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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CYB5R4-FNDC1 (FusionGDB2 ID:20934)

Fusion Gene Summary for CYB5R4-FNDC1

check button Fusion gene summary
Fusion gene informationFusion gene name: CYB5R4-FNDC1
Fusion gene ID: 20934
HgeneTgene
Gene symbol

CYB5R4

FNDC1

Gene ID

51167

84624

Gene namecytochrome b5 reductase 4fibronectin type III domain containing 1
SynonymsNCB5OR|cb5/cb5R|dJ676J13.1AGS8|FNDC2|MEL4B3|bA243O10.1|dJ322A24.1
Cytomap

6q14.2

6q25.3

Type of geneprotein-codingprotein-coding
Descriptioncytochrome b5 reductase 4N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing proteinNADPH cytochrome B5 oxidoreductasecytochrome b-type NAD(P)H oxidoreductaseflavohemoprotein b5+b5Rflavohemoprotein b5/b5Rfibronectin type III domain-containing protein 1activation-associated cDNA proteinexpressed in synovial lining proteinfibronectin type III domain containing 2
Modification date2020031320200313
UniProtAcc

Q7L1T6

Q4ZHG4

Ensembl transtripts involved in fusion geneENST00000369681, ENST00000369679, 
ENST00000479164, 		ENST00000340366, 
ENST00000297267, ENST00000480856, 
Fusion gene scores* DoF score4 X 1 X 4=164 X 3 X 4=48
# samples 44
** MAII scorelog2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CYB5R4 [Title/Abstract] AND FNDC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCYB5R4(84574047)-FNDC1(159618463), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCYB5R4

GO:0006091

generation of precursor metabolites and energy

10611283

HgeneCYB5R4

GO:0006801

superoxide metabolic process

10611283

HgeneCYB5R4

GO:0055114

oxidation-reduction process

15131110


check buttonFusion gene breakpoints across CYB5R4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FNDC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-YL-A8SP-01BCYB5R4chr6

84574047

+FNDC1chr6

159618463

+
ChimerDB4PRADTCGA-YL-A8SP-01BCYB5R4chr6

84574047

-FNDC1chr6

159618463

+


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Fusion Gene ORF analysis for CYB5R4-FNDC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000369681ENST00000340366CYB5R4chr6

84574047

+FNDC1chr6

159618463

+
In-frameENST00000369681ENST00000297267CYB5R4chr6

84574047

+FNDC1chr6

159618463

+
5CDS-intronENST00000369681ENST00000480856CYB5R4chr6

84574047

+FNDC1chr6

159618463

+
In-frameENST00000369679ENST00000340366CYB5R4chr6

84574047

+FNDC1chr6

159618463

+
In-frameENST00000369679ENST00000297267CYB5R4chr6

84574047

+FNDC1chr6

159618463

+
5CDS-intronENST00000369679ENST00000480856CYB5R4chr6

84574047

+FNDC1chr6

159618463

+
intron-3CDSENST00000479164ENST00000340366CYB5R4chr6

84574047

+FNDC1chr6

159618463

+
intron-3CDSENST00000479164ENST00000297267CYB5R4chr6

84574047

+FNDC1chr6

159618463

+
intron-intronENST00000479164ENST00000480856CYB5R4chr6

84574047

+FNDC1chr6

159618463

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000369681CYB5R4chr684574047+ENST00000340366FNDC1chr6159618463+64193695057551901
ENST00000369681CYB5R4chr684574047+ENST00000297267FNDC1chr6159618463+66123695059441964
ENST00000369679CYB5R4chr684574047+ENST00000340366FNDC1chr6159618463+64063563757421901
ENST00000369679CYB5R4chr684574047+ENST00000297267FNDC1chr6159618463+65993563759311964

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000369681ENST00000340366CYB5R4chr684574047+FNDC1chr6159618463+0.0007505010.9992495
ENST00000369681ENST00000297267CYB5R4chr684574047+FNDC1chr6159618463+0.00075390.9992461
ENST00000369679ENST00000340366CYB5R4chr684574047+FNDC1chr6159618463+0.0007294850.9992705
ENST00000369679ENST00000297267CYB5R4chr684574047+FNDC1chr6159618463+0.0007336110.99926645

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Fusion Genomic Features for CYB5R4-FNDC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CYB5R4chr684574047+FNDC1chr6159618462+0.0012882290.9987118
CYB5R4chr684574047+FNDC1chr6159618462+0.0012882290.9987118

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CYB5R4-FNDC1


check button Go to

FGviewer for the breakpoints of chr6:84574047-chr6:159618463

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CYB5R4

Q7L1T6

FNDC1

Q4ZHG4

FUNCTION: NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.FUNCTION: May be an activator of G protein signaling. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFNDC1chr6:84574047chr6:159618463ENST000002972670231443_151636.3333333333333361895.0Compositional biasNote=Thr-rich
TgeneFNDC1chr6:84574047chr6:159618463ENST00000297267023671_77336.3333333333333361895.0Compositional biasNote=Ser-rich
TgeneFNDC1chr6:84574047chr6:159618463ENST000003403660221443_151636.3333333333333361832.0Compositional biasNote=Thr-rich
TgeneFNDC1chr6:84574047chr6:159618463ENST00000340366022671_77336.3333333333333361832.0Compositional biasNote=Ser-rich
TgeneFNDC1chr6:84574047chr6:159618463ENST00000297267023158_25836.3333333333333361895.0DomainFibronectin type-III 2
TgeneFNDC1chr6:84574047chr6:159618463ENST000002972670231658_175236.3333333333333361895.0DomainFibronectin type-III 5
TgeneFNDC1chr6:84574047chr6:159618463ENST00000297267023262_35736.3333333333333361895.0DomainFibronectin type-III 3
TgeneFNDC1chr6:84574047chr6:159618463ENST00000297267023362_45736.3333333333333361895.0DomainFibronectin type-III 4
TgeneFNDC1chr6:84574047chr6:159618463ENST0000029726702339_13136.3333333333333361895.0DomainFibronectin type-III 1
TgeneFNDC1chr6:84574047chr6:159618463ENST00000340366022158_25836.3333333333333361832.0DomainFibronectin type-III 2
TgeneFNDC1chr6:84574047chr6:159618463ENST000003403660221658_175236.3333333333333361832.0DomainFibronectin type-III 5
TgeneFNDC1chr6:84574047chr6:159618463ENST00000340366022262_35736.3333333333333361832.0DomainFibronectin type-III 3
TgeneFNDC1chr6:84574047chr6:159618463ENST00000340366022362_45736.3333333333333361832.0DomainFibronectin type-III 4
TgeneFNDC1chr6:84574047chr6:159618463ENST0000034036602239_13136.3333333333333361832.0DomainFibronectin type-III 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCYB5R4chr6:84574047chr6:159618463ENST00000369681+216165_25676.33333333333333522.0DomainCS
HgeneCYB5R4chr6:84574047chr6:159618463ENST00000369681+216273_38576.33333333333333522.0DomainFAD-binding FR-type
HgeneCYB5R4chr6:84574047chr6:159618463ENST00000369681+21654_13076.33333333333333522.0DomainCytochrome b5 heme-binding
HgeneCYB5R4chr6:84574047chr6:159618463ENST00000369681+216365_38076.33333333333333522.0Nucleotide bindingFAD
HgeneCYB5R4chr6:84574047chr6:159618463ENST00000369681+216392_42476.33333333333333522.0Nucleotide bindingFAD


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Fusion Gene Sequence for CYB5R4-FNDC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000369681_ENST00000340366_TCGA-YL-A8SP-01B_CYB5R4_chr6_84574047_+_FNDC1_chr6_159618463_length(transcript)=6419nt_BP=369nt
TGCGTCAGAATGCGCCTCACCCCTGGCGACCCCGGAAGTGGGTCGGGGGCTTGGCCTCTGCCCGGCCACAGAGCCGGAGCTGGAGGTGCT
GTCCCGTCTGGCGGCGATCCCCGGGCAGGGCCCGGGGCCGGGGTTTGAAGATGCTGAACGTCCCTTCCCAGTCTTTCCCGGCCCCCAGGT
CGCAGCAGCGTGTCGCCTCCGGGGGGCGTAGCAAGGTACCTTTAAAACAGGGCAGAAGCCTTATGGATTGGATTCGACTGACCAAAAGTG
GAAAGGATCTAACGGGATTAAAAGGCAGGTTAATTGAAGTAACTGAAGAAGAACTTAAGAAACACAACAAAAAAGATGATTGTTGGATAT
GCATAAGAGTTGACCACCCACTGAAGCCAAGGCATGTGAAACTGCTGTCCACTAAAATGGGCCTGAAAGTCACGTGGGACCCACCCAAAG
ATGCTACCAGTAGACCTGTGGAGCATTACAACATTGCCTATGGGAAGTCACTGAAAAGTCTTAAATACATCAAGGTGAATGCGGAGACAT
ACTCCTTCCTTATTGAGGATGTGGAGCCGGGGGTAGTGTACTTTGTGCTGCTTACTGCAGAAAACCACAGTGGAGTGAGCCGTCCTGTTT
ACAGAGCTGAAAGCCCACCTGGAGGTGAATGGATCGAGATTGATGGTTTTCCCATTAAGGGTCCAGGACCATTTAATGAAACCGTCACAG
AAAAGGAAGTGCCCAACAAGCCCTTGCGTGTGCGTGTCCGGTCCTCAGATGACAGGCTGTCCGTTGCGTGGAAGGCACCACGCCTGTCTG
GAGCCAAGAGTCCACGCAGATCACGGGGTTTTCTCCTGGGCTACGGGGAGAGTGGCCGGAAGATGAATTATGTTCCACTGACAAGAGATG
AACGGACACACGAAATTAAAAAGCTAGCCTCGGAATCCGTGTATGTGGTCTCCCTGCAGTCCATGAACTCTCAGGGCCGGAGCCAACCAG
TCTACAGGGCTGCCCTAACAAAGCGAAAGATTTCAGAAGAGGACGAATTGGATGTACCTGACGACATCAGCGTCCGGGTTATGTCATCTC
AGTCTGTGCTTGTGTCCTGGGTGGATCCTGTTCTGGAAAAACAGAAGAAAGTTGTTGCATCAAGACAGTACACCGTGCGCTATCGAGAGA
AGGGGGAATTGGCCAGGTGGGATTATAAGCAGATCGCTAACAGGCGTGTGCTGATTGAGAACCTGATTCCAGACACTGTGTATGAATTTG
CAGTCCGTATTTCACAGGGTGAAAGAGATGGCAAATGGAGTACGTCAGTCTTCCAAAGAACACCAGAATCTGCCCCTACCACAGCTCCTG
AAAACTTGAACGTCTGGCCAGTCAATGGCAAACCTACAGTTGTCGCTGCATCTTGGGATGCGCTACCAGAGACTGAGGGGAAAGTGAAAG
CCAGTAAGGCGGATGTTGAGCAGAACACGGAGGACAATGGGAAACCCGAAAAACCTGAGCCTTCCTCACCTTCTCCCAGAGCTCCAGCTT
CCTCCCAACACCCCTCTGTGCCTGCTTCTCCCCAAGGGAGAAATGCCAAGGACCTTCTTCTTGACTTGAAGAACAAAATATTGGCTAATG
GTGGGGCGCCCCGAAAACCCCAGCTTCGCGCCAAGAAGGCAGAGGAGCTGGATCTTCAGTCGACAGAAATCACTGGGGAGGAGGAGCTGG
GTTCCCGGGAGGACTCGCCCATGTCACCCTCAGACACCCAAGACCAGAAACGGACCCTGAGGCCGCCAAGTAGACACGGCCACTCGGTGG
TTGCTCCCGGCAGGACTGCAGTGAGGGCCCGGATGCCAGCGCTGCCCCGAAGGGAAGGCGTAGATAAGCCTGGCTTTTCCCTGGCCACGC
AGCCCCGCCCAGGGGCGCCCCCCTCGGCTTCGGCCTCTCCTGCCCACCACGCGTCCACCCAGGGCACCTCTCATCGTCCTTCCCTGCCTG
CCAGCTTGAATGACAACGACTTGGTGGACTCAGACGAAGATGAGCGCGCTGTGGGCTCCCTCCACCCCAAGGGCGCCTTCGCCCAGCCCC
GGCCAGCCCTGTCCCCCAGCCGCCAGTCCCCGTCCAGCGTTCTCCGCGACAGAAGCTCTGTGCACCCCGGCGCAAAGCCAGCCTCGCCGG
CCCGGAGGACCCCCCATTCAGGGGCCGCAGAGGAAGATTCCAGTGCCTCAGCCCCACCCTCAAGACTTTCTCCACCCCATGGGGGATCAT
CTCGGCTGCTGCCCACCCAGCCACACCTGAGCTCTCCACTTTCCAAGGGCGGGAAGGATGGTGAGGACGCCCCAGCCACCAACTCCAATG
CGCCATCACGGTCCACCATGTCCTCCTCCGTCTCTTCTCATCTCTCGTCCAGGACGCAGGTCTCTGAGGGAGCGGAGGCTTCTGATGGTG
AAAGCCACGGTGACGGCGATAGGGAAGACGGCGGAAGGCAGGCGGAGGCCACGGCCCAGACGCTGCGGGCCCGGCCTGCCTCTGGACACT
TCCATTTGCTCAGACACAAACCCTTTGCTGCCAACGGGAGGTCTCCAAGCAGGTTCAGCATTGGGCGGGGACCTCGGCTGCAGCCCTCCA
GCTCCCCACAGTCGACTGTGCCCTCCCGAGCCCACCCCAGGGTTCCCTCTCACTCTGATTCCCACCCTAAGCTTAGCTCAGGTATCCATG
GAGACGAGGAGGATGAGAAGCCGCTTCCTGCCACCGTTGTCAATGACCACGTGCCTTCCTCCTCCAGGCAGCCCATCTCCCGGGGCTGGG
AGGACTTAAGGAGAAGCCCGCAGAGAGGGGCCAGCCTGCATCGGAAGGAACCCATCCCAGAGAACCCCAAATCCACAGGGGCAGATACAC
ATCCTCAGGGCAAGTACTCCTCCCTGGCCTCCAAGGCTCAGGATGTTCAACAGAGCACAGACGCGGACACGGAGGGTCATTCTCCCAAAG
CACAGCCAGGGTCCACAGACCGCCACGCGTCCCCTGCTCGTCCGCCCGCAGCACGGTCACAGCAGCATCCCAGTGTTCCCAGAAGGATGA
CACCCGGCCGGGCCCCACAACAGCAGCCCCCTCCTCCCGTCGCCACGTCCCAGCACCACCCGGGACCCCAGAGCAGAGACGCGGGTCGGT
CACCTTCCCAGCCCAGGCTCTCACTGACCCAGGCCGGGCGGCCCCGCCCCACGTCGCAGGGCCGCTCCCACTCCTCCTCGGACCCTTACA
CGGCGAGCTCCAGAGGGATGCTCCCCACGGCCCTCCAGAACCAGGACGAGGATGCCCAGGGCAGCTACGACGACGACAGCACAGAAGTCG
AGGCCCAGGATGTGCGGGCCCCCGCGCACGCCGCGCGCGCCAAGGAGGCAGCTGCGTCCCTTCCCAAGCACCAGCAGGTGGAGTCTCCCA
CAGGCGCAGGGGCAGGTGGCGACCACAGGTCCCAGCGCGGACATGCGGCCTCCCCCGCCAGGCCCAGCCGACCCGGCGGCCCCCAGTCCC
GCGCCCGGGTACCCAGCAGGGCAGCGCCGGGGAAGTCGGAGCCTCCTTCCAAGCGGCCCCTGTCCTCCAAGTCCCAGCAGTCGGTCTCAG
CCGAGGACGACGAGGAGGAGGACGCGGGATTTTTTAAAGGCGGGAAAGAAGACCTTCTGTCTTCCTCTGTGCCAAAGTGGCCCTCTTCCT
CCACTCCCAGGGGCGGCAAAGACGCCGATGGGAGCCTCGCCAAGGAAGAGAGGGAGCCTGCCATCGCGCTTGCCCCTCGCGGAGGGAGCC
TGGCTCCTGTGAAGCGACCTCTCCCCCCACCTCCAGGCAGCTCCCCCAGGGCCTCCCACGTCCCTTCCCGACTGCCGCCTCGCAGCGCTG
CCACCGTGAGCCCCGTCGCGGGCACCCACCCCTGGCCGCAGTACACCACGCGCGCCCCACCTGGCCACTTCTCCACCACCCCGATGCTGT
CCTTGCGCCAGAGGATGATGCATGCCAGATTCCGTAACCCTCTCTCCCGACAGCCTGCCAGACCCTCTTACAGACAAGGTTATAATGGCA
GACCAAATGTAGAAGGGAAAGTCCTTCCTGGTAGTAATGGAAAACCGAATGGACAGAGAATTATCAATGGCCCTCAAGGAACAAAGTGGG
TTGTGGACCTTGATCGTGGGTTAGTATTGAATGCAGAAGGAAGGTACCTCCAAGATTCACATGGAAATCCTCTTCGGATTAAACTAGGAG
GAGATGGTCGAACCATTGTAGATCTGGAAGGGACCCCCGTGGTGAGTCCTGACGGCCTCCCACTCTTTGGGCAGGGGCGACATGGCACAC
CTCTGGCCAATGCCCAAGATAAGCCAATTTTGAGTCTTGGAGGAAAGCCGCTGGTGGGCTTGGAGGTCATCAAAAAAACCACCCATCCCC
CTACCACTACCATGCAGCCCACCACTACTACGACGCCCCTGCCTACCACTACAACCCCGAGGCCCACCACTGCCACCACCCGCCGCACGA
CCACCACCCGCCGCACGACCACCAGGCGTCCAACAACCACAGTCCGAACCACTACGCGGACAACCACCACCACCACCCCCACACCCACCA
CTCCCATCCCCACCTGTCCCCCTGGGACCTTGGAACGGCACGACGATGATGGCAACCTGATAATGAGCTCCAATGGGATCCCAGAGTGCT
ACGCTGAAGAAGATGAGTTCTCAGGCTTGGAGACTGACACTGCAGTACCTACGGAAGAGGCCTACGTTATATATGATGAAGATTATGAAT
TTGAGACGTCAAGGCCACCAACCACCACTGAGCCTTCGACCACTGCTACCACACCGAGGGTGATCCCAGAGGAAGGCGCCATCAGTTCCT
TTCCTGAAGAAGAATTTGATCTGGCTGGAAGGAAACGATTTGTTGCTCCTTACGTGACGTACCTAAATAAAGACCCATCAGCCCCGTGCT
CTCTGACTGATGCACTGGATCACTTCCAAGTGGACAGCCTGGATGAAATCATCCCCAATGACCTGAAGAAGAGTGACCTGCCTCCCCAGC
ATGCTCCCCGCAACATCACCGTGGTGGCCGTGGAAGGTTGCCACTCATTTGTCATTGTGGACTGGGACAAAGCCACCCCAGGAGATGTGG
TCACAGGTTACTTGGTTTACAGTGCATCCTATGAAGACTTCATCAGGAACAAGTGGTCCACTCAAGCTTCATCAGTAACTCACTTGCCCA
TTGAGAACCTAAAGCCCAACACGAGGTATTATTTTAAAGTGCAAGCACAAAATCCTCATGGCTACGGACCTATCAGCCCTTCGGTCTCAT
TTGTCACCGAATCAGATAATCCTCTGCTTGTTGTGAGGCCCCCAGGCGGTGAGCCTATCTGGATCCCATTCGCTTTCAAACATGATCCCA
GCTACACGGACTGCCATGGACGGCAATATGTGAAGCGCACGTGGTATCGAAAGTTCGTGGGAGTTGTTCTTTGTAATTCACTGAGGTATA
AAATCTACCTCAGTGACAACCTGAAAGATACATTCTACAGCATTGGAGACAGCTGGGGAAGAGGTGAAGACCATTGCCAATTTGTGGATT
CACACCTTGATGGAAGAACAGGGCCTCAGTCCTATGTAGAAGCCCTCCCTACTATTCAAGGCTACTATCGCCAGTATCGTCAGGAGCCTG
TCAGGTTTGGGAACATCGGCTTCGGAACCCCCTACTACTATGTGGGCTGGTACGAGTGTGGGGTCTCCATCCCTGGAAAGTGGTAATCAC
AGGACCGTCATGCTGCAAGCTTGCCCTGCCCAGCCCCACCAACTAAGTCGCACTAGGGGCTGTGAGCAAAGACAGCCAGCGTGCTCAGCC
CCGCTGCCCTAGGTGCCAGGAAGGTCATAGATGGACACTGGCCATTCTGGTCATCTCAGTCTGGAACTCAGTCCCACTTCTTGGCCTGGA
CAATGAACAGGATTCAGTTTTGCTGTTAACTTTGCTTCTCTACTTTTTTTTGTTTGTTTGTAATAGCACATCCCAGAGACATCAGAAACC
AGCAACTGATTCAGTGTGATTTCCAGACTTTTTAGGCATGAAATTCGGACACTTCAGTATTTCCAGGAATAGCATATGCACGCTGTTCTT
GCTTCATGGAATGCTACATGCTTTCTGTTTTTCTCATTTTGGATTTCTCCAAAACTAACTGAATTTAAGCTTCAGGTCCCTTTGTATGCA
GTAGAAAGGAATTATTAAAAACACCACCAAAGAAAATAAATATATCCTACTTGAAATTTACTCTATGGACTTACCCACTGCTAGAATAAA
TGTATCAAATCTTATTTGTAAATTCTCAATTTTGATATATATATGTATATATGCATATACATATCCACACTTGTCTGCAAGAATATTGAT

>In-frame_ENST00000369681_ENST00000340366_TCGA-YL-A8SP-01B_CYB5R4_chr6_84574047_+_FNDC1_chr6_159618463_length(amino acids)=1901AA_start in transcript=50_stop in transcript=5755
MASARPQSRSWRCCPVWRRSPGRARGRGLKMLNVPSQSFPAPRSQQRVASGGRSKVPLKQGRSLMDWIRLTKSGKDLTGLKGRLIEVTEE
ELKKHNKKDDCWICIRVDHPLKPRHVKLLSTKMGLKVTWDPPKDATSRPVEHYNIAYGKSLKSLKYIKVNAETYSFLIEDVEPGVVYFVL
LTAENHSGVSRPVYRAESPPGGEWIEIDGFPIKGPGPFNETVTEKEVPNKPLRVRVRSSDDRLSVAWKAPRLSGAKSPRRSRGFLLGYGE
SGRKMNYVPLTRDERTHEIKKLASESVYVVSLQSMNSQGRSQPVYRAALTKRKISEEDELDVPDDISVRVMSSQSVLVSWVDPVLEKQKK
VVASRQYTVRYREKGELARWDYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAA
SWDALPETEGKVKASKADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEEL
DLQSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHH
ASTQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSAS
APPSRLSPPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEA
TAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDH
VPSSSRQPISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPA
ARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDE
DAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPPS
KRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPR
ASHVPSRLPPRSAATVSPVAGTHPWPQYTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSYRQGYNGRPNVEGKVLPGSNGKPN
GQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKP
LVGLEVIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTPTTPIPTCPPGTLERHDDD
GNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIPEEGAISSFPEEEFDLAGRKRFVAP
YVTYLNKDPSAPCSLTDALDHFQVDSLDEIIPNDLKKSDLPPQHAPRNITVVAVEGCHSFVIVDWDKATPGDVVTGYLVYSASYEDFIRN
KWSTQASSVTHLPIENLKPNTRYYFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRPPGGEPIWIPFAFKHDPSYTDCHGRQYVKRTWYR
KFVGVVLCNSLRYKIYLSDNLKDTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVRFGNIGFGTPYYYVGW

--------------------------------------------------------------
>In-frame_ENST00000369681_ENST00000297267_TCGA-YL-A8SP-01B_CYB5R4_chr6_84574047_+_FNDC1_chr6_159618463_length(transcript)=6612nt_BP=369nt
TGCGTCAGAATGCGCCTCACCCCTGGCGACCCCGGAAGTGGGTCGGGGGCTTGGCCTCTGCCCGGCCACAGAGCCGGAGCTGGAGGTGCT
GTCCCGTCTGGCGGCGATCCCCGGGCAGGGCCCGGGGCCGGGGTTTGAAGATGCTGAACGTCCCTTCCCAGTCTTTCCCGGCCCCCAGGT
CGCAGCAGCGTGTCGCCTCCGGGGGGCGTAGCAAGGTACCTTTAAAACAGGGCAGAAGCCTTATGGATTGGATTCGACTGACCAAAAGTG
GAAAGGATCTAACGGGATTAAAAGGCAGGTTAATTGAAGTAACTGAAGAAGAACTTAAGAAACACAACAAAAAAGATGATTGTTGGATAT
GCATAAGAGTTGACCACCCACTGAAGCCAAGGCATGTGAAACTGCTGTCCACTAAAATGGGCCTGAAAGTCACGTGGGACCCACCCAAAG
ATGCTACCAGTAGACCTGTGGAGCATTACAACATTGCCTATGGGAAGTCACTGAAAAGTCTTAAATACATCAAGGTGAATGCGGAGACAT
ACTCCTTCCTTATTGAGGATGTGGAGCCGGGGGTAGTGTACTTTGTGCTGCTTACTGCAGAAAACCACAGTGGAGTGAGCCGTCCTGTTT
ACAGAGCTGAAAGCCCACCTGGAGGTGAATGGATCGAGATTGATGGTTTTCCCATTAAGGGTCCAGGACCATTTAATGAAACCGTCACAG
AAAAGGAAGTGCCCAACAAGCCCTTGCGTGTGCGTGTCCGGTCCTCAGATGACAGGCTGTCCGTTGCGTGGAAGGCACCACGCCTGTCTG
GAGCCAAGAGTCCACGCAGATCACGGGGTTTTCTCCTGGGCTACGGGGAGAGTGGCCGGAAGATGAATTATGTTCCACTGACAAGAGATG
AACGGACACACGAAATTAAAAAGCTAGCCTCGGAATCCGTGTATGTGGTCTCCCTGCAGTCCATGAACTCTCAGGGCCGGAGCCAACCAG
TCTACAGGGCTGCCCTAACAAAGCGAAAGATTTCAGAAGAGGACGAATTGGATGTACCTGACGACATCAGCGTCCGGGTTATGTCATCTC
AGTCTGTGCTTGTGTCCTGGGTGGATCCTGTTCTGGAAAAACAGAAGAAAGTTGTTGCATCAAGACAGTACACCGTGCGCTATCGAGAGA
AGGGGGAATTGGCCAGGTGGGATTATAAGCAGATCGCTAACAGGCGTGTGCTGATTGAGAACCTGATTCCAGACACTGTGTATGAATTTG
CAGTCCGTATTTCACAGGGTGAAAGAGATGGCAAATGGAGTACGTCAGTCTTCCAAAGAACACCAGAATCTGCCCCTACCACAGCTCCTG
AAAACTTGAACGTCTGGCCAGTCAATGGCAAACCTACAGTTGTCGCTGCATCTTGGGATGCGCTACCAGAGACTGAGGGGAAAGTGAAAG
AATACATTCTTTCATACGCCCCGGCTCTCAAACCATTTGGAGCAAAGTCCCTCACCTATCCTGGAGACACTACTTCTGCCCTGGTGGATG
GTCTGCAGCCTGGGGAACGCTATCTTTTCAAAATCCGGGCCACAAACAGGAGAGGCCTGGGACCTCACTCCAAAGCCTTCATTGTCGCTA
TGCCAACAACCAGTAAGGCGGATGTTGAGCAGAACACGGAGGACAATGGGAAACCCGAAAAACCTGAGCCTTCCTCACCTTCTCCCAGAG
CTCCAGCTTCCTCCCAACACCCCTCTGTGCCTGCTTCTCCCCAAGGGAGAAATGCCAAGGACCTTCTTCTTGACTTGAAGAACAAAATAT
TGGCTAATGGTGGGGCGCCCCGAAAACCCCAGCTTCGCGCCAAGAAGGCAGAGGAGCTGGATCTTCAGTCGACAGAAATCACTGGGGAGG
AGGAGCTGGGTTCCCGGGAGGACTCGCCCATGTCACCCTCAGACACCCAAGACCAGAAACGGACCCTGAGGCCGCCAAGTAGACACGGCC
ACTCGGTGGTTGCTCCCGGCAGGACTGCAGTGAGGGCCCGGATGCCAGCGCTGCCCCGAAGGGAAGGCGTAGATAAGCCTGGCTTTTCCC
TGGCCACGCAGCCCCGCCCAGGGGCGCCCCCCTCGGCTTCGGCCTCTCCTGCCCACCACGCGTCCACCCAGGGCACCTCTCATCGTCCTT
CCCTGCCTGCCAGCTTGAATGACAACGACTTGGTGGACTCAGACGAAGATGAGCGCGCTGTGGGCTCCCTCCACCCCAAGGGCGCCTTCG
CCCAGCCCCGGCCAGCCCTGTCCCCCAGCCGCCAGTCCCCGTCCAGCGTTCTCCGCGACAGAAGCTCTGTGCACCCCGGCGCAAAGCCAG
CCTCGCCGGCCCGGAGGACCCCCCATTCAGGGGCCGCAGAGGAAGATTCCAGTGCCTCAGCCCCACCCTCAAGACTTTCTCCACCCCATG
GGGGATCATCTCGGCTGCTGCCCACCCAGCCACACCTGAGCTCTCCACTTTCCAAGGGCGGGAAGGATGGTGAGGACGCCCCAGCCACCA
ACTCCAATGCGCCATCACGGTCCACCATGTCCTCCTCCGTCTCTTCTCATCTCTCGTCCAGGACGCAGGTCTCTGAGGGAGCGGAGGCTT
CTGATGGTGAAAGCCACGGTGACGGCGATAGGGAAGACGGCGGAAGGCAGGCGGAGGCCACGGCCCAGACGCTGCGGGCCCGGCCTGCCT
CTGGACACTTCCATTTGCTCAGACACAAACCCTTTGCTGCCAACGGGAGGTCTCCAAGCAGGTTCAGCATTGGGCGGGGACCTCGGCTGC
AGCCCTCCAGCTCCCCACAGTCGACTGTGCCCTCCCGAGCCCACCCCAGGGTTCCCTCTCACTCTGATTCCCACCCTAAGCTTAGCTCAG
GTATCCATGGAGACGAGGAGGATGAGAAGCCGCTTCCTGCCACCGTTGTCAATGACCACGTGCCTTCCTCCTCCAGGCAGCCCATCTCCC
GGGGCTGGGAGGACTTAAGGAGAAGCCCGCAGAGAGGGGCCAGCCTGCATCGGAAGGAACCCATCCCAGAGAACCCCAAATCCACAGGGG
CAGATACACATCCTCAGGGCAAGTACTCCTCCCTGGCCTCCAAGGCTCAGGATGTTCAACAGAGCACAGACGCGGACACGGAGGGTCATT
CTCCCAAAGCACAGCCAGGGTCCACAGACCGCCACGCGTCCCCTGCTCGTCCGCCCGCAGCACGGTCACAGCAGCATCCCAGTGTTCCCA
GAAGGATGACACCCGGCCGGGCCCCACAACAGCAGCCCCCTCCTCCCGTCGCCACGTCCCAGCACCACCCGGGACCCCAGAGCAGAGACG
CGGGTCGGTCACCTTCCCAGCCCAGGCTCTCACTGACCCAGGCCGGGCGGCCCCGCCCCACGTCGCAGGGCCGCTCCCACTCCTCCTCGG
ACCCTTACACGGCGAGCTCCAGAGGGATGCTCCCCACGGCCCTCCAGAACCAGGACGAGGATGCCCAGGGCAGCTACGACGACGACAGCA
CAGAAGTCGAGGCCCAGGATGTGCGGGCCCCCGCGCACGCCGCGCGCGCCAAGGAGGCAGCTGCGTCCCTTCCCAAGCACCAGCAGGTGG
AGTCTCCCACAGGCGCAGGGGCAGGTGGCGACCACAGGTCCCAGCGCGGACATGCGGCCTCCCCCGCCAGGCCCAGCCGACCCGGCGGCC
CCCAGTCCCGCGCCCGGGTACCCAGCAGGGCAGCGCCGGGGAAGTCGGAGCCTCCTTCCAAGCGGCCCCTGTCCTCCAAGTCCCAGCAGT
CGGTCTCAGCCGAGGACGACGAGGAGGAGGACGCGGGATTTTTTAAAGGCGGGAAAGAAGACCTTCTGTCTTCCTCTGTGCCAAAGTGGC
CCTCTTCCTCCACTCCCAGGGGCGGCAAAGACGCCGATGGGAGCCTCGCCAAGGAAGAGAGGGAGCCTGCCATCGCGCTTGCCCCTCGCG
GAGGGAGCCTGGCTCCTGTGAAGCGACCTCTCCCCCCACCTCCAGGCAGCTCCCCCAGGGCCTCCCACGTCCCTTCCCGACTGCCGCCTC
GCAGCGCTGCCACCGTGAGCCCCGTCGCGGGCACCCACCCCTGGCCGCAGTACACCACGCGCGCCCCACCTGGCCACTTCTCCACCACCC
CGATGCTGTCCTTGCGCCAGAGGATGATGCATGCCAGATTCCGTAACCCTCTCTCCCGACAGCCTGCCAGACCCTCTTACAGACAAGGTT
ATAATGGCAGACCAAATGTAGAAGGGAAAGTCCTTCCTGGTAGTAATGGAAAACCGAATGGACAGAGAATTATCAATGGCCCTCAAGGAA
CAAAGTGGGTTGTGGACCTTGATCGTGGGTTAGTATTGAATGCAGAAGGAAGGTACCTCCAAGATTCACATGGAAATCCTCTTCGGATTA
AACTAGGAGGAGATGGTCGAACCATTGTAGATCTGGAAGGGACCCCCGTGGTGAGTCCTGACGGCCTCCCACTCTTTGGGCAGGGGCGAC
ATGGCACACCTCTGGCCAATGCCCAAGATAAGCCAATTTTGAGTCTTGGAGGAAAGCCGCTGGTGGGCTTGGAGGTCATCAAAAAAACCA
CCCATCCCCCTACCACTACCATGCAGCCCACCACTACTACGACGCCCCTGCCTACCACTACAACCCCGAGGCCCACCACTGCCACCACCC
GCCGCACGACCACCACCCGCCGCACGACCACCAGGCGTCCAACAACCACAGTCCGAACCACTACGCGGACAACCACCACCACCACCCCCA
CACCCACCACTCCCATCCCCACCTGTCCCCCTGGGACCTTGGAACGGCACGACGATGATGGCAACCTGATAATGAGCTCCAATGGGATCC
CAGAGTGCTACGCTGAAGAAGATGAGTTCTCAGGCTTGGAGACTGACACTGCAGTACCTACGGAAGAGGCCTACGTTATATATGATGAAG
ATTATGAATTTGAGACGTCAAGGCCACCAACCACCACTGAGCCTTCGACCACTGCTACCACACCGAGGGTGATCCCAGAGGAAGGCGCCA
TCAGTTCCTTTCCTGAAGAAGAATTTGATCTGGCTGGAAGGAAACGATTTGTTGCTCCTTACGTGACGTACCTAAATAAAGACCCATCAG
CCCCGTGCTCTCTGACTGATGCACTGGATCACTTCCAAGTGGACAGCCTGGATGAAATCATCCCCAATGACCTGAAGAAGAGTGACCTGC
CTCCCCAGCATGCTCCCCGCAACATCACCGTGGTGGCCGTGGAAGGTTGCCACTCATTTGTCATTGTGGACTGGGACAAAGCCACCCCAG
GAGATGTGGTCACAGGTTACTTGGTTTACAGTGCATCCTATGAAGACTTCATCAGGAACAAGTGGTCCACTCAAGCTTCATCAGTAACTC
ACTTGCCCATTGAGAACCTAAAGCCCAACACGAGGTATTATTTTAAAGTGCAAGCACAAAATCCTCATGGCTACGGACCTATCAGCCCTT
CGGTCTCATTTGTCACCGAATCAGATAATCCTCTGCTTGTTGTGAGGCCCCCAGGCGGTGAGCCTATCTGGATCCCATTCGCTTTCAAAC
ATGATCCCAGCTACACGGACTGCCATGGACGGCAATATGTGAAGCGCACGTGGTATCGAAAGTTCGTGGGAGTTGTTCTTTGTAATTCAC
TGAGGTATAAAATCTACCTCAGTGACAACCTGAAAGATACATTCTACAGCATTGGAGACAGCTGGGGAAGAGGTGAAGACCATTGCCAAT
TTGTGGATTCACACCTTGATGGAAGAACAGGGCCTCAGTCCTATGTAGAAGCCCTCCCTACTATTCAAGGCTACTATCGCCAGTATCGTC
AGGAGCCTGTCAGGTTTGGGAACATCGGCTTCGGAACCCCCTACTACTATGTGGGCTGGTACGAGTGTGGGGTCTCCATCCCTGGAAAGT
GGTAATCACAGGACCGTCATGCTGCAAGCTTGCCCTGCCCAGCCCCACCAACTAAGTCGCACTAGGGGCTGTGAGCAAAGACAGCCAGCG
TGCTCAGCCCCGCTGCCCTAGGTGCCAGGAAGGTCATAGATGGACACTGGCCATTCTGGTCATCTCAGTCTGGAACTCAGTCCCACTTCT
TGGCCTGGACAATGAACAGGATTCAGTTTTGCTGTTAACTTTGCTTCTCTACTTTTTTTTGTTTGTTTGTAATAGCACATCCCAGAGACA
TCAGAAACCAGCAACTGATTCAGTGTGATTTCCAGACTTTTTAGGCATGAAATTCGGACACTTCAGTATTTCCAGGAATAGCATATGCAC
GCTGTTCTTGCTTCATGGAATGCTACATGCTTTCTGTTTTTCTCATTTTGGATTTCTCCAAAACTAACTGAATTTAAGCTTCAGGTCCCT
TTGTATGCAGTAGAAAGGAATTATTAAAAACACCACCAAAGAAAATAAATATATCCTACTTGAAATTTACTCTATGGACTTACCCACTGC
TAGAATAAATGTATCAAATCTTATTTGTAAATTCTCAATTTTGATATATATATGTATATATGCATATACATATCCACACTTGTCTGCAAG

>In-frame_ENST00000369681_ENST00000297267_TCGA-YL-A8SP-01B_CYB5R4_chr6_84574047_+_FNDC1_chr6_159618463_length(amino acids)=1964AA_start in transcript=50_stop in transcript=5944
MASARPQSRSWRCCPVWRRSPGRARGRGLKMLNVPSQSFPAPRSQQRVASGGRSKVPLKQGRSLMDWIRLTKSGKDLTGLKGRLIEVTEE
ELKKHNKKDDCWICIRVDHPLKPRHVKLLSTKMGLKVTWDPPKDATSRPVEHYNIAYGKSLKSLKYIKVNAETYSFLIEDVEPGVVYFVL
LTAENHSGVSRPVYRAESPPGGEWIEIDGFPIKGPGPFNETVTEKEVPNKPLRVRVRSSDDRLSVAWKAPRLSGAKSPRRSRGFLLGYGE
SGRKMNYVPLTRDERTHEIKKLASESVYVVSLQSMNSQGRSQPVYRAALTKRKISEEDELDVPDDISVRVMSSQSVLVSWVDPVLEKQKK
VVASRQYTVRYREKGELARWDYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAA
SWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMPTTSKADVEQNTEDNG
KPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQ
DQKRTLRPPSRHGHSVVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPASLNDNDLVDSDED
ERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPL
SKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQTLRARPASGHFHLLRHKPFAANGR
SPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLH
RKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPV
ATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPAHAARA
KEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKG
GKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSRLPPRSAATVSPVAGTHPWPQ
YTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSYRQGYNGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEG
RYLQDSHGNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGLEVIKKTTHPPTTTMQPTTTTTPL
PTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTPTTPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDT
AVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIPEEGAISSFPEEEFDLAGRKRFVAPYVTYLNKDPSAPCSLTDALDHFQVDSL
DEIIPNDLKKSDLPPQHAPRNITVVAVEGCHSFVIVDWDKATPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNTRYYFKV
QAQNPHGYGPISPSVSFVTESDNPLLVVRPPGGEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNLKDTFYS

--------------------------------------------------------------
>In-frame_ENST00000369679_ENST00000340366_TCGA-YL-A8SP-01B_CYB5R4_chr6_84574047_+_FNDC1_chr6_159618463_length(transcript)=6406nt_BP=356nt
GCCTCACCCCTGGCGACCCCGGAAGTGGGTCGGGGGCTTGGCCTCTGCCCGGCCACAGAGCCGGAGCTGGAGGTGCTGTCCCGTCTGGCG
GCGATCCCCGGGCAGGGCCCGGGGCCGGGGTTTGAAGATGCTGAACGTCCCTTCCCAGTCTTTCCCGGCCCCCAGGTCGCAGCAGCGTGT
CGCCTCCGGGGGGCGTAGCAAGGTACCTTTAAAACAGGGCAGAAGCCTTATGGATTGGATTCGACTGACCAAAAGTGGAAAGGATCTAAC
GGGATTAAAAGGCAGGTTAATTGAAGTAACTGAAGAAGAACTTAAGAAACACAACAAAAAAGATGATTGTTGGATATGCATAAGAGTTGA
CCACCCACTGAAGCCAAGGCATGTGAAACTGCTGTCCACTAAAATGGGCCTGAAAGTCACGTGGGACCCACCCAAAGATGCTACCAGTAG
ACCTGTGGAGCATTACAACATTGCCTATGGGAAGTCACTGAAAAGTCTTAAATACATCAAGGTGAATGCGGAGACATACTCCTTCCTTAT
TGAGGATGTGGAGCCGGGGGTAGTGTACTTTGTGCTGCTTACTGCAGAAAACCACAGTGGAGTGAGCCGTCCTGTTTACAGAGCTGAAAG
CCCACCTGGAGGTGAATGGATCGAGATTGATGGTTTTCCCATTAAGGGTCCAGGACCATTTAATGAAACCGTCACAGAAAAGGAAGTGCC
CAACAAGCCCTTGCGTGTGCGTGTCCGGTCCTCAGATGACAGGCTGTCCGTTGCGTGGAAGGCACCACGCCTGTCTGGAGCCAAGAGTCC
ACGCAGATCACGGGGTTTTCTCCTGGGCTACGGGGAGAGTGGCCGGAAGATGAATTATGTTCCACTGACAAGAGATGAACGGACACACGA
AATTAAAAAGCTAGCCTCGGAATCCGTGTATGTGGTCTCCCTGCAGTCCATGAACTCTCAGGGCCGGAGCCAACCAGTCTACAGGGCTGC
CCTAACAAAGCGAAAGATTTCAGAAGAGGACGAATTGGATGTACCTGACGACATCAGCGTCCGGGTTATGTCATCTCAGTCTGTGCTTGT
GTCCTGGGTGGATCCTGTTCTGGAAAAACAGAAGAAAGTTGTTGCATCAAGACAGTACACCGTGCGCTATCGAGAGAAGGGGGAATTGGC
CAGGTGGGATTATAAGCAGATCGCTAACAGGCGTGTGCTGATTGAGAACCTGATTCCAGACACTGTGTATGAATTTGCAGTCCGTATTTC
ACAGGGTGAAAGAGATGGCAAATGGAGTACGTCAGTCTTCCAAAGAACACCAGAATCTGCCCCTACCACAGCTCCTGAAAACTTGAACGT
CTGGCCAGTCAATGGCAAACCTACAGTTGTCGCTGCATCTTGGGATGCGCTACCAGAGACTGAGGGGAAAGTGAAAGCCAGTAAGGCGGA
TGTTGAGCAGAACACGGAGGACAATGGGAAACCCGAAAAACCTGAGCCTTCCTCACCTTCTCCCAGAGCTCCAGCTTCCTCCCAACACCC
CTCTGTGCCTGCTTCTCCCCAAGGGAGAAATGCCAAGGACCTTCTTCTTGACTTGAAGAACAAAATATTGGCTAATGGTGGGGCGCCCCG
AAAACCCCAGCTTCGCGCCAAGAAGGCAGAGGAGCTGGATCTTCAGTCGACAGAAATCACTGGGGAGGAGGAGCTGGGTTCCCGGGAGGA
CTCGCCCATGTCACCCTCAGACACCCAAGACCAGAAACGGACCCTGAGGCCGCCAAGTAGACACGGCCACTCGGTGGTTGCTCCCGGCAG
GACTGCAGTGAGGGCCCGGATGCCAGCGCTGCCCCGAAGGGAAGGCGTAGATAAGCCTGGCTTTTCCCTGGCCACGCAGCCCCGCCCAGG
GGCGCCCCCCTCGGCTTCGGCCTCTCCTGCCCACCACGCGTCCACCCAGGGCACCTCTCATCGTCCTTCCCTGCCTGCCAGCTTGAATGA
CAACGACTTGGTGGACTCAGACGAAGATGAGCGCGCTGTGGGCTCCCTCCACCCCAAGGGCGCCTTCGCCCAGCCCCGGCCAGCCCTGTC
CCCCAGCCGCCAGTCCCCGTCCAGCGTTCTCCGCGACAGAAGCTCTGTGCACCCCGGCGCAAAGCCAGCCTCGCCGGCCCGGAGGACCCC
CCATTCAGGGGCCGCAGAGGAAGATTCCAGTGCCTCAGCCCCACCCTCAAGACTTTCTCCACCCCATGGGGGATCATCTCGGCTGCTGCC
CACCCAGCCACACCTGAGCTCTCCACTTTCCAAGGGCGGGAAGGATGGTGAGGACGCCCCAGCCACCAACTCCAATGCGCCATCACGGTC
CACCATGTCCTCCTCCGTCTCTTCTCATCTCTCGTCCAGGACGCAGGTCTCTGAGGGAGCGGAGGCTTCTGATGGTGAAAGCCACGGTGA
CGGCGATAGGGAAGACGGCGGAAGGCAGGCGGAGGCCACGGCCCAGACGCTGCGGGCCCGGCCTGCCTCTGGACACTTCCATTTGCTCAG
ACACAAACCCTTTGCTGCCAACGGGAGGTCTCCAAGCAGGTTCAGCATTGGGCGGGGACCTCGGCTGCAGCCCTCCAGCTCCCCACAGTC
GACTGTGCCCTCCCGAGCCCACCCCAGGGTTCCCTCTCACTCTGATTCCCACCCTAAGCTTAGCTCAGGTATCCATGGAGACGAGGAGGA
TGAGAAGCCGCTTCCTGCCACCGTTGTCAATGACCACGTGCCTTCCTCCTCCAGGCAGCCCATCTCCCGGGGCTGGGAGGACTTAAGGAG
AAGCCCGCAGAGAGGGGCCAGCCTGCATCGGAAGGAACCCATCCCAGAGAACCCCAAATCCACAGGGGCAGATACACATCCTCAGGGCAA
GTACTCCTCCCTGGCCTCCAAGGCTCAGGATGTTCAACAGAGCACAGACGCGGACACGGAGGGTCATTCTCCCAAAGCACAGCCAGGGTC
CACAGACCGCCACGCGTCCCCTGCTCGTCCGCCCGCAGCACGGTCACAGCAGCATCCCAGTGTTCCCAGAAGGATGACACCCGGCCGGGC
CCCACAACAGCAGCCCCCTCCTCCCGTCGCCACGTCCCAGCACCACCCGGGACCCCAGAGCAGAGACGCGGGTCGGTCACCTTCCCAGCC
CAGGCTCTCACTGACCCAGGCCGGGCGGCCCCGCCCCACGTCGCAGGGCCGCTCCCACTCCTCCTCGGACCCTTACACGGCGAGCTCCAG
AGGGATGCTCCCCACGGCCCTCCAGAACCAGGACGAGGATGCCCAGGGCAGCTACGACGACGACAGCACAGAAGTCGAGGCCCAGGATGT
GCGGGCCCCCGCGCACGCCGCGCGCGCCAAGGAGGCAGCTGCGTCCCTTCCCAAGCACCAGCAGGTGGAGTCTCCCACAGGCGCAGGGGC
AGGTGGCGACCACAGGTCCCAGCGCGGACATGCGGCCTCCCCCGCCAGGCCCAGCCGACCCGGCGGCCCCCAGTCCCGCGCCCGGGTACC
CAGCAGGGCAGCGCCGGGGAAGTCGGAGCCTCCTTCCAAGCGGCCCCTGTCCTCCAAGTCCCAGCAGTCGGTCTCAGCCGAGGACGACGA
GGAGGAGGACGCGGGATTTTTTAAAGGCGGGAAAGAAGACCTTCTGTCTTCCTCTGTGCCAAAGTGGCCCTCTTCCTCCACTCCCAGGGG
CGGCAAAGACGCCGATGGGAGCCTCGCCAAGGAAGAGAGGGAGCCTGCCATCGCGCTTGCCCCTCGCGGAGGGAGCCTGGCTCCTGTGAA
GCGACCTCTCCCCCCACCTCCAGGCAGCTCCCCCAGGGCCTCCCACGTCCCTTCCCGACTGCCGCCTCGCAGCGCTGCCACCGTGAGCCC
CGTCGCGGGCACCCACCCCTGGCCGCAGTACACCACGCGCGCCCCACCTGGCCACTTCTCCACCACCCCGATGCTGTCCTTGCGCCAGAG
GATGATGCATGCCAGATTCCGTAACCCTCTCTCCCGACAGCCTGCCAGACCCTCTTACAGACAAGGTTATAATGGCAGACCAAATGTAGA
AGGGAAAGTCCTTCCTGGTAGTAATGGAAAACCGAATGGACAGAGAATTATCAATGGCCCTCAAGGAACAAAGTGGGTTGTGGACCTTGA
TCGTGGGTTAGTATTGAATGCAGAAGGAAGGTACCTCCAAGATTCACATGGAAATCCTCTTCGGATTAAACTAGGAGGAGATGGTCGAAC
CATTGTAGATCTGGAAGGGACCCCCGTGGTGAGTCCTGACGGCCTCCCACTCTTTGGGCAGGGGCGACATGGCACACCTCTGGCCAATGC
CCAAGATAAGCCAATTTTGAGTCTTGGAGGAAAGCCGCTGGTGGGCTTGGAGGTCATCAAAAAAACCACCCATCCCCCTACCACTACCAT
GCAGCCCACCACTACTACGACGCCCCTGCCTACCACTACAACCCCGAGGCCCACCACTGCCACCACCCGCCGCACGACCACCACCCGCCG
CACGACCACCAGGCGTCCAACAACCACAGTCCGAACCACTACGCGGACAACCACCACCACCACCCCCACACCCACCACTCCCATCCCCAC
CTGTCCCCCTGGGACCTTGGAACGGCACGACGATGATGGCAACCTGATAATGAGCTCCAATGGGATCCCAGAGTGCTACGCTGAAGAAGA
TGAGTTCTCAGGCTTGGAGACTGACACTGCAGTACCTACGGAAGAGGCCTACGTTATATATGATGAAGATTATGAATTTGAGACGTCAAG
GCCACCAACCACCACTGAGCCTTCGACCACTGCTACCACACCGAGGGTGATCCCAGAGGAAGGCGCCATCAGTTCCTTTCCTGAAGAAGA
ATTTGATCTGGCTGGAAGGAAACGATTTGTTGCTCCTTACGTGACGTACCTAAATAAAGACCCATCAGCCCCGTGCTCTCTGACTGATGC
ACTGGATCACTTCCAAGTGGACAGCCTGGATGAAATCATCCCCAATGACCTGAAGAAGAGTGACCTGCCTCCCCAGCATGCTCCCCGCAA
CATCACCGTGGTGGCCGTGGAAGGTTGCCACTCATTTGTCATTGTGGACTGGGACAAAGCCACCCCAGGAGATGTGGTCACAGGTTACTT
GGTTTACAGTGCATCCTATGAAGACTTCATCAGGAACAAGTGGTCCACTCAAGCTTCATCAGTAACTCACTTGCCCATTGAGAACCTAAA
GCCCAACACGAGGTATTATTTTAAAGTGCAAGCACAAAATCCTCATGGCTACGGACCTATCAGCCCTTCGGTCTCATTTGTCACCGAATC
AGATAATCCTCTGCTTGTTGTGAGGCCCCCAGGCGGTGAGCCTATCTGGATCCCATTCGCTTTCAAACATGATCCCAGCTACACGGACTG
CCATGGACGGCAATATGTGAAGCGCACGTGGTATCGAAAGTTCGTGGGAGTTGTTCTTTGTAATTCACTGAGGTATAAAATCTACCTCAG
TGACAACCTGAAAGATACATTCTACAGCATTGGAGACAGCTGGGGAAGAGGTGAAGACCATTGCCAATTTGTGGATTCACACCTTGATGG
AAGAACAGGGCCTCAGTCCTATGTAGAAGCCCTCCCTACTATTCAAGGCTACTATCGCCAGTATCGTCAGGAGCCTGTCAGGTTTGGGAA
CATCGGCTTCGGAACCCCCTACTACTATGTGGGCTGGTACGAGTGTGGGGTCTCCATCCCTGGAAAGTGGTAATCACAGGACCGTCATGC
TGCAAGCTTGCCCTGCCCAGCCCCACCAACTAAGTCGCACTAGGGGCTGTGAGCAAAGACAGCCAGCGTGCTCAGCCCCGCTGCCCTAGG
TGCCAGGAAGGTCATAGATGGACACTGGCCATTCTGGTCATCTCAGTCTGGAACTCAGTCCCACTTCTTGGCCTGGACAATGAACAGGAT
TCAGTTTTGCTGTTAACTTTGCTTCTCTACTTTTTTTTGTTTGTTTGTAATAGCACATCCCAGAGACATCAGAAACCAGCAACTGATTCA
GTGTGATTTCCAGACTTTTTAGGCATGAAATTCGGACACTTCAGTATTTCCAGGAATAGCATATGCACGCTGTTCTTGCTTCATGGAATG
CTACATGCTTTCTGTTTTTCTCATTTTGGATTTCTCCAAAACTAACTGAATTTAAGCTTCAGGTCCCTTTGTATGCAGTAGAAAGGAATT
ATTAAAAACACCACCAAAGAAAATAAATATATCCTACTTGAAATTTACTCTATGGACTTACCCACTGCTAGAATAAATGTATCAAATCTT
ATTTGTAAATTCTCAATTTTGATATATATATGTATATATGCATATACATATCCACACTTGTCTGCAAGAATATTGATTAAAATTGCTAAA

>In-frame_ENST00000369679_ENST00000340366_TCGA-YL-A8SP-01B_CYB5R4_chr6_84574047_+_FNDC1_chr6_159618463_length(amino acids)=1901AA_start in transcript=37_stop in transcript=5742
MASARPQSRSWRCCPVWRRSPGRARGRGLKMLNVPSQSFPAPRSQQRVASGGRSKVPLKQGRSLMDWIRLTKSGKDLTGLKGRLIEVTEE
ELKKHNKKDDCWICIRVDHPLKPRHVKLLSTKMGLKVTWDPPKDATSRPVEHYNIAYGKSLKSLKYIKVNAETYSFLIEDVEPGVVYFVL
LTAENHSGVSRPVYRAESPPGGEWIEIDGFPIKGPGPFNETVTEKEVPNKPLRVRVRSSDDRLSVAWKAPRLSGAKSPRRSRGFLLGYGE
SGRKMNYVPLTRDERTHEIKKLASESVYVVSLQSMNSQGRSQPVYRAALTKRKISEEDELDVPDDISVRVMSSQSVLVSWVDPVLEKQKK
VVASRQYTVRYREKGELARWDYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAA
SWDALPETEGKVKASKADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEEL
DLQSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHH
ASTQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSAS
APPSRLSPPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEA
TAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDH
VPSSSRQPISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPA
ARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDE
DAQGSYDDDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPPS
KRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPR
ASHVPSRLPPRSAATVSPVAGTHPWPQYTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSYRQGYNGRPNVEGKVLPGSNGKPN
GQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKP
LVGLEVIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTPTTPIPTCPPGTLERHDDD
GNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIPEEGAISSFPEEEFDLAGRKRFVAP
YVTYLNKDPSAPCSLTDALDHFQVDSLDEIIPNDLKKSDLPPQHAPRNITVVAVEGCHSFVIVDWDKATPGDVVTGYLVYSASYEDFIRN
KWSTQASSVTHLPIENLKPNTRYYFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRPPGGEPIWIPFAFKHDPSYTDCHGRQYVKRTWYR
KFVGVVLCNSLRYKIYLSDNLKDTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYRQYRQEPVRFGNIGFGTPYYYVGW

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>In-frame_ENST00000369679_ENST00000297267_TCGA-YL-A8SP-01B_CYB5R4_chr6_84574047_+_FNDC1_chr6_159618463_length(transcript)=6599nt_BP=356nt
GCCTCACCCCTGGCGACCCCGGAAGTGGGTCGGGGGCTTGGCCTCTGCCCGGCCACAGAGCCGGAGCTGGAGGTGCTGTCCCGTCTGGCG
GCGATCCCCGGGCAGGGCCCGGGGCCGGGGTTTGAAGATGCTGAACGTCCCTTCCCAGTCTTTCCCGGCCCCCAGGTCGCAGCAGCGTGT
CGCCTCCGGGGGGCGTAGCAAGGTACCTTTAAAACAGGGCAGAAGCCTTATGGATTGGATTCGACTGACCAAAAGTGGAAAGGATCTAAC
GGGATTAAAAGGCAGGTTAATTGAAGTAACTGAAGAAGAACTTAAGAAACACAACAAAAAAGATGATTGTTGGATATGCATAAGAGTTGA
CCACCCACTGAAGCCAAGGCATGTGAAACTGCTGTCCACTAAAATGGGCCTGAAAGTCACGTGGGACCCACCCAAAGATGCTACCAGTAG
ACCTGTGGAGCATTACAACATTGCCTATGGGAAGTCACTGAAAAGTCTTAAATACATCAAGGTGAATGCGGAGACATACTCCTTCCTTAT
TGAGGATGTGGAGCCGGGGGTAGTGTACTTTGTGCTGCTTACTGCAGAAAACCACAGTGGAGTGAGCCGTCCTGTTTACAGAGCTGAAAG
CCCACCTGGAGGTGAATGGATCGAGATTGATGGTTTTCCCATTAAGGGTCCAGGACCATTTAATGAAACCGTCACAGAAAAGGAAGTGCC
CAACAAGCCCTTGCGTGTGCGTGTCCGGTCCTCAGATGACAGGCTGTCCGTTGCGTGGAAGGCACCACGCCTGTCTGGAGCCAAGAGTCC
ACGCAGATCACGGGGTTTTCTCCTGGGCTACGGGGAGAGTGGCCGGAAGATGAATTATGTTCCACTGACAAGAGATGAACGGACACACGA
AATTAAAAAGCTAGCCTCGGAATCCGTGTATGTGGTCTCCCTGCAGTCCATGAACTCTCAGGGCCGGAGCCAACCAGTCTACAGGGCTGC
CCTAACAAAGCGAAAGATTTCAGAAGAGGACGAATTGGATGTACCTGACGACATCAGCGTCCGGGTTATGTCATCTCAGTCTGTGCTTGT
GTCCTGGGTGGATCCTGTTCTGGAAAAACAGAAGAAAGTTGTTGCATCAAGACAGTACACCGTGCGCTATCGAGAGAAGGGGGAATTGGC
CAGGTGGGATTATAAGCAGATCGCTAACAGGCGTGTGCTGATTGAGAACCTGATTCCAGACACTGTGTATGAATTTGCAGTCCGTATTTC
ACAGGGTGAAAGAGATGGCAAATGGAGTACGTCAGTCTTCCAAAGAACACCAGAATCTGCCCCTACCACAGCTCCTGAAAACTTGAACGT
CTGGCCAGTCAATGGCAAACCTACAGTTGTCGCTGCATCTTGGGATGCGCTACCAGAGACTGAGGGGAAAGTGAAAGAATACATTCTTTC
ATACGCCCCGGCTCTCAAACCATTTGGAGCAAAGTCCCTCACCTATCCTGGAGACACTACTTCTGCCCTGGTGGATGGTCTGCAGCCTGG
GGAACGCTATCTTTTCAAAATCCGGGCCACAAACAGGAGAGGCCTGGGACCTCACTCCAAAGCCTTCATTGTCGCTATGCCAACAACCAG
TAAGGCGGATGTTGAGCAGAACACGGAGGACAATGGGAAACCCGAAAAACCTGAGCCTTCCTCACCTTCTCCCAGAGCTCCAGCTTCCTC
CCAACACCCCTCTGTGCCTGCTTCTCCCCAAGGGAGAAATGCCAAGGACCTTCTTCTTGACTTGAAGAACAAAATATTGGCTAATGGTGG
GGCGCCCCGAAAACCCCAGCTTCGCGCCAAGAAGGCAGAGGAGCTGGATCTTCAGTCGACAGAAATCACTGGGGAGGAGGAGCTGGGTTC
CCGGGAGGACTCGCCCATGTCACCCTCAGACACCCAAGACCAGAAACGGACCCTGAGGCCGCCAAGTAGACACGGCCACTCGGTGGTTGC
TCCCGGCAGGACTGCAGTGAGGGCCCGGATGCCAGCGCTGCCCCGAAGGGAAGGCGTAGATAAGCCTGGCTTTTCCCTGGCCACGCAGCC
CCGCCCAGGGGCGCCCCCCTCGGCTTCGGCCTCTCCTGCCCACCACGCGTCCACCCAGGGCACCTCTCATCGTCCTTCCCTGCCTGCCAG
CTTGAATGACAACGACTTGGTGGACTCAGACGAAGATGAGCGCGCTGTGGGCTCCCTCCACCCCAAGGGCGCCTTCGCCCAGCCCCGGCC
AGCCCTGTCCCCCAGCCGCCAGTCCCCGTCCAGCGTTCTCCGCGACAGAAGCTCTGTGCACCCCGGCGCAAAGCCAGCCTCGCCGGCCCG
GAGGACCCCCCATTCAGGGGCCGCAGAGGAAGATTCCAGTGCCTCAGCCCCACCCTCAAGACTTTCTCCACCCCATGGGGGATCATCTCG
GCTGCTGCCCACCCAGCCACACCTGAGCTCTCCACTTTCCAAGGGCGGGAAGGATGGTGAGGACGCCCCAGCCACCAACTCCAATGCGCC
ATCACGGTCCACCATGTCCTCCTCCGTCTCTTCTCATCTCTCGTCCAGGACGCAGGTCTCTGAGGGAGCGGAGGCTTCTGATGGTGAAAG
CCACGGTGACGGCGATAGGGAAGACGGCGGAAGGCAGGCGGAGGCCACGGCCCAGACGCTGCGGGCCCGGCCTGCCTCTGGACACTTCCA
TTTGCTCAGACACAAACCCTTTGCTGCCAACGGGAGGTCTCCAAGCAGGTTCAGCATTGGGCGGGGACCTCGGCTGCAGCCCTCCAGCTC
CCCACAGTCGACTGTGCCCTCCCGAGCCCACCCCAGGGTTCCCTCTCACTCTGATTCCCACCCTAAGCTTAGCTCAGGTATCCATGGAGA
CGAGGAGGATGAGAAGCCGCTTCCTGCCACCGTTGTCAATGACCACGTGCCTTCCTCCTCCAGGCAGCCCATCTCCCGGGGCTGGGAGGA
CTTAAGGAGAAGCCCGCAGAGAGGGGCCAGCCTGCATCGGAAGGAACCCATCCCAGAGAACCCCAAATCCACAGGGGCAGATACACATCC
TCAGGGCAAGTACTCCTCCCTGGCCTCCAAGGCTCAGGATGTTCAACAGAGCACAGACGCGGACACGGAGGGTCATTCTCCCAAAGCACA
GCCAGGGTCCACAGACCGCCACGCGTCCCCTGCTCGTCCGCCCGCAGCACGGTCACAGCAGCATCCCAGTGTTCCCAGAAGGATGACACC
CGGCCGGGCCCCACAACAGCAGCCCCCTCCTCCCGTCGCCACGTCCCAGCACCACCCGGGACCCCAGAGCAGAGACGCGGGTCGGTCACC
TTCCCAGCCCAGGCTCTCACTGACCCAGGCCGGGCGGCCCCGCCCCACGTCGCAGGGCCGCTCCCACTCCTCCTCGGACCCTTACACGGC
GAGCTCCAGAGGGATGCTCCCCACGGCCCTCCAGAACCAGGACGAGGATGCCCAGGGCAGCTACGACGACGACAGCACAGAAGTCGAGGC
CCAGGATGTGCGGGCCCCCGCGCACGCCGCGCGCGCCAAGGAGGCAGCTGCGTCCCTTCCCAAGCACCAGCAGGTGGAGTCTCCCACAGG
CGCAGGGGCAGGTGGCGACCACAGGTCCCAGCGCGGACATGCGGCCTCCCCCGCCAGGCCCAGCCGACCCGGCGGCCCCCAGTCCCGCGC
CCGGGTACCCAGCAGGGCAGCGCCGGGGAAGTCGGAGCCTCCTTCCAAGCGGCCCCTGTCCTCCAAGTCCCAGCAGTCGGTCTCAGCCGA
GGACGACGAGGAGGAGGACGCGGGATTTTTTAAAGGCGGGAAAGAAGACCTTCTGTCTTCCTCTGTGCCAAAGTGGCCCTCTTCCTCCAC
TCCCAGGGGCGGCAAAGACGCCGATGGGAGCCTCGCCAAGGAAGAGAGGGAGCCTGCCATCGCGCTTGCCCCTCGCGGAGGGAGCCTGGC
TCCTGTGAAGCGACCTCTCCCCCCACCTCCAGGCAGCTCCCCCAGGGCCTCCCACGTCCCTTCCCGACTGCCGCCTCGCAGCGCTGCCAC
CGTGAGCCCCGTCGCGGGCACCCACCCCTGGCCGCAGTACACCACGCGCGCCCCACCTGGCCACTTCTCCACCACCCCGATGCTGTCCTT
GCGCCAGAGGATGATGCATGCCAGATTCCGTAACCCTCTCTCCCGACAGCCTGCCAGACCCTCTTACAGACAAGGTTATAATGGCAGACC
AAATGTAGAAGGGAAAGTCCTTCCTGGTAGTAATGGAAAACCGAATGGACAGAGAATTATCAATGGCCCTCAAGGAACAAAGTGGGTTGT
GGACCTTGATCGTGGGTTAGTATTGAATGCAGAAGGAAGGTACCTCCAAGATTCACATGGAAATCCTCTTCGGATTAAACTAGGAGGAGA
TGGTCGAACCATTGTAGATCTGGAAGGGACCCCCGTGGTGAGTCCTGACGGCCTCCCACTCTTTGGGCAGGGGCGACATGGCACACCTCT
GGCCAATGCCCAAGATAAGCCAATTTTGAGTCTTGGAGGAAAGCCGCTGGTGGGCTTGGAGGTCATCAAAAAAACCACCCATCCCCCTAC
CACTACCATGCAGCCCACCACTACTACGACGCCCCTGCCTACCACTACAACCCCGAGGCCCACCACTGCCACCACCCGCCGCACGACCAC
CACCCGCCGCACGACCACCAGGCGTCCAACAACCACAGTCCGAACCACTACGCGGACAACCACCACCACCACCCCCACACCCACCACTCC
CATCCCCACCTGTCCCCCTGGGACCTTGGAACGGCACGACGATGATGGCAACCTGATAATGAGCTCCAATGGGATCCCAGAGTGCTACGC
TGAAGAAGATGAGTTCTCAGGCTTGGAGACTGACACTGCAGTACCTACGGAAGAGGCCTACGTTATATATGATGAAGATTATGAATTTGA
GACGTCAAGGCCACCAACCACCACTGAGCCTTCGACCACTGCTACCACACCGAGGGTGATCCCAGAGGAAGGCGCCATCAGTTCCTTTCC
TGAAGAAGAATTTGATCTGGCTGGAAGGAAACGATTTGTTGCTCCTTACGTGACGTACCTAAATAAAGACCCATCAGCCCCGTGCTCTCT
GACTGATGCACTGGATCACTTCCAAGTGGACAGCCTGGATGAAATCATCCCCAATGACCTGAAGAAGAGTGACCTGCCTCCCCAGCATGC
TCCCCGCAACATCACCGTGGTGGCCGTGGAAGGTTGCCACTCATTTGTCATTGTGGACTGGGACAAAGCCACCCCAGGAGATGTGGTCAC
AGGTTACTTGGTTTACAGTGCATCCTATGAAGACTTCATCAGGAACAAGTGGTCCACTCAAGCTTCATCAGTAACTCACTTGCCCATTGA
GAACCTAAAGCCCAACACGAGGTATTATTTTAAAGTGCAAGCACAAAATCCTCATGGCTACGGACCTATCAGCCCTTCGGTCTCATTTGT
CACCGAATCAGATAATCCTCTGCTTGTTGTGAGGCCCCCAGGCGGTGAGCCTATCTGGATCCCATTCGCTTTCAAACATGATCCCAGCTA
CACGGACTGCCATGGACGGCAATATGTGAAGCGCACGTGGTATCGAAAGTTCGTGGGAGTTGTTCTTTGTAATTCACTGAGGTATAAAAT
CTACCTCAGTGACAACCTGAAAGATACATTCTACAGCATTGGAGACAGCTGGGGAAGAGGTGAAGACCATTGCCAATTTGTGGATTCACA
CCTTGATGGAAGAACAGGGCCTCAGTCCTATGTAGAAGCCCTCCCTACTATTCAAGGCTACTATCGCCAGTATCGTCAGGAGCCTGTCAG
GTTTGGGAACATCGGCTTCGGAACCCCCTACTACTATGTGGGCTGGTACGAGTGTGGGGTCTCCATCCCTGGAAAGTGGTAATCACAGGA
CCGTCATGCTGCAAGCTTGCCCTGCCCAGCCCCACCAACTAAGTCGCACTAGGGGCTGTGAGCAAAGACAGCCAGCGTGCTCAGCCCCGC
TGCCCTAGGTGCCAGGAAGGTCATAGATGGACACTGGCCATTCTGGTCATCTCAGTCTGGAACTCAGTCCCACTTCTTGGCCTGGACAAT
GAACAGGATTCAGTTTTGCTGTTAACTTTGCTTCTCTACTTTTTTTTGTTTGTTTGTAATAGCACATCCCAGAGACATCAGAAACCAGCA
ACTGATTCAGTGTGATTTCCAGACTTTTTAGGCATGAAATTCGGACACTTCAGTATTTCCAGGAATAGCATATGCACGCTGTTCTTGCTT
CATGGAATGCTACATGCTTTCTGTTTTTCTCATTTTGGATTTCTCCAAAACTAACTGAATTTAAGCTTCAGGTCCCTTTGTATGCAGTAG
AAAGGAATTATTAAAAACACCACCAAAGAAAATAAATATATCCTACTTGAAATTTACTCTATGGACTTACCCACTGCTAGAATAAATGTA
TCAAATCTTATTTGTAAATTCTCAATTTTGATATATATATGTATATATGCATATACATATCCACACTTGTCTGCAAGAATATTGATTAAA

>In-frame_ENST00000369679_ENST00000297267_TCGA-YL-A8SP-01B_CYB5R4_chr6_84574047_+_FNDC1_chr6_159618463_length(amino acids)=1964AA_start in transcript=37_stop in transcript=5931
MASARPQSRSWRCCPVWRRSPGRARGRGLKMLNVPSQSFPAPRSQQRVASGGRSKVPLKQGRSLMDWIRLTKSGKDLTGLKGRLIEVTEE
ELKKHNKKDDCWICIRVDHPLKPRHVKLLSTKMGLKVTWDPPKDATSRPVEHYNIAYGKSLKSLKYIKVNAETYSFLIEDVEPGVVYFVL
LTAENHSGVSRPVYRAESPPGGEWIEIDGFPIKGPGPFNETVTEKEVPNKPLRVRVRSSDDRLSVAWKAPRLSGAKSPRRSRGFLLGYGE
SGRKMNYVPLTRDERTHEIKKLASESVYVVSLQSMNSQGRSQPVYRAALTKRKISEEDELDVPDDISVRVMSSQSVLVSWVDPVLEKQKK
VVASRQYTVRYREKGELARWDYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAA
SWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMPTTSKADVEQNTEDNG
KPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQ
DQKRTLRPPSRHGHSVVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPASLNDNDLVDSDED
ERAVGSLHPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPL
SKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEATAQTLRARPASGHFHLLRHKPFAANGR
SPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPISRGWEDLRRSPQRGASLH
RKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPV
ATSQHHPGPQSRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEAQDVRAPAHAARA
KEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKG
GKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSRLPPRSAATVSPVAGTHPWPQ
YTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSYRQGYNGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEG
RYLQDSHGNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGLEVIKKTTHPPTTTMQPTTTTTPL
PTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTTTTPTPTTPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDT
AVPTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIPEEGAISSFPEEEFDLAGRKRFVAPYVTYLNKDPSAPCSLTDALDHFQVDSL
DEIIPNDLKKSDLPPQHAPRNITVVAVEGCHSFVIVDWDKATPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNTRYYFKV
QAQNPHGYGPISPSVSFVTESDNPLLVVRPPGGEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVVLCNSLRYKIYLSDNLKDTFYS

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Fusion Gene PPI Analysis for CYB5R4-FNDC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CYB5R4-FNDC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CYB5R4-FNDC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource