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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DCBLD1-MCM9 (FusionGDB2 ID:21558)

Fusion Gene Summary for DCBLD1-MCM9

check button Fusion gene summary
Fusion gene informationFusion gene name: DCBLD1-MCM9
Fusion gene ID: 21558
HgeneTgene
Gene symbol

DCBLD1

MCM9

Gene ID

285761

254394

Gene namediscoidin, CUB and LCCL domain containing 1minichromosome maintenance 9 homologous recombination repair factor
SynonymsdJ94G16.1C6orf61|MCMDC1|ODG4|dJ329L24.1|dJ329L24.3
Cytomap

6q22.1

6q22.31

Type of geneprotein-codingprotein-coding
Descriptiondiscoidin, CUB and LCCL domain-containing protein 1DNA helicase MCM9DNA replication licensing factor MCM9mini-chromosome maintenance deficient domain-containing protein 1minichromosome maintenance complex component 9
Modification date2020031320200313
UniProtAcc.

Q9NXL9

Ensembl transtripts involved in fusion geneENST00000368503, ENST00000296955, 
ENST00000338728, ENST00000534777, 
ENST00000316316, ENST00000505485, 
ENST00000316068, 
Fusion gene scores* DoF score8 X 6 X 5=2405 X 5 X 4=100
# samples 85
** MAII scorelog2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DCBLD1 [Title/Abstract] AND MCM9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDCBLD1(117825142)-MCM9(119177708), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMCM9

GO:0000724

double-strand break repair via homologous recombination

22771115

TgeneMCM9

GO:0006974

cellular response to DNA damage stimulus

22771115


check buttonFusion gene breakpoints across DCBLD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MCM9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4IY-01ADCBLD1chr6

117825142

+MCM9chr6

119177708

-


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Fusion Gene ORF analysis for DCBLD1-MCM9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000368503ENST00000316316DCBLD1chr6

117825142

+MCM9chr6

119177708

-
5CDS-5UTRENST00000368503ENST00000505485DCBLD1chr6

117825142

+MCM9chr6

119177708

-
5CDS-intronENST00000368503ENST00000316068DCBLD1chr6

117825142

+MCM9chr6

119177708

-
In-frameENST00000296955ENST00000316316DCBLD1chr6

117825142

+MCM9chr6

119177708

-
5CDS-5UTRENST00000296955ENST00000505485DCBLD1chr6

117825142

+MCM9chr6

119177708

-
5CDS-intronENST00000296955ENST00000316068DCBLD1chr6

117825142

+MCM9chr6

119177708

-
In-frameENST00000338728ENST00000316316DCBLD1chr6

117825142

+MCM9chr6

119177708

-
5CDS-5UTRENST00000338728ENST00000505485DCBLD1chr6

117825142

+MCM9chr6

119177708

-
5CDS-intronENST00000338728ENST00000316068DCBLD1chr6

117825142

+MCM9chr6

119177708

-
intron-3CDSENST00000534777ENST00000316316DCBLD1chr6

117825142

+MCM9chr6

119177708

-
intron-5UTRENST00000534777ENST00000505485DCBLD1chr6

117825142

+MCM9chr6

119177708

-
intron-intronENST00000534777ENST00000316068DCBLD1chr6

117825142

+MCM9chr6

119177708

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000368503DCBLD1chr6117825142+ENST00000316316MCM9chr6119177708-411445082731907
ENST00000296955DCBLD1chr6117825142+ENST00000316316MCM9chr6119177708-411445082731907
ENST00000338728DCBLD1chr6117825142+ENST00000316316MCM9chr6119177708-410944532726907

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000368503ENST00000316316DCBLD1chr6117825142+MCM9chr6119177708-0.000481330.99951863
ENST00000296955ENST00000316316DCBLD1chr6117825142+MCM9chr6119177708-0.000481330.99951863
ENST00000338728ENST00000316316DCBLD1chr6117825142+MCM9chr6119177708-0.0004683290.99953175

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Fusion Genomic Features for DCBLD1-MCM9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DCBLD1-MCM9


check button Go to

FGviewer for the breakpoints of chr6:117825142-chr6:119177708

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MCM9

Q9NXL9

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:26300262). In addition, recruits MLH1, a component of the MMR complex, to chromatin (PubMed:26300262). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). Probably by regulating HR, plays a key role during gametogenesis (By similarity). {ECO:0000250|UniProtKB:Q2KHI9, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:26215093, ECO:0000269|PubMed:26300262}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMCM9chr6:117825142chr6:119177708ENST0000031606807300_5050392.0DomainMCM
TgeneMCM9chr6:117825142chr6:119177708ENST0000031606807352_3590392.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDCBLD1chr6:117825142chr6:119177708ENST00000296955+215482_486108.33333333333333540.0Compositional biasNote=Poly-Lys
HgeneDCBLD1chr6:117825142chr6:119177708ENST00000338728+215482_486108.33333333333333716.0Compositional biasNote=Poly-Lys
HgeneDCBLD1chr6:117825142chr6:119177708ENST00000296955+215152_248108.33333333333333540.0DomainLCCL
HgeneDCBLD1chr6:117825142chr6:119177708ENST00000296955+215248_412108.33333333333333540.0DomainF5/8 type C
HgeneDCBLD1chr6:117825142chr6:119177708ENST00000296955+21541_150108.33333333333333540.0DomainCUB
HgeneDCBLD1chr6:117825142chr6:119177708ENST00000338728+215152_248108.33333333333333716.0DomainLCCL
HgeneDCBLD1chr6:117825142chr6:119177708ENST00000338728+215248_412108.33333333333333716.0DomainF5/8 type C
HgeneDCBLD1chr6:117825142chr6:119177708ENST00000338728+21541_150108.33333333333333716.0DomainCUB
HgeneDCBLD1chr6:117825142chr6:119177708ENST00000296955+21535_459108.33333333333333540.0Topological domainExtracellular
HgeneDCBLD1chr6:117825142chr6:119177708ENST00000296955+215481_715108.33333333333333540.0Topological domainCytoplasmic
HgeneDCBLD1chr6:117825142chr6:119177708ENST00000338728+21535_459108.33333333333333716.0Topological domainExtracellular
HgeneDCBLD1chr6:117825142chr6:119177708ENST00000338728+215481_715108.33333333333333716.0Topological domainCytoplasmic
HgeneDCBLD1chr6:117825142chr6:119177708ENST00000296955+215460_480108.33333333333333540.0TransmembraneHelical
HgeneDCBLD1chr6:117825142chr6:119177708ENST00000338728+215460_480108.33333333333333716.0TransmembraneHelical
TgeneMCM9chr6:117825142chr6:119177708ENST00000316316613300_505383.33333333333331144.0DomainMCM
TgeneMCM9chr6:117825142chr6:119177708ENST00000316316613352_359383.33333333333331144.0Nucleotide bindingATP


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Fusion Gene Sequence for DCBLD1-MCM9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000368503_ENST00000316316_TCGA-BR-A4IY-01A_DCBLD1_chr6_117825142_+_MCM9_chr6_119177708_length(transcript)=4114nt_BP=450nt
GGCAGCGACTGCGCCCCGTCCCGGCGCCGCGCTCGTCCGCAGAGGAGGCGGCCCGGCCCGGGCAGCTGCGGCTCGGGATCCGTCGAGGGG
AGGCCGAGCTTGCCAAGCTGGCGCCCAGCGGGGTCATGGTGCCCGGCGCCCGCGGCGGCGGCGCACTGGCGCGGGCTGCCGGGCGGGGCC
TCCTGGCTTTGCTGCTCGCGGTCTCCGCCCCGCTCCGGCTGCAGGCGGAGGAGCTGGGTGATGGCTGTGGACACCTAGTGACTTATCAGG
ATAGTGGCACAATGACATCTAAGAATTATCCCGGGACCTACCCCAATCACACTGTTTGCGAAAAGACAATTACAGTACCAAAGGGGAAAA
GACTGATTCTGAGGTTGGGAGATTTGGATATCGAATCCCAGACCTGTGCTTCTGACTATCTTCTCTTCACCAGCTCTTCAGATCAATATG
GTCTGACGGTAACTGCTGTAAAAGACTCAGGAGAATGGAATTTGGAGGCTGGGGCATTAGTTCTTGCAGATGCGGGCCTTTGCTGTATTG
ATGAGTTCAATAGCCTCAAAGAGCATGATAGGACCAGTATCCATGAAGCAATGGAGCAACAAACCATAAGTGTTGCTAAGGCTGGCCTCG
TGTGCAAGCTGAACACAAGGACCACCATCCTGGCAGCAACGAACCCCAAAGGCCAGTACGACCCCCAGGAGTCCGTGTCTGTGAACATTG
CCCTCGGCAGCCCACTCTTAAGTCGATTTGACCTGATCCTGGTTTTGCTTGATACCAAGAATGAAGACTGGGATCGTATCATTTCCTCCT
TTATCTTAGAAAATAAAGGTTACCCAAGCAAATCAGAGAAGCTCTGGAGCATGGAAAAGATGAAAACCTATTTCTGCCTCATAAGGAATC
TGCAGCCCACACTGTCTGATGTGGGCAATCAGGTTCTTCTCCGGTACTACCAGATGCAAAGGCAGAGTGATTGCCGGAACGCTGCCCGGA
CCACCATTCGGCTGTTGGAAAGCTTGATACGATTAGCAGAAGCTCATGCTCGCCTGATGTTTCGTGATACTGTAACTCTGGAAGACGCTA
TTACGGTGGTGTCAGTCATGGAGTCCTCAATGCAGGGAGGTGCACTGCTAGGAGGTGTGAATGCCCTCCACACTTCCTTTCCTGAAAACC
CTGGAGAGCAGTACCAGAGACAGTGTGAACTTATTCTGGAAAAGCTAGAGCTGCAGAGCCTCTTGAGTGAAGAGCTTAGAAGACTTGAAA
GGTTACAGAATCAGAGTGTGCACCAATCCCAACCACGGGTATTGGAGGTAGAGACTACTCCAGGATCCTTGAGAAATGGTCCAGGGGAAG
AATCAAACTTCAGAACTTCATCACAGCAGGAAATCAACTATAGCACACATATCTTCTCTCCTGGAGGCAGCCCCGAGGGAAGCCCAGTTC
TAGATCCCCCACCGCATCTGGAGCCTAATAGATCAACAAGTAGGAAACATTCAGCTCAGCACAAAAATAACAGAGATGACAGTTTAGATT
GGTTTGATTTCATGGCAACTCATCAGAGTGAACCTAAAAACACTGTTGTTGTGTCTCCTCATCCCAAAACATCTGGAGAAAATATGGCTT
CGAAGATCTCTAACAGCACATCTCAGGGTAAGGAGAAGAGTGAGCCAGGCCAAAGGAGCAAAGTGGACATTGGGTTGCTTCCATCACCAG
GAGAGACAGGTGTTCCATGGAGGGCAGACAATGTGGAAAGTAACAAGAAAAAAAGGCTAGCACTAGATTCTGAAGCAGCAGTCTCTGCTG
ATAAACCAGACTCAGTACTGACTCATCATGTCCCCAGGAACCTGCAGAAGCTGTGCAAAGAGAGGGCCCAGAAGTTGTGCAGAAATAGCA
CCAGGGTGCCTGCACAGTGCACAGTCCCTTCCCATCCTCAGTCCACTCCTGTACATAGCCCAGACAGAATGCTGGACTCACCCAAAAGAA
AGAGACCGAAATCCCTTGCGCAAGTGGAAGAGCCTGCAATTGAAAATGTTAAGCCTCCAGGTTCCCCTGTGGCCAAACTGGCAAAATTTA
CTTTCAAGCAGAAGTCAAAACTGATCCACTCCTTTGAAGATCACAGCCATGTGTCACCTGGTGCAACTAAAATAGCAGTTCATAGTCCTA
AAATTTCCCAGCGTAGAACAAGAAGAGACGCAGCCTTGCCGGTGAAGCGTCCAGGAAAGTTAACATCTACCCCAGGAAACCAGATCTCCA
GTCAGCCACAGGGTGAGACAAAGGAGGTGTCGCAGCAGCCACCAGAGAAACACGGACCAAGAGAGAAGGTGATGTGTGCCCCTGAGAAGA
GGATTATTCAGCCTGAATTAGAGCTTGGGAACGAGACTGGGTGTGCTCATCTTACTTGTGAGGGAGACAAAAAGGAAGAGGTTTCAGGCA
GTAATAAAAGCGGCAAGGTTCATGCCTGCACATTAGCCAGATTGGCAAACTTCTGCTTTACTCCCCCATCGGAATCCAAATCAAAATCCC
CTCCTCCTGAAAGGAAGAACCGAGGTGAGAGAGGCCCAAGCTCCCCTCCTACAACCACAGCTCCAATGCGTGTCAGTAAAAGGAAATCTT
TTCAGCTCCGTGGGTCCACCGAGAAACTGATTGTTTCCAAAGAATCCCTCTTCACTTTACCAGAACTAGGTGATGAAGCATTTGATTGTG
ACTGGGATGAAGAGATGAGAAAAAAGTCATAGTTGGGAAAAGCTTTCTGGTCAAATCTCACCTTCTTCAACTCCACAGAGGACCTTCAGG
ATATCAATATGGTATTTATAAATGTATAGAACAATTGGCCATATTGAGGATCACTCTGAATACTGGCTCCCCCTTAAGGCTTTCTAATTT
CAGGTTAATCTTCATGACTTAAAAAGTTGTATAATCAGTTGAGGTCAGTGTGATACCAGCAGCTGAGCTGAATTAATTATGTTGTGCTTA
ATTTTACAAATGGAGTACTTGTATTCCTGTTCCTGAAGCTGTTTCTGTTTTTTGTTTTGTTTTGTTTTTAAGGGGGAGAGGTTCTTCCCT
AGATTAATTTCTTCTTTCATTCACTCAGGAACAAATGTCAAGAAGGTAGCACTCATAAATCTAACAAGGCAGATGAACTCTTTTCTACTT
TTTTTTTTTTTTTTTGTATTTTCACCTGGAATGGGCTAAGTACAGTGAATATAATCACTTGGATGATTTGCCAAAATCAGACTATTTTTC
TAGTATTATTTTTGTATTGATTTGTGTGGATCAGGTTAAATGTGACTAATGCTTTTCTTTCTTTGAGAGGTATCCTTACAATTCCATGAT
GTTCTTAGAGATCTGGCCACTGGTCAAACAGTACCTTTCTGAAGTACTGACCTTCTGAGTTGTCCTTTCTTTCTTGAGCCAACATTTTGT
ACTTCAGATTCTTTTTTCTCTTGGGGGCCTACCTTCAACCAAGTAAAATACTGTGATTAGAAGAAGAGAGAGTATGAGCCAGGCACAGTG
ACTCACTCCTGTAGTCCTAGCTACTCGGGGAGGCTGAGGCAGGATGATTGCTTAAGCCCAGGAGTTCGGGGTTACAGTGAGCTGTGGTCA
CACCACTGTATTCCAGCCTGGGTGACAGAGTGAGATCCTGTCTCTAAAAATAAAATAAATGAAGAAGAGAGACTATGTGGTAGTCTCAAT
CAAACATCATGTCTCATCTACCCAGCTGGTTAATATGGAAATGTGATTCCTACTAAGTTGTGATTCACTTGTCTTTAAAACCAAGGAAAT
TATATACTGTTTTTGGTCAGAATAGATAACCTCAAGCTTTGTCTTTCTATGTGCTTTTAAAATCACTTATTCCTTTGGATTCTAATAAGG
GTTATTAGGATTCAGTAATTATGGACTTTCTCTTCTGAAGTGTGAATTTGTAAACTGATTGTTTAATTGTCAGAGGGACTTTTGGACATA
GAATACTCAAAACTATATGTATTTTGTTTAATTTTCACTTCATTCAATTCACGCATTGAAAACAAATTTAGAAAATCCAATTTTTCTTAA

>In-frame_ENST00000368503_ENST00000316316_TCGA-BR-A4IY-01A_DCBLD1_chr6_117825142_+_MCM9_chr6_119177708_length(amino acids)=907AA_start in transcript=8_stop in transcript=2731
MRPVPAPRSSAEEAARPGQLRLGIRRGEAELAKLAPSGVMVPGARGGGALARAAGRGLLALLLAVSAPLRLQAEELGDGCGHLVTYQDSG
TMTSKNYPGTYPNHTVCEKTITVPKGKRLILRLGDLDIESQTCASDYLLFTSSSDQYGLTVTAVKDSGEWNLEAGALVLADAGLCCIDEF
NSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFIL
ENKGYPSKSEKLWSMEKMKTYFCLIRNLQPTLSDVGNQVLLRYYQMQRQSDCRNAARTTIRLLESLIRLAEAHARLMFRDTVTLEDAITV
VSVMESSMQGGALLGGVNALHTSFPENPGEQYQRQCELILEKLELQSLLSEELRRLERLQNQSVHQSQPRVLEVETTPGSLRNGPGEESN
FRTSSQQEINYSTHIFSPGGSPEGSPVLDPPPHLEPNRSTSRKHSAQHKNNRDDSLDWFDFMATHQSEPKNTVVVSPHPKTSGENMASKI
SNSTSQGKEKSEPGQRSKVDIGLLPSPGETGVPWRADNVESNKKKRLALDSEAAVSADKPDSVLTHHVPRNLQKLCKERAQKLCRNSTRV
PAQCTVPSHPQSTPVHSPDRMLDSPKRKRPKSLAQVEEPAIENVKPPGSPVAKLAKFTFKQKSKLIHSFEDHSHVSPGATKIAVHSPKIS
QRRTRRDAALPVKRPGKLTSTPGNQISSQPQGETKEVSQQPPEKHGPREKVMCAPEKRIIQPELELGNETGCAHLTCEGDKKEEVSGSNK
SGKVHACTLARLANFCFTPPSESKSKSPPPERKNRGERGPSSPPTTTAPMRVSKRKSFQLRGSTEKLIVSKESLFTLPELGDEAFDCDWD

--------------------------------------------------------------
>In-frame_ENST00000296955_ENST00000316316_TCGA-BR-A4IY-01A_DCBLD1_chr6_117825142_+_MCM9_chr6_119177708_length(transcript)=4114nt_BP=450nt
GGCAGCGACTGCGCCCCGTCCCGGCGCCGCGCTCGTCCGCAGAGGAGGCGGCCCGGCCCGGGCAGCTGCGGCTCGGGATCCGTCGAGGGG
AGGCCGAGCTTGCCAAGCTGGCGCCCAGCGGGGTCATGGTGCCCGGCGCCCGCGGCGGCGGCGCACTGGCGCGGGCTGCCGGGCGGGGCC
TCCTGGCTTTGCTGCTCGCGGTCTCCGCCCCGCTCCGGCTGCAGGCGGAGGAGCTGGGTGATGGCTGTGGACACCTAGTGACTTATCAGG
ATAGTGGCACAATGACATCTAAGAATTATCCCGGGACCTACCCCAATCACACTGTTTGCGAAAAGACAATTACAGTACCAAAGGGGAAAA
GACTGATTCTGAGGTTGGGAGATTTGGATATCGAATCCCAGACCTGTGCTTCTGACTATCTTCTCTTCACCAGCTCTTCAGATCAATATG
GTCTGACGGTAACTGCTGTAAAAGACTCAGGAGAATGGAATTTGGAGGCTGGGGCATTAGTTCTTGCAGATGCGGGCCTTTGCTGTATTG
ATGAGTTCAATAGCCTCAAAGAGCATGATAGGACCAGTATCCATGAAGCAATGGAGCAACAAACCATAAGTGTTGCTAAGGCTGGCCTCG
TGTGCAAGCTGAACACAAGGACCACCATCCTGGCAGCAACGAACCCCAAAGGCCAGTACGACCCCCAGGAGTCCGTGTCTGTGAACATTG
CCCTCGGCAGCCCACTCTTAAGTCGATTTGACCTGATCCTGGTTTTGCTTGATACCAAGAATGAAGACTGGGATCGTATCATTTCCTCCT
TTATCTTAGAAAATAAAGGTTACCCAAGCAAATCAGAGAAGCTCTGGAGCATGGAAAAGATGAAAACCTATTTCTGCCTCATAAGGAATC
TGCAGCCCACACTGTCTGATGTGGGCAATCAGGTTCTTCTCCGGTACTACCAGATGCAAAGGCAGAGTGATTGCCGGAACGCTGCCCGGA
CCACCATTCGGCTGTTGGAAAGCTTGATACGATTAGCAGAAGCTCATGCTCGCCTGATGTTTCGTGATACTGTAACTCTGGAAGACGCTA
TTACGGTGGTGTCAGTCATGGAGTCCTCAATGCAGGGAGGTGCACTGCTAGGAGGTGTGAATGCCCTCCACACTTCCTTTCCTGAAAACC
CTGGAGAGCAGTACCAGAGACAGTGTGAACTTATTCTGGAAAAGCTAGAGCTGCAGAGCCTCTTGAGTGAAGAGCTTAGAAGACTTGAAA
GGTTACAGAATCAGAGTGTGCACCAATCCCAACCACGGGTATTGGAGGTAGAGACTACTCCAGGATCCTTGAGAAATGGTCCAGGGGAAG
AATCAAACTTCAGAACTTCATCACAGCAGGAAATCAACTATAGCACACATATCTTCTCTCCTGGAGGCAGCCCCGAGGGAAGCCCAGTTC
TAGATCCCCCACCGCATCTGGAGCCTAATAGATCAACAAGTAGGAAACATTCAGCTCAGCACAAAAATAACAGAGATGACAGTTTAGATT
GGTTTGATTTCATGGCAACTCATCAGAGTGAACCTAAAAACACTGTTGTTGTGTCTCCTCATCCCAAAACATCTGGAGAAAATATGGCTT
CGAAGATCTCTAACAGCACATCTCAGGGTAAGGAGAAGAGTGAGCCAGGCCAAAGGAGCAAAGTGGACATTGGGTTGCTTCCATCACCAG
GAGAGACAGGTGTTCCATGGAGGGCAGACAATGTGGAAAGTAACAAGAAAAAAAGGCTAGCACTAGATTCTGAAGCAGCAGTCTCTGCTG
ATAAACCAGACTCAGTACTGACTCATCATGTCCCCAGGAACCTGCAGAAGCTGTGCAAAGAGAGGGCCCAGAAGTTGTGCAGAAATAGCA
CCAGGGTGCCTGCACAGTGCACAGTCCCTTCCCATCCTCAGTCCACTCCTGTACATAGCCCAGACAGAATGCTGGACTCACCCAAAAGAA
AGAGACCGAAATCCCTTGCGCAAGTGGAAGAGCCTGCAATTGAAAATGTTAAGCCTCCAGGTTCCCCTGTGGCCAAACTGGCAAAATTTA
CTTTCAAGCAGAAGTCAAAACTGATCCACTCCTTTGAAGATCACAGCCATGTGTCACCTGGTGCAACTAAAATAGCAGTTCATAGTCCTA
AAATTTCCCAGCGTAGAACAAGAAGAGACGCAGCCTTGCCGGTGAAGCGTCCAGGAAAGTTAACATCTACCCCAGGAAACCAGATCTCCA
GTCAGCCACAGGGTGAGACAAAGGAGGTGTCGCAGCAGCCACCAGAGAAACACGGACCAAGAGAGAAGGTGATGTGTGCCCCTGAGAAGA
GGATTATTCAGCCTGAATTAGAGCTTGGGAACGAGACTGGGTGTGCTCATCTTACTTGTGAGGGAGACAAAAAGGAAGAGGTTTCAGGCA
GTAATAAAAGCGGCAAGGTTCATGCCTGCACATTAGCCAGATTGGCAAACTTCTGCTTTACTCCCCCATCGGAATCCAAATCAAAATCCC
CTCCTCCTGAAAGGAAGAACCGAGGTGAGAGAGGCCCAAGCTCCCCTCCTACAACCACAGCTCCAATGCGTGTCAGTAAAAGGAAATCTT
TTCAGCTCCGTGGGTCCACCGAGAAACTGATTGTTTCCAAAGAATCCCTCTTCACTTTACCAGAACTAGGTGATGAAGCATTTGATTGTG
ACTGGGATGAAGAGATGAGAAAAAAGTCATAGTTGGGAAAAGCTTTCTGGTCAAATCTCACCTTCTTCAACTCCACAGAGGACCTTCAGG
ATATCAATATGGTATTTATAAATGTATAGAACAATTGGCCATATTGAGGATCACTCTGAATACTGGCTCCCCCTTAAGGCTTTCTAATTT
CAGGTTAATCTTCATGACTTAAAAAGTTGTATAATCAGTTGAGGTCAGTGTGATACCAGCAGCTGAGCTGAATTAATTATGTTGTGCTTA
ATTTTACAAATGGAGTACTTGTATTCCTGTTCCTGAAGCTGTTTCTGTTTTTTGTTTTGTTTTGTTTTTAAGGGGGAGAGGTTCTTCCCT
AGATTAATTTCTTCTTTCATTCACTCAGGAACAAATGTCAAGAAGGTAGCACTCATAAATCTAACAAGGCAGATGAACTCTTTTCTACTT
TTTTTTTTTTTTTTTGTATTTTCACCTGGAATGGGCTAAGTACAGTGAATATAATCACTTGGATGATTTGCCAAAATCAGACTATTTTTC
TAGTATTATTTTTGTATTGATTTGTGTGGATCAGGTTAAATGTGACTAATGCTTTTCTTTCTTTGAGAGGTATCCTTACAATTCCATGAT
GTTCTTAGAGATCTGGCCACTGGTCAAACAGTACCTTTCTGAAGTACTGACCTTCTGAGTTGTCCTTTCTTTCTTGAGCCAACATTTTGT
ACTTCAGATTCTTTTTTCTCTTGGGGGCCTACCTTCAACCAAGTAAAATACTGTGATTAGAAGAAGAGAGAGTATGAGCCAGGCACAGTG
ACTCACTCCTGTAGTCCTAGCTACTCGGGGAGGCTGAGGCAGGATGATTGCTTAAGCCCAGGAGTTCGGGGTTACAGTGAGCTGTGGTCA
CACCACTGTATTCCAGCCTGGGTGACAGAGTGAGATCCTGTCTCTAAAAATAAAATAAATGAAGAAGAGAGACTATGTGGTAGTCTCAAT
CAAACATCATGTCTCATCTACCCAGCTGGTTAATATGGAAATGTGATTCCTACTAAGTTGTGATTCACTTGTCTTTAAAACCAAGGAAAT
TATATACTGTTTTTGGTCAGAATAGATAACCTCAAGCTTTGTCTTTCTATGTGCTTTTAAAATCACTTATTCCTTTGGATTCTAATAAGG
GTTATTAGGATTCAGTAATTATGGACTTTCTCTTCTGAAGTGTGAATTTGTAAACTGATTGTTTAATTGTCAGAGGGACTTTTGGACATA
GAATACTCAAAACTATATGTATTTTGTTTAATTTTCACTTCATTCAATTCACGCATTGAAAACAAATTTAGAAAATCCAATTTTTCTTAA

>In-frame_ENST00000296955_ENST00000316316_TCGA-BR-A4IY-01A_DCBLD1_chr6_117825142_+_MCM9_chr6_119177708_length(amino acids)=907AA_start in transcript=8_stop in transcript=2731
MRPVPAPRSSAEEAARPGQLRLGIRRGEAELAKLAPSGVMVPGARGGGALARAAGRGLLALLLAVSAPLRLQAEELGDGCGHLVTYQDSG
TMTSKNYPGTYPNHTVCEKTITVPKGKRLILRLGDLDIESQTCASDYLLFTSSSDQYGLTVTAVKDSGEWNLEAGALVLADAGLCCIDEF
NSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFIL
ENKGYPSKSEKLWSMEKMKTYFCLIRNLQPTLSDVGNQVLLRYYQMQRQSDCRNAARTTIRLLESLIRLAEAHARLMFRDTVTLEDAITV
VSVMESSMQGGALLGGVNALHTSFPENPGEQYQRQCELILEKLELQSLLSEELRRLERLQNQSVHQSQPRVLEVETTPGSLRNGPGEESN
FRTSSQQEINYSTHIFSPGGSPEGSPVLDPPPHLEPNRSTSRKHSAQHKNNRDDSLDWFDFMATHQSEPKNTVVVSPHPKTSGENMASKI
SNSTSQGKEKSEPGQRSKVDIGLLPSPGETGVPWRADNVESNKKKRLALDSEAAVSADKPDSVLTHHVPRNLQKLCKERAQKLCRNSTRV
PAQCTVPSHPQSTPVHSPDRMLDSPKRKRPKSLAQVEEPAIENVKPPGSPVAKLAKFTFKQKSKLIHSFEDHSHVSPGATKIAVHSPKIS
QRRTRRDAALPVKRPGKLTSTPGNQISSQPQGETKEVSQQPPEKHGPREKVMCAPEKRIIQPELELGNETGCAHLTCEGDKKEEVSGSNK
SGKVHACTLARLANFCFTPPSESKSKSPPPERKNRGERGPSSPPTTTAPMRVSKRKSFQLRGSTEKLIVSKESLFTLPELGDEAFDCDWD

--------------------------------------------------------------
>In-frame_ENST00000338728_ENST00000316316_TCGA-BR-A4IY-01A_DCBLD1_chr6_117825142_+_MCM9_chr6_119177708_length(transcript)=4109nt_BP=445nt
CGACTGCGCCCCGTCCCGGCGCCGCGCTCGTCCGCAGAGGAGGCGGCCCGGCCCGGGCAGCTGCGGCTCGGGATCCGTCGAGGGGAGGCC
GAGCTTGCCAAGCTGGCGCCCAGCGGGGTCATGGTGCCCGGCGCCCGCGGCGGCGGCGCACTGGCGCGGGCTGCCGGGCGGGGCCTCCTG
GCTTTGCTGCTCGCGGTCTCCGCCCCGCTCCGGCTGCAGGCGGAGGAGCTGGGTGATGGCTGTGGACACCTAGTGACTTATCAGGATAGT
GGCACAATGACATCTAAGAATTATCCCGGGACCTACCCCAATCACACTGTTTGCGAAAAGACAATTACAGTACCAAAGGGGAAAAGACTG
ATTCTGAGGTTGGGAGATTTGGATATCGAATCCCAGACCTGTGCTTCTGACTATCTTCTCTTCACCAGCTCTTCAGATCAATATGGTCTG
ACGGTAACTGCTGTAAAAGACTCAGGAGAATGGAATTTGGAGGCTGGGGCATTAGTTCTTGCAGATGCGGGCCTTTGCTGTATTGATGAG
TTCAATAGCCTCAAAGAGCATGATAGGACCAGTATCCATGAAGCAATGGAGCAACAAACCATAAGTGTTGCTAAGGCTGGCCTCGTGTGC
AAGCTGAACACAAGGACCACCATCCTGGCAGCAACGAACCCCAAAGGCCAGTACGACCCCCAGGAGTCCGTGTCTGTGAACATTGCCCTC
GGCAGCCCACTCTTAAGTCGATTTGACCTGATCCTGGTTTTGCTTGATACCAAGAATGAAGACTGGGATCGTATCATTTCCTCCTTTATC
TTAGAAAATAAAGGTTACCCAAGCAAATCAGAGAAGCTCTGGAGCATGGAAAAGATGAAAACCTATTTCTGCCTCATAAGGAATCTGCAG
CCCACACTGTCTGATGTGGGCAATCAGGTTCTTCTCCGGTACTACCAGATGCAAAGGCAGAGTGATTGCCGGAACGCTGCCCGGACCACC
ATTCGGCTGTTGGAAAGCTTGATACGATTAGCAGAAGCTCATGCTCGCCTGATGTTTCGTGATACTGTAACTCTGGAAGACGCTATTACG
GTGGTGTCAGTCATGGAGTCCTCAATGCAGGGAGGTGCACTGCTAGGAGGTGTGAATGCCCTCCACACTTCCTTTCCTGAAAACCCTGGA
GAGCAGTACCAGAGACAGTGTGAACTTATTCTGGAAAAGCTAGAGCTGCAGAGCCTCTTGAGTGAAGAGCTTAGAAGACTTGAAAGGTTA
CAGAATCAGAGTGTGCACCAATCCCAACCACGGGTATTGGAGGTAGAGACTACTCCAGGATCCTTGAGAAATGGTCCAGGGGAAGAATCA
AACTTCAGAACTTCATCACAGCAGGAAATCAACTATAGCACACATATCTTCTCTCCTGGAGGCAGCCCCGAGGGAAGCCCAGTTCTAGAT
CCCCCACCGCATCTGGAGCCTAATAGATCAACAAGTAGGAAACATTCAGCTCAGCACAAAAATAACAGAGATGACAGTTTAGATTGGTTT
GATTTCATGGCAACTCATCAGAGTGAACCTAAAAACACTGTTGTTGTGTCTCCTCATCCCAAAACATCTGGAGAAAATATGGCTTCGAAG
ATCTCTAACAGCACATCTCAGGGTAAGGAGAAGAGTGAGCCAGGCCAAAGGAGCAAAGTGGACATTGGGTTGCTTCCATCACCAGGAGAG
ACAGGTGTTCCATGGAGGGCAGACAATGTGGAAAGTAACAAGAAAAAAAGGCTAGCACTAGATTCTGAAGCAGCAGTCTCTGCTGATAAA
CCAGACTCAGTACTGACTCATCATGTCCCCAGGAACCTGCAGAAGCTGTGCAAAGAGAGGGCCCAGAAGTTGTGCAGAAATAGCACCAGG
GTGCCTGCACAGTGCACAGTCCCTTCCCATCCTCAGTCCACTCCTGTACATAGCCCAGACAGAATGCTGGACTCACCCAAAAGAAAGAGA
CCGAAATCCCTTGCGCAAGTGGAAGAGCCTGCAATTGAAAATGTTAAGCCTCCAGGTTCCCCTGTGGCCAAACTGGCAAAATTTACTTTC
AAGCAGAAGTCAAAACTGATCCACTCCTTTGAAGATCACAGCCATGTGTCACCTGGTGCAACTAAAATAGCAGTTCATAGTCCTAAAATT
TCCCAGCGTAGAACAAGAAGAGACGCAGCCTTGCCGGTGAAGCGTCCAGGAAAGTTAACATCTACCCCAGGAAACCAGATCTCCAGTCAG
CCACAGGGTGAGACAAAGGAGGTGTCGCAGCAGCCACCAGAGAAACACGGACCAAGAGAGAAGGTGATGTGTGCCCCTGAGAAGAGGATT
ATTCAGCCTGAATTAGAGCTTGGGAACGAGACTGGGTGTGCTCATCTTACTTGTGAGGGAGACAAAAAGGAAGAGGTTTCAGGCAGTAAT
AAAAGCGGCAAGGTTCATGCCTGCACATTAGCCAGATTGGCAAACTTCTGCTTTACTCCCCCATCGGAATCCAAATCAAAATCCCCTCCT
CCTGAAAGGAAGAACCGAGGTGAGAGAGGCCCAAGCTCCCCTCCTACAACCACAGCTCCAATGCGTGTCAGTAAAAGGAAATCTTTTCAG
CTCCGTGGGTCCACCGAGAAACTGATTGTTTCCAAAGAATCCCTCTTCACTTTACCAGAACTAGGTGATGAAGCATTTGATTGTGACTGG
GATGAAGAGATGAGAAAAAAGTCATAGTTGGGAAAAGCTTTCTGGTCAAATCTCACCTTCTTCAACTCCACAGAGGACCTTCAGGATATC
AATATGGTATTTATAAATGTATAGAACAATTGGCCATATTGAGGATCACTCTGAATACTGGCTCCCCCTTAAGGCTTTCTAATTTCAGGT
TAATCTTCATGACTTAAAAAGTTGTATAATCAGTTGAGGTCAGTGTGATACCAGCAGCTGAGCTGAATTAATTATGTTGTGCTTAATTTT
ACAAATGGAGTACTTGTATTCCTGTTCCTGAAGCTGTTTCTGTTTTTTGTTTTGTTTTGTTTTTAAGGGGGAGAGGTTCTTCCCTAGATT
AATTTCTTCTTTCATTCACTCAGGAACAAATGTCAAGAAGGTAGCACTCATAAATCTAACAAGGCAGATGAACTCTTTTCTACTTTTTTT
TTTTTTTTTTGTATTTTCACCTGGAATGGGCTAAGTACAGTGAATATAATCACTTGGATGATTTGCCAAAATCAGACTATTTTTCTAGTA
TTATTTTTGTATTGATTTGTGTGGATCAGGTTAAATGTGACTAATGCTTTTCTTTCTTTGAGAGGTATCCTTACAATTCCATGATGTTCT
TAGAGATCTGGCCACTGGTCAAACAGTACCTTTCTGAAGTACTGACCTTCTGAGTTGTCCTTTCTTTCTTGAGCCAACATTTTGTACTTC
AGATTCTTTTTTCTCTTGGGGGCCTACCTTCAACCAAGTAAAATACTGTGATTAGAAGAAGAGAGAGTATGAGCCAGGCACAGTGACTCA
CTCCTGTAGTCCTAGCTACTCGGGGAGGCTGAGGCAGGATGATTGCTTAAGCCCAGGAGTTCGGGGTTACAGTGAGCTGTGGTCACACCA
CTGTATTCCAGCCTGGGTGACAGAGTGAGATCCTGTCTCTAAAAATAAAATAAATGAAGAAGAGAGACTATGTGGTAGTCTCAATCAAAC
ATCATGTCTCATCTACCCAGCTGGTTAATATGGAAATGTGATTCCTACTAAGTTGTGATTCACTTGTCTTTAAAACCAAGGAAATTATAT
ACTGTTTTTGGTCAGAATAGATAACCTCAAGCTTTGTCTTTCTATGTGCTTTTAAAATCACTTATTCCTTTGGATTCTAATAAGGGTTAT
TAGGATTCAGTAATTATGGACTTTCTCTTCTGAAGTGTGAATTTGTAAACTGATTGTTTAATTGTCAGAGGGACTTTTGGACATAGAATA
CTCAAAACTATATGTATTTTGTTTAATTTTCACTTCATTCAATTCACGCATTGAAAACAAATTTAGAAAATCCAATTTTTCTTAAGCATT

>In-frame_ENST00000338728_ENST00000316316_TCGA-BR-A4IY-01A_DCBLD1_chr6_117825142_+_MCM9_chr6_119177708_length(amino acids)=907AA_start in transcript=3_stop in transcript=2726
MRPVPAPRSSAEEAARPGQLRLGIRRGEAELAKLAPSGVMVPGARGGGALARAAGRGLLALLLAVSAPLRLQAEELGDGCGHLVTYQDSG
TMTSKNYPGTYPNHTVCEKTITVPKGKRLILRLGDLDIESQTCASDYLLFTSSSDQYGLTVTAVKDSGEWNLEAGALVLADAGLCCIDEF
NSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFIL
ENKGYPSKSEKLWSMEKMKTYFCLIRNLQPTLSDVGNQVLLRYYQMQRQSDCRNAARTTIRLLESLIRLAEAHARLMFRDTVTLEDAITV
VSVMESSMQGGALLGGVNALHTSFPENPGEQYQRQCELILEKLELQSLLSEELRRLERLQNQSVHQSQPRVLEVETTPGSLRNGPGEESN
FRTSSQQEINYSTHIFSPGGSPEGSPVLDPPPHLEPNRSTSRKHSAQHKNNRDDSLDWFDFMATHQSEPKNTVVVSPHPKTSGENMASKI
SNSTSQGKEKSEPGQRSKVDIGLLPSPGETGVPWRADNVESNKKKRLALDSEAAVSADKPDSVLTHHVPRNLQKLCKERAQKLCRNSTRV
PAQCTVPSHPQSTPVHSPDRMLDSPKRKRPKSLAQVEEPAIENVKPPGSPVAKLAKFTFKQKSKLIHSFEDHSHVSPGATKIAVHSPKIS
QRRTRRDAALPVKRPGKLTSTPGNQISSQPQGETKEVSQQPPEKHGPREKVMCAPEKRIIQPELELGNETGCAHLTCEGDKKEEVSGSNK
SGKVHACTLARLANFCFTPPSESKSKSPPPERKNRGERGPSSPPTTTAPMRVSKRKSFQLRGSTEKLIVSKESLFTLPELGDEAFDCDWD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DCBLD1-MCM9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DCBLD1-MCM9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DCBLD1-MCM9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDCBLD1C0025202melanoma1CTD_human
TgeneMCM9C4015409OVARIAN DYSGENESIS 42CTD_human;GENOMICS_ENGLAND;ORPHANET