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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DENND5A-PPFIBP2 (FusionGDB2 ID:22256)

Fusion Gene Summary for DENND5A-PPFIBP2

check button Fusion gene summary
Fusion gene informationFusion gene name: DENND5A-PPFIBP2
Fusion gene ID: 22256
HgeneTgene
Gene symbol

DENND5A

PPFIBP2

Gene ID

23258

8495

Gene nameDENN domain containing 5APPFIA binding protein 2
SynonymsEIEE49|RAB6IP1Cclp1
Cytomap

11p15.4

11p15.4

Type of geneprotein-codingprotein-coding
DescriptionDENN domain-containing protein 5ADENN/MADD domain containing 5ARAB6 interacting protein 1rab6-interacting protein 1liprin-beta-2PTPRF interacting protein, binding protein 2 (liprin beta 2)liprin beta 2protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2
Modification date2020031320200313
UniProtAcc

Q6IQ26

.
Ensembl transtripts involved in fusion geneENST00000328194, ENST00000530044, 
ENST00000527700, ENST00000526523, 
ENST00000299492, ENST00000533792, 
ENST00000528883, ENST00000530181, 
ENST00000530582, 
Fusion gene scores* DoF score12 X 10 X 5=6007 X 7 X 3=147
# samples 147
** MAII scorelog2(14/600*10)=-2.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/147*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DENND5A [Title/Abstract] AND PPFIBP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDENND5A(9286507)-PPFIBP2(7631521), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DENND5A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PPFIBP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABI669204DENND5Achr11

9286507

-PPFIBP2chr11

7631521

+


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Fusion Gene ORF analysis for DENND5A-PPFIBP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000328194ENST00000299492DENND5Achr11

9286507

-PPFIBP2chr11

7631521

+
In-frameENST00000328194ENST00000533792DENND5Achr11

9286507

-PPFIBP2chr11

7631521

+
In-frameENST00000328194ENST00000528883DENND5Achr11

9286507

-PPFIBP2chr11

7631521

+
In-frameENST00000328194ENST00000530181DENND5Achr11

9286507

-PPFIBP2chr11

7631521

+
5CDS-intronENST00000328194ENST00000530582DENND5Achr11

9286507

-PPFIBP2chr11

7631521

+
In-frameENST00000530044ENST00000299492DENND5Achr11

9286507

-PPFIBP2chr11

7631521

+
In-frameENST00000530044ENST00000533792DENND5Achr11

9286507

-PPFIBP2chr11

7631521

+
In-frameENST00000530044ENST00000528883DENND5Achr11

9286507

-PPFIBP2chr11

7631521

+
In-frameENST00000530044ENST00000530181DENND5Achr11

9286507

-PPFIBP2chr11

7631521

+
5CDS-intronENST00000530044ENST00000530582DENND5Achr11

9286507

-PPFIBP2chr11

7631521

+
intron-3CDSENST00000527700ENST00000299492DENND5Achr11

9286507

-PPFIBP2chr11

7631521

+
intron-3CDSENST00000527700ENST00000533792DENND5Achr11

9286507

-PPFIBP2chr11

7631521

+
intron-3CDSENST00000527700ENST00000528883DENND5Achr11

9286507

-PPFIBP2chr11

7631521

+
intron-3CDSENST00000527700ENST00000530181DENND5Achr11

9286507

-PPFIBP2chr11

7631521

+
intron-intronENST00000527700ENST00000530582DENND5Achr11

9286507

-PPFIBP2chr11

7631521

+
intron-3CDSENST00000526523ENST00000299492DENND5Achr11

9286507

-PPFIBP2chr11

7631521

+
intron-3CDSENST00000526523ENST00000533792DENND5Achr11

9286507

-PPFIBP2chr11

7631521

+
intron-3CDSENST00000526523ENST00000528883DENND5Achr11

9286507

-PPFIBP2chr11

7631521

+
intron-3CDSENST00000526523ENST00000530181DENND5Achr11

9286507

-PPFIBP2chr11

7631521

+
intron-intronENST00000526523ENST00000530582DENND5Achr11

9286507

-PPFIBP2chr11

7631521

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000328194DENND5Achr119286507-ENST00000299492PPFIBP2chr117631521+31134303762574732
ENST00000328194DENND5Achr119286507-ENST00000533792PPFIBP2chr117631521+31174303762574732
ENST00000328194DENND5Achr119286507-ENST00000528883PPFIBP2chr117631521+27084303762574732
ENST00000328194DENND5Achr119286507-ENST00000530181PPFIBP2chr117631521+31174303762574732
ENST00000530044DENND5Achr119286507-ENST00000299492PPFIBP2chr117631521+2810127732271732
ENST00000530044DENND5Achr119286507-ENST00000533792PPFIBP2chr117631521+2814127732271732
ENST00000530044DENND5Achr119286507-ENST00000528883PPFIBP2chr117631521+2405127732271732
ENST00000530044DENND5Achr119286507-ENST00000530181PPFIBP2chr117631521+2814127732271732

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000328194ENST00000299492DENND5Achr119286507-PPFIBP2chr117631521+0.0027431050.99725693
ENST00000328194ENST00000533792DENND5Achr119286507-PPFIBP2chr117631521+0.0028121770.9971878
ENST00000328194ENST00000528883DENND5Achr119286507-PPFIBP2chr117631521+0.0037720560.996228
ENST00000328194ENST00000530181DENND5Achr119286507-PPFIBP2chr117631521+0.0028121770.9971878
ENST00000530044ENST00000299492DENND5Achr119286507-PPFIBP2chr117631521+0.0022925240.9977075
ENST00000530044ENST00000533792DENND5Achr119286507-PPFIBP2chr117631521+0.0023550370.99764496
ENST00000530044ENST00000528883DENND5Achr119286507-PPFIBP2chr117631521+0.0030612590.9969387
ENST00000530044ENST00000530181DENND5Achr119286507-PPFIBP2chr117631521+0.0023550370.99764496

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Fusion Genomic Features for DENND5A-PPFIBP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DENND5Achr119286507-PPFIBP2chr117631521+1.25E-141
DENND5Achr119286507-PPFIBP2chr117631521+1.25E-141

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DENND5A-PPFIBP2


check button Go to

FGviewer for the breakpoints of chr11:9286507-chr11:7631521

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DENND5A

Q6IQ26

.
FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:G3V7Q0, ECO:0000269|PubMed:20937701}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDENND5Achr11:9286507chr11:7631521ENST00000328194-1233_936.3333333333333361288.0Compositional biasNote=Poly-Gly
HgeneDENND5Achr11:9286507chr11:7631521ENST00000530044-1233_936.3333333333333361242.0Compositional biasNote=Poly-Gly
TgenePPFIBP2chr11:9286507chr11:7631521ENST00000528883121101_31350.0765.0Coiled coilOntology_term=ECO:0000269
TgenePPFIBP2chr11:9286507chr11:7631521ENST00000530181020101_31319.0734.0Coiled coilOntology_term=ECO:0000269
TgenePPFIBP2chr11:9286507chr11:7631521ENST00000299492424558_622162.0877.0DomainSAM 1
TgenePPFIBP2chr11:9286507chr11:7631521ENST00000299492424630_693162.0877.0DomainSAM 2
TgenePPFIBP2chr11:9286507chr11:7631521ENST00000299492424718_783162.0877.0DomainSAM 3
TgenePPFIBP2chr11:9286507chr11:7631521ENST00000528883121558_62250.0765.0DomainSAM 1
TgenePPFIBP2chr11:9286507chr11:7631521ENST00000528883121630_69350.0765.0DomainSAM 2
TgenePPFIBP2chr11:9286507chr11:7631521ENST00000528883121718_78350.0765.0DomainSAM 3
TgenePPFIBP2chr11:9286507chr11:7631521ENST00000530181020558_62219.0734.0DomainSAM 1
TgenePPFIBP2chr11:9286507chr11:7631521ENST00000530181020630_69319.0734.0DomainSAM 2
TgenePPFIBP2chr11:9286507chr11:7631521ENST00000530181020718_78319.0734.0DomainSAM 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDENND5Achr11:9286507chr11:7631521ENST00000328194-123593_59836.3333333333333361288.0Compositional biasNote=Poly-Asp
HgeneDENND5Achr11:9286507chr11:7631521ENST00000530044-123593_59836.3333333333333361242.0Compositional biasNote=Poly-Asp
HgeneDENND5Achr11:9286507chr11:7631521ENST00000328194-1231134_128236.3333333333333361288.0DomainRUN 2
HgeneDENND5Achr11:9286507chr11:7631521ENST00000328194-123278_41436.3333333333333361288.0DomaincDENN
HgeneDENND5Achr11:9286507chr11:7631521ENST00000328194-123416_59836.3333333333333361288.0DomaindDENN
HgeneDENND5Achr11:9286507chr11:7631521ENST00000328194-12357_25936.3333333333333361288.0DomainuDENN
HgeneDENND5Achr11:9286507chr11:7631521ENST00000328194-123787_95036.3333333333333361288.0DomainRUN 1
HgeneDENND5Achr11:9286507chr11:7631521ENST00000328194-123954_106236.3333333333333361288.0DomainPLAT
HgeneDENND5Achr11:9286507chr11:7631521ENST00000530044-1231134_128236.3333333333333361242.0DomainRUN 2
HgeneDENND5Achr11:9286507chr11:7631521ENST00000530044-123278_41436.3333333333333361242.0DomaincDENN
HgeneDENND5Achr11:9286507chr11:7631521ENST00000530044-123416_59836.3333333333333361242.0DomaindDENN
HgeneDENND5Achr11:9286507chr11:7631521ENST00000530044-12357_25936.3333333333333361242.0DomainuDENN
HgeneDENND5Achr11:9286507chr11:7631521ENST00000530044-123787_95036.3333333333333361242.0DomainRUN 1
HgeneDENND5Achr11:9286507chr11:7631521ENST00000530044-123954_106236.3333333333333361242.0DomainPLAT
TgenePPFIBP2chr11:9286507chr11:7631521ENST00000299492424101_313162.0877.0Coiled coilOntology_term=ECO:0000269


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Fusion Gene Sequence for DENND5A-PPFIBP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000328194_ENST00000299492_BI669204_DENND5A_chr11_9286507_-_PPFIBP2_chr11_7631521_length(transcript)=3113nt_BP=430nt
GAGGAGGGTCACGGTGGGGGCTGTCCACGCGCTCTCCGCCCTTCTCCAGGCTCGCTCGGGCCGCGGCGCTCTCGGCTAGCTGCAGCGGCG
GCGGCGCGGAGGGGAAGGCATCCAGGATGCGGTGCGGGGCGGCCCGGTGCCCCCCCGCCCCGTCACGGCAGCCGCGGCGGCCGAGGGGAC
CGGGCCAGGGCCGGGGGCGGCGGCCCGAGCCGCGGTAGCGGCGGCGGCGGGAGGGGCGGCCTGAGGGCGGACGGGCGGGCGCCCGGGTTG
CGGGGGCTCGGTGCCGCTCCGCACTGCCCGGCCGGTCTCGGCCCCGGCGCCATGAGTGGCGGCGGCGGCGGAGGGGGCTCGGCGCCCAGT
CGCTTCGCCGACTACTTTGTCATCTGCGGACTGGACACGGAGACCGGGCTGGAGCCGGACGAGCTGTCGGGAGCTGCTAAGCCGCACATC
TCTTGAGACCCAGAAGCTCGATCTGATGACTGAAGTGTCTGAGCTGAAGCTCAAGCTGGTTGGCATGGAGAAGGAGCAGAGAGAGCAGGA
GGAGAAGCAGAGAAAAGCAGAGGAGTTACTGCAAGAGCTCAGGCACCTCAAAATCAAAGTGGAAGAGTTGGAAAATGAAAGGAATCAGTA
TGAATGGAAGCTAAAGGCCACTAAGGCTGAAGTCGCCCAGCTGCAAGAACAGGTGGCCCTGAAAGATGCAGAAATTGAGCGTCTGCACAG
CCAGCTCTCCCGGACAGCAGCTCTCCACAGTGAGAGTCACACAGAGAGAGACCAAGAAATTCAACGTCTGAAAATGGGGATGGAAACTTT
GCTGCTTGCCAATGAAGATAAGGACCGTCGGATAGAGGAGCTTACGGGGCTGTTAAACCAGTACCGGAAGGTAAAGGAGATTGTGATGGT
CACTCAAGGGCCTTCGGAGAGAACTCTCTCAATCAATGAAGAAGAACCGGAGGGAGGTTTCAGCAAGTGGAACGCTACAAATAAGGACCC
TGAAGAATTATTTAAACAAGAGATGCCTCCAAGATGTAGCTCTCCTACAGTGGGGCCACCTCCATTGCCACAGAAATCACTGGAAACCAG
GGCTCAGAAAAAGCTCTCTTGTAGTCTAGAAGACTTGAGAAGTGAATCTGTGGATAAGTGTATGGATGGGAACCAGCCCTTCCCGGTGTT
AGAACCCAAGGACAGCCCTTTCTTGGCGGAGCACAAATATCCCACTTTACCTGGGAAGCTTTCAGGAGCCACGCCCAATGGAGAGGCTGC
CAAATCTCCTCCCACCATCTGCCAGCCTGACGCCACGGGGAGCAGCCTGCTGAGGCTGAGAGACACAGAAAGTGGCTGGGACGACACTGC
TGTGGTCAATGACCTCTCATCCACATCATCGGGCACTGAATCAGGTCCTCAGTCTCCTCTGACACCAGATGGTAAACGGAATCCCAAAGG
CATTAAGAAGTTCTGGGGAAAAATCCGAAGAACTCAGTCAGGAAATTTCTACACTGACACGCTGGGGATGGCAGAGTTTCGACGAGGTGG
GCTCCGGGCAACCGCAGGGCCAAGACTCTCTAGGACCAGGGACTCCAAGGGACAGAAAAGTGACGCCAATGCCCCCTTTGCCCAGTGGAG
CACAGAGCGTGTGTGTGCATGGCTGGAGGACTTTGGCCTGGCTCAGTATGTGATCTTTGCCAGGCAGTGGGTATCTTCTGGCCACACCTT
ATTGACAGCCACCCCTCAGGACATGGAAAAGGAGCTAGGAATTAAGCACCCACTCCACAGGAAGAAGCTTGTTTTAGCAGTGAAAGCCAT
CAACACCAAACAGGAGGAGAAGTCTGCACTGCTAGACCACATTTGGGTGACAAGGTGGCTTGATGATATTGGCTTACCCCAGTACAAAGA
CCAGTTTCATGAATCTAGAGTTGACAGACGAATGCTGCAATACCTAACTGTGAACGATTTACTCTTCTTAAAAGTCACCAGCCAACTACA
TCATCTCAGCATCAAATGTGCCATTCACGTGCTGCATGTCAACAAGTTCAACCCCCACTGCCTGCACCGGCGGCCAGCTGATGAGAGTAA
CCTTTCTCCTTCAGAAGTTGTACAGTGGTCCAACCACAGGGTGATGGAGTGGTTACGATCTGTGGACCTGGCAGAGTATGCACCCAATCT
TCGAGGGAGTGGAGTCCATGGAGGCCTCATTATCCTGGAGCCACGCTTCACTGGGGACACCCTGGCTATGCTTCTCAACATCCCCCCACA
AAAGACGCTCCTCAGGCGCCACCTGACCACCAAGTTCAATGCCTTGATTGGTCCGGAGGCTGAACAGGAGAAGCGAGAGAAAATGGCCTC
ACCAGCTTACACACCACTGACCACCACAGCCAAAGTCCGGCCAAGGAAACTAGGATTTTCACACTTCGGAAACATAAGAAAAAAGAAGTT
CGATGAATCGACGGACTACATTTGCCCAATGGAGCCCAGTGACGGTGTCAGTGATAGTCACAGGGTCTACAGTGGCTACCGGGGCCTCAG
CCCCCTTGATGCCCCTGAACTGGATGGGCTGGACCAGGTGGGACAGATTAGCTGATGCCCTTGTCACCTGCCCTCTGTGCACCCTGAGAG
CTCACAGTAACACTGTGTGTGTCACCATATAACTGCACCTCACCCCCGCACGTGTGCATGACTCGCAGAGAATATTCCAGCAATTGTGTA
CCCCTGGGCCAGTCTCTTTGAACCCTGAGGGTGGCCAGGATCTGGAGCTGCATCTCTAAGGGGCCAGGCTTTGGGGACCATTGCCAAAGG
TGGACTCAGGAGGAAAGACACTTAAAGACACTTTTACATGTCTAGTAATTCTTGATGTTCATCTTCAGCACCAGTGGAAACACATGAACT
TCGATGCAGGTCCAGAGACCATGGACACTCCCACGAGGCTCAGCTCTCAGGCACCCCCTACACTTCAGTTGAGGGAAAAGCTCAAGTGCC
TTAGGCCCGTGGACCACAGTCTTGGCTGAGATCAAAGGGATGAGCAACAGGGACTTCTGCCACAGTGACAATGGAATTGTGTTGTGCCTT

>In-frame_ENST00000328194_ENST00000299492_BI669204_DENND5A_chr11_9286507_-_PPFIBP2_chr11_7631521_length(amino acids)=732AA_start in transcript=376_stop in transcript=2574
MSSADWTRRPGWSRTSCRELLSRTSLETQKLDLMTEVSELKLKLVGMEKEQREQEEKQRKAEELLQELRHLKIKVEELENERNQYEWKLK
ATKAEVAQLQEQVALKDAEIERLHSQLSRTAALHSESHTERDQEIQRLKMGMETLLLANEDKDRRIEELTGLLNQYRKVKEIVMVTQGPS
ERTLSINEEEPEGGFSKWNATNKDPEELFKQEMPPRCSSPTVGPPPLPQKSLETRAQKKLSCSLEDLRSESVDKCMDGNQPFPVLEPKDS
PFLAEHKYPTLPGKLSGATPNGEAAKSPPTICQPDATGSSLLRLRDTESGWDDTAVVNDLSSTSSGTESGPQSPLTPDGKRNPKGIKKFW
GKIRRTQSGNFYTDTLGMAEFRRGGLRATAGPRLSRTRDSKGQKSDANAPFAQWSTERVCAWLEDFGLAQYVIFARQWVSSGHTLLTATP
QDMEKELGIKHPLHRKKLVLAVKAINTKQEEKSALLDHIWVTRWLDDIGLPQYKDQFHESRVDRRMLQYLTVNDLLFLKVTSQLHHLSIK
CAIHVLHVNKFNPHCLHRRPADESNLSPSEVVQWSNHRVMEWLRSVDLAEYAPNLRGSGVHGGLIILEPRFTGDTLAMLLNIPPQKTLLR
RHLTTKFNALIGPEAEQEKREKMASPAYTPLTTTAKVRPRKLGFSHFGNIRKKKFDESTDYICPMEPSDGVSDSHRVYSGYRGLSPLDAP

--------------------------------------------------------------
>In-frame_ENST00000328194_ENST00000533792_BI669204_DENND5A_chr11_9286507_-_PPFIBP2_chr11_7631521_length(transcript)=3117nt_BP=430nt
GAGGAGGGTCACGGTGGGGGCTGTCCACGCGCTCTCCGCCCTTCTCCAGGCTCGCTCGGGCCGCGGCGCTCTCGGCTAGCTGCAGCGGCG
GCGGCGCGGAGGGGAAGGCATCCAGGATGCGGTGCGGGGCGGCCCGGTGCCCCCCCGCCCCGTCACGGCAGCCGCGGCGGCCGAGGGGAC
CGGGCCAGGGCCGGGGGCGGCGGCCCGAGCCGCGGTAGCGGCGGCGGCGGGAGGGGCGGCCTGAGGGCGGACGGGCGGGCGCCCGGGTTG
CGGGGGCTCGGTGCCGCTCCGCACTGCCCGGCCGGTCTCGGCCCCGGCGCCATGAGTGGCGGCGGCGGCGGAGGGGGCTCGGCGCCCAGT
CGCTTCGCCGACTACTTTGTCATCTGCGGACTGGACACGGAGACCGGGCTGGAGCCGGACGAGCTGTCGGGAGCTGCTAAGCCGCACATC
TCTTGAGACCCAGAAGCTCGATCTGATGACTGAAGTGTCTGAGCTGAAGCTCAAGCTGGTTGGCATGGAGAAGGAGCAGAGAGAGCAGGA
GGAGAAGCAGAGAAAAGCAGAGGAGTTACTGCAAGAGCTCAGGCACCTCAAAATCAAAGTGGAAGAGTTGGAAAATGAAAGGAATCAGTA
TGAATGGAAGCTAAAGGCCACTAAGGCTGAAGTCGCCCAGCTGCAAGAACAGGTGGCCCTGAAAGATGCAGAAATTGAGCGTCTGCACAG
CCAGCTCTCCCGGACAGCAGCTCTCCACAGTGAGAGTCACACAGAGAGAGACCAAGAAATTCAACGTCTGAAAATGGGGATGGAAACTTT
GCTGCTTGCCAATGAAGATAAGGACCGTCGGATAGAGGAGCTTACGGGGCTGTTAAACCAGTACCGGAAGGTAAAGGAGATTGTGATGGT
CACTCAAGGGCCTTCGGAGAGAACTCTCTCAATCAATGAAGAAGAACCGGAGGGAGGTTTCAGCAAGTGGAACGCTACAAATAAGGACCC
TGAAGAATTATTTAAACAAGAGATGCCTCCAAGATGTAGCTCTCCTACAGTGGGGCCACCTCCATTGCCACAGAAATCACTGGAAACCAG
GGCTCAGAAAAAGCTCTCTTGTAGTCTAGAAGACTTGAGAAGTGAATCTGTGGATAAGTGTATGGATGGGAACCAGCCCTTCCCGGTGTT
AGAACCCAAGGACAGCCCTTTCTTGGCGGAGCACAAATATCCCACTTTACCTGGGAAGCTTTCAGGAGCCACGCCCAATGGAGAGGCTGC
CAAATCTCCTCCCACCATCTGCCAGCCTGACGCCACGGGGAGCAGCCTGCTGAGGCTGAGAGACACAGAAAGTGGCTGGGACGACACTGC
TGTGGTCAATGACCTCTCATCCACATCATCGGGCACTGAATCAGGTCCTCAGTCTCCTCTGACACCAGATGGTAAACGGAATCCCAAAGG
CATTAAGAAGTTCTGGGGAAAAATCCGAAGAACTCAGTCAGGAAATTTCTACACTGACACGCTGGGGATGGCAGAGTTTCGACGAGGTGG
GCTCCGGGCAACCGCAGGGCCAAGACTCTCTAGGACCAGGGACTCCAAGGGACAGAAAAGTGACGCCAATGCCCCCTTTGCCCAGTGGAG
CACAGAGCGTGTGTGTGCATGGCTGGAGGACTTTGGCCTGGCTCAGTATGTGATCTTTGCCAGGCAGTGGGTATCTTCTGGCCACACCTT
ATTGACAGCCACCCCTCAGGACATGGAAAAGGAGCTAGGAATTAAGCACCCACTCCACAGGAAGAAGCTTGTTTTAGCAGTGAAAGCCAT
CAACACCAAACAGGAGGAGAAGTCTGCACTGCTAGACCACATTTGGGTGACAAGGTGGCTTGATGATATTGGCTTACCCCAGTACAAAGA
CCAGTTTCATGAATCTAGAGTTGACAGACGAATGCTGCAATACCTAACTGTGAACGATTTACTCTTCTTAAAAGTCACCAGCCAACTACA
TCATCTCAGCATCAAATGTGCCATTCACGTGCTGCATGTCAACAAGTTCAACCCCCACTGCCTGCACCGGCGGCCAGCTGATGAGAGTAA
CCTTTCTCCTTCAGAAGTTGTACAGTGGTCCAACCACAGGGTGATGGAGTGGTTACGATCTGTGGACCTGGCAGAGTATGCACCCAATCT
TCGAGGGAGTGGAGTCCATGGAGGCCTCATTATCCTGGAGCCACGCTTCACTGGGGACACCCTGGCTATGCTTCTCAACATCCCCCCACA
AAAGACGCTCCTCAGGCGCCACCTGACCACCAAGTTCAATGCCTTGATTGGTCCGGAGGCTGAACAGGAGAAGCGAGAGAAAATGGCCTC
ACCAGCTTACACACCACTGACCACCACAGCCAAAGTCCGGCCAAGGAAACTAGGATTTTCACACTTCGGAAACATAAGAAAAAAGAAGTT
CGATGAATCGACGGACTACATTTGCCCAATGGAGCCCAGTGACGGTGTCAGTGATAGTCACAGGGTCTACAGTGGCTACCGGGGCCTCAG
CCCCCTTGATGCCCCTGAACTGGATGGGCTGGACCAGGTGGGACAGATTAGCTGATGCCCTTGTCACCTGCCCTCTGTGCACCCTGAGAG
CTCACAGTAACACTGTGTGTGTCACCATATAACTGCACCTCACCCCCGCACGTGTGCATGACTCGCAGAGAATATTCCAGCAATTGTGTA
CCCCTGGGCCAGTCTCTTTGAACCCTGAGGGTGGCCAGGATCTGGAGCTGCATCTCTAAGGGGCCAGGCTTTGGGGACCATTGCCAAAGG
TGGACTCAGGAGGAAAGACACTTAAAGACACTTTTACATGTCTAGTAATTCTTGATGTTCATCTTCAGCACCAGTGGAAACACATGAACT
TCGATGCAGGTCCAGAGACCATGGACACTCCCACGAGGCTCAGCTCTCAGGCACCCCCTACACTTCAGTTGAGGGAAAAGCTCAAGTGCC
TTAGGCCCGTGGACCACAGTCTTGGCTGAGATCAAAGGGATGAGCAACAGGGACTTCTGCCACAGTGACAATGGAATTGTGTTGTGCCTT

>In-frame_ENST00000328194_ENST00000533792_BI669204_DENND5A_chr11_9286507_-_PPFIBP2_chr11_7631521_length(amino acids)=732AA_start in transcript=376_stop in transcript=2574
MSSADWTRRPGWSRTSCRELLSRTSLETQKLDLMTEVSELKLKLVGMEKEQREQEEKQRKAEELLQELRHLKIKVEELENERNQYEWKLK
ATKAEVAQLQEQVALKDAEIERLHSQLSRTAALHSESHTERDQEIQRLKMGMETLLLANEDKDRRIEELTGLLNQYRKVKEIVMVTQGPS
ERTLSINEEEPEGGFSKWNATNKDPEELFKQEMPPRCSSPTVGPPPLPQKSLETRAQKKLSCSLEDLRSESVDKCMDGNQPFPVLEPKDS
PFLAEHKYPTLPGKLSGATPNGEAAKSPPTICQPDATGSSLLRLRDTESGWDDTAVVNDLSSTSSGTESGPQSPLTPDGKRNPKGIKKFW
GKIRRTQSGNFYTDTLGMAEFRRGGLRATAGPRLSRTRDSKGQKSDANAPFAQWSTERVCAWLEDFGLAQYVIFARQWVSSGHTLLTATP
QDMEKELGIKHPLHRKKLVLAVKAINTKQEEKSALLDHIWVTRWLDDIGLPQYKDQFHESRVDRRMLQYLTVNDLLFLKVTSQLHHLSIK
CAIHVLHVNKFNPHCLHRRPADESNLSPSEVVQWSNHRVMEWLRSVDLAEYAPNLRGSGVHGGLIILEPRFTGDTLAMLLNIPPQKTLLR
RHLTTKFNALIGPEAEQEKREKMASPAYTPLTTTAKVRPRKLGFSHFGNIRKKKFDESTDYICPMEPSDGVSDSHRVYSGYRGLSPLDAP

--------------------------------------------------------------
>In-frame_ENST00000328194_ENST00000528883_BI669204_DENND5A_chr11_9286507_-_PPFIBP2_chr11_7631521_length(transcript)=2708nt_BP=430nt
GAGGAGGGTCACGGTGGGGGCTGTCCACGCGCTCTCCGCCCTTCTCCAGGCTCGCTCGGGCCGCGGCGCTCTCGGCTAGCTGCAGCGGCG
GCGGCGCGGAGGGGAAGGCATCCAGGATGCGGTGCGGGGCGGCCCGGTGCCCCCCCGCCCCGTCACGGCAGCCGCGGCGGCCGAGGGGAC
CGGGCCAGGGCCGGGGGCGGCGGCCCGAGCCGCGGTAGCGGCGGCGGCGGGAGGGGCGGCCTGAGGGCGGACGGGCGGGCGCCCGGGTTG
CGGGGGCTCGGTGCCGCTCCGCACTGCCCGGCCGGTCTCGGCCCCGGCGCCATGAGTGGCGGCGGCGGCGGAGGGGGCTCGGCGCCCAGT
CGCTTCGCCGACTACTTTGTCATCTGCGGACTGGACACGGAGACCGGGCTGGAGCCGGACGAGCTGTCGGGAGCTGCTAAGCCGCACATC
TCTTGAGACCCAGAAGCTCGATCTGATGACTGAAGTGTCTGAGCTGAAGCTCAAGCTGGTTGGCATGGAGAAGGAGCAGAGAGAGCAGGA
GGAGAAGCAGAGAAAAGCAGAGGAGTTACTGCAAGAGCTCAGGCACCTCAAAATCAAAGTGGAAGAGTTGGAAAATGAAAGGAATCAGTA
TGAATGGAAGCTAAAGGCCACTAAGGCTGAAGTCGCCCAGCTGCAAGAACAGGTGGCCCTGAAAGATGCAGAAATTGAGCGTCTGCACAG
CCAGCTCTCCCGGACAGCAGCTCTCCACAGTGAGAGTCACACAGAGAGAGACCAAGAAATTCAACGTCTGAAAATGGGGATGGAAACTTT
GCTGCTTGCCAATGAAGATAAGGACCGTCGGATAGAGGAGCTTACGGGGCTGTTAAACCAGTACCGGAAGGTAAAGGAGATTGTGATGGT
CACTCAAGGGCCTTCGGAGAGAACTCTCTCAATCAATGAAGAAGAACCGGAGGGAGGTTTCAGCAAGTGGAACGCTACAAATAAGGACCC
TGAAGAATTATTTAAACAAGAGATGCCTCCAAGATGTAGCTCTCCTACAGTGGGGCCACCTCCATTGCCACAGAAATCACTGGAAACCAG
GGCTCAGAAAAAGCTCTCTTGTAGTCTAGAAGACTTGAGAAGTGAATCTGTGGATAAGTGTATGGATGGGAACCAGCCCTTCCCGGTGTT
AGAACCCAAGGACAGCCCTTTCTTGGCGGAGCACAAATATCCCACTTTACCTGGGAAGCTTTCAGGAGCCACGCCCAATGGAGAGGCTGC
CAAATCTCCTCCCACCATCTGCCAGCCTGACGCCACGGGGAGCAGCCTGCTGAGGCTGAGAGACACAGAAAGTGGCTGGGACGACACTGC
TGTGGTCAATGACCTCTCATCCACATCATCGGGCACTGAATCAGGTCCTCAGTCTCCTCTGACACCAGATGGTAAACGGAATCCCAAAGG
CATTAAGAAGTTCTGGGGAAAAATCCGAAGAACTCAGTCAGGAAATTTCTACACTGACACGCTGGGGATGGCAGAGTTTCGACGAGGTGG
GCTCCGGGCAACCGCAGGGCCAAGACTCTCTAGGACCAGGGACTCCAAGGGACAGAAAAGTGACGCCAATGCCCCCTTTGCCCAGTGGAG
CACAGAGCGTGTGTGTGCATGGCTGGAGGACTTTGGCCTGGCTCAGTATGTGATCTTTGCCAGGCAGTGGGTATCTTCTGGCCACACCTT
ATTGACAGCCACCCCTCAGGACATGGAAAAGGAGCTAGGAATTAAGCACCCACTCCACAGGAAGAAGCTTGTTTTAGCAGTGAAAGCCAT
CAACACCAAACAGGAGGAGAAGTCTGCACTGCTAGACCACATTTGGGTGACAAGGTGGCTTGATGATATTGGCTTACCCCAGTACAAAGA
CCAGTTTCATGAATCTAGAGTTGACAGACGAATGCTGCAATACCTAACTGTGAACGATTTACTCTTCTTAAAAGTCACCAGCCAACTACA
TCATCTCAGCATCAAATGTGCCATTCACGTGCTGCATGTCAACAAGTTCAACCCCCACTGCCTGCACCGGCGGCCAGCTGATGAGAGTAA
CCTTTCTCCTTCAGAAGTTGTACAGTGGTCCAACCACAGGGTGATGGAGTGGTTACGATCTGTGGACCTGGCAGAGTATGCACCCAATCT
TCGAGGGAGTGGAGTCCATGGAGGCCTCATTATCCTGGAGCCACGCTTCACTGGGGACACCCTGGCTATGCTTCTCAACATCCCCCCACA
AAAGACGCTCCTCAGGCGCCACCTGACCACCAAGTTCAATGCCTTGATTGGTCCGGAGGCTGAACAGGAGAAGCGAGAGAAAATGGCCTC
ACCAGCTTACACACCACTGACCACCACAGCCAAAGTCCGGCCAAGGAAACTAGGATTTTCACACTTCGGAAACATAAGAAAAAAGAAGTT
CGATGAATCGACGGACTACATTTGCCCAATGGAGCCCAGTGACGGTGTCAGTGATAGTCACAGGGTCTACAGTGGCTACCGGGGCCTCAG
CCCCCTTGATGCCCCTGAACTGGATGGGCTGGACCAGGTGGGACAGATTAGCTGATGCCCTTGTCACCTGCCCTCTGTGCACCCTGAGAG
CTCACAGTAACACTGTGTGTGTCACCATATAACTGCACCTCACCCCCGCACGTGTGCATGACTCGCAGAGAATATTCCAGCAATTGTGTA

>In-frame_ENST00000328194_ENST00000528883_BI669204_DENND5A_chr11_9286507_-_PPFIBP2_chr11_7631521_length(amino acids)=732AA_start in transcript=376_stop in transcript=2574
MSSADWTRRPGWSRTSCRELLSRTSLETQKLDLMTEVSELKLKLVGMEKEQREQEEKQRKAEELLQELRHLKIKVEELENERNQYEWKLK
ATKAEVAQLQEQVALKDAEIERLHSQLSRTAALHSESHTERDQEIQRLKMGMETLLLANEDKDRRIEELTGLLNQYRKVKEIVMVTQGPS
ERTLSINEEEPEGGFSKWNATNKDPEELFKQEMPPRCSSPTVGPPPLPQKSLETRAQKKLSCSLEDLRSESVDKCMDGNQPFPVLEPKDS
PFLAEHKYPTLPGKLSGATPNGEAAKSPPTICQPDATGSSLLRLRDTESGWDDTAVVNDLSSTSSGTESGPQSPLTPDGKRNPKGIKKFW
GKIRRTQSGNFYTDTLGMAEFRRGGLRATAGPRLSRTRDSKGQKSDANAPFAQWSTERVCAWLEDFGLAQYVIFARQWVSSGHTLLTATP
QDMEKELGIKHPLHRKKLVLAVKAINTKQEEKSALLDHIWVTRWLDDIGLPQYKDQFHESRVDRRMLQYLTVNDLLFLKVTSQLHHLSIK
CAIHVLHVNKFNPHCLHRRPADESNLSPSEVVQWSNHRVMEWLRSVDLAEYAPNLRGSGVHGGLIILEPRFTGDTLAMLLNIPPQKTLLR
RHLTTKFNALIGPEAEQEKREKMASPAYTPLTTTAKVRPRKLGFSHFGNIRKKKFDESTDYICPMEPSDGVSDSHRVYSGYRGLSPLDAP

--------------------------------------------------------------
>In-frame_ENST00000328194_ENST00000530181_BI669204_DENND5A_chr11_9286507_-_PPFIBP2_chr11_7631521_length(transcript)=3117nt_BP=430nt
GAGGAGGGTCACGGTGGGGGCTGTCCACGCGCTCTCCGCCCTTCTCCAGGCTCGCTCGGGCCGCGGCGCTCTCGGCTAGCTGCAGCGGCG
GCGGCGCGGAGGGGAAGGCATCCAGGATGCGGTGCGGGGCGGCCCGGTGCCCCCCCGCCCCGTCACGGCAGCCGCGGCGGCCGAGGGGAC
CGGGCCAGGGCCGGGGGCGGCGGCCCGAGCCGCGGTAGCGGCGGCGGCGGGAGGGGCGGCCTGAGGGCGGACGGGCGGGCGCCCGGGTTG
CGGGGGCTCGGTGCCGCTCCGCACTGCCCGGCCGGTCTCGGCCCCGGCGCCATGAGTGGCGGCGGCGGCGGAGGGGGCTCGGCGCCCAGT
CGCTTCGCCGACTACTTTGTCATCTGCGGACTGGACACGGAGACCGGGCTGGAGCCGGACGAGCTGTCGGGAGCTGCTAAGCCGCACATC
TCTTGAGACCCAGAAGCTCGATCTGATGACTGAAGTGTCTGAGCTGAAGCTCAAGCTGGTTGGCATGGAGAAGGAGCAGAGAGAGCAGGA
GGAGAAGCAGAGAAAAGCAGAGGAGTTACTGCAAGAGCTCAGGCACCTCAAAATCAAAGTGGAAGAGTTGGAAAATGAAAGGAATCAGTA
TGAATGGAAGCTAAAGGCCACTAAGGCTGAAGTCGCCCAGCTGCAAGAACAGGTGGCCCTGAAAGATGCAGAAATTGAGCGTCTGCACAG
CCAGCTCTCCCGGACAGCAGCTCTCCACAGTGAGAGTCACACAGAGAGAGACCAAGAAATTCAACGTCTGAAAATGGGGATGGAAACTTT
GCTGCTTGCCAATGAAGATAAGGACCGTCGGATAGAGGAGCTTACGGGGCTGTTAAACCAGTACCGGAAGGTAAAGGAGATTGTGATGGT
CACTCAAGGGCCTTCGGAGAGAACTCTCTCAATCAATGAAGAAGAACCGGAGGGAGGTTTCAGCAAGTGGAACGCTACAAATAAGGACCC
TGAAGAATTATTTAAACAAGAGATGCCTCCAAGATGTAGCTCTCCTACAGTGGGGCCACCTCCATTGCCACAGAAATCACTGGAAACCAG
GGCTCAGAAAAAGCTCTCTTGTAGTCTAGAAGACTTGAGAAGTGAATCTGTGGATAAGTGTATGGATGGGAACCAGCCCTTCCCGGTGTT
AGAACCCAAGGACAGCCCTTTCTTGGCGGAGCACAAATATCCCACTTTACCTGGGAAGCTTTCAGGAGCCACGCCCAATGGAGAGGCTGC
CAAATCTCCTCCCACCATCTGCCAGCCTGACGCCACGGGGAGCAGCCTGCTGAGGCTGAGAGACACAGAAAGTGGCTGGGACGACACTGC
TGTGGTCAATGACCTCTCATCCACATCATCGGGCACTGAATCAGGTCCTCAGTCTCCTCTGACACCAGATGGTAAACGGAATCCCAAAGG
CATTAAGAAGTTCTGGGGAAAAATCCGAAGAACTCAGTCAGGAAATTTCTACACTGACACGCTGGGGATGGCAGAGTTTCGACGAGGTGG
GCTCCGGGCAACCGCAGGGCCAAGACTCTCTAGGACCAGGGACTCCAAGGGACAGAAAAGTGACGCCAATGCCCCCTTTGCCCAGTGGAG
CACAGAGCGTGTGTGTGCATGGCTGGAGGACTTTGGCCTGGCTCAGTATGTGATCTTTGCCAGGCAGTGGGTATCTTCTGGCCACACCTT
ATTGACAGCCACCCCTCAGGACATGGAAAAGGAGCTAGGAATTAAGCACCCACTCCACAGGAAGAAGCTTGTTTTAGCAGTGAAAGCCAT
CAACACCAAACAGGAGGAGAAGTCTGCACTGCTAGACCACATTTGGGTGACAAGGTGGCTTGATGATATTGGCTTACCCCAGTACAAAGA
CCAGTTTCATGAATCTAGAGTTGACAGACGAATGCTGCAATACCTAACTGTGAACGATTTACTCTTCTTAAAAGTCACCAGCCAACTACA
TCATCTCAGCATCAAATGTGCCATTCACGTGCTGCATGTCAACAAGTTCAACCCCCACTGCCTGCACCGGCGGCCAGCTGATGAGAGTAA
CCTTTCTCCTTCAGAAGTTGTACAGTGGTCCAACCACAGGGTGATGGAGTGGTTACGATCTGTGGACCTGGCAGAGTATGCACCCAATCT
TCGAGGGAGTGGAGTCCATGGAGGCCTCATTATCCTGGAGCCACGCTTCACTGGGGACACCCTGGCTATGCTTCTCAACATCCCCCCACA
AAAGACGCTCCTCAGGCGCCACCTGACCACCAAGTTCAATGCCTTGATTGGTCCGGAGGCTGAACAGGAGAAGCGAGAGAAAATGGCCTC
ACCAGCTTACACACCACTGACCACCACAGCCAAAGTCCGGCCAAGGAAACTAGGATTTTCACACTTCGGAAACATAAGAAAAAAGAAGTT
CGATGAATCGACGGACTACATTTGCCCAATGGAGCCCAGTGACGGTGTCAGTGATAGTCACAGGGTCTACAGTGGCTACCGGGGCCTCAG
CCCCCTTGATGCCCCTGAACTGGATGGGCTGGACCAGGTGGGACAGATTAGCTGATGCCCTTGTCACCTGCCCTCTGTGCACCCTGAGAG
CTCACAGTAACACTGTGTGTGTCACCATATAACTGCACCTCACCCCCGCACGTGTGCATGACTCGCAGAGAATATTCCAGCAATTGTGTA
CCCCTGGGCCAGTCTCTTTGAACCCTGAGGGTGGCCAGGATCTGGAGCTGCATCTCTAAGGGGCCAGGCTTTGGGGACCATTGCCAAAGG
TGGACTCAGGAGGAAAGACACTTAAAGACACTTTTACATGTCTAGTAATTCTTGATGTTCATCTTCAGCACCAGTGGAAACACATGAACT
TCGATGCAGGTCCAGAGACCATGGACACTCCCACGAGGCTCAGCTCTCAGGCACCCCCTACACTTCAGTTGAGGGAAAAGCTCAAGTGCC
TTAGGCCCGTGGACCACAGTCTTGGCTGAGATCAAAGGGATGAGCAACAGGGACTTCTGCCACAGTGACAATGGAATTGTGTTGTGCCTT

>In-frame_ENST00000328194_ENST00000530181_BI669204_DENND5A_chr11_9286507_-_PPFIBP2_chr11_7631521_length(amino acids)=732AA_start in transcript=376_stop in transcript=2574
MSSADWTRRPGWSRTSCRELLSRTSLETQKLDLMTEVSELKLKLVGMEKEQREQEEKQRKAEELLQELRHLKIKVEELENERNQYEWKLK
ATKAEVAQLQEQVALKDAEIERLHSQLSRTAALHSESHTERDQEIQRLKMGMETLLLANEDKDRRIEELTGLLNQYRKVKEIVMVTQGPS
ERTLSINEEEPEGGFSKWNATNKDPEELFKQEMPPRCSSPTVGPPPLPQKSLETRAQKKLSCSLEDLRSESVDKCMDGNQPFPVLEPKDS
PFLAEHKYPTLPGKLSGATPNGEAAKSPPTICQPDATGSSLLRLRDTESGWDDTAVVNDLSSTSSGTESGPQSPLTPDGKRNPKGIKKFW
GKIRRTQSGNFYTDTLGMAEFRRGGLRATAGPRLSRTRDSKGQKSDANAPFAQWSTERVCAWLEDFGLAQYVIFARQWVSSGHTLLTATP
QDMEKELGIKHPLHRKKLVLAVKAINTKQEEKSALLDHIWVTRWLDDIGLPQYKDQFHESRVDRRMLQYLTVNDLLFLKVTSQLHHLSIK
CAIHVLHVNKFNPHCLHRRPADESNLSPSEVVQWSNHRVMEWLRSVDLAEYAPNLRGSGVHGGLIILEPRFTGDTLAMLLNIPPQKTLLR
RHLTTKFNALIGPEAEQEKREKMASPAYTPLTTTAKVRPRKLGFSHFGNIRKKKFDESTDYICPMEPSDGVSDSHRVYSGYRGLSPLDAP

--------------------------------------------------------------
>In-frame_ENST00000530044_ENST00000299492_BI669204_DENND5A_chr11_9286507_-_PPFIBP2_chr11_7631521_length(transcript)=2810nt_BP=127nt
GGTCTCGGCCCCGGCGCCATGAGTGGCGGCGGCGGCGGAGGGGGCTCGGCGCCCAGTCGCTTCGCCGACTACTTTGTCATCTGCGGACTG
GACACGGAGACCGGGCTGGAGCCGGACGAGCTGTCGGGAGCTGCTAAGCCGCACATCTCTTGAGACCCAGAAGCTCGATCTGATGACTGA
AGTGTCTGAGCTGAAGCTCAAGCTGGTTGGCATGGAGAAGGAGCAGAGAGAGCAGGAGGAGAAGCAGAGAAAAGCAGAGGAGTTACTGCA
AGAGCTCAGGCACCTCAAAATCAAAGTGGAAGAGTTGGAAAATGAAAGGAATCAGTATGAATGGAAGCTAAAGGCCACTAAGGCTGAAGT
CGCCCAGCTGCAAGAACAGGTGGCCCTGAAAGATGCAGAAATTGAGCGTCTGCACAGCCAGCTCTCCCGGACAGCAGCTCTCCACAGTGA
GAGTCACACAGAGAGAGACCAAGAAATTCAACGTCTGAAAATGGGGATGGAAACTTTGCTGCTTGCCAATGAAGATAAGGACCGTCGGAT
AGAGGAGCTTACGGGGCTGTTAAACCAGTACCGGAAGGTAAAGGAGATTGTGATGGTCACTCAAGGGCCTTCGGAGAGAACTCTCTCAAT
CAATGAAGAAGAACCGGAGGGAGGTTTCAGCAAGTGGAACGCTACAAATAAGGACCCTGAAGAATTATTTAAACAAGAGATGCCTCCAAG
ATGTAGCTCTCCTACAGTGGGGCCACCTCCATTGCCACAGAAATCACTGGAAACCAGGGCTCAGAAAAAGCTCTCTTGTAGTCTAGAAGA
CTTGAGAAGTGAATCTGTGGATAAGTGTATGGATGGGAACCAGCCCTTCCCGGTGTTAGAACCCAAGGACAGCCCTTTCTTGGCGGAGCA
CAAATATCCCACTTTACCTGGGAAGCTTTCAGGAGCCACGCCCAATGGAGAGGCTGCCAAATCTCCTCCCACCATCTGCCAGCCTGACGC
CACGGGGAGCAGCCTGCTGAGGCTGAGAGACACAGAAAGTGGCTGGGACGACACTGCTGTGGTCAATGACCTCTCATCCACATCATCGGG
CACTGAATCAGGTCCTCAGTCTCCTCTGACACCAGATGGTAAACGGAATCCCAAAGGCATTAAGAAGTTCTGGGGAAAAATCCGAAGAAC
TCAGTCAGGAAATTTCTACACTGACACGCTGGGGATGGCAGAGTTTCGACGAGGTGGGCTCCGGGCAACCGCAGGGCCAAGACTCTCTAG
GACCAGGGACTCCAAGGGACAGAAAAGTGACGCCAATGCCCCCTTTGCCCAGTGGAGCACAGAGCGTGTGTGTGCATGGCTGGAGGACTT
TGGCCTGGCTCAGTATGTGATCTTTGCCAGGCAGTGGGTATCTTCTGGCCACACCTTATTGACAGCCACCCCTCAGGACATGGAAAAGGA
GCTAGGAATTAAGCACCCACTCCACAGGAAGAAGCTTGTTTTAGCAGTGAAAGCCATCAACACCAAACAGGAGGAGAAGTCTGCACTGCT
AGACCACATTTGGGTGACAAGGTGGCTTGATGATATTGGCTTACCCCAGTACAAAGACCAGTTTCATGAATCTAGAGTTGACAGACGAAT
GCTGCAATACCTAACTGTGAACGATTTACTCTTCTTAAAAGTCACCAGCCAACTACATCATCTCAGCATCAAATGTGCCATTCACGTGCT
GCATGTCAACAAGTTCAACCCCCACTGCCTGCACCGGCGGCCAGCTGATGAGAGTAACCTTTCTCCTTCAGAAGTTGTACAGTGGTCCAA
CCACAGGGTGATGGAGTGGTTACGATCTGTGGACCTGGCAGAGTATGCACCCAATCTTCGAGGGAGTGGAGTCCATGGAGGCCTCATTAT
CCTGGAGCCACGCTTCACTGGGGACACCCTGGCTATGCTTCTCAACATCCCCCCACAAAAGACGCTCCTCAGGCGCCACCTGACCACCAA
GTTCAATGCCTTGATTGGTCCGGAGGCTGAACAGGAGAAGCGAGAGAAAATGGCCTCACCAGCTTACACACCACTGACCACCACAGCCAA
AGTCCGGCCAAGGAAACTAGGATTTTCACACTTCGGAAACATAAGAAAAAAGAAGTTCGATGAATCGACGGACTACATTTGCCCAATGGA
GCCCAGTGACGGTGTCAGTGATAGTCACAGGGTCTACAGTGGCTACCGGGGCCTCAGCCCCCTTGATGCCCCTGAACTGGATGGGCTGGA
CCAGGTGGGACAGATTAGCTGATGCCCTTGTCACCTGCCCTCTGTGCACCCTGAGAGCTCACAGTAACACTGTGTGTGTCACCATATAAC
TGCACCTCACCCCCGCACGTGTGCATGACTCGCAGAGAATATTCCAGCAATTGTGTACCCCTGGGCCAGTCTCTTTGAACCCTGAGGGTG
GCCAGGATCTGGAGCTGCATCTCTAAGGGGCCAGGCTTTGGGGACCATTGCCAAAGGTGGACTCAGGAGGAAAGACACTTAAAGACACTT
TTACATGTCTAGTAATTCTTGATGTTCATCTTCAGCACCAGTGGAAACACATGAACTTCGATGCAGGTCCAGAGACCATGGACACTCCCA
CGAGGCTCAGCTCTCAGGCACCCCCTACACTTCAGTTGAGGGAAAAGCTCAAGTGCCTTAGGCCCGTGGACCACAGTCTTGGCTGAGATC
AAAGGGATGAGCAACAGGGACTTCTGCCACAGTGACAATGGAATTGTGTTGTGCCTTACTTCAGAGGTGGTCTCTTCTTTCTTGTAATAA

>In-frame_ENST00000530044_ENST00000299492_BI669204_DENND5A_chr11_9286507_-_PPFIBP2_chr11_7631521_length(amino acids)=732AA_start in transcript=73_stop in transcript=2271
MSSADWTRRPGWSRTSCRELLSRTSLETQKLDLMTEVSELKLKLVGMEKEQREQEEKQRKAEELLQELRHLKIKVEELENERNQYEWKLK
ATKAEVAQLQEQVALKDAEIERLHSQLSRTAALHSESHTERDQEIQRLKMGMETLLLANEDKDRRIEELTGLLNQYRKVKEIVMVTQGPS
ERTLSINEEEPEGGFSKWNATNKDPEELFKQEMPPRCSSPTVGPPPLPQKSLETRAQKKLSCSLEDLRSESVDKCMDGNQPFPVLEPKDS
PFLAEHKYPTLPGKLSGATPNGEAAKSPPTICQPDATGSSLLRLRDTESGWDDTAVVNDLSSTSSGTESGPQSPLTPDGKRNPKGIKKFW
GKIRRTQSGNFYTDTLGMAEFRRGGLRATAGPRLSRTRDSKGQKSDANAPFAQWSTERVCAWLEDFGLAQYVIFARQWVSSGHTLLTATP
QDMEKELGIKHPLHRKKLVLAVKAINTKQEEKSALLDHIWVTRWLDDIGLPQYKDQFHESRVDRRMLQYLTVNDLLFLKVTSQLHHLSIK
CAIHVLHVNKFNPHCLHRRPADESNLSPSEVVQWSNHRVMEWLRSVDLAEYAPNLRGSGVHGGLIILEPRFTGDTLAMLLNIPPQKTLLR
RHLTTKFNALIGPEAEQEKREKMASPAYTPLTTTAKVRPRKLGFSHFGNIRKKKFDESTDYICPMEPSDGVSDSHRVYSGYRGLSPLDAP

--------------------------------------------------------------
>In-frame_ENST00000530044_ENST00000533792_BI669204_DENND5A_chr11_9286507_-_PPFIBP2_chr11_7631521_length(transcript)=2814nt_BP=127nt
GGTCTCGGCCCCGGCGCCATGAGTGGCGGCGGCGGCGGAGGGGGCTCGGCGCCCAGTCGCTTCGCCGACTACTTTGTCATCTGCGGACTG
GACACGGAGACCGGGCTGGAGCCGGACGAGCTGTCGGGAGCTGCTAAGCCGCACATCTCTTGAGACCCAGAAGCTCGATCTGATGACTGA
AGTGTCTGAGCTGAAGCTCAAGCTGGTTGGCATGGAGAAGGAGCAGAGAGAGCAGGAGGAGAAGCAGAGAAAAGCAGAGGAGTTACTGCA
AGAGCTCAGGCACCTCAAAATCAAAGTGGAAGAGTTGGAAAATGAAAGGAATCAGTATGAATGGAAGCTAAAGGCCACTAAGGCTGAAGT
CGCCCAGCTGCAAGAACAGGTGGCCCTGAAAGATGCAGAAATTGAGCGTCTGCACAGCCAGCTCTCCCGGACAGCAGCTCTCCACAGTGA
GAGTCACACAGAGAGAGACCAAGAAATTCAACGTCTGAAAATGGGGATGGAAACTTTGCTGCTTGCCAATGAAGATAAGGACCGTCGGAT
AGAGGAGCTTACGGGGCTGTTAAACCAGTACCGGAAGGTAAAGGAGATTGTGATGGTCACTCAAGGGCCTTCGGAGAGAACTCTCTCAAT
CAATGAAGAAGAACCGGAGGGAGGTTTCAGCAAGTGGAACGCTACAAATAAGGACCCTGAAGAATTATTTAAACAAGAGATGCCTCCAAG
ATGTAGCTCTCCTACAGTGGGGCCACCTCCATTGCCACAGAAATCACTGGAAACCAGGGCTCAGAAAAAGCTCTCTTGTAGTCTAGAAGA
CTTGAGAAGTGAATCTGTGGATAAGTGTATGGATGGGAACCAGCCCTTCCCGGTGTTAGAACCCAAGGACAGCCCTTTCTTGGCGGAGCA
CAAATATCCCACTTTACCTGGGAAGCTTTCAGGAGCCACGCCCAATGGAGAGGCTGCCAAATCTCCTCCCACCATCTGCCAGCCTGACGC
CACGGGGAGCAGCCTGCTGAGGCTGAGAGACACAGAAAGTGGCTGGGACGACACTGCTGTGGTCAATGACCTCTCATCCACATCATCGGG
CACTGAATCAGGTCCTCAGTCTCCTCTGACACCAGATGGTAAACGGAATCCCAAAGGCATTAAGAAGTTCTGGGGAAAAATCCGAAGAAC
TCAGTCAGGAAATTTCTACACTGACACGCTGGGGATGGCAGAGTTTCGACGAGGTGGGCTCCGGGCAACCGCAGGGCCAAGACTCTCTAG
GACCAGGGACTCCAAGGGACAGAAAAGTGACGCCAATGCCCCCTTTGCCCAGTGGAGCACAGAGCGTGTGTGTGCATGGCTGGAGGACTT
TGGCCTGGCTCAGTATGTGATCTTTGCCAGGCAGTGGGTATCTTCTGGCCACACCTTATTGACAGCCACCCCTCAGGACATGGAAAAGGA
GCTAGGAATTAAGCACCCACTCCACAGGAAGAAGCTTGTTTTAGCAGTGAAAGCCATCAACACCAAACAGGAGGAGAAGTCTGCACTGCT
AGACCACATTTGGGTGACAAGGTGGCTTGATGATATTGGCTTACCCCAGTACAAAGACCAGTTTCATGAATCTAGAGTTGACAGACGAAT
GCTGCAATACCTAACTGTGAACGATTTACTCTTCTTAAAAGTCACCAGCCAACTACATCATCTCAGCATCAAATGTGCCATTCACGTGCT
GCATGTCAACAAGTTCAACCCCCACTGCCTGCACCGGCGGCCAGCTGATGAGAGTAACCTTTCTCCTTCAGAAGTTGTACAGTGGTCCAA
CCACAGGGTGATGGAGTGGTTACGATCTGTGGACCTGGCAGAGTATGCACCCAATCTTCGAGGGAGTGGAGTCCATGGAGGCCTCATTAT
CCTGGAGCCACGCTTCACTGGGGACACCCTGGCTATGCTTCTCAACATCCCCCCACAAAAGACGCTCCTCAGGCGCCACCTGACCACCAA
GTTCAATGCCTTGATTGGTCCGGAGGCTGAACAGGAGAAGCGAGAGAAAATGGCCTCACCAGCTTACACACCACTGACCACCACAGCCAA
AGTCCGGCCAAGGAAACTAGGATTTTCACACTTCGGAAACATAAGAAAAAAGAAGTTCGATGAATCGACGGACTACATTTGCCCAATGGA
GCCCAGTGACGGTGTCAGTGATAGTCACAGGGTCTACAGTGGCTACCGGGGCCTCAGCCCCCTTGATGCCCCTGAACTGGATGGGCTGGA
CCAGGTGGGACAGATTAGCTGATGCCCTTGTCACCTGCCCTCTGTGCACCCTGAGAGCTCACAGTAACACTGTGTGTGTCACCATATAAC
TGCACCTCACCCCCGCACGTGTGCATGACTCGCAGAGAATATTCCAGCAATTGTGTACCCCTGGGCCAGTCTCTTTGAACCCTGAGGGTG
GCCAGGATCTGGAGCTGCATCTCTAAGGGGCCAGGCTTTGGGGACCATTGCCAAAGGTGGACTCAGGAGGAAAGACACTTAAAGACACTT
TTACATGTCTAGTAATTCTTGATGTTCATCTTCAGCACCAGTGGAAACACATGAACTTCGATGCAGGTCCAGAGACCATGGACACTCCCA
CGAGGCTCAGCTCTCAGGCACCCCCTACACTTCAGTTGAGGGAAAAGCTCAAGTGCCTTAGGCCCGTGGACCACAGTCTTGGCTGAGATC
AAAGGGATGAGCAACAGGGACTTCTGCCACAGTGACAATGGAATTGTGTTGTGCCTTACTTCAGAGGTGGTCTCTTCTTTCTTGTAATAA

>In-frame_ENST00000530044_ENST00000533792_BI669204_DENND5A_chr11_9286507_-_PPFIBP2_chr11_7631521_length(amino acids)=732AA_start in transcript=73_stop in transcript=2271
MSSADWTRRPGWSRTSCRELLSRTSLETQKLDLMTEVSELKLKLVGMEKEQREQEEKQRKAEELLQELRHLKIKVEELENERNQYEWKLK
ATKAEVAQLQEQVALKDAEIERLHSQLSRTAALHSESHTERDQEIQRLKMGMETLLLANEDKDRRIEELTGLLNQYRKVKEIVMVTQGPS
ERTLSINEEEPEGGFSKWNATNKDPEELFKQEMPPRCSSPTVGPPPLPQKSLETRAQKKLSCSLEDLRSESVDKCMDGNQPFPVLEPKDS
PFLAEHKYPTLPGKLSGATPNGEAAKSPPTICQPDATGSSLLRLRDTESGWDDTAVVNDLSSTSSGTESGPQSPLTPDGKRNPKGIKKFW
GKIRRTQSGNFYTDTLGMAEFRRGGLRATAGPRLSRTRDSKGQKSDANAPFAQWSTERVCAWLEDFGLAQYVIFARQWVSSGHTLLTATP
QDMEKELGIKHPLHRKKLVLAVKAINTKQEEKSALLDHIWVTRWLDDIGLPQYKDQFHESRVDRRMLQYLTVNDLLFLKVTSQLHHLSIK
CAIHVLHVNKFNPHCLHRRPADESNLSPSEVVQWSNHRVMEWLRSVDLAEYAPNLRGSGVHGGLIILEPRFTGDTLAMLLNIPPQKTLLR
RHLTTKFNALIGPEAEQEKREKMASPAYTPLTTTAKVRPRKLGFSHFGNIRKKKFDESTDYICPMEPSDGVSDSHRVYSGYRGLSPLDAP

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>In-frame_ENST00000530044_ENST00000528883_BI669204_DENND5A_chr11_9286507_-_PPFIBP2_chr11_7631521_length(transcript)=2405nt_BP=127nt
GGTCTCGGCCCCGGCGCCATGAGTGGCGGCGGCGGCGGAGGGGGCTCGGCGCCCAGTCGCTTCGCCGACTACTTTGTCATCTGCGGACTG
GACACGGAGACCGGGCTGGAGCCGGACGAGCTGTCGGGAGCTGCTAAGCCGCACATCTCTTGAGACCCAGAAGCTCGATCTGATGACTGA
AGTGTCTGAGCTGAAGCTCAAGCTGGTTGGCATGGAGAAGGAGCAGAGAGAGCAGGAGGAGAAGCAGAGAAAAGCAGAGGAGTTACTGCA
AGAGCTCAGGCACCTCAAAATCAAAGTGGAAGAGTTGGAAAATGAAAGGAATCAGTATGAATGGAAGCTAAAGGCCACTAAGGCTGAAGT
CGCCCAGCTGCAAGAACAGGTGGCCCTGAAAGATGCAGAAATTGAGCGTCTGCACAGCCAGCTCTCCCGGACAGCAGCTCTCCACAGTGA
GAGTCACACAGAGAGAGACCAAGAAATTCAACGTCTGAAAATGGGGATGGAAACTTTGCTGCTTGCCAATGAAGATAAGGACCGTCGGAT
AGAGGAGCTTACGGGGCTGTTAAACCAGTACCGGAAGGTAAAGGAGATTGTGATGGTCACTCAAGGGCCTTCGGAGAGAACTCTCTCAAT
CAATGAAGAAGAACCGGAGGGAGGTTTCAGCAAGTGGAACGCTACAAATAAGGACCCTGAAGAATTATTTAAACAAGAGATGCCTCCAAG
ATGTAGCTCTCCTACAGTGGGGCCACCTCCATTGCCACAGAAATCACTGGAAACCAGGGCTCAGAAAAAGCTCTCTTGTAGTCTAGAAGA
CTTGAGAAGTGAATCTGTGGATAAGTGTATGGATGGGAACCAGCCCTTCCCGGTGTTAGAACCCAAGGACAGCCCTTTCTTGGCGGAGCA
CAAATATCCCACTTTACCTGGGAAGCTTTCAGGAGCCACGCCCAATGGAGAGGCTGCCAAATCTCCTCCCACCATCTGCCAGCCTGACGC
CACGGGGAGCAGCCTGCTGAGGCTGAGAGACACAGAAAGTGGCTGGGACGACACTGCTGTGGTCAATGACCTCTCATCCACATCATCGGG
CACTGAATCAGGTCCTCAGTCTCCTCTGACACCAGATGGTAAACGGAATCCCAAAGGCATTAAGAAGTTCTGGGGAAAAATCCGAAGAAC
TCAGTCAGGAAATTTCTACACTGACACGCTGGGGATGGCAGAGTTTCGACGAGGTGGGCTCCGGGCAACCGCAGGGCCAAGACTCTCTAG
GACCAGGGACTCCAAGGGACAGAAAAGTGACGCCAATGCCCCCTTTGCCCAGTGGAGCACAGAGCGTGTGTGTGCATGGCTGGAGGACTT
TGGCCTGGCTCAGTATGTGATCTTTGCCAGGCAGTGGGTATCTTCTGGCCACACCTTATTGACAGCCACCCCTCAGGACATGGAAAAGGA
GCTAGGAATTAAGCACCCACTCCACAGGAAGAAGCTTGTTTTAGCAGTGAAAGCCATCAACACCAAACAGGAGGAGAAGTCTGCACTGCT
AGACCACATTTGGGTGACAAGGTGGCTTGATGATATTGGCTTACCCCAGTACAAAGACCAGTTTCATGAATCTAGAGTTGACAGACGAAT
GCTGCAATACCTAACTGTGAACGATTTACTCTTCTTAAAAGTCACCAGCCAACTACATCATCTCAGCATCAAATGTGCCATTCACGTGCT
GCATGTCAACAAGTTCAACCCCCACTGCCTGCACCGGCGGCCAGCTGATGAGAGTAACCTTTCTCCTTCAGAAGTTGTACAGTGGTCCAA
CCACAGGGTGATGGAGTGGTTACGATCTGTGGACCTGGCAGAGTATGCACCCAATCTTCGAGGGAGTGGAGTCCATGGAGGCCTCATTAT
CCTGGAGCCACGCTTCACTGGGGACACCCTGGCTATGCTTCTCAACATCCCCCCACAAAAGACGCTCCTCAGGCGCCACCTGACCACCAA
GTTCAATGCCTTGATTGGTCCGGAGGCTGAACAGGAGAAGCGAGAGAAAATGGCCTCACCAGCTTACACACCACTGACCACCACAGCCAA
AGTCCGGCCAAGGAAACTAGGATTTTCACACTTCGGAAACATAAGAAAAAAGAAGTTCGATGAATCGACGGACTACATTTGCCCAATGGA
GCCCAGTGACGGTGTCAGTGATAGTCACAGGGTCTACAGTGGCTACCGGGGCCTCAGCCCCCTTGATGCCCCTGAACTGGATGGGCTGGA
CCAGGTGGGACAGATTAGCTGATGCCCTTGTCACCTGCCCTCTGTGCACCCTGAGAGCTCACAGTAACACTGTGTGTGTCACCATATAAC

>In-frame_ENST00000530044_ENST00000528883_BI669204_DENND5A_chr11_9286507_-_PPFIBP2_chr11_7631521_length(amino acids)=732AA_start in transcript=73_stop in transcript=2271
MSSADWTRRPGWSRTSCRELLSRTSLETQKLDLMTEVSELKLKLVGMEKEQREQEEKQRKAEELLQELRHLKIKVEELENERNQYEWKLK
ATKAEVAQLQEQVALKDAEIERLHSQLSRTAALHSESHTERDQEIQRLKMGMETLLLANEDKDRRIEELTGLLNQYRKVKEIVMVTQGPS
ERTLSINEEEPEGGFSKWNATNKDPEELFKQEMPPRCSSPTVGPPPLPQKSLETRAQKKLSCSLEDLRSESVDKCMDGNQPFPVLEPKDS
PFLAEHKYPTLPGKLSGATPNGEAAKSPPTICQPDATGSSLLRLRDTESGWDDTAVVNDLSSTSSGTESGPQSPLTPDGKRNPKGIKKFW
GKIRRTQSGNFYTDTLGMAEFRRGGLRATAGPRLSRTRDSKGQKSDANAPFAQWSTERVCAWLEDFGLAQYVIFARQWVSSGHTLLTATP
QDMEKELGIKHPLHRKKLVLAVKAINTKQEEKSALLDHIWVTRWLDDIGLPQYKDQFHESRVDRRMLQYLTVNDLLFLKVTSQLHHLSIK
CAIHVLHVNKFNPHCLHRRPADESNLSPSEVVQWSNHRVMEWLRSVDLAEYAPNLRGSGVHGGLIILEPRFTGDTLAMLLNIPPQKTLLR
RHLTTKFNALIGPEAEQEKREKMASPAYTPLTTTAKVRPRKLGFSHFGNIRKKKFDESTDYICPMEPSDGVSDSHRVYSGYRGLSPLDAP

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>In-frame_ENST00000530044_ENST00000530181_BI669204_DENND5A_chr11_9286507_-_PPFIBP2_chr11_7631521_length(transcript)=2814nt_BP=127nt
GGTCTCGGCCCCGGCGCCATGAGTGGCGGCGGCGGCGGAGGGGGCTCGGCGCCCAGTCGCTTCGCCGACTACTTTGTCATCTGCGGACTG
GACACGGAGACCGGGCTGGAGCCGGACGAGCTGTCGGGAGCTGCTAAGCCGCACATCTCTTGAGACCCAGAAGCTCGATCTGATGACTGA
AGTGTCTGAGCTGAAGCTCAAGCTGGTTGGCATGGAGAAGGAGCAGAGAGAGCAGGAGGAGAAGCAGAGAAAAGCAGAGGAGTTACTGCA
AGAGCTCAGGCACCTCAAAATCAAAGTGGAAGAGTTGGAAAATGAAAGGAATCAGTATGAATGGAAGCTAAAGGCCACTAAGGCTGAAGT
CGCCCAGCTGCAAGAACAGGTGGCCCTGAAAGATGCAGAAATTGAGCGTCTGCACAGCCAGCTCTCCCGGACAGCAGCTCTCCACAGTGA
GAGTCACACAGAGAGAGACCAAGAAATTCAACGTCTGAAAATGGGGATGGAAACTTTGCTGCTTGCCAATGAAGATAAGGACCGTCGGAT
AGAGGAGCTTACGGGGCTGTTAAACCAGTACCGGAAGGTAAAGGAGATTGTGATGGTCACTCAAGGGCCTTCGGAGAGAACTCTCTCAAT
CAATGAAGAAGAACCGGAGGGAGGTTTCAGCAAGTGGAACGCTACAAATAAGGACCCTGAAGAATTATTTAAACAAGAGATGCCTCCAAG
ATGTAGCTCTCCTACAGTGGGGCCACCTCCATTGCCACAGAAATCACTGGAAACCAGGGCTCAGAAAAAGCTCTCTTGTAGTCTAGAAGA
CTTGAGAAGTGAATCTGTGGATAAGTGTATGGATGGGAACCAGCCCTTCCCGGTGTTAGAACCCAAGGACAGCCCTTTCTTGGCGGAGCA
CAAATATCCCACTTTACCTGGGAAGCTTTCAGGAGCCACGCCCAATGGAGAGGCTGCCAAATCTCCTCCCACCATCTGCCAGCCTGACGC
CACGGGGAGCAGCCTGCTGAGGCTGAGAGACACAGAAAGTGGCTGGGACGACACTGCTGTGGTCAATGACCTCTCATCCACATCATCGGG
CACTGAATCAGGTCCTCAGTCTCCTCTGACACCAGATGGTAAACGGAATCCCAAAGGCATTAAGAAGTTCTGGGGAAAAATCCGAAGAAC
TCAGTCAGGAAATTTCTACACTGACACGCTGGGGATGGCAGAGTTTCGACGAGGTGGGCTCCGGGCAACCGCAGGGCCAAGACTCTCTAG
GACCAGGGACTCCAAGGGACAGAAAAGTGACGCCAATGCCCCCTTTGCCCAGTGGAGCACAGAGCGTGTGTGTGCATGGCTGGAGGACTT
TGGCCTGGCTCAGTATGTGATCTTTGCCAGGCAGTGGGTATCTTCTGGCCACACCTTATTGACAGCCACCCCTCAGGACATGGAAAAGGA
GCTAGGAATTAAGCACCCACTCCACAGGAAGAAGCTTGTTTTAGCAGTGAAAGCCATCAACACCAAACAGGAGGAGAAGTCTGCACTGCT
AGACCACATTTGGGTGACAAGGTGGCTTGATGATATTGGCTTACCCCAGTACAAAGACCAGTTTCATGAATCTAGAGTTGACAGACGAAT
GCTGCAATACCTAACTGTGAACGATTTACTCTTCTTAAAAGTCACCAGCCAACTACATCATCTCAGCATCAAATGTGCCATTCACGTGCT
GCATGTCAACAAGTTCAACCCCCACTGCCTGCACCGGCGGCCAGCTGATGAGAGTAACCTTTCTCCTTCAGAAGTTGTACAGTGGTCCAA
CCACAGGGTGATGGAGTGGTTACGATCTGTGGACCTGGCAGAGTATGCACCCAATCTTCGAGGGAGTGGAGTCCATGGAGGCCTCATTAT
CCTGGAGCCACGCTTCACTGGGGACACCCTGGCTATGCTTCTCAACATCCCCCCACAAAAGACGCTCCTCAGGCGCCACCTGACCACCAA
GTTCAATGCCTTGATTGGTCCGGAGGCTGAACAGGAGAAGCGAGAGAAAATGGCCTCACCAGCTTACACACCACTGACCACCACAGCCAA
AGTCCGGCCAAGGAAACTAGGATTTTCACACTTCGGAAACATAAGAAAAAAGAAGTTCGATGAATCGACGGACTACATTTGCCCAATGGA
GCCCAGTGACGGTGTCAGTGATAGTCACAGGGTCTACAGTGGCTACCGGGGCCTCAGCCCCCTTGATGCCCCTGAACTGGATGGGCTGGA
CCAGGTGGGACAGATTAGCTGATGCCCTTGTCACCTGCCCTCTGTGCACCCTGAGAGCTCACAGTAACACTGTGTGTGTCACCATATAAC
TGCACCTCACCCCCGCACGTGTGCATGACTCGCAGAGAATATTCCAGCAATTGTGTACCCCTGGGCCAGTCTCTTTGAACCCTGAGGGTG
GCCAGGATCTGGAGCTGCATCTCTAAGGGGCCAGGCTTTGGGGACCATTGCCAAAGGTGGACTCAGGAGGAAAGACACTTAAAGACACTT
TTACATGTCTAGTAATTCTTGATGTTCATCTTCAGCACCAGTGGAAACACATGAACTTCGATGCAGGTCCAGAGACCATGGACACTCCCA
CGAGGCTCAGCTCTCAGGCACCCCCTACACTTCAGTTGAGGGAAAAGCTCAAGTGCCTTAGGCCCGTGGACCACAGTCTTGGCTGAGATC
AAAGGGATGAGCAACAGGGACTTCTGCCACAGTGACAATGGAATTGTGTTGTGCCTTACTTCAGAGGTGGTCTCTTCTTTCTTGTAATAA

>In-frame_ENST00000530044_ENST00000530181_BI669204_DENND5A_chr11_9286507_-_PPFIBP2_chr11_7631521_length(amino acids)=732AA_start in transcript=73_stop in transcript=2271
MSSADWTRRPGWSRTSCRELLSRTSLETQKLDLMTEVSELKLKLVGMEKEQREQEEKQRKAEELLQELRHLKIKVEELENERNQYEWKLK
ATKAEVAQLQEQVALKDAEIERLHSQLSRTAALHSESHTERDQEIQRLKMGMETLLLANEDKDRRIEELTGLLNQYRKVKEIVMVTQGPS
ERTLSINEEEPEGGFSKWNATNKDPEELFKQEMPPRCSSPTVGPPPLPQKSLETRAQKKLSCSLEDLRSESVDKCMDGNQPFPVLEPKDS
PFLAEHKYPTLPGKLSGATPNGEAAKSPPTICQPDATGSSLLRLRDTESGWDDTAVVNDLSSTSSGTESGPQSPLTPDGKRNPKGIKKFW
GKIRRTQSGNFYTDTLGMAEFRRGGLRATAGPRLSRTRDSKGQKSDANAPFAQWSTERVCAWLEDFGLAQYVIFARQWVSSGHTLLTATP
QDMEKELGIKHPLHRKKLVLAVKAINTKQEEKSALLDHIWVTRWLDDIGLPQYKDQFHESRVDRRMLQYLTVNDLLFLKVTSQLHHLSIK
CAIHVLHVNKFNPHCLHRRPADESNLSPSEVVQWSNHRVMEWLRSVDLAEYAPNLRGSGVHGGLIILEPRFTGDTLAMLLNIPPQKTLLR
RHLTTKFNALIGPEAEQEKREKMASPAYTPLTTTAKVRPRKLGFSHFGNIRKKKFDESTDYICPMEPSDGVSDSHRVYSGYRGLSPLDAP

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Fusion Gene PPI Analysis for DENND5A-PPFIBP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DENND5A-PPFIBP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DENND5A-PPFIBP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDENND5AC0543888Epileptic encephalopathy2GENOMICS_ENGLAND
HgeneDENND5AC4310635EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 492CTD_human;GENOMICS_ENGLAND;UNIPROT
TgenePPFIBP2C0033578Prostatic Neoplasms1CTD_human
TgenePPFIBP2C0376358Malignant neoplasm of prostate1CTD_human
TgenePPFIBP2C2931456Prostate cancer, familial1CTD_human
TgenePPFIBP2C4722327PROSTATE CANCER, HEREDITARY, 11CTD_human