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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADAM17-SEC31A (FusionGDB2 ID:2099)

Fusion Gene Summary for ADAM17-SEC31A

check button Fusion gene summary
Fusion gene informationFusion gene name: ADAM17-SEC31A
Fusion gene ID: 2099
HgeneTgene
Gene symbol

ADAM17

SEC31A

Gene ID

6868

22872

Gene nameADAM metallopeptidase domain 17SEC31 homolog A, COPII coat complex component
SynonymsADAM18|CD156B|CSVP|NISBD|NISBD1|TACEABP125|ABP130|HSPC275|HSPC334|NEDSOSB|SEC31L1
Cytomap

2p25.1

4q21.22

Type of geneprotein-codingprotein-coding
Descriptiondisintegrin and metalloproteinase domain-containing protein 17ADAM metallopeptidase domain 18TNF-alpha convertaseTNF-alpha converting enzymesnake venom-like proteasetumor necrosis factor, alpha, converting enzymeprotein transport protein Sec31ASEC31 homolog A, COPII coating complex componentSEC31-like protein 1SEC31-related protein Aweb1-like proteinyeast Sec31p homolog
Modification date2020032020200313
UniProtAcc

P78536

O94979

Ensembl transtripts involved in fusion geneENST00000310823, ENST00000497134, 
ENST00000348405, ENST00000513858, 
ENST00000395310, ENST00000443462, 
ENST00000509142, ENST00000326950, 
ENST00000432794, ENST00000311785, 
ENST00000448323, ENST00000505472, 
ENST00000500777, ENST00000508502, 
ENST00000355196, ENST00000264405, 
ENST00000505984, ENST00000508479, 
ENST00000436790, 
Fusion gene scores* DoF score6 X 8 X 6=28827 X 19 X 11=5643
# samples 1128
** MAII scorelog2(11/288*10)=-1.38856528791765
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(28/5643*10)=-4.33296361729939
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADAM17 [Title/Abstract] AND SEC31A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADAM17(9634765)-SEC31A(83765662), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADAM17

GO:0001666

response to hypoxia

18276953

HgeneADAM17

GO:0006508

proteolysis

24227843

HgeneADAM17

GO:0006509

membrane protein ectodomain proteolysis

9034190|9574564|17786981|18676862

HgeneADAM17

GO:0007155

cell adhesion

14970227

HgeneADAM17

GO:0007173

epidermal growth factor receptor signaling pathway

12743035

HgeneADAM17

GO:0007220

Notch receptor processing

24226769

HgeneADAM17

GO:0032496

response to lipopolysaccharide

18383040

HgeneADAM17

GO:0033627

cell adhesion mediated by integrin

14970227

HgeneADAM17

GO:0043536

positive regulation of blood vessel endothelial cell migration

24813629

HgeneADAM17

GO:0045741

positive regulation of epidermal growth factor-activated receptor activity

18483258

HgeneADAM17

GO:0051088

PMA-inducible membrane protein ectodomain proteolysis

14625290|15691827|17010968

HgeneADAM17

GO:0071403

cellular response to high density lipoprotein particle stimulus

17786981

HgeneADAM17

GO:1905564

positive regulation of vascular endothelial cell proliferation

24813629

TgeneSEC31A

GO:0051592

response to calcium ion

17196169

TgeneSEC31A

GO:0090110

cargo loading into COPII-coated vesicle

17499046|18843296


check buttonFusion gene breakpoints across ADAM17 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SEC31A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-VR-A8EUADAM17chr2

9634765

-SEC31Achr4

83765662

-


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Fusion Gene ORF analysis for ADAM17-SEC31A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000310823ENST00000348405ADAM17chr2

9634765

-SEC31Achr4

83765662

-
In-frameENST00000310823ENST00000513858ADAM17chr2

9634765

-SEC31Achr4

83765662

-
In-frameENST00000310823ENST00000395310ADAM17chr2

9634765

-SEC31Achr4

83765662

-
In-frameENST00000310823ENST00000443462ADAM17chr2

9634765

-SEC31Achr4

83765662

-
In-frameENST00000310823ENST00000509142ADAM17chr2

9634765

-SEC31Achr4

83765662

-
In-frameENST00000310823ENST00000326950ADAM17chr2

9634765

-SEC31Achr4

83765662

-
In-frameENST00000310823ENST00000432794ADAM17chr2

9634765

-SEC31Achr4

83765662

-
In-frameENST00000310823ENST00000311785ADAM17chr2

9634765

-SEC31Achr4

83765662

-
In-frameENST00000310823ENST00000448323ADAM17chr2

9634765

-SEC31Achr4

83765662

-
In-frameENST00000310823ENST00000505472ADAM17chr2

9634765

-SEC31Achr4

83765662

-
In-frameENST00000310823ENST00000500777ADAM17chr2

9634765

-SEC31Achr4

83765662

-
In-frameENST00000310823ENST00000508502ADAM17chr2

9634765

-SEC31Achr4

83765662

-
In-frameENST00000310823ENST00000355196ADAM17chr2

9634765

-SEC31Achr4

83765662

-
In-frameENST00000310823ENST00000264405ADAM17chr2

9634765

-SEC31Achr4

83765662

-
In-frameENST00000310823ENST00000505984ADAM17chr2

9634765

-SEC31Achr4

83765662

-
In-frameENST00000310823ENST00000508479ADAM17chr2

9634765

-SEC31Achr4

83765662

-
5CDS-intronENST00000310823ENST00000436790ADAM17chr2

9634765

-SEC31Achr4

83765662

-
intron-3CDSENST00000497134ENST00000348405ADAM17chr2

9634765

-SEC31Achr4

83765662

-
intron-3CDSENST00000497134ENST00000513858ADAM17chr2

9634765

-SEC31Achr4

83765662

-
intron-3CDSENST00000497134ENST00000395310ADAM17chr2

9634765

-SEC31Achr4

83765662

-
intron-3CDSENST00000497134ENST00000443462ADAM17chr2

9634765

-SEC31Achr4

83765662

-
intron-3CDSENST00000497134ENST00000509142ADAM17chr2

9634765

-SEC31Achr4

83765662

-
intron-3CDSENST00000497134ENST00000326950ADAM17chr2

9634765

-SEC31Achr4

83765662

-
intron-3CDSENST00000497134ENST00000432794ADAM17chr2

9634765

-SEC31Achr4

83765662

-
intron-3CDSENST00000497134ENST00000311785ADAM17chr2

9634765

-SEC31Achr4

83765662

-
intron-3CDSENST00000497134ENST00000448323ADAM17chr2

9634765

-SEC31Achr4

83765662

-
intron-3CDSENST00000497134ENST00000505472ADAM17chr2

9634765

-SEC31Achr4

83765662

-
intron-3CDSENST00000497134ENST00000500777ADAM17chr2

9634765

-SEC31Achr4

83765662

-
intron-3CDSENST00000497134ENST00000508502ADAM17chr2

9634765

-SEC31Achr4

83765662

-
intron-3CDSENST00000497134ENST00000355196ADAM17chr2

9634765

-SEC31Achr4

83765662

-
intron-3CDSENST00000497134ENST00000264405ADAM17chr2

9634765

-SEC31Achr4

83765662

-
intron-3CDSENST00000497134ENST00000505984ADAM17chr2

9634765

-SEC31Achr4

83765662

-
intron-3CDSENST00000497134ENST00000508479ADAM17chr2

9634765

-SEC31Achr4

83765662

-
intron-intronENST00000497134ENST00000436790ADAM17chr2

9634765

-SEC31Achr4

83765662

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000310823ADAM17chr29634765-ENST00000348405SEC31Achr483765662-3671209718332571024
ENST00000310823ADAM17chr29634765-ENST00000513858SEC31Achr483765662-332920971832915910
ENST00000310823ADAM17chr29634765-ENST00000395310SEC31Achr483765662-3671209718332571024
ENST00000310823ADAM17chr29634765-ENST00000443462SEC31Achr483765662-3625209718332121009
ENST00000310823ADAM17chr29634765-ENST00000509142SEC31Achr483765662-332820971832915910
ENST00000310823ADAM17chr29634765-ENST00000326950SEC31Achr483765662-3670209718332571024
ENST00000310823ADAM17chr29634765-ENST00000432794SEC31Achr483765662-3709209718332961037
ENST00000310823ADAM17chr29634765-ENST00000311785SEC31Achr483765662-332820971832915910
ENST00000310823ADAM17chr29634765-ENST00000448323SEC31Achr483765662-3670209718332571024
ENST00000310823ADAM17chr29634765-ENST00000505472SEC31Achr483765662-3660209718332571024
ENST00000310823ADAM17chr29634765-ENST00000500777SEC31Achr483765662-331820971832915910
ENST00000310823ADAM17chr29634765-ENST00000508502SEC31Achr483765662-3276209718332121009
ENST00000310823ADAM17chr29634765-ENST00000355196SEC31Achr483765662-3321209718332571024
ENST00000310823ADAM17chr29634765-ENST00000264405SEC31Achr483765662-3265209718332121009
ENST00000310823ADAM17chr29634765-ENST00000505984SEC31Achr483765662-3243209718332121009
ENST00000310823ADAM17chr29634765-ENST00000508479SEC31Achr483765662-292220971832228681

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000310823ENST00000348405ADAM17chr29634765-SEC31Achr483765662-0.0003837990.99961615
ENST00000310823ENST00000513858ADAM17chr29634765-SEC31Achr483765662-0.0004556550.9995443
ENST00000310823ENST00000395310ADAM17chr29634765-SEC31Achr483765662-0.0003837990.99961615
ENST00000310823ENST00000443462ADAM17chr29634765-SEC31Achr483765662-0.0003970120.999603
ENST00000310823ENST00000509142ADAM17chr29634765-SEC31Achr483765662-0.0004568080.9995432
ENST00000310823ENST00000326950ADAM17chr29634765-SEC31Achr483765662-0.0003839470.999616
ENST00000310823ENST00000432794ADAM17chr29634765-SEC31Achr483765662-0.0004572060.99954283
ENST00000310823ENST00000311785ADAM17chr29634765-SEC31Achr483765662-0.0004568080.9995432
ENST00000310823ENST00000448323ADAM17chr29634765-SEC31Achr483765662-0.0003839470.999616
ENST00000310823ENST00000505472ADAM17chr29634765-SEC31Achr483765662-0.0004038340.9995962
ENST00000310823ENST00000500777ADAM17chr29634765-SEC31Achr483765662-0.0004818110.99951816
ENST00000310823ENST00000508502ADAM17chr29634765-SEC31Achr483765662-0.0004619020.99953806
ENST00000310823ENST00000355196ADAM17chr29634765-SEC31Achr483765662-0.0004441520.9995559
ENST00000310823ENST00000264405ADAM17chr29634765-SEC31Achr483765662-0.0005093040.9994906
ENST00000310823ENST00000505984ADAM17chr29634765-SEC31Achr483765662-0.0005172990.99948263
ENST00000310823ENST00000508479ADAM17chr29634765-SEC31Achr483765662-0.0004114180.99958855

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Fusion Genomic Features for ADAM17-SEC31A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ADAM17-SEC31A


check button Go to

FGviewer for the breakpoints of chr2:9634765-chr4:83765662

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADAM17

P78536

SEC31A

O94979

FUNCTION: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form (PubMed:9034191). Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein (PubMed:12441351). Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) (PubMed:24226769). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R (PubMed:26876177, PubMed:28060820). {ECO:0000250|UniProtKB:Q9Z0F8, ECO:0000269|PubMed:12441351, ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:24226769, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:26876177, ECO:0000269|PubMed:28060820, ECO:0000269|PubMed:9034191}.FUNCTION: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). {ECO:0000250|UniProtKB:Q9Z2Q1, ECO:0000269|PubMed:10788476}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAM17chr2:9634765chr4:83765662ENST00000310823-1519564_602638.0825.0Compositional biasNote=Cys-rich
HgeneADAM17chr2:9634765chr4:83765662ENST00000310823-151996_99638.0825.0Compositional biasNote=Poly-Val
HgeneADAM17chr2:9634765chr4:83765662ENST00000310823-1519223_474638.0825.0DomainPeptidase M12B
HgeneADAM17chr2:9634765chr4:83765662ENST00000310823-1519475_563638.0825.0DomainDisintegrin
HgeneADAM17chr2:9634765chr4:83765662ENST00000310823-1519182_189638.0825.0MotifCysteine switch
TgeneSEC31Achr2:9634765chr4:83765662ENST000003269501725800_1091795.01182.0Compositional biasNote=Pro-rich
TgeneSEC31Achr2:9634765chr4:83765662ENST000003484051725800_1091795.01182.0Compositional biasNote=Pro-rich
TgeneSEC31Achr2:9634765chr4:83765662ENST000005007771623800_1091795.01068.0Compositional biasNote=Pro-rich
TgeneSEC31Achr2:9634765chr4:83765662ENST000005138581724800_1091795.01068.0Compositional biasNote=Pro-rich
TgeneSEC31Achr2:9634765chr4:83765662ENST000003117851926842_848834.01107.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr2:9634765chr4:83765662ENST000003269501725842_848795.01182.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr2:9634765chr4:83765662ENST000003484051725842_848795.01182.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr2:9634765chr4:83765662ENST000003551962129842_848834.01221.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr2:9634765chr4:83765662ENST000003953101927842_848834.01221.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr2:9634765chr4:83765662ENST000004327941928842_848834.01234.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr2:9634765chr4:83765662ENST000004434621826842_848829.01201.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr2:9634765chr4:83765662ENST000004483231927842_848834.01221.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr2:9634765chr4:83765662ENST000005007771623842_848795.01068.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr2:9634765chr4:83765662ENST000005085021927842_848834.01206.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr2:9634765chr4:83765662ENST000005091421926842_848834.01107.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C
TgeneSEC31Achr2:9634765chr4:83765662ENST000005138581724842_848795.01068.0MotifNote=ALG-2-binding site motif-2 (ABS-2)%2C

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAM17chr2:9634765chr4:83765662ENST00000310823-1519731_738638.0825.0MotifSH3-binding
HgeneADAM17chr2:9634765chr4:83765662ENST00000310823-1519741_748638.0825.0MotifSH3-binding
HgeneADAM17chr2:9634765chr4:83765662ENST00000310823-1519603_671638.0825.0RegionNote=Crambin-like
HgeneADAM17chr2:9634765chr4:83765662ENST00000310823-1519215_671638.0825.0Topological domainExtracellular
HgeneADAM17chr2:9634765chr4:83765662ENST00000310823-1519693_824638.0825.0Topological domainCytoplasmic
HgeneADAM17chr2:9634765chr4:83765662ENST00000310823-1519672_692638.0825.0TransmembraneHelical
TgeneSEC31Achr2:9634765chr4:83765662ENST000003117851926800_1091834.01107.0Compositional biasNote=Pro-rich
TgeneSEC31Achr2:9634765chr4:83765662ENST000003551962129800_1091834.01221.0Compositional biasNote=Pro-rich
TgeneSEC31Achr2:9634765chr4:83765662ENST000003953101927800_1091834.01221.0Compositional biasNote=Pro-rich
TgeneSEC31Achr2:9634765chr4:83765662ENST000004327941928800_1091834.01234.0Compositional biasNote=Pro-rich
TgeneSEC31Achr2:9634765chr4:83765662ENST000004434621826800_1091829.01201.0Compositional biasNote=Pro-rich
TgeneSEC31Achr2:9634765chr4:83765662ENST000004483231927800_1091834.01221.0Compositional biasNote=Pro-rich
TgeneSEC31Achr2:9634765chr4:83765662ENST000005085021927800_1091834.01206.0Compositional biasNote=Pro-rich
TgeneSEC31Achr2:9634765chr4:83765662ENST000005091421926800_1091834.01107.0Compositional biasNote=Pro-rich
TgeneSEC31Achr2:9634765chr4:83765662ENST000003117851926120_160834.01107.0RepeatNote=WD 3
TgeneSEC31Achr2:9634765chr4:83765662ENST000003117851926166_206834.01107.0RepeatNote=WD 4
TgeneSEC31Achr2:9634765chr4:83765662ENST000003117851926209_254834.01107.0RepeatNote=WD 5
TgeneSEC31Achr2:9634765chr4:83765662ENST000003117851926258_298834.01107.0RepeatNote=WD 6
TgeneSEC31Achr2:9634765chr4:83765662ENST000003117851926301_342834.01107.0RepeatNote=WD 7
TgeneSEC31Achr2:9634765chr4:83765662ENST0000031178519264_47834.01107.0RepeatNote=WD 1
TgeneSEC31Achr2:9634765chr4:83765662ENST00000311785192668_111834.01107.0RepeatNote=WD 2
TgeneSEC31Achr2:9634765chr4:83765662ENST000003269501725120_160795.01182.0RepeatNote=WD 3
TgeneSEC31Achr2:9634765chr4:83765662ENST000003269501725166_206795.01182.0RepeatNote=WD 4
TgeneSEC31Achr2:9634765chr4:83765662ENST000003269501725209_254795.01182.0RepeatNote=WD 5
TgeneSEC31Achr2:9634765chr4:83765662ENST000003269501725258_298795.01182.0RepeatNote=WD 6
TgeneSEC31Achr2:9634765chr4:83765662ENST000003269501725301_342795.01182.0RepeatNote=WD 7
TgeneSEC31Achr2:9634765chr4:83765662ENST0000032695017254_47795.01182.0RepeatNote=WD 1
TgeneSEC31Achr2:9634765chr4:83765662ENST00000326950172568_111795.01182.0RepeatNote=WD 2
TgeneSEC31Achr2:9634765chr4:83765662ENST000003484051725120_160795.01182.0RepeatNote=WD 3
TgeneSEC31Achr2:9634765chr4:83765662ENST000003484051725166_206795.01182.0RepeatNote=WD 4
TgeneSEC31Achr2:9634765chr4:83765662ENST000003484051725209_254795.01182.0RepeatNote=WD 5
TgeneSEC31Achr2:9634765chr4:83765662ENST000003484051725258_298795.01182.0RepeatNote=WD 6
TgeneSEC31Achr2:9634765chr4:83765662ENST000003484051725301_342795.01182.0RepeatNote=WD 7
TgeneSEC31Achr2:9634765chr4:83765662ENST0000034840517254_47795.01182.0RepeatNote=WD 1
TgeneSEC31Achr2:9634765chr4:83765662ENST00000348405172568_111795.01182.0RepeatNote=WD 2
TgeneSEC31Achr2:9634765chr4:83765662ENST000003551962129120_160834.01221.0RepeatNote=WD 3
TgeneSEC31Achr2:9634765chr4:83765662ENST000003551962129166_206834.01221.0RepeatNote=WD 4
TgeneSEC31Achr2:9634765chr4:83765662ENST000003551962129209_254834.01221.0RepeatNote=WD 5
TgeneSEC31Achr2:9634765chr4:83765662ENST000003551962129258_298834.01221.0RepeatNote=WD 6
TgeneSEC31Achr2:9634765chr4:83765662ENST000003551962129301_342834.01221.0RepeatNote=WD 7
TgeneSEC31Achr2:9634765chr4:83765662ENST0000035519621294_47834.01221.0RepeatNote=WD 1
TgeneSEC31Achr2:9634765chr4:83765662ENST00000355196212968_111834.01221.0RepeatNote=WD 2
TgeneSEC31Achr2:9634765chr4:83765662ENST000003953101927120_160834.01221.0RepeatNote=WD 3
TgeneSEC31Achr2:9634765chr4:83765662ENST000003953101927166_206834.01221.0RepeatNote=WD 4
TgeneSEC31Achr2:9634765chr4:83765662ENST000003953101927209_254834.01221.0RepeatNote=WD 5
TgeneSEC31Achr2:9634765chr4:83765662ENST000003953101927258_298834.01221.0RepeatNote=WD 6
TgeneSEC31Achr2:9634765chr4:83765662ENST000003953101927301_342834.01221.0RepeatNote=WD 7
TgeneSEC31Achr2:9634765chr4:83765662ENST0000039531019274_47834.01221.0RepeatNote=WD 1
TgeneSEC31Achr2:9634765chr4:83765662ENST00000395310192768_111834.01221.0RepeatNote=WD 2
TgeneSEC31Achr2:9634765chr4:83765662ENST000004327941928120_160834.01234.0RepeatNote=WD 3
TgeneSEC31Achr2:9634765chr4:83765662ENST000004327941928166_206834.01234.0RepeatNote=WD 4
TgeneSEC31Achr2:9634765chr4:83765662ENST000004327941928209_254834.01234.0RepeatNote=WD 5
TgeneSEC31Achr2:9634765chr4:83765662ENST000004327941928258_298834.01234.0RepeatNote=WD 6
TgeneSEC31Achr2:9634765chr4:83765662ENST000004327941928301_342834.01234.0RepeatNote=WD 7
TgeneSEC31Achr2:9634765chr4:83765662ENST0000043279419284_47834.01234.0RepeatNote=WD 1
TgeneSEC31Achr2:9634765chr4:83765662ENST00000432794192868_111834.01234.0RepeatNote=WD 2
TgeneSEC31Achr2:9634765chr4:83765662ENST000004434621826120_160829.01201.0RepeatNote=WD 3
TgeneSEC31Achr2:9634765chr4:83765662ENST000004434621826166_206829.01201.0RepeatNote=WD 4
TgeneSEC31Achr2:9634765chr4:83765662ENST000004434621826209_254829.01201.0RepeatNote=WD 5
TgeneSEC31Achr2:9634765chr4:83765662ENST000004434621826258_298829.01201.0RepeatNote=WD 6
TgeneSEC31Achr2:9634765chr4:83765662ENST000004434621826301_342829.01201.0RepeatNote=WD 7
TgeneSEC31Achr2:9634765chr4:83765662ENST0000044346218264_47829.01201.0RepeatNote=WD 1
TgeneSEC31Achr2:9634765chr4:83765662ENST00000443462182668_111829.01201.0RepeatNote=WD 2
TgeneSEC31Achr2:9634765chr4:83765662ENST000004483231927120_160834.01221.0RepeatNote=WD 3
TgeneSEC31Achr2:9634765chr4:83765662ENST000004483231927166_206834.01221.0RepeatNote=WD 4
TgeneSEC31Achr2:9634765chr4:83765662ENST000004483231927209_254834.01221.0RepeatNote=WD 5
TgeneSEC31Achr2:9634765chr4:83765662ENST000004483231927258_298834.01221.0RepeatNote=WD 6
TgeneSEC31Achr2:9634765chr4:83765662ENST000004483231927301_342834.01221.0RepeatNote=WD 7
TgeneSEC31Achr2:9634765chr4:83765662ENST0000044832319274_47834.01221.0RepeatNote=WD 1
TgeneSEC31Achr2:9634765chr4:83765662ENST00000448323192768_111834.01221.0RepeatNote=WD 2
TgeneSEC31Achr2:9634765chr4:83765662ENST000005007771623120_160795.01068.0RepeatNote=WD 3
TgeneSEC31Achr2:9634765chr4:83765662ENST000005007771623166_206795.01068.0RepeatNote=WD 4
TgeneSEC31Achr2:9634765chr4:83765662ENST000005007771623209_254795.01068.0RepeatNote=WD 5
TgeneSEC31Achr2:9634765chr4:83765662ENST000005007771623258_298795.01068.0RepeatNote=WD 6
TgeneSEC31Achr2:9634765chr4:83765662ENST000005007771623301_342795.01068.0RepeatNote=WD 7
TgeneSEC31Achr2:9634765chr4:83765662ENST0000050077716234_47795.01068.0RepeatNote=WD 1
TgeneSEC31Achr2:9634765chr4:83765662ENST00000500777162368_111795.01068.0RepeatNote=WD 2
TgeneSEC31Achr2:9634765chr4:83765662ENST000005085021927120_160834.01206.0RepeatNote=WD 3
TgeneSEC31Achr2:9634765chr4:83765662ENST000005085021927166_206834.01206.0RepeatNote=WD 4
TgeneSEC31Achr2:9634765chr4:83765662ENST000005085021927209_254834.01206.0RepeatNote=WD 5
TgeneSEC31Achr2:9634765chr4:83765662ENST000005085021927258_298834.01206.0RepeatNote=WD 6
TgeneSEC31Achr2:9634765chr4:83765662ENST000005085021927301_342834.01206.0RepeatNote=WD 7
TgeneSEC31Achr2:9634765chr4:83765662ENST0000050850219274_47834.01206.0RepeatNote=WD 1
TgeneSEC31Achr2:9634765chr4:83765662ENST00000508502192768_111834.01206.0RepeatNote=WD 2
TgeneSEC31Achr2:9634765chr4:83765662ENST000005091421926120_160834.01107.0RepeatNote=WD 3
TgeneSEC31Achr2:9634765chr4:83765662ENST000005091421926166_206834.01107.0RepeatNote=WD 4
TgeneSEC31Achr2:9634765chr4:83765662ENST000005091421926209_254834.01107.0RepeatNote=WD 5
TgeneSEC31Achr2:9634765chr4:83765662ENST000005091421926258_298834.01107.0RepeatNote=WD 6
TgeneSEC31Achr2:9634765chr4:83765662ENST000005091421926301_342834.01107.0RepeatNote=WD 7
TgeneSEC31Achr2:9634765chr4:83765662ENST0000050914219264_47834.01107.0RepeatNote=WD 1
TgeneSEC31Achr2:9634765chr4:83765662ENST00000509142192668_111834.01107.0RepeatNote=WD 2
TgeneSEC31Achr2:9634765chr4:83765662ENST000005138581724120_160795.01068.0RepeatNote=WD 3
TgeneSEC31Achr2:9634765chr4:83765662ENST000005138581724166_206795.01068.0RepeatNote=WD 4
TgeneSEC31Achr2:9634765chr4:83765662ENST000005138581724209_254795.01068.0RepeatNote=WD 5
TgeneSEC31Achr2:9634765chr4:83765662ENST000005138581724258_298795.01068.0RepeatNote=WD 6
TgeneSEC31Achr2:9634765chr4:83765662ENST000005138581724301_342795.01068.0RepeatNote=WD 7
TgeneSEC31Achr2:9634765chr4:83765662ENST0000051385817244_47795.01068.0RepeatNote=WD 1
TgeneSEC31Achr2:9634765chr4:83765662ENST00000513858172468_111795.01068.0RepeatNote=WD 2


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Fusion Gene Sequence for ADAM17-SEC31A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000310823_ENST00000348405_TCGA-VR-A8EU_ADAM17_chr2_9634765_-_SEC31A_chr4_83765662_length(transcript)=3671nt_BP=2097nt
ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG
CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG
AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC
CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT
CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT
TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG
GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA
GAGCCACTTTGGAGATTTGTTAATGATACCAAAGACAAAAGAATGTTAGTTTATAAATCTGAAGATATCAAGAATGTTTCACGTTTGCAG
TCTCCAAAAGTGTGTGGTTATTTAAAAGTGGATAATGAAGAGTTGCTCCCAAAAGGGTTAGTAGACAGAGAACCACCTGAAGAGCTTGTT
CATCGAGTGAAAAGAAGAGCTGACCCAGATCCCATGAAGAACACGTGTAAATTATTGGTGGTAGCAGATCATCGCTTCTACAGATACATG
GGCAGAGGGGAAGAGAGTACAACTACAAATTACTTAATAGAGCTAATTGACAGAGTTGATGACATCTATCGGAACACTTCATGGGATAAT
GCAGGTTTTAAAGGCTATGGAATACAGATAGAGCAGATTCGCATTCTCAAGTCTCCACAAGAGGTAAAACCTGGTGAAAAGCACTACAAC
ATGGCAAAAAGTTACCCAAATGAAGAAAAGGATGCTTGGGATGTGAAGATGTTGCTAGAGCAATTTAGCTTTGATATAGCTGAGGAAGCA
TCTAAAGTTTGCTTGGCACACCTTTTCACATACCAAGATTTTGATATGGGAACTCTTGGATTAGCTTATGTTGGCTCTCCCAGAGCAAAC
AGCCATGGAGGTGTTTGTCCAAAGGCTTATTATAGCCCAGTTGGGAAGAAAAATATCTATTTGAATAGTGGTTTGACGAGCACAAAGAAT
TATGGTAAAACCATCCTTACAAAGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT
CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG
TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG
AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG
GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT
GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT
CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC
TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC
TGTACAGTAGGATTTTGTGACATGAATGGAGAAAATCCTCCACCTCCGGGTTTCATAATGCATGGAAATGTTAATCCAAATGCTGCTGGT
CAGCTTCCCACATCTCCAGGTCATATGCACACCCAGGTACCACCTTATCCACAGCCACAGCCTTATCAACCAGCCCAGCCGTATCCCTTC
GGAACAGGGGGGTCAGCAATGTATCGACCTCAGCAGCCTGTTGCTCCTCCTACTTCAAACGCTTACCCTAACACCCCTTACATATCTTCT
GCTTCTTCCTATACTGGGCAGTCTCAGCTGTACGCAGCACAGCACCAGGCCTCTTCACCTACCTCCAGCCCTGCTACTTCTTTCCCTCCT
CCCCCTTCCTCTGGAGCATCCTTCCAGCATGGCGGACCAGGAGCTCCACCATCATCTTCAGCTTATGCACTGCCTCCTGGAACAACAGGT
ACACTGCCTGCTGCCAGTGAGCTGCCTGCGTCCCAAAGAACAGGTCCTCAGAATGGTTGGAATGACCCTCCAGCTTTGAACAGAGTACCC
AAAAAGAAGAAGATGCCTGAAAACTTCATGCCTCCTGTTCCCATCACATCACCAATCATGAACCCGTTGGGTGACCCCCAGTCACAAATG
CTGCAGCAACAGCCTTCAGCTCCAGTACCACTGTCAAGCCAGTCTTCATTCCCACAGCCACATCTTCCAGGTGGCCAGCCCTTCCATGGC
GTACAGCAACCTCTTGGTCAAACAGGCATGCCACCATCTTTTTCAAAGCCCAATATTGAAGGTGCCCCAGGGGCTCCTATTGGAAATACC
TTCCAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACCAAGAAACCTATTCCAGATGAGCACCTCATTCTAAAGACCACATTTGAGGAT
CTTATTCAGCGCTGCCTTTCTTCAGCAACAGACCCTCAAACCAAGAGGAAGCTAGATGATGCCAGCAAACGTTTGGAGTTTCTGTATGAT
AAACTTAGGGAACAGACACTTTCACCAACAATCACCAGTGGTTTACACAACATTGCAAGGAGCATTGAAACTCGAAACTACTCAGAAGGA
TTGACCATGCATACCCACATAGTTAGCACCAGCAACTTCAGTGAGACCTCTGCTTTCATGCCAGTTCTCAAAGTTGTTCTCACCCAGGCC
AATAAGCTGGGTGTCTAAAAGGACAGCTTCTCTTCCACTCAATATTGCCATTTTTCCAAAGAAACATGTTAAAAAAAAAAATTATAAGAC
ATGGACTAGTCCTCATTAGCATGTTTGCATAGCAACCAGTCAAGAGCATTTACACTATTTCTGCTGATATACTCACCTTAGAACTGCTCA
GAACCCTGGTGCTTTATTTTTGTTTTAATCTTTTGTTGCCAGTGATGATTTTCCTATTCTGCAAATAGTGTATTTCCTGGATTACACATA
GTATGGTTTCCTGAAGTATTCTGATAAATGTGTTTTTTAAAACCTCAATATACTTTTTAGAAAAGGAGCATCTGGTTATGCATAAAGCAG

>In-frame_ENST00000310823_ENST00000348405_TCGA-VR-A8EU_ADAM17_chr2_9634765_-_SEC31A_chr4_83765662_length(amino acids)=1024AA_start in transcript=183_stop in transcript=3257
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC
TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA
SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGTLPAASELPASQRTGPQNGWNDPPALNRVPK
KKKMPENFMPPVPITSPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTF
QHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGL

--------------------------------------------------------------
>In-frame_ENST00000310823_ENST00000513858_TCGA-VR-A8EU_ADAM17_chr2_9634765_-_SEC31A_chr4_83765662_length(transcript)=3329nt_BP=2097nt
ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG
CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG
AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC
CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT
CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT
TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG
GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA
GAGCCACTTTGGAGATTTGTTAATGATACCAAAGACAAAAGAATGTTAGTTTATAAATCTGAAGATATCAAGAATGTTTCACGTTTGCAG
TCTCCAAAAGTGTGTGGTTATTTAAAAGTGGATAATGAAGAGTTGCTCCCAAAAGGGTTAGTAGACAGAGAACCACCTGAAGAGCTTGTT
CATCGAGTGAAAAGAAGAGCTGACCCAGATCCCATGAAGAACACGTGTAAATTATTGGTGGTAGCAGATCATCGCTTCTACAGATACATG
GGCAGAGGGGAAGAGAGTACAACTACAAATTACTTAATAGAGCTAATTGACAGAGTTGATGACATCTATCGGAACACTTCATGGGATAAT
GCAGGTTTTAAAGGCTATGGAATACAGATAGAGCAGATTCGCATTCTCAAGTCTCCACAAGAGGTAAAACCTGGTGAAAAGCACTACAAC
ATGGCAAAAAGTTACCCAAATGAAGAAAAGGATGCTTGGGATGTGAAGATGTTGCTAGAGCAATTTAGCTTTGATATAGCTGAGGAAGCA
TCTAAAGTTTGCTTGGCACACCTTTTCACATACCAAGATTTTGATATGGGAACTCTTGGATTAGCTTATGTTGGCTCTCCCAGAGCAAAC
AGCCATGGAGGTGTTTGTCCAAAGGCTTATTATAGCCCAGTTGGGAAGAAAAATATCTATTTGAATAGTGGTTTGACGAGCACAAAGAAT
TATGGTAAAACCATCCTTACAAAGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT
CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG
TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG
AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG
GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT
GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT
CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC
TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC
TGTACAGTAGGATTTTGTGACATGAATGGAGAAAATCCTCCACCTCCGGGTTTCATAATGCATGGAAATGTTAATCCAAATGCTGCTGGT
CAGCTTCCCACATCTCCAGGTCATATGCACACCCAGGTACCACCTTATCCACAGCCACAGCGTCCTCAGAATGGTTGGAATGACCCTCCA
GCTTTGAACAGAGTACCCAAAAAGAAGAAGATGCCTGAAAACTTCATGCCTCCTGTTCCCATCACATCACCAATCATGAACCCGTTGGGT
GACCCCCAGTCACAAATGCTGCAGCAACAGCCTTCAGCTCCAGTACCACTGTCAAGCCAGTCTTCATTCCCACAGCCACATCTTCCAGGT
GGCCAGCCCTTCCATGGCGTACAGCAACCTCTTGGTCAAACAGGCATGCCACCATCTTTTTCAAAGCCCAATATTGAAGGTGCCCCAGGG
GCTCCTATTGGAAATACCTTCCAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACCAAGAAACCTATTCCAGATGAGCACCTCATTCTA
AAGACCACATTTGAGGATCTTATTCAGCGCTGCCTTTCTTCAGCAACAGACCCTCAAACCAAGAGGAAGCTAGATGATGCCAGCAAACGT
TTGGAGTTTCTGTATGATAAACTTAGGGAACAGACACTTTCACCAACAATCACCAGTGGTTTACACAACATTGCAAGGAGCATTGAAACT
CGAAACTACTCAGAAGGATTGACCATGCATACCCACATAGTTAGCACCAGCAACTTCAGTGAGACCTCTGCTTTCATGCCAGTTCTCAAA
GTTGTTCTCACCCAGGCCAATAAGCTGGGTGTCTAAAAGGACAGCTTCTCTTCCACTCAATATTGCCATTTTTCCAAAGAAACATGTTAA
AAAAAAAAATTATAAGACATGGACTAGTCCTCATTAGCATGTTTGCATAGCAACCAGTCAAGAGCATTTACACTATTTCTGCTGATATAC
TCACCTTAGAACTGCTCAGAACCCTGGTGCTTTATTTTTGTTTTAATCTTTTGTTGCCAGTGATGATTTTCCTATTCTGCAAATAGTGTA
TTTCCTGGATTACACATAGTATGGTTTCCTGAAGTATTCTGATAAATGTGTTTTTTAAAACCTCAATATACTTTTTAGAAAAGGAGCATC

>In-frame_ENST00000310823_ENST00000513858_TCGA-VR-A8EU_ADAM17_chr2_9634765_-_SEC31A_chr4_83765662_length(amino acids)=910AA_start in transcript=183_stop in transcript=2915
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC
TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQRPQNGWNDPPALNRVPKKKKMPENFMPPVPITSPIMNPLGD
PQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKPIPDEHLILK
TTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSETSAFMPVLKV

--------------------------------------------------------------
>In-frame_ENST00000310823_ENST00000395310_TCGA-VR-A8EU_ADAM17_chr2_9634765_-_SEC31A_chr4_83765662_length(transcript)=3671nt_BP=2097nt
ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG
CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG
AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC
CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT
CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT
TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG
GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA
GAGCCACTTTGGAGATTTGTTAATGATACCAAAGACAAAAGAATGTTAGTTTATAAATCTGAAGATATCAAGAATGTTTCACGTTTGCAG
TCTCCAAAAGTGTGTGGTTATTTAAAAGTGGATAATGAAGAGTTGCTCCCAAAAGGGTTAGTAGACAGAGAACCACCTGAAGAGCTTGTT
CATCGAGTGAAAAGAAGAGCTGACCCAGATCCCATGAAGAACACGTGTAAATTATTGGTGGTAGCAGATCATCGCTTCTACAGATACATG
GGCAGAGGGGAAGAGAGTACAACTACAAATTACTTAATAGAGCTAATTGACAGAGTTGATGACATCTATCGGAACACTTCATGGGATAAT
GCAGGTTTTAAAGGCTATGGAATACAGATAGAGCAGATTCGCATTCTCAAGTCTCCACAAGAGGTAAAACCTGGTGAAAAGCACTACAAC
ATGGCAAAAAGTTACCCAAATGAAGAAAAGGATGCTTGGGATGTGAAGATGTTGCTAGAGCAATTTAGCTTTGATATAGCTGAGGAAGCA
TCTAAAGTTTGCTTGGCACACCTTTTCACATACCAAGATTTTGATATGGGAACTCTTGGATTAGCTTATGTTGGCTCTCCCAGAGCAAAC
AGCCATGGAGGTGTTTGTCCAAAGGCTTATTATAGCCCAGTTGGGAAGAAAAATATCTATTTGAATAGTGGTTTGACGAGCACAAAGAAT
TATGGTAAAACCATCCTTACAAAGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT
CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG
TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG
AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG
GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT
GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT
CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC
TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC
TGTACAGTAGGATTTTGTGACATGAATGGAGAAAATCCTCCACCTCCGGGTTTCATAATGCATGGAAATGTTAATCCAAATGCTGCTGGT
CAGCTTCCCACATCTCCAGGTCATATGCACACCCAGGTACCACCTTATCCACAGCCACAGCCTTATCAACCAGCCCAGCCGTATCCCTTC
GGAACAGGGGGGTCAGCAATGTATCGACCTCAGCAGCCTGTTGCTCCTCCTACTTCAAACGCTTACCCTAACACCCCTTACATATCTTCT
GCTTCTTCCTATACTGGGCAGTCTCAGCTGTACGCAGCACAGCACCAGGCCTCTTCACCTACCTCCAGCCCTGCTACTTCTTTCCCTCCT
CCCCCTTCCTCTGGAGCATCCTTCCAGCATGGCGGACCAGGAGCTCCACCATCATCTTCAGCTTATGCACTGCCTCCTGGAACAACAGGT
ACACTGCCTGCTGCCAGTGAGCTGCCTGCGTCCCAAAGAACAGGTCCTCAGAATGGTTGGAATGACCCTCCAGCTTTGAACAGAGTACCC
AAAAAGAAGAAGATGCCTGAAAACTTCATGCCTCCTGTTCCCATCACATCACCAATCATGAACCCGTTGGGTGACCCCCAGTCACAAATG
CTGCAGCAACAGCCTTCAGCTCCAGTACCACTGTCAAGCCAGTCTTCATTCCCACAGCCACATCTTCCAGGTGGCCAGCCCTTCCATGGC
GTACAGCAACCTCTTGGTCAAACAGGCATGCCACCATCTTTTTCAAAGCCCAATATTGAAGGTGCCCCAGGGGCTCCTATTGGAAATACC
TTCCAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACCAAGAAACCTATTCCAGATGAGCACCTCATTCTAAAGACCACATTTGAGGAT
CTTATTCAGCGCTGCCTTTCTTCAGCAACAGACCCTCAAACCAAGAGGAAGCTAGATGATGCCAGCAAACGTTTGGAGTTTCTGTATGAT
AAACTTAGGGAACAGACACTTTCACCAACAATCACCAGTGGTTTACACAACATTGCAAGGAGCATTGAAACTCGAAACTACTCAGAAGGA
TTGACCATGCATACCCACATAGTTAGCACCAGCAACTTCAGTGAGACCTCTGCTTTCATGCCAGTTCTCAAAGTTGTTCTCACCCAGGCC
AATAAGCTGGGTGTCTAAAAGGACAGCTTCTCTTCCACTCAATATTGCCATTTTTCCAAAGAAACATGTTAAAAAAAAAAATTATAAGAC
ATGGACTAGTCCTCATTAGCATGTTTGCATAGCAACCAGTCAAGAGCATTTACACTATTTCTGCTGATATACTCACCTTAGAACTGCTCA
GAACCCTGGTGCTTTATTTTTGTTTTAATCTTTTGTTGCCAGTGATGATTTTCCTATTCTGCAAATAGTGTATTTCCTGGATTACACATA
GTATGGTTTCCTGAAGTATTCTGATAAATGTGTTTTTTAAAACCTCAATATACTTTTTAGAAAAGGAGCATCTGGTTATGCATAAAGCAG

>In-frame_ENST00000310823_ENST00000395310_TCGA-VR-A8EU_ADAM17_chr2_9634765_-_SEC31A_chr4_83765662_length(amino acids)=1024AA_start in transcript=183_stop in transcript=3257
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC
TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA
SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGTLPAASELPASQRTGPQNGWNDPPALNRVPK
KKKMPENFMPPVPITSPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTF
QHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGL

--------------------------------------------------------------
>In-frame_ENST00000310823_ENST00000443462_TCGA-VR-A8EU_ADAM17_chr2_9634765_-_SEC31A_chr4_83765662_length(transcript)=3625nt_BP=2097nt
ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG
CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG
AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC
CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT
CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT
TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG
GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA
GAGCCACTTTGGAGATTTGTTAATGATACCAAAGACAAAAGAATGTTAGTTTATAAATCTGAAGATATCAAGAATGTTTCACGTTTGCAG
TCTCCAAAAGTGTGTGGTTATTTAAAAGTGGATAATGAAGAGTTGCTCCCAAAAGGGTTAGTAGACAGAGAACCACCTGAAGAGCTTGTT
CATCGAGTGAAAAGAAGAGCTGACCCAGATCCCATGAAGAACACGTGTAAATTATTGGTGGTAGCAGATCATCGCTTCTACAGATACATG
GGCAGAGGGGAAGAGAGTACAACTACAAATTACTTAATAGAGCTAATTGACAGAGTTGATGACATCTATCGGAACACTTCATGGGATAAT
GCAGGTTTTAAAGGCTATGGAATACAGATAGAGCAGATTCGCATTCTCAAGTCTCCACAAGAGGTAAAACCTGGTGAAAAGCACTACAAC
ATGGCAAAAAGTTACCCAAATGAAGAAAAGGATGCTTGGGATGTGAAGATGTTGCTAGAGCAATTTAGCTTTGATATAGCTGAGGAAGCA
TCTAAAGTTTGCTTGGCACACCTTTTCACATACCAAGATTTTGATATGGGAACTCTTGGATTAGCTTATGTTGGCTCTCCCAGAGCAAAC
AGCCATGGAGGTGTTTGTCCAAAGGCTTATTATAGCCCAGTTGGGAAGAAAAATATCTATTTGAATAGTGGTTTGACGAGCACAAAGAAT
TATGGTAAAACCATCCTTACAAAGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT
CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG
TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG
AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG
GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT
GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT
CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC
TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC
TGTACAGTAGGATTTTGTGACATGAATGGAGAAAATCCTCCACCTCCGGGTTTCATAATGCATGGAAATGTTAATCCAAATGCTGCTGGT
CAGCTTCCCACATCTCCAGGTCATATGCACACCCAGGTACCACCTTATCCACAGCCACAGCCTTATCAACCAGCCCAGCCGTATCCCTTC
GGAACAGGGGGGTCAGCAATGTATCGACCTCAGCAGCCTGTTGCTCCTCCTACTTCAAACGCTTACCCTAACACCCCTTACATATCTTCT
GCTTCTTCCTATACTGGGCAGTCTCAGCTGTACGCAGCACAGCACCAGGCCTCTTCACCTACCTCCAGCCCTGCTACTTCTTTCCCTCCT
CCCCCTTCCTCTGGAGCATCCTTCCAGCATGGCGGACCAGGAGCTCCACCATCATCTTCAGCTTATGCACTGCCTCCTGGAACAACAGGT
CCTCAGAATGGTTGGAATGACCCTCCAGCTTTGAACAGAGTACCCAAAAAGAAGAAGATGCCTGAAAACTTCATGCCTCCTGTTCCCATC
ACATCACCAATCATGAACCCGTTGGGTGACCCCCAGTCACAAATGCTGCAGCAACAGCCTTCAGCTCCAGTACCACTGTCAAGCCAGTCT
TCATTCCCACAGCCACATCTTCCAGGTGGCCAGCCCTTCCATGGCGTACAGCAACCTCTTGGTCAAACAGGCATGCCACCATCTTTTTCA
AAGCCCAATATTGAAGGTGCCCCAGGGGCTCCTATTGGAAATACCTTCCAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACCAAGAAA
CCTATTCCAGATGAGCACCTCATTCTAAAGACCACATTTGAGGATCTTATTCAGCGCTGCCTTTCTTCAGCAACAGACCCTCAAACCAAG
AGGAAGCTAGATGATGCCAGCAAACGTTTGGAGTTTCTGTATGATAAACTTAGGGAACAGACACTTTCACCAACAATCACCAGTGGTTTA
CACAACATTGCAAGGAGCATTGAAACTCGAAACTACTCAGAAGGATTGACCATGCATACCCACATAGTTAGCACCAGCAACTTCAGTGAG
ACCTCTGCTTTCATGCCAGTTCTCAAAGTTGTTCTCACCCAGGCCAATAAGCTGGGTGTCTAAAAGGACAGCTTCTCTTCCACTCAATAT
TGCCATTTTTCCAAAGAAACATGTTAAAAAAAAAAATTATAAGACATGGACTAGTCCTCATTAGCATGTTTGCATAGCAACCAGTCAAGA
GCATTTACACTATTTCTGCTGATATACTCACCTTAGAACTGCTCAGAACCCTGGTGCTTTATTTTTGTTTTAATCTTTTGTTGCCAGTGA
TGATTTTCCTATTCTGCAAATAGTGTATTTCCTGGATTACACATAGTATGGTTTCCTGAAGTATTCTGATAAATGTGTTTTTTAAAACCT
CAATATACTTTTTAGAAAAGGAGCATCTGGTTATGCATAAAGCAGAGCTAAAACTAAATTTCTTTCATGTCCTCCCTACTTCCTCAGTGT

>In-frame_ENST00000310823_ENST00000443462_TCGA-VR-A8EU_ADAM17_chr2_9634765_-_SEC31A_chr4_83765662_length(amino acids)=1009AA_start in transcript=183_stop in transcript=3212
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC
TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA
SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGPQNGWNDPPALNRVPKKKKMPENFMPPVPIT
SPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKP
IPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSET

--------------------------------------------------------------
>In-frame_ENST00000310823_ENST00000509142_TCGA-VR-A8EU_ADAM17_chr2_9634765_-_SEC31A_chr4_83765662_length(transcript)=3328nt_BP=2097nt
ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG
CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG
AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC
CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT
CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT
TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG
GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA
GAGCCACTTTGGAGATTTGTTAATGATACCAAAGACAAAAGAATGTTAGTTTATAAATCTGAAGATATCAAGAATGTTTCACGTTTGCAG
TCTCCAAAAGTGTGTGGTTATTTAAAAGTGGATAATGAAGAGTTGCTCCCAAAAGGGTTAGTAGACAGAGAACCACCTGAAGAGCTTGTT
CATCGAGTGAAAAGAAGAGCTGACCCAGATCCCATGAAGAACACGTGTAAATTATTGGTGGTAGCAGATCATCGCTTCTACAGATACATG
GGCAGAGGGGAAGAGAGTACAACTACAAATTACTTAATAGAGCTAATTGACAGAGTTGATGACATCTATCGGAACACTTCATGGGATAAT
GCAGGTTTTAAAGGCTATGGAATACAGATAGAGCAGATTCGCATTCTCAAGTCTCCACAAGAGGTAAAACCTGGTGAAAAGCACTACAAC
ATGGCAAAAAGTTACCCAAATGAAGAAAAGGATGCTTGGGATGTGAAGATGTTGCTAGAGCAATTTAGCTTTGATATAGCTGAGGAAGCA
TCTAAAGTTTGCTTGGCACACCTTTTCACATACCAAGATTTTGATATGGGAACTCTTGGATTAGCTTATGTTGGCTCTCCCAGAGCAAAC
AGCCATGGAGGTGTTTGTCCAAAGGCTTATTATAGCCCAGTTGGGAAGAAAAATATCTATTTGAATAGTGGTTTGACGAGCACAAAGAAT
TATGGTAAAACCATCCTTACAAAGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT
CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG
TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG
AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG
GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT
GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT
CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC
TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC
TGTACAGTAGGATTTTGTGACATGAATGGAGAAAATCCTCCACCTCCGGGTTTCATAATGCATGGAAATGTTAATCCAAATGCTGCTGGT
CAGCTTCCCACATCTCCAGGTCATATGCACACCCAGGTACCACCTTATCCACAGCCACAGCGTCCTCAGAATGGTTGGAATGACCCTCCA
GCTTTGAACAGAGTACCCAAAAAGAAGAAGATGCCTGAAAACTTCATGCCTCCTGTTCCCATCACATCACCAATCATGAACCCGTTGGGT
GACCCCCAGTCACAAATGCTGCAGCAACAGCCTTCAGCTCCAGTACCACTGTCAAGCCAGTCTTCATTCCCACAGCCACATCTTCCAGGT
GGCCAGCCCTTCCATGGCGTACAGCAACCTCTTGGTCAAACAGGCATGCCACCATCTTTTTCAAAGCCCAATATTGAAGGTGCCCCAGGG
GCTCCTATTGGAAATACCTTCCAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACCAAGAAACCTATTCCAGATGAGCACCTCATTCTA
AAGACCACATTTGAGGATCTTATTCAGCGCTGCCTTTCTTCAGCAACAGACCCTCAAACCAAGAGGAAGCTAGATGATGCCAGCAAACGT
TTGGAGTTTCTGTATGATAAACTTAGGGAACAGACACTTTCACCAACAATCACCAGTGGTTTACACAACATTGCAAGGAGCATTGAAACT
CGAAACTACTCAGAAGGATTGACCATGCATACCCACATAGTTAGCACCAGCAACTTCAGTGAGACCTCTGCTTTCATGCCAGTTCTCAAA
GTTGTTCTCACCCAGGCCAATAAGCTGGGTGTCTAAAAGGACAGCTTCTCTTCCACTCAATATTGCCATTTTTCCAAAGAAACATGTTAA
AAAAAAAAATTATAAGACATGGACTAGTCCTCATTAGCATGTTTGCATAGCAACCAGTCAAGAGCATTTACACTATTTCTGCTGATATAC
TCACCTTAGAACTGCTCAGAACCCTGGTGCTTTATTTTTGTTTTAATCTTTTGTTGCCAGTGATGATTTTCCTATTCTGCAAATAGTGTA
TTTCCTGGATTACACATAGTATGGTTTCCTGAAGTATTCTGATAAATGTGTTTTTTAAAACCTCAATATACTTTTTAGAAAAGGAGCATC

>In-frame_ENST00000310823_ENST00000509142_TCGA-VR-A8EU_ADAM17_chr2_9634765_-_SEC31A_chr4_83765662_length(amino acids)=910AA_start in transcript=183_stop in transcript=2915
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC
TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQRPQNGWNDPPALNRVPKKKKMPENFMPPVPITSPIMNPLGD
PQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKPIPDEHLILK
TTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSETSAFMPVLKV

--------------------------------------------------------------
>In-frame_ENST00000310823_ENST00000326950_TCGA-VR-A8EU_ADAM17_chr2_9634765_-_SEC31A_chr4_83765662_length(transcript)=3670nt_BP=2097nt
ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG
CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG
AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC
CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT
CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT
TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG
GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA
GAGCCACTTTGGAGATTTGTTAATGATACCAAAGACAAAAGAATGTTAGTTTATAAATCTGAAGATATCAAGAATGTTTCACGTTTGCAG
TCTCCAAAAGTGTGTGGTTATTTAAAAGTGGATAATGAAGAGTTGCTCCCAAAAGGGTTAGTAGACAGAGAACCACCTGAAGAGCTTGTT
CATCGAGTGAAAAGAAGAGCTGACCCAGATCCCATGAAGAACACGTGTAAATTATTGGTGGTAGCAGATCATCGCTTCTACAGATACATG
GGCAGAGGGGAAGAGAGTACAACTACAAATTACTTAATAGAGCTAATTGACAGAGTTGATGACATCTATCGGAACACTTCATGGGATAAT
GCAGGTTTTAAAGGCTATGGAATACAGATAGAGCAGATTCGCATTCTCAAGTCTCCACAAGAGGTAAAACCTGGTGAAAAGCACTACAAC
ATGGCAAAAAGTTACCCAAATGAAGAAAAGGATGCTTGGGATGTGAAGATGTTGCTAGAGCAATTTAGCTTTGATATAGCTGAGGAAGCA
TCTAAAGTTTGCTTGGCACACCTTTTCACATACCAAGATTTTGATATGGGAACTCTTGGATTAGCTTATGTTGGCTCTCCCAGAGCAAAC
AGCCATGGAGGTGTTTGTCCAAAGGCTTATTATAGCCCAGTTGGGAAGAAAAATATCTATTTGAATAGTGGTTTGACGAGCACAAAGAAT
TATGGTAAAACCATCCTTACAAAGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT
CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG
TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG
AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG
GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT
GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT
CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC
TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC
TGTACAGTAGGATTTTGTGACATGAATGGAGAAAATCCTCCACCTCCGGGTTTCATAATGCATGGAAATGTTAATCCAAATGCTGCTGGT
CAGCTTCCCACATCTCCAGGTCATATGCACACCCAGGTACCACCTTATCCACAGCCACAGCCTTATCAACCAGCCCAGCCGTATCCCTTC
GGAACAGGGGGGTCAGCAATGTATCGACCTCAGCAGCCTGTTGCTCCTCCTACTTCAAACGCTTACCCTAACACCCCTTACATATCTTCT
GCTTCTTCCTATACTGGGCAGTCTCAGCTGTACGCAGCACAGCACCAGGCCTCTTCACCTACCTCCAGCCCTGCTACTTCTTTCCCTCCT
CCCCCTTCCTCTGGAGCATCCTTCCAGCATGGCGGACCAGGAGCTCCACCATCATCTTCAGCTTATGCACTGCCTCCTGGAACAACAGGT
ACACTGCCTGCTGCCAGTGAGCTGCCTGCGTCCCAAAGAACAGGTCCTCAGAATGGTTGGAATGACCCTCCAGCTTTGAACAGAGTACCC
AAAAAGAAGAAGATGCCTGAAAACTTCATGCCTCCTGTTCCCATCACATCACCAATCATGAACCCGTTGGGTGACCCCCAGTCACAAATG
CTGCAGCAACAGCCTTCAGCTCCAGTACCACTGTCAAGCCAGTCTTCATTCCCACAGCCACATCTTCCAGGTGGCCAGCCCTTCCATGGC
GTACAGCAACCTCTTGGTCAAACAGGCATGCCACCATCTTTTTCAAAGCCCAATATTGAAGGTGCCCCAGGGGCTCCTATTGGAAATACC
TTCCAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACCAAGAAACCTATTCCAGATGAGCACCTCATTCTAAAGACCACATTTGAGGAT
CTTATTCAGCGCTGCCTTTCTTCAGCAACAGACCCTCAAACCAAGAGGAAGCTAGATGATGCCAGCAAACGTTTGGAGTTTCTGTATGAT
AAACTTAGGGAACAGACACTTTCACCAACAATCACCAGTGGTTTACACAACATTGCAAGGAGCATTGAAACTCGAAACTACTCAGAAGGA
TTGACCATGCATACCCACATAGTTAGCACCAGCAACTTCAGTGAGACCTCTGCTTTCATGCCAGTTCTCAAAGTTGTTCTCACCCAGGCC
AATAAGCTGGGTGTCTAAAAGGACAGCTTCTCTTCCACTCAATATTGCCATTTTTCCAAAGAAACATGTTAAAAAAAAAAATTATAAGAC
ATGGACTAGTCCTCATTAGCATGTTTGCATAGCAACCAGTCAAGAGCATTTACACTATTTCTGCTGATATACTCACCTTAGAACTGCTCA
GAACCCTGGTGCTTTATTTTTGTTTTAATCTTTTGTTGCCAGTGATGATTTTCCTATTCTGCAAATAGTGTATTTCCTGGATTACACATA
GTATGGTTTCCTGAAGTATTCTGATAAATGTGTTTTTTAAAACCTCAATATACTTTTTAGAAAAGGAGCATCTGGTTATGCATAAAGCAG

>In-frame_ENST00000310823_ENST00000326950_TCGA-VR-A8EU_ADAM17_chr2_9634765_-_SEC31A_chr4_83765662_length(amino acids)=1024AA_start in transcript=183_stop in transcript=3257
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC
TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA
SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGTLPAASELPASQRTGPQNGWNDPPALNRVPK
KKKMPENFMPPVPITSPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTF
QHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGL

--------------------------------------------------------------
>In-frame_ENST00000310823_ENST00000432794_TCGA-VR-A8EU_ADAM17_chr2_9634765_-_SEC31A_chr4_83765662_length(transcript)=3709nt_BP=2097nt
ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG
CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG
AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC
CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT
CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT
TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG
GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA
GAGCCACTTTGGAGATTTGTTAATGATACCAAAGACAAAAGAATGTTAGTTTATAAATCTGAAGATATCAAGAATGTTTCACGTTTGCAG
TCTCCAAAAGTGTGTGGTTATTTAAAAGTGGATAATGAAGAGTTGCTCCCAAAAGGGTTAGTAGACAGAGAACCACCTGAAGAGCTTGTT
CATCGAGTGAAAAGAAGAGCTGACCCAGATCCCATGAAGAACACGTGTAAATTATTGGTGGTAGCAGATCATCGCTTCTACAGATACATG
GGCAGAGGGGAAGAGAGTACAACTACAAATTACTTAATAGAGCTAATTGACAGAGTTGATGACATCTATCGGAACACTTCATGGGATAAT
GCAGGTTTTAAAGGCTATGGAATACAGATAGAGCAGATTCGCATTCTCAAGTCTCCACAAGAGGTAAAACCTGGTGAAAAGCACTACAAC
ATGGCAAAAAGTTACCCAAATGAAGAAAAGGATGCTTGGGATGTGAAGATGTTGCTAGAGCAATTTAGCTTTGATATAGCTGAGGAAGCA
TCTAAAGTTTGCTTGGCACACCTTTTCACATACCAAGATTTTGATATGGGAACTCTTGGATTAGCTTATGTTGGCTCTCCCAGAGCAAAC
AGCCATGGAGGTGTTTGTCCAAAGGCTTATTATAGCCCAGTTGGGAAGAAAAATATCTATTTGAATAGTGGTTTGACGAGCACAAAGAAT
TATGGTAAAACCATCCTTACAAAGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT
CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG
TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG
AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG
GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT
GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT
CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC
TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC
TGTACAGTAGGATTTTGTGACATGAATGGAGAAAATCCTCCACCTCCGGGTTTCATAATGCATGGAAATGTTAATCCAAATGCTGCTGGT
CAGCTTCCCACATCTCCAGGTCATATGCACACCCAGGTACCACCTTATCCACAGCCACAGCCTTATCAACCAGCCCAGCCGTATCCCTTC
GGAACAGGGGGGTCAGCAATGTATCGACCTCAGCAGCCTGTTGCTCCTCCTACTTCAAACGCTTACCCTAACACCCCTTACATATCTTCT
GCTTCTTCCTATACTGGGCAGTCTCAGCTGTACGCAGCACAGCACCAGGCCTCTTCACCTACCTCCAGCCCTGCTACTTCTTTCCCTCCT
CCCCCTTCCTCTGGAGCATCCTTCCAGCATGGCGGACCAGGAGCTCCACCATCATCTTCAGCTTATGCACTGCCTCCTGGAACAACAGGT
ACACTGCCTGCTGCCAGTGAGCTGCCTGCGTCCCAAAGAACAGAAAACCAGTCTATCCAAGACCAGGCACCTATGTTGGAAGGTCCTCAG
AATGGTTGGAATGACCCTCCAGCTTTGAACAGAGTACCCAAAAAGAAGAAGATGCCTGAAAACTTCATGCCTCCTGTTCCCATCACATCA
CCAATCATGAACCCGTTGGGTGACCCCCAGTCACAAATGCTGCAGCAACAGCCTTCAGCTCCAGTACCACTGTCAAGCCAGTCTTCATTC
CCACAGCCACATCTTCCAGGTGGCCAGCCCTTCCATGGCGTACAGCAACCTCTTGGTCAAACAGGCATGCCACCATCTTTTTCAAAGCCC
AATATTGAAGGTGCCCCAGGGGCTCCTATTGGAAATACCTTCCAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACCAAGAAACCTATT
CCAGATGAGCACCTCATTCTAAAGACCACATTTGAGGATCTTATTCAGCGCTGCCTTTCTTCAGCAACAGACCCTCAAACCAAGAGGAAG
CTAGATGATGCCAGCAAACGTTTGGAGTTTCTGTATGATAAACTTAGGGAACAGACACTTTCACCAACAATCACCAGTGGTTTACACAAC
ATTGCAAGGAGCATTGAAACTCGAAACTACTCAGAAGGATTGACCATGCATACCCACATAGTTAGCACCAGCAACTTCAGTGAGACCTCT
GCTTTCATGCCAGTTCTCAAAGTTGTTCTCACCCAGGCCAATAAGCTGGGTGTCTAAAAGGACAGCTTCTCTTCCACTCAATATTGCCAT
TTTTCCAAAGAAACATGTTAAAAAAAAAAATTATAAGACATGGACTAGTCCTCATTAGCATGTTTGCATAGCAACCAGTCAAGAGCATTT
ACACTATTTCTGCTGATATACTCACCTTAGAACTGCTCAGAACCCTGGTGCTTTATTTTTGTTTTAATCTTTTGTTGCCAGTGATGATTT
TCCTATTCTGCAAATAGTGTATTTCCTGGATTACACATAGTATGGTTTCCTGAAGTATTCTGATAAATGTGTTTTTTAAAACCTCAATAT
ACTTTTTAGAAAAGGAGCATCTGGTTATGCATAAAGCAGAGCTAAAACTAAATTTCTTTCATGTCCTCCCTACTTCCTCAGTGTCAATCA

>In-frame_ENST00000310823_ENST00000432794_TCGA-VR-A8EU_ADAM17_chr2_9634765_-_SEC31A_chr4_83765662_length(amino acids)=1037AA_start in transcript=183_stop in transcript=3296
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC
TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA
SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGTLPAASELPASQRTENQSIQDQAPMLEGPQN
GWNDPPALNRVPKKKKMPENFMPPVPITSPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPN
IEGAPGAPIGNTFQHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNI

--------------------------------------------------------------
>In-frame_ENST00000310823_ENST00000311785_TCGA-VR-A8EU_ADAM17_chr2_9634765_-_SEC31A_chr4_83765662_length(transcript)=3328nt_BP=2097nt
ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG
CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG
AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC
CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT
CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT
TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG
GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA
GAGCCACTTTGGAGATTTGTTAATGATACCAAAGACAAAAGAATGTTAGTTTATAAATCTGAAGATATCAAGAATGTTTCACGTTTGCAG
TCTCCAAAAGTGTGTGGTTATTTAAAAGTGGATAATGAAGAGTTGCTCCCAAAAGGGTTAGTAGACAGAGAACCACCTGAAGAGCTTGTT
CATCGAGTGAAAAGAAGAGCTGACCCAGATCCCATGAAGAACACGTGTAAATTATTGGTGGTAGCAGATCATCGCTTCTACAGATACATG
GGCAGAGGGGAAGAGAGTACAACTACAAATTACTTAATAGAGCTAATTGACAGAGTTGATGACATCTATCGGAACACTTCATGGGATAAT
GCAGGTTTTAAAGGCTATGGAATACAGATAGAGCAGATTCGCATTCTCAAGTCTCCACAAGAGGTAAAACCTGGTGAAAAGCACTACAAC
ATGGCAAAAAGTTACCCAAATGAAGAAAAGGATGCTTGGGATGTGAAGATGTTGCTAGAGCAATTTAGCTTTGATATAGCTGAGGAAGCA
TCTAAAGTTTGCTTGGCACACCTTTTCACATACCAAGATTTTGATATGGGAACTCTTGGATTAGCTTATGTTGGCTCTCCCAGAGCAAAC
AGCCATGGAGGTGTTTGTCCAAAGGCTTATTATAGCCCAGTTGGGAAGAAAAATATCTATTTGAATAGTGGTTTGACGAGCACAAAGAAT
TATGGTAAAACCATCCTTACAAAGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT
CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG
TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG
AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG
GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT
GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT
CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC
TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC
TGTACAGTAGGATTTTGTGACATGAATGGAGAAAATCCTCCACCTCCGGGTTTCATAATGCATGGAAATGTTAATCCAAATGCTGCTGGT
CAGCTTCCCACATCTCCAGGTCATATGCACACCCAGGTACCACCTTATCCACAGCCACAGCGTCCTCAGAATGGTTGGAATGACCCTCCA
GCTTTGAACAGAGTACCCAAAAAGAAGAAGATGCCTGAAAACTTCATGCCTCCTGTTCCCATCACATCACCAATCATGAACCCGTTGGGT
GACCCCCAGTCACAAATGCTGCAGCAACAGCCTTCAGCTCCAGTACCACTGTCAAGCCAGTCTTCATTCCCACAGCCACATCTTCCAGGT
GGCCAGCCCTTCCATGGCGTACAGCAACCTCTTGGTCAAACAGGCATGCCACCATCTTTTTCAAAGCCCAATATTGAAGGTGCCCCAGGG
GCTCCTATTGGAAATACCTTCCAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACCAAGAAACCTATTCCAGATGAGCACCTCATTCTA
AAGACCACATTTGAGGATCTTATTCAGCGCTGCCTTTCTTCAGCAACAGACCCTCAAACCAAGAGGAAGCTAGATGATGCCAGCAAACGT
TTGGAGTTTCTGTATGATAAACTTAGGGAACAGACACTTTCACCAACAATCACCAGTGGTTTACACAACATTGCAAGGAGCATTGAAACT
CGAAACTACTCAGAAGGATTGACCATGCATACCCACATAGTTAGCACCAGCAACTTCAGTGAGACCTCTGCTTTCATGCCAGTTCTCAAA
GTTGTTCTCACCCAGGCCAATAAGCTGGGTGTCTAAAAGGACAGCTTCTCTTCCACTCAATATTGCCATTTTTCCAAAGAAACATGTTAA
AAAAAAAAATTATAAGACATGGACTAGTCCTCATTAGCATGTTTGCATAGCAACCAGTCAAGAGCATTTACACTATTTCTGCTGATATAC
TCACCTTAGAACTGCTCAGAACCCTGGTGCTTTATTTTTGTTTTAATCTTTTGTTGCCAGTGATGATTTTCCTATTCTGCAAATAGTGTA
TTTCCTGGATTACACATAGTATGGTTTCCTGAAGTATTCTGATAAATGTGTTTTTTAAAACCTCAATATACTTTTTAGAAAAGGAGCATC

>In-frame_ENST00000310823_ENST00000311785_TCGA-VR-A8EU_ADAM17_chr2_9634765_-_SEC31A_chr4_83765662_length(amino acids)=910AA_start in transcript=183_stop in transcript=2915
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC
TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQRPQNGWNDPPALNRVPKKKKMPENFMPPVPITSPIMNPLGD
PQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKPIPDEHLILK
TTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSETSAFMPVLKV

--------------------------------------------------------------
>In-frame_ENST00000310823_ENST00000448323_TCGA-VR-A8EU_ADAM17_chr2_9634765_-_SEC31A_chr4_83765662_length(transcript)=3670nt_BP=2097nt
ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG
CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG
AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC
CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT
CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT
TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG
GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA
GAGCCACTTTGGAGATTTGTTAATGATACCAAAGACAAAAGAATGTTAGTTTATAAATCTGAAGATATCAAGAATGTTTCACGTTTGCAG
TCTCCAAAAGTGTGTGGTTATTTAAAAGTGGATAATGAAGAGTTGCTCCCAAAAGGGTTAGTAGACAGAGAACCACCTGAAGAGCTTGTT
CATCGAGTGAAAAGAAGAGCTGACCCAGATCCCATGAAGAACACGTGTAAATTATTGGTGGTAGCAGATCATCGCTTCTACAGATACATG
GGCAGAGGGGAAGAGAGTACAACTACAAATTACTTAATAGAGCTAATTGACAGAGTTGATGACATCTATCGGAACACTTCATGGGATAAT
GCAGGTTTTAAAGGCTATGGAATACAGATAGAGCAGATTCGCATTCTCAAGTCTCCACAAGAGGTAAAACCTGGTGAAAAGCACTACAAC
ATGGCAAAAAGTTACCCAAATGAAGAAAAGGATGCTTGGGATGTGAAGATGTTGCTAGAGCAATTTAGCTTTGATATAGCTGAGGAAGCA
TCTAAAGTTTGCTTGGCACACCTTTTCACATACCAAGATTTTGATATGGGAACTCTTGGATTAGCTTATGTTGGCTCTCCCAGAGCAAAC
AGCCATGGAGGTGTTTGTCCAAAGGCTTATTATAGCCCAGTTGGGAAGAAAAATATCTATTTGAATAGTGGTTTGACGAGCACAAAGAAT
TATGGTAAAACCATCCTTACAAAGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT
CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG
TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG
AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG
GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT
GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT
CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC
TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC
TGTACAGTAGGATTTTGTGACATGAATGGAGAAAATCCTCCACCTCCGGGTTTCATAATGCATGGAAATGTTAATCCAAATGCTGCTGGT
CAGCTTCCCACATCTCCAGGTCATATGCACACCCAGGTACCACCTTATCCACAGCCACAGCCTTATCAACCAGCCCAGCCGTATCCCTTC
GGAACAGGGGGGTCAGCAATGTATCGACCTCAGCAGCCTGTTGCTCCTCCTACTTCAAACGCTTACCCTAACACCCCTTACATATCTTCT
GCTTCTTCCTATACTGGGCAGTCTCAGCTGTACGCAGCACAGCACCAGGCCTCTTCACCTACCTCCAGCCCTGCTACTTCTTTCCCTCCT
CCCCCTTCCTCTGGAGCATCCTTCCAGCATGGCGGACCAGGAGCTCCACCATCATCTTCAGCTTATGCACTGCCTCCTGGAACAACAGGT
ACACTGCCTGCTGCCAGTGAGCTGCCTGCGTCCCAAAGAACAGGTCCTCAGAATGGTTGGAATGACCCTCCAGCTTTGAACAGAGTACCC
AAAAAGAAGAAGATGCCTGAAAACTTCATGCCTCCTGTTCCCATCACATCACCAATCATGAACCCGTTGGGTGACCCCCAGTCACAAATG
CTGCAGCAACAGCCTTCAGCTCCAGTACCACTGTCAAGCCAGTCTTCATTCCCACAGCCACATCTTCCAGGTGGCCAGCCCTTCCATGGC
GTACAGCAACCTCTTGGTCAAACAGGCATGCCACCATCTTTTTCAAAGCCCAATATTGAAGGTGCCCCAGGGGCTCCTATTGGAAATACC
TTCCAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACCAAGAAACCTATTCCAGATGAGCACCTCATTCTAAAGACCACATTTGAGGAT
CTTATTCAGCGCTGCCTTTCTTCAGCAACAGACCCTCAAACCAAGAGGAAGCTAGATGATGCCAGCAAACGTTTGGAGTTTCTGTATGAT
AAACTTAGGGAACAGACACTTTCACCAACAATCACCAGTGGTTTACACAACATTGCAAGGAGCATTGAAACTCGAAACTACTCAGAAGGA
TTGACCATGCATACCCACATAGTTAGCACCAGCAACTTCAGTGAGACCTCTGCTTTCATGCCAGTTCTCAAAGTTGTTCTCACCCAGGCC
AATAAGCTGGGTGTCTAAAAGGACAGCTTCTCTTCCACTCAATATTGCCATTTTTCCAAAGAAACATGTTAAAAAAAAAAATTATAAGAC
ATGGACTAGTCCTCATTAGCATGTTTGCATAGCAACCAGTCAAGAGCATTTACACTATTTCTGCTGATATACTCACCTTAGAACTGCTCA
GAACCCTGGTGCTTTATTTTTGTTTTAATCTTTTGTTGCCAGTGATGATTTTCCTATTCTGCAAATAGTGTATTTCCTGGATTACACATA
GTATGGTTTCCTGAAGTATTCTGATAAATGTGTTTTTTAAAACCTCAATATACTTTTTAGAAAAGGAGCATCTGGTTATGCATAAAGCAG

>In-frame_ENST00000310823_ENST00000448323_TCGA-VR-A8EU_ADAM17_chr2_9634765_-_SEC31A_chr4_83765662_length(amino acids)=1024AA_start in transcript=183_stop in transcript=3257
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC
TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA
SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGTLPAASELPASQRTGPQNGWNDPPALNRVPK
KKKMPENFMPPVPITSPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTF
QHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGL

--------------------------------------------------------------
>In-frame_ENST00000310823_ENST00000505472_TCGA-VR-A8EU_ADAM17_chr2_9634765_-_SEC31A_chr4_83765662_length(transcript)=3660nt_BP=2097nt
ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG
CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG
AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC
CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT
CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT
TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG
GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA
GAGCCACTTTGGAGATTTGTTAATGATACCAAAGACAAAAGAATGTTAGTTTATAAATCTGAAGATATCAAGAATGTTTCACGTTTGCAG
TCTCCAAAAGTGTGTGGTTATTTAAAAGTGGATAATGAAGAGTTGCTCCCAAAAGGGTTAGTAGACAGAGAACCACCTGAAGAGCTTGTT
CATCGAGTGAAAAGAAGAGCTGACCCAGATCCCATGAAGAACACGTGTAAATTATTGGTGGTAGCAGATCATCGCTTCTACAGATACATG
GGCAGAGGGGAAGAGAGTACAACTACAAATTACTTAATAGAGCTAATTGACAGAGTTGATGACATCTATCGGAACACTTCATGGGATAAT
GCAGGTTTTAAAGGCTATGGAATACAGATAGAGCAGATTCGCATTCTCAAGTCTCCACAAGAGGTAAAACCTGGTGAAAAGCACTACAAC
ATGGCAAAAAGTTACCCAAATGAAGAAAAGGATGCTTGGGATGTGAAGATGTTGCTAGAGCAATTTAGCTTTGATATAGCTGAGGAAGCA
TCTAAAGTTTGCTTGGCACACCTTTTCACATACCAAGATTTTGATATGGGAACTCTTGGATTAGCTTATGTTGGCTCTCCCAGAGCAAAC
AGCCATGGAGGTGTTTGTCCAAAGGCTTATTATAGCCCAGTTGGGAAGAAAAATATCTATTTGAATAGTGGTTTGACGAGCACAAAGAAT
TATGGTAAAACCATCCTTACAAAGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT
CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG
TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG
AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG
GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT
GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT
CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC
TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC
TGTACAGTAGGATTTTGTGACATGAATGGAGAAAATCCTCCACCTCCGGGTTTCATAATGCATGGAAATGTTAATCCAAATGCTGCTGGT
CAGCTTCCCACATCTCCAGGTCATATGCACACCCAGGTACCACCTTATCCACAGCCACAGCCTTATCAACCAGCCCAGCCGTATCCCTTC
GGAACAGGGGGGTCAGCAATGTATCGACCTCAGCAGCCTGTTGCTCCTCCTACTTCAAACGCTTACCCTAACACCCCTTACATATCTTCT
GCTTCTTCCTATACTGGGCAGTCTCAGCTGTACGCAGCACAGCACCAGGCCTCTTCACCTACCTCCAGCCCTGCTACTTCTTTCCCTCCT
CCCCCTTCCTCTGGAGCATCCTTCCAGCATGGCGGACCAGGAGCTCCACCATCATCTTCAGCTTATGCACTGCCTCCTGGAACAACAGGT
ACACTGCCTGCTGCCAGTGAGCTGCCTGCGTCCCAAAGAACAGGTCCTCAGAATGGTTGGAATGACCCTCCAGCTTTGAACAGAGTACCC
AAAAAGAAGAAGATGCCTGAAAACTTCATGCCTCCTGTTCCCATCACATCACCAATCATGAACCCGTTGGGTGACCCCCAGTCACAAATG
CTGCAGCAACAGCCTTCAGCTCCAGTACCACTGTCAAGCCAGTCTTCATTCCCACAGCCACATCTTCCAGGTGGCCAGCCCTTCCATGGC
GTACAGCAACCTCTTGGTCAAACAGGCATGCCACCATCTTTTTCAAAGCCCAATATTGAAGGTGCCCCAGGGGCTCCTATTGGAAATACC
TTCCAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACCAAGAAACCTATTCCAGATGAGCACCTCATTCTAAAGACCACATTTGAGGAT
CTTATTCAGCGCTGCCTTTCTTCAGCAACAGACCCTCAAACCAAGAGGAAGCTAGATGATGCCAGCAAACGTTTGGAGTTTCTGTATGAT
AAACTTAGGGAACAGACACTTTCACCAACAATCACCAGTGGTTTACACAACATTGCAAGGAGCATTGAAACTCGAAACTACTCAGAAGGA
TTGACCATGCATACCCACATAGTTAGCACCAGCAACTTCAGTGAGACCTCTGCTTTCATGCCAGTTCTCAAAGTTGTTCTCACCCAGGCC
AATAAGCTGGGTGTCTAAAAGGACAGCTTCTCTTCCACTCAATATTGCCATTTTTCCAAAGAAACATGTTAAAAAAAAAAATTATAAGAC
ATGGACTAGTCCTCATTAGCATGTTTGCATAGCAACCAGTCAAGAGCATTTACACTATTTCTGCTGATATACTCACCTTAGAACTGCTCA
GAACCCTGGTGCTTTATTTTTGTTTTAATCTTTTGTTGCCAGTGATGATTTTCCTATTCTGCAAATAGTGTATTTCCTGGATTACACATA
GTATGGTTTCCTGAAGTATTCTGATAAATGTGTTTTTTAAAACCTCAATATACTTTTTAGAAAAGGAGCATCTGGTTATGCATAAAGCAG

>In-frame_ENST00000310823_ENST00000505472_TCGA-VR-A8EU_ADAM17_chr2_9634765_-_SEC31A_chr4_83765662_length(amino acids)=1024AA_start in transcript=183_stop in transcript=3257
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC
TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA
SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGTLPAASELPASQRTGPQNGWNDPPALNRVPK
KKKMPENFMPPVPITSPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTF
QHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGL

--------------------------------------------------------------
>In-frame_ENST00000310823_ENST00000500777_TCGA-VR-A8EU_ADAM17_chr2_9634765_-_SEC31A_chr4_83765662_length(transcript)=3318nt_BP=2097nt
ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG
CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG
AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC
CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT
CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT
TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG
GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA
GAGCCACTTTGGAGATTTGTTAATGATACCAAAGACAAAAGAATGTTAGTTTATAAATCTGAAGATATCAAGAATGTTTCACGTTTGCAG
TCTCCAAAAGTGTGTGGTTATTTAAAAGTGGATAATGAAGAGTTGCTCCCAAAAGGGTTAGTAGACAGAGAACCACCTGAAGAGCTTGTT
CATCGAGTGAAAAGAAGAGCTGACCCAGATCCCATGAAGAACACGTGTAAATTATTGGTGGTAGCAGATCATCGCTTCTACAGATACATG
GGCAGAGGGGAAGAGAGTACAACTACAAATTACTTAATAGAGCTAATTGACAGAGTTGATGACATCTATCGGAACACTTCATGGGATAAT
GCAGGTTTTAAAGGCTATGGAATACAGATAGAGCAGATTCGCATTCTCAAGTCTCCACAAGAGGTAAAACCTGGTGAAAAGCACTACAAC
ATGGCAAAAAGTTACCCAAATGAAGAAAAGGATGCTTGGGATGTGAAGATGTTGCTAGAGCAATTTAGCTTTGATATAGCTGAGGAAGCA
TCTAAAGTTTGCTTGGCACACCTTTTCACATACCAAGATTTTGATATGGGAACTCTTGGATTAGCTTATGTTGGCTCTCCCAGAGCAAAC
AGCCATGGAGGTGTTTGTCCAAAGGCTTATTATAGCCCAGTTGGGAAGAAAAATATCTATTTGAATAGTGGTTTGACGAGCACAAAGAAT
TATGGTAAAACCATCCTTACAAAGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT
CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG
TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG
AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG
GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT
GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT
CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC
TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC
TGTACAGTAGGATTTTGTGACATGAATGGAGAAAATCCTCCACCTCCGGGTTTCATAATGCATGGAAATGTTAATCCAAATGCTGCTGGT
CAGCTTCCCACATCTCCAGGTCATATGCACACCCAGGTACCACCTTATCCACAGCCACAGCGTCCTCAGAATGGTTGGAATGACCCTCCA
GCTTTGAACAGAGTACCCAAAAAGAAGAAGATGCCTGAAAACTTCATGCCTCCTGTTCCCATCACATCACCAATCATGAACCCGTTGGGT
GACCCCCAGTCACAAATGCTGCAGCAACAGCCTTCAGCTCCAGTACCACTGTCAAGCCAGTCTTCATTCCCACAGCCACATCTTCCAGGT
GGCCAGCCCTTCCATGGCGTACAGCAACCTCTTGGTCAAACAGGCATGCCACCATCTTTTTCAAAGCCCAATATTGAAGGTGCCCCAGGG
GCTCCTATTGGAAATACCTTCCAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACCAAGAAACCTATTCCAGATGAGCACCTCATTCTA
AAGACCACATTTGAGGATCTTATTCAGCGCTGCCTTTCTTCAGCAACAGACCCTCAAACCAAGAGGAAGCTAGATGATGCCAGCAAACGT
TTGGAGTTTCTGTATGATAAACTTAGGGAACAGACACTTTCACCAACAATCACCAGTGGTTTACACAACATTGCAAGGAGCATTGAAACT
CGAAACTACTCAGAAGGATTGACCATGCATACCCACATAGTTAGCACCAGCAACTTCAGTGAGACCTCTGCTTTCATGCCAGTTCTCAAA
GTTGTTCTCACCCAGGCCAATAAGCTGGGTGTCTAAAAGGACAGCTTCTCTTCCACTCAATATTGCCATTTTTCCAAAGAAACATGTTAA
AAAAAAAAATTATAAGACATGGACTAGTCCTCATTAGCATGTTTGCATAGCAACCAGTCAAGAGCATTTACACTATTTCTGCTGATATAC
TCACCTTAGAACTGCTCAGAACCCTGGTGCTTTATTTTTGTTTTAATCTTTTGTTGCCAGTGATGATTTTCCTATTCTGCAAATAGTGTA
TTTCCTGGATTACACATAGTATGGTTTCCTGAAGTATTCTGATAAATGTGTTTTTTAAAACCTCAATATACTTTTTAGAAAAGGAGCATC

>In-frame_ENST00000310823_ENST00000500777_TCGA-VR-A8EU_ADAM17_chr2_9634765_-_SEC31A_chr4_83765662_length(amino acids)=910AA_start in transcript=183_stop in transcript=2915
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC
TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQRPQNGWNDPPALNRVPKKKKMPENFMPPVPITSPIMNPLGD
PQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKPIPDEHLILK
TTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSETSAFMPVLKV

--------------------------------------------------------------
>In-frame_ENST00000310823_ENST00000508502_TCGA-VR-A8EU_ADAM17_chr2_9634765_-_SEC31A_chr4_83765662_length(transcript)=3276nt_BP=2097nt
ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG
CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG
AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC
CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT
CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT
TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG
GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA
GAGCCACTTTGGAGATTTGTTAATGATACCAAAGACAAAAGAATGTTAGTTTATAAATCTGAAGATATCAAGAATGTTTCACGTTTGCAG
TCTCCAAAAGTGTGTGGTTATTTAAAAGTGGATAATGAAGAGTTGCTCCCAAAAGGGTTAGTAGACAGAGAACCACCTGAAGAGCTTGTT
CATCGAGTGAAAAGAAGAGCTGACCCAGATCCCATGAAGAACACGTGTAAATTATTGGTGGTAGCAGATCATCGCTTCTACAGATACATG
GGCAGAGGGGAAGAGAGTACAACTACAAATTACTTAATAGAGCTAATTGACAGAGTTGATGACATCTATCGGAACACTTCATGGGATAAT
GCAGGTTTTAAAGGCTATGGAATACAGATAGAGCAGATTCGCATTCTCAAGTCTCCACAAGAGGTAAAACCTGGTGAAAAGCACTACAAC
ATGGCAAAAAGTTACCCAAATGAAGAAAAGGATGCTTGGGATGTGAAGATGTTGCTAGAGCAATTTAGCTTTGATATAGCTGAGGAAGCA
TCTAAAGTTTGCTTGGCACACCTTTTCACATACCAAGATTTTGATATGGGAACTCTTGGATTAGCTTATGTTGGCTCTCCCAGAGCAAAC
AGCCATGGAGGTGTTTGTCCAAAGGCTTATTATAGCCCAGTTGGGAAGAAAAATATCTATTTGAATAGTGGTTTGACGAGCACAAAGAAT
TATGGTAAAACCATCCTTACAAAGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT
CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG
TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG
AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG
GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT
GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT
CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC
TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC
TGTACAGTAGGATTTTGTGACATGAATGGAGAAAATCCTCCACCTCCGGGTTTCATAATGCATGGAAATGTTAATCCAAATGCTGCTGGT
CAGCTTCCCACATCTCCAGGTCATATGCACACCCAGGTACCACCTTATCCACAGCCACAGCCTTATCAACCAGCCCAGCCGTATCCCTTC
GGAACAGGGGGGTCAGCAATGTATCGACCTCAGCAGCCTGTTGCTCCTCCTACTTCAAACGCTTACCCTAACACCCCTTACATATCTTCT
GCTTCTTCCTATACTGGGCAGTCTCAGCTGTACGCAGCACAGCACCAGGCCTCTTCACCTACCTCCAGCCCTGCTACTTCTTTCCCTCCT
CCCCCTTCCTCTGGAGCATCCTTCCAGCATGGCGGACCAGGAGCTCCACCATCATCTTCAGCTTATGCACTGCCTCCTGGAACAACAGGT
CCTCAGAATGGTTGGAATGACCCTCCAGCTTTGAACAGAGTACCCAAAAAGAAGAAGATGCCTGAAAACTTCATGCCTCCTGTTCCCATC
ACATCACCAATCATGAACCCGTTGGGTGACCCCCAGTCACAAATGCTGCAGCAACAGCCTTCAGCTCCAGTACCACTGTCAAGCCAGTCT
TCATTCCCACAGCCACATCTTCCAGGTGGCCAGCCCTTCCATGGCGTACAGCAACCTCTTGGTCAAACAGGCATGCCACCATCTTTTTCA
AAGCCCAATATTGAAGGTGCCCCAGGGGCTCCTATTGGAAATACCTTCCAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACCAAGAAA
CCTATTCCAGATGAGCACCTCATTCTAAAGACCACATTTGAGGATCTTATTCAGCGCTGCCTTTCTTCAGCAACAGACCCTCAAACCAAG
AGGAAGCTAGATGATGCCAGCAAACGTTTGGAGTTTCTGTATGATAAACTTAGGGAACAGACACTTTCACCAACAATCACCAGTGGTTTA
CACAACATTGCAAGGAGCATTGAAACTCGAAACTACTCAGAAGGATTGACCATGCATACCCACATAGTTAGCACCAGCAACTTCAGTGAG
ACCTCTGCTTTCATGCCAGTTCTCAAAGTTGTTCTCACCCAGGCCAATAAGCTGGGTGTCTAAAAGGACAGCTTCTCTTCCACTCAATAT

>In-frame_ENST00000310823_ENST00000508502_TCGA-VR-A8EU_ADAM17_chr2_9634765_-_SEC31A_chr4_83765662_length(amino acids)=1009AA_start in transcript=183_stop in transcript=3212
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC
TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA
SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGPQNGWNDPPALNRVPKKKKMPENFMPPVPIT
SPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKP
IPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSET

--------------------------------------------------------------
>In-frame_ENST00000310823_ENST00000355196_TCGA-VR-A8EU_ADAM17_chr2_9634765_-_SEC31A_chr4_83765662_length(transcript)=3321nt_BP=2097nt
ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG
CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG
AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC
CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT
CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT
TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG
GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA
GAGCCACTTTGGAGATTTGTTAATGATACCAAAGACAAAAGAATGTTAGTTTATAAATCTGAAGATATCAAGAATGTTTCACGTTTGCAG
TCTCCAAAAGTGTGTGGTTATTTAAAAGTGGATAATGAAGAGTTGCTCCCAAAAGGGTTAGTAGACAGAGAACCACCTGAAGAGCTTGTT
CATCGAGTGAAAAGAAGAGCTGACCCAGATCCCATGAAGAACACGTGTAAATTATTGGTGGTAGCAGATCATCGCTTCTACAGATACATG
GGCAGAGGGGAAGAGAGTACAACTACAAATTACTTAATAGAGCTAATTGACAGAGTTGATGACATCTATCGGAACACTTCATGGGATAAT
GCAGGTTTTAAAGGCTATGGAATACAGATAGAGCAGATTCGCATTCTCAAGTCTCCACAAGAGGTAAAACCTGGTGAAAAGCACTACAAC
ATGGCAAAAAGTTACCCAAATGAAGAAAAGGATGCTTGGGATGTGAAGATGTTGCTAGAGCAATTTAGCTTTGATATAGCTGAGGAAGCA
TCTAAAGTTTGCTTGGCACACCTTTTCACATACCAAGATTTTGATATGGGAACTCTTGGATTAGCTTATGTTGGCTCTCCCAGAGCAAAC
AGCCATGGAGGTGTTTGTCCAAAGGCTTATTATAGCCCAGTTGGGAAGAAAAATATCTATTTGAATAGTGGTTTGACGAGCACAAAGAAT
TATGGTAAAACCATCCTTACAAAGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT
CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG
TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG
AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG
GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT
GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT
CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC
TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC
TGTACAGTAGGATTTTGTGACATGAATGGAGAAAATCCTCCACCTCCGGGTTTCATAATGCATGGAAATGTTAATCCAAATGCTGCTGGT
CAGCTTCCCACATCTCCAGGTCATATGCACACCCAGGTACCACCTTATCCACAGCCACAGCCTTATCAACCAGCCCAGCCGTATCCCTTC
GGAACAGGGGGGTCAGCAATGTATCGACCTCAGCAGCCTGTTGCTCCTCCTACTTCAAACGCTTACCCTAACACCCCTTACATATCTTCT
GCTTCTTCCTATACTGGGCAGTCTCAGCTGTACGCAGCACAGCACCAGGCCTCTTCACCTACCTCCAGCCCTGCTACTTCTTTCCCTCCT
CCCCCTTCCTCTGGAGCATCCTTCCAGCATGGCGGACCAGGAGCTCCACCATCATCTTCAGCTTATGCACTGCCTCCTGGAACAACAGGT
ACACTGCCTGCTGCCAGTGAGCTGCCTGCGTCCCAAAGAACAGGTCCTCAGAATGGTTGGAATGACCCTCCAGCTTTGAACAGAGTACCC
AAAAAGAAGAAGATGCCTGAAAACTTCATGCCTCCTGTTCCCATCACATCACCAATCATGAACCCGTTGGGTGACCCCCAGTCACAAATG
CTGCAGCAACAGCCTTCAGCTCCAGTACCACTGTCAAGCCAGTCTTCATTCCCACAGCCACATCTTCCAGGTGGCCAGCCCTTCCATGGC
GTACAGCAACCTCTTGGTCAAACAGGCATGCCACCATCTTTTTCAAAGCCCAATATTGAAGGTGCCCCAGGGGCTCCTATTGGAAATACC
TTCCAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACCAAGAAACCTATTCCAGATGAGCACCTCATTCTAAAGACCACATTTGAGGAT
CTTATTCAGCGCTGCCTTTCTTCAGCAACAGACCCTCAAACCAAGAGGAAGCTAGATGATGCCAGCAAACGTTTGGAGTTTCTGTATGAT
AAACTTAGGGAACAGACACTTTCACCAACAATCACCAGTGGTTTACACAACATTGCAAGGAGCATTGAAACTCGAAACTACTCAGAAGGA
TTGACCATGCATACCCACATAGTTAGCACCAGCAACTTCAGTGAGACCTCTGCTTTCATGCCAGTTCTCAAAGTTGTTCTCACCCAGGCC

>In-frame_ENST00000310823_ENST00000355196_TCGA-VR-A8EU_ADAM17_chr2_9634765_-_SEC31A_chr4_83765662_length(amino acids)=1024AA_start in transcript=183_stop in transcript=3257
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC
TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA
SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGTLPAASELPASQRTGPQNGWNDPPALNRVPK
KKKMPENFMPPVPITSPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTF
QHVQSLPTKKITKKPIPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGL

--------------------------------------------------------------
>In-frame_ENST00000310823_ENST00000264405_TCGA-VR-A8EU_ADAM17_chr2_9634765_-_SEC31A_chr4_83765662_length(transcript)=3265nt_BP=2097nt
ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG
CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG
AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC
CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT
CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT
TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG
GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA
GAGCCACTTTGGAGATTTGTTAATGATACCAAAGACAAAAGAATGTTAGTTTATAAATCTGAAGATATCAAGAATGTTTCACGTTTGCAG
TCTCCAAAAGTGTGTGGTTATTTAAAAGTGGATAATGAAGAGTTGCTCCCAAAAGGGTTAGTAGACAGAGAACCACCTGAAGAGCTTGTT
CATCGAGTGAAAAGAAGAGCTGACCCAGATCCCATGAAGAACACGTGTAAATTATTGGTGGTAGCAGATCATCGCTTCTACAGATACATG
GGCAGAGGGGAAGAGAGTACAACTACAAATTACTTAATAGAGCTAATTGACAGAGTTGATGACATCTATCGGAACACTTCATGGGATAAT
GCAGGTTTTAAAGGCTATGGAATACAGATAGAGCAGATTCGCATTCTCAAGTCTCCACAAGAGGTAAAACCTGGTGAAAAGCACTACAAC
ATGGCAAAAAGTTACCCAAATGAAGAAAAGGATGCTTGGGATGTGAAGATGTTGCTAGAGCAATTTAGCTTTGATATAGCTGAGGAAGCA
TCTAAAGTTTGCTTGGCACACCTTTTCACATACCAAGATTTTGATATGGGAACTCTTGGATTAGCTTATGTTGGCTCTCCCAGAGCAAAC
AGCCATGGAGGTGTTTGTCCAAAGGCTTATTATAGCCCAGTTGGGAAGAAAAATATCTATTTGAATAGTGGTTTGACGAGCACAAAGAAT
TATGGTAAAACCATCCTTACAAAGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT
CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG
TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG
AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG
GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT
GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT
CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC
TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC
TGTACAGTAGGATTTTGTGACATGAATGGAGAAAATCCTCCACCTCCGGGTTTCATAATGCATGGAAATGTTAATCCAAATGCTGCTGGT
CAGCTTCCCACATCTCCAGGTCATATGCACACCCAGGTACCACCTTATCCACAGCCACAGCCTTATCAACCAGCCCAGCCGTATCCCTTC
GGAACAGGGGGGTCAGCAATGTATCGACCTCAGCAGCCTGTTGCTCCTCCTACTTCAAACGCTTACCCTAACACCCCTTACATATCTTCT
GCTTCTTCCTATACTGGGCAGTCTCAGCTGTACGCAGCACAGCACCAGGCCTCTTCACCTACCTCCAGCCCTGCTACTTCTTTCCCTCCT
CCCCCTTCCTCTGGAGCATCCTTCCAGCATGGCGGACCAGGAGCTCCACCATCATCTTCAGCTTATGCACTGCCTCCTGGAACAACAGGT
CCTCAGAATGGTTGGAATGACCCTCCAGCTTTGAACAGAGTACCCAAAAAGAAGAAGATGCCTGAAAACTTCATGCCTCCTGTTCCCATC
ACATCACCAATCATGAACCCGTTGGGTGACCCCCAGTCACAAATGCTGCAGCAACAGCCTTCAGCTCCAGTACCACTGTCAAGCCAGTCT
TCATTCCCACAGCCACATCTTCCAGGTGGCCAGCCCTTCCATGGCGTACAGCAACCTCTTGGTCAAACAGGCATGCCACCATCTTTTTCA
AAGCCCAATATTGAAGGTGCCCCAGGGGCTCCTATTGGAAATACCTTCCAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACCAAGAAA
CCTATTCCAGATGAGCACCTCATTCTAAAGACCACATTTGAGGATCTTATTCAGCGCTGCCTTTCTTCAGCAACAGACCCTCAAACCAAG
AGGAAGCTAGATGATGCCAGCAAACGTTTGGAGTTTCTGTATGATAAACTTAGGGAACAGACACTTTCACCAACAATCACCAGTGGTTTA
CACAACATTGCAAGGAGCATTGAAACTCGAAACTACTCAGAAGGATTGACCATGCATACCCACATAGTTAGCACCAGCAACTTCAGTGAG
ACCTCTGCTTTCATGCCAGTTCTCAAAGTTGTTCTCACCCAGGCCAATAAGCTGGGTGTCTAAAAGGACAGCTTCTCTTCCACTCAATAT

>In-frame_ENST00000310823_ENST00000264405_TCGA-VR-A8EU_ADAM17_chr2_9634765_-_SEC31A_chr4_83765662_length(amino acids)=1009AA_start in transcript=183_stop in transcript=3212
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC
TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA
SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGPQNGWNDPPALNRVPKKKKMPENFMPPVPIT
SPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKP
IPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSET

--------------------------------------------------------------
>In-frame_ENST00000310823_ENST00000505984_TCGA-VR-A8EU_ADAM17_chr2_9634765_-_SEC31A_chr4_83765662_length(transcript)=3243nt_BP=2097nt
ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG
CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG
AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC
CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT
CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT
TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG
GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA
GAGCCACTTTGGAGATTTGTTAATGATACCAAAGACAAAAGAATGTTAGTTTATAAATCTGAAGATATCAAGAATGTTTCACGTTTGCAG
TCTCCAAAAGTGTGTGGTTATTTAAAAGTGGATAATGAAGAGTTGCTCCCAAAAGGGTTAGTAGACAGAGAACCACCTGAAGAGCTTGTT
CATCGAGTGAAAAGAAGAGCTGACCCAGATCCCATGAAGAACACGTGTAAATTATTGGTGGTAGCAGATCATCGCTTCTACAGATACATG
GGCAGAGGGGAAGAGAGTACAACTACAAATTACTTAATAGAGCTAATTGACAGAGTTGATGACATCTATCGGAACACTTCATGGGATAAT
GCAGGTTTTAAAGGCTATGGAATACAGATAGAGCAGATTCGCATTCTCAAGTCTCCACAAGAGGTAAAACCTGGTGAAAAGCACTACAAC
ATGGCAAAAAGTTACCCAAATGAAGAAAAGGATGCTTGGGATGTGAAGATGTTGCTAGAGCAATTTAGCTTTGATATAGCTGAGGAAGCA
TCTAAAGTTTGCTTGGCACACCTTTTCACATACCAAGATTTTGATATGGGAACTCTTGGATTAGCTTATGTTGGCTCTCCCAGAGCAAAC
AGCCATGGAGGTGTTTGTCCAAAGGCTTATTATAGCCCAGTTGGGAAGAAAAATATCTATTTGAATAGTGGTTTGACGAGCACAAAGAAT
TATGGTAAAACCATCCTTACAAAGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT
CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG
TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG
AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG
GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT
GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT
CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC
TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC
TGTACAGTAGGATTTTGTGACATGAATGGAGAAAATCCTCCACCTCCGGGTTTCATAATGCATGGAAATGTTAATCCAAATGCTGCTGGT
CAGCTTCCCACATCTCCAGGTCATATGCACACCCAGGTACCACCTTATCCACAGCCACAGCCTTATCAACCAGCCCAGCCGTATCCCTTC
GGAACAGGGGGGTCAGCAATGTATCGACCTCAGCAGCCTGTTGCTCCTCCTACTTCAAACGCTTACCCTAACACCCCTTACATATCTTCT
GCTTCTTCCTATACTGGGCAGTCTCAGCTGTACGCAGCACAGCACCAGGCCTCTTCACCTACCTCCAGCCCTGCTACTTCTTTCCCTCCT
CCCCCTTCCTCTGGAGCATCCTTCCAGCATGGCGGACCAGGAGCTCCACCATCATCTTCAGCTTATGCACTGCCTCCTGGAACAACAGGT
CCTCAGAATGGTTGGAATGACCCTCCAGCTTTGAACAGAGTACCCAAAAAGAAGAAGATGCCTGAAAACTTCATGCCTCCTGTTCCCATC
ACATCACCAATCATGAACCCGTTGGGTGACCCCCAGTCACAAATGCTGCAGCAACAGCCTTCAGCTCCAGTACCACTGTCAAGCCAGTCT
TCATTCCCACAGCCACATCTTCCAGGTGGCCAGCCCTTCCATGGCGTACAGCAACCTCTTGGTCAAACAGGCATGCCACCATCTTTTTCA
AAGCCCAATATTGAAGGTGCCCCAGGGGCTCCTATTGGAAATACCTTCCAGCATGTGCAGTCTTTGCCAACAAAAAAAATTACCAAGAAA
CCTATTCCAGATGAGCACCTCATTCTAAAGACCACATTTGAGGATCTTATTCAGCGCTGCCTTTCTTCAGCAACAGACCCTCAAACCAAG
AGGAAGCTAGATGATGCCAGCAAACGTTTGGAGTTTCTGTATGATAAACTTAGGGAACAGACACTTTCACCAACAATCACCAGTGGTTTA
CACAACATTGCAAGGAGCATTGAAACTCGAAACTACTCAGAAGGATTGACCATGCATACCCACATAGTTAGCACCAGCAACTTCAGTGAG
ACCTCTGCTTTCATGCCAGTTCTCAAAGTTGTTCTCACCCAGGCCAATAAGCTGGGTGTCTAAAAGGACAGCTTCTCTTCCACTCAATAT

>In-frame_ENST00000310823_ENST00000505984_TCGA-VR-A8EU_ADAM17_chr2_9634765_-_SEC31A_chr4_83765662_length(amino acids)=1009AA_start in transcript=183_stop in transcript=3212
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC
TVGFCDMNGENPPPPGFIMHGNVNPNAAGQLPTSPGHMHTQVPPYPQPQPYQPAQPYPFGTGGSAMYRPQQPVAPPTSNAYPNTPYISSA
SSYTGQSQLYAAQHQASSPTSSPATSFPPPPSSGASFQHGGPGAPPSSSAYALPPGTTGPQNGWNDPPALNRVPKKKKMPENFMPPVPIT
SPIMNPLGDPQSQMLQQQPSAPVPLSSQSSFPQPHLPGGQPFHGVQQPLGQTGMPPSFSKPNIEGAPGAPIGNTFQHVQSLPTKKITKKP
IPDEHLILKTTFEDLIQRCLSSATDPQTKRKLDDASKRLEFLYDKLREQTLSPTITSGLHNIARSIETRNYSEGLTMHTHIVSTSNFSET

--------------------------------------------------------------
>In-frame_ENST00000310823_ENST00000508479_TCGA-VR-A8EU_ADAM17_chr2_9634765_-_SEC31A_chr4_83765662_length(transcript)=2922nt_BP=2097nt
ACCTGCACTTCTGGGGGCGTCGAGCCTGGCGGTAGAATCTTCCCAGTAGGCGGCGCGGGAGGGAAAAGAGGATTGAGGGGCTAGGCCGGG
CGGATCCCGTCCTCCCCCGATGTGAGCAGTTTTCCGAAACCCCGTCAGGCGAAGGCTGCCCAGAGAGGTGGAGTCGGTAGCGGGGCCGGG
AACATGAGGCAGTCTCTCCTATTCCTGACCAGCGTGGTTCCTTTCGTGCTGGCGCCGCGACCTCCGGATGACCCGGGCTTCGGCCCCCAC
CAGAGACTCGAGAAGCTTGATTCTTTGCTCTCAGACTACGATATTCTCTCTTTATCTAATATCCAGCAGCATTCGGTAAGAAAAAGAGAT
CTACAGACTTCAACACATGTAGAAACACTACTAACTTTTTCAGCTTTGAAAAGGCATTTTAAATTATACCTGACATCAAGTACTGAACGT
TTTTCACAAAATTTCAAGGTCGTGGTGGTGGATGGTAAAAACGAAAGCGAGTACACTGTAAAATGGCAGGACTTCTTCACTGGACACGTG
GTTGGTGAGCCTGACTCTAGGGTTCTAGCCCACATAAGAGATGATGATGTTATAATCAGAATCAACACAGATGGGGCCGAATATAACATA
GAGCCACTTTGGAGATTTGTTAATGATACCAAAGACAAAAGAATGTTAGTTTATAAATCTGAAGATATCAAGAATGTTTCACGTTTGCAG
TCTCCAAAAGTGTGTGGTTATTTAAAAGTGGATAATGAAGAGTTGCTCCCAAAAGGGTTAGTAGACAGAGAACCACCTGAAGAGCTTGTT
CATCGAGTGAAAAGAAGAGCTGACCCAGATCCCATGAAGAACACGTGTAAATTATTGGTGGTAGCAGATCATCGCTTCTACAGATACATG
GGCAGAGGGGAAGAGAGTACAACTACAAATTACTTAATAGAGCTAATTGACAGAGTTGATGACATCTATCGGAACACTTCATGGGATAAT
GCAGGTTTTAAAGGCTATGGAATACAGATAGAGCAGATTCGCATTCTCAAGTCTCCACAAGAGGTAAAACCTGGTGAAAAGCACTACAAC
ATGGCAAAAAGTTACCCAAATGAAGAAAAGGATGCTTGGGATGTGAAGATGTTGCTAGAGCAATTTAGCTTTGATATAGCTGAGGAAGCA
TCTAAAGTTTGCTTGGCACACCTTTTCACATACCAAGATTTTGATATGGGAACTCTTGGATTAGCTTATGTTGGCTCTCCCAGAGCAAAC
AGCCATGGAGGTGTTTGTCCAAAGGCTTATTATAGCCCAGTTGGGAAGAAAAATATCTATTTGAATAGTGGTTTGACGAGCACAAAGAAT
TATGGTAAAACCATCCTTACAAAGGAAGCTGACCTGGTTACAACTCATGAATTGGGACATAATTTTGGAGCAGAACATGATCCGGATGGT
CTAGCAGAATGTGCCCCGAATGAGGACCAGGGAGGGAAATATGTCATGTATCCCATAGCTGTGAGTGGCGATCACGAGAACAATAAGATG
TTTTCAAACTGCAGTAAACAATCAATCTATAAGACCATTGAAAGTAAGGCCCAGGAGTGTTTTCAAGAACGCAGCAATAAAGTTTGTGGG
AACTCGAGGGTGGATGAAGGAGAAGAGTGTGATCCTGGCATCATGTATCTGAACAACGACACCTGCTGCAACAGCGACTGCACGTTGAAG
GAAGGTGTCCAGTGCAGTGACAGGAACAGTCCTTGCTGTAAAAACTGTCAGTTTGAGACTGCCCAGAAGAAGTGCCAGGAGGCGATTAAT
GCTACTTGCAAAGGCGTGTCCTACTGCACAGGTAATAGCAGTGAGTGCCCGCCTCCAGGAAATGCTGAAGATGACACTGTTTGCTTGGAT
CTTGGCAAGTGTAAGGATGGGAAATGCATCCCTTTCTGCGAGAGGGAACAGCAGCTGGAGTCCTGTGCATGTAATGAAACTGACAACTCC
TGCAAGGTGTGCTGCAGGGACCTTTCTGGCCGCTGTGTGCCCTATGTCGATGCTGAACAAAAGAACTTATTTTTGAGGAAAGGAAAGCCC
TGTACAGTAGGATTTTGTGACATGAATGGAGAAAATCCTCCACCTCCGGGTTTCATAATGCATGGAAATGTTAATCCAAATGCTGCTGGT
CAGCTTCCCACATCTCCAGGTCATATGCACACCCAGGTACCACCTTATCCACAGCCACAGCGTAAGTAGTGTGACCCCAAAGTCCTTTCA
GAGCAGTATTTATGATCTAATTTAGTAACTTTACTTTGAAGCCCCAAAGTCATTGTCAAATCAATAAGTAAGAACCATTGTGCATAGGAT
TCCTGAGTCCCTGCTACAAAGAGACATGTTTTTTTAGGAGGTGGCCTGAATCACTATGCTAGGAAGTAGCTCCTTTGTCACACTGTTCAG
AGTAGTTGACTCCTGTTCCTCAGCCATTACTAAGACTTGTTAAAGATAATCAAGTGTCCCATGATTTTGGTATAAAGAAACAGAATTTTA
GAAATTATTTTTTACATATTCTTTTTCTTCAGGCAAGATGACACAAATTATTTTTGGAAAAATGGTTTCAAGGGGCATTTGTTATTACTG
TTTTTCCATTTTATTTATTTATTTAATAGACTTTGTATTTTAGAGCAGTCTTAGGTTCAGAACAAAATTGAGCAGAAAGTACAGAGTGCC
CCCACTATTGACATCCTACGCCACAGTGGTGTATTTGTTACAATCGATGAACCTACATCAATGTCTCATTATCACCCAAAGTCCACAGTT
TACACTCTCAGTGTTGTACATTCTGTGGATTTTAACAAATGTGTAATGACATGTATCTATTAGTGGCATTTTTAAAAGAAAATAATTATA

>In-frame_ENST00000310823_ENST00000508479_TCGA-VR-A8EU_ADAM17_chr2_9634765_-_SEC31A_chr4_83765662_length(amino acids)=681AA_start in transcript=183_stop in transcript=2228
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERF
SQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMF
SNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPC

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Fusion Gene PPI Analysis for ADAM17-SEC31A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneSEC31Achr2:9634765chr4:83765662ENST000003269501725800_1113795.01182.0PDCD6
TgeneSEC31Achr2:9634765chr4:83765662ENST000003484051725800_1113795.01182.0PDCD6
TgeneSEC31Achr2:9634765chr4:83765662ENST000005007771623800_1113795.01068.0PDCD6
TgeneSEC31Achr2:9634765chr4:83765662ENST000005138581724800_1113795.01068.0PDCD6


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneSEC31Achr2:9634765chr4:83765662ENST000003117851926800_1113834.01107.0PDCD6
TgeneSEC31Achr2:9634765chr4:83765662ENST000003551962129800_1113834.01221.0PDCD6
TgeneSEC31Achr2:9634765chr4:83765662ENST000003953101927800_1113834.01221.0PDCD6
TgeneSEC31Achr2:9634765chr4:83765662ENST000004327941928800_1113834.01234.0PDCD6
TgeneSEC31Achr2:9634765chr4:83765662ENST000004434621826800_1113829.01201.0PDCD6
TgeneSEC31Achr2:9634765chr4:83765662ENST000004483231927800_1113834.01221.0PDCD6
TgeneSEC31Achr2:9634765chr4:83765662ENST000005085021927800_1113834.01206.0PDCD6
TgeneSEC31Achr2:9634765chr4:83765662ENST000005091421926800_1113834.01107.0PDCD6
TgeneSEC31Achr2:9634765chr4:83765662ENST000003117851926161_471834.01107.0SEC13
TgeneSEC31Achr2:9634765chr4:83765662ENST000003269501725161_471795.01182.0SEC13
TgeneSEC31Achr2:9634765chr4:83765662ENST000003484051725161_471795.01182.0SEC13
TgeneSEC31Achr2:9634765chr4:83765662ENST000003551962129161_471834.01221.0SEC13
TgeneSEC31Achr2:9634765chr4:83765662ENST000003953101927161_471834.01221.0SEC13
TgeneSEC31Achr2:9634765chr4:83765662ENST000004327941928161_471834.01234.0SEC13
TgeneSEC31Achr2:9634765chr4:83765662ENST000004434621826161_471829.01201.0SEC13
TgeneSEC31Achr2:9634765chr4:83765662ENST000004483231927161_471834.01221.0SEC13
TgeneSEC31Achr2:9634765chr4:83765662ENST000005007771623161_471795.01068.0SEC13
TgeneSEC31Achr2:9634765chr4:83765662ENST000005085021927161_471834.01206.0SEC13
TgeneSEC31Achr2:9634765chr4:83765662ENST000005091421926161_471834.01107.0SEC13
TgeneSEC31Achr2:9634765chr4:83765662ENST000005138581724161_471795.01068.0SEC13


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADAM17-SEC31A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ADAM17-SEC31A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADAM17C3280501INFLAMMATORY SKIN AND BOWEL DISEASE, NEONATAL, 12CTD_human;GENOMICS_ENGLAND
HgeneADAM17C0005758Bulla1CTD_human
HgeneADAM17C0009319Colitis1CTD_human
HgeneADAM17C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneADAM17C3860213Autoinflammatory disorder1GENOMICS_ENGLAND
HgeneADAM17C4751120Neonatal inflammatory skin and bowel disease1ORPHANET
TgeneSEC31AC0079744Diffuse Large B-Cell Lymphoma1CTD_human