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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DENND1B-ATP6V1G3 (FusionGDB2 ID:22196)

Fusion Gene Summary for DENND1B-ATP6V1G3

check button Fusion gene summary
Fusion gene informationFusion gene name: DENND1B-ATP6V1G3
Fusion gene ID: 22196
HgeneTgene
Gene symbol

DENND1B

ATP6V1G3

Gene ID

163486

127124

Gene nameDENN domain containing 1BATPase H+ transporting V1 subunit G3
SynonymsC1ORF18|C1orf218|FAM31BATP6G3|Vma10
Cytomap

1q31.3

1q31.3

Type of geneprotein-codingprotein-coding
DescriptionDENN domain-containing protein 1BDENN/MADD domain containing 1Bconnecdenn 2family with sequence similarity 31, member BV-type proton ATPase subunit G 3ATPase, H+ transporting, lysosomal (vacuolar proton pump) subunit G3ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3V-ATPase 13 kDa subunit 3V-ATPase G subunit 3V-ATPase G3 subunitV-ATPase subunit G 3vacuolar
Modification date2020032020200313
UniProtAcc

Q6P3S1

.
Ensembl transtripts involved in fusion geneENST00000400967, ENST00000235453, 
ENST00000367396, ENST00000477581, 
ENST00000367382, ENST00000309309, 
ENST00000281087, ENST00000367381, 
ENST00000489986, 
Fusion gene scores* DoF score13 X 7 X 7=6372 X 2 X 2=8
# samples 163
** MAII scorelog2(16/637*10)=-1.99322146736894
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/8*10)=1.90689059560852
Context

PubMed: DENND1B [Title/Abstract] AND ATP6V1G3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDENND1B(197684161)-ATP6V1G3(198498311), # samples:2
Anticipated loss of major functional domain due to fusion event.DENND1B-ATP6V1G3 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DENND1B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ATP6V1G3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A92D-01ADENND1Bchr1

197684161

-ATP6V1G3chr1

198498311

-
ChimerDB4STADTCGA-VQ-A92DDENND1Bchr1

197684160

-ATP6V1G3chr1

198498311

-
ChimerDB4STADTCGA-VQ-A92D-01ADENND1Bchr1

197684161

-ATP6V1G3chr1

198498311

-


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Fusion Gene ORF analysis for DENND1B-ATP6V1G3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000400967ENST00000367382DENND1Bchr1

197684161

-ATP6V1G3chr1

198498311

-
In-frameENST00000400967ENST00000309309DENND1Bchr1

197684161

-ATP6V1G3chr1

198498311

-
Frame-shiftENST00000400967ENST00000281087DENND1Bchr1

197684161

-ATP6V1G3chr1

198498311

-
Frame-shiftENST00000400967ENST00000367381DENND1Bchr1

197684161

-ATP6V1G3chr1

198498311

-
Frame-shiftENST00000400967ENST00000489986DENND1Bchr1

197684161

-ATP6V1G3chr1

198498311

-
Frame-shiftENST00000235453ENST00000367382DENND1Bchr1

197684161

-ATP6V1G3chr1

198498311

-
Frame-shiftENST00000235453ENST00000309309DENND1Bchr1

197684161

-ATP6V1G3chr1

198498311

-
Frame-shiftENST00000235453ENST00000281087DENND1Bchr1

197684161

-ATP6V1G3chr1

198498311

-
Frame-shiftENST00000235453ENST00000367381DENND1Bchr1

197684161

-ATP6V1G3chr1

198498311

-
Frame-shiftENST00000235453ENST00000489986DENND1Bchr1

197684161

-ATP6V1G3chr1

198498311

-
Frame-shiftENST00000367396ENST00000367382DENND1Bchr1

197684161

-ATP6V1G3chr1

198498311

-
In-frameENST00000367396ENST00000309309DENND1Bchr1

197684161

-ATP6V1G3chr1

198498311

-
Frame-shiftENST00000367396ENST00000281087DENND1Bchr1

197684161

-ATP6V1G3chr1

198498311

-
Frame-shiftENST00000367396ENST00000367381DENND1Bchr1

197684161

-ATP6V1G3chr1

198498311

-
Frame-shiftENST00000367396ENST00000489986DENND1Bchr1

197684161

-ATP6V1G3chr1

198498311

-
intron-3CDSENST00000477581ENST00000367382DENND1Bchr1

197684161

-ATP6V1G3chr1

198498311

-
intron-3CDSENST00000477581ENST00000309309DENND1Bchr1

197684161

-ATP6V1G3chr1

198498311

-
intron-3CDSENST00000477581ENST00000281087DENND1Bchr1

197684161

-ATP6V1G3chr1

198498311

-
intron-3CDSENST00000477581ENST00000367381DENND1Bchr1

197684161

-ATP6V1G3chr1

198498311

-
intron-3CDSENST00000477581ENST00000489986DENND1Bchr1

197684161

-ATP6V1G3chr1

198498311

-
Frame-shiftENST00000400967ENST00000367382DENND1Bchr1

197684160

-ATP6V1G3chr1

198498311

-
In-frameENST00000400967ENST00000309309DENND1Bchr1

197684160

-ATP6V1G3chr1

198498311

-
Frame-shiftENST00000400967ENST00000281087DENND1Bchr1

197684160

-ATP6V1G3chr1

198498311

-
Frame-shiftENST00000400967ENST00000367381DENND1Bchr1

197684160

-ATP6V1G3chr1

198498311

-
Frame-shiftENST00000400967ENST00000489986DENND1Bchr1

197684160

-ATP6V1G3chr1

198498311

-
Frame-shiftENST00000235453ENST00000367382DENND1Bchr1

197684160

-ATP6V1G3chr1

198498311

-
Frame-shiftENST00000235453ENST00000309309DENND1Bchr1

197684160

-ATP6V1G3chr1

198498311

-
Frame-shiftENST00000235453ENST00000281087DENND1Bchr1

197684160

-ATP6V1G3chr1

198498311

-
Frame-shiftENST00000235453ENST00000367381DENND1Bchr1

197684160

-ATP6V1G3chr1

198498311

-
Frame-shiftENST00000235453ENST00000489986DENND1Bchr1

197684160

-ATP6V1G3chr1

198498311

-
Frame-shiftENST00000367396ENST00000367382DENND1Bchr1

197684160

-ATP6V1G3chr1

198498311

-
In-frameENST00000367396ENST00000309309DENND1Bchr1

197684160

-ATP6V1G3chr1

198498311

-
Frame-shiftENST00000367396ENST00000281087DENND1Bchr1

197684160

-ATP6V1G3chr1

198498311

-
Frame-shiftENST00000367396ENST00000367381DENND1Bchr1

197684160

-ATP6V1G3chr1

198498311

-
Frame-shiftENST00000367396ENST00000489986DENND1Bchr1

197684160

-ATP6V1G3chr1

198498311

-
intron-3CDSENST00000477581ENST00000367382DENND1Bchr1

197684160

-ATP6V1G3chr1

198498311

-
intron-3CDSENST00000477581ENST00000309309DENND1Bchr1

197684160

-ATP6V1G3chr1

198498311

-
intron-3CDSENST00000477581ENST00000281087DENND1Bchr1

197684160

-ATP6V1G3chr1

198498311

-
intron-3CDSENST00000477581ENST00000367381DENND1Bchr1

197684160

-ATP6V1G3chr1

198498311

-
intron-3CDSENST00000477581ENST00000489986DENND1Bchr1

197684160

-ATP6V1G3chr1

198498311

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000400967DENND1Bchr1197684161-ENST00000309309ATP6V1G3chr1198498311-5409629370113
ENST00000367396DENND1Bchr1197684161-ENST00000309309ATP6V1G3chr1198498311-7402963342111
ENST00000400967DENND1Bchr1197684160-ENST00000309309ATP6V1G3chr1198498311-5409629370113
ENST00000367396DENND1Bchr1197684160-ENST00000309309ATP6V1G3chr1198498311-7402963342111

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000400967ENST00000309309DENND1Bchr1197684161-ATP6V1G3chr1198498311-0.0608188140.9391812
ENST00000367396ENST00000309309DENND1Bchr1197684161-ATP6V1G3chr1198498311-0.0881801840.9118198
ENST00000400967ENST00000309309DENND1Bchr1197684160-ATP6V1G3chr1198498311-0.0608188140.9391812
ENST00000367396ENST00000309309DENND1Bchr1197684160-ATP6V1G3chr1198498311-0.0881801840.9118198

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Fusion Genomic Features for DENND1B-ATP6V1G3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DENND1B-ATP6V1G3


check button Go to

FGviewer for the breakpoints of chr1:197684161-chr1:198498311

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DENND1B

Q6P3S1

.
FUNCTION: Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells (PubMed:20154091, PubMed:20937701, PubMed:24520163, PubMed:26774822). Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form (PubMed:20154091, PubMed:20937701). Plays a role in clathrin-mediated endocytosis (PubMed:20154091). Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity (PubMed:26774822). Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells (PubMed:26774822). {ECO:0000269|PubMed:20154091, ECO:0000269|PubMed:20937701, ECO:0000269|PubMed:24520163, ECO:0000269|PubMed:26774822}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDENND1Bchr1:197684160chr1:198498311ENST00000235453-41614_14332.0397.0DomainuDENN
HgeneDENND1Bchr1:197684160chr1:198498311ENST00000235453-416180_31632.0397.0DomaincDENN
HgeneDENND1Bchr1:197684160chr1:198498311ENST00000235453-416318_39532.0397.0DomaindDENN
HgeneDENND1Bchr1:197684160chr1:198498311ENST00000367396-31614_14342.0427.0DomainuDENN
HgeneDENND1Bchr1:197684160chr1:198498311ENST00000367396-316180_31642.0427.0DomaincDENN
HgeneDENND1Bchr1:197684160chr1:198498311ENST00000367396-316318_39542.0427.0DomaindDENN
HgeneDENND1Bchr1:197684160chr1:198498311ENST00000400967-21414_14332.0397.0DomainuDENN
HgeneDENND1Bchr1:197684160chr1:198498311ENST00000400967-214180_31632.0397.0DomaincDENN
HgeneDENND1Bchr1:197684160chr1:198498311ENST00000400967-214318_39532.0397.0DomaindDENN
HgeneDENND1Bchr1:197684161chr1:198498311ENST00000235453-41614_14332.0397.0DomainuDENN
HgeneDENND1Bchr1:197684161chr1:198498311ENST00000235453-416180_31632.0397.0DomaincDENN
HgeneDENND1Bchr1:197684161chr1:198498311ENST00000235453-416318_39532.0397.0DomaindDENN
HgeneDENND1Bchr1:197684161chr1:198498311ENST00000367396-31614_14342.0427.0DomainuDENN
HgeneDENND1Bchr1:197684161chr1:198498311ENST00000367396-316180_31642.0427.0DomaincDENN
HgeneDENND1Bchr1:197684161chr1:198498311ENST00000367396-316318_39542.0427.0DomaindDENN
HgeneDENND1Bchr1:197684161chr1:198498311ENST00000400967-21414_14332.0397.0DomainuDENN
HgeneDENND1Bchr1:197684161chr1:198498311ENST00000400967-214180_31632.0397.0DomaincDENN
HgeneDENND1Bchr1:197684161chr1:198498311ENST00000400967-214318_39532.0397.0DomaindDENN
HgeneDENND1Bchr1:197684160chr1:198498311ENST00000235453-416398_40232.0397.0MotifFXDXF motif
HgeneDENND1Bchr1:197684160chr1:198498311ENST00000235453-416566_57532.0397.0MotifClathrin box
HgeneDENND1Bchr1:197684160chr1:198498311ENST00000367396-316398_40242.0427.0MotifFXDXF motif
HgeneDENND1Bchr1:197684160chr1:198498311ENST00000367396-316566_57542.0427.0MotifClathrin box
HgeneDENND1Bchr1:197684160chr1:198498311ENST00000400967-214398_40232.0397.0MotifFXDXF motif
HgeneDENND1Bchr1:197684160chr1:198498311ENST00000400967-214566_57532.0397.0MotifClathrin box
HgeneDENND1Bchr1:197684161chr1:198498311ENST00000235453-416398_40232.0397.0MotifFXDXF motif
HgeneDENND1Bchr1:197684161chr1:198498311ENST00000235453-416566_57532.0397.0MotifClathrin box
HgeneDENND1Bchr1:197684161chr1:198498311ENST00000367396-316398_40242.0427.0MotifFXDXF motif
HgeneDENND1Bchr1:197684161chr1:198498311ENST00000367396-316566_57542.0427.0MotifClathrin box
HgeneDENND1Bchr1:197684161chr1:198498311ENST00000400967-214398_40232.0397.0MotifFXDXF motif
HgeneDENND1Bchr1:197684161chr1:198498311ENST00000400967-214566_57532.0397.0MotifClathrin box
TgeneATP6V1G3chr1:197684160chr1:198498311ENST00000281087145_5427.333333333333332119.0Coiled coilOntology_term=ECO:0000255
TgeneATP6V1G3chr1:197684160chr1:198498311ENST00000309309255_5442.666666666666664145.33333333333334Coiled coilOntology_term=ECO:0000255
TgeneATP6V1G3chr1:197684160chr1:198498311ENST00000367381255_5433.333333333333336125.0Coiled coilOntology_term=ECO:0000255
TgeneATP6V1G3chr1:197684160chr1:198498311ENST00000367382035_5427.333333333333332119.0Coiled coilOntology_term=ECO:0000255
TgeneATP6V1G3chr1:197684160chr1:198498311ENST00000489986145_5433.333333333333336125.0Coiled coilOntology_term=ECO:0000255
TgeneATP6V1G3chr1:197684161chr1:198498311ENST00000281087145_5427.333333333333332119.0Coiled coilOntology_term=ECO:0000255
TgeneATP6V1G3chr1:197684161chr1:198498311ENST00000309309255_5442.666666666666664145.33333333333334Coiled coilOntology_term=ECO:0000255
TgeneATP6V1G3chr1:197684161chr1:198498311ENST00000367381255_5433.333333333333336125.0Coiled coilOntology_term=ECO:0000255
TgeneATP6V1G3chr1:197684161chr1:198498311ENST00000367382035_5427.333333333333332119.0Coiled coilOntology_term=ECO:0000255
TgeneATP6V1G3chr1:197684161chr1:198498311ENST00000489986145_5433.333333333333336125.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for DENND1B-ATP6V1G3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000400967_ENST00000309309_TCGA-VQ-A92D-01A_DENND1B_chr1_197684161_-_ATP6V1G3_chr1_198498311_length(transcript)=540nt_BP=96nt
ATGGCGGCAGCTCCACGGGAGGAGAAAAGATGGCCCCAACCTGTATTTTCGAATCCTGTGGTATTGTGGAAATTCCCAGAGGACTTTGGA
GACCAGGAAAAGGAAAGCGATTGAAGCAAGCCAAGGAGGAAGCAATGGTAGAAATTGACCAGTACAGAATGCAGAGAGATAAAGAGTTTC
GACTAAAACAATCTAAGATAATGGGCTCTCAGAATAATCTCTCAGATGAAATAGAAGAACAAACACTAGGGAAGATACAAGAACTTAATG
GACACTACAATAAGTATATGGAAAGTGTGATGAACCAGCTCTTGAGCATGGTCTGTGACATGAAACCAGAAATCCATGTGAACTACAGAG
CCACCAACTAAATGTACATCACAGTTTTCAAGAAAAAAAAAGGTGTGTGAGTGCCACCTGGTTGCTTATGGCTTCGTATTTTTATGTTGA
GAAATTTGAAATGAGAACCTTAAATTTACATTTACAGGAAATGTGACATAACTCATACATCGGCACTGAATTAAACAAAACAAAATACAA

>In-frame_ENST00000400967_ENST00000309309_TCGA-VQ-A92D-01A_DENND1B_chr1_197684161_-_ATP6V1G3_chr1_198498311_length(amino acids)=113AA_start in transcript=29_stop in transcript=370
MAPTCIFESCGIVEIPRGLWRPGKGKRLKQAKEEAMVEIDQYRMQRDKEFRLKQSKIMGSQNNLSDEIEEQTLGKIQELNGHYNKYMESV

--------------------------------------------------------------
>In-frame_ENST00000367396_ENST00000309309_TCGA-VQ-A92D-01A_DENND1B_chr1_197684161_-_ATP6V1G3_chr1_198498311_length(transcript)=740nt_BP=296nt
GCCGGGGGCGCAGCCGACATGGGCCCGCCGCCACGGCTGCTGTGAGCAGCCTCTTTCCCTGTGTGGCCGCCGGCGTGGGCGGGGACGGCG
CGACCCTCGCGCGGCCGGGCTGCGGGCTTCCAGGCCAGCGCGCGGGGGCCGGACGGACAGCCCCACACCGACATGTAACCATGGACTGCA
GGACCAAGGCAAATCCAGACAGAACCTTTGACTTGGTGTTGAAAGTGAAATGTCATGCCTCTGAAAATGAAGATCCTGTGGTATTGTGGA
AATTCCCAGAGGACTTTGGAGACCAGGAAAAGGAAAGCGATTGAAGCAAGCCAAGGAGGAAGCAATGGTAGAAATTGACCAGTACAGAAT
GCAGAGAGATAAAGAGTTTCGACTAAAACAATCTAAGATAATGGGCTCTCAGAATAATCTCTCAGATGAAATAGAAGAACAAACACTAGG
GAAGATACAAGAACTTAATGGACACTACAATAAGTATATGGAAAGTGTGATGAACCAGCTCTTGAGCATGGTCTGTGACATGAAACCAGA
AATCCATGTGAACTACAGAGCCACCAACTAAATGTACATCACAGTTTTCAAGAAAAAAAAAGGTGTGTGAGTGCCACCTGGTTGCTTATG
GCTTCGTATTTTTATGTTGAGAAATTTGAAATGAGAACCTTAAATTTACATTTACAGGAAATGTGACATAACTCATACATCGGCACTGAA

>In-frame_ENST00000367396_ENST00000309309_TCGA-VQ-A92D-01A_DENND1B_chr1_197684161_-_ATP6V1G3_chr1_198498311_length(amino acids)=111AA_start in transcript=334_stop in transcript=2
MLPPWLASIAFLFLVSKVLWEFPQYHRIFIFRGMTFHFQHQVKGSVWICLGPAVHGYMSVWGCPSGPRALAWKPAARPREGRAVPAHAGG

--------------------------------------------------------------
>In-frame_ENST00000400967_ENST00000309309_TCGA-VQ-A92D_DENND1B_chr1_197684160_-_ATP6V1G3_chr1_198498311_length(transcript)=540nt_BP=96nt
ATGGCGGCAGCTCCACGGGAGGAGAAAAGATGGCCCCAACCTGTATTTTCGAATCCTGTGGTATTGTGGAAATTCCCAGAGGACTTTGGA
GACCAGGAAAAGGAAAGCGATTGAAGCAAGCCAAGGAGGAAGCAATGGTAGAAATTGACCAGTACAGAATGCAGAGAGATAAAGAGTTTC
GACTAAAACAATCTAAGATAATGGGCTCTCAGAATAATCTCTCAGATGAAATAGAAGAACAAACACTAGGGAAGATACAAGAACTTAATG
GACACTACAATAAGTATATGGAAAGTGTGATGAACCAGCTCTTGAGCATGGTCTGTGACATGAAACCAGAAATCCATGTGAACTACAGAG
CCACCAACTAAATGTACATCACAGTTTTCAAGAAAAAAAAAGGTGTGTGAGTGCCACCTGGTTGCTTATGGCTTCGTATTTTTATGTTGA
GAAATTTGAAATGAGAACCTTAAATTTACATTTACAGGAAATGTGACATAACTCATACATCGGCACTGAATTAAACAAAACAAAATACAA

>In-frame_ENST00000400967_ENST00000309309_TCGA-VQ-A92D_DENND1B_chr1_197684160_-_ATP6V1G3_chr1_198498311_length(amino acids)=113AA_start in transcript=29_stop in transcript=370
MAPTCIFESCGIVEIPRGLWRPGKGKRLKQAKEEAMVEIDQYRMQRDKEFRLKQSKIMGSQNNLSDEIEEQTLGKIQELNGHYNKYMESV

--------------------------------------------------------------
>In-frame_ENST00000367396_ENST00000309309_TCGA-VQ-A92D_DENND1B_chr1_197684160_-_ATP6V1G3_chr1_198498311_length(transcript)=740nt_BP=296nt
GCCGGGGGCGCAGCCGACATGGGCCCGCCGCCACGGCTGCTGTGAGCAGCCTCTTTCCCTGTGTGGCCGCCGGCGTGGGCGGGGACGGCG
CGACCCTCGCGCGGCCGGGCTGCGGGCTTCCAGGCCAGCGCGCGGGGGCCGGACGGACAGCCCCACACCGACATGTAACCATGGACTGCA
GGACCAAGGCAAATCCAGACAGAACCTTTGACTTGGTGTTGAAAGTGAAATGTCATGCCTCTGAAAATGAAGATCCTGTGGTATTGTGGA
AATTCCCAGAGGACTTTGGAGACCAGGAAAAGGAAAGCGATTGAAGCAAGCCAAGGAGGAAGCAATGGTAGAAATTGACCAGTACAGAAT
GCAGAGAGATAAAGAGTTTCGACTAAAACAATCTAAGATAATGGGCTCTCAGAATAATCTCTCAGATGAAATAGAAGAACAAACACTAGG
GAAGATACAAGAACTTAATGGACACTACAATAAGTATATGGAAAGTGTGATGAACCAGCTCTTGAGCATGGTCTGTGACATGAAACCAGA
AATCCATGTGAACTACAGAGCCACCAACTAAATGTACATCACAGTTTTCAAGAAAAAAAAAGGTGTGTGAGTGCCACCTGGTTGCTTATG
GCTTCGTATTTTTATGTTGAGAAATTTGAAATGAGAACCTTAAATTTACATTTACAGGAAATGTGACATAACTCATACATCGGCACTGAA

>In-frame_ENST00000367396_ENST00000309309_TCGA-VQ-A92D_DENND1B_chr1_197684160_-_ATP6V1G3_chr1_198498311_length(amino acids)=111AA_start in transcript=334_stop in transcript=2
MLPPWLASIAFLFLVSKVLWEFPQYHRIFIFRGMTFHFQHQVKGSVWICLGPAVHGYMSVWGCPSGPRALAWKPAARPREGRAVPAHAGG

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Fusion Gene PPI Analysis for DENND1B-ATP6V1G3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DENND1B-ATP6V1G3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DENND1B-ATP6V1G3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDENND1BC0008312Primary biliary cirrhosis1CTD_human
HgeneDENND1BC0010346Crohn Disease1CTD_human
HgeneDENND1BC0023892Biliary cirrhosis1CTD_human
HgeneDENND1BC0156147Crohn's disease of large bowel1CTD_human
HgeneDENND1BC0238065Secondary Biliary Cholangitis1CTD_human
HgeneDENND1BC0267380Crohn's disease of the ileum1CTD_human
HgeneDENND1BC0678202Regional enteritis1CTD_human
HgeneDENND1BC0949272IIeocolitis1CTD_human
HgeneDENND1BC4551595Biliary Cirrhosis, Primary, 11CTD_human