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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADAM15-FLAD1 (FusionGDB2 ID:2090)

Fusion Gene Summary for ADAM15-FLAD1

check button Fusion gene summary
Fusion gene informationFusion gene name: ADAM15-FLAD1
Fusion gene ID: 2090
HgeneTgene
Gene symbol

ADAM15

FLAD1

Gene ID

8751

80308

Gene nameADAM metallopeptidase domain 15flavin adenine dinucleotide synthetase 1
SynonymsMDC15FAD1|FADS|LSMFLAD|PP591
Cytomap

1q21.3

1q21.3

Type of geneprotein-codingprotein-coding
Descriptiondisintegrin and metalloproteinase domain-containing protein 15MDC-15a disintegrin and metalloproteinase domain 15 (metargidin)metalloprotease RGD disintegrin proteinmetalloproteinase-like, disintegrin-like, and cysteine-rich protein 15FAD synthaseFAD pyrophosphorylaseFAD-synthetaseFMN adenylyltransferaseFad1, flavin adenine dinucleotide synthetase, homolog
Modification date2020032020200313
UniProtAcc

Q13444

Q8NFF5

Ensembl transtripts involved in fusion geneENST00000449910, ENST00000368412, 
ENST00000359280, ENST00000356955, 
ENST00000355956, ENST00000360674, 
ENST00000368410, ENST00000271836, 
ENST00000368413, ENST00000531455, 
ENST00000447332, ENST00000472434, 
ENST00000368433, ENST00000315144, 
ENST00000368432, ENST00000368431, 
ENST00000292180, ENST00000487371, 
ENST00000405236, ENST00000295530, 
ENST00000368428, 
Fusion gene scores* DoF score6 X 6 X 5=1809 X 9 X 6=486
# samples 710
** MAII scorelog2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/486*10)=-2.28095631383106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADAM15 [Title/Abstract] AND FLAD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADAM15(155029577)-FLAD1(154962635), # samples:1
Anticipated loss of major functional domain due to fusion event.ADAM15-FLAD1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ADAM15-FLAD1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ADAM15-FLAD1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADAM15

GO:0002418

immune response to tumor cell

22505472

HgeneADAM15

GO:0006915

apoptotic process

22505472

HgeneADAM15

GO:0045087

innate immune response

22505472

HgeneADAM15

GO:1904628

cellular response to phorbol 13-acetate 12-myristate

22505472


check buttonFusion gene breakpoints across ADAM15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FLAD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A1AN-01AADAM15chr1

155029577

+FLAD1chr1

154962635

+


Top

Fusion Gene ORF analysis for ADAM15-FLAD1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000449910ENST00000368433ADAM15chr1

155029577

+FLAD1chr1

154962635

+
In-frameENST00000449910ENST00000315144ADAM15chr1

155029577

+FLAD1chr1

154962635

+
In-frameENST00000449910ENST00000368432ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000449910ENST00000368431ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000449910ENST00000292180ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000449910ENST00000487371ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000449910ENST00000405236ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000449910ENST00000295530ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-5UTRENST00000449910ENST00000368428ADAM15chr1

155029577

+FLAD1chr1

154962635

+
Frame-shiftENST00000368412ENST00000368433ADAM15chr1

155029577

+FLAD1chr1

154962635

+
In-frameENST00000368412ENST00000315144ADAM15chr1

155029577

+FLAD1chr1

154962635

+
In-frameENST00000368412ENST00000368432ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000368412ENST00000368431ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000368412ENST00000292180ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000368412ENST00000487371ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000368412ENST00000405236ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000368412ENST00000295530ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-5UTRENST00000368412ENST00000368428ADAM15chr1

155029577

+FLAD1chr1

154962635

+
Frame-shiftENST00000359280ENST00000368433ADAM15chr1

155029577

+FLAD1chr1

154962635

+
In-frameENST00000359280ENST00000315144ADAM15chr1

155029577

+FLAD1chr1

154962635

+
In-frameENST00000359280ENST00000368432ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000359280ENST00000368431ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000359280ENST00000292180ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000359280ENST00000487371ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000359280ENST00000405236ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000359280ENST00000295530ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-5UTRENST00000359280ENST00000368428ADAM15chr1

155029577

+FLAD1chr1

154962635

+
Frame-shiftENST00000356955ENST00000368433ADAM15chr1

155029577

+FLAD1chr1

154962635

+
In-frameENST00000356955ENST00000315144ADAM15chr1

155029577

+FLAD1chr1

154962635

+
In-frameENST00000356955ENST00000368432ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000356955ENST00000368431ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000356955ENST00000292180ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000356955ENST00000487371ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000356955ENST00000405236ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000356955ENST00000295530ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-5UTRENST00000356955ENST00000368428ADAM15chr1

155029577

+FLAD1chr1

154962635

+
Frame-shiftENST00000355956ENST00000368433ADAM15chr1

155029577

+FLAD1chr1

154962635

+
In-frameENST00000355956ENST00000315144ADAM15chr1

155029577

+FLAD1chr1

154962635

+
In-frameENST00000355956ENST00000368432ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000355956ENST00000368431ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000355956ENST00000292180ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000355956ENST00000487371ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000355956ENST00000405236ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000355956ENST00000295530ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-5UTRENST00000355956ENST00000368428ADAM15chr1

155029577

+FLAD1chr1

154962635

+
Frame-shiftENST00000360674ENST00000368433ADAM15chr1

155029577

+FLAD1chr1

154962635

+
In-frameENST00000360674ENST00000315144ADAM15chr1

155029577

+FLAD1chr1

154962635

+
In-frameENST00000360674ENST00000368432ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000360674ENST00000368431ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000360674ENST00000292180ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000360674ENST00000487371ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000360674ENST00000405236ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000360674ENST00000295530ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-5UTRENST00000360674ENST00000368428ADAM15chr1

155029577

+FLAD1chr1

154962635

+
intron-3CDSENST00000368410ENST00000368433ADAM15chr1

155029577

+FLAD1chr1

154962635

+
intron-3CDSENST00000368410ENST00000315144ADAM15chr1

155029577

+FLAD1chr1

154962635

+
intron-3CDSENST00000368410ENST00000368432ADAM15chr1

155029577

+FLAD1chr1

154962635

+
intron-intronENST00000368410ENST00000368431ADAM15chr1

155029577

+FLAD1chr1

154962635

+
intron-intronENST00000368410ENST00000292180ADAM15chr1

155029577

+FLAD1chr1

154962635

+
intron-intronENST00000368410ENST00000487371ADAM15chr1

155029577

+FLAD1chr1

154962635

+
intron-intronENST00000368410ENST00000405236ADAM15chr1

155029577

+FLAD1chr1

154962635

+
intron-intronENST00000368410ENST00000295530ADAM15chr1

155029577

+FLAD1chr1

154962635

+
intron-5UTRENST00000368410ENST00000368428ADAM15chr1

155029577

+FLAD1chr1

154962635

+
Frame-shiftENST00000271836ENST00000368433ADAM15chr1

155029577

+FLAD1chr1

154962635

+
In-frameENST00000271836ENST00000315144ADAM15chr1

155029577

+FLAD1chr1

154962635

+
In-frameENST00000271836ENST00000368432ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000271836ENST00000368431ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000271836ENST00000292180ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000271836ENST00000487371ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000271836ENST00000405236ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000271836ENST00000295530ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-5UTRENST00000271836ENST00000368428ADAM15chr1

155029577

+FLAD1chr1

154962635

+
intron-3CDSENST00000368413ENST00000368433ADAM15chr1

155029577

+FLAD1chr1

154962635

+
intron-3CDSENST00000368413ENST00000315144ADAM15chr1

155029577

+FLAD1chr1

154962635

+
intron-3CDSENST00000368413ENST00000368432ADAM15chr1

155029577

+FLAD1chr1

154962635

+
intron-intronENST00000368413ENST00000368431ADAM15chr1

155029577

+FLAD1chr1

154962635

+
intron-intronENST00000368413ENST00000292180ADAM15chr1

155029577

+FLAD1chr1

154962635

+
intron-intronENST00000368413ENST00000487371ADAM15chr1

155029577

+FLAD1chr1

154962635

+
intron-intronENST00000368413ENST00000405236ADAM15chr1

155029577

+FLAD1chr1

154962635

+
intron-intronENST00000368413ENST00000295530ADAM15chr1

155029577

+FLAD1chr1

154962635

+
intron-5UTRENST00000368413ENST00000368428ADAM15chr1

155029577

+FLAD1chr1

154962635

+
Frame-shiftENST00000531455ENST00000368433ADAM15chr1

155029577

+FLAD1chr1

154962635

+
In-frameENST00000531455ENST00000315144ADAM15chr1

155029577

+FLAD1chr1

154962635

+
In-frameENST00000531455ENST00000368432ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000531455ENST00000368431ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000531455ENST00000292180ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000531455ENST00000487371ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000531455ENST00000405236ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000531455ENST00000295530ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-5UTRENST00000531455ENST00000368428ADAM15chr1

155029577

+FLAD1chr1

154962635

+
Frame-shiftENST00000447332ENST00000368433ADAM15chr1

155029577

+FLAD1chr1

154962635

+
In-frameENST00000447332ENST00000315144ADAM15chr1

155029577

+FLAD1chr1

154962635

+
In-frameENST00000447332ENST00000368432ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000447332ENST00000368431ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000447332ENST00000292180ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000447332ENST00000487371ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000447332ENST00000405236ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-intronENST00000447332ENST00000295530ADAM15chr1

155029577

+FLAD1chr1

154962635

+
5CDS-5UTRENST00000447332ENST00000368428ADAM15chr1

155029577

+FLAD1chr1

154962635

+
3UTR-3CDSENST00000472434ENST00000368433ADAM15chr1

155029577

+FLAD1chr1

154962635

+
3UTR-3CDSENST00000472434ENST00000315144ADAM15chr1

155029577

+FLAD1chr1

154962635

+
3UTR-3CDSENST00000472434ENST00000368432ADAM15chr1

155029577

+FLAD1chr1

154962635

+
3UTR-intronENST00000472434ENST00000368431ADAM15chr1

155029577

+FLAD1chr1

154962635

+
3UTR-intronENST00000472434ENST00000292180ADAM15chr1

155029577

+FLAD1chr1

154962635

+
3UTR-intronENST00000472434ENST00000487371ADAM15chr1

155029577

+FLAD1chr1

154962635

+
3UTR-intronENST00000472434ENST00000405236ADAM15chr1

155029577

+FLAD1chr1

154962635

+
3UTR-intronENST00000472434ENST00000295530ADAM15chr1

155029577

+FLAD1chr1

154962635

+
3UTR-5UTRENST00000472434ENST00000368428ADAM15chr1

155029577

+FLAD1chr1

154962635

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ADAM15-FLAD1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ADAM15chr1155029577+FLAD1chr1154962634+0.99813060.001869442
ADAM15chr1155029577+FLAD1chr1154962634+0.99813060.001869442

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ADAM15-FLAD1


check button Go to

FGviewer for the breakpoints of chr1:155029577-chr1:154962635

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADAM15

Q13444

FLAD1

Q8NFF5

FUNCTION: Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. {ECO:0000269|PubMed:12091380, ECO:0000269|PubMed:15358598, ECO:0000269|PubMed:15818704, ECO:0000269|PubMed:17416588, ECO:0000269|PubMed:17575078, ECO:0000269|PubMed:18387333, ECO:0000269|PubMed:18434311}.FUNCTION: Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. {ECO:0000269|PubMed:16643857, ECO:0000269|PubMed:27259049}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAM15chr1:155029577chr1:154962635ENST00000271836+1121177_184382.6666666666667815.0MotifCysteine switch
HgeneADAM15chr1:155029577chr1:154962635ENST00000355956+1122177_184382.6666666666667840.0MotifCysteine switch
HgeneADAM15chr1:155029577chr1:154962635ENST00000356955+1123177_184382.6666666666667864.0MotifCysteine switch
HgeneADAM15chr1:155029577chr1:154962635ENST00000359280+1122177_184382.6666666666667839.0MotifCysteine switch
HgeneADAM15chr1:155029577chr1:154962635ENST00000360674+1120177_184382.6666666666667812.6666666666666MotifCysteine switch
HgeneADAM15chr1:155029577chr1:154962635ENST00000368412+1121177_184382.6666666666667836.6666666666666MotifCysteine switch
HgeneADAM15chr1:155029577chr1:154962635ENST00000449910+1123177_184382.6666666666667863.0MotifCysteine switch
HgeneADAM15chr1:155029577chr1:154962635ENST00000531455+1121177_184392.6666666666667825.0MotifCysteine switch
TgeneFLAD1chr1:155029577chr1:154962635ENST0000031514438398_555324.6666666666667491.0RegionNote=FAD synthase
TgeneFLAD1chr1:155029577chr1:154962635ENST0000036843103114_2050295.0RegionNote=Molybdenum cofactor biosynthesis protein-like
TgeneFLAD1chr1:155029577chr1:154962635ENST0000036843103398_5550295.0RegionNote=FAD synthase
TgeneFLAD1chr1:155029577chr1:154962635ENST0000036843237398_555324.6666666666667447.0RegionNote=FAD synthase
TgeneFLAD1chr1:155029577chr1:154962635ENST0000040523604398_555273.3333333333333135.66666666666666RegionNote=FAD synthase

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAM15chr1:155029577chr1:154962635ENST00000271836+1121509_656382.6666666666667815.0Compositional biasNote=Cys-rich
HgeneADAM15chr1:155029577chr1:154962635ENST00000355956+1122509_656382.6666666666667840.0Compositional biasNote=Cys-rich
HgeneADAM15chr1:155029577chr1:154962635ENST00000356955+1123509_656382.6666666666667864.0Compositional biasNote=Cys-rich
HgeneADAM15chr1:155029577chr1:154962635ENST00000359280+1122509_656382.6666666666667839.0Compositional biasNote=Cys-rich
HgeneADAM15chr1:155029577chr1:154962635ENST00000360674+1120509_656382.6666666666667812.6666666666666Compositional biasNote=Cys-rich
HgeneADAM15chr1:155029577chr1:154962635ENST00000368412+1121509_656382.6666666666667836.6666666666666Compositional biasNote=Cys-rich
HgeneADAM15chr1:155029577chr1:154962635ENST00000368413+114509_6560521.0Compositional biasNote=Cys-rich
HgeneADAM15chr1:155029577chr1:154962635ENST00000449910+1123509_656382.6666666666667863.0Compositional biasNote=Cys-rich
HgeneADAM15chr1:155029577chr1:154962635ENST00000531455+1121509_656392.6666666666667825.0Compositional biasNote=Cys-rich
HgeneADAM15chr1:155029577chr1:154962635ENST00000271836+1121213_414382.6666666666667815.0DomainPeptidase M12B
HgeneADAM15chr1:155029577chr1:154962635ENST00000271836+1121421_508382.6666666666667815.0DomainDisintegrin
HgeneADAM15chr1:155029577chr1:154962635ENST00000271836+1121657_685382.6666666666667815.0DomainEGF-like
HgeneADAM15chr1:155029577chr1:154962635ENST00000355956+1122213_414382.6666666666667840.0DomainPeptidase M12B
HgeneADAM15chr1:155029577chr1:154962635ENST00000355956+1122421_508382.6666666666667840.0DomainDisintegrin
HgeneADAM15chr1:155029577chr1:154962635ENST00000355956+1122657_685382.6666666666667840.0DomainEGF-like
HgeneADAM15chr1:155029577chr1:154962635ENST00000356955+1123213_414382.6666666666667864.0DomainPeptidase M12B
HgeneADAM15chr1:155029577chr1:154962635ENST00000356955+1123421_508382.6666666666667864.0DomainDisintegrin
HgeneADAM15chr1:155029577chr1:154962635ENST00000356955+1123657_685382.6666666666667864.0DomainEGF-like
HgeneADAM15chr1:155029577chr1:154962635ENST00000359280+1122213_414382.6666666666667839.0DomainPeptidase M12B
HgeneADAM15chr1:155029577chr1:154962635ENST00000359280+1122421_508382.6666666666667839.0DomainDisintegrin
HgeneADAM15chr1:155029577chr1:154962635ENST00000359280+1122657_685382.6666666666667839.0DomainEGF-like
HgeneADAM15chr1:155029577chr1:154962635ENST00000360674+1120213_414382.6666666666667812.6666666666666DomainPeptidase M12B
HgeneADAM15chr1:155029577chr1:154962635ENST00000360674+1120421_508382.6666666666667812.6666666666666DomainDisintegrin
HgeneADAM15chr1:155029577chr1:154962635ENST00000360674+1120657_685382.6666666666667812.6666666666666DomainEGF-like
HgeneADAM15chr1:155029577chr1:154962635ENST00000368412+1121213_414382.6666666666667836.6666666666666DomainPeptidase M12B
HgeneADAM15chr1:155029577chr1:154962635ENST00000368412+1121421_508382.6666666666667836.6666666666666DomainDisintegrin
HgeneADAM15chr1:155029577chr1:154962635ENST00000368412+1121657_685382.6666666666667836.6666666666666DomainEGF-like
HgeneADAM15chr1:155029577chr1:154962635ENST00000368413+114213_4140521.0DomainPeptidase M12B
HgeneADAM15chr1:155029577chr1:154962635ENST00000368413+114421_5080521.0DomainDisintegrin
HgeneADAM15chr1:155029577chr1:154962635ENST00000368413+114657_6850521.0DomainEGF-like
HgeneADAM15chr1:155029577chr1:154962635ENST00000449910+1123213_414382.6666666666667863.0DomainPeptidase M12B
HgeneADAM15chr1:155029577chr1:154962635ENST00000449910+1123421_508382.6666666666667863.0DomainDisintegrin
HgeneADAM15chr1:155029577chr1:154962635ENST00000449910+1123657_685382.6666666666667863.0DomainEGF-like
HgeneADAM15chr1:155029577chr1:154962635ENST00000531455+1121213_414392.6666666666667825.0DomainPeptidase M12B
HgeneADAM15chr1:155029577chr1:154962635ENST00000531455+1121421_508392.6666666666667825.0DomainDisintegrin
HgeneADAM15chr1:155029577chr1:154962635ENST00000531455+1121657_685392.6666666666667825.0DomainEGF-like
HgeneADAM15chr1:155029577chr1:154962635ENST00000271836+1121484_486382.6666666666667815.0MotifCell attachment site
HgeneADAM15chr1:155029577chr1:154962635ENST00000271836+1121815_821382.6666666666667815.0MotifSH3-binding
HgeneADAM15chr1:155029577chr1:154962635ENST00000271836+1121850_856382.6666666666667815.0MotifSH3-binding
HgeneADAM15chr1:155029577chr1:154962635ENST00000355956+1122484_486382.6666666666667840.0MotifCell attachment site
HgeneADAM15chr1:155029577chr1:154962635ENST00000355956+1122815_821382.6666666666667840.0MotifSH3-binding
HgeneADAM15chr1:155029577chr1:154962635ENST00000355956+1122850_856382.6666666666667840.0MotifSH3-binding
HgeneADAM15chr1:155029577chr1:154962635ENST00000356955+1123484_486382.6666666666667864.0MotifCell attachment site
HgeneADAM15chr1:155029577chr1:154962635ENST00000356955+1123815_821382.6666666666667864.0MotifSH3-binding
HgeneADAM15chr1:155029577chr1:154962635ENST00000356955+1123850_856382.6666666666667864.0MotifSH3-binding
HgeneADAM15chr1:155029577chr1:154962635ENST00000359280+1122484_486382.6666666666667839.0MotifCell attachment site
HgeneADAM15chr1:155029577chr1:154962635ENST00000359280+1122815_821382.6666666666667839.0MotifSH3-binding
HgeneADAM15chr1:155029577chr1:154962635ENST00000359280+1122850_856382.6666666666667839.0MotifSH3-binding
HgeneADAM15chr1:155029577chr1:154962635ENST00000360674+1120484_486382.6666666666667812.6666666666666MotifCell attachment site
HgeneADAM15chr1:155029577chr1:154962635ENST00000360674+1120815_821382.6666666666667812.6666666666666MotifSH3-binding
HgeneADAM15chr1:155029577chr1:154962635ENST00000360674+1120850_856382.6666666666667812.6666666666666MotifSH3-binding
HgeneADAM15chr1:155029577chr1:154962635ENST00000368412+1121484_486382.6666666666667836.6666666666666MotifCell attachment site
HgeneADAM15chr1:155029577chr1:154962635ENST00000368412+1121815_821382.6666666666667836.6666666666666MotifSH3-binding
HgeneADAM15chr1:155029577chr1:154962635ENST00000368412+1121850_856382.6666666666667836.6666666666666MotifSH3-binding
HgeneADAM15chr1:155029577chr1:154962635ENST00000368413+114177_1840521.0MotifCysteine switch
HgeneADAM15chr1:155029577chr1:154962635ENST00000368413+114484_4860521.0MotifCell attachment site
HgeneADAM15chr1:155029577chr1:154962635ENST00000368413+114815_8210521.0MotifSH3-binding
HgeneADAM15chr1:155029577chr1:154962635ENST00000368413+114850_8560521.0MotifSH3-binding
HgeneADAM15chr1:155029577chr1:154962635ENST00000449910+1123484_486382.6666666666667863.0MotifCell attachment site
HgeneADAM15chr1:155029577chr1:154962635ENST00000449910+1123815_821382.6666666666667863.0MotifSH3-binding
HgeneADAM15chr1:155029577chr1:154962635ENST00000449910+1123850_856382.6666666666667863.0MotifSH3-binding
HgeneADAM15chr1:155029577chr1:154962635ENST00000531455+1121484_486392.6666666666667825.0MotifCell attachment site
HgeneADAM15chr1:155029577chr1:154962635ENST00000531455+1121815_821392.6666666666667825.0MotifSH3-binding
HgeneADAM15chr1:155029577chr1:154962635ENST00000531455+1121850_856392.6666666666667825.0MotifSH3-binding
HgeneADAM15chr1:155029577chr1:154962635ENST00000271836+1121207_696382.6666666666667815.0Topological domainExtracellular
HgeneADAM15chr1:155029577chr1:154962635ENST00000271836+1121718_863382.6666666666667815.0Topological domainCytoplasmic
HgeneADAM15chr1:155029577chr1:154962635ENST00000355956+1122207_696382.6666666666667840.0Topological domainExtracellular
HgeneADAM15chr1:155029577chr1:154962635ENST00000355956+1122718_863382.6666666666667840.0Topological domainCytoplasmic
HgeneADAM15chr1:155029577chr1:154962635ENST00000356955+1123207_696382.6666666666667864.0Topological domainExtracellular
HgeneADAM15chr1:155029577chr1:154962635ENST00000356955+1123718_863382.6666666666667864.0Topological domainCytoplasmic
HgeneADAM15chr1:155029577chr1:154962635ENST00000359280+1122207_696382.6666666666667839.0Topological domainExtracellular
HgeneADAM15chr1:155029577chr1:154962635ENST00000359280+1122718_863382.6666666666667839.0Topological domainCytoplasmic
HgeneADAM15chr1:155029577chr1:154962635ENST00000360674+1120207_696382.6666666666667812.6666666666666Topological domainExtracellular
HgeneADAM15chr1:155029577chr1:154962635ENST00000360674+1120718_863382.6666666666667812.6666666666666Topological domainCytoplasmic
HgeneADAM15chr1:155029577chr1:154962635ENST00000368412+1121207_696382.6666666666667836.6666666666666Topological domainExtracellular
HgeneADAM15chr1:155029577chr1:154962635ENST00000368412+1121718_863382.6666666666667836.6666666666666Topological domainCytoplasmic
HgeneADAM15chr1:155029577chr1:154962635ENST00000368413+114207_6960521.0Topological domainExtracellular
HgeneADAM15chr1:155029577chr1:154962635ENST00000368413+114718_8630521.0Topological domainCytoplasmic
HgeneADAM15chr1:155029577chr1:154962635ENST00000449910+1123207_696382.6666666666667863.0Topological domainExtracellular
HgeneADAM15chr1:155029577chr1:154962635ENST00000449910+1123718_863382.6666666666667863.0Topological domainCytoplasmic
HgeneADAM15chr1:155029577chr1:154962635ENST00000531455+1121207_696392.6666666666667825.0Topological domainExtracellular
HgeneADAM15chr1:155029577chr1:154962635ENST00000531455+1121718_863392.6666666666667825.0Topological domainCytoplasmic
HgeneADAM15chr1:155029577chr1:154962635ENST00000271836+1121697_717382.6666666666667815.0TransmembraneHelical
HgeneADAM15chr1:155029577chr1:154962635ENST00000355956+1122697_717382.6666666666667840.0TransmembraneHelical
HgeneADAM15chr1:155029577chr1:154962635ENST00000356955+1123697_717382.6666666666667864.0TransmembraneHelical
HgeneADAM15chr1:155029577chr1:154962635ENST00000359280+1122697_717382.6666666666667839.0TransmembraneHelical
HgeneADAM15chr1:155029577chr1:154962635ENST00000360674+1120697_717382.6666666666667812.6666666666666TransmembraneHelical
HgeneADAM15chr1:155029577chr1:154962635ENST00000368412+1121697_717382.6666666666667836.6666666666666TransmembraneHelical
HgeneADAM15chr1:155029577chr1:154962635ENST00000368413+114697_7170521.0TransmembraneHelical
HgeneADAM15chr1:155029577chr1:154962635ENST00000449910+1123697_717382.6666666666667863.0TransmembraneHelical
HgeneADAM15chr1:155029577chr1:154962635ENST00000531455+1121697_717392.6666666666667825.0TransmembraneHelical
TgeneFLAD1chr1:155029577chr1:154962635ENST0000029218027114_205421.6666666666667588.0RegionNote=Molybdenum cofactor biosynthesis protein-like
TgeneFLAD1chr1:155029577chr1:154962635ENST0000029218027398_555421.6666666666667588.0RegionNote=FAD synthase
TgeneFLAD1chr1:155029577chr1:154962635ENST0000031514438114_205324.6666666666667491.0RegionNote=Molybdenum cofactor biosynthesis protein-like
TgeneFLAD1chr1:155029577chr1:154962635ENST0000036843237114_205324.6666666666667447.0RegionNote=Molybdenum cofactor biosynthesis protein-like
TgeneFLAD1chr1:155029577chr1:154962635ENST0000040523604114_205273.3333333333333135.66666666666666RegionNote=Molybdenum cofactor biosynthesis protein-like


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Fusion Gene Sequence for ADAM15-FLAD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ADAM15-FLAD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADAM15-FLAD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ADAM15-FLAD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFLAD1C4310822LIPID STORAGE MYOPATHY DUE TO FLAVIN ADENINE DINUCLEOTIDE SYNTHETASE DEFICIENCY4CLINGEN;GENOMICS_ENGLAND;UNIPROT