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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DAD1-RAB2B (FusionGDB2 ID:21263)

Fusion Gene Summary for DAD1-RAB2B

Fusion gene summary

Fusion gene information	Fusion gene name: DAD1-RAB2B
	Fusion gene ID: 21263
		Hgene	Tgene
	Gene symbol	DAD1	RAB2B
	Gene ID	1603	84932
	Gene name	defender against cell death 1	RAB2B, member RAS oncogene family
	Synonyms	OST2	-
	Cytomap	14q11.2	14q11.2
	Type of gene	protein-coding	protein-coding
	Description	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1DAD-1oligosaccharyl transferase subunit DAD1oligosaccharyltransferase 2 homologoligosaccharyltransferase subunit 2 (non-catalytic)	ras-related protein Rab-2BGTP-binding protein RAB2BRAS family, member RAB2B
	Modification date	20200327	20200327
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000250498, ENST00000489532, ENST00000538631, ENST00000543337,	ENST00000397762, ENST00000461909,
Fusion gene scores	* DoF score	9 X 6 X 4=216	3 X 2 X 2=12
	# samples	9	3
	** MAII score	log2(9/216*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: DAD1 [Title/Abstract] AND RAB2B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DAD1(23057853)-RAB2B(21936911), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across DAD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RAB2B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AC-A6IW-01A	DAD1	chr14	23057853	-	RAB2B	chr14	21936911	-
ChimerDB4	BRCA	TCGA-AC-A6IW-01A	DAD1	chr14	23057853	-	RAB2B	chr14	21936911	-

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Fusion Gene ORF analysis for DAD1-RAB2B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000250498	ENST00000397762	DAD1	chr14	23057853	-	RAB2B	chr14	21936911	-
5CDS-5UTR	ENST00000250498	ENST00000461909	DAD1	chr14	23057853	-	RAB2B	chr14	21936911	-
intron-3CDS	ENST00000489532	ENST00000397762	DAD1	chr14	23057853	-	RAB2B	chr14	21936911	-
intron-5UTR	ENST00000489532	ENST00000461909	DAD1	chr14	23057853	-	RAB2B	chr14	21936911	-
In-frame	ENST00000538631	ENST00000397762	DAD1	chr14	23057853	-	RAB2B	chr14	21936911	-
5CDS-5UTR	ENST00000538631	ENST00000461909	DAD1	chr14	23057853	-	RAB2B	chr14	21936911	-
intron-3CDS	ENST00000543337	ENST00000397762	DAD1	chr14	23057853	-	RAB2B	chr14	21936911	-
intron-5UTR	ENST00000543337	ENST00000461909	DAD1	chr14	23057853	-	RAB2B	chr14	21936911	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000250498	DAD1	chr14	23057853	-	ENST00000397762	RAB2B	chr14	21936911	-	2964	323	924	361	187
ENST00000538631	DAD1	chr14	23057853	-	ENST00000397762	RAB2B	chr14	21936911	-	2852	211	812	249	187

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000250498	ENST00000397762	DAD1	chr14	23057853	-	RAB2B	chr14	21936911	-	0.02636025	0.9736397
ENST00000538631	ENST00000397762	DAD1	chr14	23057853	-	RAB2B	chr14	21936911	-	0.016484464	0.98351556

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Fusion Genomic Features for DAD1-RAB2B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DAD1-RAB2B

Go to
FGviewer for the breakpoints of chr14:23057853-chr14:21936911
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DAD1

chr14:23057853

chr14:21936911

ENST00000250498

2_30

70.33333333333333

84.0

Topological domain

Cytoplasmic

Hgene

DAD1

chr14:23057853

chr14:21936911

ENST00000250498

52_52

70.33333333333333

84.0

Topological domain

Lumenal

Hgene

DAD1

chr14:23057853

chr14:21936911

ENST00000250498

31_51

70.33333333333333

84.0

Transmembrane

Helical

Hgene

DAD1

chr14:23057853

chr14:21936911

ENST00000250498

53_73

70.33333333333333

84.0

Transmembrane

Helical

Tgene

RAB2B

chr14:23057853

chr14:21936911

ENST00000397762

119_122

62.0

217.0

Nucleotide binding

GTP

Tgene

RAB2B

chr14:23057853

chr14:21936911

ENST00000397762

149_151

62.0

217.0

Nucleotide binding

GTP

Tgene

RAB2B

chr14:23057853

chr14:21936911

ENST00000397762

61_65

62.0

217.0

Nucleotide binding

GTP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DAD1

chr14:23057853

chr14:21936911

ENST00000250498

74_92

70.33333333333333

84.0

Topological domain

Cytoplasmic

Hgene

DAD1

chr14:23057853

chr14:21936911

ENST00000250498

93_113

70.33333333333333

84.0

Transmembrane

Helical

Tgene

RAB2B

chr14:23057853

chr14:21936911

ENST00000397762

35_43

62.0

217.0

Motif

Effector region

Tgene

RAB2B

chr14:23057853

chr14:21936911

ENST00000397762

13_21

62.0

217.0

Nucleotide binding

GTP

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Fusion Gene Sequence for DAD1-RAB2B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000250498_ENST00000397762_TCGA-AC-A6IW-01A_DAD1_chr14_23057853_-_RAB2B_chr14_21936911_length(transcript)=2964nt_BP=323nt
GGGGAGGGCGGAGTTAGGTCACGAGGGTGCGCATGCGCAAACAGCACATCCGGTGTGGTCGACGGGTCCTCCAAGAGTTTGGGGCGCGGA
CTGGAGTACCTTGCGTGCAGTTATGTCGGCGTCGGTAGTGTCTGTCATTTCGCGGTTCTTAGAAGAGTACTTGAGCTCCACTCCGCAGCG
TCTGAAGTTGCTGGACGCGTACCTGCTGTATATACTGCTGACCGGGGCGCTGCAGTTCGGTTACTGTCTCCTCGTGGGGACCTTCCCCTT
CAACTCTTTTCTCTCGGGCTTCATCTCTTGTGTGGGGAGTTTCATCCTAGCGGGCTGGGCAAGAATCCTTCCGTTCTATCACCCGTTCCT
ACTACAGGGGAGCAGCTGGAGCACTGCTGGTGTACGACATTACAAGGCGTGAAACCTTCAACCACCTGACCTCATGGTTAGAGGATGCCC
GGCAGCACTCTAGTTCCAACATGGTTATCATGCTCATTGGGAATAAGAGTGACCTAGAGTCCCGCAGGGATGTGAAGAGAGAAGAAGGAG
AGGCCTTTGCTAGGGAGCATGGACTTATATTCATGGAAACTTCAGCCAAAACAGCCTGCAATGTTGAAGAGGCCTTCATTAACACAGCCA
AAGAAATATATAGGAAGATCCAGCAGGGTTTATTTGATGTCCACAATGAGGCAAATGGCATCAAGATTGGGCCCCAACAGTCAATTTCAA
CATCAGTGGGACCCAGTGCCTCCCAGCGGAACTCTCGTGACATAGGGTCCAACTCTGGCTGCTGCTGAACATCTGGCTTGAACTTTTTTT
GTCCTTCCTGGAATAGCTTCAGATCAATAGGCTTAATGAAAGAGGTCTTTCTTGCTTTGGCTGAGAGCAGCCTCTTTTTAAAGTGTGATG
TTTTGCCTTTCCACCTAAAGACCAGGAGAGAATTTGGGCCCTTACTGACCTGTCCTCCTTCAGGGACATGAGCATTCCCTATAGATTAGG
GTTCTTCTTATCCTCCTATACAAATTTCTTAAATTGTTAGGATCAAAGTTGATTATCACAGTAGTTAAAAAATAATTTCATGGCGGGGCG
CCATGGCTCATGCCTGTAATCCTAGCACTTTGGGAGGCCAAGGTGGGCAGATCACCTGAGGTCAAGAGTTCGAGACCAGCCTGACCAACT
TGGAGAAATGCCATCTCAACTGAAAATACAAAATTAGCTGGGTGTGGTGGTGCATGCCTGTAATCCCAGGTACTCGGGAGGCCAAGGCAG
GAGAATCGCTTGAACCCAGGAGGTGAAGGTTACGCTAAGCCAAGATCACGCCATTGCACTGCAGCCTGGGCAACAAGAGCAAAACTCTGT
CTCAAATAAATAAATAATTTTTTTTTTCTTTTTTTTTTTTTTTTTTTGGGGGGATGGAGTCTCACTCTGTCTCCAGGCTGGAGTGCAGTG
GCATGATCTTGGCTCACTGCAACCTCCACTTTCCAGGTTCAAGCAGTTCTCCTGCCTCAACCTCCCGAGTAGCTGGGACTACAGGCATGT
GCCACCACACCTGGCTCATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGATGGTCTTGATCTCTTGACCTCGTGAT
CCGCCCACCTTGGCCTCCCAAAGTGCTGGATTACAGGTGTGAGCCACCGTGCCTGGCCTAAATAAATAATTTCGTAAGCATATACAATCC
ACTTCCCACTAAGAATTAGGGTCAAAGACATTCTATTTGAACACTTGCAATTACCTAGATCTAGTTGGCCTTTGGTTGATAGATCCTCTG
CCTCGGAATTTCATTGAGTTTTTTTCTTCCTTGCCTTTGGGTGTCTGCTTGCCACTTCCTAAGAATTCTTGTAGAAGGCAGTTTCCTCTA
CTTGCCCAAGAGCACTGAGTACTTCTCTACTATCCTATTATTAGCTTCTATCTCTTAGTGTAACTTCAAAACTTTTAAGAGCAGTGAAGT
TGGTCAGGGACATGTGGCCACTTATTATTACCTAAAGAAAACATTTGTTCCCTGTTCATTTTATTTTAGGGGCCAGATCTAACATTGTAG
TGTCTTTCACCAGATAGACTTCTACTGTTTCATCAAACTCCCTTCTTAACTAGACCTAGACTTTCTACTCCAATCAGGCTAATCTACTTA
CTGAATGTGACATATTTATTCCTAGTTCCATACCTTTGCACATGCCCTACTCTCCACTAATTATACTTAAAAGTCCAAAAATTTTTTCTT
TAGTAACAGACTTAGGTACTGCTAAGCAGTTATTAACACAATATTCCTTAGTTTTCATATGTTGGTTATTCATATGTCTATTTATATGTA
TATTTATTTTTATGTATGTTACTATGTAAATATGGTTTGCAGTTGTTTTTGTGTGGAATCTTGTCTTTCCGTATAAGTTGTAAGCTCCTT
GAGAGCAGGATCCATGTCATTCCTTTATTTTTATAAATTATTCCCCCTATCATTCCTTTACAGTGCCTAGTGCTACTCATTATGTGTTCA
TTGAATTTGACTGACATAGTTAAAAACTTAAGGTTTATTTTAGACTTTCAAGGAAACAAAAGACTTTAGAGTCCTCTCTCTGTAATTCTG
CCCCACTCATTTGTTTACCCTGGGTTTTATACAGTTCTCTTCCTTCTCCCCTCCCACCTTTCCCTGGCTTTTTGCCTCCATTCCATGAGG
CATACAGTAAGGCTGCCTGCTAGTAAGCAGTCACATAAGTGGGTACCTATCCAGCCATTCTCTTTTCAGAGCATATAATACTATCTTAGC
CAAACTTGCCTTTGCTTCACTCATCATGCAGCCTTCTGGGTTGGTTGCTATATATATCTTTTTTCCTTGATGTCCCGTTCTCTTCCACAG

>In-frame_ENST00000250498_ENST00000397762_TCGA-AC-A6IW-01A_DAD1_chr14_23057853_-_RAB2B_chr14_21936911_length(amino acids)=187AA_start in transcript=924_stop in transcript=361
MVFRWKGKTSHFKKRLLSAKARKTSFIKPIDLKLFQEGQKKFKPDVQQQPELDPMSREFRWEALGPTDVEIDCWGPILMPFASLWTSNKP
CWIFLYISLAVLMKASSTLQAVLAEVSMNISPCSLAKASPSSLFTSLRDSRSLLFPMSMITMLELECCRASSNHEVRWLKVSRLVMSYTS

--------------------------------------------------------------
>In-frame_ENST00000538631_ENST00000397762_TCGA-AC-A6IW-01A_DAD1_chr14_23057853_-_RAB2B_chr14_21936911_length(transcript)=2852nt_BP=211nt
ATGTCGGCGTCGGTAGTGTCTGTCATTTCGCGGTTCTTAGAAGAGTACTTGAGCTCCACTCCGCAGCGTCTGAAGTTGCTGGACGCGTAC
CTGCTGTATATACTGCTGACCGGGGCGCTGCAGTTCGGTTACTGTCTCCTCGTGGGGACCTTCCCCTTCAACTCTTTTCTCTCGGGCTTC
ATCTCTTGTGTGGGGAGTTTCATCCTAGCGGGCTGGGCAAGAATCCTTCCGTTCTATCACCCGTTCCTACTACAGGGGAGCAGCTGGAGC
ACTGCTGGTGTACGACATTACAAGGCGTGAAACCTTCAACCACCTGACCTCATGGTTAGAGGATGCCCGGCAGCACTCTAGTTCCAACAT
GGTTATCATGCTCATTGGGAATAAGAGTGACCTAGAGTCCCGCAGGGATGTGAAGAGAGAAGAAGGAGAGGCCTTTGCTAGGGAGCATGG
ACTTATATTCATGGAAACTTCAGCCAAAACAGCCTGCAATGTTGAAGAGGCCTTCATTAACACAGCCAAAGAAATATATAGGAAGATCCA
GCAGGGTTTATTTGATGTCCACAATGAGGCAAATGGCATCAAGATTGGGCCCCAACAGTCAATTTCAACATCAGTGGGACCCAGTGCCTC
CCAGCGGAACTCTCGTGACATAGGGTCCAACTCTGGCTGCTGCTGAACATCTGGCTTGAACTTTTTTTGTCCTTCCTGGAATAGCTTCAG
ATCAATAGGCTTAATGAAAGAGGTCTTTCTTGCTTTGGCTGAGAGCAGCCTCTTTTTAAAGTGTGATGTTTTGCCTTTCCACCTAAAGAC
CAGGAGAGAATTTGGGCCCTTACTGACCTGTCCTCCTTCAGGGACATGAGCATTCCCTATAGATTAGGGTTCTTCTTATCCTCCTATACA
AATTTCTTAAATTGTTAGGATCAAAGTTGATTATCACAGTAGTTAAAAAATAATTTCATGGCGGGGCGCCATGGCTCATGCCTGTAATCC
TAGCACTTTGGGAGGCCAAGGTGGGCAGATCACCTGAGGTCAAGAGTTCGAGACCAGCCTGACCAACTTGGAGAAATGCCATCTCAACTG
AAAATACAAAATTAGCTGGGTGTGGTGGTGCATGCCTGTAATCCCAGGTACTCGGGAGGCCAAGGCAGGAGAATCGCTTGAACCCAGGAG
GTGAAGGTTACGCTAAGCCAAGATCACGCCATTGCACTGCAGCCTGGGCAACAAGAGCAAAACTCTGTCTCAAATAAATAAATAATTTTT
TTTTTCTTTTTTTTTTTTTTTTTTTGGGGGGATGGAGTCTCACTCTGTCTCCAGGCTGGAGTGCAGTGGCATGATCTTGGCTCACTGCAA
CCTCCACTTTCCAGGTTCAAGCAGTTCTCCTGCCTCAACCTCCCGAGTAGCTGGGACTACAGGCATGTGCCACCACACCTGGCTCATTTT
TGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGATGGTCTTGATCTCTTGACCTCGTGATCCGCCCACCTTGGCCTCCCAAA
GTGCTGGATTACAGGTGTGAGCCACCGTGCCTGGCCTAAATAAATAATTTCGTAAGCATATACAATCCACTTCCCACTAAGAATTAGGGT
CAAAGACATTCTATTTGAACACTTGCAATTACCTAGATCTAGTTGGCCTTTGGTTGATAGATCCTCTGCCTCGGAATTTCATTGAGTTTT
TTTCTTCCTTGCCTTTGGGTGTCTGCTTGCCACTTCCTAAGAATTCTTGTAGAAGGCAGTTTCCTCTACTTGCCCAAGAGCACTGAGTAC
TTCTCTACTATCCTATTATTAGCTTCTATCTCTTAGTGTAACTTCAAAACTTTTAAGAGCAGTGAAGTTGGTCAGGGACATGTGGCCACT
TATTATTACCTAAAGAAAACATTTGTTCCCTGTTCATTTTATTTTAGGGGCCAGATCTAACATTGTAGTGTCTTTCACCAGATAGACTTC
TACTGTTTCATCAAACTCCCTTCTTAACTAGACCTAGACTTTCTACTCCAATCAGGCTAATCTACTTACTGAATGTGACATATTTATTCC
TAGTTCCATACCTTTGCACATGCCCTACTCTCCACTAATTATACTTAAAAGTCCAAAAATTTTTTCTTTAGTAACAGACTTAGGTACTGC
TAAGCAGTTATTAACACAATATTCCTTAGTTTTCATATGTTGGTTATTCATATGTCTATTTATATGTATATTTATTTTTATGTATGTTAC
TATGTAAATATGGTTTGCAGTTGTTTTTGTGTGGAATCTTGTCTTTCCGTATAAGTTGTAAGCTCCTTGAGAGCAGGATCCATGTCATTC
CTTTATTTTTATAAATTATTCCCCCTATCATTCCTTTACAGTGCCTAGTGCTACTCATTATGTGTTCATTGAATTTGACTGACATAGTTA
AAAACTTAAGGTTTATTTTAGACTTTCAAGGAAACAAAAGACTTTAGAGTCCTCTCTCTGTAATTCTGCCCCACTCATTTGTTTACCCTG
GGTTTTATACAGTTCTCTTCCTTCTCCCCTCCCACCTTTCCCTGGCTTTTTGCCTCCATTCCATGAGGCATACAGTAAGGCTGCCTGCTA
GTAAGCAGTCACATAAGTGGGTACCTATCCAGCCATTCTCTTTTCAGAGCATATAATACTATCTTAGCCAAACTTGCCTTTGCTTCACTC
ATCATGCAGCCTTCTGGGTTGGTTGCTATATATATCTTTTTTCCTTGATGTCCCGTTCTCTTCCACAGCCCTGAGGTCTTACGAATTTTT

>In-frame_ENST00000538631_ENST00000397762_TCGA-AC-A6IW-01A_DAD1_chr14_23057853_-_RAB2B_chr14_21936911_length(amino acids)=187AA_start in transcript=812_stop in transcript=249
MVFRWKGKTSHFKKRLLSAKARKTSFIKPIDLKLFQEGQKKFKPDVQQQPELDPMSREFRWEALGPTDVEIDCWGPILMPFASLWTSNKP
CWIFLYISLAVLMKASSTLQAVLAEVSMNISPCSLAKASPSSLFTSLRDSRSLLFPMSMITMLELECCRASSNHEVRWLKVSRLVMSYTS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DAD1-RAB2B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for DAD1-RAB2B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for DAD1-RAB2B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source