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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DEK-DEK (FusionGDB2 ID:22163)

Fusion Gene Summary for DEK-DEK

check button Fusion gene summary
Fusion gene informationFusion gene name: DEK-DEK
Fusion gene ID: 22163
HgeneTgene
Gene symbol

DEK

DEK

Gene ID

7913

7913

Gene nameDEK proto-oncogeneDEK proto-oncogene
SynonymsD6S231ED6S231E
Cytomap

6p22.3

6p22.3

Type of geneprotein-codingprotein-coding
Descriptionprotein DEKDEK oncogene (DNA binding)protein DEKDEK oncogene (DNA binding)
Modification date2020031320200313
UniProtAcc.

P35659

Ensembl transtripts involved in fusion geneENST00000397239, ENST00000244776, 
ENST00000397239, ENST00000244776, 
Fusion gene scores* DoF score11 X 13 X 6=8585 X 9 X 3=135
# samples 159
** MAII scorelog2(15/858*10)=-2.51601514700366
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/135*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DEK [Title/Abstract] AND DEK [Title/Abstract] AND fusion [Title/Abstract]

Role of the DEK oncogene in the development of squamous cell carcinoma. (pmid: 32656741)
Most frequent breakpointDEK(18224734)-DEK(18224836), # samples:1
DEK(18225161)-DEK(18225235), # samples:1
DEK(18224464)-DEK(18225752), # samples:1
DEK(18258274)-DEK(18258561), # samples:1
DEK(18258638)-DEK(18236683), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DEK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DEK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABF034427DEKchr6

18224734

+DEKchr6

18224836

-
ChiTaRS5.0N/ABM466063DEKchr6

18225161

-DEKchr6

18225235

+
ChiTaRS5.0N/ABQ214682DEKchr6

18224464

+DEKchr6

18225752

-
ChiTaRS5.0N/AEC457309DEKchr6

18258274

-DEKchr6

18258561

+
ChiTaRS5.0N/AL44569DEKchr6

18258638

+DEKchr6

18236683

+


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Fusion Gene ORF analysis for DEK-DEK

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000397239ENST00000397239DEKchr6

18224734

+DEKchr6

18224836

-
intron-intronENST00000397239ENST00000244776DEKchr6

18224734

+DEKchr6

18224836

-
intron-3UTRENST00000244776ENST00000397239DEKchr6

18224734

+DEKchr6

18224836

-
intron-intronENST00000244776ENST00000244776DEKchr6

18224734

+DEKchr6

18224836

-
intron-3UTRENST00000397239ENST00000397239DEKchr6

18225161

-DEKchr6

18225235

+
intron-intronENST00000397239ENST00000244776DEKchr6

18225161

-DEKchr6

18225235

+
intron-3UTRENST00000244776ENST00000397239DEKchr6

18225161

-DEKchr6

18225235

+
intron-intronENST00000244776ENST00000244776DEKchr6

18225161

-DEKchr6

18225235

+
intron-3UTRENST00000397239ENST00000397239DEKchr6

18224464

+DEKchr6

18225752

-
intron-3UTRENST00000397239ENST00000244776DEKchr6

18224464

+DEKchr6

18225752

-
intron-3UTRENST00000244776ENST00000397239DEKchr6

18224464

+DEKchr6

18225752

-
intron-3UTRENST00000244776ENST00000244776DEKchr6

18224464

+DEKchr6

18225752

-
intron-3CDSENST00000397239ENST00000397239DEKchr6

18258274

-DEKchr6

18258561

+
intron-intronENST00000397239ENST00000244776DEKchr6

18258274

-DEKchr6

18258561

+
intron-3CDSENST00000244776ENST00000397239DEKchr6

18258274

-DEKchr6

18258561

+
intron-intronENST00000244776ENST00000244776DEKchr6

18258274

-DEKchr6

18258561

+
intron-intronENST00000397239ENST00000397239DEKchr6

18258638

+DEKchr6

18236683

+
intron-intronENST00000397239ENST00000244776DEKchr6

18258638

+DEKchr6

18236683

+
intron-intronENST00000244776ENST00000397239DEKchr6

18258638

+DEKchr6

18236683

+
intron-intronENST00000244776ENST00000244776DEKchr6

18258638

+DEKchr6

18236683

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DEK-DEK


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DEKchr618258636+DEKchr618236682+0.99999936.71E-07
DEKchr618258636+DEKchr618236682+0.99999936.71E-07

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DEK-DEK


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DEK

P35659

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Involved in chromatin organization. {ECO:0000269|PubMed:17524367}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DEK-DEK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DEK-DEK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DEK-DEK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DEK-DEK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDEKC0027626Neoplasm Invasiveness2CTD_human
HgeneDEKC0006142Malignant neoplasm of breast1CTD_human
HgeneDEKC0027627Neoplasm Metastasis1CTD_human
HgeneDEKC0678222Breast Carcinoma1CTD_human
HgeneDEKC1257931Mammary Neoplasms, Human1CTD_human
HgeneDEKC1458155Mammary Neoplasms1CTD_human
HgeneDEKC4704874Mammary Carcinoma, Human1CTD_human
TgeneDEKC0027626Neoplasm Invasiveness2CTD_human
TgeneDEKC0006142Malignant neoplasm of breast1CTD_human
TgeneDEKC0027627Neoplasm Metastasis1CTD_human
TgeneDEKC0678222Breast Carcinoma1CTD_human
TgeneDEKC1257931Mammary Neoplasms, Human1CTD_human
TgeneDEKC1458155Mammary Neoplasms1CTD_human
TgeneDEKC4704874Mammary Carcinoma, Human1CTD_human