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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADAM28-STAG1 (FusionGDB2 ID:2119)

Fusion Gene Summary for ADAM28-STAG1

check button Fusion gene summary
Fusion gene informationFusion gene name: ADAM28-STAG1
Fusion gene ID: 2119
HgeneTgene
Gene symbol

ADAM28

STAG1

Gene ID

10863

56937

Gene nameADAM metallopeptidase domain 28prostate transmembrane protein, androgen induced 1
SynonymsADAM 28|MDC-L|MDCL|eMDC II|eMDCIISTAG1|TMEPAI
Cytomap

8p21.2

20q13.31

Type of geneprotein-codingprotein-coding
Descriptiondisintegrin and metalloproteinase domain-containing protein 28epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein IIepididymial metalloproteinase-like, disintegrin-like, and cysteine-rich protein IIepididymis secretory sperm protein TMEPAIsolid tumor-associated 1 proteintransmembrane, prostate androgen induced RNA
Modification date2020031320200313
UniProtAcc

Q9UKQ2

.
Ensembl transtripts involved in fusion geneENST00000265769, ENST00000540823, 
ENST00000397649, ENST00000437154, 
ENST00000518516, 		ENST00000383202, 
ENST00000236698, ENST00000434713, 
ENST00000480733, ENST00000536929, 
Fusion gene scores* DoF score2 X 2 X 2=816 X 17 X 8=2176
# samples 223
** MAII scorelog2(2/8*10)=1.32192809488736log2(23/2176*10)=-3.24197279030596
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADAM28 [Title/Abstract] AND STAG1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADAM28(24157590)-STAG1(136117671), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSTAG1

GO:0010991

negative regulation of SMAD protein complex assembly

20129061

TgeneSTAG1

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

24627487

TgeneSTAG1

GO:0060394

negative regulation of pathway-restricted SMAD protein phosphorylation

24627487


check buttonFusion gene breakpoints across ADAM28 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across STAG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-BH-A1EV-11AADAM28chr8

24157590

+STAG1chr3

136117671

-


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Fusion Gene ORF analysis for ADAM28-STAG1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000265769ENST00000383202ADAM28chr8

24157590

+STAG1chr3

136117671

-
In-frameENST00000265769ENST00000236698ADAM28chr8

24157590

+STAG1chr3

136117671

-
In-frameENST00000265769ENST00000434713ADAM28chr8

24157590

+STAG1chr3

136117671

-
5CDS-intronENST00000265769ENST00000480733ADAM28chr8

24157590

+STAG1chr3

136117671

-
5CDS-intronENST00000265769ENST00000536929ADAM28chr8

24157590

+STAG1chr3

136117671

-
5UTR-3CDSENST00000540823ENST00000383202ADAM28chr8

24157590

+STAG1chr3

136117671

-
5UTR-3CDSENST00000540823ENST00000236698ADAM28chr8

24157590

+STAG1chr3

136117671

-
5UTR-3CDSENST00000540823ENST00000434713ADAM28chr8

24157590

+STAG1chr3

136117671

-
5UTR-intronENST00000540823ENST00000480733ADAM28chr8

24157590

+STAG1chr3

136117671

-
5UTR-intronENST00000540823ENST00000536929ADAM28chr8

24157590

+STAG1chr3

136117671

-
5UTR-3CDSENST00000397649ENST00000383202ADAM28chr8

24157590

+STAG1chr3

136117671

-
5UTR-3CDSENST00000397649ENST00000236698ADAM28chr8

24157590

+STAG1chr3

136117671

-
5UTR-3CDSENST00000397649ENST00000434713ADAM28chr8

24157590

+STAG1chr3

136117671

-
5UTR-intronENST00000397649ENST00000480733ADAM28chr8

24157590

+STAG1chr3

136117671

-
5UTR-intronENST00000397649ENST00000536929ADAM28chr8

24157590

+STAG1chr3

136117671

-
In-frameENST00000437154ENST00000383202ADAM28chr8

24157590

+STAG1chr3

136117671

-
In-frameENST00000437154ENST00000236698ADAM28chr8

24157590

+STAG1chr3

136117671

-
In-frameENST00000437154ENST00000434713ADAM28chr8

24157590

+STAG1chr3

136117671

-
5CDS-intronENST00000437154ENST00000480733ADAM28chr8

24157590

+STAG1chr3

136117671

-
5CDS-intronENST00000437154ENST00000536929ADAM28chr8

24157590

+STAG1chr3

136117671

-
intron-3CDSENST00000518516ENST00000383202ADAM28chr8

24157590

+STAG1chr3

136117671

-
intron-3CDSENST00000518516ENST00000236698ADAM28chr8

24157590

+STAG1chr3

136117671

-
intron-3CDSENST00000518516ENST00000434713ADAM28chr8

24157590

+STAG1chr3

136117671

-
intron-intronENST00000518516ENST00000480733ADAM28chr8

24157590

+STAG1chr3

136117671

-
intron-intronENST00000518516ENST00000536929ADAM28chr8

24157590

+STAG1chr3

136117671

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265769ADAM28chr824157590+ENST00000383202STAG1chr3136117671-3860260951840581
ENST00000265769ADAM28chr824157590+ENST00000236698STAG1chr3136117671-3748260951729544
ENST00000265769ADAM28chr824157590+ENST00000434713STAG1chr3136117671-2603260951738547
ENST00000437154ADAM28chr824157590+ENST00000383202STAG1chr3136117671-3789189241769581
ENST00000437154ADAM28chr824157590+ENST00000236698STAG1chr3136117671-3677189241658544
ENST00000437154ADAM28chr824157590+ENST00000434713STAG1chr3136117671-2532189241667547

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265769ENST00000383202ADAM28chr824157590+STAG1chr3136117671-0.0004287660.99957126
ENST00000265769ENST00000236698ADAM28chr824157590+STAG1chr3136117671-0.0002990560.999701
ENST00000265769ENST00000434713ADAM28chr824157590+STAG1chr3136117671-0.0006824330.9993175
ENST00000437154ENST00000383202ADAM28chr824157590+STAG1chr3136117671-0.0003947470.99960524
ENST00000437154ENST00000236698ADAM28chr824157590+STAG1chr3136117671-0.0002763010.99972373
ENST00000437154ENST00000434713ADAM28chr824157590+STAG1chr3136117671-0.0005932350.9994068

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Fusion Genomic Features for ADAM28-STAG1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ADAM28-STAG1


check button Go to

FGviewer for the breakpoints of chr8:24157590-chr3:136117671

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADAM28

Q9UKQ2

.
FUNCTION: May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSTAG1chr8:24157590chr3:136117671ENST0000038320220341065_1070732.01259.0Compositional biasNote=Poly-Ser

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAM28chr8:24157590chr3:136117671ENST00000265769+223494_62850.0776.0Compositional biasNote=Cys-rich
HgeneADAM28chr8:24157590chr3:136117671ENST00000437154+214494_62850.0541.0Compositional biasNote=Cys-rich
HgeneADAM28chr8:24157590chr3:136117671ENST00000265769+223204_39950.0776.0DomainPeptidase M12B
HgeneADAM28chr8:24157590chr3:136117671ENST00000265769+223407_49350.0776.0DomainDisintegrin
HgeneADAM28chr8:24157590chr3:136117671ENST00000265769+223625_65750.0776.0DomainEGF-like
HgeneADAM28chr8:24157590chr3:136117671ENST00000437154+214204_39950.0541.0DomainPeptidase M12B
HgeneADAM28chr8:24157590chr3:136117671ENST00000437154+214407_49350.0541.0DomainDisintegrin
HgeneADAM28chr8:24157590chr3:136117671ENST00000437154+214625_65750.0541.0DomainEGF-like
HgeneADAM28chr8:24157590chr3:136117671ENST00000265769+223167_17450.0776.0MotifCysteine switch
HgeneADAM28chr8:24157590chr3:136117671ENST00000437154+214167_17450.0541.0MotifCysteine switch
HgeneADAM28chr8:24157590chr3:136117671ENST00000265769+223199_66550.0776.0Topological domainExtracellular
HgeneADAM28chr8:24157590chr3:136117671ENST00000265769+223687_77550.0776.0Topological domainCytoplasmic
HgeneADAM28chr8:24157590chr3:136117671ENST00000437154+214199_66550.0541.0Topological domainExtracellular
HgeneADAM28chr8:24157590chr3:136117671ENST00000437154+214687_77550.0541.0Topological domainCytoplasmic
HgeneADAM28chr8:24157590chr3:136117671ENST00000265769+223666_68650.0776.0TransmembraneHelical
HgeneADAM28chr8:24157590chr3:136117671ENST00000437154+214666_68650.0541.0TransmembraneHelical
TgeneSTAG1chr8:24157590chr3:136117671ENST000003832022034684_687732.01259.0Compositional biasNote=Poly-Asp
TgeneSTAG1chr8:24157590chr3:136117671ENST000003832022034296_381732.01259.0DomainSCD


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Fusion Gene Sequence for ADAM28-STAG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000265769_ENST00000383202_TCGA-BH-A1EV-11A_ADAM28_chr8_24157590_+_STAG1_chr3_136117671_length(transcript)=3860nt_BP=260nt
GAATGAACCAGGGAGTTTCATTCTGTCTCACTGGAGAGGAGGCAGGGACAGACCCAGCAGCACCCACCTGAGCGAGAAGAGCAGACACCG
TGCTCCTGGAATCACCCAGCATGTTGCAAGGTCTCCTGCCAGTCAGTCTCCTCCTCTCTGTTGCAGTAAGTGCTATAAAAGAACTCCCTG
GGGTGAAGAAGTATGAAGTGGTTTATCCTATAAGACTTCATCCACTGCATAAAAGAGAGGCCAAAGAGCCAGAGCAACAGATAGTCGTGC
AAGCACTGCAGTGTTCCCATTATTCGATTCTTTGGCAGTTGGTGAAAATTACTGATGGCTCTCCTTCCAAAGAGGATTTGTTGGTATTGA
GGAAAACGGTGAAATCCTTTTTGGCTGTTTGCCAGCAGTGCCTGTCTAATGTTAATACTCCAGTGAAAGAACAGGCTTTCATGTTACTCT
GTGATCTTCTGATGATTTTCAGCCACCAATTAATGACAGGTGGCAGAGAGGGCCTTCAGCCTTTGGTGTTCAATCCAGATACTGGACTCC
AATCTGAACTCCTCAGTTTTGTGATGGATCACGTTTTTATTGACCAAGACGAGGAGAACCAGAGCATGGAGGGTGATGAAGAAGATGAAG
CTAATAAAATTGAGGCCTTACATAAAAGAAGGAATCTACTTGCTGCTTTCAGCAAACTTATCATTTATGACATTGTTGACATGCATGCAG
CTGCAGACATCTTCAAACACTACATGAAGTATTACAATGACTATGGTGATATTATTAAGGAAACACTGAGTAAAACCAGGCAGATTGATA
AAATTCAGTGTGCCAAGACTCTCATTCTCAGTTTGCAACAGTTATTTAATGAACTTGTTCAAGAGCAAGGTCCCAACCTAGATAGGACAT
CTGCCCATGTCAGTGGCATTAAAGAACTGGCACGTCGCTTTGCCCTTACATTTGGATTGGACCAGATTAAGACACGAGAAGCAGTTGCCA
CACTTCACAAGGATGGCATAGAGTTTGCATTTAAATACCAAAATCAGAAAGGACAAGAGTATCCACCTCCTAATCTGGCTTTTCTTGAAG
TACTAAGTGAATTTTCTTCTAAACTTCTTCGACAGGACAAAAAGACAGTTCATTCATACCTAGAGAAATTCCTTACCGAGCAGATGATGG
AAAGGAGGGAGGATGTATGGCTTCCACTCATCTCCTATAGAAATTCATTAGTCACTGGGGGTGAAGATGATAGAATGTCTGTGAACAGTG
GAAGTAGCAGCAGCAAAACCTCATCAGTAAGGAATAAGAAAGGACGACCTCCACTTCATAAAAAACGAGTAGAAGATGAGAGTCTGGATA
ACACATGGCTAAACAGGACTGACACCATGATTCAGACTCCTGGCCCCCTGCCAGCACCACAACTCACATCCACTGTACTGCGGGAGAACA
GTCGGCCCATGGGAGACCAGATTCAAGAACCTGAGTCTGAACATGGTTCTGAACCAGACTTTTTACACAATCCTCAGATGCAGATCTCTT
GGTTAGGCCAGCCGAAGTTAGAAGACTTAAATCGGAAGGACAGAACAGGAATGAACTACATGAAAGTGAGAACTGGAGTGAGGCATGCTG
TTCGGGGTCTAATGGAGGAAGATGCTGAGCCCATCTTTGAAGATGTGATGATGTCATCCCGAAGCCAGTTAGAAGATATGAATGAAGAAT
TTGAGGACACCATGGTTATTGATCTGCCTCCATCAAGAAATCGGCGAGAGAGAGCTGAGCTAAGGCCAGACTTCTTTGACTCTGCAGCTA
TCATAGAAGATGATTCAGGATTTGGAATGCCTATGTTCTGAAGTCTGAAGAAAATTTACAAATCTGGAACTCTATTATTTAGAGCTAGAG
GCCTATATACTGTGATAGCTTGTATGGGGAAAAACACTTTTGATGTGATCTGATTTGTTTTTTAATCAAATGATTAAGGTCAATCCCTTT
TTGCAGTGACAGAAGAGGAGCATGTAAATTACCCAAGGGAATGTTGGTGAATGTCAACTCAGAAAGACTGACCTGAAAATCATTTGTGTC
CTACTATTGGACTTATCCCAATACAGATGTGTGTGTTTTTCTGGAGGGAGGAAGAAATTTTAAATTTTTAAAACAGCTGTCAAGATAAAC
ACTGTTATACACCTGTTTTATGAAAACTCAACATTGAGTAAAAAAAAACATATTTTTAACTTTATTTTCCTGTTGTACAATTTAAAAACC
GTTTTAACATTTTGCCTTTTTATGTTTTAAAAGCTAACCATTTTTATTAAACCTATGAGTAAGCAGCTCATCCTAATTGCGAAGAGTGTT
TTGGAGTTCACTGGATTTGGTTGACCTTTGTGGAACACAAATAATGAAGGAGCAGAACATTGACAAGCTAAGATGAAATTCTGACATAGT
ACATCTCTGCCAAAAACCACACACCCTCTGTGGATATGGATATGAATTCCCAGATTTTATATACTCTTGAATAAAAGGTTTATTTTTATT
TATAAGTGGGCATAAAATAAGAAATGTCCATGCAGCCATTTTTCCAACAGATGCTGTACACCGTTCATTTTATATAGACTAGGGAGATTC
AAATACAGTGCATTTTCTATTGGTATTTGTTCTGTGCATTTTTAGCAACTTCTACCAGCAAATAAAGTATTCTCAGTAAAACGAAAATGA
TTCTCAAGTTATCAGTTTGCTGTTTTTACCACTTATTTCATGCCCTGCCAAATTCAAGTTACACAGACTTCCATTTTCTTAAGATAATCA
ATCATGAAGAAATCCTTTATCAATCATTCAAAAGTAATTTTAAGTGTAACATAACTGTGTTTACTTCCCATGCACTTAATACCCTTATGC
GCTAATTTTGTGAATTAAGTTTACTGATTATAGAAGTATGTGCTGCATAGAAGTCTGTGCTTAGAGGGTGAAGTTCCTAAGCTTACCTTG
AATTACAGCTACATTTCAGTGTTAAATGTGCATATTAAGAATAATTCTTTTGGGGAAAGAAATTATGAATCTTCAGGACAGTCTACAATG
GTTTAGAGTTACATTCTGCCTAGACTTTTATGACTTGCTGCTATTGTTTTAAAAACCCCACTTAGTCTCTCTCTTCCTTTCTGATTTCTA
AAGTAAGCCTCAGAATTTCCAAACCAATTCATCCACAGCTGTTTCTGGGCTGGTTTTTAAAGTAGCTGCAACAGAATCATGAGGCTTTCC
CTTTTTATCAAATACGAAAAACATTTTTTAAAATTCTGCACACCCAGTGATCATCTTTTGTGCGGGAAAGCAAGATGATGATGGATGATT
TTATTCATCCTTTTAGTAAAGACACAAAACATTTTTCTCAACATTTGTACAGTTCTGAAAAAAACCTGGTCACCAAAAATATCTTCTCTG
CTAATTCAGCAATTCTTGGGCTCCAGTTAGGGGAGCTGGGGCCTCACTTTCTCCCAGAATTGTGGGCTTCACTGGAAGTGAAGGTGCAGG
AATGACTGGACTGTCCACCCCAGCCCTGCCTGCCTGTGGTTTTGGCCAGGGAGCAAGCCATGAGGTGCCCTGGCACATGCACAAATTGAT
CCTTTGCGTGACAGTCTTGTATGGAAAACAGATGCTGACAGAATTGTAGACTACCATGCCACACAAAAAGGCTAAATATCTACTCCAATG
GGTTTCCAGTTCAGTTTGAAGTCAATCAAATTTTTGTATTTTCGGTGTCTCCTTGATTGGTTTTGCTAGTAATTCTGTAAATTGTACATT

>In-frame_ENST00000265769_ENST00000383202_TCGA-BH-A1EV-11A_ADAM28_chr8_24157590_+_STAG1_chr3_136117671_length(amino acids)=581AA_start in transcript=95_stop in transcript=1840
MESPSMLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQIVVQALQCSHYSILWQLVKITDGSPSKEDLLVLRK
TVKSFLAVCQQCLSNVNTPVKEQAFMLLCDLLMIFSHQLMTGGREGLQPLVFNPDTGLQSELLSFVMDHVFIDQDEENQSMEGDEEDEAN
KIEALHKRRNLLAAFSKLIIYDIVDMHAAADIFKHYMKYYNDYGDIIKETLSKTRQIDKIQCAKTLILSLQQLFNELVQEQGPNLDRTSA
HVSGIKELARRFALTFGLDQIKTREAVATLHKDGIEFAFKYQNQKGQEYPPPNLAFLEVLSEFSSKLLRQDKKTVHSYLEKFLTEQMMER
REDVWLPLISYRNSLVTGGEDDRMSVNSGSSSSKTSSVRNKKGRPPLHKKRVEDESLDNTWLNRTDTMIQTPGPLPAPQLTSTVLRENSR
PMGDQIQEPESEHGSEPDFLHNPQMQISWLGQPKLEDLNRKDRTGMNYMKVRTGVRHAVRGLMEEDAEPIFEDVMMSSRSQLEDMNEEFE

--------------------------------------------------------------
>In-frame_ENST00000265769_ENST00000236698_TCGA-BH-A1EV-11A_ADAM28_chr8_24157590_+_STAG1_chr3_136117671_length(transcript)=3748nt_BP=260nt
GAATGAACCAGGGAGTTTCATTCTGTCTCACTGGAGAGGAGGCAGGGACAGACCCAGCAGCACCCACCTGAGCGAGAAGAGCAGACACCG
TGCTCCTGGAATCACCCAGCATGTTGCAAGGTCTCCTGCCAGTCAGTCTCCTCCTCTCTGTTGCAGTAAGTGCTATAAAAGAACTCCCTG
GGGTGAAGAAGTATGAAGTGGTTTATCCTATAAGACTTCATCCACTGCATAAAAGAGAGGCCAAAGAGCCAGAGCAACAGATAGTCGTGC
AAGCACTGCAGTGTTCCCATTATTCGATTCTTTGGCAGTTGGTGAAAATTACTGATGGCTCTCCTTCCAAAGAGGATTTGTTGGTATTGA
GGAAAACGGTGAAATCCTTTTTGGCTGTTTGCCAGCAGTGCCTGTCTAATGTTAATACTCCAGTGAAAGAACAGGCTTTCATGTTACTCT
GTGATCTTCTGATGATTTTCAGCCACCAATTAATGACAGGTGGCAGAGAGGGCCTTCAGCCTTTGGTGTTCAATCCAGATACTGGACTCC
AATCTGAACTCCTCAGTTTTGTGATGGATCACGTTTTTATTGACCAAGACGAGGAGAACCAGAGCATGGAGGGTGATGAAGAAGATGAAG
CTAATAAAATTGAGGCCTTACATAAAAGAAGGAATCTACTTGCTGCTTTCAGCAAACTTATCATTTATGACATTGTTGACATGCATGCAG
CTGCAGACATCTTCAAACACTACATGAAGTATTACAATGACTATGGTGATATTATTAAGGAAACACTGAGTAAAACCAGGCAGATTGATA
AAATTCAGTGTGCCAAGACTCTCATTCTCAGTTTGCAACAGTTATTTAATGAACTTGTTCAAGAGCAAGGTCCCAACCTAGATAGGACAT
CTGCCCATGTCAGTGGCATTAAAGAACTGGCACGTCGCTTTGCCCTTACATTTGGATTGGACCAGATTAAGACACGAGAAGCAGTTGCCA
CACTTCACAAGGATGGCATAGAGTTTGCATTTAAATACCAAAATCAGAAAGGACAAGAGTATCCACCTCCTAATCTGGCTTTTCTTGAAG
TACTAAGTGAATTTTCTTCTAAACTTCTTCGACAGGACAAAAAGACAGTTCATTCATACCTAGAGAAATTCCTTACCGAGCAGATGATGG
AAAGGAGGGAGGATGTATGGCTTCCACTCATCTCCTATAGAAATTCATTAGTCACTGGGGGTGAAGATGATAGAATGTCTGTGAACAGTG
GAAGTAGCAGCAGCAAAACCTCATCAGTAAGGAATAAGAAAGGACGACCTCCACTTCATAAAAAACGAGTAGAAGATGAGAGTCTGGATA
ACACATGGCTAAACAGGACTGACACCATGATTCAGACTCCTGGCCCCCTGCCAGCACCACAACTCACATCCACTGTACTGCGGGAGAACA
GTCGGCCCATGGGAGACCAGATTCAAGAACCTGAGTCTGAACATGGTTCTGAACCAGACTTTTTACACAATCGGGGTCTAATGGAGGAAG
ATGCTGAGCCCATCTTTGAAGATGTGATGATGTCATCCCGAAGCCAGTTAGAAGATATGAATGAAGAATTTGAGGACACCATGGTTATTG
ATCTGCCTCCATCAAGAAATCGGCGAGAGAGAGCTGAGCTAAGGCCAGACTTCTTTGACTCTGCAGCTATCATAGAAGATGATTCAGGAT
TTGGAATGCCTATGTTCTGAAGTCTGAAGAAAATTTACAAATCTGGAACTCTATTATTTAGAGCTAGAGGCCTATATACTGTGATAGCTT
GTATGGGGAAAAACACTTTTGATGTGATCTGATTTGTTTTTTAATCAAATGATTAAGGTCAATCCCTTTTTGCAGTGACAGAAGAGGAGC
ATGTAAATTACCCAAGGGAATGTTGGTGAATGTCAACTCAGAAAGACTGACCTGAAAATCATTTGTGTCCTACTATTGGACTTATCCCAA
TACAGATGTGTGTGTTTTTCTGGAGGGAGGAAGAAATTTTAAATTTTTAAAACAGCTGTCAAGATAAACACTGTTATACACCTGTTTTAT
GAAAACTCAACATTGAGTAAAAAAAAACATATTTTTAACTTTATTTTCCTGTTGTACAATTTAAAAACCGTTTTAACATTTTGCCTTTTT
ATGTTTTAAAAGCTAACCATTTTTATTAAACCTATGAGTAAGCAGCTCATCCTAATTGCGAAGAGTGTTTTGGAGTTCACTGGATTTGGT
TGACCTTTGTGGAACACAAATAATGAAGGAGCAGAACATTGACAAGCTAAGATGAAATTCTGACATAGTACATCTCTGCCAAAAACCACA
CACCCTCTGTGGATATGGATATGAATTCCCAGATTTTATATACTCTTGAATAAAAGGTTTATTTTTATTTATAAGTGGGCATAAAATAAG
AAATGTCCATGCAGCCATTTTTCCAACAGATGCTGTACACCGTTCATTTTATATAGACTAGGGAGATTCAAATACAGTGCATTTTCTATT
GGTATTTGTTCTGTGCATTTTTAGCAACTTCTACCAGCAAATAAAGTATTCTCAGTAAAACGAAAATGATTCTCAAGTTATCAGTTTGCT
GTTTTTACCACTTATTTCATGCCCTGCCAAATTCAAGTTACACAGACTTCCATTTTCTTAAGATAATCAATCATGAAGAAATCCTTTATC
AATCATTCAAAAGTAATTTTAAGTGTAACATAACTGTGTTTACTTCCCATGCACTTAATACCCTTATGCGCTAATTTTGTGAATTAAGTT
TACTGATTATAGAAGTATGTGCTGCATAGAAGTCTGTGCTTAGAGGGTGAAGTTCCTAAGCTTACCTTGAATTACAGCTACATTTCAGTG
TTAAATGTGCATATTAAGAATAATTCTTTTGGGGAAAGAAATTATGAATCTTCAGGACAGTCTACAATGGTTTAGAGTTACATTCTGCCT
AGACTTTTATGACTTGCTGCTATTGTTTTAAAAACCCCACTTAGTCTCTCTCTTCCTTTCTGATTTCTAAAGTAAGCCTCAGAATTTCCA
AACCAATTCATCCACAGCTGTTTCTGGGCTGGTTTTTAAAGTAGCTGCAACAGAATCATGAGGCTTTCCCTTTTTATCAAATACGAAAAA
CATTTTTTAAAATTCTGCACACCCAGTGATCATCTTTTGTGCGGGAAAGCAAGATGATGATGGATGATTTTATTCATCCTTTTAGTAAAG
ACACAAAACATTTTTCTCAACATTTGTACAGTTCTGAAAAAAACCTGGTCACCAAAAATATCTTCTCTGCTAATTCAGCAATTCTTGGGC
TCCAGTTAGGGGAGCTGGGGCCTCACTTTCTCCCAGAATTGTGGGCTTCACTGGAAGTGAAGGTGCAGGAATGACTGGACTGTCCACCCC
AGCCCTGCCTGCCTGTGGTTTTGGCCAGGGAGCAAGCCATGAGGTGCCCTGGCACATGCACAAATTGATCCTTTGCGTGACAGTCTTGTA
TGGAAAACAGATGCTGACAGAATTGTAGACTACCATGCCACACAAAAAGGCTAAATATCTACTCCAATGGGTTTCCAGTTCAGTTTGAAG
TCAATCAAATTTTTGTATTTTCGGTGTCTCCTTGATTGGTTTTGCTAGTAATTCTGTAAATTGTACATTTGCAATATGAGGTTTTTTTTC

>In-frame_ENST00000265769_ENST00000236698_TCGA-BH-A1EV-11A_ADAM28_chr8_24157590_+_STAG1_chr3_136117671_length(amino acids)=544AA_start in transcript=95_stop in transcript=1729
MESPSMLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQIVVQALQCSHYSILWQLVKITDGSPSKEDLLVLRK
TVKSFLAVCQQCLSNVNTPVKEQAFMLLCDLLMIFSHQLMTGGREGLQPLVFNPDTGLQSELLSFVMDHVFIDQDEENQSMEGDEEDEAN
KIEALHKRRNLLAAFSKLIIYDIVDMHAAADIFKHYMKYYNDYGDIIKETLSKTRQIDKIQCAKTLILSLQQLFNELVQEQGPNLDRTSA
HVSGIKELARRFALTFGLDQIKTREAVATLHKDGIEFAFKYQNQKGQEYPPPNLAFLEVLSEFSSKLLRQDKKTVHSYLEKFLTEQMMER
REDVWLPLISYRNSLVTGGEDDRMSVNSGSSSSKTSSVRNKKGRPPLHKKRVEDESLDNTWLNRTDTMIQTPGPLPAPQLTSTVLRENSR
PMGDQIQEPESEHGSEPDFLHNRGLMEEDAEPIFEDVMMSSRSQLEDMNEEFEDTMVIDLPPSRNRRERAELRPDFFDSAAIIEDDSGFG

--------------------------------------------------------------
>In-frame_ENST00000265769_ENST00000434713_TCGA-BH-A1EV-11A_ADAM28_chr8_24157590_+_STAG1_chr3_136117671_length(transcript)=2603nt_BP=260nt
GAATGAACCAGGGAGTTTCATTCTGTCTCACTGGAGAGGAGGCAGGGACAGACCCAGCAGCACCCACCTGAGCGAGAAGAGCAGACACCG
TGCTCCTGGAATCACCCAGCATGTTGCAAGGTCTCCTGCCAGTCAGTCTCCTCCTCTCTGTTGCAGTAAGTGCTATAAAAGAACTCCCTG
GGGTGAAGAAGTATGAAGTGGTTTATCCTATAAGACTTCATCCACTGCATAAAAGAGAGGCCAAAGAGCCAGAGCAACAGATAGTCGTGC
AAGCACTGCAGTGTTCCCATTATTCGATTCTTTGGCAGTTGGTGAAAATTACTGATGGCTCTCCTTCCAAAGAGGATTTGTTGGTATTGA
GGAAAACGGTGAAATCCTTTTTGGCTGTTTGCCAGCAGTGCCTGTCTAATGTTAATACTCCAGTGAAAGAACAGGCTTTCATGTTACTCT
GTGATCTTCTGATGATTTTCAGCCACCAATTAATGACAGGTGGCAGAGAGGGCCTTCAGCCTTTGGTGTTCAATCCAGATACTGGACTCC
AATCTGAACTCCTCAGTTTTGTGATGGATCACGTTTTTATTGACCAAGACGAGGAGAACCAGAGCATGGAGGGTGATGAAGAAGATGAAG
CTAATAAAATTGAGGCCTTACATAAAAGAAGGAATCTACTTGCTGCTTTCAGCAAACTTATCATTTATGACATTGTTGACATGCATGCAG
CTGCAGACATCTTCAAACACTACATGAAGTTATTTAATGAACTTGTTCAAGAGCAAGGTCCCAACCTAGATAGGACATCTGCCCATGTCA
GTGGCATTAAAGAACTGGCACGTCGCTTTGCCCTTACATTTGGATTGGACCAGATTAAGACACGAGAAGCAGTTGCCACACTTCACAAGG
ATGGCATAGAGTTTGCATTTAAATACCAAAATCAGAAAGGACAAGAGTATCCACCTCCTAATCTGGCTTTTCTTGAAGTACTAAGTGAAT
TTTCTTCTAAACTTCTTCGACAGGACAAAAAGACAGTTCATTCATACCTAGAGAAATTCCTTACCGAGCAGATGATGGAAAGGAGGGAGG
ATGTATGGCTTCCACTCATCTCCTATAGAAATTCATTAGTCACTGGGGGTGAAGATGATAGAATGTCTGTGAACAGTGGAAGTAGCAGCA
GCAAAACCTCATCAGTAAGGAATAAGAAAGGACGACCTCCACTTCATAAAAAACGAGTAGAAGATGAGAGTCTGGATAACACATGGCTAA
ACAGGACTGACACCATGATTCAGACTCCTGGCCCCCTGCCAGCACCACAACTCACATCCACTGTACTGCGGGAGAACAGTCGGCCCATGG
GAGACCAGATTCAAGAACCTGAGTCTGAACATGGTTCTGAACCAGACTTTTTACACAATCCTCAGATGCAGATCTCTTGGTTAGGCCAGC
CGAAGTTAGAAGACTTAAATCGGAAGGACAGAACAGGAATGAACTACATGAAAGTGAGAACTGGAGTGAGGCATGCTGTTCGGGGTCTAA
TGGAGGAAGATGCTGAGCCCATCTTTGAAGATGTGATGATGTCATCCCGAAGCCAGTTAGAAGATATGAATGAAGAATTTGAGGACACCA
TGGTTATTGATCTGCCTCCATCAAGAAATCGGCGAGAGAGAGCTGAGCTAAGGCCAGACTTCTTTGACTCTGCAGCTATCATAGAAGATG
ATTCAGGATTTGGAATGCCTATGTTCTGAAGTCTGAAGAAAATTTACAAATCTGGAACTCTATTATTTAGAGCTAGAGGCCTATATACTG
TGATAGCTTGTATGGGGAAAAACACTTTTGATGTGATCTGATTTGTTTTTTAATCAAATGATTAAGGTCAATCCCTTTTTGCAGTGACAG
AAGAGGAGCATGTAAATTACCCAAGGGAATGTTGGTGAATGTCAACTCAGAAAGACTGACCTGAAAATCATTTGTGTCCTACTATTGGAC
TTATCCCAATACAGATGTGTGTGTTTTTCTGGAGGGAGGAAGAAATTTTAAATTTTTAAAACAGCTGTCAAGATAAACACTGTTATACAC
CTGTTTTATGAAAACTCAACATTGAGTAAAAAAAAACATATTTTTAACTTTATTTTCCTGTTGTACAATTTAAAAACCGTTTTAACATTT
TGCCTTTTTATGTTTTAAAAGCTAACCATTTTTATTAAACCTATGAGTAAGCAGCTCATCCTAATTGCGAAGAGTGTTTTGGAGTTCACT
GGATTTGGTTGACCTTTGTGGAACACAAATAATGAAGGAGCAGAACATTGACAAGCTAAGATGAAATTCTGACATAGTACATCTCTGCCA
AAAACCACACACCCTCTGTGGATATGGATATGAATTCCCAGATTTTATATACTCTTGAATAAAAGGTTTATTTTTATTTATAAGTGGGCA
TAAAATAAGAAATGTCCATGCAGCCATTTTTCCAACAGATGCTGTACACCGTTCATTTTATATAGACTAGGGAGATTCAAATACAGTGCA

>In-frame_ENST00000265769_ENST00000434713_TCGA-BH-A1EV-11A_ADAM28_chr8_24157590_+_STAG1_chr3_136117671_length(amino acids)=547AA_start in transcript=95_stop in transcript=1738
MESPSMLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQIVVQALQCSHYSILWQLVKITDGSPSKEDLLVLRK
TVKSFLAVCQQCLSNVNTPVKEQAFMLLCDLLMIFSHQLMTGGREGLQPLVFNPDTGLQSELLSFVMDHVFIDQDEENQSMEGDEEDEAN
KIEALHKRRNLLAAFSKLIIYDIVDMHAAADIFKHYMKLFNELVQEQGPNLDRTSAHVSGIKELARRFALTFGLDQIKTREAVATLHKDG
IEFAFKYQNQKGQEYPPPNLAFLEVLSEFSSKLLRQDKKTVHSYLEKFLTEQMMERREDVWLPLISYRNSLVTGGEDDRMSVNSGSSSSK
TSSVRNKKGRPPLHKKRVEDESLDNTWLNRTDTMIQTPGPLPAPQLTSTVLRENSRPMGDQIQEPESEHGSEPDFLHNPQMQISWLGQPK
LEDLNRKDRTGMNYMKVRTGVRHAVRGLMEEDAEPIFEDVMMSSRSQLEDMNEEFEDTMVIDLPPSRNRRERAELRPDFFDSAAIIEDDS

--------------------------------------------------------------
>In-frame_ENST00000437154_ENST00000383202_TCGA-BH-A1EV-11A_ADAM28_chr8_24157590_+_STAG1_chr3_136117671_length(transcript)=3789nt_BP=189nt
GCGAGAAGAGCAGACACCGTGCTCCTGGAATCACCCAGCATGTTGCAAGGTCTCCTGCCAGTCAGTCTCCTCCTCTCTGTTGCAGTAAGT
GCTATAAAAGAACTCCCTGGGGTGAAGAAGTATGAAGTGGTTTATCCTATAAGACTTCATCCACTGCATAAAAGAGAGGCCAAAGAGCCA
GAGCAACAGATAGTCGTGCAAGCACTGCAGTGTTCCCATTATTCGATTCTTTGGCAGTTGGTGAAAATTACTGATGGCTCTCCTTCCAAA
GAGGATTTGTTGGTATTGAGGAAAACGGTGAAATCCTTTTTGGCTGTTTGCCAGCAGTGCCTGTCTAATGTTAATACTCCAGTGAAAGAA
CAGGCTTTCATGTTACTCTGTGATCTTCTGATGATTTTCAGCCACCAATTAATGACAGGTGGCAGAGAGGGCCTTCAGCCTTTGGTGTTC
AATCCAGATACTGGACTCCAATCTGAACTCCTCAGTTTTGTGATGGATCACGTTTTTATTGACCAAGACGAGGAGAACCAGAGCATGGAG
GGTGATGAAGAAGATGAAGCTAATAAAATTGAGGCCTTACATAAAAGAAGGAATCTACTTGCTGCTTTCAGCAAACTTATCATTTATGAC
ATTGTTGACATGCATGCAGCTGCAGACATCTTCAAACACTACATGAAGTATTACAATGACTATGGTGATATTATTAAGGAAACACTGAGT
AAAACCAGGCAGATTGATAAAATTCAGTGTGCCAAGACTCTCATTCTCAGTTTGCAACAGTTATTTAATGAACTTGTTCAAGAGCAAGGT
CCCAACCTAGATAGGACATCTGCCCATGTCAGTGGCATTAAAGAACTGGCACGTCGCTTTGCCCTTACATTTGGATTGGACCAGATTAAG
ACACGAGAAGCAGTTGCCACACTTCACAAGGATGGCATAGAGTTTGCATTTAAATACCAAAATCAGAAAGGACAAGAGTATCCACCTCCT
AATCTGGCTTTTCTTGAAGTACTAAGTGAATTTTCTTCTAAACTTCTTCGACAGGACAAAAAGACAGTTCATTCATACCTAGAGAAATTC
CTTACCGAGCAGATGATGGAAAGGAGGGAGGATGTATGGCTTCCACTCATCTCCTATAGAAATTCATTAGTCACTGGGGGTGAAGATGAT
AGAATGTCTGTGAACAGTGGAAGTAGCAGCAGCAAAACCTCATCAGTAAGGAATAAGAAAGGACGACCTCCACTTCATAAAAAACGAGTA
GAAGATGAGAGTCTGGATAACACATGGCTAAACAGGACTGACACCATGATTCAGACTCCTGGCCCCCTGCCAGCACCACAACTCACATCC
ACTGTACTGCGGGAGAACAGTCGGCCCATGGGAGACCAGATTCAAGAACCTGAGTCTGAACATGGTTCTGAACCAGACTTTTTACACAAT
CCTCAGATGCAGATCTCTTGGTTAGGCCAGCCGAAGTTAGAAGACTTAAATCGGAAGGACAGAACAGGAATGAACTACATGAAAGTGAGA
ACTGGAGTGAGGCATGCTGTTCGGGGTCTAATGGAGGAAGATGCTGAGCCCATCTTTGAAGATGTGATGATGTCATCCCGAAGCCAGTTA
GAAGATATGAATGAAGAATTTGAGGACACCATGGTTATTGATCTGCCTCCATCAAGAAATCGGCGAGAGAGAGCTGAGCTAAGGCCAGAC
TTCTTTGACTCTGCAGCTATCATAGAAGATGATTCAGGATTTGGAATGCCTATGTTCTGAAGTCTGAAGAAAATTTACAAATCTGGAACT
CTATTATTTAGAGCTAGAGGCCTATATACTGTGATAGCTTGTATGGGGAAAAACACTTTTGATGTGATCTGATTTGTTTTTTAATCAAAT
GATTAAGGTCAATCCCTTTTTGCAGTGACAGAAGAGGAGCATGTAAATTACCCAAGGGAATGTTGGTGAATGTCAACTCAGAAAGACTGA
CCTGAAAATCATTTGTGTCCTACTATTGGACTTATCCCAATACAGATGTGTGTGTTTTTCTGGAGGGAGGAAGAAATTTTAAATTTTTAA
AACAGCTGTCAAGATAAACACTGTTATACACCTGTTTTATGAAAACTCAACATTGAGTAAAAAAAAACATATTTTTAACTTTATTTTCCT
GTTGTACAATTTAAAAACCGTTTTAACATTTTGCCTTTTTATGTTTTAAAAGCTAACCATTTTTATTAAACCTATGAGTAAGCAGCTCAT
CCTAATTGCGAAGAGTGTTTTGGAGTTCACTGGATTTGGTTGACCTTTGTGGAACACAAATAATGAAGGAGCAGAACATTGACAAGCTAA
GATGAAATTCTGACATAGTACATCTCTGCCAAAAACCACACACCCTCTGTGGATATGGATATGAATTCCCAGATTTTATATACTCTTGAA
TAAAAGGTTTATTTTTATTTATAAGTGGGCATAAAATAAGAAATGTCCATGCAGCCATTTTTCCAACAGATGCTGTACACCGTTCATTTT
ATATAGACTAGGGAGATTCAAATACAGTGCATTTTCTATTGGTATTTGTTCTGTGCATTTTTAGCAACTTCTACCAGCAAATAAAGTATT
CTCAGTAAAACGAAAATGATTCTCAAGTTATCAGTTTGCTGTTTTTACCACTTATTTCATGCCCTGCCAAATTCAAGTTACACAGACTTC
CATTTTCTTAAGATAATCAATCATGAAGAAATCCTTTATCAATCATTCAAAAGTAATTTTAAGTGTAACATAACTGTGTTTACTTCCCAT
GCACTTAATACCCTTATGCGCTAATTTTGTGAATTAAGTTTACTGATTATAGAAGTATGTGCTGCATAGAAGTCTGTGCTTAGAGGGTGA
AGTTCCTAAGCTTACCTTGAATTACAGCTACATTTCAGTGTTAAATGTGCATATTAAGAATAATTCTTTTGGGGAAAGAAATTATGAATC
TTCAGGACAGTCTACAATGGTTTAGAGTTACATTCTGCCTAGACTTTTATGACTTGCTGCTATTGTTTTAAAAACCCCACTTAGTCTCTC
TCTTCCTTTCTGATTTCTAAAGTAAGCCTCAGAATTTCCAAACCAATTCATCCACAGCTGTTTCTGGGCTGGTTTTTAAAGTAGCTGCAA
CAGAATCATGAGGCTTTCCCTTTTTATCAAATACGAAAAACATTTTTTAAAATTCTGCACACCCAGTGATCATCTTTTGTGCGGGAAAGC
AAGATGATGATGGATGATTTTATTCATCCTTTTAGTAAAGACACAAAACATTTTTCTCAACATTTGTACAGTTCTGAAAAAAACCTGGTC
ACCAAAAATATCTTCTCTGCTAATTCAGCAATTCTTGGGCTCCAGTTAGGGGAGCTGGGGCCTCACTTTCTCCCAGAATTGTGGGCTTCA
CTGGAAGTGAAGGTGCAGGAATGACTGGACTGTCCACCCCAGCCCTGCCTGCCTGTGGTTTTGGCCAGGGAGCAAGCCATGAGGTGCCCT
GGCACATGCACAAATTGATCCTTTGCGTGACAGTCTTGTATGGAAAACAGATGCTGACAGAATTGTAGACTACCATGCCACACAAAAAGG
CTAAATATCTACTCCAATGGGTTTCCAGTTCAGTTTGAAGTCAATCAAATTTTTGTATTTTCGGTGTCTCCTTGATTGGTTTTGCTAGTA
ATTCTGTAAATTGTACATTTGCAATATGAGGTTTTTTTTCCTTTTGTACAATTTGAAACTGATGCTTCACCTTTCCTTTAATAAACTATT

>In-frame_ENST00000437154_ENST00000383202_TCGA-BH-A1EV-11A_ADAM28_chr8_24157590_+_STAG1_chr3_136117671_length(amino acids)=581AA_start in transcript=24_stop in transcript=1769
MESPSMLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQIVVQALQCSHYSILWQLVKITDGSPSKEDLLVLRK
TVKSFLAVCQQCLSNVNTPVKEQAFMLLCDLLMIFSHQLMTGGREGLQPLVFNPDTGLQSELLSFVMDHVFIDQDEENQSMEGDEEDEAN
KIEALHKRRNLLAAFSKLIIYDIVDMHAAADIFKHYMKYYNDYGDIIKETLSKTRQIDKIQCAKTLILSLQQLFNELVQEQGPNLDRTSA
HVSGIKELARRFALTFGLDQIKTREAVATLHKDGIEFAFKYQNQKGQEYPPPNLAFLEVLSEFSSKLLRQDKKTVHSYLEKFLTEQMMER
REDVWLPLISYRNSLVTGGEDDRMSVNSGSSSSKTSSVRNKKGRPPLHKKRVEDESLDNTWLNRTDTMIQTPGPLPAPQLTSTVLRENSR
PMGDQIQEPESEHGSEPDFLHNPQMQISWLGQPKLEDLNRKDRTGMNYMKVRTGVRHAVRGLMEEDAEPIFEDVMMSSRSQLEDMNEEFE

--------------------------------------------------------------
>In-frame_ENST00000437154_ENST00000236698_TCGA-BH-A1EV-11A_ADAM28_chr8_24157590_+_STAG1_chr3_136117671_length(transcript)=3677nt_BP=189nt
GCGAGAAGAGCAGACACCGTGCTCCTGGAATCACCCAGCATGTTGCAAGGTCTCCTGCCAGTCAGTCTCCTCCTCTCTGTTGCAGTAAGT
GCTATAAAAGAACTCCCTGGGGTGAAGAAGTATGAAGTGGTTTATCCTATAAGACTTCATCCACTGCATAAAAGAGAGGCCAAAGAGCCA
GAGCAACAGATAGTCGTGCAAGCACTGCAGTGTTCCCATTATTCGATTCTTTGGCAGTTGGTGAAAATTACTGATGGCTCTCCTTCCAAA
GAGGATTTGTTGGTATTGAGGAAAACGGTGAAATCCTTTTTGGCTGTTTGCCAGCAGTGCCTGTCTAATGTTAATACTCCAGTGAAAGAA
CAGGCTTTCATGTTACTCTGTGATCTTCTGATGATTTTCAGCCACCAATTAATGACAGGTGGCAGAGAGGGCCTTCAGCCTTTGGTGTTC
AATCCAGATACTGGACTCCAATCTGAACTCCTCAGTTTTGTGATGGATCACGTTTTTATTGACCAAGACGAGGAGAACCAGAGCATGGAG
GGTGATGAAGAAGATGAAGCTAATAAAATTGAGGCCTTACATAAAAGAAGGAATCTACTTGCTGCTTTCAGCAAACTTATCATTTATGAC
ATTGTTGACATGCATGCAGCTGCAGACATCTTCAAACACTACATGAAGTATTACAATGACTATGGTGATATTATTAAGGAAACACTGAGT
AAAACCAGGCAGATTGATAAAATTCAGTGTGCCAAGACTCTCATTCTCAGTTTGCAACAGTTATTTAATGAACTTGTTCAAGAGCAAGGT
CCCAACCTAGATAGGACATCTGCCCATGTCAGTGGCATTAAAGAACTGGCACGTCGCTTTGCCCTTACATTTGGATTGGACCAGATTAAG
ACACGAGAAGCAGTTGCCACACTTCACAAGGATGGCATAGAGTTTGCATTTAAATACCAAAATCAGAAAGGACAAGAGTATCCACCTCCT
AATCTGGCTTTTCTTGAAGTACTAAGTGAATTTTCTTCTAAACTTCTTCGACAGGACAAAAAGACAGTTCATTCATACCTAGAGAAATTC
CTTACCGAGCAGATGATGGAAAGGAGGGAGGATGTATGGCTTCCACTCATCTCCTATAGAAATTCATTAGTCACTGGGGGTGAAGATGAT
AGAATGTCTGTGAACAGTGGAAGTAGCAGCAGCAAAACCTCATCAGTAAGGAATAAGAAAGGACGACCTCCACTTCATAAAAAACGAGTA
GAAGATGAGAGTCTGGATAACACATGGCTAAACAGGACTGACACCATGATTCAGACTCCTGGCCCCCTGCCAGCACCACAACTCACATCC
ACTGTACTGCGGGAGAACAGTCGGCCCATGGGAGACCAGATTCAAGAACCTGAGTCTGAACATGGTTCTGAACCAGACTTTTTACACAAT
CGGGGTCTAATGGAGGAAGATGCTGAGCCCATCTTTGAAGATGTGATGATGTCATCCCGAAGCCAGTTAGAAGATATGAATGAAGAATTT
GAGGACACCATGGTTATTGATCTGCCTCCATCAAGAAATCGGCGAGAGAGAGCTGAGCTAAGGCCAGACTTCTTTGACTCTGCAGCTATC
ATAGAAGATGATTCAGGATTTGGAATGCCTATGTTCTGAAGTCTGAAGAAAATTTACAAATCTGGAACTCTATTATTTAGAGCTAGAGGC
CTATATACTGTGATAGCTTGTATGGGGAAAAACACTTTTGATGTGATCTGATTTGTTTTTTAATCAAATGATTAAGGTCAATCCCTTTTT
GCAGTGACAGAAGAGGAGCATGTAAATTACCCAAGGGAATGTTGGTGAATGTCAACTCAGAAAGACTGACCTGAAAATCATTTGTGTCCT
ACTATTGGACTTATCCCAATACAGATGTGTGTGTTTTTCTGGAGGGAGGAAGAAATTTTAAATTTTTAAAACAGCTGTCAAGATAAACAC
TGTTATACACCTGTTTTATGAAAACTCAACATTGAGTAAAAAAAAACATATTTTTAACTTTATTTTCCTGTTGTACAATTTAAAAACCGT
TTTAACATTTTGCCTTTTTATGTTTTAAAAGCTAACCATTTTTATTAAACCTATGAGTAAGCAGCTCATCCTAATTGCGAAGAGTGTTTT
GGAGTTCACTGGATTTGGTTGACCTTTGTGGAACACAAATAATGAAGGAGCAGAACATTGACAAGCTAAGATGAAATTCTGACATAGTAC
ATCTCTGCCAAAAACCACACACCCTCTGTGGATATGGATATGAATTCCCAGATTTTATATACTCTTGAATAAAAGGTTTATTTTTATTTA
TAAGTGGGCATAAAATAAGAAATGTCCATGCAGCCATTTTTCCAACAGATGCTGTACACCGTTCATTTTATATAGACTAGGGAGATTCAA
ATACAGTGCATTTTCTATTGGTATTTGTTCTGTGCATTTTTAGCAACTTCTACCAGCAAATAAAGTATTCTCAGTAAAACGAAAATGATT
CTCAAGTTATCAGTTTGCTGTTTTTACCACTTATTTCATGCCCTGCCAAATTCAAGTTACACAGACTTCCATTTTCTTAAGATAATCAAT
CATGAAGAAATCCTTTATCAATCATTCAAAAGTAATTTTAAGTGTAACATAACTGTGTTTACTTCCCATGCACTTAATACCCTTATGCGC
TAATTTTGTGAATTAAGTTTACTGATTATAGAAGTATGTGCTGCATAGAAGTCTGTGCTTAGAGGGTGAAGTTCCTAAGCTTACCTTGAA
TTACAGCTACATTTCAGTGTTAAATGTGCATATTAAGAATAATTCTTTTGGGGAAAGAAATTATGAATCTTCAGGACAGTCTACAATGGT
TTAGAGTTACATTCTGCCTAGACTTTTATGACTTGCTGCTATTGTTTTAAAAACCCCACTTAGTCTCTCTCTTCCTTTCTGATTTCTAAA
GTAAGCCTCAGAATTTCCAAACCAATTCATCCACAGCTGTTTCTGGGCTGGTTTTTAAAGTAGCTGCAACAGAATCATGAGGCTTTCCCT
TTTTATCAAATACGAAAAACATTTTTTAAAATTCTGCACACCCAGTGATCATCTTTTGTGCGGGAAAGCAAGATGATGATGGATGATTTT
ATTCATCCTTTTAGTAAAGACACAAAACATTTTTCTCAACATTTGTACAGTTCTGAAAAAAACCTGGTCACCAAAAATATCTTCTCTGCT
AATTCAGCAATTCTTGGGCTCCAGTTAGGGGAGCTGGGGCCTCACTTTCTCCCAGAATTGTGGGCTTCACTGGAAGTGAAGGTGCAGGAA
TGACTGGACTGTCCACCCCAGCCCTGCCTGCCTGTGGTTTTGGCCAGGGAGCAAGCCATGAGGTGCCCTGGCACATGCACAAATTGATCC
TTTGCGTGACAGTCTTGTATGGAAAACAGATGCTGACAGAATTGTAGACTACCATGCCACACAAAAAGGCTAAATATCTACTCCAATGGG
TTTCCAGTTCAGTTTGAAGTCAATCAAATTTTTGTATTTTCGGTGTCTCCTTGATTGGTTTTGCTAGTAATTCTGTAAATTGTACATTTG

>In-frame_ENST00000437154_ENST00000236698_TCGA-BH-A1EV-11A_ADAM28_chr8_24157590_+_STAG1_chr3_136117671_length(amino acids)=544AA_start in transcript=24_stop in transcript=1658
MESPSMLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQIVVQALQCSHYSILWQLVKITDGSPSKEDLLVLRK
TVKSFLAVCQQCLSNVNTPVKEQAFMLLCDLLMIFSHQLMTGGREGLQPLVFNPDTGLQSELLSFVMDHVFIDQDEENQSMEGDEEDEAN
KIEALHKRRNLLAAFSKLIIYDIVDMHAAADIFKHYMKYYNDYGDIIKETLSKTRQIDKIQCAKTLILSLQQLFNELVQEQGPNLDRTSA
HVSGIKELARRFALTFGLDQIKTREAVATLHKDGIEFAFKYQNQKGQEYPPPNLAFLEVLSEFSSKLLRQDKKTVHSYLEKFLTEQMMER
REDVWLPLISYRNSLVTGGEDDRMSVNSGSSSSKTSSVRNKKGRPPLHKKRVEDESLDNTWLNRTDTMIQTPGPLPAPQLTSTVLRENSR
PMGDQIQEPESEHGSEPDFLHNRGLMEEDAEPIFEDVMMSSRSQLEDMNEEFEDTMVIDLPPSRNRRERAELRPDFFDSAAIIEDDSGFG

--------------------------------------------------------------
>In-frame_ENST00000437154_ENST00000434713_TCGA-BH-A1EV-11A_ADAM28_chr8_24157590_+_STAG1_chr3_136117671_length(transcript)=2532nt_BP=189nt
GCGAGAAGAGCAGACACCGTGCTCCTGGAATCACCCAGCATGTTGCAAGGTCTCCTGCCAGTCAGTCTCCTCCTCTCTGTTGCAGTAAGT
GCTATAAAAGAACTCCCTGGGGTGAAGAAGTATGAAGTGGTTTATCCTATAAGACTTCATCCACTGCATAAAAGAGAGGCCAAAGAGCCA
GAGCAACAGATAGTCGTGCAAGCACTGCAGTGTTCCCATTATTCGATTCTTTGGCAGTTGGTGAAAATTACTGATGGCTCTCCTTCCAAA
GAGGATTTGTTGGTATTGAGGAAAACGGTGAAATCCTTTTTGGCTGTTTGCCAGCAGTGCCTGTCTAATGTTAATACTCCAGTGAAAGAA
CAGGCTTTCATGTTACTCTGTGATCTTCTGATGATTTTCAGCCACCAATTAATGACAGGTGGCAGAGAGGGCCTTCAGCCTTTGGTGTTC
AATCCAGATACTGGACTCCAATCTGAACTCCTCAGTTTTGTGATGGATCACGTTTTTATTGACCAAGACGAGGAGAACCAGAGCATGGAG
GGTGATGAAGAAGATGAAGCTAATAAAATTGAGGCCTTACATAAAAGAAGGAATCTACTTGCTGCTTTCAGCAAACTTATCATTTATGAC
ATTGTTGACATGCATGCAGCTGCAGACATCTTCAAACACTACATGAAGTTATTTAATGAACTTGTTCAAGAGCAAGGTCCCAACCTAGAT
AGGACATCTGCCCATGTCAGTGGCATTAAAGAACTGGCACGTCGCTTTGCCCTTACATTTGGATTGGACCAGATTAAGACACGAGAAGCA
GTTGCCACACTTCACAAGGATGGCATAGAGTTTGCATTTAAATACCAAAATCAGAAAGGACAAGAGTATCCACCTCCTAATCTGGCTTTT
CTTGAAGTACTAAGTGAATTTTCTTCTAAACTTCTTCGACAGGACAAAAAGACAGTTCATTCATACCTAGAGAAATTCCTTACCGAGCAG
ATGATGGAAAGGAGGGAGGATGTATGGCTTCCACTCATCTCCTATAGAAATTCATTAGTCACTGGGGGTGAAGATGATAGAATGTCTGTG
AACAGTGGAAGTAGCAGCAGCAAAACCTCATCAGTAAGGAATAAGAAAGGACGACCTCCACTTCATAAAAAACGAGTAGAAGATGAGAGT
CTGGATAACACATGGCTAAACAGGACTGACACCATGATTCAGACTCCTGGCCCCCTGCCAGCACCACAACTCACATCCACTGTACTGCGG
GAGAACAGTCGGCCCATGGGAGACCAGATTCAAGAACCTGAGTCTGAACATGGTTCTGAACCAGACTTTTTACACAATCCTCAGATGCAG
ATCTCTTGGTTAGGCCAGCCGAAGTTAGAAGACTTAAATCGGAAGGACAGAACAGGAATGAACTACATGAAAGTGAGAACTGGAGTGAGG
CATGCTGTTCGGGGTCTAATGGAGGAAGATGCTGAGCCCATCTTTGAAGATGTGATGATGTCATCCCGAAGCCAGTTAGAAGATATGAAT
GAAGAATTTGAGGACACCATGGTTATTGATCTGCCTCCATCAAGAAATCGGCGAGAGAGAGCTGAGCTAAGGCCAGACTTCTTTGACTCT
GCAGCTATCATAGAAGATGATTCAGGATTTGGAATGCCTATGTTCTGAAGTCTGAAGAAAATTTACAAATCTGGAACTCTATTATTTAGA
GCTAGAGGCCTATATACTGTGATAGCTTGTATGGGGAAAAACACTTTTGATGTGATCTGATTTGTTTTTTAATCAAATGATTAAGGTCAA
TCCCTTTTTGCAGTGACAGAAGAGGAGCATGTAAATTACCCAAGGGAATGTTGGTGAATGTCAACTCAGAAAGACTGACCTGAAAATCAT
TTGTGTCCTACTATTGGACTTATCCCAATACAGATGTGTGTGTTTTTCTGGAGGGAGGAAGAAATTTTAAATTTTTAAAACAGCTGTCAA
GATAAACACTGTTATACACCTGTTTTATGAAAACTCAACATTGAGTAAAAAAAAACATATTTTTAACTTTATTTTCCTGTTGTACAATTT
AAAAACCGTTTTAACATTTTGCCTTTTTATGTTTTAAAAGCTAACCATTTTTATTAAACCTATGAGTAAGCAGCTCATCCTAATTGCGAA
GAGTGTTTTGGAGTTCACTGGATTTGGTTGACCTTTGTGGAACACAAATAATGAAGGAGCAGAACATTGACAAGCTAAGATGAAATTCTG
ACATAGTACATCTCTGCCAAAAACCACACACCCTCTGTGGATATGGATATGAATTCCCAGATTTTATATACTCTTGAATAAAAGGTTTAT
TTTTATTTATAAGTGGGCATAAAATAAGAAATGTCCATGCAGCCATTTTTCCAACAGATGCTGTACACCGTTCATTTTATATAGACTAGG
GAGATTCAAATACAGTGCATTTTCTATTGGTATTTGTTCTGTGCATTTTTAGCAACTTCTACCAGCAAATAAAGTATTCTCAGTAAAACG

>In-frame_ENST00000437154_ENST00000434713_TCGA-BH-A1EV-11A_ADAM28_chr8_24157590_+_STAG1_chr3_136117671_length(amino acids)=547AA_start in transcript=24_stop in transcript=1667
MESPSMLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQIVVQALQCSHYSILWQLVKITDGSPSKEDLLVLRK
TVKSFLAVCQQCLSNVNTPVKEQAFMLLCDLLMIFSHQLMTGGREGLQPLVFNPDTGLQSELLSFVMDHVFIDQDEENQSMEGDEEDEAN
KIEALHKRRNLLAAFSKLIIYDIVDMHAAADIFKHYMKLFNELVQEQGPNLDRTSAHVSGIKELARRFALTFGLDQIKTREAVATLHKDG
IEFAFKYQNQKGQEYPPPNLAFLEVLSEFSSKLLRQDKKTVHSYLEKFLTEQMMERREDVWLPLISYRNSLVTGGEDDRMSVNSGSSSSK
TSSVRNKKGRPPLHKKRVEDESLDNTWLNRTDTMIQTPGPLPAPQLTSTVLRENSRPMGDQIQEPESEHGSEPDFLHNPQMQISWLGQPK
LEDLNRKDRTGMNYMKVRTGVRHAVRGLMEEDAEPIFEDVMMSSRSQLEDMNEEFEDTMVIDLPPSRNRRERAELRPDFFDSAAIIEDDS

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Fusion Gene PPI Analysis for ADAM28-STAG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADAM28-STAG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneADAM28Q9UKQ2DB03088Pidolic acidSmall moleculeApproved|Investigational
HgeneADAM28Q9UKQ2DB03088Pidolic acidSmall moleculeApproved|Investigational
HgeneADAM28Q9UKQ2DB03088Pidolic acidSmall moleculeApproved|Investigational

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Related Diseases for ADAM28-STAG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADAM28C0024121Lung Neoplasms1CTD_human
HgeneADAM28C0033578Prostatic Neoplasms1CTD_human
HgeneADAM28C0242379Malignant neoplasm of lung1CTD_human
HgeneADAM28C0376358Malignant neoplasm of prostate1CTD_human
TgeneSTAG1C4539951MENTAL RETARDATION, AUTOSOMAL DOMINANT 472GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneSTAG1C0020796Profound Mental Retardation1CTD_human
TgeneSTAG1C0025363Mental Retardation, Psychosocial1CTD_human
TgeneSTAG1C0917816Mental deficiency1CTD_human
TgeneSTAG1C3714756Intellectual Disability1CTD_human