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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DCBLD1-NUS1 (FusionGDB2 ID:21559)

Fusion Gene Summary for DCBLD1-NUS1

check button Fusion gene summary
Fusion gene informationFusion gene name: DCBLD1-NUS1
Fusion gene ID: 21559
HgeneTgene
Gene symbol

DCBLD1

NUS1

Gene ID

285761

116150

Gene namediscoidin, CUB and LCCL domain containing 1NUS1 dehydrodolichyl diphosphate synthase subunit
SynonymsdJ94G16.1C6orf68|CDG1AA|MGC:7199|MRD55|NgBR|TANGO14
Cytomap

6q22.1

6q22.1

Type of geneprotein-codingprotein-coding
Descriptiondiscoidin, CUB and LCCL domain-containing protein 1dehydrodolichyl diphosphate synthase complex subunit NUS1Nogo-B receptorcis-prenyltransferase subunit NgBRdehydrodolichyl diphosphate syntase complex subunit NUS1di-trans,poly-cis-decaprenylcistransferasenuclear undecaprenyl pyrophosphate synthase 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000368503, ENST00000296955, 
ENST00000338728, ENST00000534777, 
ENST00000368494, 
Fusion gene scores* DoF score8 X 6 X 5=2403 X 1 X 3=9
# samples 83
** MAII scorelog2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DCBLD1 [Title/Abstract] AND NUS1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDCBLD1(117825142)-NUS1(118014205), # samples:1
NUS1(117997248)-DCBLD1(117890783), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNUS1

GO:0006489

dolichyl diphosphate biosynthetic process

28842490


check buttonFusion gene breakpoints across DCBLD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NUS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EE-A3AB-06ADCBLD1chr6

117825142

+NUS1chr6

118014205

+


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Fusion Gene ORF analysis for DCBLD1-NUS1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000368503ENST00000368494DCBLD1chr6

117825142

+NUS1chr6

118014205

+
In-frameENST00000296955ENST00000368494DCBLD1chr6

117825142

+NUS1chr6

118014205

+
In-frameENST00000338728ENST00000368494DCBLD1chr6

117825142

+NUS1chr6

118014205

+
intron-3CDSENST00000534777ENST00000368494DCBLD1chr6

117825142

+NUS1chr6

118014205

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000368503DCBLD1chr6117825142+ENST00000368494NUS1chr6118014205+45424508916302
ENST00000296955DCBLD1chr6117825142+ENST00000368494NUS1chr6118014205+45424508916302
ENST00000338728DCBLD1chr6117825142+ENST00000368494NUS1chr6118014205+45374453911302

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000368503ENST00000368494DCBLD1chr6117825142+NUS1chr6118014205+0.0003177620.9996823
ENST00000296955ENST00000368494DCBLD1chr6117825142+NUS1chr6118014205+0.0003177620.9996823
ENST00000338728ENST00000368494DCBLD1chr6117825142+NUS1chr6118014205+0.000314910.99968517

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Fusion Genomic Features for DCBLD1-NUS1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DCBLD1chr6117825142+NUS1chr6118014204+3.02E-050.99996984
DCBLD1chr6117825142+NUS1chr6118014204+3.02E-050.99996984

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DCBLD1-NUS1


check button Go to

FGviewer for the breakpoints of chr6:117825142-chr6:118014205

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNUS1chr6:117825142chr6:118014205ENST0000036849405290_292138.33333333333334294.0MotifRXG motif%3B crucial for prenyltransferase activity

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDCBLD1chr6:117825142chr6:118014205ENST00000296955+215482_486108.33333333333333540.0Compositional biasNote=Poly-Lys
HgeneDCBLD1chr6:117825142chr6:118014205ENST00000338728+215482_486108.33333333333333716.0Compositional biasNote=Poly-Lys
HgeneDCBLD1chr6:117825142chr6:118014205ENST00000296955+215152_248108.33333333333333540.0DomainLCCL
HgeneDCBLD1chr6:117825142chr6:118014205ENST00000296955+215248_412108.33333333333333540.0DomainF5/8 type C
HgeneDCBLD1chr6:117825142chr6:118014205ENST00000296955+21541_150108.33333333333333540.0DomainCUB
HgeneDCBLD1chr6:117825142chr6:118014205ENST00000338728+215152_248108.33333333333333716.0DomainLCCL
HgeneDCBLD1chr6:117825142chr6:118014205ENST00000338728+215248_412108.33333333333333716.0DomainF5/8 type C
HgeneDCBLD1chr6:117825142chr6:118014205ENST00000338728+21541_150108.33333333333333716.0DomainCUB
HgeneDCBLD1chr6:117825142chr6:118014205ENST00000296955+21535_459108.33333333333333540.0Topological domainExtracellular
HgeneDCBLD1chr6:117825142chr6:118014205ENST00000296955+215481_715108.33333333333333540.0Topological domainCytoplasmic
HgeneDCBLD1chr6:117825142chr6:118014205ENST00000338728+21535_459108.33333333333333716.0Topological domainExtracellular
HgeneDCBLD1chr6:117825142chr6:118014205ENST00000338728+215481_715108.33333333333333716.0Topological domainCytoplasmic
HgeneDCBLD1chr6:117825142chr6:118014205ENST00000296955+215460_480108.33333333333333540.0TransmembraneHelical
HgeneDCBLD1chr6:117825142chr6:118014205ENST00000338728+215460_480108.33333333333333716.0TransmembraneHelical
TgeneNUS1chr6:117825142chr6:118014205ENST0000036849405117_135138.33333333333334294.0TransmembraneHelical%3B Name%3D3
TgeneNUS1chr6:117825142chr6:118014205ENST00000368494051_23138.33333333333334294.0TransmembraneHelical%3B Name%3D1
TgeneNUS1chr6:117825142chr6:118014205ENST000003684940535_56138.33333333333334294.0TransmembraneHelical%3B Name%3D2


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Fusion Gene Sequence for DCBLD1-NUS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000368503_ENST00000368494_TCGA-EE-A3AB-06A_DCBLD1_chr6_117825142_+_NUS1_chr6_118014205_length(transcript)=4542nt_BP=450nt
GGCAGCGACTGCGCCCCGTCCCGGCGCCGCGCTCGTCCGCAGAGGAGGCGGCCCGGCCCGGGCAGCTGCGGCTCGGGATCCGTCGAGGGG
AGGCCGAGCTTGCCAAGCTGGCGCCCAGCGGGGTCATGGTGCCCGGCGCCCGCGGCGGCGGCGCACTGGCGCGGGCTGCCGGGCGGGGCC
TCCTGGCTTTGCTGCTCGCGGTCTCCGCCCCGCTCCGGCTGCAGGCGGAGGAGCTGGGTGATGGCTGTGGACACCTAGTGACTTATCAGG
ATAGTGGCACAATGACATCTAAGAATTATCCCGGGACCTACCCCAATCACACTGTTTGCGAAAAGACAATTACAGTACCAAAGGGGAAAA
GACTGATTCTGAGGTTGGGAGATTTGGATATCGAATCCCAGACCTGTGCTTCTGACTATCTTCTCTTCACCAGCTCTTCAGATCAATATG
GTATTTTCAAAAGAAATAATTCCAGATTGATGGATGAAATTTTAAAACAACAGCAAGAACTTCTGGGCCTAGATTGTTCAAAATACTCAC
CAGAATTTGCAAATAGTAATGACAAAGATGATCAAGTTTTAAATTGCCATTTGGCAGTGAAGGTGCTGTCTCCGGAAGATGGAAAAGCAG
ATATTGTAAGAGCTGCTCAGGACTTTTGCCAGTTAGTAGCCCAGAAGCAAAAGAGACCCACAGATTTGGATGTAGATACGTTAGCCAGTT
TACTTAGTTCAAATGGTTGTCCTGATCCTGATTTAGTATTGAAGTTCGGTCCTGTGGACAGCACATTAGGCTTTCTTCCCTGGCACATCA
GATTGACTGAGATTGTCTCTTTGCCTTCCCACCTAAACATCAGTTATGAGGACTTTTTCTCTGCCCTTCGTCAATATGCAGCCTGTGAAC
AGCGTCTGGGAAAGTAGTGGTCATTGGTTGCATAATTTGATTTGAGGCTTGTGGAGGAAAGGAACCAAGTGACTCTGATGTTTACAAAGC
ACCTATGAAACCCTGTACACACCTAGTTCATAATCCTCATAATTTATCAACAAACACAAAAAAGTGTCTTACTTGAGAGTGAGTGTGTGT
GTGTGCGTGTGCACGTGCACACATGTGCACGTTTGTATGTATGGAAATAAACTTATAAATGGGGACGTATTGGAGAAGGAAATACATAGA
CCTACAACTTTGAGCAAATAGCAGTGATGTTTTAGGAACTGAAATGTCACACTTAAAGTCTTCAGCCCAGCTACTTCCCTATTTTTGTGG
GGAGAAGAGGGCCTGATTAGAACTGTTCTGGTTGTGTTTGGCGGGAGGGGAATAATTTTTGTTCAGTCCTTCTTAGTGACCAAACTTTAA
TTTTTAAGAATAATATATTGACTTACTGAACTGAAGCATTCTGAGTTGAAAGGAGCTCCAGAGGAGTGGAGTTCTGTGTTGCTCACATGT
TAAAATCTTGCTCACCTTCAGAGCAGAGGGAATACCTATCTTCAGATATCCGTCCATTTTCATCTCTTAATTGTAGTCAAAAGTATGACT
TGAGAGTGTTGCTCTGGTATTCTGGGTTCTGAAGTCTGGTATTCTGGTATTCTGGGTTCAAAAGTATGACTTGAGAGTGTTGCTCTGGTA
TTCTGAGAGTTGCTCTGTATTCTGGGTTCTGAAGATTATTTGAAAAATAACTCCTACTACATTGAAATGCAGACTTAAAAATTTAAACAT
TGGATTAGGCAGTCAAAAAAACCAAGCAAGCATAAAAGGTCAATAAGTTGTAATCTTGATAGTAAAGGTGGAAAACTTATTATAAATGGA
AAGAAAGTTTTATTTCCTTTTTTGTTTGATGGGCAGTATGCCATATTATACCCAAAGTTCTTTTAAAAAATATTTCCATCAACCATTTTT
ATTTAAAATAAACATTTGAGGGAAGTTACCAAGGCAGCTTTTTTCCTCAAAAGTAACCTGTTCCTCTTTGGAATAGCACATTTTAGGGGC
ATGGTTAATACCTGAGATTTTTACTCAGTAAATCCTGATGGTTACTGTGTGTAAAATATCTTTAAGTAGGATTGAAGGCCTCTGTGGGGG
AATAAAATATTACCAAAGTCTATAAAAATAAATTTTACATGTTCTCTTTTATGACAGAGAGCAGCACTGGTTCTGTTATTTTTAAAATGA
ATAATTGATTTCTTGATAGGTGTTTAATATTTCTTCCCTCACTGCTGATTCTTAGATAGAAACCATTCTTTATATTTGATAGACTGCTTT
CAGAAAACCCTTATCAACAAGTGTACAATACTTATCTAAAACTATACATTTAGAATGGAGCAGTTTAATACTAGATCTCAGAAGTTTTGA
AAAATAGCAAAGAAGACTGGATTTGGAAAGCATGGTCTACAATTGGTTGTTAAATTCTGAAGCTATGAAGAATAAATGTTTCAACTTTGG
ATTATGAAACCCCATTTATGATTTTTTAAATACACTTGAAATAAAAATGATTAAACTAAATTTTGGTCCAGTGACATTACTTTGCACTGC
ATAATCCATTATACGTTGTACGACTTTTTTTTTTTGTTTTAATTTATTACTGAGAGTTTTGTGTGAAGCTACAGCATATCTAACCAGAGA
ATTTCTGATTCCTTATACTGTGATTATATTATATTGAGGCATTTGTAGTGCAGCTGAAGACTGAATTTATGCCTTTTGTAAACATGATAG
GTATAAATGTCTTATAAACATTCTGGAGTATGTATAGCTTTAATGAATGAAATTTAATGGACCTGATTAAAATGAAGGGATTTAATCGTT
GTTAAAGTTAAGTTAGTCAAATAAATTACCTACTGGAATATAGCCCAAGCCAGTAAAGGTTTAATATTTGCATTTTCGTGCTTTTATTTT
CTCCTTCCATTCATAAGTATATACTTGAAAGTACATCTGTAGCCTATGATTTGAGTCTCTTGAAGTTCTAGGAAGAGGCAAACTACAAAC
TACTAGGATTCTGATTTCAGATGTAGTCATTCCAGAACCTTCTCTTTATGAGTTCACCTGCTAGTACAATCTCCACAACTTGAATGGCAT
TGGTTGTTCTGTAATTCCTGCCAAAAGCATCACAAGTTGTACATCATCAAGGCTCCCTTTGCACTCCCAAGAAGAACTGGTAATTTTAAA
CAAAAGTATGTGTCTTTATTTGTATTGGAAAATACTGTCTTTAAATTGTTTCTTGTTGACACTCCCCACAATGGAAAAATTACCGAATTA
AACCTGTTTTATGGATGGCAGCTTGGAGCATAGCAAGAAGTTGGAGGATTTGAATTCCATTCCCAGTTCTCATTGTGTTTTGTTTCTTAA
AACTATAATAATCGGTTACTGTTATAAAGTTTAAAAGGTGGTTTTAATGTGAATAGCAAATTCTGGTATATCGTGACTAACGCTTAAGAA
TGCCTGTCTTTGAGAGGAAGGTGTTATAATATTAATGAACAGTGCCAAATACACTGTGCATATCTGCAATTTAATCTTTGAATGTATGTT
ACTGGATTAGCTCCCTCCTCCTGTGTGATGGTACCATGCATAGAGTCAATCAAATCCTTGTGATGTTTTGTATGGACTTTGACAATATGT
AAATAATGTGTAAAGCCAGTTTTTATGATTAAGGAATCAAATTTATTGAATTTTATTATTGAAAGTTGAAACTTAACATGTATGAACAAA
AACCAATAAAAGAATATACTCTTTTCATTGACTATAGTATTATGTGAATGCTACATTTGTTCTGAACACTTAGGGGCTGCAAAAATGTAA
TAAGAAATGCATATGACTAGATAGCAATAGTGTTTTTTTTAGATGGTATGCTCTTGATTGAAATATATTCTCACTTTTACCAGGTTAAAC
ATTTGGAATCTTATAATGTTACTTGCTTTTTGATAGATAATAGTGAAATAAATTCAGCTTTGCCATTGCTGGAGTTGTCAAAATTCCACA
GTAATTAAAATTTGAATTTTTACCGAATATGAAATTTCCAAATTAAAAACGTATATGTGTACTCTTTTAAAAAGGAATTTGATAGTTCTT
GTCAAATGAGAAAATTTAAAGGTAAGAGTTATGGTTTGTCTTATGCTGCATAGACTATTCACCTCCTAACTTGAAGGTCTAATCATAAGA
CAATTGTTTTTTTGTGCATAGTTTTCATCTAAAATTAAGTTTACCAAAGGCAAATAACTGCTTACTAGGAACTTCCTTTAGCAAAAATTA
CTATAAAGTTCAGGACAGTTTGAAATAAAACCCAGGAAACAAGATTAATGTGAGCAGTTCTCCAAGATCCTAACTGGTGGGACATAAACT
ATGATGCAATGGATAGGAAAAGGTAGTGCAAAAAGAATTTCTTAAGGTTTAAAAAATACACTTTTCATTATAGGAAAAAGAAGATTCAGA
GAAACAAAGGAATGTAACCTTATTGATTACATTTTTGGTGATCACCGAGAATTTTTTGTACTATATTTTAAAAAATGTATTCTACTGTAA

>In-frame_ENST00000368503_ENST00000368494_TCGA-EE-A3AB-06A_DCBLD1_chr6_117825142_+_NUS1_chr6_118014205_length(amino acids)=302AA_start in transcript=8_stop in transcript=916
MRPVPAPRSSAEEAARPGQLRLGIRRGEAELAKLAPSGVMVPGARGGGALARAAGRGLLALLLAVSAPLRLQAEELGDGCGHLVTYQDSG
TMTSKNYPGTYPNHTVCEKTITVPKGKRLILRLGDLDIESQTCASDYLLFTSSSDQYGIFKRNNSRLMDEILKQQQELLGLDCSKYSPEF
ANSNDKDDQVLNCHLAVKVLSPEDGKADIVRAAQDFCQLVAQKQKRPTDLDVDTLASLLSSNGCPDPDLVLKFGPVDSTLGFLPWHIRLT

--------------------------------------------------------------
>In-frame_ENST00000296955_ENST00000368494_TCGA-EE-A3AB-06A_DCBLD1_chr6_117825142_+_NUS1_chr6_118014205_length(transcript)=4542nt_BP=450nt
GGCAGCGACTGCGCCCCGTCCCGGCGCCGCGCTCGTCCGCAGAGGAGGCGGCCCGGCCCGGGCAGCTGCGGCTCGGGATCCGTCGAGGGG
AGGCCGAGCTTGCCAAGCTGGCGCCCAGCGGGGTCATGGTGCCCGGCGCCCGCGGCGGCGGCGCACTGGCGCGGGCTGCCGGGCGGGGCC
TCCTGGCTTTGCTGCTCGCGGTCTCCGCCCCGCTCCGGCTGCAGGCGGAGGAGCTGGGTGATGGCTGTGGACACCTAGTGACTTATCAGG
ATAGTGGCACAATGACATCTAAGAATTATCCCGGGACCTACCCCAATCACACTGTTTGCGAAAAGACAATTACAGTACCAAAGGGGAAAA
GACTGATTCTGAGGTTGGGAGATTTGGATATCGAATCCCAGACCTGTGCTTCTGACTATCTTCTCTTCACCAGCTCTTCAGATCAATATG
GTATTTTCAAAAGAAATAATTCCAGATTGATGGATGAAATTTTAAAACAACAGCAAGAACTTCTGGGCCTAGATTGTTCAAAATACTCAC
CAGAATTTGCAAATAGTAATGACAAAGATGATCAAGTTTTAAATTGCCATTTGGCAGTGAAGGTGCTGTCTCCGGAAGATGGAAAAGCAG
ATATTGTAAGAGCTGCTCAGGACTTTTGCCAGTTAGTAGCCCAGAAGCAAAAGAGACCCACAGATTTGGATGTAGATACGTTAGCCAGTT
TACTTAGTTCAAATGGTTGTCCTGATCCTGATTTAGTATTGAAGTTCGGTCCTGTGGACAGCACATTAGGCTTTCTTCCCTGGCACATCA
GATTGACTGAGATTGTCTCTTTGCCTTCCCACCTAAACATCAGTTATGAGGACTTTTTCTCTGCCCTTCGTCAATATGCAGCCTGTGAAC
AGCGTCTGGGAAAGTAGTGGTCATTGGTTGCATAATTTGATTTGAGGCTTGTGGAGGAAAGGAACCAAGTGACTCTGATGTTTACAAAGC
ACCTATGAAACCCTGTACACACCTAGTTCATAATCCTCATAATTTATCAACAAACACAAAAAAGTGTCTTACTTGAGAGTGAGTGTGTGT
GTGTGCGTGTGCACGTGCACACATGTGCACGTTTGTATGTATGGAAATAAACTTATAAATGGGGACGTATTGGAGAAGGAAATACATAGA
CCTACAACTTTGAGCAAATAGCAGTGATGTTTTAGGAACTGAAATGTCACACTTAAAGTCTTCAGCCCAGCTACTTCCCTATTTTTGTGG
GGAGAAGAGGGCCTGATTAGAACTGTTCTGGTTGTGTTTGGCGGGAGGGGAATAATTTTTGTTCAGTCCTTCTTAGTGACCAAACTTTAA
TTTTTAAGAATAATATATTGACTTACTGAACTGAAGCATTCTGAGTTGAAAGGAGCTCCAGAGGAGTGGAGTTCTGTGTTGCTCACATGT
TAAAATCTTGCTCACCTTCAGAGCAGAGGGAATACCTATCTTCAGATATCCGTCCATTTTCATCTCTTAATTGTAGTCAAAAGTATGACT
TGAGAGTGTTGCTCTGGTATTCTGGGTTCTGAAGTCTGGTATTCTGGTATTCTGGGTTCAAAAGTATGACTTGAGAGTGTTGCTCTGGTA
TTCTGAGAGTTGCTCTGTATTCTGGGTTCTGAAGATTATTTGAAAAATAACTCCTACTACATTGAAATGCAGACTTAAAAATTTAAACAT
TGGATTAGGCAGTCAAAAAAACCAAGCAAGCATAAAAGGTCAATAAGTTGTAATCTTGATAGTAAAGGTGGAAAACTTATTATAAATGGA
AAGAAAGTTTTATTTCCTTTTTTGTTTGATGGGCAGTATGCCATATTATACCCAAAGTTCTTTTAAAAAATATTTCCATCAACCATTTTT
ATTTAAAATAAACATTTGAGGGAAGTTACCAAGGCAGCTTTTTTCCTCAAAAGTAACCTGTTCCTCTTTGGAATAGCACATTTTAGGGGC
ATGGTTAATACCTGAGATTTTTACTCAGTAAATCCTGATGGTTACTGTGTGTAAAATATCTTTAAGTAGGATTGAAGGCCTCTGTGGGGG
AATAAAATATTACCAAAGTCTATAAAAATAAATTTTACATGTTCTCTTTTATGACAGAGAGCAGCACTGGTTCTGTTATTTTTAAAATGA
ATAATTGATTTCTTGATAGGTGTTTAATATTTCTTCCCTCACTGCTGATTCTTAGATAGAAACCATTCTTTATATTTGATAGACTGCTTT
CAGAAAACCCTTATCAACAAGTGTACAATACTTATCTAAAACTATACATTTAGAATGGAGCAGTTTAATACTAGATCTCAGAAGTTTTGA
AAAATAGCAAAGAAGACTGGATTTGGAAAGCATGGTCTACAATTGGTTGTTAAATTCTGAAGCTATGAAGAATAAATGTTTCAACTTTGG
ATTATGAAACCCCATTTATGATTTTTTAAATACACTTGAAATAAAAATGATTAAACTAAATTTTGGTCCAGTGACATTACTTTGCACTGC
ATAATCCATTATACGTTGTACGACTTTTTTTTTTTGTTTTAATTTATTACTGAGAGTTTTGTGTGAAGCTACAGCATATCTAACCAGAGA
ATTTCTGATTCCTTATACTGTGATTATATTATATTGAGGCATTTGTAGTGCAGCTGAAGACTGAATTTATGCCTTTTGTAAACATGATAG
GTATAAATGTCTTATAAACATTCTGGAGTATGTATAGCTTTAATGAATGAAATTTAATGGACCTGATTAAAATGAAGGGATTTAATCGTT
GTTAAAGTTAAGTTAGTCAAATAAATTACCTACTGGAATATAGCCCAAGCCAGTAAAGGTTTAATATTTGCATTTTCGTGCTTTTATTTT
CTCCTTCCATTCATAAGTATATACTTGAAAGTACATCTGTAGCCTATGATTTGAGTCTCTTGAAGTTCTAGGAAGAGGCAAACTACAAAC
TACTAGGATTCTGATTTCAGATGTAGTCATTCCAGAACCTTCTCTTTATGAGTTCACCTGCTAGTACAATCTCCACAACTTGAATGGCAT
TGGTTGTTCTGTAATTCCTGCCAAAAGCATCACAAGTTGTACATCATCAAGGCTCCCTTTGCACTCCCAAGAAGAACTGGTAATTTTAAA
CAAAAGTATGTGTCTTTATTTGTATTGGAAAATACTGTCTTTAAATTGTTTCTTGTTGACACTCCCCACAATGGAAAAATTACCGAATTA
AACCTGTTTTATGGATGGCAGCTTGGAGCATAGCAAGAAGTTGGAGGATTTGAATTCCATTCCCAGTTCTCATTGTGTTTTGTTTCTTAA
AACTATAATAATCGGTTACTGTTATAAAGTTTAAAAGGTGGTTTTAATGTGAATAGCAAATTCTGGTATATCGTGACTAACGCTTAAGAA
TGCCTGTCTTTGAGAGGAAGGTGTTATAATATTAATGAACAGTGCCAAATACACTGTGCATATCTGCAATTTAATCTTTGAATGTATGTT
ACTGGATTAGCTCCCTCCTCCTGTGTGATGGTACCATGCATAGAGTCAATCAAATCCTTGTGATGTTTTGTATGGACTTTGACAATATGT
AAATAATGTGTAAAGCCAGTTTTTATGATTAAGGAATCAAATTTATTGAATTTTATTATTGAAAGTTGAAACTTAACATGTATGAACAAA
AACCAATAAAAGAATATACTCTTTTCATTGACTATAGTATTATGTGAATGCTACATTTGTTCTGAACACTTAGGGGCTGCAAAAATGTAA
TAAGAAATGCATATGACTAGATAGCAATAGTGTTTTTTTTAGATGGTATGCTCTTGATTGAAATATATTCTCACTTTTACCAGGTTAAAC
ATTTGGAATCTTATAATGTTACTTGCTTTTTGATAGATAATAGTGAAATAAATTCAGCTTTGCCATTGCTGGAGTTGTCAAAATTCCACA
GTAATTAAAATTTGAATTTTTACCGAATATGAAATTTCCAAATTAAAAACGTATATGTGTACTCTTTTAAAAAGGAATTTGATAGTTCTT
GTCAAATGAGAAAATTTAAAGGTAAGAGTTATGGTTTGTCTTATGCTGCATAGACTATTCACCTCCTAACTTGAAGGTCTAATCATAAGA
CAATTGTTTTTTTGTGCATAGTTTTCATCTAAAATTAAGTTTACCAAAGGCAAATAACTGCTTACTAGGAACTTCCTTTAGCAAAAATTA
CTATAAAGTTCAGGACAGTTTGAAATAAAACCCAGGAAACAAGATTAATGTGAGCAGTTCTCCAAGATCCTAACTGGTGGGACATAAACT
ATGATGCAATGGATAGGAAAAGGTAGTGCAAAAAGAATTTCTTAAGGTTTAAAAAATACACTTTTCATTATAGGAAAAAGAAGATTCAGA
GAAACAAAGGAATGTAACCTTATTGATTACATTTTTGGTGATCACCGAGAATTTTTTGTACTATATTTTAAAAAATGTATTCTACTGTAA

>In-frame_ENST00000296955_ENST00000368494_TCGA-EE-A3AB-06A_DCBLD1_chr6_117825142_+_NUS1_chr6_118014205_length(amino acids)=302AA_start in transcript=8_stop in transcript=916
MRPVPAPRSSAEEAARPGQLRLGIRRGEAELAKLAPSGVMVPGARGGGALARAAGRGLLALLLAVSAPLRLQAEELGDGCGHLVTYQDSG
TMTSKNYPGTYPNHTVCEKTITVPKGKRLILRLGDLDIESQTCASDYLLFTSSSDQYGIFKRNNSRLMDEILKQQQELLGLDCSKYSPEF
ANSNDKDDQVLNCHLAVKVLSPEDGKADIVRAAQDFCQLVAQKQKRPTDLDVDTLASLLSSNGCPDPDLVLKFGPVDSTLGFLPWHIRLT

--------------------------------------------------------------
>In-frame_ENST00000338728_ENST00000368494_TCGA-EE-A3AB-06A_DCBLD1_chr6_117825142_+_NUS1_chr6_118014205_length(transcript)=4537nt_BP=445nt
CGACTGCGCCCCGTCCCGGCGCCGCGCTCGTCCGCAGAGGAGGCGGCCCGGCCCGGGCAGCTGCGGCTCGGGATCCGTCGAGGGGAGGCC
GAGCTTGCCAAGCTGGCGCCCAGCGGGGTCATGGTGCCCGGCGCCCGCGGCGGCGGCGCACTGGCGCGGGCTGCCGGGCGGGGCCTCCTG
GCTTTGCTGCTCGCGGTCTCCGCCCCGCTCCGGCTGCAGGCGGAGGAGCTGGGTGATGGCTGTGGACACCTAGTGACTTATCAGGATAGT
GGCACAATGACATCTAAGAATTATCCCGGGACCTACCCCAATCACACTGTTTGCGAAAAGACAATTACAGTACCAAAGGGGAAAAGACTG
ATTCTGAGGTTGGGAGATTTGGATATCGAATCCCAGACCTGTGCTTCTGACTATCTTCTCTTCACCAGCTCTTCAGATCAATATGGTATT
TTCAAAAGAAATAATTCCAGATTGATGGATGAAATTTTAAAACAACAGCAAGAACTTCTGGGCCTAGATTGTTCAAAATACTCACCAGAA
TTTGCAAATAGTAATGACAAAGATGATCAAGTTTTAAATTGCCATTTGGCAGTGAAGGTGCTGTCTCCGGAAGATGGAAAAGCAGATATT
GTAAGAGCTGCTCAGGACTTTTGCCAGTTAGTAGCCCAGAAGCAAAAGAGACCCACAGATTTGGATGTAGATACGTTAGCCAGTTTACTT
AGTTCAAATGGTTGTCCTGATCCTGATTTAGTATTGAAGTTCGGTCCTGTGGACAGCACATTAGGCTTTCTTCCCTGGCACATCAGATTG
ACTGAGATTGTCTCTTTGCCTTCCCACCTAAACATCAGTTATGAGGACTTTTTCTCTGCCCTTCGTCAATATGCAGCCTGTGAACAGCGT
CTGGGAAAGTAGTGGTCATTGGTTGCATAATTTGATTTGAGGCTTGTGGAGGAAAGGAACCAAGTGACTCTGATGTTTACAAAGCACCTA
TGAAACCCTGTACACACCTAGTTCATAATCCTCATAATTTATCAACAAACACAAAAAAGTGTCTTACTTGAGAGTGAGTGTGTGTGTGTG
CGTGTGCACGTGCACACATGTGCACGTTTGTATGTATGGAAATAAACTTATAAATGGGGACGTATTGGAGAAGGAAATACATAGACCTAC
AACTTTGAGCAAATAGCAGTGATGTTTTAGGAACTGAAATGTCACACTTAAAGTCTTCAGCCCAGCTACTTCCCTATTTTTGTGGGGAGA
AGAGGGCCTGATTAGAACTGTTCTGGTTGTGTTTGGCGGGAGGGGAATAATTTTTGTTCAGTCCTTCTTAGTGACCAAACTTTAATTTTT
AAGAATAATATATTGACTTACTGAACTGAAGCATTCTGAGTTGAAAGGAGCTCCAGAGGAGTGGAGTTCTGTGTTGCTCACATGTTAAAA
TCTTGCTCACCTTCAGAGCAGAGGGAATACCTATCTTCAGATATCCGTCCATTTTCATCTCTTAATTGTAGTCAAAAGTATGACTTGAGA
GTGTTGCTCTGGTATTCTGGGTTCTGAAGTCTGGTATTCTGGTATTCTGGGTTCAAAAGTATGACTTGAGAGTGTTGCTCTGGTATTCTG
AGAGTTGCTCTGTATTCTGGGTTCTGAAGATTATTTGAAAAATAACTCCTACTACATTGAAATGCAGACTTAAAAATTTAAACATTGGAT
TAGGCAGTCAAAAAAACCAAGCAAGCATAAAAGGTCAATAAGTTGTAATCTTGATAGTAAAGGTGGAAAACTTATTATAAATGGAAAGAA
AGTTTTATTTCCTTTTTTGTTTGATGGGCAGTATGCCATATTATACCCAAAGTTCTTTTAAAAAATATTTCCATCAACCATTTTTATTTA
AAATAAACATTTGAGGGAAGTTACCAAGGCAGCTTTTTTCCTCAAAAGTAACCTGTTCCTCTTTGGAATAGCACATTTTAGGGGCATGGT
TAATACCTGAGATTTTTACTCAGTAAATCCTGATGGTTACTGTGTGTAAAATATCTTTAAGTAGGATTGAAGGCCTCTGTGGGGGAATAA
AATATTACCAAAGTCTATAAAAATAAATTTTACATGTTCTCTTTTATGACAGAGAGCAGCACTGGTTCTGTTATTTTTAAAATGAATAAT
TGATTTCTTGATAGGTGTTTAATATTTCTTCCCTCACTGCTGATTCTTAGATAGAAACCATTCTTTATATTTGATAGACTGCTTTCAGAA
AACCCTTATCAACAAGTGTACAATACTTATCTAAAACTATACATTTAGAATGGAGCAGTTTAATACTAGATCTCAGAAGTTTTGAAAAAT
AGCAAAGAAGACTGGATTTGGAAAGCATGGTCTACAATTGGTTGTTAAATTCTGAAGCTATGAAGAATAAATGTTTCAACTTTGGATTAT
GAAACCCCATTTATGATTTTTTAAATACACTTGAAATAAAAATGATTAAACTAAATTTTGGTCCAGTGACATTACTTTGCACTGCATAAT
CCATTATACGTTGTACGACTTTTTTTTTTTGTTTTAATTTATTACTGAGAGTTTTGTGTGAAGCTACAGCATATCTAACCAGAGAATTTC
TGATTCCTTATACTGTGATTATATTATATTGAGGCATTTGTAGTGCAGCTGAAGACTGAATTTATGCCTTTTGTAAACATGATAGGTATA
AATGTCTTATAAACATTCTGGAGTATGTATAGCTTTAATGAATGAAATTTAATGGACCTGATTAAAATGAAGGGATTTAATCGTTGTTAA
AGTTAAGTTAGTCAAATAAATTACCTACTGGAATATAGCCCAAGCCAGTAAAGGTTTAATATTTGCATTTTCGTGCTTTTATTTTCTCCT
TCCATTCATAAGTATATACTTGAAAGTACATCTGTAGCCTATGATTTGAGTCTCTTGAAGTTCTAGGAAGAGGCAAACTACAAACTACTA
GGATTCTGATTTCAGATGTAGTCATTCCAGAACCTTCTCTTTATGAGTTCACCTGCTAGTACAATCTCCACAACTTGAATGGCATTGGTT
GTTCTGTAATTCCTGCCAAAAGCATCACAAGTTGTACATCATCAAGGCTCCCTTTGCACTCCCAAGAAGAACTGGTAATTTTAAACAAAA
GTATGTGTCTTTATTTGTATTGGAAAATACTGTCTTTAAATTGTTTCTTGTTGACACTCCCCACAATGGAAAAATTACCGAATTAAACCT
GTTTTATGGATGGCAGCTTGGAGCATAGCAAGAAGTTGGAGGATTTGAATTCCATTCCCAGTTCTCATTGTGTTTTGTTTCTTAAAACTA
TAATAATCGGTTACTGTTATAAAGTTTAAAAGGTGGTTTTAATGTGAATAGCAAATTCTGGTATATCGTGACTAACGCTTAAGAATGCCT
GTCTTTGAGAGGAAGGTGTTATAATATTAATGAACAGTGCCAAATACACTGTGCATATCTGCAATTTAATCTTTGAATGTATGTTACTGG
ATTAGCTCCCTCCTCCTGTGTGATGGTACCATGCATAGAGTCAATCAAATCCTTGTGATGTTTTGTATGGACTTTGACAATATGTAAATA
ATGTGTAAAGCCAGTTTTTATGATTAAGGAATCAAATTTATTGAATTTTATTATTGAAAGTTGAAACTTAACATGTATGAACAAAAACCA
ATAAAAGAATATACTCTTTTCATTGACTATAGTATTATGTGAATGCTACATTTGTTCTGAACACTTAGGGGCTGCAAAAATGTAATAAGA
AATGCATATGACTAGATAGCAATAGTGTTTTTTTTAGATGGTATGCTCTTGATTGAAATATATTCTCACTTTTACCAGGTTAAACATTTG
GAATCTTATAATGTTACTTGCTTTTTGATAGATAATAGTGAAATAAATTCAGCTTTGCCATTGCTGGAGTTGTCAAAATTCCACAGTAAT
TAAAATTTGAATTTTTACCGAATATGAAATTTCCAAATTAAAAACGTATATGTGTACTCTTTTAAAAAGGAATTTGATAGTTCTTGTCAA
ATGAGAAAATTTAAAGGTAAGAGTTATGGTTTGTCTTATGCTGCATAGACTATTCACCTCCTAACTTGAAGGTCTAATCATAAGACAATT
GTTTTTTTGTGCATAGTTTTCATCTAAAATTAAGTTTACCAAAGGCAAATAACTGCTTACTAGGAACTTCCTTTAGCAAAAATTACTATA
AAGTTCAGGACAGTTTGAAATAAAACCCAGGAAACAAGATTAATGTGAGCAGTTCTCCAAGATCCTAACTGGTGGGACATAAACTATGAT
GCAATGGATAGGAAAAGGTAGTGCAAAAAGAATTTCTTAAGGTTTAAAAAATACACTTTTCATTATAGGAAAAAGAAGATTCAGAGAAAC
AAAGGAATGTAACCTTATTGATTACATTTTTGGTGATCACCGAGAATTTTTTGTACTATATTTTAAAAAATGTATTCTACTGTAACAAGT

>In-frame_ENST00000338728_ENST00000368494_TCGA-EE-A3AB-06A_DCBLD1_chr6_117825142_+_NUS1_chr6_118014205_length(amino acids)=302AA_start in transcript=3_stop in transcript=911
MRPVPAPRSSAEEAARPGQLRLGIRRGEAELAKLAPSGVMVPGARGGGALARAAGRGLLALLLAVSAPLRLQAEELGDGCGHLVTYQDSG
TMTSKNYPGTYPNHTVCEKTITVPKGKRLILRLGDLDIESQTCASDYLLFTSSSDQYGIFKRNNSRLMDEILKQQQELLGLDCSKYSPEF
ANSNDKDDQVLNCHLAVKVLSPEDGKADIVRAAQDFCQLVAQKQKRPTDLDVDTLASLLSSNGCPDPDLVLKFGPVDSTLGFLPWHIRLT

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Fusion Gene PPI Analysis for DCBLD1-NUS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DCBLD1-NUS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DCBLD1-NUS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDCBLD1C0025202melanoma1CTD_human
TgeneNUS1C4310727CONGENITAL DISORDER OF GLYCOSYLATION, TYPE Iaa2CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneNUS1C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneNUS1C0025202melanoma1CTD_human
TgeneNUS1C0234133Extrapyramidal sign1GENOMICS_ENGLAND
TgeneNUS1C4693371MENTAL RETARDATION, AUTOSOMAL DOMINANT 55, WITH SEIZURES1GENOMICS_ENGLAND