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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CXorf40A-SPP1 (FusionGDB2 ID:20860)

Fusion Gene Summary for CXorf40A-SPP1

check button Fusion gene summary
Fusion gene informationFusion gene name: CXorf40A-SPP1
Fusion gene ID: 20860
HgeneTgene
Gene symbol

CXorf40A

SPP1

Gene ID

91966

30827

Gene nameendothelium and lymphocyte associated ASCH domain 1CXXC finger protein 1
SynonymsCXorf40|CXorf40A2410002I16Rik|5830420C16Rik|CFP1|CGBP|HsT2645|PCCX1|PHF18|SPP1|ZCGPC1|hCGBP
Cytomap

Xq28

18q21.1

Type of geneprotein-codingprotein-coding
Descriptionprotein CXorf40Aendothelial-overexpressed lipopolysaccharide-associated factor 1CXXC-type zinc finger protein 1CXXC finger 1 (PHD domain)CpG binding proteinDNA-binding protein with PHD finger and CXXC domainPHD finger and CXXC domain-containing protein 1cpG-binding proteinzinc finger, CpG binding-type containing 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000450602, ENST00000441248, 
ENST00000393985, ENST00000423421, 
ENST00000423540, ENST00000434353, 
ENST00000514208, ENST00000448332, 
ENST00000428236, ENST00000422892, 
ENST00000359293, 		ENST00000237623, 
ENST00000395080, ENST00000360804, 
ENST00000509659, 
Fusion gene scores* DoF score1 X 1 X 1=19 X 10 X 3=270
# samples 111
** MAII scorelog2(1/1*10)=3.32192809488736log2(11/270*10)=-1.29545588352617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CXorf40A [Title/Abstract] AND SPP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCXorf40A(148628368)-SPP1(88903643), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCXorf40A

GO:0010468

regulation of gene expression

24916366

HgeneCXorf40A

GO:0032675

regulation of interleukin-6 production

24916366

TgeneSPP1

GO:0006355

regulation of transcription, DNA-templated

10688657

TgeneSPP1

GO:0045893

positive regulation of transcription, DNA-templated

10688657

TgeneSPP1

GO:0051568

histone H3-K4 methylation

17355966


check buttonFusion gene breakpoints across CXorf40A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SPP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAX184495CXorf40AchrX

148628368

+SPP1chr4

88903643

+
ChiTaRS5.0N/AAX186158CXorf40AchrX

148628368

+SPP1chr4

88903643

+
ChiTaRS5.0N/AAX187360CXorf40AchrX

148628368

+SPP1chr4

88903643

+
ChiTaRS5.0N/AAX188168CXorf40AchrX

148628368

+SPP1chr4

88903643

+


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Fusion Gene ORF analysis for CXorf40A-SPP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000450602ENST00000237623CXorf40AchrX

148628368

+SPP1chr4

88903643

+
Frame-shiftENST00000450602ENST00000395080CXorf40AchrX

148628368

+SPP1chr4

88903643

+
Frame-shiftENST00000450602ENST00000360804CXorf40AchrX

148628368

+SPP1chr4

88903643

+
5CDS-3UTRENST00000450602ENST00000509659CXorf40AchrX

148628368

+SPP1chr4

88903643

+
In-frameENST00000441248ENST00000237623CXorf40AchrX

148628368

+SPP1chr4

88903643

+
Frame-shiftENST00000441248ENST00000395080CXorf40AchrX

148628368

+SPP1chr4

88903643

+
Frame-shiftENST00000441248ENST00000360804CXorf40AchrX

148628368

+SPP1chr4

88903643

+
5CDS-3UTRENST00000441248ENST00000509659CXorf40AchrX

148628368

+SPP1chr4

88903643

+
Frame-shiftENST00000393985ENST00000237623CXorf40AchrX

148628368

+SPP1chr4

88903643

+
Frame-shiftENST00000393985ENST00000395080CXorf40AchrX

148628368

+SPP1chr4

88903643

+
In-frameENST00000393985ENST00000360804CXorf40AchrX

148628368

+SPP1chr4

88903643

+
5CDS-3UTRENST00000393985ENST00000509659CXorf40AchrX

148628368

+SPP1chr4

88903643

+
In-frameENST00000423421ENST00000237623CXorf40AchrX

148628368

+SPP1chr4

88903643

+
Frame-shiftENST00000423421ENST00000395080CXorf40AchrX

148628368

+SPP1chr4

88903643

+
Frame-shiftENST00000423421ENST00000360804CXorf40AchrX

148628368

+SPP1chr4

88903643

+
5CDS-3UTRENST00000423421ENST00000509659CXorf40AchrX

148628368

+SPP1chr4

88903643

+
Frame-shiftENST00000423540ENST00000237623CXorf40AchrX

148628368

+SPP1chr4

88903643

+
Frame-shiftENST00000423540ENST00000395080CXorf40AchrX

148628368

+SPP1chr4

88903643

+
In-frameENST00000423540ENST00000360804CXorf40AchrX

148628368

+SPP1chr4

88903643

+
5CDS-3UTRENST00000423540ENST00000509659CXorf40AchrX

148628368

+SPP1chr4

88903643

+
Frame-shiftENST00000434353ENST00000237623CXorf40AchrX

148628368

+SPP1chr4

88903643

+
Frame-shiftENST00000434353ENST00000395080CXorf40AchrX

148628368

+SPP1chr4

88903643

+
In-frameENST00000434353ENST00000360804CXorf40AchrX

148628368

+SPP1chr4

88903643

+
5CDS-3UTRENST00000434353ENST00000509659CXorf40AchrX

148628368

+SPP1chr4

88903643

+
Frame-shiftENST00000514208ENST00000237623CXorf40AchrX

148628368

+SPP1chr4

88903643

+
Frame-shiftENST00000514208ENST00000395080CXorf40AchrX

148628368

+SPP1chr4

88903643

+
In-frameENST00000514208ENST00000360804CXorf40AchrX

148628368

+SPP1chr4

88903643

+
5CDS-3UTRENST00000514208ENST00000509659CXorf40AchrX

148628368

+SPP1chr4

88903643

+
intron-3CDSENST00000448332ENST00000237623CXorf40AchrX

148628368

+SPP1chr4

88903643

+
intron-3CDSENST00000448332ENST00000395080CXorf40AchrX

148628368

+SPP1chr4

88903643

+
intron-3CDSENST00000448332ENST00000360804CXorf40AchrX

148628368

+SPP1chr4

88903643

+
intron-3UTRENST00000448332ENST00000509659CXorf40AchrX

148628368

+SPP1chr4

88903643

+
In-frameENST00000428236ENST00000237623CXorf40AchrX

148628368

+SPP1chr4

88903643

+
Frame-shiftENST00000428236ENST00000395080CXorf40AchrX

148628368

+SPP1chr4

88903643

+
Frame-shiftENST00000428236ENST00000360804CXorf40AchrX

148628368

+SPP1chr4

88903643

+
5CDS-3UTRENST00000428236ENST00000509659CXorf40AchrX

148628368

+SPP1chr4

88903643

+
Frame-shiftENST00000422892ENST00000237623CXorf40AchrX

148628368

+SPP1chr4

88903643

+
Frame-shiftENST00000422892ENST00000395080CXorf40AchrX

148628368

+SPP1chr4

88903643

+
In-frameENST00000422892ENST00000360804CXorf40AchrX

148628368

+SPP1chr4

88903643

+
5CDS-3UTRENST00000422892ENST00000509659CXorf40AchrX

148628368

+SPP1chr4

88903643

+
In-frameENST00000359293ENST00000237623CXorf40AchrX

148628368

+SPP1chr4

88903643

+
Frame-shiftENST00000359293ENST00000395080CXorf40AchrX

148628368

+SPP1chr4

88903643

+
Frame-shiftENST00000359293ENST00000360804CXorf40AchrX

148628368

+SPP1chr4

88903643

+
5CDS-3UTRENST00000359293ENST00000509659CXorf40AchrX

148628368

+SPP1chr4

88903643

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000450602CXorf40AchrX148628368+ENST00000237623SPP1chr488903643+2039112016702228
ENST00000441248CXorf40AchrX148628368+ENST00000237623SPP1chr488903643+3246232712351909224
ENST00000393985CXorf40AchrX148628368+ENST00000360804SPP1chr488903643+17001064331921196
ENST00000423421CXorf40AchrX148628368+ENST00000237623SPP1chr488903643+22381319302901199
ENST00000423540CXorf40AchrX148628368+ENST00000360804SPP1chr488903643+17601124343861172
ENST00000434353CXorf40AchrX148628368+ENST00000360804SPP1chr488903643+15519155671319250
ENST00000514208CXorf40AchrX148628368+ENST00000360804SPP1chr488903643+12976613131065250
ENST00000428236CXorf40AchrX148628368+ENST00000237623SPP1chr488903643+172280333455140
ENST00000422892CXorf40AchrX148628368+ENST00000360804SPP1chr488903643+15118755271279250
ENST00000359293CXorf40AchrX148628368+ENST00000237623SPP1chr488903643+180989072545157

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000450602ENST00000237623CXorf40AchrX148628368+SPP1chr488903643+0.161057220.83894277
ENST00000441248ENST00000237623CXorf40AchrX148628368+SPP1chr488903643+0.50646540.49353462
ENST00000393985ENST00000360804CXorf40AchrX148628368+SPP1chr488903643+0.280655260.7193447
ENST00000423421ENST00000237623CXorf40AchrX148628368+SPP1chr488903643+0.135901480.86409855
ENST00000423540ENST00000360804CXorf40AchrX148628368+SPP1chr488903643+0.1007344350.8992655
ENST00000434353ENST00000360804CXorf40AchrX148628368+SPP1chr488903643+0.003646860.99635315
ENST00000514208ENST00000360804CXorf40AchrX148628368+SPP1chr488903643+0.0034824080.99651754
ENST00000428236ENST00000237623CXorf40AchrX148628368+SPP1chr488903643+0.0099803520.9900197
ENST00000422892ENST00000360804CXorf40AchrX148628368+SPP1chr488903643+0.0025725790.9974274
ENST00000359293ENST00000237623CXorf40AchrX148628368+SPP1chr488903643+0.116905690.8830943

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Fusion Genomic Features for CXorf40A-SPP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CXorf40A-SPP1


check button Go to

FGviewer for the breakpoints of chrX:148628368-chr4:88903643

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSPP1chrX:148628368chr4:88903643ENST0000036080446159_161153.0288.0MotifNote=Cell attachment site

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCXorf40AchrX:148628368chr4:88903643ENST00000359293+126_920159.0DomainASCH
HgeneCXorf40AchrX:148628368chr4:88903643ENST00000393985+156_920159.0DomainASCH
HgeneCXorf40AchrX:148628368chr4:88903643ENST00000422892+156_920147.0DomainASCH
HgeneCXorf40AchrX:148628368chr4:88903643ENST00000423421+156_920159.0DomainASCH
HgeneCXorf40AchrX:148628368chr4:88903643ENST00000423540+156_920159.0DomainASCH
HgeneCXorf40AchrX:148628368chr4:88903643ENST00000434353+166_920147.0DomainASCH
HgeneCXorf40AchrX:148628368chr4:88903643ENST00000441248+146_920159.0DomainASCH
HgeneCXorf40AchrX:148628368chr4:88903643ENST00000450602+156_920159.0DomainASCH
HgeneCXorf40AchrX:148628368chr4:88903643ENST00000514208+166_920147.0DomainASCH
TgeneSPP1chrX:148628368chr4:88903643ENST0000023762346159_161166.0301.0MotifNote=Cell attachment site
TgeneSPP1chrX:148628368chr4:88903643ENST0000039508057159_161180.0315.0MotifNote=Cell attachment site


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Fusion Gene Sequence for CXorf40A-SPP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000450602_ENST00000237623_AX184495_CXorf40A_chrX_148628368_+_SPP1_chr4_88903643_length(transcript)=2039nt_BP=1120nt
TGCTGGTATAGCAGCTCTGGGCCCAAAACTCCTGCCTGGTGTCCTCGTCCCACCCTTCCACTTACTCTTCCTCCCTCCCGTTCCTTTTCC
TCCTTCCGGTTCTTCGTCGAGGCTGCCGGTCTCGAGGTCCCCTGGCCTTGGCCTGGTTGGCTGGCGCGCATCAGGGCCAGGTAAAGAAGC
TAAGTGGAAGAGTGTTTCCTCCTCTGGCCGTAAAGCAGCTGTCCCCGCCCTACTCCGGACCGCCCCAAAGACTCCATGGGATGGACCTGA
GTCAGCCGAATCCCAGCCCCTTCCCTTGGGCCTGCTGTGGTGCTGGACATCAGTGACAGACGGAAGCAGGAGACCATCAAGGCTACGGGA
GGCCCGGGGCGCTTGCGAAGATGAAGTTTGGCTGCCTCTCCTTCCGGCAGCCTTATGCTGGCTTTGTCTTAAATGGAATCAAGACTGTGG
AGACGCGCTGGCGTCCCCTGCTGAGCAGCCAGCGGAACTGTACCATCGCCGTCCACATTGCTCACAGGGACTGGGAAGGCGATGCCTGGC
GGGAGCTGCTGGTGGAGAGACTCGGGATGACTCCTGCTCAGATTCAGACCTTGCTCAGGAAAGGGGAAAAGTTTGGTCGAGGAGTGATAG
CGGTGACCAACCTGAAGCAGAAGTACCTGACTGTGATTTCAAACCCCAGGTGGTTACTGGAGCCCATACCTAGGAAAGGAGGCAAGGATG
TATTCCAGGTAGACATCCCAGAGCACCTGATCCCATTGGGGCATGAAGTGTGACAAGTGTGGGCTCCTGAAAGGAATGTTCCAGAGAAAC
CAGCTAAATCATGACACCTTCAATTTGCCATCATGACGCAGACCTGTATACATTAGGTTAAATCTGAATTTCCACTGCTTTGGAGAGTCC
CACCCACTAAGCACTGTGCATGTAAACAGGTTCCTTTGCTCAGATGAAGGAAGTAGGGGGTGGGGCTTTCCTTGTGTGATGCCTCCTTAG
GCACACAGGCAATGTCTCAAGTACTTTGACCTTAGGGTAGAAGGCAAAGCTGCCAGTAAATGTCTCAGCATTGCTGCTAATTTTGGTCCT
GCTAGTTTCTGGATTGTACAAATAAATGTGTTGTAGATGATACCCTGATGCTACAGACGAGGACATCACCTCACACATGGAAAGCGAGGA
GTTGAATGGTGCATACAAGGCCATCCCCGTTGCCCAGGACCTGAACGCGCCTTCTGATTGGGACAGCCGTGGGAAGGACAGTTATGAAAC
GAGTCAGCTGGATGACCAGAGTGCTGAAACCCACAGCCACAAGCAGTCCAGATTATATAAGCGGAAAGCCAATGATGAGAGCAATGAGCA
TTCCGATGTGATTGATAGTCAGGAACTTTCCAAAGTCAGCCGTGAATTCCACAGCCATGAATTTCACAGCCATGAAGATATGCTGGTTGT
AGACCCCAAAAGTAAGGAAGAAGATAAACACCTGAAATTTCGTATTTCTCATGAATTAGATAGTGCATCTTCTGAGGTCAATTAAAAGGA
GAAAAAATACAATTTCTCACTTTGCATTTAGTCAAAAGAAAAAATGCTTTATAGCAAAATGAAAGAGAACATGAAATGCTTCTTTCTCAG
TTTATTGGTTGAATGTGTATCTATTTGAGTCTGGAAATAACTAATGTGTTTGATAATTAGTTTAGTTTGTGGCTTCATGGAAACTCCCTG
TAAACTAAAAGCTTCAGGGTTATGTCTATGTTCATTCTATAGAAGAAATGCAAACTATCACTGTATTTTAATATTTGTTATTCTCTCATG
AATAGAAATTTATGTAGAAGCAAACAAAATACTTTTACCCACTTAAAAAGAGAATATAACATTTTATGTCACTATAATCTTTTGTTTTTT
AAGTTAGTGTATATTTTGTTGTGATTATCTTTTTGTGGTGTGAATAAATCTTTTATCTTGAATGTAATAAGAATTTGGTGGTGTCAATTG

>In-frame_ENST00000450602_ENST00000237623_AX184495_CXorf40A_chrX_148628368_+_SPP1_chr4_88903643_length(amino acids)=228AA_start in transcript=16_stop in transcript=702
MGPKLLPGVLVPPFHLLFLPPVPFPPSGSSSRLPVSRSPGLGLVGWRASGPGKEAKWKSVSSSGRKAAVPALLRTAPKTPWDGPESAESQ
PLPLGLLWCWTSVTDGSRRPSRLREARGACEDEVWLPLLPAALCWLCLKWNQDCGDALASPAEQPAELYHRRPHCSQGLGRRCLAGAAGG

--------------------------------------------------------------
>In-frame_ENST00000441248_ENST00000237623_AX184495_CXorf40A_chrX_148628368_+_SPP1_chr4_88903643_length(transcript)=3246nt_BP=2327nt
AGCTCTGGGCCCAAAACTCCTGCCTGGTGTCCTCGTCCCACCCTTCCACTTACTCTTCCTCCCTCCCGTTCCTTTTCCTCCTTCCGGTTC
TTCGTCGAGGCTGCCGGTCTCGAGGTCCCCTGGCCTTGGCCTGGTTGGCTGGCGCGCATCAGGGCCAGGTAAAGAGAATAGCGTCTCCTA
GCAGCCAGGGCGTGCGTAGGTGCGTGATGTCCTCAGTGCGTGTCTTCGAGAATGCGAGATTCATAATGTTTGCTGTCTATATGCATGGCT
GAGTACGTGCCTCCCGCGTACGTGCGTGGTGTGCATACATGCGTGATTGCGAGCCCACGTACGTTCTTCGTGAAAGGGATGACGGGAGCT
GTATGAAAGCGGAAGAGTTATAGACCGCTAACACCTGTCACTGGCCACTGGTTTCCCGGAGTTAGCGGCAACGACCTTGCAGCCTGGACA
CTAGCCAGGCGCTCCCTCTTCTCACAGCGGCCCACGTCTCCTTGCTTGGGAGCCCATCGTCCTGGCTCCGGTGGCCTCGCTGGGTCTCGG
GGAGGCAGAGGACTGTTCTTTCCTGTGGCGAAAAGCCGGAGTCGGCCCTAGACACCCACGACTCGCAGGGTCCATGGTTCCGGAGGCCGT
GAGACCTGCCGGGGCTGACAGGTGCCAGGGCCCATGCTGCGGGAGCCTGTGTGCTCAGCCTTCTTGCGGACGGTACCTGAGGGCTGGGGT
TTCCCTGGATGTGGGGCTGGGAACTCGTGCGGGGCGCGACCGAGGCGCCTTTTCCTGTCCCCTGCTGTCGGCAGGGTCTCGGCTCCGCTC
CTTCTAAGCGCGTGTACCCGCGACGTGCGTCTGCGAGTAGAAAGCCCGTGTACTGCTCCACACACAGCGGCCCCACCTCAGTCCGGTCTT
CCCTGCCTCCCGTTGGCCCTTCTGCTGTGAGCTCGCCTGGACCTGAGGCCGGGCGGTGCACAGCTCTGTGGCCTGTGGCGCCGTGCTCAG
CGTGACCTACCCAGAATTAAGCTGAGGACAATGGGATTTAGAGTCCCAAACACTCGCCCCGTGACAATGGGAGGGGAAGTGTCATTTTTC
TCCCTTCGAATGGAGCATGCTTGGCTGCAAGAATGCTGCTCAACATGGTGAAATGATTTTCTGCCCTGCGGGCTGGTGCACCCTGTGGTC
CTTGACCCAGACAGGTGCGGAGGGTCCCACTGCTGTGATTAGCAGAACCAAACTGTGATGTGCACATGTGTGTTACTGATAAGACCAGGC
CTCCCAGCTCTTCTTGGTTTCCAATGCCTGCTAAGTACATGACCTTCTTAGGGCCATTAACCAGCTTTGCTGTCTTGCACTTAATGACCT
TTCCTCTTTATCTTCCTTGTTGTGCAGGTAAAGAAGCTAAGTGGAAGAGTGTTTCCTCCTCTGGCCGTAAAGCAGCTGTCCCCGCCCTAC
TCCGGACCGCCCCAAAGACTCCATGGGATGGACCTGAGTCAGCCGAATCCCAGCCCCTTCCCTTGGGCCTGCTGTGGTGCTGGACATCAG
TGACAGACGGAAGCAGGAGACCATCAAGGCTACGGGAGGCCCGGGGCGCTTGCGAAGATGAAGTTTGGCTGCCTCTCCTTCCGGCAGCCT
TATGCTGGCTTTGTCTTAAATGGAATCAAGACTGTGGAGACGCGCTGGCGTCCCCTGCTGAGCAGCCAGCGGAACTGTACCATCGCCGTC
CACATTGCTCACAGGGACTGGGAAGGCGATGCCTGGCGGGAGCTGCTGGTGGAGAGACTCGGGATGACTCCTGCTCAGATTCAGACCTTG
CTCAGGAAAGGGGAAAAGTTTGGTCGAGGAGTGATAGCGGTGACCAACCTGAAGCAGAAGTACCTGACTGTGATTTCAAACCCCAGGTGG
TTACTGGAGCCCATACCTAGGAAAGGAGGCAAGGATGTATTCCAGGTAGACATCCCAGAGCACCTGATCCCATTGGGGCATGAAGTGTGA
CAAGTGTGGGCTCCTGAAAGGAATGTTCCAGAGAAACCAGCTAAATCATGACACCTTCAATTTGCCATCATGACGCAGACCTGTATACAT
TAGGTTAAATCTGAATTTCCACTGCTTTGGAGAGTCCCACCCACTAAGCACTGTGCATGTAAACAGGTTCCTTTGCTCAGATGAAGGAAG
TAGGGGGTGGGGCTTTCCTTGTGTGATGCCTCCTTAGGCACACAGGCAATGTCTCAAGTACTTTGACCTTAGGGTAGAAGGCAAAGCTGC
CAGTAAATGTCTCAGCATTGCTGCTAATTTTGGTCCTGCTAGTTTCTGGATTGTACAAATAAATGTGTTGTAGATGATACCCTGATGCTA
CAGACGAGGACATCACCTCACACATGGAAAGCGAGGAGTTGAATGGTGCATACAAGGCCATCCCCGTTGCCCAGGACCTGAACGCGCCTT
CTGATTGGGACAGCCGTGGGAAGGACAGTTATGAAACGAGTCAGCTGGATGACCAGAGTGCTGAAACCCACAGCCACAAGCAGTCCAGAT
TATATAAGCGGAAAGCCAATGATGAGAGCAATGAGCATTCCGATGTGATTGATAGTCAGGAACTTTCCAAAGTCAGCCGTGAATTCCACA
GCCATGAATTTCACAGCCATGAAGATATGCTGGTTGTAGACCCCAAAAGTAAGGAAGAAGATAAACACCTGAAATTTCGTATTTCTCATG
AATTAGATAGTGCATCTTCTGAGGTCAATTAAAAGGAGAAAAAATACAATTTCTCACTTTGCATTTAGTCAAAAGAAAAAATGCTTTATA
GCAAAATGAAAGAGAACATGAAATGCTTCTTTCTCAGTTTATTGGTTGAATGTGTATCTATTTGAGTCTGGAAATAACTAATGTGTTTGA
TAATTAGTTTAGTTTGTGGCTTCATGGAAACTCCCTGTAAACTAAAAGCTTCAGGGTTATGTCTATGTTCATTCTATAGAAGAAATGCAA
ACTATCACTGTATTTTAATATTTGTTATTCTCTCATGAATAGAAATTTATGTAGAAGCAAACAAAATACTTTTACCCACTTAAAAAGAGA
ATATAACATTTTATGTCACTATAATCTTTTGTTTTTTAAGTTAGTGTATATTTTGTTGTGATTATCTTTTTGTGGTGTGAATAAATCTTT
TATCTTGAATGTAATAAGAATTTGGTGGTGTCAATTGCTTATTTGTTTTCCCACGGTTGTCCAGCAATTAATAAAACATAACCTTTTTTA

>In-frame_ENST00000441248_ENST00000237623_AX184495_CXorf40A_chrX_148628368_+_SPP1_chr4_88903643_length(amino acids)=224AA_start in transcript=1235_stop in transcript=1909
MCVTDKTRPPSSSWFPMPAKYMTFLGPLTSFAVLHLMTFPLYLPCCAGKEAKWKSVSSSGRKAAVPALLRTAPKTPWDGPESAESQPLPL
GLLWCWTSVTDGSRRPSRLREARGACEDEVWLPLLPAALCWLCLKWNQDCGDALASPAEQPAELYHRRPHCSQGLGRRCLAGAAGGETRD

--------------------------------------------------------------
>In-frame_ENST00000393985_ENST00000360804_AX184495_CXorf40A_chrX_148628368_+_SPP1_chr4_88903643_length(transcript)=1700nt_BP=1064nt
GTTCTTCGTGAAAGGGATGACGGGAGCTGTATGAAAGCGGAAGAGTTATAGACCGCTAACACCTGTCACTGGCCACTGGTTTCCCGGAGT
TAGCGGCAACGACCTTGCAGCCTGGACACTAGCCAGGCGCTCCCTCTTCTCACAGCGGCCCACGTCTCCTTGCTTGGGAGCCCATCGTCC
TGGCTCCGGTGGCCTCGCTGGGTCTCGGGGAGGCAGAGGACTGTTCTTTCCTGTGGCGAAAAGCCGGAGTCGGCCCTAGACACCCACGAC
TCGCAGGGTCCATGGTTCCGGAGGCCGTGAGACCTGCCGGGGCTGACAGGTGCCAGGGCCCATGCTGCGGGAGCCTGTGTGCTCAGCCTT
CTTGCGGACGGTAAAGAAGCTAAGTGGAAGAGTGTTTCCTCCTCTGGCCGTAAAGCAGGTACTCTCTGCAGCACCAGCTGTCCCCGCCCT
ACTCCGGACCGCCCCAAAGACTCCATGGGATGGACCTGAGTCAGCCGAATCCCAGCCCCTTCCCTTGGGCCTGCTGTGGTGCTGGACATC
AGTGACAGACGGAAGCAGGAGACCATCAAGGCTACGGGAGGCCCGGGGCGCTTGCGAAGATGAAGTTTGGCTGCCTCTCCTTCCGGCAGC
CTTATGCTGGCTTTGTCTTAAATGGAATCAAGACTGTGGAGACGCGCTGGCGTCCCCTGCTGAGCAGCCAGCGGAACTGTACCATCGCCG
TCCACATTGCTCACAGGGACTGGGAAGGCGATGCCTGGCGGGAGCTGCTGGTGGAGAGACTCGGGATGACTCCTGCTCAGATTCAGACCT
TGCTCAGGAAAGGGGAAAAGTTTGGTCGAGGAGTGATAGCGGTGACCAACCTGAAGCAGAAGTACCTGACTGTGATTTCAAACCCCAGGT
GGTTACTGGAGCCCATACCTAGGAAAGGAGGCAAGGATGTATTCCAGGTAGACATCCCAGAGCACCTGATCCCATTGGGGCATGAAGTGT
GACAAGTGTGGGCTCCTGAAAGGAATGTTCCAGAGAAACCAGCTAAATCATGACACCTTCAATTTGCCATCATGTACCCTGATGCTACAG
ACGAGGACATCACCTCACACATGGAAAGCGAGGAGTTGAATGGTGCATACAAGGCCATCCCCGTTGCCCAGGACCTGAACGCGCCTTCTG
ATTGGGACAGCCGTGGGAAGGACAGTTATGAAACGAGTCAGCTGGATGACCAGAGTGCTGAAACCCACAGCCACAAGCAGTCCAGATTAT
ATAAGCGGAAAGCCAATGATGAGAGCAATGAGCATTCCGATGTGATTGATAGTCAGGAACTTTCCAAAGTCAGCCGTGAATTCCACAGCC
ATGAATTTCACAGCCATGAAGATATGCTGGTTGTAGACCCCAAAAGTAAGGAAGAAGATAAACACCTGAAATTTCGTATTTCTCATGAAT
TAGATAGTGCATCTTCTGAGGTCAATTAAAAGGAGAAAAAATACAATTTCTCACTTTGCATTTAGTCAAAAGAAAAAATGCTTTATAGCA
AAATGAAAGAGAACATGAAATGCTTCTTTCTCAGTTTATTGGTTGAATGTGTATCTATTTGAGTCTGGAAATAACTAATGTGTTTGATAA

>In-frame_ENST00000393985_ENST00000360804_AX184495_CXorf40A_chrX_148628368_+_SPP1_chr4_88903643_length(amino acids)=196AA_start in transcript=331_stop in transcript=921
MLREPVCSAFLRTVKKLSGRVFPPLAVKQVLSAAPAVPALLRTAPKTPWDGPESAESQPLPLGLLWCWTSVTDGSRRPSRLREARGACED
EVWLPLLPAALCWLCLKWNQDCGDALASPAEQPAELYHRRPHCSQGLGRRCLAGAAGGETRDDSCSDSDLAQERGKVWSRSDSGDQPEAE

--------------------------------------------------------------
>In-frame_ENST00000423421_ENST00000237623_AX184495_CXorf40A_chrX_148628368_+_SPP1_chr4_88903643_length(transcript)=2238nt_BP=1319nt
TTCTTCGTGAAAGGGATGACGGGAGCTGTATGAAAGCGGAAGAGTTATAGACCGCTAACACCTGTCACTGGCCACTGGTTTCCCGGAGTT
AGCGGCAACGACCTTGCAGCCTGGACACTAGCCAGGCGCTCCCTCTTCTCACAGCGGCCCACGTCTCCTTGCTTGGGAGCCCATCGTCCT
GGCTCCGGTGGCCTCGCTGGGTCTCGGGGAGGCAGAGGACTGTTCTTTCCTGTGGCGAAAAGCCGGAGTCGGCCCTAGACACCCACGACT
CGCAGGGTCCATGGTTCCGGAGGCCGTGAGACCTGCCGGGGCTGACAGGTGCCAGGGCCCATGCTGCGGGAGCCTGTGTGCTCAGCCTTC
TTGCGGACGGTAAAGAAGCTAAGTGGAAGAGTGTTTCCTCCTCTGGCCGTAAAGCAGCTGTCCCCGCCCTACTCCGGACCGCCCCAAAGA
CTCCATGGGATGGACCTGAGTCAGCCGAATCCCAGCCCCTTCCCTTGGGCCTGCTGTGGTGCTGGACATCAGTGACAGACGGAAGCAGGA
GACCATCAAGGCTACGGGAGGCCCGGGGCGCTTGCGAAGATGAAGTTTGGCTGCCTCTCCTTCCGGCAGCCTTATGCTGGCTTTGTCTTA
AATGGAATCAAGACTGTGGAGACGCGCTGGCGTCCCCTGCTGAGCAGCCAGCGGAACTGTACCATCGCCGTCCACATTGCTCACAGGGAC
TGGGAAGGCGATGCCTGGCGGGAGCTGCTGGTGGAGAGACTCGGGATGACTCCTGCTCAGATTCAGACCTTGCTCAGGAAAGGGGAAAAG
TTTGGTCGAGGAGTGATAGCGGTGACCAACCTGAAGCAGAAGTACCTGACTGTGATTTCAAACCCCAGGTGGTTACTGGAGCCCATACCT
AGGAAAGGAGGCAAGGATGTATTCCAGGTAGACATCCCAGAGCACCTGATCCCATTGGGGCATGAAGTGTGACAAGTGTGGGCTCCTGAA
AGGAATGTTCCAGAGAAACCAGCTAAATCATGACACCTTCAATTTGCCATCATGACGCAGACCTGTATACATTAGGTTAAATCTGAATTT
CCACTGCTTTGGAGAGTCCCACCCACTAAGCACTGTGCATGTAAACAGGTTCCTTTGCTCAGATGAAGGAAGTAGGGGGTGGGGCTTTCC
TTGTGTGATGCCTCCTTAGGCACACAGGCAATGTCTCAAGTACTTTGACCTTAGGGTAGAAGGCAAAGCTGCCAGTAAATGTCTCAGCAT
TGCTGCTAATTTTGGTCCTGCTAGTTTCTGGATTGTACAAATAAATGTGTTGTAGATGATACCCTGATGCTACAGACGAGGACATCACCT
CACACATGGAAAGCGAGGAGTTGAATGGTGCATACAAGGCCATCCCCGTTGCCCAGGACCTGAACGCGCCTTCTGATTGGGACAGCCGTG
GGAAGGACAGTTATGAAACGAGTCAGCTGGATGACCAGAGTGCTGAAACCCACAGCCACAAGCAGTCCAGATTATATAAGCGGAAAGCCA
ATGATGAGAGCAATGAGCATTCCGATGTGATTGATAGTCAGGAACTTTCCAAAGTCAGCCGTGAATTCCACAGCCATGAATTTCACAGCC
ATGAAGATATGCTGGTTGTAGACCCCAAAAGTAAGGAAGAAGATAAACACCTGAAATTTCGTATTTCTCATGAATTAGATAGTGCATCTT
CTGAGGTCAATTAAAAGGAGAAAAAATACAATTTCTCACTTTGCATTTAGTCAAAAGAAAAAATGCTTTATAGCAAAATGAAAGAGAACA
TGAAATGCTTCTTTCTCAGTTTATTGGTTGAATGTGTATCTATTTGAGTCTGGAAATAACTAATGTGTTTGATAATTAGTTTAGTTTGTG
GCTTCATGGAAACTCCCTGTAAACTAAAAGCTTCAGGGTTATGTCTATGTTCATTCTATAGAAGAAATGCAAACTATCACTGTATTTTAA
TATTTGTTATTCTCTCATGAATAGAAATTTATGTAGAAGCAAACAAAATACTTTTACCCACTTAAAAAGAGAATATAACATTTTATGTCA
CTATAATCTTTTGTTTTTTAAGTTAGTGTATATTTTGTTGTGATTATCTTTTTGTGGTGTGAATAAATCTTTTATCTTGAATGTAATAAG

>In-frame_ENST00000423421_ENST00000237623_AX184495_CXorf40A_chrX_148628368_+_SPP1_chr4_88903643_length(amino acids)=199AA_start in transcript=302_stop in transcript=901
MPGLTGARAHAAGACVLSLLADGKEAKWKSVSSSGRKAAVPALLRTAPKTPWDGPESAESQPLPLGLLWCWTSVTDGSRRPSRLREARGA
CEDEVWLPLLPAALCWLCLKWNQDCGDALASPAEQPAELYHRRPHCSQGLGRRCLAGAAGGETRDDSCSDSDLAQERGKVWSRSDSGDQP

--------------------------------------------------------------
>In-frame_ENST00000423540_ENST00000360804_AX184495_CXorf40A_chrX_148628368_+_SPP1_chr4_88903643_length(transcript)=1760nt_BP=1124nt
GAAAGGGATGACGGGAGCTGTATGAAAGCGGAAGAGTTATAGACCGCTAACACCTGTCACTGGCCACTGGTTTCCCGGAGTTAGCGGCAA
CGACCTTGCAGCCTGGACACTAGCCAGGCGCTCCCTCTTCTCACAGCGGCCCACGTCTCCTTGCTTGGGAGCCCATCGTCCTGGCTCCGG
TGGCCTCGCTGGGTCTCGGGGAGGCAGAGGACTGTTCTTTCCTGTGGCGAAAAGCCGGAGTCGGCCCTAGACACCCACGACTCGCAGGGT
CCATGGTTCCGGAGGCCGTGAGACCTGCCGGGGCTGACAGGTAAAGAAGCTAAGTGGAAGAGTGTTTCCTCCTCTGGCCGTAAAGCAGGT
ACTCTCTGCAGCACCAGCTGTCCCCGCCCTACTCCGGACCGCCCCAAAGACTCCATGGGATGGACCTGAGTCAGCCGAATCCCAGCCCCT
TCCCTTGGGCCTGCTGTGGTGCTGGACATCAGTGACAGACGGAAGCAGGAGACCATCAAGGCTACGGGAGGCCCGGGGCGCTTGCGAAGA
TGAAGTTTGGCTGCCTCTCCTTCCGGCAGCCTTATGCTGGCTTTGTCTTAAATGGAATCAAGACTGTGGAGACGCGCTGGCGTCCCCTGC
TGAGCAGCCAGCGGAACTGTACCATCGCCGTCCACATTGCTCACAGGGACTGGGAAGGCGATGCCTGGCGGGAGCTGCTGGTGGAGAGAC
TCGGGATGACTCCTGCTCAGATTCAGACCTTGCTCAGGAAAGGGGAAAAGTTTGGTCGAGGAGTGATAGCGGTGACCAACCTGAAGCAGA
AGTACCTGACTGTGATTTCAAACCCCAGGTGGTTACTGGAGCCCATACCTAGGAAAGGAGGCAAGGATGTATTCCAGGTAGACATCCCAG
AGCACCTGATCCCATTGGGGCATGAAGTGTGACAAGTGTGGGCTCCTGAAAGGAATGTTCCAGAGAAACCAGCTAAATCATGACACCTTC
AATTTGCCATCATGACGCAGACCTGTATACATTAGGTTAAATCTGAATTTCCACTGCTTTGGAGAGTCCCACCCACTAAGCACTGTGCAT
GTAAACAGGTTCCTTTGCTCAGATGAAGGAAGTAGGGGGTGGGGTACCCTGATGCTACAGACGAGGACATCACCTCACACATGGAAAGCG
AGGAGTTGAATGGTGCATACAAGGCCATCCCCGTTGCCCAGGACCTGAACGCGCCTTCTGATTGGGACAGCCGTGGGAAGGACAGTTATG
AAACGAGTCAGCTGGATGACCAGAGTGCTGAAACCCACAGCCACAAGCAGTCCAGATTATATAAGCGGAAAGCCAATGATGAGAGCAATG
AGCATTCCGATGTGATTGATAGTCAGGAACTTTCCAAAGTCAGCCGTGAATTCCACAGCCATGAATTTCACAGCCATGAAGATATGCTGG
TTGTAGACCCCAAAAGTAAGGAAGAAGATAAACACCTGAAATTTCGTATTTCTCATGAATTAGATAGTGCATCTTCTGAGGTCAATTAAA
AGGAGAAAAAATACAATTTCTCACTTTGCATTTAGTCAAAAGAAAAAATGCTTTATAGCAAAATGAAAGAGAACATGAAATGCTTCTTTC
TCAGTTTATTGGTTGAATGTGTATCTATTTGAGTCTGGAAATAACTAATGTGTTTGATAATTAGTTTAGTTTGTGGCTTCATGGAAACTC

>In-frame_ENST00000423540_ENST00000360804_AX184495_CXorf40A_chrX_148628368_+_SPP1_chr4_88903643_length(amino acids)=172AA_start in transcript=343_stop in transcript=861
MAVKQVLSAAPAVPALLRTAPKTPWDGPESAESQPLPLGLLWCWTSVTDGSRRPSRLREARGACEDEVWLPLLPAALCWLCLKWNQDCGD

--------------------------------------------------------------
>In-frame_ENST00000434353_ENST00000360804_AX184495_CXorf40A_chrX_148628368_+_SPP1_chr4_88903643_length(transcript)=1551nt_BP=915nt
GGGATGACGGGAGCTGTATGAAAGCGGAAGAGTTATAGACCGCTAACACCTGTCACTGGCCACTGGTTTCCCGGAGTTAGCGGCAACGAC
CTTGCAGCCTGGACACTAGCCAGGCGCTCCCTCTTCTCACAGCGGCCCACGTCTCCTTGCTTGGGAGCCCATCGTCCTGGCTCCGGTGGC
CTCGCTGGGTCTCGGGGAGGCAGAGGACTGTTCTTTCCTGTGGCGAAAAGCCGGAGTCGGCCCTAGACACCCACGACTCGCAGGGTCCAT
GGTTCCGGAGGCCGTGAGACCTGCCGGGGCTGACAGGTGCCAGGGCCCATGCTGCGGGAGCCTGTGTGCTCAGCCTTCTTGCGGACGGTA
AAGAAGCTAAGTGGAAGAGTGTTTCCTCCTCTGGCCGTAAAGCAGCTGTCCCCGCCCTACTCCGGACCGCCCCAAAGACTCCATGGGATG
GACCTGAGTCAGCCGAATCCCAGCCCCTTCCCTTGGGCCTGCTGTGGTGCTGGACATCAGTGACAGACGGAAGCAGGAGACCATCAAGGC
TACGGGAGGCCCGGGGCGCTTGCGAAGATGAAGTTTGGCTGCCTCTCCTTCCGGCAGCCTTATGCTGGCTTTGTCTTAAATGGAATCAAG
ACTGTGGAGACGCGCTGGCGTCCCCTGCTGAGCAGCCAGCGGAACTGTACCATCGCCGTCCACATTGCTCACAGGGACTGGGAAGGCGAT
GCCTGGCGGGAGCTGCTGGTGGAGAGACTCGGGATGACTCCTGCTCAGATTCAGACCTTGCTCAGGAAAGGGGAAAAGTTTGGTCGAGGA
GTGATAGCGGTGACCAACCTGAAGCAGAAGTACCTGACTGTGATTTCAAACCCCAGGTGGTTACTGGAGCCCATACCTAGGAAAGGAGGC
AAGGATGTATTCCAGTACCCTGATGCTACAGACGAGGACATCACCTCACACATGGAAAGCGAGGAGTTGAATGGTGCATACAAGGCCATC
CCCGTTGCCCAGGACCTGAACGCGCCTTCTGATTGGGACAGCCGTGGGAAGGACAGTTATGAAACGAGTCAGCTGGATGACCAGAGTGCT
GAAACCCACAGCCACAAGCAGTCCAGATTATATAAGCGGAAAGCCAATGATGAGAGCAATGAGCATTCCGATGTGATTGATAGTCAGGAA
CTTTCCAAAGTCAGCCGTGAATTCCACAGCCATGAATTTCACAGCCATGAAGATATGCTGGTTGTAGACCCCAAAAGTAAGGAAGAAGAT
AAACACCTGAAATTTCGTATTTCTCATGAATTAGATAGTGCATCTTCTGAGGTCAATTAAAAGGAGAAAAAATACAATTTCTCACTTTGC
ATTTAGTCAAAAGAAAAAATGCTTTATAGCAAAATGAAAGAGAACATGAAATGCTTCTTTCTCAGTTTATTGGTTGAATGTGTATCTATT
TGAGTCTGGAAATAACTAATGTGTTTGATAATTAGTTTAGTTTGTGGCTTCATGGAAACTCCCTGTAAACTAAAAGCTTCAGGGTTATGT

>In-frame_ENST00000434353_ENST00000360804_AX184495_CXorf40A_chrX_148628368_+_SPP1_chr4_88903643_length(amino acids)=250AA_start in transcript=567_stop in transcript=1319
MKFGCLSFRQPYAGFVLNGIKTVETRWRPLLSSQRNCTIAVHIAHRDWEGDAWRELLVERLGMTPAQIQTLLRKGEKFGRGVIAVTNLKQ
KYLTVISNPRWLLEPIPRKGGKDVFQYPDATDEDITSHMESEELNGAYKAIPVAQDLNAPSDWDSRGKDSYETSQLDDQSAETHSHKQSR

--------------------------------------------------------------
>In-frame_ENST00000514208_ENST00000360804_AX184495_CXorf40A_chrX_148628368_+_SPP1_chr4_88903643_length(transcript)=1297nt_BP=661nt
GACCGCTAACACCTGTCACTGGCCACTGGTTTCCCGGAGTTAGCGGCAACGACCTTGCAGCCTGGACACTAGCCAGGCGCTCCCTCTTCT
CACAGCGGCCCACGTAAAGAAGCTAAGTGGAAGAGTGTTTCCTCCTCTGGCCGTAAAGCAGCTGTCCCCGCCCTACTCCGGACCGCCCCA
AAGACTCCATGGGATGGACCTGAGTCAGCCGAATCCCAGCCCCTTCCCTTGGGCCTGCTGTGGTGCTGGACATCAGTGACAGACGGAAGC
AGGAGACCATCAAGGCTACGGGAGGCCCGGGGCGCTTGCGAAGATGAAGTTTGGCTGCCTCTCCTTCCGGCAGCCTTATGCTGGCTTTGT
CTTAAATGGAATCAAGACTGTGGAGACGCGCTGGCGTCCCCTGCTGAGCAGCCAGCGGAACTGTACCATCGCCGTCCACATTGCTCACAG
GGACTGGGAAGGCGATGCCTGGCGGGAGCTGCTGGTGGAGAGACTCGGGATGACTCCTGCTCAGATTCAGACCTTGCTCAGGAAAGGGGA
AAAGTTTGGTCGAGGAGTGATAGCGGTGACCAACCTGAAGCAGAAGTACCTGACTGTGATTTCAAACCCCAGGTGGTTACTGGAGCCCAT
ACCTAGGAAAGGAGGCAAGGATGTATTCCAGTACCCTGATGCTACAGACGAGGACATCACCTCACACATGGAAAGCGAGGAGTTGAATGG
TGCATACAAGGCCATCCCCGTTGCCCAGGACCTGAACGCGCCTTCTGATTGGGACAGCCGTGGGAAGGACAGTTATGAAACGAGTCAGCT
GGATGACCAGAGTGCTGAAACCCACAGCCACAAGCAGTCCAGATTATATAAGCGGAAAGCCAATGATGAGAGCAATGAGCATTCCGATGT
GATTGATAGTCAGGAACTTTCCAAAGTCAGCCGTGAATTCCACAGCCATGAATTTCACAGCCATGAAGATATGCTGGTTGTAGACCCCAA
AAGTAAGGAAGAAGATAAACACCTGAAATTTCGTATTTCTCATGAATTAGATAGTGCATCTTCTGAGGTCAATTAAAAGGAGAAAAAATA
CAATTTCTCACTTTGCATTTAGTCAAAAGAAAAAATGCTTTATAGCAAAATGAAAGAGAACATGAAATGCTTCTTTCTCAGTTTATTGGT
TGAATGTGTATCTATTTGAGTCTGGAAATAACTAATGTGTTTGATAATTAGTTTAGTTTGTGGCTTCATGGAAACTCCCTGTAAACTAAA

>In-frame_ENST00000514208_ENST00000360804_AX184495_CXorf40A_chrX_148628368_+_SPP1_chr4_88903643_length(amino acids)=250AA_start in transcript=313_stop in transcript=1065
MKFGCLSFRQPYAGFVLNGIKTVETRWRPLLSSQRNCTIAVHIAHRDWEGDAWRELLVERLGMTPAQIQTLLRKGEKFGRGVIAVTNLKQ
KYLTVISNPRWLLEPIPRKGGKDVFQYPDATDEDITSHMESEELNGAYKAIPVAQDLNAPSDWDSRGKDSYETSQLDDQSAETHSHKQSR

--------------------------------------------------------------
>In-frame_ENST00000428236_ENST00000237623_AX184495_CXorf40A_chrX_148628368_+_SPP1_chr4_88903643_length(transcript)=1722nt_BP=803nt
GTAAAGAAGCTAAGTGGAAGAGTGTTTCCTCCTCTGGCCGTAAAGCAGGTACTCTCTGCAGCACCAGCTGTCCCCGCCCTACTCCGGACC
GCCCCAAAGACTCCATGGGATGGACCTGAGTCAGCCGAATCCCAGCCCCTTCCCTTGGGCCTGCTGTGGTGCTGGACATCAGTGACAGAC
GGAAGCAGGAGACCATCAAGGGACTGGGAAGGCGATGCCTGGCGGGAGCTGCTGGTGGAGAGACTCGGGATGACTCCTGCTCAGATTCAG
ACCTTGCTCAGGAAAGGGGAAAAGTTTGGTCGAGGAGTGATAGCGGTGACCAACCTGAAGCAGAAGTACCTGACTGTGATTTCAAACCCC
AGGTGGTTACTGGAGCCCATACCTAGGAAAGGAGGCAAGGATGTATTCCAGGTAGACATCCCAGAGCACCTGATCCCATTGGGGCATGAA
GTGTGACAAGTGTGGGCTCCTGAAAGGAATGTTCCAGAGAAACCAGCTAAATCATGACACCTTCAATTTGCCATCATGACGCAGACCTGT
ATACATTAGGTTAAATCTGAATTTCCACTGCTTTGGAGAGTCCCACCCACTAAGCACTGTGCATGTAAACAGGTTCCTTTGCTCAGATGA
AGGAAGTAGGGGGTGGGGCTTTCCTTGTGTGATGCCTCCTTAGGCACACAGGCAATGTCTCAAGTACTTTGACCTTAGGGTAGAAGGCAA
AGCTGCCAGTAAATGTCTCAGCATTGCTGCTAATTTTGGTCCTGCTAGTTTCTGGATTGTACAAATAAATGTGTTGTAGATGATACCCTG
ATGCTACAGACGAGGACATCACCTCACACATGGAAAGCGAGGAGTTGAATGGTGCATACAAGGCCATCCCCGTTGCCCAGGACCTGAACG
CGCCTTCTGATTGGGACAGCCGTGGGAAGGACAGTTATGAAACGAGTCAGCTGGATGACCAGAGTGCTGAAACCCACAGCCACAAGCAGT
CCAGATTATATAAGCGGAAAGCCAATGATGAGAGCAATGAGCATTCCGATGTGATTGATAGTCAGGAACTTTCCAAAGTCAGCCGTGAAT
TCCACAGCCATGAATTTCACAGCCATGAAGATATGCTGGTTGTAGACCCCAAAAGTAAGGAAGAAGATAAACACCTGAAATTTCGTATTT
CTCATGAATTAGATAGTGCATCTTCTGAGGTCAATTAAAAGGAGAAAAAATACAATTTCTCACTTTGCATTTAGTCAAAAGAAAAAATGC
TTTATAGCAAAATGAAAGAGAACATGAAATGCTTCTTTCTCAGTTTATTGGTTGAATGTGTATCTATTTGAGTCTGGAAATAACTAATGT
GTTTGATAATTAGTTTAGTTTGTGGCTTCATGGAAACTCCCTGTAAACTAAAAGCTTCAGGGTTATGTCTATGTTCATTCTATAGAAGAA
ATGCAAACTATCACTGTATTTTAATATTTGTTATTCTCTCATGAATAGAAATTTATGTAGAAGCAAACAAAATACTTTTACCCACTTAAA
AAGAGAATATAACATTTTATGTCACTATAATCTTTTGTTTTTTAAGTTAGTGTATATTTTGTTGTGATTATCTTTTTGTGGTGTGAATAA
ATCTTTTATCTTGAATGTAATAAGAATTTGGTGGTGTCAATTGCTTATTTGTTTTCCCACGGTTGTCCAGCAATTAATAAAACATAACCT

>In-frame_ENST00000428236_ENST00000237623_AX184495_CXorf40A_chrX_148628368_+_SPP1_chr4_88903643_length(amino acids)=140AA_start in transcript=33_stop in transcript=455
MAVKQVLSAAPAVPALLRTAPKTPWDGPESAESQPLPLGLLWCWTSVTDGSRRPSRDWEGDAWRELLVERLGMTPAQIQTLLRKGEKFGR

--------------------------------------------------------------
>In-frame_ENST00000422892_ENST00000360804_AX184495_CXorf40A_chrX_148628368_+_SPP1_chr4_88903643_length(transcript)=1511nt_BP=875nt
ATTAGGTGCCACGTACTGGGCTGGGTGCTCTTGGTGCCTTATCTCCCTTCCTCACAGCCATGTGGAAACTGAGGCATCTCAAGAGTCTAT
GACTGGGCTGAGGTTCTGGTTTCGAGCCCAGGGTTCCTTCCAAGGCACAGGGCCGTCCTCCATGCAAGAGGAGGGGACCCTCTCCCAAGC
CACACACGCAGGAGGCTGGGCAAGAGTTGTGGGAAGTCAGAGCCCGTGTGACTGTGGGCTGGTGCCTCATTCTCCTCAGCCATAGAGTGG
GCCTCACAGTACCACTGACCCTGCTGGGTTACTTGAAGATTCAATTTGATGATCCGAGGATCATGCCATCCCAGAGGCTGGCACGTGGAA
GGCATCTGTCCCCGCCCTACTCCGGACCGCCCCAAAGACTCCATGGGATGGACCTGAGTCAGCCGAATCCCAGCCCCTTCCCTTGGGCCT
GCTGTGGTGCTGGACATCAGTGACAGACGGAAGCAGGAGACCATCAAGGCTACGGGAGGCCCGGGGCGCTTGCGAAGATGAAGTTTGGCT
GCCTCTCCTTCCGGCAGCCTTATGCTGGCTTTGTCTTAAATGGAATCAAGACTGTGGAGACGCGCTGGCGTCCCCTGCTGAGCAGCCAGC
GGAACTGTACCATCGCCGTCCACATTGCTCACAGGGACTGGGAAGGCGATGCCTGGCGGGAGCTGCTGGTGGAGAGACTCGGGATGACTC
CTGCTCAGATTCAGACCTTGCTCAGGAAAGGGGAAAAGTTTGGTCGAGGAGTGATAGCGGTGACCAACCTGAAGCAGAAGTACCTGACTG
TGATTTCAAACCCCAGGTGGTTACTGGAGCCCATACCTAGGAAAGGAGGCAAGGATGTATTCCAGTACCCTGATGCTACAGACGAGGACA
TCACCTCACACATGGAAAGCGAGGAGTTGAATGGTGCATACAAGGCCATCCCCGTTGCCCAGGACCTGAACGCGCCTTCTGATTGGGACA
GCCGTGGGAAGGACAGTTATGAAACGAGTCAGCTGGATGACCAGAGTGCTGAAACCCACAGCCACAAGCAGTCCAGATTATATAAGCGGA
AAGCCAATGATGAGAGCAATGAGCATTCCGATGTGATTGATAGTCAGGAACTTTCCAAAGTCAGCCGTGAATTCCACAGCCATGAATTTC
ACAGCCATGAAGATATGCTGGTTGTAGACCCCAAAAGTAAGGAAGAAGATAAACACCTGAAATTTCGTATTTCTCATGAATTAGATAGTG
CATCTTCTGAGGTCAATTAAAAGGAGAAAAAATACAATTTCTCACTTTGCATTTAGTCAAAAGAAAAAATGCTTTATAGCAAAATGAAAG
AGAACATGAAATGCTTCTTTCTCAGTTTATTGGTTGAATGTGTATCTATTTGAGTCTGGAAATAACTAATGTGTTTGATAATTAGTTTAG

>In-frame_ENST00000422892_ENST00000360804_AX184495_CXorf40A_chrX_148628368_+_SPP1_chr4_88903643_length(amino acids)=250AA_start in transcript=527_stop in transcript=1279
MKFGCLSFRQPYAGFVLNGIKTVETRWRPLLSSQRNCTIAVHIAHRDWEGDAWRELLVERLGMTPAQIQTLLRKGEKFGRGVIAVTNLKQ
KYLTVISNPRWLLEPIPRKGGKDVFQYPDATDEDITSHMESEELNGAYKAIPVAQDLNAPSDWDSRGKDSYETSQLDDQSAETHSHKQSR

--------------------------------------------------------------
>In-frame_ENST00000359293_ENST00000237623_AX184495_CXorf40A_chrX_148628368_+_SPP1_chr4_88903643_length(transcript)=1809nt_BP=890nt
GACGGAAGCAGGAGACCATCAAGGTCAGTGCGATTTAGGCCACCTGAGAGACACGGGGGGAAGGTCAGGCCACTGCCCATGAGCTTGGAG
GGCTGGCGTGTGATGCGCTTCTGTGCTTCCGCAGGCTACGGGAGGCCCGGGGCGCTTGCGAAGATGAAGTTTGGCTGCCTCTCCTTCCGG
CAGCCTTATGCTGGCTTTGTCTTAAATGGAATCAAGACTGTGGAGACGCGCTGGCGTCCCCTGCTGAGCAGCCAGCGGAACTGTACCATC
GCCGTCCACATTGCTCACAGGGACTGGGAAGGCGATGCCTGGCGGGAGCTGCTGGTGGAGAGACTCGGGATGACTCCTGCTCAGATTCAG
ACCTTGCTCAGGAAAGGGGAAAAGTTTGGTCGAGGAGTGATAGCGGTGACCAACCTGAAGCAGAAGTACCTGACTGTGATTTCAAACCCC
AGGTGGTTACTGGAGCCCATACCTAGGAAAGGAGGCAAGGATGTATTCCAGGTAGACATCCCAGAGCACCTGATCCCATTGGGGCATGAA
GTGTGACAAGTGTGGGCTCCTGAAAGGAATGTTCCAGAGAAACCAGCTAAATCATGACACCTTCAATTTGCCATCATGACGCAGACCTGT
ATACATTAGGTTAAATCTGAATTTCCACTGCTTTGGAGAGTCCCACCCACTAAGCACTGTGCATGTAAACAGGTTCCTTTGCTCAGATGA
AGGAAGTAGGGGGTGGGGCTTTCCTTGTGTGATGCCTCCTTAGGCACACAGGCAATGTCTCAAGTACTTTGACCTTAGGGTAGAAGGCAA
AGCTGCCAGTAAATGTCTCAGCATTGCTGCTAATTTTGGTCCTGCTAGTTTCTGGATTGTACAAATAAATGTGTTGTAGATACCCTGATG
CTACAGACGAGGACATCACCTCACACATGGAAAGCGAGGAGTTGAATGGTGCATACAAGGCCATCCCCGTTGCCCAGGACCTGAACGCGC
CTTCTGATTGGGACAGCCGTGGGAAGGACAGTTATGAAACGAGTCAGCTGGATGACCAGAGTGCTGAAACCCACAGCCACAAGCAGTCCA
GATTATATAAGCGGAAAGCCAATGATGAGAGCAATGAGCATTCCGATGTGATTGATAGTCAGGAACTTTCCAAAGTCAGCCGTGAATTCC
ACAGCCATGAATTTCACAGCCATGAAGATATGCTGGTTGTAGACCCCAAAAGTAAGGAAGAAGATAAACACCTGAAATTTCGTATTTCTC
ATGAATTAGATAGTGCATCTTCTGAGGTCAATTAAAAGGAGAAAAAATACAATTTCTCACTTTGCATTTAGTCAAAAGAAAAAATGCTTT
ATAGCAAAATGAAAGAGAACATGAAATGCTTCTTTCTCAGTTTATTGGTTGAATGTGTATCTATTTGAGTCTGGAAATAACTAATGTGTT
TGATAATTAGTTTAGTTTGTGGCTTCATGGAAACTCCCTGTAAACTAAAAGCTTCAGGGTTATGTCTATGTTCATTCTATAGAAGAAATG
CAAACTATCACTGTATTTTAATATTTGTTATTCTCTCATGAATAGAAATTTATGTAGAAGCAAACAAAATACTTTTACCCACTTAAAAAG
AGAATATAACATTTTATGTCACTATAATCTTTTGTTTTTTAAGTTAGTGTATATTTTGTTGTGATTATCTTTTTGTGGTGTGAATAAATC
TTTTATCTTGAATGTAATAAGAATTTGGTGGTGTCAATTGCTTATTTGTTTTCCCACGGTTGTCCAGCAATTAATAAAACATAACCTTTT

>In-frame_ENST00000359293_ENST00000237623_AX184495_CXorf40A_chrX_148628368_+_SPP1_chr4_88903643_length(amino acids)=157AA_start in transcript=72_stop in transcript=545
MPMSLEGWRVMRFCASAGYGRPGALAKMKFGCLSFRQPYAGFVLNGIKTVETRWRPLLSSQRNCTIAVHIAHRDWEGDAWRELLVERLGM

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Fusion Gene PPI Analysis for CXorf40A-SPP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CXorf40A-SPP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CXorf40A-SPP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSPP1C0024141Lupus Erythematosus, Systemic5ORPHANET
TgeneSPP1C0001418Adenocarcinoma2CTD_human
TgeneSPP1C0003949Asbestosis2CTD_human
TgeneSPP1C0006142Malignant neoplasm of breast2CTD_human
TgeneSPP1C0006663Calcinosis2CTD_human
TgeneSPP1C0022650Kidney Calculi2CTD_human
TgeneSPP1C0022660Kidney Failure, Acute2CTD_human
TgeneSPP1C0024121Lung Neoplasms2CTD_human
TgeneSPP1C0025500Mesothelioma2CTD_human
TgeneSPP1C0205641Adenocarcinoma, Basal Cell2CTD_human
TgeneSPP1C0205642Adenocarcinoma, Oxyphilic2CTD_human
TgeneSPP1C0205643Carcinoma, Cribriform2CTD_human
TgeneSPP1C0205644Carcinoma, Granular Cell2CTD_human
TgeneSPP1C0205645Adenocarcinoma, Tubular2CTD_human
TgeneSPP1C0242379Malignant neoplasm of lung2CTD_human
TgeneSPP1C0263628Tumoral calcinosis2CTD_human
TgeneSPP1C0521174Microcalcification2CTD_human
TgeneSPP1C0678222Breast Carcinoma2CTD_human
TgeneSPP1C1257931Mammary Neoplasms, Human2CTD_human
TgeneSPP1C1458155Mammary Neoplasms2CTD_human
TgeneSPP1C1565662Acute Kidney Insufficiency2CTD_human
TgeneSPP1C2609414Acute kidney injury2CTD_human
TgeneSPP1C2930617Pulmonary Fibrosis - from Asbestos Exposure2CTD_human
TgeneSPP1C4704874Mammary Carcinoma, Human2CTD_human
TgeneSPP1C0006118Brain Neoplasms1CTD_human
TgeneSPP1C0007282Carotid Stenosis1CTD_human
TgeneSPP1C0013221Drug toxicity1CTD_human
TgeneSPP1C0017638Glioma1CTD_human
TgeneSPP1C0017668Focal glomerulosclerosis1CTD_human
TgeneSPP1C0018799Heart Diseases1CTD_human
TgeneSPP1C0018824Heart valve disease1CTD_human
TgeneSPP1C0019193Hepatitis, Toxic1CTD_human
TgeneSPP1C0019207Hepatoma, Morris1CTD_human
TgeneSPP1C0019208Hepatoma, Novikoff1CTD_human
TgeneSPP1C0020517Hypersensitivity1CTD_human
TgeneSPP1C0022658Kidney Diseases1CTD_human
TgeneSPP1C0023890Liver Cirrhosis1CTD_human
TgeneSPP1C0023896Alcoholic Liver Diseases1CTD_human
TgeneSPP1C0023904Liver Neoplasms, Experimental1CTD_human
TgeneSPP1C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneSPP1C0027627Neoplasm Metastasis1CTD_human
TgeneSPP1C0027659Neoplasms, Experimental1CTD_human
TgeneSPP1C0030286Pancreatic Diseases1CTD_human
TgeneSPP1C0032229Pleural Neoplasms1CTD_human
TgeneSPP1C0032285Pneumonia1CTD_human
TgeneSPP1C0032300Lobar Pneumonia1CTD_human
TgeneSPP1C0033687Proteinuria1CTD_human
TgeneSPP1C0034069Pulmonary Fibrosis1CTD_human
TgeneSPP1C0041755Adverse reaction to drug1CTD_human
TgeneSPP1C0041948Uremia1CTD_human
TgeneSPP1C0086404Experimental Hepatoma1CTD_human
TgeneSPP1C0086432Hyalinosis, Segmental Glomerular1CTD_human
TgeneSPP1C0153633Malignant neoplasm of brain1CTD_human
TgeneSPP1C0162820Dermatitis, Allergic Contact1CTD_human
TgeneSPP1C0239946Fibrosis, Liver1CTD_human
TgeneSPP1C0259783mixed gliomas1CTD_human
TgeneSPP1C0270612Leukoencephalopathy1CTD_human
TgeneSPP1C0340569Internal Carotid Artery Stenosis1CTD_human
TgeneSPP1C0496899Benign neoplasm of brain, unspecified1CTD_human
TgeneSPP1C0555198Malignant Glioma1CTD_human
TgeneSPP1C0750974Brain Tumor, Primary1CTD_human
TgeneSPP1C0750977Recurrent Brain Neoplasm1CTD_human
TgeneSPP1C0750979Primary malignant neoplasm of brain1CTD_human
TgeneSPP1C0751633Carotid Artery Plaque1CTD_human
TgeneSPP1C0751634Carotid Ulcer1CTD_human
TgeneSPP1C0751635Common Carotid Artery Stenosis1CTD_human
TgeneSPP1C0751636External Carotid Artery Stenosis1CTD_human
TgeneSPP1C0853897Diabetic Cardiomyopathies1CTD_human
TgeneSPP1C0860207Drug-Induced Liver Disease1CTD_human
TgeneSPP1C0887898Experimental Lung Inflammation1CTD_human
TgeneSPP1C1262760Hepatitis, Drug-Induced1CTD_human
TgeneSPP1C1527304Allergic Reaction1CTD_human
TgeneSPP1C1527390Neoplasms, Intracranial1CTD_human
TgeneSPP1C1858991Childhood Ataxia with Central Nervous System Hypomyelinization1CTD_human
TgeneSPP1C2937358Cerebral Hemorrhage1CTD_human
TgeneSPP1C3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneSPP1C3714636Pneumonitis1CTD_human
TgeneSPP1C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneSPP1C4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneSPP1C4721411Osteolysis1CTD_human
TgeneSPP1C4721507Alveolitis, Fibrosing1CTD_human