Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DEGS2-RFWD2 (FusionGDB2 ID:22159)

Fusion Gene Summary for DEGS2-RFWD2

Fusion gene summary

Fusion gene information	Fusion gene name: DEGS2-RFWD2
	Fusion gene ID: 22159
		Hgene	Tgene
	Gene symbol	DEGS2	RFWD2
	Gene ID	123099	64326
	Gene name	delta 4-desaturase, sphingolipid 2	COP1 E3 ubiquitin ligase
	Synonyms	C14orf66\|DES2\|FADS8	CFAP78\|FAP78\|RFWD2\|RNF200
	Cytomap	14q32.2	1q25.1-q25.2
	Type of gene	protein-coding	protein-coding
	Description	sphingolipid delta(4)-desaturase/C4-monooxygenase DES2degenerative spermatocyte homolog 2, lipid desaturasedihydroceramide desaturase 2sphingolipid 4-desaturasesphingolipid C4-hydroxylase/delta 4-desaturasesphingolipid C4-monooxygenasesphingolipid d	E3 ubiquitin-protein ligase COP1E3 ubiquitin-protein ligase RFWD2RING finger protein 200RING-type E3 ubiquitin transferase RFWD2constitutive photomorphogenesis protein 1 homologconstitutive photomorphogenic protein 1putative ubiquitin ligase COP1ri
	Modification date	20200313	20200313
	UniProtAcc	Q6QHC5	.
	Ensembl transtripts involved in fusion gene	ENST00000305631, ENST00000553834, ENST00000557117,	ENST00000367669, ENST00000308769,
Fusion gene scores	* DoF score	2 X 2 X 2=8	28 X 17 X 12=5712
	# samples	3	27
	** MAII score	log2(3/8*10)=1.90689059560852	log2(27/5712*10)=-4.40296466697827 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: DEGS2 [Title/Abstract] AND RFWD2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DEGS2(100625842)-RFWD2(176055026), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	RFWD2	GO:0010212	response to ionizing radiation	19805145

Fusion gene breakpoints across DEGS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RFWD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	61N	DEGS2	chr14	100625842	-	RFWD2	chr1	176055026	-

Top

Fusion Gene ORF analysis for DEGS2-RFWD2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000305631	ENST00000367669	DEGS2	chr14	100625842	-	RFWD2	chr1	176055026	-
In-frame	ENST00000305631	ENST00000308769	DEGS2	chr14	100625842	-	RFWD2	chr1	176055026	-
In-frame	ENST00000553834	ENST00000367669	DEGS2	chr14	100625842	-	RFWD2	chr1	176055026	-
In-frame	ENST00000553834	ENST00000308769	DEGS2	chr14	100625842	-	RFWD2	chr1	176055026	-
intron-3CDS	ENST00000557117	ENST00000367669	DEGS2	chr14	100625842	-	RFWD2	chr1	176055026	-
intron-3CDS	ENST00000557117	ENST00000308769	DEGS2	chr14	100625842	-	RFWD2	chr1	176055026	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000305631	DEGS2	chr14	100625842	-	ENST00000367669	RFWD2	chr1	176055026	-	2150	658	496	1827	443
ENST00000305631	DEGS2	chr14	100625842	-	ENST00000308769	RFWD2	chr1	176055026	-	1828	658	496	1827	444
ENST00000553834	DEGS2	chr14	100625842	-	ENST00000367669	RFWD2	chr1	176055026	-	1582	90	162	1259	365
ENST00000553834	DEGS2	chr14	100625842	-	ENST00000308769	RFWD2	chr1	176055026	-	1260	90	162	1259	365

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000305631	ENST00000367669	DEGS2	chr14	100625842	-	RFWD2	chr1	176055026	-	0.000587125	0.9994129
ENST00000305631	ENST00000308769	DEGS2	chr14	100625842	-	RFWD2	chr1	176055026	-	0.001215815	0.99878424
ENST00000553834	ENST00000367669	DEGS2	chr14	100625842	-	RFWD2	chr1	176055026	-	0.000212889	0.99978715
ENST00000553834	ENST00000308769	DEGS2	chr14	100625842	-	RFWD2	chr1	176055026	-	0.000337002	0.999663

Top

Fusion Genomic Features for DEGS2-RFWD2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for DEGS2-RFWD2

Go to
FGviewer for the breakpoints of chr14:100625842-chr1:176055026
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DEGS2 Q6QHC5	.
FUNCTION: Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase. {ECO:0000269\|PubMed:15063729}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RFWD2

chr14:100625842

chr1:176055026

ENST00000308769

419_458

318.0

708.0

Repeat

Note=WD 1

Tgene

RFWD2

chr14:100625842

chr1:176055026

ENST00000308769

468_508

318.0

708.0

Repeat

Note=WD 2

Tgene

RFWD2

chr14:100625842

chr1:176055026

ENST00000308769

511_551

318.0

708.0

Repeat

Note=WD 3

Tgene

RFWD2

chr14:100625842

chr1:176055026

ENST00000308769

553_593

318.0

708.0

Repeat

Note=WD 4

Tgene

RFWD2

chr14:100625842

chr1:176055026

ENST00000308769

597_635

318.0

708.0

Repeat

Note=WD 5

Tgene

RFWD2

chr14:100625842

chr1:176055026

ENST00000308769

638_677

318.0

708.0

Repeat

Note=WD 6

Tgene

RFWD2

chr14:100625842

chr1:176055026

ENST00000308769

691_729

318.0

708.0

Repeat

Note=WD 7

Tgene

RFWD2

chr14:100625842

chr1:176055026

ENST00000367669

419_458

342.0

732.0

Repeat

Note=WD 1

Tgene

RFWD2

chr14:100625842

chr1:176055026

ENST00000367669

468_508

342.0

732.0

Repeat

Note=WD 2

Tgene

RFWD2

chr14:100625842

chr1:176055026

ENST00000367669

511_551

342.0

732.0

Repeat

Note=WD 3

Tgene

RFWD2

chr14:100625842

chr1:176055026

ENST00000367669

553_593

342.0

732.0

Repeat

Note=WD 4

Tgene

RFWD2

chr14:100625842

chr1:176055026

ENST00000367669

597_635

342.0

732.0

Repeat

Note=WD 5

Tgene

RFWD2

chr14:100625842

chr1:176055026

ENST00000367669

638_677

342.0

732.0

Repeat

Note=WD 6

Tgene

RFWD2

chr14:100625842

chr1:176055026

ENST00000367669

691_729

342.0

732.0

Repeat

Note=WD 7

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DEGS2

chr14:100625842

chr1:176055026

ENST00000305631

128_132

27.333333333333332

324.0

Motif

Histidine box-2

Hgene

DEGS2

chr14:100625842

chr1:176055026

ENST00000305631

259_263

27.333333333333332

324.0

Motif

Histidine box-3

Hgene

DEGS2

chr14:100625842

chr1:176055026

ENST00000305631

89_93

27.333333333333332

324.0

Motif

Histidine box-1

Hgene

DEGS2

chr14:100625842

chr1:176055026

ENST00000305631

95_99

27.333333333333332

324.0

Region

Required for C4-hydroxylase activity

Hgene

DEGS2

chr14:100625842

chr1:176055026

ENST00000305631

210_231

27.333333333333332

324.0

Transmembrane

Helical

Hgene

DEGS2

chr14:100625842

chr1:176055026

ENST00000305631

45_65

27.333333333333332

324.0

Transmembrane

Helical

Hgene

DEGS2

chr14:100625842

chr1:176055026

ENST00000305631

68_88

27.333333333333332

324.0

Transmembrane

Helical

Tgene

RFWD2

chr14:100625842

chr1:176055026

ENST00000308769

233_301

318.0

708.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

RFWD2

chr14:100625842

chr1:176055026

ENST00000367669

233_301

342.0

732.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

RFWD2

chr14:100625842

chr1:176055026

ENST00000308769

2_110

318.0

708.0

Compositional bias

Note=Ser-rich

Tgene

RFWD2

chr14:100625842

chr1:176055026

ENST00000367669

2_110

342.0

732.0

Compositional bias

Note=Ser-rich

Tgene

RFWD2

chr14:100625842

chr1:176055026

ENST00000308769

109_113

318.0

708.0

Motif

Note=Nuclear localization signal 1

Tgene

RFWD2

chr14:100625842

chr1:176055026

ENST00000308769

195_206

318.0

708.0

Motif

Note=Nuclear localization signal 2

Tgene

RFWD2

chr14:100625842

chr1:176055026

ENST00000308769

235_245

318.0

708.0

Motif

Nuclear export signal

Tgene

RFWD2

chr14:100625842

chr1:176055026

ENST00000367669

109_113

342.0

732.0

Motif

Note=Nuclear localization signal 1

Tgene

RFWD2

chr14:100625842

chr1:176055026

ENST00000367669

195_206

342.0

732.0

Motif

Note=Nuclear localization signal 2

Tgene

RFWD2

chr14:100625842

chr1:176055026

ENST00000367669

235_245

342.0

732.0

Motif

Nuclear export signal

Tgene

RFWD2

chr14:100625842

chr1:176055026

ENST00000308769

136_174

318.0

708.0

Zinc finger

RING-type

Tgene

RFWD2

chr14:100625842

chr1:176055026

ENST00000367669

136_174

342.0

732.0

Zinc finger

RING-type

Top

Fusion Gene Sequence for DEGS2-RFWD2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000305631_ENST00000367669_61N_DEGS2_chr14_100625842_-_RFWD2_chr1_176055026_length(transcript)=2150nt_BP=658nt
CGGGTGGAGGAAGGGAGGATTGCTGCACCAACCTTTCCTCGGCGCCTGTTTACTGGCACCGTCGCATCCATTCCACGCCGATCCTCCGCA
GTCCCCCTATCCTGCCAGCCGCTCCTCCTTGGGGCAGGGGCGGCGCGAGCCACAGGGGCGTGCCCGCGAGCGGGTCGGGGCTGCGGAGAG
AACGGGCCGGGGTAAAAACCCGACGGCTGCCCGCGGGTGGGCGGGGCGCGCAGAGCCGGTGGGAGGCCGCGGTGGCAGCAGTCGCCCCCG
CGCATCGAGGGACCCAGGGACTCGCGCAGATGGCACGCGGCCACCTCGGTCCTGCCGGGGAGCCCCATTTCCAACCGAGGCAACTGAGGT
TCCCAAAGCGCCAGCTACCCGCCGGGGTCTGGAGAGCGCCGGGGCCCGGCCGCCCCGCCCAGCCAGAGGTGCCCCGCCCCAAGCCTGGCG
CACCTGGCCCCGCCCCGCCGGGACCCCGCCCCCGCCCTAATCAGAGCTGGTTCCGCGCCGCGGCCGCCGCGACAGGTGCAGCAGAGCCGA
GCCGGCCGCGCTCCGAACGGCGCCTCCCGCCCCACCATGGGCAACAGCGCGAGCCGCAGCGACTTCGAGTGGGTCTACACCGACCAGCCG
CACACGCAGCGGCGCAAGGAGATACTGGACAAAGAAACAGCCTTGGTATAATAGCACGTTAGCATCAAGACGAAAACGACTTACTGCTCA
TTTTGAAGACTTGGAGCAGTGTTACTTTTCTACAAGGATGTCTCGTATCTCAGATGACAGTCGAACTGCAAGCCAGTTGGATGAATTTCA
GGAATGCTTGTCCAAGTTTACTCGATATAATTCAGTACGACCTTTAGCCACATTGTCATATGCTAGTGATCTCTATAATGGTTCCAGTAT
AGTCTCTAGTATTGAATTTGACCGGGATTGTGACTATTTTGCGATTGCTGGAGTTACAAAGAAGATTAAAGTCTATGAATATGACACTGT
CATCCAGGATGCAGTGGATATTCATTACCCTGAGAATGAAATGACCTGCAATTCGAAAATCAGCTGTATCAGTTGGAGTAGTTACCATAA
GAACCTGTTAGCTAGCAGTGATTATGAAGGCACTGTTATTTTATGGGATGGATTCACAGGACAGAGGTCAAAGGTCTATCAGGAGCATGA
GAAGAGGTGTTGGAGTGTTGACTTTAATTTGATGGATCCTAAACTCTTGGCTTCAGGTTCTGATGATGCAAAAGTGAAGCTGTGGTCTAC
CAATCTAGACAACTCAGTGGCAAGCATTGAGGCAAAGGCTAATGTGTGCTGTGTTAAATTCAGCCCCTCTTCCAGATACCATTTGGCTTT
CGGCTGTGCAGATCACTGTGTCCACTACTATGATCTTCGTAACACTAAACAGCCAATCATGGTATTCAAAGGACACCGTAAAGCAGTCTC
TTATGCAAAGTTTGTGAGTGGTGAGGAAATTGTCTCTGCCTCAACAGACAGTCAGCTAAAACTGTGGAATGTAGGGAAACCATACTGCCT
ACGTTCCTTCAAGGGTCATATCAATGAAAAAAACTTTGTAGGCCTGGCTTCCAATGGAGATTATATAGCTTGTGGAAGTGAAAATAACTC
TCTCTACCTGTACTATAAAGGACTTTCTAAGACTTTGCTAACTTTTAAGTTTGATACAGTCAAAAGTGTTCTCGACAAAGACCGAAAAGA
AGATGATACAAATGAATTTGTTAGTGCTGTGTGCTGGAGGGCACTACCAGATGGGGAGTCCAATGTGCTGATTGCTGCTAACAGTCAGGG
TACAATTAAGGTGCTAGAATTGGTATGAAGGGTTAACTCAAGTCAAATTGTACTTGATCCTGCTGAAATACATCTGCAGCTGACAATGAG
AGAAGAAACAGAAAATGTCATGTGATGTCTCTCCCCAAAGTCATCATGGGTTTTGGATTTGTTTTGAATATTTTTTTCTTTTTTTCTTTT
CCCTCCTTTATGACCTTTGGGACATTGGGAATACCCAGCCAACTCTCCACCATCAATGTAACTCCATGGACATTGCTGCTCTTGGTGGTG

>In-frame_ENST00000305631_ENST00000367669_61N_DEGS2_chr14_100625842_-_RFWD2_chr1_176055026_length(amino acids)=443AA_start in transcript=496_stop in transcript=1827
MVPRRGRRDRCSRAEPAALRTAPPAPPWATARAAATSSGSTPTSRTRSGARRYWTKKQPWYNSTLASRRKRLTAHFEDLEQCYFSTRMSR
ISDDSRTASQLDEFQECLSKFTRYNSVRPLATLSYASDLYNGSSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDTVIQDAVDIHYPENEMT
CNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLDNSVASIEAKANV
CCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGL

--------------------------------------------------------------
>In-frame_ENST00000305631_ENST00000308769_61N_DEGS2_chr14_100625842_-_RFWD2_chr1_176055026_length(transcript)=1828nt_BP=658nt
CGGGTGGAGGAAGGGAGGATTGCTGCACCAACCTTTCCTCGGCGCCTGTTTACTGGCACCGTCGCATCCATTCCACGCCGATCCTCCGCA
GTCCCCCTATCCTGCCAGCCGCTCCTCCTTGGGGCAGGGGCGGCGCGAGCCACAGGGGCGTGCCCGCGAGCGGGTCGGGGCTGCGGAGAG
AACGGGCCGGGGTAAAAACCCGACGGCTGCCCGCGGGTGGGCGGGGCGCGCAGAGCCGGTGGGAGGCCGCGGTGGCAGCAGTCGCCCCCG
CGCATCGAGGGACCCAGGGACTCGCGCAGATGGCACGCGGCCACCTCGGTCCTGCCGGGGAGCCCCATTTCCAACCGAGGCAACTGAGGT
TCCCAAAGCGCCAGCTACCCGCCGGGGTCTGGAGAGCGCCGGGGCCCGGCCGCCCCGCCCAGCCAGAGGTGCCCCGCCCCAAGCCTGGCG
CACCTGGCCCCGCCCCGCCGGGACCCCGCCCCCGCCCTAATCAGAGCTGGTTCCGCGCCGCGGCCGCCGCGACAGGTGCAGCAGAGCCGA
GCCGGCCGCGCTCCGAACGGCGCCTCCCGCCCCACCATGGGCAACAGCGCGAGCCGCAGCGACTTCGAGTGGGTCTACACCGACCAGCCG
CACACGCAGCGGCGCAAGGAGATACTGGACAAAGAAACAGCCTTGGTATAATAGCACGTTAGCATCAAGACGAAAACGACTTACTGCTCA
TTTTGAAGACTTGGAGCAGTGTTACTTTTCTACAAGGATGTCTCGTATCTCAGATGACAGTCGAACTGCAAGCCAGTTGGATGAATTTCA
GGAATGCTTGTCCAAGTTTACTCGATATAATTCAGTACGACCTTTAGCCACATTGTCATATGCTAGTGATCTCTATAATGGTTCCAGTAT
AGTCTCTAGTATTGAATTTGACCGGGATTGTGACTATTTTGCGATTGCTGGAGTTACAAAGAAGATTAAAGTCTATGAATATGACACTGT
CATCCAGGATGCAGTGGATATTCATTACCCTGAGAATGAAATGACCTGCAATTCGAAAATCAGCTGTATCAGTTGGAGTAGTTACCATAA
GAACCTGTTAGCTAGCAGTGATTATGAAGGCACTGTTATTTTATGGGATGGATTCACAGGACAGAGGTCAAAGGTCTATCAGGAGCATGA
GAAGAGGTGTTGGAGTGTTGACTTTAATTTGATGGATCCTAAACTCTTGGCTTCAGGTTCTGATGATGCAAAAGTGAAGCTGTGGTCTAC
CAATCTAGACAACTCAGTGGCAAGCATTGAGGCAAAGGCTAATGTGTGCTGTGTTAAATTCAGCCCCTCTTCCAGATACCATTTGGCTTT
CGGCTGTGCAGATCACTGTGTCCACTACTATGATCTTCGTAACACTAAACAGCCAATCATGGTATTCAAAGGACACCGTAAAGCAGTCTC
TTATGCAAAGTTTGTGAGTGGTGAGGAAATTGTCTCTGCCTCAACAGACAGTCAGCTAAAACTGTGGAATGTAGGGAAACCATACTGCCT
ACGTTCCTTCAAGGGTCATATCAATGAAAAAAACTTTGTAGGCCTGGCTTCCAATGGAGATTATATAGCTTGTGGAAGTGAAAATAACTC
TCTCTACCTGTACTATAAAGGACTTTCTAAGACTTTGCTAACTTTTAAGTTTGATACAGTCAAAAGTGTTCTCGACAAAGACCGAAAAGA
AGATGATACAAATGAATTTGTTAGTGCTGTGTGCTGGAGGGCACTACCAGATGGGGAGTCCAATGTGCTGATTGCTGCTAACAGTCAGGG

>In-frame_ENST00000305631_ENST00000308769_61N_DEGS2_chr14_100625842_-_RFWD2_chr1_176055026_length(amino acids)=444AA_start in transcript=496_stop in transcript=1827
MVPRRGRRDRCSRAEPAALRTAPPAPPWATARAAATSSGSTPTSRTRSGARRYWTKKQPWYNSTLASRRKRLTAHFEDLEQCYFSTRMSR
ISDDSRTASQLDEFQECLSKFTRYNSVRPLATLSYASDLYNGSSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDTVIQDAVDIHYPENEMT
CNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLDNSVASIEAKANV
CCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGL

--------------------------------------------------------------
>In-frame_ENST00000553834_ENST00000367669_61N_DEGS2_chr14_100625842_-_RFWD2_chr1_176055026_length(transcript)=1582nt_BP=90nt
GCCCCACCATGGGCAACAGCGCGAGCCGCAGCGACTTCGAGTGGGTCTACACCGACCAGCCGCACACGCAGCGGCGCAAGGAGATACTGG
ACAAAGAAACAGCCTTGGTATAATAGCACGTTAGCATCAAGACGAAAACGACTTACTGCTCATTTTGAAGACTTGGAGCAGTGTTACTTT
TCTACAAGGATGTCTCGTATCTCAGATGACAGTCGAACTGCAAGCCAGTTGGATGAATTTCAGGAATGCTTGTCCAAGTTTACTCGATAT
AATTCAGTACGACCTTTAGCCACATTGTCATATGCTAGTGATCTCTATAATGGTTCCAGTATAGTCTCTAGTATTGAATTTGACCGGGAT
TGTGACTATTTTGCGATTGCTGGAGTTACAAAGAAGATTAAAGTCTATGAATATGACACTGTCATCCAGGATGCAGTGGATATTCATTAC
CCTGAGAATGAAATGACCTGCAATTCGAAAATCAGCTGTATCAGTTGGAGTAGTTACCATAAGAACCTGTTAGCTAGCAGTGATTATGAA
GGCACTGTTATTTTATGGGATGGATTCACAGGACAGAGGTCAAAGGTCTATCAGGAGCATGAGAAGAGGTGTTGGAGTGTTGACTTTAAT
TTGATGGATCCTAAACTCTTGGCTTCAGGTTCTGATGATGCAAAAGTGAAGCTGTGGTCTACCAATCTAGACAACTCAGTGGCAAGCATT
GAGGCAAAGGCTAATGTGTGCTGTGTTAAATTCAGCCCCTCTTCCAGATACCATTTGGCTTTCGGCTGTGCAGATCACTGTGTCCACTAC
TATGATCTTCGTAACACTAAACAGCCAATCATGGTATTCAAAGGACACCGTAAAGCAGTCTCTTATGCAAAGTTTGTGAGTGGTGAGGAA
ATTGTCTCTGCCTCAACAGACAGTCAGCTAAAACTGTGGAATGTAGGGAAACCATACTGCCTACGTTCCTTCAAGGGTCATATCAATGAA
AAAAACTTTGTAGGCCTGGCTTCCAATGGAGATTATATAGCTTGTGGAAGTGAAAATAACTCTCTCTACCTGTACTATAAAGGACTTTCT
AAGACTTTGCTAACTTTTAAGTTTGATACAGTCAAAAGTGTTCTCGACAAAGACCGAAAAGAAGATGATACAAATGAATTTGTTAGTGCT
GTGTGCTGGAGGGCACTACCAGATGGGGAGTCCAATGTGCTGATTGCTGCTAACAGTCAGGGTACAATTAAGGTGCTAGAATTGGTATGA
AGGGTTAACTCAAGTCAAATTGTACTTGATCCTGCTGAAATACATCTGCAGCTGACAATGAGAGAAGAAACAGAAAATGTCATGTGATGT
CTCTCCCCAAAGTCATCATGGGTTTTGGATTTGTTTTGAATATTTTTTTCTTTTTTTCTTTTCCCTCCTTTATGACCTTTGGGACATTGG
GAATACCCAGCCAACTCTCCACCATCAATGTAACTCCATGGACATTGCTGCTCTTGGTGGTGTTATCTAATTTTTGTGATAGGGAAACAA

>In-frame_ENST00000553834_ENST00000367669_61N_DEGS2_chr14_100625842_-_RFWD2_chr1_176055026_length(amino acids)=365AA_start in transcript=162_stop in transcript=1259
MEQCYFSTRMSRISDDSRTASQLDEFQECLSKFTRYNSVRPLATLSYASDLYNGSSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDTVIQD
AVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLD
NSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSF
KGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEFVSAVCWRALPDGESNVLIAANSQGTIK

--------------------------------------------------------------
>In-frame_ENST00000553834_ENST00000308769_61N_DEGS2_chr14_100625842_-_RFWD2_chr1_176055026_length(transcript)=1260nt_BP=90nt
GCCCCACCATGGGCAACAGCGCGAGCCGCAGCGACTTCGAGTGGGTCTACACCGACCAGCCGCACACGCAGCGGCGCAAGGAGATACTGG
ACAAAGAAACAGCCTTGGTATAATAGCACGTTAGCATCAAGACGAAAACGACTTACTGCTCATTTTGAAGACTTGGAGCAGTGTTACTTT
TCTACAAGGATGTCTCGTATCTCAGATGACAGTCGAACTGCAAGCCAGTTGGATGAATTTCAGGAATGCTTGTCCAAGTTTACTCGATAT
AATTCAGTACGACCTTTAGCCACATTGTCATATGCTAGTGATCTCTATAATGGTTCCAGTATAGTCTCTAGTATTGAATTTGACCGGGAT
TGTGACTATTTTGCGATTGCTGGAGTTACAAAGAAGATTAAAGTCTATGAATATGACACTGTCATCCAGGATGCAGTGGATATTCATTAC
CCTGAGAATGAAATGACCTGCAATTCGAAAATCAGCTGTATCAGTTGGAGTAGTTACCATAAGAACCTGTTAGCTAGCAGTGATTATGAA
GGCACTGTTATTTTATGGGATGGATTCACAGGACAGAGGTCAAAGGTCTATCAGGAGCATGAGAAGAGGTGTTGGAGTGTTGACTTTAAT
TTGATGGATCCTAAACTCTTGGCTTCAGGTTCTGATGATGCAAAAGTGAAGCTGTGGTCTACCAATCTAGACAACTCAGTGGCAAGCATT
GAGGCAAAGGCTAATGTGTGCTGTGTTAAATTCAGCCCCTCTTCCAGATACCATTTGGCTTTCGGCTGTGCAGATCACTGTGTCCACTAC
TATGATCTTCGTAACACTAAACAGCCAATCATGGTATTCAAAGGACACCGTAAAGCAGTCTCTTATGCAAAGTTTGTGAGTGGTGAGGAA
ATTGTCTCTGCCTCAACAGACAGTCAGCTAAAACTGTGGAATGTAGGGAAACCATACTGCCTACGTTCCTTCAAGGGTCATATCAATGAA
AAAAACTTTGTAGGCCTGGCTTCCAATGGAGATTATATAGCTTGTGGAAGTGAAAATAACTCTCTCTACCTGTACTATAAAGGACTTTCT
AAGACTTTGCTAACTTTTAAGTTTGATACAGTCAAAAGTGTTCTCGACAAAGACCGAAAAGAAGATGATACAAATGAATTTGTTAGTGCT
GTGTGCTGGAGGGCACTACCAGATGGGGAGTCCAATGTGCTGATTGCTGCTAACAGTCAGGGTACAATTAAGGTGCTAGAATTGGTATGA

>In-frame_ENST00000553834_ENST00000308769_61N_DEGS2_chr14_100625842_-_RFWD2_chr1_176055026_length(amino acids)=365AA_start in transcript=162_stop in transcript=1259
MEQCYFSTRMSRISDDSRTASQLDEFQECLSKFTRYNSVRPLATLSYASDLYNGSSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDTVIQD
AVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLD
NSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSF
KGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEFVSAVCWRALPDGESNVLIAANSQGTIK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for DEGS2-RFWD2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	RFWD2	chr14:100625842	chr1:176055026	ENST00000308769		7	19	643_645	318.0	708.0	TRIB1
Tgene	RFWD2	chr14:100625842	chr1:176055026	ENST00000367669		8	20	643_645	342.0	732.0	TRIB1

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for DEGS2-RFWD2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for DEGS2-RFWD2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source