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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DCN-VIM (FusionGDB2 ID:21632)

Fusion Gene Summary for DCN-VIM

check button Fusion gene summary
Fusion gene informationFusion gene name: DCN-VIM
Fusion gene ID: 21632
HgeneTgene
Gene symbol

DCN

VIM

Gene ID

1634

7431

Gene namedecorinvimentin
SynonymsCSCD|DSPG2|PG40|PGII|PGS2|SLRR1B-
Cytomap

12q21.33

10p13

Type of geneprotein-codingprotein-coding
Descriptiondecorinbone proteoglycan IIdermatan sulphate proteoglycans IIproteoglycan core proteinsmall leucine-rich protein 1Bvimentinepididymis secretory sperm binding protein
Modification date2020031320200327
UniProtAcc

P07585

VMAC

Ensembl transtripts involved in fusion geneENST00000052754, ENST00000425043, 
ENST00000393155, ENST00000228329, 
ENST00000303320, ENST00000552962, 
ENST00000441303, ENST00000420120, 
ENST00000547568, ENST00000456569, 
ENST00000546370, ENST00000546745, 
ENST00000550099, ENST00000551354, 
ENST00000548768, 		ENST00000544301, 
ENST00000224237, ENST00000485947, 
Fusion gene scores* DoF score7 X 7 X 2=9842 X 25 X 11=11550
# samples 741
** MAII scorelog2(7/98*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(41/11550*10)=-4.81612513168534
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DCN [Title/Abstract] AND VIM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDCN(91545431)-VIM(17278293), # samples:1
Anticipated loss of major functional domain due to fusion event.DCN-VIM seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
DCN-VIM seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
DCN-VIM seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
DCN-VIM seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDCN

GO:0010508

positive regulation of autophagy

23798385

HgeneDCN

GO:0010596

negative regulation of endothelial cell migration

23798385

HgeneDCN

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

23798385

HgeneDCN

GO:0016239

positive regulation of macroautophagy

23798385

HgeneDCN

GO:0016525

negative regulation of angiogenesis

23978385

HgeneDCN

GO:1900747

negative regulation of vascular endothelial growth factor signaling pathway

23798385


check buttonFusion gene breakpoints across DCN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across VIM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-BH-A0DL-11ADCNchr12

91545431

-VIMchr10

17278293

+


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Fusion Gene ORF analysis for DCN-VIM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000052754ENST00000544301DCNchr12

91545431

-VIMchr10

17278293

+
Frame-shiftENST00000052754ENST00000224237DCNchr12

91545431

-VIMchr10

17278293

+
5CDS-intronENST00000052754ENST00000485947DCNchr12

91545431

-VIMchr10

17278293

+
Frame-shiftENST00000425043ENST00000544301DCNchr12

91545431

-VIMchr10

17278293

+
Frame-shiftENST00000425043ENST00000224237DCNchr12

91545431

-VIMchr10

17278293

+
5CDS-intronENST00000425043ENST00000485947DCNchr12

91545431

-VIMchr10

17278293

+
In-frameENST00000393155ENST00000544301DCNchr12

91545431

-VIMchr10

17278293

+
In-frameENST00000393155ENST00000224237DCNchr12

91545431

-VIMchr10

17278293

+
5CDS-intronENST00000393155ENST00000485947DCNchr12

91545431

-VIMchr10

17278293

+
Frame-shiftENST00000228329ENST00000544301DCNchr12

91545431

-VIMchr10

17278293

+
Frame-shiftENST00000228329ENST00000224237DCNchr12

91545431

-VIMchr10

17278293

+
5CDS-intronENST00000228329ENST00000485947DCNchr12

91545431

-VIMchr10

17278293

+
intron-3CDSENST00000303320ENST00000544301DCNchr12

91545431

-VIMchr10

17278293

+
intron-3CDSENST00000303320ENST00000224237DCNchr12

91545431

-VIMchr10

17278293

+
intron-intronENST00000303320ENST00000485947DCNchr12

91545431

-VIMchr10

17278293

+
Frame-shiftENST00000552962ENST00000544301DCNchr12

91545431

-VIMchr10

17278293

+
Frame-shiftENST00000552962ENST00000224237DCNchr12

91545431

-VIMchr10

17278293

+
5CDS-intronENST00000552962ENST00000485947DCNchr12

91545431

-VIMchr10

17278293

+
intron-3CDSENST00000441303ENST00000544301DCNchr12

91545431

-VIMchr10

17278293

+
intron-3CDSENST00000441303ENST00000224237DCNchr12

91545431

-VIMchr10

17278293

+
intron-intronENST00000441303ENST00000485947DCNchr12

91545431

-VIMchr10

17278293

+
Frame-shiftENST00000420120ENST00000544301DCNchr12

91545431

-VIMchr10

17278293

+
Frame-shiftENST00000420120ENST00000224237DCNchr12

91545431

-VIMchr10

17278293

+
5CDS-intronENST00000420120ENST00000485947DCNchr12

91545431

-VIMchr10

17278293

+
Frame-shiftENST00000547568ENST00000544301DCNchr12

91545431

-VIMchr10

17278293

+
Frame-shiftENST00000547568ENST00000224237DCNchr12

91545431

-VIMchr10

17278293

+
5CDS-intronENST00000547568ENST00000485947DCNchr12

91545431

-VIMchr10

17278293

+
intron-3CDSENST00000456569ENST00000544301DCNchr12

91545431

-VIMchr10

17278293

+
intron-3CDSENST00000456569ENST00000224237DCNchr12

91545431

-VIMchr10

17278293

+
intron-intronENST00000456569ENST00000485947DCNchr12

91545431

-VIMchr10

17278293

+
intron-3CDSENST00000546370ENST00000544301DCNchr12

91545431

-VIMchr10

17278293

+
intron-3CDSENST00000546370ENST00000224237DCNchr12

91545431

-VIMchr10

17278293

+
intron-intronENST00000546370ENST00000485947DCNchr12

91545431

-VIMchr10

17278293

+
intron-3CDSENST00000546745ENST00000544301DCNchr12

91545431

-VIMchr10

17278293

+
intron-3CDSENST00000546745ENST00000224237DCNchr12

91545431

-VIMchr10

17278293

+
intron-intronENST00000546745ENST00000485947DCNchr12

91545431

-VIMchr10

17278293

+
intron-3CDSENST00000550099ENST00000544301DCNchr12

91545431

-VIMchr10

17278293

+
intron-3CDSENST00000550099ENST00000224237DCNchr12

91545431

-VIMchr10

17278293

+
intron-intronENST00000550099ENST00000485947DCNchr12

91545431

-VIMchr10

17278293

+
intron-3CDSENST00000551354ENST00000544301DCNchr12

91545431

-VIMchr10

17278293

+
intron-3CDSENST00000551354ENST00000224237DCNchr12

91545431

-VIMchr10

17278293

+
intron-intronENST00000551354ENST00000485947DCNchr12

91545431

-VIMchr10

17278293

+
intron-3CDSENST00000548768ENST00000544301DCNchr12

91545431

-VIMchr10

17278293

+
intron-3CDSENST00000548768ENST00000224237DCNchr12

91545431

-VIMchr10

17278293

+
intron-intronENST00000548768ENST00000485947DCNchr12

91545431

-VIMchr10

17278293

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000393155DCNchr1291545431-ENST00000544301VIMchr1017278293+158111392541195313
ENST00000393155DCNchr1291545431-ENST00000224237VIMchr1017278293+158911392541195313

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000393155ENST00000544301DCNchr1291545431-VIMchr1017278293+0.0015249080.99847513
ENST00000393155ENST00000224237DCNchr1291545431-VIMchr1017278293+0.0015300830.9984699

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Fusion Genomic Features for DCN-VIM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DCNchr1291545430-VIMchr1017278292+8.68E-050.9999132
DCNchr1291545430-VIMchr1017278292+8.68E-050.9999132

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DCN-VIM


check button Go to

FGviewer for the breakpoints of chr12:91545431-chr10:17278293

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DCN

P07585

VIM

VMAC

FUNCTION: May affect the rate of fibrils formation.169

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDCNchr12:91545431chr10:17278293ENST00000052754-7854_67295.0360.0Compositional biasNote=Cys-rich
HgeneDCNchr12:91545431chr10:17278293ENST00000228329-5654_67186.0251.0Compositional biasNote=Cys-rich
HgeneDCNchr12:91545431chr10:17278293ENST00000393155-7854_67295.0360.0Compositional biasNote=Cys-rich
HgeneDCNchr12:91545431chr10:17278293ENST00000420120-4554_67186.0251.0Compositional biasNote=Cys-rich
HgeneDCNchr12:91545431chr10:17278293ENST00000425043-3454_67148.0213.0Compositional biasNote=Cys-rich
HgeneDCNchr12:91545431chr10:17278293ENST00000547568-4554_67148.0213.0Compositional biasNote=Cys-rich
HgeneDCNchr12:91545431chr10:17278293ENST00000552962-8954_67295.0360.0Compositional biasNote=Cys-rich
HgeneDCNchr12:91545431chr10:17278293ENST00000052754-78118_141295.0360.0RepeatNote=LRR 3
HgeneDCNchr12:91545431chr10:17278293ENST00000052754-78142_162295.0360.0RepeatNote=LRR 4
HgeneDCNchr12:91545431chr10:17278293ENST00000052754-78163_186295.0360.0RepeatNote=LRR 5
HgeneDCNchr12:91545431chr10:17278293ENST00000052754-78187_212295.0360.0RepeatNote=LRR 6
HgeneDCNchr12:91545431chr10:17278293ENST00000052754-78213_233295.0360.0RepeatNote=LRR 7
HgeneDCNchr12:91545431chr10:17278293ENST00000052754-78234_257295.0360.0RepeatNote=LRR 8
HgeneDCNchr12:91545431chr10:17278293ENST00000052754-78258_281295.0360.0RepeatNote=LRR 9
HgeneDCNchr12:91545431chr10:17278293ENST00000052754-7873_93295.0360.0RepeatNote=LRR 1
HgeneDCNchr12:91545431chr10:17278293ENST00000052754-7894_117295.0360.0RepeatNote=LRR 2
HgeneDCNchr12:91545431chr10:17278293ENST00000228329-56118_141186.0251.0RepeatNote=LRR 3
HgeneDCNchr12:91545431chr10:17278293ENST00000228329-56142_162186.0251.0RepeatNote=LRR 4
HgeneDCNchr12:91545431chr10:17278293ENST00000228329-56163_186186.0251.0RepeatNote=LRR 5
HgeneDCNchr12:91545431chr10:17278293ENST00000228329-5673_93186.0251.0RepeatNote=LRR 1
HgeneDCNchr12:91545431chr10:17278293ENST00000228329-5694_117186.0251.0RepeatNote=LRR 2
HgeneDCNchr12:91545431chr10:17278293ENST00000393155-78118_141295.0360.0RepeatNote=LRR 3
HgeneDCNchr12:91545431chr10:17278293ENST00000393155-78142_162295.0360.0RepeatNote=LRR 4
HgeneDCNchr12:91545431chr10:17278293ENST00000393155-78163_186295.0360.0RepeatNote=LRR 5
HgeneDCNchr12:91545431chr10:17278293ENST00000393155-78187_212295.0360.0RepeatNote=LRR 6
HgeneDCNchr12:91545431chr10:17278293ENST00000393155-78213_233295.0360.0RepeatNote=LRR 7
HgeneDCNchr12:91545431chr10:17278293ENST00000393155-78234_257295.0360.0RepeatNote=LRR 8
HgeneDCNchr12:91545431chr10:17278293ENST00000393155-78258_281295.0360.0RepeatNote=LRR 9
HgeneDCNchr12:91545431chr10:17278293ENST00000393155-7873_93295.0360.0RepeatNote=LRR 1
HgeneDCNchr12:91545431chr10:17278293ENST00000393155-7894_117295.0360.0RepeatNote=LRR 2
HgeneDCNchr12:91545431chr10:17278293ENST00000420120-45118_141186.0251.0RepeatNote=LRR 3
HgeneDCNchr12:91545431chr10:17278293ENST00000420120-45142_162186.0251.0RepeatNote=LRR 4
HgeneDCNchr12:91545431chr10:17278293ENST00000420120-45163_186186.0251.0RepeatNote=LRR 5
HgeneDCNchr12:91545431chr10:17278293ENST00000420120-4573_93186.0251.0RepeatNote=LRR 1
HgeneDCNchr12:91545431chr10:17278293ENST00000420120-4594_117186.0251.0RepeatNote=LRR 2
HgeneDCNchr12:91545431chr10:17278293ENST00000425043-34118_141148.0213.0RepeatNote=LRR 3
HgeneDCNchr12:91545431chr10:17278293ENST00000425043-3473_93148.0213.0RepeatNote=LRR 1
HgeneDCNchr12:91545431chr10:17278293ENST00000425043-3494_117148.0213.0RepeatNote=LRR 2
HgeneDCNchr12:91545431chr10:17278293ENST00000547568-45118_141148.0213.0RepeatNote=LRR 3
HgeneDCNchr12:91545431chr10:17278293ENST00000547568-4573_93148.0213.0RepeatNote=LRR 1
HgeneDCNchr12:91545431chr10:17278293ENST00000547568-4594_117148.0213.0RepeatNote=LRR 2
HgeneDCNchr12:91545431chr10:17278293ENST00000552962-89118_141295.0360.0RepeatNote=LRR 3
HgeneDCNchr12:91545431chr10:17278293ENST00000552962-89142_162295.0360.0RepeatNote=LRR 4
HgeneDCNchr12:91545431chr10:17278293ENST00000552962-89163_186295.0360.0RepeatNote=LRR 5
HgeneDCNchr12:91545431chr10:17278293ENST00000552962-89187_212295.0360.0RepeatNote=LRR 6
HgeneDCNchr12:91545431chr10:17278293ENST00000552962-89213_233295.0360.0RepeatNote=LRR 7
HgeneDCNchr12:91545431chr10:17278293ENST00000552962-89234_257295.0360.0RepeatNote=LRR 8
HgeneDCNchr12:91545431chr10:17278293ENST00000552962-89258_281295.0360.0RepeatNote=LRR 9
HgeneDCNchr12:91545431chr10:17278293ENST00000552962-8973_93295.0360.0RepeatNote=LRR 1
HgeneDCNchr12:91545431chr10:17278293ENST00000552962-8994_117295.0360.0RepeatNote=LRR 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDCNchr12:91545431chr10:17278293ENST00000303320-1454_670173.0Compositional biasNote=Cys-rich
HgeneDCNchr12:91545431chr10:17278293ENST00000441303-1354_670.0173.0Compositional biasNote=Cys-rich
HgeneDCNchr12:91545431chr10:17278293ENST00000456569-1254_670.076.0Compositional biasNote=Cys-rich
HgeneDCNchr12:91545431chr10:17278293ENST00000052754-78282_304295.0360.0RepeatNote=LRR 10
HgeneDCNchr12:91545431chr10:17278293ENST00000052754-78305_334295.0360.0RepeatNote=LRR 11
HgeneDCNchr12:91545431chr10:17278293ENST00000052754-78335_359295.0360.0RepeatNote=LRR 12
HgeneDCNchr12:91545431chr10:17278293ENST00000228329-56187_212186.0251.0RepeatNote=LRR 6
HgeneDCNchr12:91545431chr10:17278293ENST00000228329-56213_233186.0251.0RepeatNote=LRR 7
HgeneDCNchr12:91545431chr10:17278293ENST00000228329-56234_257186.0251.0RepeatNote=LRR 8
HgeneDCNchr12:91545431chr10:17278293ENST00000228329-56258_281186.0251.0RepeatNote=LRR 9
HgeneDCNchr12:91545431chr10:17278293ENST00000228329-56282_304186.0251.0RepeatNote=LRR 10
HgeneDCNchr12:91545431chr10:17278293ENST00000228329-56305_334186.0251.0RepeatNote=LRR 11
HgeneDCNchr12:91545431chr10:17278293ENST00000228329-56335_359186.0251.0RepeatNote=LRR 12
HgeneDCNchr12:91545431chr10:17278293ENST00000303320-14118_1410173.0RepeatNote=LRR 3
HgeneDCNchr12:91545431chr10:17278293ENST00000303320-14142_1620173.0RepeatNote=LRR 4
HgeneDCNchr12:91545431chr10:17278293ENST00000303320-14163_1860173.0RepeatNote=LRR 5
HgeneDCNchr12:91545431chr10:17278293ENST00000303320-14187_2120173.0RepeatNote=LRR 6
HgeneDCNchr12:91545431chr10:17278293ENST00000303320-14213_2330173.0RepeatNote=LRR 7
HgeneDCNchr12:91545431chr10:17278293ENST00000303320-14234_2570173.0RepeatNote=LRR 8
HgeneDCNchr12:91545431chr10:17278293ENST00000303320-14258_2810173.0RepeatNote=LRR 9
HgeneDCNchr12:91545431chr10:17278293ENST00000303320-14282_3040173.0RepeatNote=LRR 10
HgeneDCNchr12:91545431chr10:17278293ENST00000303320-14305_3340173.0RepeatNote=LRR 11
HgeneDCNchr12:91545431chr10:17278293ENST00000303320-14335_3590173.0RepeatNote=LRR 12
HgeneDCNchr12:91545431chr10:17278293ENST00000303320-1473_930173.0RepeatNote=LRR 1
HgeneDCNchr12:91545431chr10:17278293ENST00000303320-1494_1170173.0RepeatNote=LRR 2
HgeneDCNchr12:91545431chr10:17278293ENST00000393155-78282_304295.0360.0RepeatNote=LRR 10
HgeneDCNchr12:91545431chr10:17278293ENST00000393155-78305_334295.0360.0RepeatNote=LRR 11
HgeneDCNchr12:91545431chr10:17278293ENST00000393155-78335_359295.0360.0RepeatNote=LRR 12
HgeneDCNchr12:91545431chr10:17278293ENST00000420120-45187_212186.0251.0RepeatNote=LRR 6
HgeneDCNchr12:91545431chr10:17278293ENST00000420120-45213_233186.0251.0RepeatNote=LRR 7
HgeneDCNchr12:91545431chr10:17278293ENST00000420120-45234_257186.0251.0RepeatNote=LRR 8
HgeneDCNchr12:91545431chr10:17278293ENST00000420120-45258_281186.0251.0RepeatNote=LRR 9
HgeneDCNchr12:91545431chr10:17278293ENST00000420120-45282_304186.0251.0RepeatNote=LRR 10
HgeneDCNchr12:91545431chr10:17278293ENST00000420120-45305_334186.0251.0RepeatNote=LRR 11
HgeneDCNchr12:91545431chr10:17278293ENST00000420120-45335_359186.0251.0RepeatNote=LRR 12
HgeneDCNchr12:91545431chr10:17278293ENST00000425043-34142_162148.0213.0RepeatNote=LRR 4
HgeneDCNchr12:91545431chr10:17278293ENST00000425043-34163_186148.0213.0RepeatNote=LRR 5
HgeneDCNchr12:91545431chr10:17278293ENST00000425043-34187_212148.0213.0RepeatNote=LRR 6
HgeneDCNchr12:91545431chr10:17278293ENST00000425043-34213_233148.0213.0RepeatNote=LRR 7
HgeneDCNchr12:91545431chr10:17278293ENST00000425043-34234_257148.0213.0RepeatNote=LRR 8
HgeneDCNchr12:91545431chr10:17278293ENST00000425043-34258_281148.0213.0RepeatNote=LRR 9
HgeneDCNchr12:91545431chr10:17278293ENST00000425043-34282_304148.0213.0RepeatNote=LRR 10
HgeneDCNchr12:91545431chr10:17278293ENST00000425043-34305_334148.0213.0RepeatNote=LRR 11
HgeneDCNchr12:91545431chr10:17278293ENST00000425043-34335_359148.0213.0RepeatNote=LRR 12
HgeneDCNchr12:91545431chr10:17278293ENST00000441303-13118_1410.0173.0RepeatNote=LRR 3
HgeneDCNchr12:91545431chr10:17278293ENST00000441303-13142_1620.0173.0RepeatNote=LRR 4
HgeneDCNchr12:91545431chr10:17278293ENST00000441303-13163_1860.0173.0RepeatNote=LRR 5
HgeneDCNchr12:91545431chr10:17278293ENST00000441303-13187_2120.0173.0RepeatNote=LRR 6
HgeneDCNchr12:91545431chr10:17278293ENST00000441303-13213_2330.0173.0RepeatNote=LRR 7
HgeneDCNchr12:91545431chr10:17278293ENST00000441303-13234_2570.0173.0RepeatNote=LRR 8
HgeneDCNchr12:91545431chr10:17278293ENST00000441303-13258_2810.0173.0RepeatNote=LRR 9
HgeneDCNchr12:91545431chr10:17278293ENST00000441303-13282_3040.0173.0RepeatNote=LRR 10
HgeneDCNchr12:91545431chr10:17278293ENST00000441303-13305_3340.0173.0RepeatNote=LRR 11
HgeneDCNchr12:91545431chr10:17278293ENST00000441303-13335_3590.0173.0RepeatNote=LRR 12
HgeneDCNchr12:91545431chr10:17278293ENST00000441303-1373_930.0173.0RepeatNote=LRR 1
HgeneDCNchr12:91545431chr10:17278293ENST00000441303-1394_1170.0173.0RepeatNote=LRR 2
HgeneDCNchr12:91545431chr10:17278293ENST00000456569-12118_1410.076.0RepeatNote=LRR 3
HgeneDCNchr12:91545431chr10:17278293ENST00000456569-12142_1620.076.0RepeatNote=LRR 4
HgeneDCNchr12:91545431chr10:17278293ENST00000456569-12163_1860.076.0RepeatNote=LRR 5
HgeneDCNchr12:91545431chr10:17278293ENST00000456569-12187_2120.076.0RepeatNote=LRR 6
HgeneDCNchr12:91545431chr10:17278293ENST00000456569-12213_2330.076.0RepeatNote=LRR 7
HgeneDCNchr12:91545431chr10:17278293ENST00000456569-12234_2570.076.0RepeatNote=LRR 8
HgeneDCNchr12:91545431chr10:17278293ENST00000456569-12258_2810.076.0RepeatNote=LRR 9
HgeneDCNchr12:91545431chr10:17278293ENST00000456569-12282_3040.076.0RepeatNote=LRR 10
HgeneDCNchr12:91545431chr10:17278293ENST00000456569-12305_3340.076.0RepeatNote=LRR 11
HgeneDCNchr12:91545431chr10:17278293ENST00000456569-12335_3590.076.0RepeatNote=LRR 12
HgeneDCNchr12:91545431chr10:17278293ENST00000456569-1273_930.076.0RepeatNote=LRR 1
HgeneDCNchr12:91545431chr10:17278293ENST00000456569-1294_1170.076.0RepeatNote=LRR 2
HgeneDCNchr12:91545431chr10:17278293ENST00000547568-45142_162148.0213.0RepeatNote=LRR 4
HgeneDCNchr12:91545431chr10:17278293ENST00000547568-45163_186148.0213.0RepeatNote=LRR 5
HgeneDCNchr12:91545431chr10:17278293ENST00000547568-45187_212148.0213.0RepeatNote=LRR 6
HgeneDCNchr12:91545431chr10:17278293ENST00000547568-45213_233148.0213.0RepeatNote=LRR 7
HgeneDCNchr12:91545431chr10:17278293ENST00000547568-45234_257148.0213.0RepeatNote=LRR 8
HgeneDCNchr12:91545431chr10:17278293ENST00000547568-45258_281148.0213.0RepeatNote=LRR 9
HgeneDCNchr12:91545431chr10:17278293ENST00000547568-45282_304148.0213.0RepeatNote=LRR 10
HgeneDCNchr12:91545431chr10:17278293ENST00000547568-45305_334148.0213.0RepeatNote=LRR 11
HgeneDCNchr12:91545431chr10:17278293ENST00000547568-45335_359148.0213.0RepeatNote=LRR 12
HgeneDCNchr12:91545431chr10:17278293ENST00000552962-89282_304295.0360.0RepeatNote=LRR 10
HgeneDCNchr12:91545431chr10:17278293ENST00000552962-89305_334295.0360.0RepeatNote=LRR 11
HgeneDCNchr12:91545431chr10:17278293ENST00000552962-89335_359295.0360.0RepeatNote=LRR 12
TgeneVIMchr12:91545431chr10:17278293ENST0000022423769154_245424.3333333333333467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr12:91545431chr10:17278293ENST0000022423769303_407424.3333333333333467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr12:91545431chr10:17278293ENST000002242376996_131424.3333333333333467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr12:91545431chr10:17278293ENST00000544301710154_245424.3333333333333467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr12:91545431chr10:17278293ENST00000544301710303_407424.3333333333333467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr12:91545431chr10:17278293ENST0000054430171096_131424.3333333333333467.0Coiled coilOntology_term=ECO:0000269
TgeneVIMchr12:91545431chr10:17278293ENST0000022423769103_411424.3333333333333467.0DomainIF rod
TgeneVIMchr12:91545431chr10:17278293ENST00000544301710103_411424.3333333333333467.0DomainIF rod
TgeneVIMchr12:91545431chr10:17278293ENST0000022423769326_329424.3333333333333467.0Motif[IL]-x-C-x-x-[DE] motif
TgeneVIMchr12:91545431chr10:17278293ENST00000544301710326_329424.3333333333333467.0Motif[IL]-x-C-x-x-[DE] motif
TgeneVIMchr12:91545431chr10:17278293ENST0000022423769132_153424.3333333333333467.0RegionNote=Linker 1
TgeneVIMchr12:91545431chr10:17278293ENST0000022423769246_268424.3333333333333467.0RegionNote=Linker 12
TgeneVIMchr12:91545431chr10:17278293ENST0000022423769269_407424.3333333333333467.0RegionNote=Coil 2
TgeneVIMchr12:91545431chr10:17278293ENST00000224237692_95424.3333333333333467.0RegionNote=Head
TgeneVIMchr12:91545431chr10:17278293ENST0000022423769408_466424.3333333333333467.0RegionNote=Tail
TgeneVIMchr12:91545431chr10:17278293ENST00000544301710132_153424.3333333333333467.0RegionNote=Linker 1
TgeneVIMchr12:91545431chr10:17278293ENST00000544301710246_268424.3333333333333467.0RegionNote=Linker 12
TgeneVIMchr12:91545431chr10:17278293ENST00000544301710269_407424.3333333333333467.0RegionNote=Coil 2
TgeneVIMchr12:91545431chr10:17278293ENST000005443017102_95424.3333333333333467.0RegionNote=Head
TgeneVIMchr12:91545431chr10:17278293ENST00000544301710408_466424.3333333333333467.0RegionNote=Tail


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Fusion Gene Sequence for DCN-VIM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000393155_ENST00000544301_TCGA-BH-A0DL-11A_DCN_chr12_91545431_-_VIM_chr10_17278293_length(transcript)=1581nt_BP=1139nt
GGAATAATAAGACACGCCCTGAAGGAGTACATCGTCTAGTGAGGGACAGACCAAGCACGCAAAACAAATTGCAATATAATGTGATAAGTT
CTTTAAAAGAGGTAAGAGCAACGTGCTTTGGGAGCAGAGAAGAGGGAGAAAGCAGCATCTTGCCTGGATGAGCCAGGGGACACAGAAGAG
AAGCCCACTATCTCATTTAATCTTTACAACTCTCTTGCAAGGTTCCCTGGTTGTGAAAATACATGAGATAAATCATGAAGGCCACTATCA
TCCTCCTTCTGCTTGCACAAGTTTCCTGGGCTGGACCGTTTCAACAGAGAGGCTTATTTGACTTTATGCTAGAAGATGAGGCTTCTGGGA
TAGGCCCAGAAGTTCCTGATGACCGCGACTTCGAGCCCTCCCTAGGCCCAGTGTGCCCCTTCCGCTGTCAATGCCATCTTCGAGTGGTCC
AGTGTTCTGATTTGGGTCTGGACAAAGTGCCAAAGGATCTTCCCCCTGACACAACTCTGCTAGACCTGCAAAACAACAAAATAACCGAAA
TCAAAGATGGAGACTTTAAGAACCTGAAGAACCTTCACGCATTGATTCTTGTCAACAATAAAATTAGCAAAGTTAGTCCTGGAGCATTTA
CACCTTTGGTGAAGTTGGAACGACTTTATCTGTCCAAGAATCAGCTGAAGGAATTGCCAGAAAAAATGCCCAAAACTCTTCAGGAGCTGC
GTGCCCATGAGAATGAGATCACCAAAGTGCGAAAAGTTACTTTCAATGGACTGAACCAGATGATTGTCATAGAACTGGGCACCAATCCGC
TGAAGAGCTCAGGAATTGAAAATGGGGCTTTCCAGGGAATGAAGAAGCTCTCCTACATCCGCATTGCTGATACCAATATCACCAGCATTC
CTCAAGGTCTTCCTCCTTCCCTTACGGAATTACATCTTGATGGCAACAAAATCAGCAGAGTTGATGCAGCTAGCCTGAAAGGACTGAATA
ATTTGGCTAAGTTGGGATTGAGTTTCAACAGCATCTCTGCTGTTGACAATGGCTCTCTGGCCAACACGCCTCATCTGAGGGAGCTTCACT
TGGACAACAACAAGCTTACCAGAGTACCTGGTGGGCTGGCAGAGCATAAGTACATCCAGAAACTAATCTGGATTCACTCCCTCTGGTTGA
TACCCACTCAAAAAGGACACTTCTGATTAAGACGGTTGAAACTAGAGATGGACAGGTTATCAACGAAACTTCTCAGCATCACGATGACCT
TGAATAAAAATTGCACACACTCAGTGCAGCAATATATTACCAGCAAGAATAAAAAAGAAATCCATATCTTAAAGAAACAGCTTTCAAGTG
CCTTTCTGCAGTTTTTCAGGAGCGCAAGATAGATTTGGAATAGGAATAAGCTCTAGTTCTTAACAACCGACACTCCTACAAGATTTAGAA
AAAAGTTTACAACATAATCTAGTTTACAGAAAAATCTTGTGCTAGAATACTTTTTAAAAGGTATTTTGAATACCATTAAAACTGCTTTTT

>In-frame_ENST00000393155_ENST00000544301_TCGA-BH-A0DL-11A_DCN_chr12_91545431_-_VIM_chr10_17278293_length(amino acids)=313AA_start in transcript=254_stop in transcript=1195
MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQN
NKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIE
LGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPH

--------------------------------------------------------------
>In-frame_ENST00000393155_ENST00000224237_TCGA-BH-A0DL-11A_DCN_chr12_91545431_-_VIM_chr10_17278293_length(transcript)=1589nt_BP=1139nt
GGAATAATAAGACACGCCCTGAAGGAGTACATCGTCTAGTGAGGGACAGACCAAGCACGCAAAACAAATTGCAATATAATGTGATAAGTT
CTTTAAAAGAGGTAAGAGCAACGTGCTTTGGGAGCAGAGAAGAGGGAGAAAGCAGCATCTTGCCTGGATGAGCCAGGGGACACAGAAGAG
AAGCCCACTATCTCATTTAATCTTTACAACTCTCTTGCAAGGTTCCCTGGTTGTGAAAATACATGAGATAAATCATGAAGGCCACTATCA
TCCTCCTTCTGCTTGCACAAGTTTCCTGGGCTGGACCGTTTCAACAGAGAGGCTTATTTGACTTTATGCTAGAAGATGAGGCTTCTGGGA
TAGGCCCAGAAGTTCCTGATGACCGCGACTTCGAGCCCTCCCTAGGCCCAGTGTGCCCCTTCCGCTGTCAATGCCATCTTCGAGTGGTCC
AGTGTTCTGATTTGGGTCTGGACAAAGTGCCAAAGGATCTTCCCCCTGACACAACTCTGCTAGACCTGCAAAACAACAAAATAACCGAAA
TCAAAGATGGAGACTTTAAGAACCTGAAGAACCTTCACGCATTGATTCTTGTCAACAATAAAATTAGCAAAGTTAGTCCTGGAGCATTTA
CACCTTTGGTGAAGTTGGAACGACTTTATCTGTCCAAGAATCAGCTGAAGGAATTGCCAGAAAAAATGCCCAAAACTCTTCAGGAGCTGC
GTGCCCATGAGAATGAGATCACCAAAGTGCGAAAAGTTACTTTCAATGGACTGAACCAGATGATTGTCATAGAACTGGGCACCAATCCGC
TGAAGAGCTCAGGAATTGAAAATGGGGCTTTCCAGGGAATGAAGAAGCTCTCCTACATCCGCATTGCTGATACCAATATCACCAGCATTC
CTCAAGGTCTTCCTCCTTCCCTTACGGAATTACATCTTGATGGCAACAAAATCAGCAGAGTTGATGCAGCTAGCCTGAAAGGACTGAATA
ATTTGGCTAAGTTGGGATTGAGTTTCAACAGCATCTCTGCTGTTGACAATGGCTCTCTGGCCAACACGCCTCATCTGAGGGAGCTTCACT
TGGACAACAACAAGCTTACCAGAGTACCTGGTGGGCTGGCAGAGCATAAGTACATCCAGAAACTAATCTGGATTCACTCCCTCTGGTTGA
TACCCACTCAAAAAGGACACTTCTGATTAAGACGGTTGAAACTAGAGATGGACAGGTTATCAACGAAACTTCTCAGCATCACGATGACCT
TGAATAAAAATTGCACACACTCAGTGCAGCAATATATTACCAGCAAGAATAAAAAAGAAATCCATATCTTAAAGAAACAGCTTTCAAGTG
CCTTTCTGCAGTTTTTCAGGAGCGCAAGATAGATTTGGAATAGGAATAAGCTCTAGTTCTTAACAACCGACACTCCTACAAGATTTAGAA
AAAAGTTTACAACATAATCTAGTTTACAGAAAAATCTTGTGCTAGAATACTTTTTAAAAGGTATTTTGAATACCATTAAAACTGCTTTTT

>In-frame_ENST00000393155_ENST00000224237_TCGA-BH-A0DL-11A_DCN_chr12_91545431_-_VIM_chr10_17278293_length(amino acids)=313AA_start in transcript=254_stop in transcript=1195
MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQN
NKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIE
LGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DCN-VIM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DCN-VIM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DCN-VIM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDCNC1864738Corneal Dystrophy, Congenital Stromal2CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneDCNC0014170Endometrial Neoplasms1CTD_human
HgeneDCNC0016059Fibrosis1CTD_human
HgeneDCNC0027707Nephritis, Interstitial1CTD_human
HgeneDCNC0041349Nephritis, Tubulointerstitial1CTD_human
HgeneDCNC0151744Myocardial Ischemia1CTD_human
HgeneDCNC0238288Muscular Dystrophy, Facioscapulohumeral1CTD_human
HgeneDCNC0476089Endometrial Carcinoma1CTD_human
HgeneDCNC1623038Cirrhosis1CTD_human
HgeneDCNC2239176Liver carcinoma1CTD_human
TgeneVIMC0006142Malignant neoplasm of breast4CTD_human
TgeneVIMC0678222Breast Carcinoma4CTD_human
TgeneVIMC1257931Mammary Neoplasms, Human4CTD_human
TgeneVIMC1458155Mammary Neoplasms4CTD_human
TgeneVIMC3805411CATARACT 304GENOMICS_ENGLAND;UNIPROT
TgeneVIMC4704874Mammary Carcinoma, Human4CTD_human
TgeneVIMC0023890Liver Cirrhosis2CTD_human
TgeneVIMC0029408Degenerative polyarthritis2CTD_human
TgeneVIMC0033578Prostatic Neoplasms2CTD_human
TgeneVIMC0086743Osteoarthrosis Deformans2CTD_human
TgeneVIMC0239946Fibrosis, Liver2CTD_human
TgeneVIMC0376358Malignant neoplasm of prostate2CTD_human
TgeneVIMC0007140Carcinosarcoma1CTD_human
TgeneVIMC0007621Neoplastic Cell Transformation1CTD_human
TgeneVIMC0019193Hepatitis, Toxic1CTD_human
TgeneVIMC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneVIMC0027626Neoplasm Invasiveness1CTD_human
TgeneVIMC0027627Neoplasm Metastasis1CTD_human
TgeneVIMC0027720Nephrosis1CTD_human
TgeneVIMC0031149Peritoneal Neoplasms1CTD_human
TgeneVIMC0035126Reperfusion Injury1CTD_human
TgeneVIMC0035309Retinal Diseases1CTD_human
TgeneVIMC0039101synovial sarcoma1CTD_human
TgeneVIMC0043094Weight Gain1CTD_human
TgeneVIMC0085084Motor Neuron Disease1CTD_human
TgeneVIMC0086543Cataract1CTD_human
TgeneVIMC0154681Anterior Horn Cell Disease1CTD_human
TgeneVIMC0154682Lateral Sclerosis1CTD_human
TgeneVIMC0270715Degenerative Diseases, Central Nervous System1CTD_human
TgeneVIMC0270763Familial Motor Neuron Disease1CTD_human
TgeneVIMC0270764Motor Neuron Disease, Lower1CTD_human
TgeneVIMC0345967Malignant mesothelioma1CTD_human
TgeneVIMC0346990Carcinomatosis of peritoneal cavity1CTD_human
TgeneVIMC0521659Motor Neuron Disease, Upper1CTD_human
TgeneVIMC0524524Pseudoaphakia1CTD_human
TgeneVIMC0524851Neurodegenerative Disorders1CTD_human
TgeneVIMC0543858Motor Neuron Disease, Secondary1CTD_human
TgeneVIMC0751733Degenerative Diseases, Spinal Cord1CTD_human
TgeneVIMC0860207Drug-Induced Liver Disease1CTD_human
TgeneVIMC0948089Acute Coronary Syndrome1CTD_human
TgeneVIMC1262760Hepatitis, Drug-Induced1CTD_human
TgeneVIMC1510497Lens Opacities1CTD_human
TgeneVIMC1833118Cataract, Pulverulent1ORPHANET
TgeneVIMC1852438CATARACT, COPPOCK-LIKE1ORPHANET
TgeneVIMC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
TgeneVIMC1862941Amyotrophic Lateral Sclerosis, Sporadic1CTD_human
TgeneVIMC3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneVIMC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneVIMC4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneVIMC4551993Amyotrophic Lateral Sclerosis, Familial1CTD_human