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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:DDX39B-ETV7 (FusionGDB2 ID:21968) |
Fusion Gene Summary for DDX39B-ETV7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DDX39B-ETV7 | Fusion gene ID: 21968 | Hgene | Tgene | Gene symbol | DDX39B | ETV7 | Gene ID | 7919 | 51513 |
| Gene name | DExD-box helicase 39B | ETS variant transcription factor 7 | |
| Synonyms | BAT1|D6S81E|UAP56 | TEL-2|TEL2|TELB | |
| Cytomap | 6p21.33 | 6p21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | spliceosome RNA helicase DDX39B56 kDa U2AF65-associated proteinATP-dependent RNA helicase p47DEAD (Asp-Glu-Ala-Asp) box polypeptide 39BDEAD-box helicase 39BHLA-B-associated transcript 1 proteinnuclear RNA helicase (DEAD family)spliceosome RNA helic | transcription factor ETV7ETS translocation variant 7ETS variant 7ETS-related protein Tel2Ets transcription factor TEL-2bTEL2 oncogeneets variant gene 7 (TEL2 oncogene)tel-related Ets factor | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q13838 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000376177, ENST00000396172, ENST00000417556, ENST00000458640, ENST00000462421, ENST00000415382, ENST00000453105, ENST00000449074, ENST00000552820, ENST00000463430, ENST00000438578, ENST00000415689, ENST00000456476, ENST00000412106, ENST00000547039, ENST00000550435, ENST00000453488, ENST00000453138, ENST00000552288, ENST00000441425, ENST00000456666, ENST00000546633, ENST00000483957, ENST00000430703, ENST00000416863, ENST00000413678, ENST00000414440, ENST00000547489, ENST00000551031, ENST00000468089, ENST00000400293, ENST00000400296, ENST00000400295, ENST00000383508, ENST00000548340, ENST00000548331, ENST00000495391, ENST00000446341, ENST00000548614, ENST00000448296, ENST00000412330, ENST00000445218, ENST00000546637, ENST00000489325, ENST00000450987, ENST00000431360, ENST00000430784, ENST00000550217, ENST00000470514, ENST00000549374, | ENST00000339796, ENST00000373737, ENST00000340181, ENST00000373738, ENST00000538992, | |
| Fusion gene scores | * DoF score | 8 X 6 X 6=288 | 4 X 4 X 4=64 |
| # samples | 9 | 5 | |
| ** MAII score | log2(9/288*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DDX39B [Title/Abstract] AND ETV7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | DDX39B(31503144)-ETV7(36353446), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | DDX39B-ETV7 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. DDX39B-ETV7 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF. DDX39B-ETV7 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DDX39B | GO:0000245 | spliceosomal complex assembly | 18593880 |
| Hgene | DDX39B | GO:0006406 | mRNA export from nucleus | 17190602 |
| Hgene | DDX39B | GO:0008380 | RNA splicing | 18593880 |
| Hgene | DDX39B | GO:0010501 | RNA secondary structure unwinding | 18593880 |
| Hgene | DDX39B | GO:0046784 | viral mRNA export from host cell nucleus | 18974867 |
| Tgene | ETV7 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 11108721 |
| Fusion gene breakpoints across DDX39B (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across ETV7 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | PAAD | TCGA-XN-A8T5-01A | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| ChimerDB4 | PAAD | TCGA-XN-A8T5 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| ChimerDB4 | PAAD | TCGA-XN-A8T5-01A | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
Top |
Fusion Gene ORF analysis for DDX39B-ETV7 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000376177 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| Frame-shift | ENST00000376177 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| Frame-shift | ENST00000376177 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| Frame-shift | ENST00000376177 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| 5CDS-intron | ENST00000376177 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| Frame-shift | ENST00000396172 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| Frame-shift | ENST00000396172 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| Frame-shift | ENST00000396172 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| Frame-shift | ENST00000396172 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| 5CDS-intron | ENST00000396172 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| Frame-shift | ENST00000417556 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| Frame-shift | ENST00000417556 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| Frame-shift | ENST00000417556 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| Frame-shift | ENST00000417556 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| 5CDS-intron | ENST00000417556 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| Frame-shift | ENST00000458640 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| Frame-shift | ENST00000458640 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| Frame-shift | ENST00000458640 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| Frame-shift | ENST00000458640 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| 5CDS-intron | ENST00000458640 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000462421 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000462421 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000462421 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000462421 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000462421 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| Frame-shift | ENST00000415382 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| Frame-shift | ENST00000415382 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| Frame-shift | ENST00000415382 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| Frame-shift | ENST00000415382 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| 5CDS-intron | ENST00000415382 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000453105 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000453105 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000453105 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000453105 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000453105 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000449074 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000449074 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000449074 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000449074 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000449074 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000552820 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000552820 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000552820 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000552820 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000552820 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000463430 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000463430 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000463430 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000463430 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000463430 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000438578 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000438578 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000438578 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000438578 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000438578 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000415689 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000415689 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000415689 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000415689 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000415689 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000456476 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000456476 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000456476 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000456476 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000456476 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000412106 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000412106 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000412106 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000412106 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000412106 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000547039 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000547039 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000547039 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000547039 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000547039 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000550435 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000550435 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000550435 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000550435 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000550435 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000453488 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000453488 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000453488 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000453488 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000453488 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000453138 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000453138 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000453138 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000453138 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000453138 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000552288 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000552288 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000552288 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000552288 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000552288 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000441425 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000441425 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000441425 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000441425 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000441425 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000456666 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000456666 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000456666 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000456666 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000456666 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000546633 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000546633 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000546633 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000546633 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000546633 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000483957 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000483957 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000483957 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000483957 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000483957 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000430703 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000430703 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000430703 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000430703 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000430703 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000416863 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000416863 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000416863 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000416863 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000416863 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000413678 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000413678 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000413678 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000413678 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000413678 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000414440 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000414440 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000414440 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000414440 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000414440 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000547489 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000547489 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000547489 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000547489 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000547489 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000551031 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000551031 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000551031 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000551031 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000551031 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000468089 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000468089 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000468089 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000468089 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000468089 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000400293 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000400293 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000400293 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000400293 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000400293 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000400296 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000400296 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000400296 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000400296 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000400296 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000400295 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000400295 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000400295 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000400295 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000400295 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000383508 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000383508 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000383508 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000383508 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000383508 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000548340 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000548340 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000548340 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000548340 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000548340 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000548331 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000548331 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000548331 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000548331 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000548331 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000495391 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000495391 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000495391 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000495391 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000495391 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000446341 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000446341 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000446341 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000446341 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000446341 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000548614 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000548614 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000548614 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000548614 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000548614 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000448296 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000448296 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000448296 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000448296 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000448296 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000412330 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000412330 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000412330 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000412330 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000412330 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000445218 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000445218 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000445218 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000445218 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000445218 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000546637 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000546637 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000546637 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000546637 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000546637 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000489325 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000489325 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000489325 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000489325 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000489325 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000450987 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000450987 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000450987 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000450987 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000450987 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000431360 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000431360 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000431360 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000431360 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000431360 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000430784 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000430784 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000430784 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000430784 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000430784 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000550217 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000550217 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000550217 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000550217 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000550217 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000470514 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000470514 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000470514 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000470514 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000470514 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000549374 | ENST00000339796 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000549374 | ENST00000373737 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000549374 | ENST00000340181 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-3CDS | ENST00000549374 | ENST00000373738 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| intron-intron | ENST00000549374 | ENST00000538992 | DDX39B | chr6 | 31503144 | - | ETV7 | chr6 | 36353446 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for DDX39B-ETV7 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for DDX39B-ETV7 |
| Go to FGviewer for the breakpoints of :-: - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DDX39B | . |
| FUNCTION: Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC and CHTOP onto mRNA. Also associates with pre-mRNA independent of ALYREF/THOC4 and the THO complex. Involved in the nuclear export of intronless mRNA; the ATP-bound form is proposed to recruit export adapter ALYREF/THOC4 to intronless mRNA; its ATPase activity is cooperatively stimulated by RNA and ALYREF/THOC4 and ATP hydrolysis is thought to trigger the dissociation from RNA to allow the association of ALYREF/THOC4 and the NXF1-NXT1 heterodimer. Involved in transcription elongation and genome stability. {ECO:0000269|PubMed:11675789, ECO:0000269|PubMed:15585580, ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:17562711, ECO:0000269|PubMed:17984224, ECO:0000269|PubMed:20844015, ECO:0000269|PubMed:22144908, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:23299939, ECO:0000269|PubMed:9242493}.; FUNCTION: Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly with [PubMed:23299939] reporting a stimulatory effect. {ECO:0000269|PubMed:23299939, ECO:0000269|PubMed:9242493}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for DDX39B-ETV7 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for DDX39B-ETV7 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for DDX39B-ETV7 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for DDX39B-ETV7 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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