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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:DDX5-ADAM18 (FusionGDB2 ID:22019) |
Fusion Gene Summary for DDX5-ADAM18 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DDX5-ADAM18 | Fusion gene ID: 22019 | Hgene | Tgene | Gene symbol | DDX5 | ADAM18 | Gene ID | 1655 | 8749 |
| Gene name | DEAD-box helicase 5 | ADAM metallopeptidase domain 18 | |
| Synonyms | G17P1|HLR1|HUMP68|p68 | ADAM27|tMDCIII | |
| Cytomap | 17q23.3 | 8p11.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | probable ATP-dependent RNA helicase DDX5ATP-dependent RNA helicase DDX5DEAD (Asp-Glu-Ala-Asp) box helicase 5DEAD (Asp-Glu-Ala-Asp) box polypeptide 5DEAD box protein 5DEAD box-5DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 5 (RNA helicase, 68kD)RNA h | disintegrin and metalloproteinase domain-containing protein 18a disintegrin and metalloproteinase domain 18transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | P17844 | Q9Y3Q7 | |
| Ensembl transtripts involved in fusion gene | ENST00000225792, ENST00000450599, ENST00000578804, ENST00000580026, | ENST00000265707, ENST00000379866, ENST00000520772, ENST00000541111, ENST00000523755, | |
| Fusion gene scores | * DoF score | 33 X 25 X 10=8250 | 8 X 8 X 6=384 |
| # samples | 27 | 9 | |
| ** MAII score | log2(27/8250*10)=-4.93336280696971 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/384*10)=-2.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DDX5 [Title/Abstract] AND ADAM18 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | DDX5(62498128)-ADAM18(39495984), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | DDX5-ADAM18 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. DDX5-ADAM18 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. DDX5-ADAM18 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DDX5 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 15298701 |
| Hgene | DDX5 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome | 21343338 |
| Hgene | DDX5 | GO:0000956 | nuclear-transcribed mRNA catabolic process | 23788676 |
| Fusion gene breakpoints across DDX5 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across ADAM18 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-AR-A250-01A | DDX5 | chr17 | 62498128 | - | ADAM18 | chr8 | 39495984 | + |
| ChimerDB4 | BRCA | TCGA-AR-A250-01A | DDX5 | chr17 | 62498128 | - | ADAM18 | chr8 | 39495984 | + |
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Fusion Gene ORF analysis for DDX5-ADAM18 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000225792 | ENST00000265707 | DDX5 | chr17 | 62498128 | - | ADAM18 | chr8 | 39495984 | + |
| Frame-shift | ENST00000225792 | ENST00000379866 | DDX5 | chr17 | 62498128 | - | ADAM18 | chr8 | 39495984 | + |
| 5CDS-intron | ENST00000225792 | ENST00000520772 | DDX5 | chr17 | 62498128 | - | ADAM18 | chr8 | 39495984 | + |
| 5CDS-5UTR | ENST00000225792 | ENST00000541111 | DDX5 | chr17 | 62498128 | - | ADAM18 | chr8 | 39495984 | + |
| 5CDS-intron | ENST00000225792 | ENST00000523755 | DDX5 | chr17 | 62498128 | - | ADAM18 | chr8 | 39495984 | + |
| Frame-shift | ENST00000450599 | ENST00000265707 | DDX5 | chr17 | 62498128 | - | ADAM18 | chr8 | 39495984 | + |
| Frame-shift | ENST00000450599 | ENST00000379866 | DDX5 | chr17 | 62498128 | - | ADAM18 | chr8 | 39495984 | + |
| 5CDS-intron | ENST00000450599 | ENST00000520772 | DDX5 | chr17 | 62498128 | - | ADAM18 | chr8 | 39495984 | + |
| 5CDS-5UTR | ENST00000450599 | ENST00000541111 | DDX5 | chr17 | 62498128 | - | ADAM18 | chr8 | 39495984 | + |
| 5CDS-intron | ENST00000450599 | ENST00000523755 | DDX5 | chr17 | 62498128 | - | ADAM18 | chr8 | 39495984 | + |
| Frame-shift | ENST00000578804 | ENST00000265707 | DDX5 | chr17 | 62498128 | - | ADAM18 | chr8 | 39495984 | + |
| Frame-shift | ENST00000578804 | ENST00000379866 | DDX5 | chr17 | 62498128 | - | ADAM18 | chr8 | 39495984 | + |
| 5CDS-intron | ENST00000578804 | ENST00000520772 | DDX5 | chr17 | 62498128 | - | ADAM18 | chr8 | 39495984 | + |
| 5CDS-5UTR | ENST00000578804 | ENST00000541111 | DDX5 | chr17 | 62498128 | - | ADAM18 | chr8 | 39495984 | + |
| 5CDS-intron | ENST00000578804 | ENST00000523755 | DDX5 | chr17 | 62498128 | - | ADAM18 | chr8 | 39495984 | + |
| intron-3CDS | ENST00000580026 | ENST00000265707 | DDX5 | chr17 | 62498128 | - | ADAM18 | chr8 | 39495984 | + |
| intron-3CDS | ENST00000580026 | ENST00000379866 | DDX5 | chr17 | 62498128 | - | ADAM18 | chr8 | 39495984 | + |
| intron-intron | ENST00000580026 | ENST00000520772 | DDX5 | chr17 | 62498128 | - | ADAM18 | chr8 | 39495984 | + |
| intron-5UTR | ENST00000580026 | ENST00000541111 | DDX5 | chr17 | 62498128 | - | ADAM18 | chr8 | 39495984 | + |
| intron-intron | ENST00000580026 | ENST00000523755 | DDX5 | chr17 | 62498128 | - | ADAM18 | chr8 | 39495984 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for DDX5-ADAM18 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| DDX5 | chr17 | 62498127 | - | ADAM18 | chr8 | 39495983 | + | 0.013981081 | 0.9860189 |
| DDX5 | chr17 | 62498127 | - | ADAM18 | chr8 | 39495983 | + | 0.013981081 | 0.9860189 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for DDX5-ADAM18 |
| Go to FGviewer for the breakpoints of :-: - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DDX5 | ADAM18 |
| FUNCTION: Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. {ECO:0000269|PubMed:12527917, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:15660129, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17960593, ECO:0000269|PubMed:18829551, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:21343338}. | FUNCTION: Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for DDX5-ADAM18 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for DDX5-ADAM18 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for DDX5-ADAM18 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for DDX5-ADAM18 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DDX5 | C0014175 | Endometriosis | 1 | CTD_human |
| Hgene | DDX5 | C0269102 | Endometrioma | 1 | CTD_human |
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