|
Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:DCPS-CCND1 (FusionGDB2 ID:21649) |
Fusion Gene Summary for DCPS-CCND1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: DCPS-CCND1 | Fusion gene ID: 21649 | Hgene | Tgene | Gene symbol | DCPS | CCND1 | Gene ID | 28960 | 595 |
Gene name | decapping enzyme, scavenger | cyclin D1 | |
Synonyms | ARS|DCS1|HINT-5|HINT5|HSL1|HSPC015 | BCL1|D11S287E|PRAD1|U21B31 | |
Cytomap | 11q24.2 | 11q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | m7GpppX diphosphatase5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatasedecapping scavenger enzymeepididymis secretory sperm binding proteinheat shock-like protein 1hint-related 7meGMP-directed hydrolasehistidine triad nucleotide-binding pr | G1/S-specific cyclin-D1B-cell CLL/lymphoma 1B-cell lymphoma 1 proteinBCL-1 oncogenePRAD1 oncogene | |
Modification date | 20200313 | 20200327 | |
UniProtAcc | Q96C86 | P24385 | |
Ensembl transtripts involved in fusion gene | ENST00000263579, ENST00000530860, | ENST00000227507, ENST00000536559, | |
Fusion gene scores | * DoF score | 5 X 3 X 3=45 | 15 X 16 X 5=1200 |
# samples | 5 | 16 | |
** MAII score | log2(5/45*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(16/1200*10)=-2.90689059560852 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DCPS [Title/Abstract] AND CCND1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | DCPS(126176639)-CCND1(69462761), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | DCPS-CCND1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. DCPS-CCND1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. DCPS-CCND1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. DCPS-CCND1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DCPS | GO:0036245 | cellular response to menadione | 16140270 |
Hgene | DCPS | GO:0043069 | negative regulation of programmed cell death | 16140270 |
Hgene | DCPS | GO:0045292 | mRNA cis splicing, via spliceosome | 18426921 |
Tgene | CCND1 | GO:0000082 | G1/S transition of mitotic cell cycle | 19412162 |
Tgene | CCND1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 16569215|18417529 |
Tgene | CCND1 | GO:0001934 | positive regulation of protein phosphorylation | 8114739 |
Tgene | CCND1 | GO:0006974 | cellular response to DNA damage stimulus | 19412162 |
Tgene | CCND1 | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle | 19124461 |
Tgene | CCND1 | GO:0031571 | mitotic G1 DNA damage checkpoint | 19412162 |
Tgene | CCND1 | GO:0044321 | response to leptin | 17344214 |
Tgene | CCND1 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity | 8114739 |
Tgene | CCND1 | GO:0070141 | response to UV-A | 18483258 |
Tgene | CCND1 | GO:0071157 | negative regulation of cell cycle arrest | 19124461 |
Fusion gene breakpoints across DCPS (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across CCND1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | ESCA | TCGA-IG-A3I8-01A | DCPS | chr11 | 126176639 | + | CCND1 | chr11 | 69462762 | + |
ChimerDB4 | ESCA | TCGA-IG-A3I8 | DCPS | chr11 | 126176639 | + | CCND1 | chr11 | 69462761 | + |
ChimerDB4 | ESCA | TCGA-IG-A3I8 | DCPS | chr11 | 126176639 | + | CCND1 | chr11 | 69457798 | + |
ChimerDB4 | ESCA | TCGA-IG-A3I8 | DCPS | chr11 | 126176639 | + | CCND1 | chr11 | 69462761 | + |
Top |
Fusion Gene ORF analysis for DCPS-CCND1 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000263579 | ENST00000227507 | DCPS | chr11 | 126176639 | + | CCND1 | chr11 | 69462762 | + |
Frame-shift | ENST00000263579 | ENST00000536559 | DCPS | chr11 | 126176639 | + | CCND1 | chr11 | 69462762 | + |
intron-3CDS | ENST00000530860 | ENST00000227507 | DCPS | chr11 | 126176639 | + | CCND1 | chr11 | 69462762 | + |
intron-3CDS | ENST00000530860 | ENST00000536559 | DCPS | chr11 | 126176639 | + | CCND1 | chr11 | 69462762 | + |
In-frame | ENST00000263579 | ENST00000227507 | DCPS | chr11 | 126176639 | + | CCND1 | chr11 | 69462761 | + |
Frame-shift | ENST00000263579 | ENST00000536559 | DCPS | chr11 | 126176639 | + | CCND1 | chr11 | 69462761 | + |
intron-3CDS | ENST00000530860 | ENST00000227507 | DCPS | chr11 | 126176639 | + | CCND1 | chr11 | 69462761 | + |
intron-3CDS | ENST00000530860 | ENST00000536559 | DCPS | chr11 | 126176639 | + | CCND1 | chr11 | 69462761 | + |
Frame-shift | ENST00000263579 | ENST00000227507 | DCPS | chr11 | 126176639 | + | CCND1 | chr11 | 69457798 | + |
5CDS-intron | ENST00000263579 | ENST00000536559 | DCPS | chr11 | 126176639 | + | CCND1 | chr11 | 69457798 | + |
intron-3CDS | ENST00000530860 | ENST00000227507 | DCPS | chr11 | 126176639 | + | CCND1 | chr11 | 69457798 | + |
intron-intron | ENST00000530860 | ENST00000536559 | DCPS | chr11 | 126176639 | + | CCND1 | chr11 | 69457798 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000263579 | DCPS | chr11 | 126176639 | + | ENST00000227507 | CCND1 | chr11 | 69462762 | + | 4211 | 705 | 107 | 1018 | 303 |
ENST00000263579 | DCPS | chr11 | 126176639 | + | ENST00000227507 | CCND1 | chr11 | 69462761 | + | 4211 | 705 | 107 | 1018 | 303 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000263579 | ENST00000227507 | DCPS | chr11 | 126176639 | + | CCND1 | chr11 | 69462762 | + | 0.000255026 | 0.99974495 |
ENST00000263579 | ENST00000227507 | DCPS | chr11 | 126176639 | + | CCND1 | chr11 | 69462761 | + | 0.000255026 | 0.99974495 |
Top |
Fusion Genomic Features for DCPS-CCND1 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
DCPS | chr11 | 126176639 | + | CCND1 | chr11 | 69457798 | + | 0.003544909 | 0.9964551 |
DCPS | chr11 | 126176639 | + | CCND1 | chr11 | 69462761 | + | 8.88E-08 | 0.9999999 |
DCPS | chr11 | 126176639 | + | CCND1 | chr11 | 69462761 | + | 8.88E-08 | 0.9999999 |
DCPS | chr11 | 126176639 | + | CCND1 | chr11 | 69457798 | + | 0.003544909 | 0.9964551 |
DCPS | chr11 | 126176639 | + | CCND1 | chr11 | 69462761 | + | 8.88E-08 | 0.9999999 |
DCPS | chr11 | 126176639 | + | CCND1 | chr11 | 69462761 | + | 8.88E-08 | 0.9999999 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
Top |
Fusion Protein Features for DCPS-CCND1 |
Go to FGviewer for the breakpoints of chr11:126176639-chr11:69462762 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
DCPS | CCND1 |
FUNCTION: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP (PubMed:22985415). May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP (PubMed:14523240). Binds to m7GpppG and strongly to m7GDP. Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death. {ECO:0000269|PubMed:11747811, ECO:0000269|PubMed:12198172, ECO:0000269|PubMed:12871939, ECO:0000269|PubMed:14523240, ECO:0000269|PubMed:15273322, ECO:0000269|PubMed:15383679, ECO:0000269|PubMed:15769464, ECO:0000269|PubMed:16140270, ECO:0000269|PubMed:18426921, ECO:0000269|PubMed:22985415}. | FUNCTION: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner. {ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:16569215, ECO:0000269|PubMed:18417529, ECO:0000269|PubMed:9106657}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | CCND1 | chr11:126176639 | chr11:69462761 | ENST00000227507 | 2 | 5 | 272_280 | 191.33333333333334 | 296.0 | Compositional bias | Note=Poly-Glu | |
Tgene | CCND1 | chr11:126176639 | chr11:69462762 | ENST00000227507 | 2 | 5 | 272_280 | 191.33333333333334 | 296.0 | Compositional bias | Note=Poly-Glu |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | DCPS | chr11:126176639 | chr11:69462761 | ENST00000263579 | + | 2 | 6 | 142_154 | 125.33333333333333 | 338.0 | Motif | Note=nuclear export sequence (NES) |
Hgene | DCPS | chr11:126176639 | chr11:69462761 | ENST00000263579 | + | 2 | 6 | 275_279 | 125.33333333333333 | 338.0 | Motif | Note=Histidine triad motif |
Hgene | DCPS | chr11:126176639 | chr11:69462762 | ENST00000263579 | + | 2 | 6 | 142_154 | 125.33333333333333 | 338.0 | Motif | Note=nuclear export sequence (NES) |
Hgene | DCPS | chr11:126176639 | chr11:69462762 | ENST00000263579 | + | 2 | 6 | 275_279 | 125.33333333333333 | 338.0 | Motif | Note=Histidine triad motif |
Hgene | DCPS | chr11:126176639 | chr11:69462761 | ENST00000263579 | + | 2 | 6 | 268_279 | 125.33333333333333 | 338.0 | Region | Note=Substrate binding |
Hgene | DCPS | chr11:126176639 | chr11:69462762 | ENST00000263579 | + | 2 | 6 | 268_279 | 125.33333333333333 | 338.0 | Region | Note=Substrate binding |
Tgene | CCND1 | chr11:126176639 | chr11:69462761 | ENST00000227507 | 2 | 5 | 28_152 | 191.33333333333334 | 296.0 | Domain | Note=Cyclin N-terminal | |
Tgene | CCND1 | chr11:126176639 | chr11:69462762 | ENST00000227507 | 2 | 5 | 28_152 | 191.33333333333334 | 296.0 | Domain | Note=Cyclin N-terminal |
Top |
Fusion Gene Sequence for DCPS-CCND1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000263579_ENST00000227507_TCGA-IG-A3I8-01A_DCPS_chr11_126176639_+_CCND1_chr11_69462762_length(transcript)=4211nt_BP=705nt GGGCGTCTTCGGCTCCCACCCCGGGGCGTGGGCCTGGGGGTCCCTCTTCACTGCGCAGCCACCTCTAGCCCGCCGCTTTCGGGACTCTCA GCCTTCTTTTCCCTTCCCTGAGGGCCGGCCGGCACCACAACGGGGCCAAAGGCAGTAACTCGGTTGAAAGGCGCGCCCTGGGACAGGTCA GCGGGCTCCGCCATGCGCGGCACGCATCCCGCAGGAGCGGGTGCCAGAGCAGGGTAGGCCGGGAGTTAGCAGCCCAGCCAGGCCGCTGGA CTCGGGCTAGGGGCGGGGCCAGCGCAGGGGGCGCAGGCGCACACCGCCTCCGCGGCAGCATGGCGGACGCAGCTCCTCAACTAGGCAAGA GGAAGCGCGAATTGGACGTGGAGGAGGCCCACGCCGCCAGCACAGAGGAAAAGGAGGCAGGAGTTGGAAATGGTACCTGTGCTCCTGTCC GCTTACCGTTCTCCGGCTTCAGACTGCAGAAGGTGCTGAGGGAGTCTGCGCGGGACAAAATCATTTTCCTACACGGGAAGGTGAATGAGG CCTCTGGGGATGGGGATGGAGAGGATGCCGTTGTGATCCTGGAGAAGACGCCATTTCAGGTGGAACAGGTGGCTCAGCTCCTGACGGGCA GCCCTGAGCTCCAGTTGCAGTTCTCCAATGATATCTACAGCACCTATCACTTGTTCCCTCCAAGACAACTGAATGATGTGAAGTTCATTT CCAATCCGCCCTCCATGGTGGCAGCGGGGAGCGTGGTGGCCGCAGTGCAAGGCCTGAACCTGAGGAGCCCCAACAACTTCCTGTCCTACT ACCGCCTCACACGCTTCCTCTCCAGAGTGATCAAGTGTGACCCGGACTGCCTCCGGGCCTGCCAGGAGCAGATCGAAGCCCTGCTGGAGT CAAGCCTGCGCCAGGCCCAGCAGAACATGGACCCCAAGGCCGCCGAGGAGGAGGAAGAGGAGGAGGAGGAGGTGGACCTGGCTTGCACAC CCACCGACGTGCGGGACGTGGACATCTGAGGGCGCCAGGCAGGCGGGCGCCACCGCCACCCGCAGCGAGGGCGGAGCCGGCCCCAGGTGC TCCCCTGACAGTCCCTCCTCTCCGGAGCATTTTGATACCAGAAGGGAAAGCTTCATTCTCCTTGTTGTTGGTTGTTTTTTCCTTTGCTCT TTCCCCCTTCCATCTCTGACTTAAGCAAAAGAAAAAGATTACCCAAAAACTGTCTTTAAAAGAGAGAGAGAGAAAAAAAAAATAGTATTT GCATAACCCTGAGCGGTGGGGGAGGAGGGTTGTGCTACAGATGATAGAGGATTTTATACCCCAATAATCAACTCGTTTTTATATTAATGT ACTTGTTTCTCTGTTGTAAGAATAGGCATTAACACAAAGGAGGCGTCTCGGGAGAGGATTAGGTTCCATCCTTTACGTGTTTAAAAAAAA GCATAAAAACATTTTAAAAACATAGAAAAATTCAGCAAACCATTTTTAAAGTAGAAGAGGGTTTTAGGTAGAAAAACATATTCTTGTGCT TTTCCTGATAAAGCACAGCTGTAGTGGGGTTCTAGGCATCTCTGTACTTTGCTTGCTCATATGCATGTAGTCACTTTATAAGTCATTGTA TGTTATTATATTCCGTAGGTAGATGTGTAACCTCTTCACCTTATTCATGGCTGAAGTCACCTCTTGGTTACAGTAGCGTAGCGTGCCCGT GTGCATGTCCTTTGCGCCTGTGACCACCACCCCAACAAACCATCCAGTGACAAACCATCCAGTGGAGGTTTGTCGGGCACCAGCCAGCGT AGCAGGGTCGGGAAAGGCCACCTGTCCCACTCCTACGATACGCTACTATAAAGAGAAGACGAAATAGTGACATAATATATTCTATTTTTA TACTCTTCCTATTTTTGTAGTGACCTGTTTATGAGATGCTGGTTTTCTACCCAACGGCCCTGCAGCCAGCTCACGTCCAGGTTCAACCCA CAGCTACTTGGTTTGTGTTCTTCTTCATATTCTAAAACCATTCCATTTCCAAGCACTTTCAGTCCAATAGGTGTAGGAAATAGCGCTGTT TTTGTTGTGTGTGCAGGGAGGGCAGTTTTCTAATGGAATGGTTTGGGAATATCCATGTACTTGTTTGCAAGCAGGACTTTGAGGCAAGTG TGGGCCACTGTGGTGGCAGTGGAGGTGGGGTGTTTGGGAGGCTGCGTGCCAGTCAAGAAGAAAAAGGTTTGCATTCTCACATTGCCAGGA TGATAAGTTCCTTTCCTTTTCTTTAAAGAAGTTGAAGTTTAGGAATCCTTTGGTGCCAACTGGTGTTTGAAAGTAGGGACCTCAGAGGTT TACCTAGAGAACAGGTGGTTTTTAAGGGTTATCTTAGATGTTTCACACCGGAAGGTTTTTAAACACTAAAATATATAATTTATAGTTAAG GCTAAAAAGTATATTTATTGCAGAGGATGTTCATAAGGCCAGTATGATTTATAAATGCAATCTCCCCTTGATTTAAACACACAGATACAC ACACACACACACACACACACAAACCTTCTGCCTTTGATGTTACAGATTTAATACAGTTTATTTTTAAAGATAGATCCTTTTATAGGTGAG AAAAAAACAATCTGGAAGAAAAAAACCACACAAAGACATTGATTCAGCCTGTTTGGCGTTTCCCAGAGTCATCTGATTGGACAGGCATGG GTGCAAGGAAAATTAGGGTACTCAACCTAAGTTCGGTTCCGATGAATTCTTATCCCCTGCCCCTTCCTTTAAAAAACTTAGTGACAAAAT AGACAATTTGCACATCTTGGCTATGTAATTCTTGTAATTTTTATTTAGGAAGTGTTGAAGGGAGGTGGCAAGAGTGTGGAGGCTGACGTG TGAGGGAGGACAGGCGGGAGGAGGTGTGAGGAGGAGGCTCCCGAGGGGAAGGGGCGGTGCCCACACCGGGGACAGGCCGCAGCTCCATTT TCTTATTGCGCTGCTACCGTTGACTTCCAGGCACGGTTTGGAAATATTCACATCGCTTCTGTGTATCTCTTTCACATTGTTTGCTGCTAT TGGAGGATCAGTTTTTTGTTTTACAATGTCATATACTGCCATGTACTAGTTTTAGTTTTCTCTTAGAACATTGTATTACAGATGCCTTTT TTGTAGTTTTTTTTTTTTTTATGTGATCAATTTTGACTTAATGTGATTACTGCTCTATTCCAAAAAGGTTGCTGTTTCACAATACCTCAT GCTTCACTTAGCCATGGTGGACCCAGCGGGCAGGTTCTGCCTGCTTTGGCGGGCAGACACGCGGGCGCGATCCCACACAGGCTGGCGGGG GCCGGCCCCGAGGCCGCGTGCGTGAGAACCGCGCCGGTGTCCCCAGAGACCAGGCTGTGTCCCTCTTCTCTTCCCTGCGCCTGTGATGCT GGGCACTTCATCTGATCGGGGGCGTAGCATCATAGTAGTTTTTACAGCTGTGTTATTCTTTGCGTGTAGCTATGGAAGTTGCATAATTAT TATTATTATTATTATAACAAGTGTGTCTTACGTGCCACCACGGCGTTGTACCTGTAGGACTCTCATTCGGGATGATTGGAATAGCTTCTG GAATTTGTTCAAGTTTTGGGTATGTTTAATCTGTTATGTACTAGTGTTCTGTTTGTTATTGTTTTGTTAATTACACCATAATGCTAATTT AAAGAGACTCCAAATCTCAATGAAGCCAGCTCACAGTGCTGTGTGCCCCGGTCACCTAGCAAGCTGCCGAACCAAAAGAATTTGCACCCC GCTGCGGGCCCACGTGGTTGGGGCCCTGCCCTGGCAGGGTCATCCTGTGCTCGGAGGCCATCTCGGGCACAGGCCCACCCCGCCCCACCC CTCCAGAACACGGCTCACGCTTACCTCAACCATCCTGGCTGCGGCGTCTGTCTGAACCACGCGGGGGCCTTGAGGGACGCTTTGTCTGTC GTGATGGGGCAAGGGCACAAGTCCTGGATGTTGTGTGTATCGAGAGGCCAAAGGCTGGTGGCAAGTGCACGGGGCACAGCGGAGTCTGTC CTGTGACGCGCAAGTCTGAGGGTCTGGGCGGCGGGCGGCTGGGTCTGTGCATTTCTGGTTGCACCGCGGCGCTTCCCAGCACCAACATGT >In-frame_ENST00000263579_ENST00000227507_TCGA-IG-A3I8-01A_DCPS_chr11_126176639_+_CCND1_chr11_69462762_length(amino acids)=303AA_start in transcript=107_stop in transcript=1018 MRAGRHHNGAKGSNSVERRALGQVSGLRHARHASRRSGCQSRVGRELAAQPGRWTRARGGASAGGAGAHRLRGSMADAAPQLGKRKRELD VEEAHAASTEEKEAGVGNGTCAPVRLPFSGFRLQKVLRESARDKIIFLHGKVNEASGDGDGEDAVVILEKTPFQVEQVAQLLTGSPELQL QFSNDIYSTYHLFPPRQLNDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCDPDCLRACQEQIEALLESSLRQA -------------------------------------------------------------- >In-frame_ENST00000263579_ENST00000227507_TCGA-IG-A3I8_DCPS_chr11_126176639_+_CCND1_chr11_69462761_length(transcript)=4211nt_BP=705nt GGGCGTCTTCGGCTCCCACCCCGGGGCGTGGGCCTGGGGGTCCCTCTTCACTGCGCAGCCACCTCTAGCCCGCCGCTTTCGGGACTCTCA GCCTTCTTTTCCCTTCCCTGAGGGCCGGCCGGCACCACAACGGGGCCAAAGGCAGTAACTCGGTTGAAAGGCGCGCCCTGGGACAGGTCA GCGGGCTCCGCCATGCGCGGCACGCATCCCGCAGGAGCGGGTGCCAGAGCAGGGTAGGCCGGGAGTTAGCAGCCCAGCCAGGCCGCTGGA CTCGGGCTAGGGGCGGGGCCAGCGCAGGGGGCGCAGGCGCACACCGCCTCCGCGGCAGCATGGCGGACGCAGCTCCTCAACTAGGCAAGA GGAAGCGCGAATTGGACGTGGAGGAGGCCCACGCCGCCAGCACAGAGGAAAAGGAGGCAGGAGTTGGAAATGGTACCTGTGCTCCTGTCC GCTTACCGTTCTCCGGCTTCAGACTGCAGAAGGTGCTGAGGGAGTCTGCGCGGGACAAAATCATTTTCCTACACGGGAAGGTGAATGAGG CCTCTGGGGATGGGGATGGAGAGGATGCCGTTGTGATCCTGGAGAAGACGCCATTTCAGGTGGAACAGGTGGCTCAGCTCCTGACGGGCA GCCCTGAGCTCCAGTTGCAGTTCTCCAATGATATCTACAGCACCTATCACTTGTTCCCTCCAAGACAACTGAATGATGTGAAGTTCATTT CCAATCCGCCCTCCATGGTGGCAGCGGGGAGCGTGGTGGCCGCAGTGCAAGGCCTGAACCTGAGGAGCCCCAACAACTTCCTGTCCTACT ACCGCCTCACACGCTTCCTCTCCAGAGTGATCAAGTGTGACCCGGACTGCCTCCGGGCCTGCCAGGAGCAGATCGAAGCCCTGCTGGAGT CAAGCCTGCGCCAGGCCCAGCAGAACATGGACCCCAAGGCCGCCGAGGAGGAGGAAGAGGAGGAGGAGGAGGTGGACCTGGCTTGCACAC CCACCGACGTGCGGGACGTGGACATCTGAGGGCGCCAGGCAGGCGGGCGCCACCGCCACCCGCAGCGAGGGCGGAGCCGGCCCCAGGTGC TCCCCTGACAGTCCCTCCTCTCCGGAGCATTTTGATACCAGAAGGGAAAGCTTCATTCTCCTTGTTGTTGGTTGTTTTTTCCTTTGCTCT TTCCCCCTTCCATCTCTGACTTAAGCAAAAGAAAAAGATTACCCAAAAACTGTCTTTAAAAGAGAGAGAGAGAAAAAAAAAATAGTATTT GCATAACCCTGAGCGGTGGGGGAGGAGGGTTGTGCTACAGATGATAGAGGATTTTATACCCCAATAATCAACTCGTTTTTATATTAATGT ACTTGTTTCTCTGTTGTAAGAATAGGCATTAACACAAAGGAGGCGTCTCGGGAGAGGATTAGGTTCCATCCTTTACGTGTTTAAAAAAAA GCATAAAAACATTTTAAAAACATAGAAAAATTCAGCAAACCATTTTTAAAGTAGAAGAGGGTTTTAGGTAGAAAAACATATTCTTGTGCT TTTCCTGATAAAGCACAGCTGTAGTGGGGTTCTAGGCATCTCTGTACTTTGCTTGCTCATATGCATGTAGTCACTTTATAAGTCATTGTA TGTTATTATATTCCGTAGGTAGATGTGTAACCTCTTCACCTTATTCATGGCTGAAGTCACCTCTTGGTTACAGTAGCGTAGCGTGCCCGT GTGCATGTCCTTTGCGCCTGTGACCACCACCCCAACAAACCATCCAGTGACAAACCATCCAGTGGAGGTTTGTCGGGCACCAGCCAGCGT AGCAGGGTCGGGAAAGGCCACCTGTCCCACTCCTACGATACGCTACTATAAAGAGAAGACGAAATAGTGACATAATATATTCTATTTTTA TACTCTTCCTATTTTTGTAGTGACCTGTTTATGAGATGCTGGTTTTCTACCCAACGGCCCTGCAGCCAGCTCACGTCCAGGTTCAACCCA CAGCTACTTGGTTTGTGTTCTTCTTCATATTCTAAAACCATTCCATTTCCAAGCACTTTCAGTCCAATAGGTGTAGGAAATAGCGCTGTT TTTGTTGTGTGTGCAGGGAGGGCAGTTTTCTAATGGAATGGTTTGGGAATATCCATGTACTTGTTTGCAAGCAGGACTTTGAGGCAAGTG TGGGCCACTGTGGTGGCAGTGGAGGTGGGGTGTTTGGGAGGCTGCGTGCCAGTCAAGAAGAAAAAGGTTTGCATTCTCACATTGCCAGGA TGATAAGTTCCTTTCCTTTTCTTTAAAGAAGTTGAAGTTTAGGAATCCTTTGGTGCCAACTGGTGTTTGAAAGTAGGGACCTCAGAGGTT TACCTAGAGAACAGGTGGTTTTTAAGGGTTATCTTAGATGTTTCACACCGGAAGGTTTTTAAACACTAAAATATATAATTTATAGTTAAG GCTAAAAAGTATATTTATTGCAGAGGATGTTCATAAGGCCAGTATGATTTATAAATGCAATCTCCCCTTGATTTAAACACACAGATACAC ACACACACACACACACACACAAACCTTCTGCCTTTGATGTTACAGATTTAATACAGTTTATTTTTAAAGATAGATCCTTTTATAGGTGAG AAAAAAACAATCTGGAAGAAAAAAACCACACAAAGACATTGATTCAGCCTGTTTGGCGTTTCCCAGAGTCATCTGATTGGACAGGCATGG GTGCAAGGAAAATTAGGGTACTCAACCTAAGTTCGGTTCCGATGAATTCTTATCCCCTGCCCCTTCCTTTAAAAAACTTAGTGACAAAAT AGACAATTTGCACATCTTGGCTATGTAATTCTTGTAATTTTTATTTAGGAAGTGTTGAAGGGAGGTGGCAAGAGTGTGGAGGCTGACGTG TGAGGGAGGACAGGCGGGAGGAGGTGTGAGGAGGAGGCTCCCGAGGGGAAGGGGCGGTGCCCACACCGGGGACAGGCCGCAGCTCCATTT TCTTATTGCGCTGCTACCGTTGACTTCCAGGCACGGTTTGGAAATATTCACATCGCTTCTGTGTATCTCTTTCACATTGTTTGCTGCTAT TGGAGGATCAGTTTTTTGTTTTACAATGTCATATACTGCCATGTACTAGTTTTAGTTTTCTCTTAGAACATTGTATTACAGATGCCTTTT TTGTAGTTTTTTTTTTTTTTATGTGATCAATTTTGACTTAATGTGATTACTGCTCTATTCCAAAAAGGTTGCTGTTTCACAATACCTCAT GCTTCACTTAGCCATGGTGGACCCAGCGGGCAGGTTCTGCCTGCTTTGGCGGGCAGACACGCGGGCGCGATCCCACACAGGCTGGCGGGG GCCGGCCCCGAGGCCGCGTGCGTGAGAACCGCGCCGGTGTCCCCAGAGACCAGGCTGTGTCCCTCTTCTCTTCCCTGCGCCTGTGATGCT GGGCACTTCATCTGATCGGGGGCGTAGCATCATAGTAGTTTTTACAGCTGTGTTATTCTTTGCGTGTAGCTATGGAAGTTGCATAATTAT TATTATTATTATTATAACAAGTGTGTCTTACGTGCCACCACGGCGTTGTACCTGTAGGACTCTCATTCGGGATGATTGGAATAGCTTCTG GAATTTGTTCAAGTTTTGGGTATGTTTAATCTGTTATGTACTAGTGTTCTGTTTGTTATTGTTTTGTTAATTACACCATAATGCTAATTT AAAGAGACTCCAAATCTCAATGAAGCCAGCTCACAGTGCTGTGTGCCCCGGTCACCTAGCAAGCTGCCGAACCAAAAGAATTTGCACCCC GCTGCGGGCCCACGTGGTTGGGGCCCTGCCCTGGCAGGGTCATCCTGTGCTCGGAGGCCATCTCGGGCACAGGCCCACCCCGCCCCACCC CTCCAGAACACGGCTCACGCTTACCTCAACCATCCTGGCTGCGGCGTCTGTCTGAACCACGCGGGGGCCTTGAGGGACGCTTTGTCTGTC GTGATGGGGCAAGGGCACAAGTCCTGGATGTTGTGTGTATCGAGAGGCCAAAGGCTGGTGGCAAGTGCACGGGGCACAGCGGAGTCTGTC CTGTGACGCGCAAGTCTGAGGGTCTGGGCGGCGGGCGGCTGGGTCTGTGCATTTCTGGTTGCACCGCGGCGCTTCCCAGCACCAACATGT >In-frame_ENST00000263579_ENST00000227507_TCGA-IG-A3I8_DCPS_chr11_126176639_+_CCND1_chr11_69462761_length(amino acids)=303AA_start in transcript=107_stop in transcript=1018 MRAGRHHNGAKGSNSVERRALGQVSGLRHARHASRRSGCQSRVGRELAAQPGRWTRARGGASAGGAGAHRLRGSMADAAPQLGKRKRELD VEEAHAASTEEKEAGVGNGTCAPVRLPFSGFRLQKVLRESARDKIIFLHGKVNEASGDGDGEDAVVILEKTPFQVEQVAQLLTGSPELQL QFSNDIYSTYHLFPPRQLNDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCDPDCLRACQEQIEALLESSLRQA -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for DCPS-CCND1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for DCPS-CCND1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | CCND1 | P24385 | DB01169 | Arsenic trioxide | Antagonist | Small molecule | Approved|Investigational |
Tgene | CCND1 | P24385 | DB01169 | Arsenic trioxide | Antagonist | Small molecule | Approved|Investigational |
Tgene | CCND1 | P24385 | DB01169 | Arsenic trioxide | Antagonist | Small molecule | Approved|Investigational |
Tgene | CCND1 | P24385 | DB11718 | Encorafenib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | CCND1 | P24385 | DB11718 | Encorafenib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | CCND1 | P24385 | DB11718 | Encorafenib | Inhibitor | Small molecule | Approved|Investigational |
Tgene | CCND1 | P24385 | DB00945 | Acetylsalicylic acid | Downregulator | Small molecule | Approved|Vet_approved |
Tgene | CCND1 | P24385 | DB00945 | Acetylsalicylic acid | Downregulator | Small molecule | Approved|Vet_approved |
Tgene | CCND1 | P24385 | DB00945 | Acetylsalicylic acid | Downregulator | Small molecule | Approved|Vet_approved |
Top |
Related Diseases for DCPS-CCND1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DCPS | C4085595 | AL-RAQAD SYNDROME | 2 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Tgene | CCND1 | C0006142 | Malignant neoplasm of breast | 6 | CTD_human |
Tgene | CCND1 | C0678222 | Breast Carcinoma | 6 | CTD_human |
Tgene | CCND1 | C1257931 | Mammary Neoplasms, Human | 6 | CTD_human |
Tgene | CCND1 | C1458155 | Mammary Neoplasms | 6 | CTD_human |
Tgene | CCND1 | C4704874 | Mammary Carcinoma, Human | 6 | CTD_human |
Tgene | CCND1 | C2239176 | Liver carcinoma | 5 | CTD_human |
Tgene | CCND1 | C0007097 | Carcinoma | 4 | CTD_human |
Tgene | CCND1 | C0007102 | Malignant tumor of colon | 4 | CTD_human |
Tgene | CCND1 | C0009375 | Colonic Neoplasms | 4 | CTD_human |
Tgene | CCND1 | C0024667 | Animal Mammary Neoplasms | 4 | CTD_human |
Tgene | CCND1 | C0205696 | Anaplastic carcinoma | 4 | CTD_human |
Tgene | CCND1 | C0205697 | Carcinoma, Spindle-Cell | 4 | CTD_human |
Tgene | CCND1 | C0205698 | Undifferentiated carcinoma | 4 | CTD_human |
Tgene | CCND1 | C0205699 | Carcinomatosis | 4 | CTD_human |
Tgene | CCND1 | C1257925 | Mammary Carcinoma, Animal | 4 | CTD_human |
Tgene | CCND1 | C0024668 | Mammary Neoplasms, Experimental | 3 | CTD_human |
Tgene | CCND1 | C0006118 | Brain Neoplasms | 2 | CTD_human |
Tgene | CCND1 | C0007621 | Neoplastic Cell Transformation | 2 | CTD_human |
Tgene | CCND1 | C0020507 | Hyperplasia | 2 | CTD_human |
Tgene | CCND1 | C0024121 | Lung Neoplasms | 2 | CTD_human |
Tgene | CCND1 | C0153633 | Malignant neoplasm of brain | 2 | CTD_human |
Tgene | CCND1 | C0242379 | Malignant neoplasm of lung | 2 | CTD_human |
Tgene | CCND1 | C0334634 | Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 2 | CTD_human |
Tgene | CCND1 | C0496899 | Benign neoplasm of brain, unspecified | 2 | CTD_human |
Tgene | CCND1 | C0750974 | Brain Tumor, Primary | 2 | CTD_human |
Tgene | CCND1 | C0750977 | Recurrent Brain Neoplasm | 2 | CTD_human |
Tgene | CCND1 | C0750979 | Primary malignant neoplasm of brain | 2 | CTD_human |
Tgene | CCND1 | C0751958 | Lymphoma, Lymphocytic, Intermediate | 2 | CTD_human |
Tgene | CCND1 | C1168401 | Squamous cell carcinoma of the head and neck | 2 | CTD_human |
Tgene | CCND1 | C1527390 | Neoplasms, Intracranial | 2 | CTD_human |
Tgene | CCND1 | C0001418 | Adenocarcinoma | 1 | CTD_human |
Tgene | CCND1 | C0006079 | Bowen's Disease | 1 | CTD_human |
Tgene | CCND1 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
Tgene | CCND1 | C0007138 | Carcinoma, Transitional Cell | 1 | CTD_human |
Tgene | CCND1 | C0007528 | Cecal Neoplasms | 1 | CTD_human |
Tgene | CCND1 | C0007873 | Uterine Cervical Neoplasm | 1 | CTD_human |
Tgene | CCND1 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
Tgene | CCND1 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
Tgene | CCND1 | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
Tgene | CCND1 | C0018923 | Hemangiosarcoma | 1 | CTD_human |
Tgene | CCND1 | C0019207 | Hepatoma, Morris | 1 | CTD_human |
Tgene | CCND1 | C0019208 | Hepatoma, Novikoff | 1 | CTD_human |
Tgene | CCND1 | C0020502 | Hyperparathyroidism | 1 | CTD_human |
Tgene | CCND1 | C0021846 | Intestinal Polyps | 1 | CTD_human |
Tgene | CCND1 | C0022665 | Kidney Neoplasm | 1 | CTD_human |
Tgene | CCND1 | C0023418 | leukemia | 1 | CTD_human |
Tgene | CCND1 | C0023903 | Liver neoplasms | 1 | CTD_human |
Tgene | CCND1 | C0023904 | Liver Neoplasms, Experimental | 1 | CTD_human |
Tgene | CCND1 | C0024623 | Malignant neoplasm of stomach | 1 | CTD_human |
Tgene | CCND1 | C0026764 | Multiple Myeloma | 1 | CTD_human;ORPHANET |
Tgene | CCND1 | C0027659 | Neoplasms, Experimental | 1 | CTD_human |
Tgene | CCND1 | C0030354 | Papilloma | 1 | CTD_human |
Tgene | CCND1 | C0032927 | Precancerous Conditions | 1 | CTD_human |
Tgene | CCND1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | CCND1 | C0036095 | Salivary Gland Neoplasms | 1 | CTD_human |
Tgene | CCND1 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | CCND1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Tgene | CCND1 | C0040136 | Thyroid Neoplasm | 1 | CTD_human |
Tgene | CCND1 | C0041696 | Unipolar Depression | 1 | PSYGENET |
Tgene | CCND1 | C0042076 | Urologic Neoplasms | 1 | CTD_human |
Tgene | CCND1 | C0086404 | Experimental Hepatoma | 1 | CTD_human |
Tgene | CCND1 | C0151468 | Thyroid Gland Follicular Adenoma | 1 | CTD_human |
Tgene | CCND1 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Tgene | CCND1 | C0153437 | Malignant neoplasm of cecum | 1 | CTD_human |
Tgene | CCND1 | C0205641 | Adenocarcinoma, Basal Cell | 1 | CTD_human |
Tgene | CCND1 | C0205642 | Adenocarcinoma, Oxyphilic | 1 | CTD_human |
Tgene | CCND1 | C0205643 | Carcinoma, Cribriform | 1 | CTD_human |
Tgene | CCND1 | C0205644 | Carcinoma, Granular Cell | 1 | CTD_human |
Tgene | CCND1 | C0205645 | Adenocarcinoma, Tubular | 1 | CTD_human |
Tgene | CCND1 | C0205874 | Papilloma, Squamous Cell | 1 | CTD_human |
Tgene | CCND1 | C0205875 | Papillomatosis | 1 | CTD_human |
Tgene | CCND1 | C0220636 | Malignant neoplasm of salivary gland | 1 | CTD_human |
Tgene | CCND1 | C0235874 | Disease Exacerbation | 1 | CTD_human |
Tgene | CCND1 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
Tgene | CCND1 | C0282313 | Condition, Preneoplastic | 1 | CTD_human |
Tgene | CCND1 | C0345904 | Malignant neoplasm of liver | 1 | CTD_human |
Tgene | CCND1 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
Tgene | CCND1 | C0476089 | Endometrial Carcinoma | 1 | CTD_human |
Tgene | CCND1 | C0546837 | Malignant neoplasm of esophagus | 1 | CTD_human |
Tgene | CCND1 | C0549473 | Thyroid carcinoma | 1 | CTD_human |
Tgene | CCND1 | C0740457 | Malignant neoplasm of kidney | 1 | CTD_human |
Tgene | CCND1 | C0751571 | Cancer of Urinary Tract | 1 | CTD_human |
Tgene | CCND1 | C0919532 | Genomic Instability | 1 | CTD_human |
Tgene | CCND1 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
Tgene | CCND1 | C1708349 | Hereditary Diffuse Gastric Cancer | 1 | CTD_human |
Tgene | CCND1 | C2931822 | Nasopharyngeal carcinoma | 1 | CTD_human |
Tgene | CCND1 | C4048328 | cervical cancer | 1 | CTD_human |