | 86769435 | - | 3570 | 573 | 15 | 1196 | 393 |
ENST00000398000 | CXorf36 | chrX | 45050996 | - | ENST00000409727 | CHMP3 | chr2 | 86769435 | - | 2353 | 573 | 15 | 1076 | 353 |
ENST00000377934 | CXorf36 | chrX | 45050996 | - | ENST00000263856 | CHMP3 | chr2 | 86769435 | - | 3570 | 573 | 15 | 1196 | 393 |
ENST00000377934 | CXorf36 | chrX | 45050996 | - | ENST00000409727 | CHMP3 | chr2 | 86769435 | - | 2353 | 573 | 15 | 1076 | 353 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000398000 | ENST00000263856 | CXorf36 | chrX | 45050996 | - | CHMP3 | chr2 | 86769435 | - | 0.000328104 | 0.99967194 |
ENST00000398000 | ENST00000409727 | CXorf36 | chrX | 45050996 | - | CHMP3 | chr2 | 86769435 | - | 0.001168344 | 0.9988317 |
ENST00000377934 | ENST00000263856 | CXorf36 | chrX | 45050996 | - | CHMP3 | chr2 | 86769435 | - | 0.000328104 | 0.99967194 |
ENST00000377934 | ENST00000409727 | CXorf36 | chrX | 45050996 | - | CHMP3 | chr2 | 86769435 | - | 0.001168344 | 0.9988317 |
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Fusion Genomic Features for CXorf36-CHMP3 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for CXorf36-CHMP3 |
Go to FGviewer for the breakpoints of chrX:45050996-chr2:86769435 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | CHMP3 |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress-mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells. {ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:15707591, ECO:0000269|PubMed:16740483, ECO:0000269|PubMed:17331679, ECO:0000269|PubMed:18076377}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | CHMP3 | chrX:45050996 | chr2:86769435 | ENST00000263856 | 0 | 6 | 141_222 | 15.0 | 223.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | CHMP3 | chrX:45050996 | chr2:86769435 | ENST00000263856 | 0 | 6 | 22_54 | 15.0 | 223.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | CHMP3 | chrX:45050996 | chr2:86769435 | ENST00000409225 | 0 | 5 | 141_222 | 0 | 157.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | CHMP3 | chrX:45050996 | chr2:86769435 | ENST00000409225 | 0 | 5 | 22_54 | 0 | 157.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | CHMP3 | chrX:45050996 | chr2:86769435 | ENST00000409727 | 0 | 6 | 141_222 | 15.0 | 183.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | CHMP3 | chrX:45050996 | chr2:86769435 | ENST00000409727 | 0 | 6 | 22_54 | 15.0 | 183.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | CHMP3 | chrX:45050996 | chr2:86769435 | ENST00000439940 | 2 | 8 | 141_222 | 44.0 | 252.0 | Coiled coil | Ontology_term=ECO:0000255 | |
Tgene | CHMP3 | chrX:45050996 | chr2:86769435 | ENST00000263856 | 0 | 6 | 201_211 | 15.0 | 223.0 | Motif | Note=MIT-interacting motif | |
Tgene | CHMP3 | chrX:45050996 | chr2:86769435 | ENST00000409225 | 0 | 5 | 201_211 | 0 | 157.0 | Motif | Note=MIT-interacting motif | |
Tgene | CHMP3 | chrX:45050996 | chr2:86769435 | ENST00000409727 | 0 | 6 | 201_211 | 15.0 | 183.0 | Motif | Note=MIT-interacting motif | |
Tgene | CHMP3 | chrX:45050996 | chr2:86769435 | ENST00000439940 | 2 | 8 | 201_211 | 44.0 | 252.0 | Motif | Note=MIT-interacting motif | |
Tgene | CHMP3 | chrX:45050996 | chr2:86769435 | ENST00000263856 | 0 | 6 | 59_64 | 15.0 | 223.0 | Region | Note=Important for autoinhibitory function | |
Tgene | CHMP3 | chrX:45050996 | chr2:86769435 | ENST00000409225 | 0 | 5 | 59_64 | 0 | 157.0 | Region | Note=Important for autoinhibitory function | |
Tgene | CHMP3 | chrX:45050996 | chr2:86769435 | ENST00000409727 | 0 | 6 | 59_64 | 15.0 | 183.0 | Region | Note=Important for autoinhibitory function | |
Tgene | CHMP3 | chrX:45050996 | chr2:86769435 | ENST00000439940 | 2 | 8 | 59_64 | 44.0 | 252.0 | Region | Note=Important for autoinhibitory function |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | CHMP3 | chrX:45050996 | chr2:86769435 | ENST00000439940 | 2 | 8 | 22_54 | 44.0 | 252.0 | Coiled coil | Ontology_term=ECO:0000255 |
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Fusion Gene Sequence for CXorf36-CHMP3 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000398000_ENST00000263856_ERR315476_CXorf36_chrX_45050996_-_CHMP3_chr2_86769435_length(transcript)=3570nt_BP=573nt CTCTTTGGCCAAGCCCTGCCTCTGTACAGCCTCGAGTGGACAGCCAGAGGCTGCAGCTGGAGCCCAGAGCCCAAGATGGAGCCCCAGCTG GGGCCTGAGGCTGCCGCCCTCCGCCCTGGCTGGCTGGCCCTGCTGCTGTGGGTCTCAGCCCTGAGCTGTTCTTTCTCCTTGCCAGCTTCT TCCCTTTCTTCTCTGGTGCCCCAAGTCAGAACCAGCTACAATTTTGGAAGGACTTTCCTCGGTCTTGATAAATGCAATGCCTGCATCGGG ACATCTATTTGCAAGAAGTTCTTTAAAGAAGAAATAAGATCTGACAACTGGCTGGCTTCCCACCTTGGACTGCCTCCCGATTCCTTGCTT TCTTATCCTGCAAATTACTCAGATGATTCCAAAATCTGGCGCCCTGTGGAGATCTTTAGACTGGTCAGCAAATATCAAAACGAGATCTCA GACAGGAGAATCTGTGCCTCTGCATCAGCCCCAAAGACCTGCAGCATTGAGCGTGTCCTGCGGAAAACAGAGAGGTTCCAGAAATGGCTG CAGGCCAAGCGCCTCACGCCGGACCTGGTGCAGGTCAATGAGTGGTCATTGAAGATAAGAAAGGAAATGAGAGTTGTTGACAGGCAAATA AGGGATATCCAAAGAGAAGAAGAAAAAGTGAAACGATCTGTGAAAGATGCTGCCAAGAAGGGCCAGAAGGATGTCTGCATAGTTCTGGCC AAGGAGATGATCAGGTCAAGGAAGGCTGTGAGCAAGCTGTATGCATCCAAAGCACACATGAACTCAGTGCTCATGGGGATGAAGAACCAG CTCGCGGTCTTGCGAGTGGCTGGTTCCCTGCAGAAGAGCACAGAAGTGATGAAGGCCATGCAAAGTCTTGTGAAGATTCCAGAGATTCAG GCCACCATGAGGGAGTTGTCCAAAGAAATGATGAAGGCTGGGATCATAGAGGAGATGTTAGAGGACACTTTTGAAAGCATGGACGATCAG GAAGAAATGGAGGAAGAAGCAGAAATGGAAATTGACAGAATTCTCTTTGAAATTACAGCAGGGGCCTTGGGCAAAGCACCCAGTAAAGTG ACTGATGCCCTTCCAGAGCCAGAACCTCCAGGAGCGATGGCTGCCTCAGAGGATGAGGAGGAGGAGGAAGAGGCTCTGGAGGCCATGCAG TCCCGGCTGGCCACACTCCGCAGCTAGGGGCTGCCTACCCCGCTGGGTGTGCACACACTCCTCTCAAGAGCTGCCATTTTATGTGTCTCT TGCACTACACCTCTGTTGTGAGGACTACCATTTTGGAGAAGGTTCTGTTTGTCTCTTTTCATTCTCTGCCCAGGTTTTGGGATCGCAAAG GGATTGTTCTTATAAAAGTGGCATAAATAAATGCATCATTTTTAGGAGTATAGACAGATATATCTTATTGTGGGGAGGGGAAAGAAATCC ATCTGCTCATGAAGCACTTCTGAAAATATAGGTGATTGCCTGAATGTCGAAGACTCTACTTTTGTCTATAAAACACTATATAAATGAATT TTAATAAATTTTTGCTTTAGCACTTGGCCCCATTGTAGATTGCCCTGTGCAGTAAACTTTCAAGGTGTCGGCTGCCCCAGATTGCTTCAT TTGCTGGGTGTGGAAAGAGTTGCTATGGCCAGGCATATGGGATTTGGAAGCTCAGCAGAAGTGACTTCTGCTCTGTGGTTGCTGCTCCCC GGCTTTCACAGACATGGTATGGCAGCCATTCTTTTATCTATTTAACCAAGAGGATGCTGGGGAATTGTGCTGCTTGTCCTGTTGGCTGGT GGCTGCATTATGTCCTGGGGTGTGCATGTGGGTCTATTTAGAGCTTCTGTCCCTTCCTTCCCATTGCAAGTTGCACCCAGATGAGACAGC TGTAGTACTAGGTCTCTTTCACCTCTCATTGCCTGTCCCTGCTTCGAGCTGGTTGTCTTGTGCGTGGGACATGGGCCTTCCTATCTGTGT TTTCTCAAAGTCAGGAGCTGACCAGGAGCACACTAAGGTGTGGTCATGCATCATAACCAACATTCACTCATCTGGGACATTCTTAAGATA CATTTATAAATCATTTCAGCAGTAGTACTTTGTATGTGTTGAGAGTTTACAGAGCTCTTTGACATACGCGATCTTAGTCTTTACAAATAA GGAAAACAGCTCAGTTTGGGAAGTATCAGAGATGGGATTCAAACCCAGATCCTCTGGTCCAAGTTGTATGTGCACTGAACTAATCAGGCA GGAAAAAAGCCCAGCCACTGTCTCACAGATTGTTTTTTGTATATTGTAGCAAAATCCTGAAACAATGGGGTCCTTCCAGTCTCATCATAC AAAATGGCAATCTTGGCTGGGTGCGGTGGTTCATGCCTATAATCCCAGTGCTTTACAAGGCTGAGGCAGGAGGCTCTCTTGAGAATAGGA GTTCAAGACCAGCCTGGGCAACATAGCAAGATCCTGTCTCTCCAAAAAAAAAAAAAAAAAAAAAAAAAAATTTCATTTTTGAGTCCAGAG GACCCTCCTATTACTCTTGATTTCATCTTCAGAGTGTAGTTAAAAAATTATTTTAAATAATTATTTTTTTAAATCAGTTGTAGGTTCACA GCAAAAGTGGACAAAAAGAAATTTCTCATATATCCCCTGCCCTCACACATGCATAGCCTCCCACCACTATCAGTATCCCACACCAGAGTG GTACATTTGTTACAATCAATAAACCTCCATTGACACATCATTATCACCCAAAGTCCATAGTTTACATGAAGATTCACTCTGGTGTTGTAC ATTGTATGGGCTTAGACAAATGTATGATGATATCTACAATTATAGAATCATACAGAATAGTTTCACTGCCCTAAAACTTCTCTATGCTTC ACCTGTTCATCCCTTTCTTCCCTAATCCCCTGGCAACCACTTTAAAAAAAAAATTAGGTTCAGGGGGTACATGTGCAGGTAAACTCGTGA CAAGGGGGTTTGTTATACAGATTATTTAGTGACCCAGGTACTAAGCCTAGTACCCAATAGTTACTTTTCTGGTCCTGTCCCTTTTCCCAC CCTCCACCCTCAGGTAGGCCCCAGTATGTTATTCCTTTGTGTCCATGTTATTTCACTCCCACTTGTGAGAACATGGAATATTTGGTTTCC TGTTCCTATGTTAGTTTGTTAAGGATAATGGCCTCCAGCCCCATCCATGTTCCTGCAAAGGACATGATCTTTCTTTGGCAACCACTTTTT ACTGTCGCCATAGTTCTTCCTTTTCTAGAATGTCATATTGGAATCATATAGTATGTAGCCTTTTCAGACTGGCTTCTTTCACTTAATAAT ATGCAATTAAGGTTCCTCCATGTCATTTCATGGCTTAATAGTGCATTTATTTTTAGCACTGAATAATACTCCATTGTCTAGATGAATAGT TTATCCATTCACCTATTGAAAGACTTCTTGGTGGTTTCCAAGTTTTGGCAATTATGAATAAAGCTGTTGTAAACATCTTTGTGCAGGTTT >In-frame_ENST00000398000_ENST00000263856_ERR315476_CXorf36_chrX_45050996_-_CHMP3_chr2_86769435_length(amino acids)=393AA_start in transcript=15_stop in transcript=1196 MPLYSLEWTARGCSWSPEPKMEPQLGPEAAALRPGWLALLLWVSALSCSFSLPASSLSSLVPQVRTSYNFGRTFLGLDKCNACIGTSICK KFFKEEIRSDNWLASHLGLPPDSLLSYPANYSDDSKIWRPVEIFRLVSKYQNEISDRRICASASAPKTCSIERVLRKTERFQKWLQAKRL TPDLVQVNEWSLKIRKEMRVVDRQIRDIQREEEKVKRSVKDAAKKGQKDVCIVLAKEMIRSRKAVSKLYASKAHMNSVLMGMKNQLAVLR VAGSLQKSTEVMKAMQSLVKIPEIQATMRELSKEMMKAGIIEEMLEDTFESMDDQEEMEEEAEMEIDRILFEITAGALGKAPSKVTDALP -------------------------------------------------------------- >In-frame_ENST00000398000_ENST00000409727_ERR315476_CXorf36_chrX_45050996_-_CHMP3_chr2_86769435_length(transcript)=2353nt_BP=573nt CTCTTTGGCCAAGCCCTGCCTCTGTACAGCCTCGAGTGGACAGCCAGAGGCTGCAGCTGGAGCCCAGAGCCCAAGATGGAGCCCCAGCTG GGGCCTGAGGCTGCCGCCCTCCGCCCTGGCTGGCTGGCCCTGCTGCTGTGGGTCTCAGCCCTGAGCTGTTCTTTCTCCTTGCCAGCTTCT TCCCTTTCTTCTCTGGTGCCCCAAGTCAGAACCAGCTACAATTTTGGAAGGACTTTCCTCGGTCTTGATAAATGCAATGCCTGCATCGGG ACATCTATTTGCAAGAAGTTCTTTAAAGAAGAAATAAGATCTGACAACTGGCTGGCTTCCCACCTTGGACTGCCTCCCGATTCCTTGCTT TCTTATCCTGCAAATTACTCAGATGATTCCAAAATCTGGCGCCCTGTGGAGATCTTTAGACTGGTCAGCAAATATCAAAACGAGATCTCA GACAGGAGAATCTGTGCCTCTGCATCAGCCCCAAAGACCTGCAGCATTGAGCGTGTCCTGCGGAAAACAGAGAGGTTCCAGAAATGGCTG CAGGCCAAGCGCCTCACGCCGGACCTGGTGCAGGTCAATGAGTGGTCATTGAAGATAAGAAAGGAAATGAGAGTTGTTGACAGGCAAATA AGGGATATCCAAAGAGAAGAAGAAAAAGTGAAACGATCTGTGAAAGATGCTGCCAAGAAGGGCCAGAAGGATGTCTGCATAGTTCTGGCC AAGGAGATGATCAGGTCAAGGAAGGCCATGCAAAGTCTTGTGAAGATTCCAGAGATTCAGGCCACCATGAGGGAGTTGTCCAAAGAAATG ATGAAGGCTGGGATCATAGAGGAGATGTTAGAGGACACTTTTGAAAGCATGGACGATCAGGAAGAAATGGAGGAAGAAGCAGAAATGGAA ATTGACAGAATTCTCTTTGAAATTACAGCAGGGGCCTTGGGCAAAGCACCCAGTAAAGTGACTGATGCCCTTCCAGAGCCAGAACCTCCA GGAGCGATGGCTGCCTCAGAGGATGAGGAGGAGGAGGAAGAGGCTCTGGAGGCCATGCAGTCCCGGCTGGCCACACTCCGCAGCTAGGGG CTGCCTACCCCGCTGGGTGTGCACACACTCCTCTCAAGAGCTGCCATTTTATGTGTCTCTTGCACTACACCTCTGTTGTGAGGACTACCA TTTTGGAGAAGGTTCTGTTTGTCTCTTTTCATTCTCTGCCCAGGTTTTGGGATCGCAAAGGGATTGTTCTTATAAAAGTGGCATAAATAA ATGCATCATTTTTAGGAGTATAGACAGATATATCTTATTGTGGGGAGGGGAAAGAAATCCATCTGCTCATGAAGCACTTCTGAAAATATA GGTGATTGCCTGAATGTCGAAGACTCTACTTTTGTCTATAAAACACTATATAAATGAATTTTAATAAATTTTTGCTTTAGCACTTGGCCC CATTGTAGATTGCCCTGTGCAGTAAACTTTCAAGGTGTCGGCTGCCCCAGATTGCTTCATTTGCTGGGTGTGGAAAGAGTTGCTATGGCC AGGCATATGGGATTTGGAAGCTCAGCAGAAGTGACTTCTGCTCTGTGGTTGCTGCTCCCCGGCTTTCACAGACATGGTATGGCAGCCATT CTTTTATCTATTTAACCAAGAGGATGCTGGGGAATTGTGCTGCTTGTCCTGTTGGCTGGTGGCTGCATTATGTCCTGGGGTGTGCATGTG GGTCTATTTAGAGCTTCTGTCCCTTCCTTCCCATTGCAAGTTGCACCCAGATGAGACAGCTGTAGTACTAGGTCTCTTTCACCTCTCATT GCCTGTCCCTGCTTCGAGCTGGTTGTCTTGTGCGTGGGACATGGGCCTTCCTATCTGTGTTTTCTCAAAGTCAGGAGCTGACCAGGAGCA CACTAAGGTGTGGTCATGCATCATAACCAACATTCACTCATCTGGGACATTCTTAAGATACATTTATAAATCATTTCAGCAGTAGTACTT TGTATGTGTTGAGAGTTTACAGAGCTCTTTGACATACGCGATCTTAGTCTTTACAAATAAGGAAAACAGCTCAGTTTGGGAAGTATCAGA GATGGGATTCAAACCCAGATCCTCTGGTCCAAGTTGTATGTGCACTGAACTAATCAGGCAGGAAAAAAGCCCAGCCACTGTCTCACAGAT TGTTTTTTGTATATTGTAGCAAAATCCTGAAACAATGGGGTCCTTCCAGTCTCATCATACAAAATGGCAATCTTGGCTGGGTGCGGTGGT TCATGCCTATAATCCCAGTGCTTTACAAGGCTGAGGCAGGAGGCTCTCTTGAGAATAGGAGTTCAAGACCAGCCTGGGCAACATAGCAAG >In-frame_ENST00000398000_ENST00000409727_ERR315476_CXorf36_chrX_45050996_-_CHMP3_chr2_86769435_length(amino acids)=353AA_start in transcript=15_stop in transcript=1076 MPLYSLEWTARGCSWSPEPKMEPQLGPEAAALRPGWLALLLWVSALSCSFSLPASSLSSLVPQVRTSYNFGRTFLGLDKCNACIGTSICK KFFKEEIRSDNWLASHLGLPPDSLLSYPANYSDDSKIWRPVEIFRLVSKYQNEISDRRICASASAPKTCSIERVLRKTERFQKWLQAKRL TPDLVQVNEWSLKIRKEMRVVDRQIRDIQREEEKVKRSVKDAAKKGQKDVCIVLAKEMIRSRKAMQSLVKIPEIQATMRELSKEMMKAGI -------------------------------------------------------------- >In-frame_ENST00000377934_ENST00000263856_ERR315476_CXorf36_chrX_45050996_-_CHMP3_chr2_86769435_length(transcript)=3570nt_BP=573nt CTCTTTGGCCAAGCCCTGCCTCTGTACAGCCTCGAGTGGACAGCCAGAGGCTGCAGCTGGAGCCCAGAGCCCAAGATGGAGCCCCAGCTG GGGCCTGAGGCTGCCGCCCTCCGCCCTGGCTGGCTGGCCCTGCTGCTGTGGGTCTCAGCCCTGAGCTGTTCTTTCTCCTTGCCAGCTTCT TCCCTTTCTTCTCTGGTGCCCCAAGTCAGAACCAGCTACAATTTTGGAAGGACTTTCCTCGGTCTTGATAAATGCAATGCCTGCATCGGG ACATCTATTTGCAAGAAGTTCTTTAAAGAAGAAATAAGATCTGACAACTGGCTGGCTTCCCACCTTGGACTGCCTCCCGATTCCTTGCTT TCTTATCCTGCAAATTACTCAGATGATTCCAAAATCTGGCGCCCTGTGGAGATCTTTAGACTGGTCAGCAAATATCAAAACGAGATCTCA GACAGGAGAATCTGTGCCTCTGCATCAGCCCCAAAGACCTGCAGCATTGAGCGTGTCCTGCGGAAAACAGAGAGGTTCCAGAAATGGCTG CAGGCCAAGCGCCTCACGCCGGACCTGGTGCAGGTCAATGAGTGGTCATTGAAGATAAGAAAGGAAATGAGAGTTGTTGACAGGCAAATA AGGGATATCCAAAGAGAAGAAGAAAAAGTGAAACGATCTGTGAAAGATGCTGCCAAGAAGGGCCAGAAGGATGTCTGCATAGTTCTGGCC AAGGAGATGATCAGGTCAAGGAAGGCTGTGAGCAAGCTGTATGCATCCAAAGCACACATGAACTCAGTGCTCATGGGGATGAAGAACCAG CTCGCGGTCTTGCGAGTGGCTGGTTCCCTGCAGAAGAGCACAGAAGTGATGAAGGCCATGCAAAGTCTTGTGAAGATTCCAGAGATTCAG GCCACCATGAGGGAGTTGTCCAAAGAAATGATGAAGGCTGGGATCATAGAGGAGATGTTAGAGGACACTTTTGAAAGCATGGACGATCAG GAAGAAATGGAGGAAGAAGCAGAAATGGAAATTGACAGAATTCTCTTTGAAATTACAGCAGGGGCCTTGGGCAAAGCACCCAGTAAAGTG ACTGATGCCCTTCCAGAGCCAGAACCTCCAGGAGCGATGGCTGCCTCAGAGGATGAGGAGGAGGAGGAAGAGGCTCTGGAGGCCATGCAG TCCCGGCTGGCCACACTCCGCAGCTAGGGGCTGCCTACCCCGCTGGGTGTGCACACACTCCTCTCAAGAGCTGCCATTTTATGTGTCTCT TGCACTACACCTCTGTTGTGAGGACTACCATTTTGGAGAAGGTTCTGTTTGTCTCTTTTCATTCTCTGCCCAGGTTTTGGGATCGCAAAG GGATTGTTCTTATAAAAGTGGCATAAATAAATGCATCATTTTTAGGAGTATAGACAGATATATCTTATTGTGGGGAGGGGAAAGAAATCC ATCTGCTCATGAAGCACTTCTGAAAATATAGGTGATTGCCTGAATGTCGAAGACTCTACTTTTGTCTATAAAACACTATATAAATGAATT TTAATAAATTTTTGCTTTAGCACTTGGCCCCATTGTAGATTGCCCTGTGCAGTAAACTTTCAAGGTGTCGGCTGCCCCAGATTGCTTCAT TTGCTGGGTGTGGAAAGAGTTGCTATGGCCAGGCATATGGGATTTGGAAGCTCAGCAGAAGTGACTTCTGCTCTGTGGTTGCTGCTCCCC GGCTTTCACAGACATGGTATGGCAGCCATTCTTTTATCTATTTAACCAAGAGGATGCTGGGGAATTGTGCTGCTTGTCCTGTTGGCTGGT GGCTGCATTATGTCCTGGGGTGTGCATGTGGGTCTATTTAGAGCTTCTGTCCCTTCCTTCCCATTGCAAGTTGCACCCAGATGAGACAGC TGTAGTACTAGGTCTCTTTCACCTCTCATTGCCTGTCCCTGCTTCGAGCTGGTTGTCTTGTGCGTGGGACATGGGCCTTCCTATCTGTGT TTTCTCAAAGTCAGGAGCTGACCAGGAGCACACTAAGGTGTGGTCATGCATCATAACCAACATTCACTCATCTGGGACATTCTTAAGATA CATTTATAAATCATTTCAGCAGTAGTACTTTGTATGTGTTGAGAGTTTACAGAGCTCTTTGACATACGCGATCTTAGTCTTTACAAATAA GGAAAACAGCTCAGTTTGGGAAGTATCAGAGATGGGATTCAAACCCAGATCCTCTGGTCCAAGTTGTATGTGCACTGAACTAATCAGGCA GGAAAAAAGCCCAGCCACTGTCTCACAGATTGTTTTTTGTATATTGTAGCAAAATCCTGAAACAATGGGGTCCTTCCAGTCTCATCATAC AAAATGGCAATCTTGGCTGGGTGCGGTGGTTCATGCCTATAATCCCAGTGCTTTACAAGGCTGAGGCAGGAGGCTCTCTTGAGAATAGGA GTTCAAGACCAGCCTGGGCAACATAGCAAGATCCTGTCTCTCCAAAAAAAAAAAAAAAAAAAAAAAAAAATTTCATTTTTGAGTCCAGAG GACCCTCCTATTACTCTTGATTTCATCTTCAGAGTGTAGTTAAAAAATTATTTTAAATAATTATTTTTTTAAATCAGTTGTAGGTTCACA GCAAAAGTGGACAAAAAGAAATTTCTCATATATCCCCTGCCCTCACACATGCATAGCCTCCCACCACTATCAGTATCCCACACCAGAGTG GTACATTTGTTACAATCAATAAACCTCCATTGACACATCATTATCACCCAAAGTCCATAGTTTACATGAAGATTCACTCTGGTGTTGTAC ATTGTATGGGCTTAGACAAATGTATGATGATATCTACAATTATAGAATCATACAGAATAGTTTCACTGCCCTAAAACTTCTCTATGCTTC ACCTGTTCATCCCTTTCTTCCCTAATCCCCTGGCAACCACTTTAAAAAAAAAATTAGGTTCAGGGGGTACATGTGCAGGTAAACTCGTGA CAAGGGGGTTTGTTATACAGATTATTTAGTGACCCAGGTACTAAGCCTAGTACCCAATAGTTACTTTTCTGGTCCTGTCCCTTTTCCCAC CCTCCACCCTCAGGTAGGCCCCAGTATGTTATTCCTTTGTGTCCATGTTATTTCACTCCCACTTGTGAGAACATGGAATATTTGGTTTCC TGTTCCTATGTTAGTTTGTTAAGGATAATGGCCTCCAGCCCCATCCATGTTCCTGCAAAGGACATGATCTTTCTTTGGCAACCACTTTTT ACTGTCGCCATAGTTCTTCCTTTTCTAGAATGTCATATTGGAATCATATAGTATGTAGCCTTTTCAGACTGGCTTCTTTCACTTAATAAT ATGCAATTAAGGTTCCTCCATGTCATTTCATGGCTTAATAGTGCATTTATTTTTAGCACTGAATAATACTCCATTGTCTAGATGAATAGT TTATCCATTCACCTATTGAAAGACTTCTTGGTGGTTTCCAAGTTTTGGCAATTATGAATAAAGCTGTTGTAAACATCTTTGTGCAGGTTT >In-frame_ENST00000377934_ENST00000263856_ERR315476_CXorf36_chrX_45050996_-_CHMP3_chr2_86769435_length(amino acids)=393AA_start in transcript=15_stop in transcript=1196 MPLYSLEWTARGCSWSPEPKMEPQLGPEAAALRPGWLALLLWVSALSCSFSLPASSLSSLVPQVRTSYNFGRTFLGLDKCNACIGTSICK KFFKEEIRSDNWLASHLGLPPDSLLSYPANYSDDSKIWRPVEIFRLVSKYQNEISDRRICASASAPKTCSIERVLRKTERFQKWLQAKRL TPDLVQVNEWSLKIRKEMRVVDRQIRDIQREEEKVKRSVKDAAKKGQKDVCIVLAKEMIRSRKAVSKLYASKAHMNSVLMGMKNQLAVLR VAGSLQKSTEVMKAMQSLVKIPEIQATMRELSKEMMKAGIIEEMLEDTFESMDDQEEMEEEAEMEIDRILFEITAGALGKAPSKVTDALP -------------------------------------------------------------- >In-frame_ENST00000377934_ENST00000409727_ERR315476_CXorf36_chrX_45050996_-_CHMP3_chr2_86769435_length(transcript)=2353nt_BP=573nt CTCTTTGGCCAAGCCCTGCCTCTGTACAGCCTCGAGTGGACAGCCAGAGGCTGCAGCTGGAGCCCAGAGCCCAAGATGGAGCCCCAGCTG GGGCCTGAGGCTGCCGCCCTCCGCCCTGGCTGGCTGGCCCTGCTGCTGTGGGTCTCAGCCCTGAGCTGTTCTTTCTCCTTGCCAGCTTCT TCCCTTTCTTCTCTGGTGCCCCAAGTCAGAACCAGCTACAATTTTGGAAGGACTTTCCTCGGTCTTGATAAATGCAATGCCTGCATCGGG ACATCTATTTGCAAGAAGTTCTTTAAAGAAGAAATAAGATCTGACAACTGGCTGGCTTCCCACCTTGGACTGCCTCCCGATTCCTTGCTT TCTTATCCTGCAAATTACTCAGATGATTCCAAAATCTGGCGCCCTGTGGAGATCTTTAGACTGGTCAGCAAATATCAAAACGAGATCTCA GACAGGAGAATCTGTGCCTCTGCATCAGCCCCAAAGACCTGCAGCATTGAGCGTGTCCTGCGGAAAACAGAGAGGTTCCAGAAATGGCTG CAGGCCAAGCGCCTCACGCCGGACCTGGTGCAGGTCAATGAGTGGTCATTGAAGATAAGAAAGGAAATGAGAGTTGTTGACAGGCAAATA AGGGATATCCAAAGAGAAGAAGAAAAAGTGAAACGATCTGTGAAAGATGCTGCCAAGAAGGGCCAGAAGGATGTCTGCATAGTTCTGGCC AAGGAGATGATCAGGTCAAGGAAGGCCATGCAAAGTCTTGTGAAGATTCCAGAGATTCAGGCCACCATGAGGGAGTTGTCCAAAGAAATG ATGAAGGCTGGGATCATAGAGGAGATGTTAGAGGACACTTTTGAAAGCATGGACGATCAGGAAGAAATGGAGGAAGAAGCAGAAATGGAA ATTGACAGAATTCTCTTTGAAATTACAGCAGGGGCCTTGGGCAAAGCACCCAGTAAAGTGACTGATGCCCTTCCAGAGCCAGAACCTCCA GGAGCGATGGCTGCCTCAGAGGATGAGGAGGAGGAGGAAGAGGCTCTGGAGGCCATGCAGTCCCGGCTGGCCACACTCCGCAGCTAGGGG CTGCCTACCCCGCTGGGTGTGCACACACTCCTCTCAAGAGCTGCCATTTTATGTGTCTCTTGCACTACACCTCTGTTGTGAGGACTACCA TTTTGGAGAAGGTTCTGTTTGTCTCTTTTCATTCTCTGCCCAGGTTTTGGGATCGCAAAGGGATTGTTCTTATAAAAGTGGCATAAATAA ATGCATCATTTTTAGGAGTATAGACAGATATATCTTATTGTGGGGAGGGGAAAGAAATCCATCTGCTCATGAAGCACTTCTGAAAATATA GGTGATTGCCTGAATGTCGAAGACTCTACTTTTGTCTATAAAACACTATATAAATGAATTTTAATAAATTTTTGCTTTAGCACTTGGCCC CATTGTAGATTGCCCTGTGCAGTAAACTTTCAAGGTGTCGGCTGCCCCAGATTGCTTCATTTGCTGGGTGTGGAAAGAGTTGCTATGGCC AGGCATATGGGATTTGGAAGCTCAGCAGAAGTGACTTCTGCTCTGTGGTTGCTGCTCCCCGGCTTTCACAGACATGGTATGGCAGCCATT CTTTTATCTATTTAACCAAGAGGATGCTGGGGAATTGTGCTGCTTGTCCTGTTGGCTGGTGGCTGCATTATGTCCTGGGGTGTGCATGTG GGTCTATTTAGAGCTTCTGTCCCTTCCTTCCCATTGCAAGTTGCACCCAGATGAGACAGCTGTAGTACTAGGTCTCTTTCACCTCTCATT GCCTGTCCCTGCTTCGAGCTGGTTGTCTTGTGCGTGGGACATGGGCCTTCCTATCTGTGTTTTCTCAAAGTCAGGAGCTGACCAGGAGCA CACTAAGGTGTGGTCATGCATCATAACCAACATTCACTCATCTGGGACATTCTTAAGATACATTTATAAATCATTTCAGCAGTAGTACTT TGTATGTGTTGAGAGTTTACAGAGCTCTTTGACATACGCGATCTTAGTCTTTACAAATAAGGAAAACAGCTCAGTTTGGGAAGTATCAGA GATGGGATTCAAACCCAGATCCTCTGGTCCAAGTTGTATGTGCACTGAACTAATCAGGCAGGAAAAAAGCCCAGCCACTGTCTCACAGAT TGTTTTTTGTATATTGTAGCAAAATCCTGAAACAATGGGGTCCTTCCAGTCTCATCATACAAAATGGCAATCTTGGCTGGGTGCGGTGGT TCATGCCTATAATCCCAGTGCTTTACAAGGCTGAGGCAGGAGGCTCTCTTGAGAATAGGAGTTCAAGACCAGCCTGGGCAACATAGCAAG >In-frame_ENST00000377934_ENST00000409727_ERR315476_CXorf36_chrX_45050996_-_CHMP3_chr2_86769435_length(amino acids)=353AA_start in transcript=15_stop in transcript=1076 MPLYSLEWTARGCSWSPEPKMEPQLGPEAAALRPGWLALLLWVSALSCSFSLPASSLSSLVPQVRTSYNFGRTFLGLDKCNACIGTSICK KFFKEEIRSDNWLASHLGLPPDSLLSYPANYSDDSKIWRPVEIFRLVSKYQNEISDRRICASASAPKTCSIERVLRKTERFQKWLQAKRL TPDLVQVNEWSLKIRKEMRVVDRQIRDIQREEEKVKRSVKDAAKKGQKDVCIVLAKEMIRSRKAMQSLVKIPEIQATMRELSKEMMKAGI -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for CXorf36-CHMP3 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
Tgene | CHMP3 | chrX:45050996 | chr2:86769435 | ENST00000263856 | 0 | 6 | 203_207 | 15.0 | 223.0 | STAMBP | |
Tgene | CHMP3 | chrX:45050996 | chr2:86769435 | ENST00000409225 | 0 | 5 | 203_207 | 0 | 157.0 | STAMBP | |
Tgene | CHMP3 | chrX:45050996 | chr2:86769435 | ENST00000409727 | 0 | 6 | 203_207 | 15.0 | 183.0 | STAMBP | |
Tgene | CHMP3 | chrX:45050996 | chr2:86769435 | ENST00000439940 | 2 | 8 | 203_207 | 44.0 | 252.0 | STAMBP | |
Tgene | CHMP3 | chrX:45050996 | chr2:86769435 | ENST00000263856 | 0 | 6 | 151_222 | 15.0 | 223.0 | VPS4A | |
Tgene | CHMP3 | chrX:45050996 | chr2:86769435 | ENST00000409225 | 0 | 5 | 151_222 | 0 | 157.0 | VPS4A | |
Tgene | CHMP3 | chrX:45050996 | chr2:86769435 | ENST00000409727 | 0 | 6 | 151_222 | 15.0 | 183.0 | VPS4A | |
Tgene | CHMP3 | chrX:45050996 | chr2:86769435 | ENST00000439940 | 2 | 8 | 151_222 | 44.0 | 252.0 | VPS4A |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CXorf36-CHMP3 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CXorf36-CHMP3 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |