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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:DENND5A-SBF2 (FusionGDB2 ID:22259) |
Fusion Gene Summary for DENND5A-SBF2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DENND5A-SBF2 | Fusion gene ID: 22259 | Hgene | Tgene | Gene symbol | DENND5A | SBF2 | Gene ID | 23258 | 81846 |
| Gene name | DENN domain containing 5A | SET binding factor 2 | |
| Synonyms | EIEE49|RAB6IP1 | CMT4B2|DENND7B|MTMR13 | |
| Cytomap | 11p15.4 | 11p15.4 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DENN domain-containing protein 5ADENN/MADD domain containing 5ARAB6 interacting protein 1rab6-interacting protein 1 | myotubularin-related protein 13DENN/MADD domain containing 7Binactive phosphatidylinositol 3-phosphatase 13 | |
| Modification date | 20200313 | 20200328 | |
| UniProtAcc | Q6IQ26 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000328194, ENST00000530044, ENST00000527700, ENST00000526523, | ENST00000256190, ENST00000527019, | |
| Fusion gene scores | * DoF score | 12 X 10 X 5=600 | 21 X 19 X 5=1995 |
| # samples | 14 | 23 | |
| ** MAII score | log2(14/600*10)=-2.09953567355091 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(23/1995*10)=-3.11668298016533 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DENND5A [Title/Abstract] AND SBF2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | DENND5A(9215041)-SBF2(9879943), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across DENND5A (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across SBF2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-D8-A1XT-01A | DENND5A | chr11 | 9215041 | - | SBF2 | chr11 | 9879943 | - |
| ChimerDB4 | BRCA | TCGA-D8-A1XT | DENND5A | chr11 | 9215040 | - | SBF2 | chr11 | 9879943 | - |
| ChimerDB4 | BRCA | TCGA-D8-A1XT-01A | DENND5A | chr11 | 9215041 | - | SBF2 | chr11 | 9879943 | - |
| ChimerDB4 | BRCA | TCGA-D8-A1XT-01A | DENND5A | chr11 | 9215041 | - | SBF2 | chr11 | 9879943 | - |
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Fusion Gene ORF analysis for DENND5A-SBF2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000328194 | ENST00000256190 | DENND5A | chr11 | 9215041 | - | SBF2 | chr11 | 9879943 | - |
| 5CDS-intron | ENST00000328194 | ENST00000527019 | DENND5A | chr11 | 9215041 | - | SBF2 | chr11 | 9879943 | - |
| In-frame | ENST00000530044 | ENST00000256190 | DENND5A | chr11 | 9215041 | - | SBF2 | chr11 | 9879943 | - |
| 5CDS-intron | ENST00000530044 | ENST00000527019 | DENND5A | chr11 | 9215041 | - | SBF2 | chr11 | 9879943 | - |
| intron-3CDS | ENST00000527700 | ENST00000256190 | DENND5A | chr11 | 9215041 | - | SBF2 | chr11 | 9879943 | - |
| intron-intron | ENST00000527700 | ENST00000527019 | DENND5A | chr11 | 9215041 | - | SBF2 | chr11 | 9879943 | - |
| intron-3CDS | ENST00000526523 | ENST00000256190 | DENND5A | chr11 | 9215041 | - | SBF2 | chr11 | 9879943 | - |
| intron-intron | ENST00000526523 | ENST00000527019 | DENND5A | chr11 | 9215041 | - | SBF2 | chr11 | 9879943 | - |
| In-frame | ENST00000328194 | ENST00000256190 | DENND5A | chr11 | 9215040 | - | SBF2 | chr11 | 9879943 | - |
| 5CDS-intron | ENST00000328194 | ENST00000527019 | DENND5A | chr11 | 9215040 | - | SBF2 | chr11 | 9879943 | - |
| In-frame | ENST00000530044 | ENST00000256190 | DENND5A | chr11 | 9215040 | - | SBF2 | chr11 | 9879943 | - |
| 5CDS-intron | ENST00000530044 | ENST00000527019 | DENND5A | chr11 | 9215040 | - | SBF2 | chr11 | 9879943 | - |
| intron-3CDS | ENST00000527700 | ENST00000256190 | DENND5A | chr11 | 9215040 | - | SBF2 | chr11 | 9879943 | - |
| intron-intron | ENST00000527700 | ENST00000527019 | DENND5A | chr11 | 9215040 | - | SBF2 | chr11 | 9879943 | - |
| intron-3CDS | ENST00000526523 | ENST00000256190 | DENND5A | chr11 | 9215040 | - | SBF2 | chr11 | 9879943 | - |
| intron-intron | ENST00000526523 | ENST00000527019 | DENND5A | chr11 | 9215040 | - | SBF2 | chr11 | 9879943 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000328194 | DENND5A | chr11 | 9215041 | - | ENST00000256190 | SBF2 | chr11 | 9879943 | - | 6830 | 1458 | 240 | 5078 | 1612 |
| ENST00000530044 | DENND5A | chr11 | 9215041 | - | ENST00000256190 | SBF2 | chr11 | 9879943 | - | 6527 | 1155 | 18 | 4775 | 1585 |
| ENST00000328194 | DENND5A | chr11 | 9215040 | - | ENST00000256190 | SBF2 | chr11 | 9879943 | - | 6830 | 1458 | 240 | 5078 | 1612 |
| ENST00000530044 | DENND5A | chr11 | 9215040 | - | ENST00000256190 | SBF2 | chr11 | 9879943 | - | 6527 | 1155 | 18 | 4775 | 1585 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000328194 | ENST00000256190 | DENND5A | chr11 | 9215041 | - | SBF2 | chr11 | 9879943 | - | 0.001078037 | 0.998922 |
| ENST00000530044 | ENST00000256190 | DENND5A | chr11 | 9215041 | - | SBF2 | chr11 | 9879943 | - | 0.000671036 | 0.999329 |
| ENST00000328194 | ENST00000256190 | DENND5A | chr11 | 9215040 | - | SBF2 | chr11 | 9879943 | - | 0.001078037 | 0.998922 |
| ENST00000530044 | ENST00000256190 | DENND5A | chr11 | 9215040 | - | SBF2 | chr11 | 9879943 | - | 0.000671036 | 0.999329 |
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Fusion Genomic Features for DENND5A-SBF2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for DENND5A-SBF2 |
| Go to FGviewer for the breakpoints of chr11:9215041-chr11:9879943 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DENND5A | . |
| FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:G3V7Q0, ECO:0000269|PubMed:20937701}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DENND5A | chr11:9215040 | chr11:9879943 | ENST00000328194 | - | 5 | 23 | 3_9 | 379.0 | 1288.0 | Compositional bias | Note=Poly-Gly |
| Hgene | DENND5A | chr11:9215040 | chr11:9879943 | ENST00000530044 | - | 5 | 23 | 3_9 | 379.0 | 1242.0 | Compositional bias | Note=Poly-Gly |
| Hgene | DENND5A | chr11:9215041 | chr11:9879943 | ENST00000328194 | - | 5 | 23 | 3_9 | 379.0 | 1288.0 | Compositional bias | Note=Poly-Gly |
| Hgene | DENND5A | chr11:9215041 | chr11:9879943 | ENST00000530044 | - | 5 | 23 | 3_9 | 379.0 | 1242.0 | Compositional bias | Note=Poly-Gly |
| Hgene | DENND5A | chr11:9215040 | chr11:9879943 | ENST00000328194 | - | 5 | 23 | 57_259 | 379.0 | 1288.0 | Domain | uDENN |
| Hgene | DENND5A | chr11:9215040 | chr11:9879943 | ENST00000530044 | - | 5 | 23 | 57_259 | 379.0 | 1242.0 | Domain | uDENN |
| Hgene | DENND5A | chr11:9215041 | chr11:9879943 | ENST00000328194 | - | 5 | 23 | 57_259 | 379.0 | 1288.0 | Domain | uDENN |
| Hgene | DENND5A | chr11:9215041 | chr11:9879943 | ENST00000530044 | - | 5 | 23 | 57_259 | 379.0 | 1242.0 | Domain | uDENN |
| Tgene | SBF2 | chr11:9215040 | chr11:9879943 | ENST00000256190 | 16 | 40 | 1108_1584 | 643.0 | 1850.0 | Domain | Myotubularin phosphatase | |
| Tgene | SBF2 | chr11:9215040 | chr11:9879943 | ENST00000256190 | 16 | 40 | 1743_1847 | 643.0 | 1850.0 | Domain | PH | |
| Tgene | SBF2 | chr11:9215040 | chr11:9879943 | ENST00000256190 | 16 | 40 | 871_957 | 643.0 | 1850.0 | Domain | GRAM | |
| Tgene | SBF2 | chr11:9215041 | chr11:9879943 | ENST00000256190 | 16 | 40 | 1108_1584 | 643.0 | 1850.0 | Domain | Myotubularin phosphatase | |
| Tgene | SBF2 | chr11:9215041 | chr11:9879943 | ENST00000256190 | 16 | 40 | 1743_1847 | 643.0 | 1850.0 | Domain | PH | |
| Tgene | SBF2 | chr11:9215041 | chr11:9879943 | ENST00000256190 | 16 | 40 | 871_957 | 643.0 | 1850.0 | Domain | GRAM |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DENND5A | chr11:9215040 | chr11:9879943 | ENST00000328194 | - | 5 | 23 | 593_598 | 379.0 | 1288.0 | Compositional bias | Note=Poly-Asp |
| Hgene | DENND5A | chr11:9215040 | chr11:9879943 | ENST00000530044 | - | 5 | 23 | 593_598 | 379.0 | 1242.0 | Compositional bias | Note=Poly-Asp |
| Hgene | DENND5A | chr11:9215041 | chr11:9879943 | ENST00000328194 | - | 5 | 23 | 593_598 | 379.0 | 1288.0 | Compositional bias | Note=Poly-Asp |
| Hgene | DENND5A | chr11:9215041 | chr11:9879943 | ENST00000530044 | - | 5 | 23 | 593_598 | 379.0 | 1242.0 | Compositional bias | Note=Poly-Asp |
| Hgene | DENND5A | chr11:9215040 | chr11:9879943 | ENST00000328194 | - | 5 | 23 | 1134_1282 | 379.0 | 1288.0 | Domain | RUN 2 |
| Hgene | DENND5A | chr11:9215040 | chr11:9879943 | ENST00000328194 | - | 5 | 23 | 278_414 | 379.0 | 1288.0 | Domain | cDENN |
| Hgene | DENND5A | chr11:9215040 | chr11:9879943 | ENST00000328194 | - | 5 | 23 | 416_598 | 379.0 | 1288.0 | Domain | dDENN |
| Hgene | DENND5A | chr11:9215040 | chr11:9879943 | ENST00000328194 | - | 5 | 23 | 787_950 | 379.0 | 1288.0 | Domain | RUN 1 |
| Hgene | DENND5A | chr11:9215040 | chr11:9879943 | ENST00000328194 | - | 5 | 23 | 954_1062 | 379.0 | 1288.0 | Domain | PLAT |
| Hgene | DENND5A | chr11:9215040 | chr11:9879943 | ENST00000530044 | - | 5 | 23 | 1134_1282 | 379.0 | 1242.0 | Domain | RUN 2 |
| Hgene | DENND5A | chr11:9215040 | chr11:9879943 | ENST00000530044 | - | 5 | 23 | 278_414 | 379.0 | 1242.0 | Domain | cDENN |
| Hgene | DENND5A | chr11:9215040 | chr11:9879943 | ENST00000530044 | - | 5 | 23 | 416_598 | 379.0 | 1242.0 | Domain | dDENN |
| Hgene | DENND5A | chr11:9215040 | chr11:9879943 | ENST00000530044 | - | 5 | 23 | 787_950 | 379.0 | 1242.0 | Domain | RUN 1 |
| Hgene | DENND5A | chr11:9215040 | chr11:9879943 | ENST00000530044 | - | 5 | 23 | 954_1062 | 379.0 | 1242.0 | Domain | PLAT |
| Hgene | DENND5A | chr11:9215041 | chr11:9879943 | ENST00000328194 | - | 5 | 23 | 1134_1282 | 379.0 | 1288.0 | Domain | RUN 2 |
| Hgene | DENND5A | chr11:9215041 | chr11:9879943 | ENST00000328194 | - | 5 | 23 | 278_414 | 379.0 | 1288.0 | Domain | cDENN |
| Hgene | DENND5A | chr11:9215041 | chr11:9879943 | ENST00000328194 | - | 5 | 23 | 416_598 | 379.0 | 1288.0 | Domain | dDENN |
| Hgene | DENND5A | chr11:9215041 | chr11:9879943 | ENST00000328194 | - | 5 | 23 | 787_950 | 379.0 | 1288.0 | Domain | RUN 1 |
| Hgene | DENND5A | chr11:9215041 | chr11:9879943 | ENST00000328194 | - | 5 | 23 | 954_1062 | 379.0 | 1288.0 | Domain | PLAT |
| Hgene | DENND5A | chr11:9215041 | chr11:9879943 | ENST00000530044 | - | 5 | 23 | 1134_1282 | 379.0 | 1242.0 | Domain | RUN 2 |
| Hgene | DENND5A | chr11:9215041 | chr11:9879943 | ENST00000530044 | - | 5 | 23 | 278_414 | 379.0 | 1242.0 | Domain | cDENN |
| Hgene | DENND5A | chr11:9215041 | chr11:9879943 | ENST00000530044 | - | 5 | 23 | 416_598 | 379.0 | 1242.0 | Domain | dDENN |
| Hgene | DENND5A | chr11:9215041 | chr11:9879943 | ENST00000530044 | - | 5 | 23 | 787_950 | 379.0 | 1242.0 | Domain | RUN 1 |
| Hgene | DENND5A | chr11:9215041 | chr11:9879943 | ENST00000530044 | - | 5 | 23 | 954_1062 | 379.0 | 1242.0 | Domain | PLAT |
| Tgene | SBF2 | chr11:9215040 | chr11:9879943 | ENST00000256190 | 16 | 40 | 191_324 | 643.0 | 1850.0 | Domain | cDENN | |
| Tgene | SBF2 | chr11:9215040 | chr11:9879943 | ENST00000256190 | 16 | 40 | 326_427 | 643.0 | 1850.0 | Domain | dDENN | |
| Tgene | SBF2 | chr11:9215040 | chr11:9879943 | ENST00000256190 | 16 | 40 | 7_172 | 643.0 | 1850.0 | Domain | uDENN | |
| Tgene | SBF2 | chr11:9215041 | chr11:9879943 | ENST00000256190 | 16 | 40 | 191_324 | 643.0 | 1850.0 | Domain | cDENN | |
| Tgene | SBF2 | chr11:9215041 | chr11:9879943 | ENST00000256190 | 16 | 40 | 326_427 | 643.0 | 1850.0 | Domain | dDENN | |
| Tgene | SBF2 | chr11:9215041 | chr11:9879943 | ENST00000256190 | 16 | 40 | 7_172 | 643.0 | 1850.0 | Domain | uDENN |
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Fusion Gene Sequence for DENND5A-SBF2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000328194_ENST00000256190_TCGA-D8-A1XT-01A_DENND5A_chr11_9215041_-_SBF2_chr11_9879943_length(transcript)=6830nt_BP=1458nt GAGGAGGGTCACGGTGGGGGCTGTCCACGCGCTCTCCGCCCTTCTCCAGGCTCGCTCGGGCCGCGGCGCTCTCGGCTAGCTGCAGCGGCG GCGGCGCGGAGGGGAAGGCATCCAGGATGCGGTGCGGGGCGGCCCGGTGCCCCCCCGCCCCGTCACGGCAGCCGCGGCGGCCGAGGGGAC CGGGCCAGGGCCGGGGGCGGCGGCCCGAGCCGCGGTAGCGGCGGCGGCGGGAGGGGCGGCCTGAGGGCGGACGGGCGGGCGCCCGGGTTG CGGGGGCTCGGTGCCGCTCCGCACTGCCCGGCCGGTCTCGGCCCCGGCGCCATGAGTGGCGGCGGCGGCGGAGGGGGCTCGGCGCCCAGT CGCTTCGCCGACTACTTTGTCATCTGCGGACTGGACACGGAGACCGGGCTGGAGCCGGACGAGCTGTCGGCATTATGCCAGTACATACAG GCTTCTAAAGCCAGGGATGGTGCCAGCCCTTTCATTTCAAGTACGACTGAAGGAGAAAATTTTGAGCAGACACCATTGAGAAGAACATTC AAATCTAAGGTCCTTGCACGATATCCTGAGAACGTAGAATGGAATCCCTTTGACCAAGATGCAGTAGGAATGCTATGTATGCCGAAAGGG CTGGCATTCAAGACCCAGGCTGATCCCAGGGAGCCCCAATTCCATGCCTTTATTATCACAAGGGAGGATGGCTCTCGGACATTTGGGTTT GCCCTCACATTTTATGAAGAGGTGACTAGCAAGCAGATCTGCAGTGCAATGCAGACCCTCTACCACATGCACAATGCTGAGTATGATGTC CTACATGCTCCCCCTGCTGATGACAGAGACCAGAGCAGCATGGAGGATGGTGAAGACACTCCTGTGACCAAACTGCAGCGCTTCAACTCC TATGACATTAGCCGGGACACTCTCTACGTCTCTAAGTGCATCTGCCTCATCACACCCATGTCTTTCATGAAGGCATGTCGGAGCGTGCTG GAGCAACTCCACCAGGCAGTCACTTCACCTCAGCCCCCTCCACTGCCCCTTGAGAGCTACATATACAACGTACTCTACGAGGTGCCGCTC CCACCTCCTGGCCGGTCCTTGAAGTTTTCTGGGGTCTATGGGCCAATAATCTGCCAGAGACCAAGTACCAATGAGCTTCCCCTATTTGAC TTTCCTGTCAAAGAGGTTTTTGAACTGCTCGGGGTGGAGAATGTGTTTCAGCTTTTTACTTGTGCCCTTCTGGAGTTTCAAATCCTGCTC TACTCACAGCATTACCAGAGACTGATGACTGTGGCGGAGACGATTACAGCTCTCATGTTTCCTTTCCAGTGGCAGCATGTCTATGTCCCT ATTCTCCCAGCTTCTCTCCTGCATTTCTTAGATGCTCCTGTTCCATACCTGATGGGTTTGCATTCCAATGGCCTGGATGACCGGTCAAAG CTGGAGCTGCCTCAAGAGAAACTTGCCCCTGGAGTCAGCCAGTTTGCTTACACGTGTGTACAAGACCACCCCATTTGGACAAATCAGCAA TTTTGGGAGACAACCTTTTACAATGCAGTGCAGGAACAGGTTCGCTCCCTTTATCTCTCAGCCAAGGAAGACAATCATGCCCCGCATCTG AAGCAAAAGGATAAGCTTCCTGATGACCATTATCAGGAGAAGACAGCAATGGACCTGGCAGCTGAGCAACTACGCCTTTGGCCTACCCTG AGCAAGTCAACTCAGCAAGAGCTAGTGCAACATGAGGAAAGCACTGTCTTTAGTCAGGCCATTCACTTTGCAAACCTCATGGTGAACCTG CTAGTTCCACTCGACACAAGTAAAAACAAGCTCCTAAGAACATCAGCGCCAGGTGACTGGGAGAGCGGAAGCAACAGCATTGTCACAAAC AGTATTGCAGGAAGTGTAGCTGAGAGCTATGATACAGAGAGTGGGTTTGAAGATTCAGAGAATACTGACATTGCCAATTCTGTTGTGCGG TTCATTACCCGATTTATTGACAAAGTTTGTACAGAGAGTGGAGTTACTCAGGATCACATCAAGAGCCTTCATTGCATGATACCAGGAATT GTAGCTATGCACATTGAGACCCTAGAAGCAGTACATCGAGAAAGCAGAAGACTTCCGCCTATTCAGAAGCCCAAGATTCTTAGACCTGCT CTGCTGCCAGGAGAAGAAATTGTCTGTGAGGGTCTTCGAGTCTTGCTGGATCCTGATGGAAGAGAAGAAGCTACTGGAGGTCTTCTTGGA GGCCCTCAGCTCCTGCCAGCAGAAGGAGCCTTGTTCCTCACCACATACAGAATTCTCTTCAGAGGAACACCCCATGATCAGTTAGTGGGT GAGCAGACAGTTGTGCGGAGCTTTCCCATTGCCTCCATCACCAAGGAGAAGAAGATTACAATGCAGAACCAGCTACAGCAGAACATGCAA GAAGGACTGCAGATCACATCAGCATCTTTTCAGTTGATTAAGGTAGCATTTGATGAAGAAGTCAGTCCAGAAGTAGTAGAGATCTTTAAG AAACAGCTGATGAAGTTCCGTTATCCTCAGTCCATTTTCAGTACCTTTGCTTTTGCTGCTGGACAAACTACCCCACAAATAATTTTACCA AAACAGAAGGAAAAGAACACTTCTTTTCGTACCTTCTCAAAAACAATTGTGAAAGGTGCCAAAAGGGCAGGGAAAATGACAATTGGGCGG CAATATTTACTGAAGAAGAAGACAGGGACAATTGTGGAAGAAAGAGTAAATCGTCCTGGATGGAATGAAGATGATGATGTATCTGTTTCA GATGAGAGTGAGCTCCCCACAAGTACCACCCTGAAGGCCTCCGAGAAGTCTACAATGGAACAGTTGGTGGAAAAAGCTTGTTTCAGAGAC TATCAGCGTTTAGGTTTAGGAACCATAAGTGGCAGCTCTTCCCGTTCAAGACCCGAGTATTTTAGAATTACTGCCTCCAACAGGATGTAT TCACTCTGCCGGAGCTATCCTGGCCTTTTAGTCGTACCTCAAGCTGTACAGGACAGTAGTTTACCAAGAGTAGCTCGCTGCTATCGACAC AATCGCCTGCCTGTTGTATGTTGGAAGAACTCAAGAAGTGGTACTCTGCTCCTCCGATCTGGAGGATTCCATGGGAAGGGAGTCGTTGGT CTTTTCAAATCTCAGAACTCCCCTCAGGCCGCTCCTACCTCCTCTTTAGAATCTTCCAGTAGCATAGAACAAGAGAAATACTTGCAAGCC TTACTGAATGCTGTTTCTGTCCATCAGAAACTCAGAGGCAACAGCACTCTTACTGTCAGGCCAGCCTTTGCTCTATCTCCAGGTGTGTGG GCAAGTCTTCGCTCTAGCACTCGCTTGATCAGCTCTCCAACATCCTTCATTGATGTTGGCGCCCGGCTGGCAGGCAAGGATCACTCGGCC TCCTTCAGTAACAGCAGCTACCTACAAAACCAGCTCTTGAAACGGCAAGCAGCCCTTTACATATTTGGTGAAAAGTCGCAACTAAGGAAC TTCAAGGTAGAATTTGCTTTAAATTGTGAGTTTGTTCCTGTTGAATTTCATGAAATCCGGCAAGTGAAAGCCAGTTTTAAGAAGCTGATG AGGGCTTGTATCCCAAGCACCATCCCTACTGACTCAGAAGTGACCTTCCTGAAAGCGCTGGGAGATTCTGAGTGGTTCCCACAGCTTCAC AGGATAATGCAGCTGGCTGTGGTTGTATCAGAAGTACTTGAGAATGGTTCCTCAGTTTTGGTCTGTTTGGAGGAAGGCTGGGACATCACT GCACAAGTGACATCCCTGGTTCAGTTACTCAGTGATCCCTTTTATAGGACACTTGAAGGCTTCCAGATGTTGGTTGAAAAAGAGTGGCTC TCTTTTGGTCACAAATTCAGTCAGAGGAGCAGCTTGACCCTCAACTGTCAGGGGAGTGGTTTTGCTCCAGTCTTCTTACAGTTCTTAGAC TGTGTACACCAGGTTCACAACCAGTATCCAACTGAGTTTGAATTCAATCTCTATTACTTAAAGTTCTTGGCTTTCCACTATGTGTCTAAT CGCTTTAAAACATTTCTCCTGGATTCAGACTATGAAAGATTAGAGCACGGAACTTTATTTGATGATAAAGGAGAAAAGCATGCCAAAAAA GGAGTCTGTATTTGGGAATGTATTGACAGAATGCACAAGAGGAGTCCCATTTTCTTTAATTATTTATATTCACCATTGGAAATAGAGGCT CTAAAGCCCAATGTAAACGTCTCTAGCCTCAAGAAGTGGGATTACTACATAGAAGAGACCCTGTCCACAGGCCCTTCCTATGACTGGATG ATGCTAACCCCCAAGCACTTCCCCTCCGAAGACTCTGACCTGGCTGGAGAAGCTGGGCCACGGAGCCAGAGGAGAACAGTGTGGCCATGC TATGATGATGTCAGCTGTACTCAGCCTGATGCTCTCACCAGCCTTTTCAGTGAAATTGAAAAATTGGAGCACAAATTGAACCAAGCCCCT GAGAAGTGGCAGCAGCTGTGGGAAAGGGTAACCGTGGACCTTAAAGAAGAACCAAGAACAGATCGCTCCCAAAGACACCTGTCGAGATCC CCAGGAATTGTGTCTACCAACCTACCTTCCTATCAGAAGAGGTCTCTGCTACATCTCCCAGACAGCAGCATGGGGGAGGAACAGAATTCC AGCATCTCCCCATCCAATGGAGTGGAGCGAAGAGCAGCCACGCTCTATAGCCAGTATACATCCAAGAATGATGAAAACAGGTCCTTTGAG GGAACACTTTATAAAAGAGGGGCTTTGCTGAAAGGTTGGAAGCCCCGTTGGTTTGTTTTGGATGTAACAAAACATCAGCTGCGCTACTAT GACTCAGGTGAGGACACAAGCTGTAAAGGCCACATTGATCTGGCTGAAGTAGAAATGGTCATCCCTGCTGGCCCCAGCATGGGAGCCCCA AAGCACACAAGTGACAAGGCTTTCTTTGATCTCAAGACCAGCAAACGTGTGTATAACTTCTGCGCCCAGGATGGACAGAGTGCCCAGCAA TGGATGGACAAGATCCAGAGTTGTATCTCTGATGCCTGATGCCCATGGTCAACCCACGCAGAAGAAACAGAAGAACTCATGCTGCCAGAT AGATAGAAAAAGAAGCATGGATCCTTGAGGAGCTGACAACAAGTTATCCCAGGGCCTGAGGTTCTCCTGCCCAGTCCCCTCTTGCAGGGG TTGCTATATCTACTTAACCTGAATAGGTGTTTCACACAGGTCTGGTCAACAGCCCCATGCACTCCCTGTATCTTGCACTAAATTTTTCTA ACAGGGTCTTAGTGGTTAATGATCAGAAGATGTCTCCTGAGCCAACTGTGAACCTCACCCAGGCAAAATGGCTACCACCTACTTGGGTCC TTCTTCATGAAAGCTATAGATCCTTTTTTGTTCTCTGAGGTCATAATTTCCTCGGAGACCTGTTTAACAAGCAAAAATCAAAACCCTCCA AGATTGTCTCATATTCTACCTGGACTAGGTTTCCTATGAGAGACATCTACTTGTAATGCCTGACCTTTGAGATGCTCAGTTCTCTGGTGC TGCCAAAAGATGCTTCCATGGTCCGTGCTCTGCCAGTGGGGTTCACAACAAGAGACGTCATTGTTCAGTAGCAGGCAAAGAGGGAGCACA CAGCATTATTCTGATGGAAAAAGATTATCCAGGGAATGGTACAACAATGACCAGCCCAATGCAGGAAAACACTACTTCCAAAACACTGAA TTCTCTAGACCAGAGGTGCTCTGAGGATCCAGGGCCTTGTGTTCTTATGTATCTTCTGCTTCCTGACAGCTTCTTTTTCAAAATAACATG CAAAAAAAGCTGAATGCACTAACTCACAAAACAAACACTTGCACTGAATTCCCAATGAAGTGAAGATGTTGGAAAGACAGAGGCCAGCTA TTTAGGACCATACGCACCTGTGACAAGGGCTGTGTTGACCACAGTCACACTGTGGCATGACTGGATACCCAAACTACACTTCTACACATG AAAAGTAAGAACTGTCTTTAGATTTTCTTTACTTTGATAACTTGTGATTGTTTAGCTTAAGACCCAAGAAATGCTGTTTGCTCATGGTAA ACAGAAACAGCATCTTCGCTACAACCACTGACACCAGCTGGCGTCATAGGTAGCTAGATCATTGCATTTGTTTTGAAATGTTAATATGTT AAATACTAAACTAATATTTCAAAAATGTGTATATATGATTTCTATATCCTTGTTTTTCAGATAGCCTGCTTATAATTTAATATAAATTAA CTGATGCATTCATAAGATTTCAATAATGAAATGGTTCCCTTTTAAAAAATAAAAATACTTTGTAGATTAAAAATAAATCAGAATTTCAAA TTTAAAATTGTCCACACACTAGGAAATAGAACTGTGTTAATATATAAGAAATCTGGGGATAATTAAGAATGAAGGACTTTTCTATCATTT CCATTTTATAAATTGCCACCTGTGAAAATGGTTTTTGCACATTATTTGTATTTTTCTTTGTATATGAAATAATTTTTTGTACTTTGTAAA ATATGGAGCCCATTGTACCTTCAGCTATTTGAGACTATACACAGTGCTTCTTTTGTAACTGGATTACTTTAACTTTCGTGAAGGCATTAC ATTGCCTCACATTCACTAACCACCTTGAATTAAATTTATTTCTTAAGAAAAAGCATCCCTCATTTACTGTGAACTAAAGTTCATTCTGTA >In-frame_ENST00000328194_ENST00000256190_TCGA-D8-A1XT-01A_DENND5A_chr11_9215041_-_SBF2_chr11_9879943_length(amino acids)=1612AA_start in transcript=240_stop in transcript=5078 MRADGRAPGLRGLGAAPHCPAGLGPGAMSGGGGGGGSAPSRFADYFVICGLDTETGLEPDELSALCQYIQASKARDGASPFISSTTEGEN FEQTPLRRTFKSKVLARYPENVEWNPFDQDAVGMLCMPKGLAFKTQADPREPQFHAFIITREDGSRTFGFALTFYEEVTSKQICSAMQTL YHMHNAEYDVLHAPPADDRDQSSMEDGEDTPVTKLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQPPPLPLESY IYNVLYEVPLPPPGRSLKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMF PFQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDRSKLELPQEKLAPGVSQFAYTCVQDHPIWTNQQFWETTFYNAVQEQVRSLYLS AKEDNHAPHLKQKDKLPDDHYQEKTAMDLAAEQLRLWPTLSKSTQQELVQHEESTVFSQAIHFANLMVNLLVPLDTSKNKLLRTSAPGDW ESGSNSIVTNSIAGSVAESYDTESGFEDSENTDIANSVVRFITRFIDKVCTESGVTQDHIKSLHCMIPGIVAMHIETLEAVHRESRRLPP IQKPKILRPALLPGEEIVCEGLRVLLDPDGREEATGGLLGGPQLLPAEGALFLTTYRILFRGTPHDQLVGEQTVVRSFPIASITKEKKIT MQNQLQQNMQEGLQITSASFQLIKVAFDEEVSPEVVEIFKKQLMKFRYPQSIFSTFAFAAGQTTPQIILPKQKEKNTSFRTFSKTIVKGA KRAGKMTIGRQYLLKKKTGTIVEERVNRPGWNEDDDVSVSDESELPTSTTLKASEKSTMEQLVEKACFRDYQRLGLGTISGSSSRSRPEY FRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRSGGFHGKGVVGLFKSQNSPQAAPTSSLESSS SIEQEKYLQALLNAVSVHQKLRGNSTLTVRPAFALSPGVWASLRSSTRLISSPTSFIDVGARLAGKDHSASFSNSSYLQNQLLKRQAALY IFGEKSQLRNFKVEFALNCEFVPVEFHEIRQVKASFKKLMRACIPSTIPTDSEVTFLKALGDSEWFPQLHRIMQLAVVVSEVLENGSSVL VCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQMLVEKEWLSFGHKFSQRSSLTLNCQGSGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYL KFLAFHYVSNRFKTFLLDSDYERLEHGTLFDDKGEKHAKKGVCIWECIDRMHKRSPIFFNYLYSPLEIEALKPNVNVSSLKKWDYYIEET LSTGPSYDWMMLTPKHFPSEDSDLAGEAGPRSQRRTVWPCYDDVSCTQPDALTSLFSEIEKLEHKLNQAPEKWQQLWERVTVDLKEEPRT DRSQRHLSRSPGIVSTNLPSYQKRSLLHLPDSSMGEEQNSSISPSNGVERRAATLYSQYTSKNDENRSFEGTLYKRGALLKGWKPRWFVL -------------------------------------------------------------- >In-frame_ENST00000530044_ENST00000256190_TCGA-D8-A1XT-01A_DENND5A_chr11_9215041_-_SBF2_chr11_9879943_length(transcript)=6527nt_BP=1155nt GGTCTCGGCCCCGGCGCCATGAGTGGCGGCGGCGGCGGAGGGGGCTCGGCGCCCAGTCGCTTCGCCGACTACTTTGTCATCTGCGGACTG GACACGGAGACCGGGCTGGAGCCGGACGAGCTGTCGGCATTATGCCAGTACATACAGGCTTCTAAAGCCAGGGATGGTGCCAGCCCTTTC ATTTCAAGTACGACTGAAGGAGAAAATTTTGAGCAGACACCATTGAGAAGAACATTCAAATCTAAGGTCCTTGCACGATATCCTGAGAAC GTAGAATGGAATCCCTTTGACCAAGATGCAGTAGGAATGCTATGTATGCCGAAAGGGCTGGCATTCAAGACCCAGGCTGATCCCAGGGAG CCCCAATTCCATGCCTTTATTATCACAAGGGAGGATGGCTCTCGGACATTTGGGTTTGCCCTCACATTTTATGAAGAGGTGACTAGCAAG CAGATCTGCAGTGCAATGCAGACCCTCTACCACATGCACAATGCTGAGTATGATGTCCTACATGCTCCCCCTGCTGATGACAGAGACCAG AGCAGCATGGAGGATGGTGAAGACACTCCTGTGACCAAACTGCAGCGCTTCAACTCCTATGACATTAGCCGGGACACTCTCTACGTCTCT AAGTGCATCTGCCTCATCACACCCATGTCTTTCATGAAGGCATGTCGGAGCGTGCTGGAGCAACTCCACCAGGCAGTCACTTCACCTCAG CCCCCTCCACTGCCCCTTGAGAGCTACATATACAACGTACTCTACGAGGTGCCGCTCCCACCTCCTGGCCGGTCCTTGAAGTTTTCTGGG GTCTATGGGCCAATAATCTGCCAGAGACCAAGTACCAATGAGCTTCCCCTATTTGACTTTCCTGTCAAAGAGGTTTTTGAACTGCTCGGG GTGGAGAATGTGTTTCAGCTTTTTACTTGTGCCCTTCTGGAGTTTCAAATCCTGCTCTACTCACAGCATTACCAGAGACTGATGACTGTG GCGGAGACGATTACAGCTCTCATGTTTCCTTTCCAGTGGCAGCATGTCTATGTCCCTATTCTCCCAGCTTCTCTCCTGCATTTCTTAGAT GCTCCTGTTCCATACCTGATGGGTTTGCATTCCAATGGCCTGGATGACCGGTCAAAGCTGGAGCTGCCTCAAGAGAAACTTGCCCCTGGA GTCAGCCAGTTTGCTTACACGTGTGTACAAGACCACCCCATTTGGACAAATCAGCAATTTTGGGAGACAACCTTTTACAATGCAGTGCAG GAACAGGTTCGCTCCCTTTATCTCTCAGCCAAGGAAGACAATCATGCCCCGCATCTGAAGCAAAAGGATAAGCTTCCTGATGACCATTAT CAGGAGAAGACAGCAATGGACCTGGCAGCTGAGCAACTACGCCTTTGGCCTACCCTGAGCAAGTCAACTCAGCAAGAGCTAGTGCAACAT GAGGAAAGCACTGTCTTTAGTCAGGCCATTCACTTTGCAAACCTCATGGTGAACCTGCTAGTTCCACTCGACACAAGTAAAAACAAGCTC CTAAGAACATCAGCGCCAGGTGACTGGGAGAGCGGAAGCAACAGCATTGTCACAAACAGTATTGCAGGAAGTGTAGCTGAGAGCTATGAT ACAGAGAGTGGGTTTGAAGATTCAGAGAATACTGACATTGCCAATTCTGTTGTGCGGTTCATTACCCGATTTATTGACAAAGTTTGTACA GAGAGTGGAGTTACTCAGGATCACATCAAGAGCCTTCATTGCATGATACCAGGAATTGTAGCTATGCACATTGAGACCCTAGAAGCAGTA CATCGAGAAAGCAGAAGACTTCCGCCTATTCAGAAGCCCAAGATTCTTAGACCTGCTCTGCTGCCAGGAGAAGAAATTGTCTGTGAGGGT CTTCGAGTCTTGCTGGATCCTGATGGAAGAGAAGAAGCTACTGGAGGTCTTCTTGGAGGCCCTCAGCTCCTGCCAGCAGAAGGAGCCTTG TTCCTCACCACATACAGAATTCTCTTCAGAGGAACACCCCATGATCAGTTAGTGGGTGAGCAGACAGTTGTGCGGAGCTTTCCCATTGCC TCCATCACCAAGGAGAAGAAGATTACAATGCAGAACCAGCTACAGCAGAACATGCAAGAAGGACTGCAGATCACATCAGCATCTTTTCAG TTGATTAAGGTAGCATTTGATGAAGAAGTCAGTCCAGAAGTAGTAGAGATCTTTAAGAAACAGCTGATGAAGTTCCGTTATCCTCAGTCC ATTTTCAGTACCTTTGCTTTTGCTGCTGGACAAACTACCCCACAAATAATTTTACCAAAACAGAAGGAAAAGAACACTTCTTTTCGTACC TTCTCAAAAACAATTGTGAAAGGTGCCAAAAGGGCAGGGAAAATGACAATTGGGCGGCAATATTTACTGAAGAAGAAGACAGGGACAATT GTGGAAGAAAGAGTAAATCGTCCTGGATGGAATGAAGATGATGATGTATCTGTTTCAGATGAGAGTGAGCTCCCCACAAGTACCACCCTG AAGGCCTCCGAGAAGTCTACAATGGAACAGTTGGTGGAAAAAGCTTGTTTCAGAGACTATCAGCGTTTAGGTTTAGGAACCATAAGTGGC AGCTCTTCCCGTTCAAGACCCGAGTATTTTAGAATTACTGCCTCCAACAGGATGTATTCACTCTGCCGGAGCTATCCTGGCCTTTTAGTC GTACCTCAAGCTGTACAGGACAGTAGTTTACCAAGAGTAGCTCGCTGCTATCGACACAATCGCCTGCCTGTTGTATGTTGGAAGAACTCA AGAAGTGGTACTCTGCTCCTCCGATCTGGAGGATTCCATGGGAAGGGAGTCGTTGGTCTTTTCAAATCTCAGAACTCCCCTCAGGCCGCT CCTACCTCCTCTTTAGAATCTTCCAGTAGCATAGAACAAGAGAAATACTTGCAAGCCTTACTGAATGCTGTTTCTGTCCATCAGAAACTC AGAGGCAACAGCACTCTTACTGTCAGGCCAGCCTTTGCTCTATCTCCAGGTGTGTGGGCAAGTCTTCGCTCTAGCACTCGCTTGATCAGC TCTCCAACATCCTTCATTGATGTTGGCGCCCGGCTGGCAGGCAAGGATCACTCGGCCTCCTTCAGTAACAGCAGCTACCTACAAAACCAG CTCTTGAAACGGCAAGCAGCCCTTTACATATTTGGTGAAAAGTCGCAACTAAGGAACTTCAAGGTAGAATTTGCTTTAAATTGTGAGTTT GTTCCTGTTGAATTTCATGAAATCCGGCAAGTGAAAGCCAGTTTTAAGAAGCTGATGAGGGCTTGTATCCCAAGCACCATCCCTACTGAC TCAGAAGTGACCTTCCTGAAAGCGCTGGGAGATTCTGAGTGGTTCCCACAGCTTCACAGGATAATGCAGCTGGCTGTGGTTGTATCAGAA GTACTTGAGAATGGTTCCTCAGTTTTGGTCTGTTTGGAGGAAGGCTGGGACATCACTGCACAAGTGACATCCCTGGTTCAGTTACTCAGT GATCCCTTTTATAGGACACTTGAAGGCTTCCAGATGTTGGTTGAAAAAGAGTGGCTCTCTTTTGGTCACAAATTCAGTCAGAGGAGCAGC TTGACCCTCAACTGTCAGGGGAGTGGTTTTGCTCCAGTCTTCTTACAGTTCTTAGACTGTGTACACCAGGTTCACAACCAGTATCCAACT GAGTTTGAATTCAATCTCTATTACTTAAAGTTCTTGGCTTTCCACTATGTGTCTAATCGCTTTAAAACATTTCTCCTGGATTCAGACTAT GAAAGATTAGAGCACGGAACTTTATTTGATGATAAAGGAGAAAAGCATGCCAAAAAAGGAGTCTGTATTTGGGAATGTATTGACAGAATG CACAAGAGGAGTCCCATTTTCTTTAATTATTTATATTCACCATTGGAAATAGAGGCTCTAAAGCCCAATGTAAACGTCTCTAGCCTCAAG AAGTGGGATTACTACATAGAAGAGACCCTGTCCACAGGCCCTTCCTATGACTGGATGATGCTAACCCCCAAGCACTTCCCCTCCGAAGAC TCTGACCTGGCTGGAGAAGCTGGGCCACGGAGCCAGAGGAGAACAGTGTGGCCATGCTATGATGATGTCAGCTGTACTCAGCCTGATGCT CTCACCAGCCTTTTCAGTGAAATTGAAAAATTGGAGCACAAATTGAACCAAGCCCCTGAGAAGTGGCAGCAGCTGTGGGAAAGGGTAACC GTGGACCTTAAAGAAGAACCAAGAACAGATCGCTCCCAAAGACACCTGTCGAGATCCCCAGGAATTGTGTCTACCAACCTACCTTCCTAT CAGAAGAGGTCTCTGCTACATCTCCCAGACAGCAGCATGGGGGAGGAACAGAATTCCAGCATCTCCCCATCCAATGGAGTGGAGCGAAGA GCAGCCACGCTCTATAGCCAGTATACATCCAAGAATGATGAAAACAGGTCCTTTGAGGGAACACTTTATAAAAGAGGGGCTTTGCTGAAA GGTTGGAAGCCCCGTTGGTTTGTTTTGGATGTAACAAAACATCAGCTGCGCTACTATGACTCAGGTGAGGACACAAGCTGTAAAGGCCAC ATTGATCTGGCTGAAGTAGAAATGGTCATCCCTGCTGGCCCCAGCATGGGAGCCCCAAAGCACACAAGTGACAAGGCTTTCTTTGATCTC AAGACCAGCAAACGTGTGTATAACTTCTGCGCCCAGGATGGACAGAGTGCCCAGCAATGGATGGACAAGATCCAGAGTTGTATCTCTGAT GCCTGATGCCCATGGTCAACCCACGCAGAAGAAACAGAAGAACTCATGCTGCCAGATAGATAGAAAAAGAAGCATGGATCCTTGAGGAGC TGACAACAAGTTATCCCAGGGCCTGAGGTTCTCCTGCCCAGTCCCCTCTTGCAGGGGTTGCTATATCTACTTAACCTGAATAGGTGTTTC ACACAGGTCTGGTCAACAGCCCCATGCACTCCCTGTATCTTGCACTAAATTTTTCTAACAGGGTCTTAGTGGTTAATGATCAGAAGATGT CTCCTGAGCCAACTGTGAACCTCACCCAGGCAAAATGGCTACCACCTACTTGGGTCCTTCTTCATGAAAGCTATAGATCCTTTTTTGTTC TCTGAGGTCATAATTTCCTCGGAGACCTGTTTAACAAGCAAAAATCAAAACCCTCCAAGATTGTCTCATATTCTACCTGGACTAGGTTTC CTATGAGAGACATCTACTTGTAATGCCTGACCTTTGAGATGCTCAGTTCTCTGGTGCTGCCAAAAGATGCTTCCATGGTCCGTGCTCTGC CAGTGGGGTTCACAACAAGAGACGTCATTGTTCAGTAGCAGGCAAAGAGGGAGCACACAGCATTATTCTGATGGAAAAAGATTATCCAGG GAATGGTACAACAATGACCAGCCCAATGCAGGAAAACACTACTTCCAAAACACTGAATTCTCTAGACCAGAGGTGCTCTGAGGATCCAGG GCCTTGTGTTCTTATGTATCTTCTGCTTCCTGACAGCTTCTTTTTCAAAATAACATGCAAAAAAAGCTGAATGCACTAACTCACAAAACA AACACTTGCACTGAATTCCCAATGAAGTGAAGATGTTGGAAAGACAGAGGCCAGCTATTTAGGACCATACGCACCTGTGACAAGGGCTGT GTTGACCACAGTCACACTGTGGCATGACTGGATACCCAAACTACACTTCTACACATGAAAAGTAAGAACTGTCTTTAGATTTTCTTTACT TTGATAACTTGTGATTGTTTAGCTTAAGACCCAAGAAATGCTGTTTGCTCATGGTAAACAGAAACAGCATCTTCGCTACAACCACTGACA CCAGCTGGCGTCATAGGTAGCTAGATCATTGCATTTGTTTTGAAATGTTAATATGTTAAATACTAAACTAATATTTCAAAAATGTGTATA TATGATTTCTATATCCTTGTTTTTCAGATAGCCTGCTTATAATTTAATATAAATTAACTGATGCATTCATAAGATTTCAATAATGAAATG GTTCCCTTTTAAAAAATAAAAATACTTTGTAGATTAAAAATAAATCAGAATTTCAAATTTAAAATTGTCCACACACTAGGAAATAGAACT GTGTTAATATATAAGAAATCTGGGGATAATTAAGAATGAAGGACTTTTCTATCATTTCCATTTTATAAATTGCCACCTGTGAAAATGGTT TTTGCACATTATTTGTATTTTTCTTTGTATATGAAATAATTTTTTGTACTTTGTAAAATATGGAGCCCATTGTACCTTCAGCTATTTGAG ACTATACACAGTGCTTCTTTTGTAACTGGATTACTTTAACTTTCGTGAAGGCATTACATTGCCTCACATTCACTAACCACCTTGAATTAA ATTTATTTCTTAAGAAAAAGCATCCCTCATTTACTGTGAACTAAAGTTCATTCTGTAGTGCACAGCATTCAGGAGGGTAACACTCAGGAT >In-frame_ENST00000530044_ENST00000256190_TCGA-D8-A1XT-01A_DENND5A_chr11_9215041_-_SBF2_chr11_9879943_length(amino acids)=1585AA_start in transcript=18_stop in transcript=4775 MSGGGGGGGSAPSRFADYFVICGLDTETGLEPDELSALCQYIQASKARDGASPFISSTTEGENFEQTPLRRTFKSKVLARYPENVEWNPF DQDAVGMLCMPKGLAFKTQADPREPQFHAFIITREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPPADDRDQSSMEDG EDTPVTKLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQPPPLPLESYIYNVLYEVPLPPPGRSLKFSGVYGPII CQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYL MGLHSNGLDDRSKLELPQEKLAPGVSQFAYTCVQDHPIWTNQQFWETTFYNAVQEQVRSLYLSAKEDNHAPHLKQKDKLPDDHYQEKTAM DLAAEQLRLWPTLSKSTQQELVQHEESTVFSQAIHFANLMVNLLVPLDTSKNKLLRTSAPGDWESGSNSIVTNSIAGSVAESYDTESGFE DSENTDIANSVVRFITRFIDKVCTESGVTQDHIKSLHCMIPGIVAMHIETLEAVHRESRRLPPIQKPKILRPALLPGEEIVCEGLRVLLD PDGREEATGGLLGGPQLLPAEGALFLTTYRILFRGTPHDQLVGEQTVVRSFPIASITKEKKITMQNQLQQNMQEGLQITSASFQLIKVAF DEEVSPEVVEIFKKQLMKFRYPQSIFSTFAFAAGQTTPQIILPKQKEKNTSFRTFSKTIVKGAKRAGKMTIGRQYLLKKKTGTIVEERVN RPGWNEDDDVSVSDESELPTSTTLKASEKSTMEQLVEKACFRDYQRLGLGTISGSSSRSRPEYFRITASNRMYSLCRSYPGLLVVPQAVQ DSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRSGGFHGKGVVGLFKSQNSPQAAPTSSLESSSSIEQEKYLQALLNAVSVHQKLRGNSTL TVRPAFALSPGVWASLRSSTRLISSPTSFIDVGARLAGKDHSASFSNSSYLQNQLLKRQAALYIFGEKSQLRNFKVEFALNCEFVPVEFH EIRQVKASFKKLMRACIPSTIPTDSEVTFLKALGDSEWFPQLHRIMQLAVVVSEVLENGSSVLVCLEEGWDITAQVTSLVQLLSDPFYRT LEGFQMLVEKEWLSFGHKFSQRSSLTLNCQGSGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYERLEHG TLFDDKGEKHAKKGVCIWECIDRMHKRSPIFFNYLYSPLEIEALKPNVNVSSLKKWDYYIEETLSTGPSYDWMMLTPKHFPSEDSDLAGE AGPRSQRRTVWPCYDDVSCTQPDALTSLFSEIEKLEHKLNQAPEKWQQLWERVTVDLKEEPRTDRSQRHLSRSPGIVSTNLPSYQKRSLL HLPDSSMGEEQNSSISPSNGVERRAATLYSQYTSKNDENRSFEGTLYKRGALLKGWKPRWFVLDVTKHQLRYYDSGEDTSCKGHIDLAEV -------------------------------------------------------------- >In-frame_ENST00000328194_ENST00000256190_TCGA-D8-A1XT_DENND5A_chr11_9215040_-_SBF2_chr11_9879943_length(transcript)=6830nt_BP=1458nt GAGGAGGGTCACGGTGGGGGCTGTCCACGCGCTCTCCGCCCTTCTCCAGGCTCGCTCGGGCCGCGGCGCTCTCGGCTAGCTGCAGCGGCG GCGGCGCGGAGGGGAAGGCATCCAGGATGCGGTGCGGGGCGGCCCGGTGCCCCCCCGCCCCGTCACGGCAGCCGCGGCGGCCGAGGGGAC CGGGCCAGGGCCGGGGGCGGCGGCCCGAGCCGCGGTAGCGGCGGCGGCGGGAGGGGCGGCCTGAGGGCGGACGGGCGGGCGCCCGGGTTG CGGGGGCTCGGTGCCGCTCCGCACTGCCCGGCCGGTCTCGGCCCCGGCGCCATGAGTGGCGGCGGCGGCGGAGGGGGCTCGGCGCCCAGT CGCTTCGCCGACTACTTTGTCATCTGCGGACTGGACACGGAGACCGGGCTGGAGCCGGACGAGCTGTCGGCATTATGCCAGTACATACAG GCTTCTAAAGCCAGGGATGGTGCCAGCCCTTTCATTTCAAGTACGACTGAAGGAGAAAATTTTGAGCAGACACCATTGAGAAGAACATTC AAATCTAAGGTCCTTGCACGATATCCTGAGAACGTAGAATGGAATCCCTTTGACCAAGATGCAGTAGGAATGCTATGTATGCCGAAAGGG CTGGCATTCAAGACCCAGGCTGATCCCAGGGAGCCCCAATTCCATGCCTTTATTATCACAAGGGAGGATGGCTCTCGGACATTTGGGTTT GCCCTCACATTTTATGAAGAGGTGACTAGCAAGCAGATCTGCAGTGCAATGCAGACCCTCTACCACATGCACAATGCTGAGTATGATGTC CTACATGCTCCCCCTGCTGATGACAGAGACCAGAGCAGCATGGAGGATGGTGAAGACACTCCTGTGACCAAACTGCAGCGCTTCAACTCC TATGACATTAGCCGGGACACTCTCTACGTCTCTAAGTGCATCTGCCTCATCACACCCATGTCTTTCATGAAGGCATGTCGGAGCGTGCTG GAGCAACTCCACCAGGCAGTCACTTCACCTCAGCCCCCTCCACTGCCCCTTGAGAGCTACATATACAACGTACTCTACGAGGTGCCGCTC CCACCTCCTGGCCGGTCCTTGAAGTTTTCTGGGGTCTATGGGCCAATAATCTGCCAGAGACCAAGTACCAATGAGCTTCCCCTATTTGAC TTTCCTGTCAAAGAGGTTTTTGAACTGCTCGGGGTGGAGAATGTGTTTCAGCTTTTTACTTGTGCCCTTCTGGAGTTTCAAATCCTGCTC TACTCACAGCATTACCAGAGACTGATGACTGTGGCGGAGACGATTACAGCTCTCATGTTTCCTTTCCAGTGGCAGCATGTCTATGTCCCT ATTCTCCCAGCTTCTCTCCTGCATTTCTTAGATGCTCCTGTTCCATACCTGATGGGTTTGCATTCCAATGGCCTGGATGACCGGTCAAAG CTGGAGCTGCCTCAAGAGAAACTTGCCCCTGGAGTCAGCCAGTTTGCTTACACGTGTGTACAAGACCACCCCATTTGGACAAATCAGCAA TTTTGGGAGACAACCTTTTACAATGCAGTGCAGGAACAGGTTCGCTCCCTTTATCTCTCAGCCAAGGAAGACAATCATGCCCCGCATCTG AAGCAAAAGGATAAGCTTCCTGATGACCATTATCAGGAGAAGACAGCAATGGACCTGGCAGCTGAGCAACTACGCCTTTGGCCTACCCTG AGCAAGTCAACTCAGCAAGAGCTAGTGCAACATGAGGAAAGCACTGTCTTTAGTCAGGCCATTCACTTTGCAAACCTCATGGTGAACCTG CTAGTTCCACTCGACACAAGTAAAAACAAGCTCCTAAGAACATCAGCGCCAGGTGACTGGGAGAGCGGAAGCAACAGCATTGTCACAAAC AGTATTGCAGGAAGTGTAGCTGAGAGCTATGATACAGAGAGTGGGTTTGAAGATTCAGAGAATACTGACATTGCCAATTCTGTTGTGCGG TTCATTACCCGATTTATTGACAAAGTTTGTACAGAGAGTGGAGTTACTCAGGATCACATCAAGAGCCTTCATTGCATGATACCAGGAATT GTAGCTATGCACATTGAGACCCTAGAAGCAGTACATCGAGAAAGCAGAAGACTTCCGCCTATTCAGAAGCCCAAGATTCTTAGACCTGCT CTGCTGCCAGGAGAAGAAATTGTCTGTGAGGGTCTTCGAGTCTTGCTGGATCCTGATGGAAGAGAAGAAGCTACTGGAGGTCTTCTTGGA GGCCCTCAGCTCCTGCCAGCAGAAGGAGCCTTGTTCCTCACCACATACAGAATTCTCTTCAGAGGAACACCCCATGATCAGTTAGTGGGT GAGCAGACAGTTGTGCGGAGCTTTCCCATTGCCTCCATCACCAAGGAGAAGAAGATTACAATGCAGAACCAGCTACAGCAGAACATGCAA GAAGGACTGCAGATCACATCAGCATCTTTTCAGTTGATTAAGGTAGCATTTGATGAAGAAGTCAGTCCAGAAGTAGTAGAGATCTTTAAG AAACAGCTGATGAAGTTCCGTTATCCTCAGTCCATTTTCAGTACCTTTGCTTTTGCTGCTGGACAAACTACCCCACAAATAATTTTACCA AAACAGAAGGAAAAGAACACTTCTTTTCGTACCTTCTCAAAAACAATTGTGAAAGGTGCCAAAAGGGCAGGGAAAATGACAATTGGGCGG CAATATTTACTGAAGAAGAAGACAGGGACAATTGTGGAAGAAAGAGTAAATCGTCCTGGATGGAATGAAGATGATGATGTATCTGTTTCA GATGAGAGTGAGCTCCCCACAAGTACCACCCTGAAGGCCTCCGAGAAGTCTACAATGGAACAGTTGGTGGAAAAAGCTTGTTTCAGAGAC TATCAGCGTTTAGGTTTAGGAACCATAAGTGGCAGCTCTTCCCGTTCAAGACCCGAGTATTTTAGAATTACTGCCTCCAACAGGATGTAT TCACTCTGCCGGAGCTATCCTGGCCTTTTAGTCGTACCTCAAGCTGTACAGGACAGTAGTTTACCAAGAGTAGCTCGCTGCTATCGACAC AATCGCCTGCCTGTTGTATGTTGGAAGAACTCAAGAAGTGGTACTCTGCTCCTCCGATCTGGAGGATTCCATGGGAAGGGAGTCGTTGGT CTTTTCAAATCTCAGAACTCCCCTCAGGCCGCTCCTACCTCCTCTTTAGAATCTTCCAGTAGCATAGAACAAGAGAAATACTTGCAAGCC TTACTGAATGCTGTTTCTGTCCATCAGAAACTCAGAGGCAACAGCACTCTTACTGTCAGGCCAGCCTTTGCTCTATCTCCAGGTGTGTGG GCAAGTCTTCGCTCTAGCACTCGCTTGATCAGCTCTCCAACATCCTTCATTGATGTTGGCGCCCGGCTGGCAGGCAAGGATCACTCGGCC TCCTTCAGTAACAGCAGCTACCTACAAAACCAGCTCTTGAAACGGCAAGCAGCCCTTTACATATTTGGTGAAAAGTCGCAACTAAGGAAC TTCAAGGTAGAATTTGCTTTAAATTGTGAGTTTGTTCCTGTTGAATTTCATGAAATCCGGCAAGTGAAAGCCAGTTTTAAGAAGCTGATG AGGGCTTGTATCCCAAGCACCATCCCTACTGACTCAGAAGTGACCTTCCTGAAAGCGCTGGGAGATTCTGAGTGGTTCCCACAGCTTCAC AGGATAATGCAGCTGGCTGTGGTTGTATCAGAAGTACTTGAGAATGGTTCCTCAGTTTTGGTCTGTTTGGAGGAAGGCTGGGACATCACT GCACAAGTGACATCCCTGGTTCAGTTACTCAGTGATCCCTTTTATAGGACACTTGAAGGCTTCCAGATGTTGGTTGAAAAAGAGTGGCTC TCTTTTGGTCACAAATTCAGTCAGAGGAGCAGCTTGACCCTCAACTGTCAGGGGAGTGGTTTTGCTCCAGTCTTCTTACAGTTCTTAGAC TGTGTACACCAGGTTCACAACCAGTATCCAACTGAGTTTGAATTCAATCTCTATTACTTAAAGTTCTTGGCTTTCCACTATGTGTCTAAT CGCTTTAAAACATTTCTCCTGGATTCAGACTATGAAAGATTAGAGCACGGAACTTTATTTGATGATAAAGGAGAAAAGCATGCCAAAAAA GGAGTCTGTATTTGGGAATGTATTGACAGAATGCACAAGAGGAGTCCCATTTTCTTTAATTATTTATATTCACCATTGGAAATAGAGGCT CTAAAGCCCAATGTAAACGTCTCTAGCCTCAAGAAGTGGGATTACTACATAGAAGAGACCCTGTCCACAGGCCCTTCCTATGACTGGATG ATGCTAACCCCCAAGCACTTCCCCTCCGAAGACTCTGACCTGGCTGGAGAAGCTGGGCCACGGAGCCAGAGGAGAACAGTGTGGCCATGC TATGATGATGTCAGCTGTACTCAGCCTGATGCTCTCACCAGCCTTTTCAGTGAAATTGAAAAATTGGAGCACAAATTGAACCAAGCCCCT GAGAAGTGGCAGCAGCTGTGGGAAAGGGTAACCGTGGACCTTAAAGAAGAACCAAGAACAGATCGCTCCCAAAGACACCTGTCGAGATCC CCAGGAATTGTGTCTACCAACCTACCTTCCTATCAGAAGAGGTCTCTGCTACATCTCCCAGACAGCAGCATGGGGGAGGAACAGAATTCC AGCATCTCCCCATCCAATGGAGTGGAGCGAAGAGCAGCCACGCTCTATAGCCAGTATACATCCAAGAATGATGAAAACAGGTCCTTTGAG GGAACACTTTATAAAAGAGGGGCTTTGCTGAAAGGTTGGAAGCCCCGTTGGTTTGTTTTGGATGTAACAAAACATCAGCTGCGCTACTAT GACTCAGGTGAGGACACAAGCTGTAAAGGCCACATTGATCTGGCTGAAGTAGAAATGGTCATCCCTGCTGGCCCCAGCATGGGAGCCCCA AAGCACACAAGTGACAAGGCTTTCTTTGATCTCAAGACCAGCAAACGTGTGTATAACTTCTGCGCCCAGGATGGACAGAGTGCCCAGCAA TGGATGGACAAGATCCAGAGTTGTATCTCTGATGCCTGATGCCCATGGTCAACCCACGCAGAAGAAACAGAAGAACTCATGCTGCCAGAT AGATAGAAAAAGAAGCATGGATCCTTGAGGAGCTGACAACAAGTTATCCCAGGGCCTGAGGTTCTCCTGCCCAGTCCCCTCTTGCAGGGG TTGCTATATCTACTTAACCTGAATAGGTGTTTCACACAGGTCTGGTCAACAGCCCCATGCACTCCCTGTATCTTGCACTAAATTTTTCTA ACAGGGTCTTAGTGGTTAATGATCAGAAGATGTCTCCTGAGCCAACTGTGAACCTCACCCAGGCAAAATGGCTACCACCTACTTGGGTCC TTCTTCATGAAAGCTATAGATCCTTTTTTGTTCTCTGAGGTCATAATTTCCTCGGAGACCTGTTTAACAAGCAAAAATCAAAACCCTCCA AGATTGTCTCATATTCTACCTGGACTAGGTTTCCTATGAGAGACATCTACTTGTAATGCCTGACCTTTGAGATGCTCAGTTCTCTGGTGC TGCCAAAAGATGCTTCCATGGTCCGTGCTCTGCCAGTGGGGTTCACAACAAGAGACGTCATTGTTCAGTAGCAGGCAAAGAGGGAGCACA CAGCATTATTCTGATGGAAAAAGATTATCCAGGGAATGGTACAACAATGACCAGCCCAATGCAGGAAAACACTACTTCCAAAACACTGAA TTCTCTAGACCAGAGGTGCTCTGAGGATCCAGGGCCTTGTGTTCTTATGTATCTTCTGCTTCCTGACAGCTTCTTTTTCAAAATAACATG CAAAAAAAGCTGAATGCACTAACTCACAAAACAAACACTTGCACTGAATTCCCAATGAAGTGAAGATGTTGGAAAGACAGAGGCCAGCTA TTTAGGACCATACGCACCTGTGACAAGGGCTGTGTTGACCACAGTCACACTGTGGCATGACTGGATACCCAAACTACACTTCTACACATG AAAAGTAAGAACTGTCTTTAGATTTTCTTTACTTTGATAACTTGTGATTGTTTAGCTTAAGACCCAAGAAATGCTGTTTGCTCATGGTAA ACAGAAACAGCATCTTCGCTACAACCACTGACACCAGCTGGCGTCATAGGTAGCTAGATCATTGCATTTGTTTTGAAATGTTAATATGTT AAATACTAAACTAATATTTCAAAAATGTGTATATATGATTTCTATATCCTTGTTTTTCAGATAGCCTGCTTATAATTTAATATAAATTAA CTGATGCATTCATAAGATTTCAATAATGAAATGGTTCCCTTTTAAAAAATAAAAATACTTTGTAGATTAAAAATAAATCAGAATTTCAAA TTTAAAATTGTCCACACACTAGGAAATAGAACTGTGTTAATATATAAGAAATCTGGGGATAATTAAGAATGAAGGACTTTTCTATCATTT CCATTTTATAAATTGCCACCTGTGAAAATGGTTTTTGCACATTATTTGTATTTTTCTTTGTATATGAAATAATTTTTTGTACTTTGTAAA ATATGGAGCCCATTGTACCTTCAGCTATTTGAGACTATACACAGTGCTTCTTTTGTAACTGGATTACTTTAACTTTCGTGAAGGCATTAC ATTGCCTCACATTCACTAACCACCTTGAATTAAATTTATTTCTTAAGAAAAAGCATCCCTCATTTACTGTGAACTAAAGTTCATTCTGTA >In-frame_ENST00000328194_ENST00000256190_TCGA-D8-A1XT_DENND5A_chr11_9215040_-_SBF2_chr11_9879943_length(amino acids)=1612AA_start in transcript=240_stop in transcript=5078 MRADGRAPGLRGLGAAPHCPAGLGPGAMSGGGGGGGSAPSRFADYFVICGLDTETGLEPDELSALCQYIQASKARDGASPFISSTTEGEN FEQTPLRRTFKSKVLARYPENVEWNPFDQDAVGMLCMPKGLAFKTQADPREPQFHAFIITREDGSRTFGFALTFYEEVTSKQICSAMQTL YHMHNAEYDVLHAPPADDRDQSSMEDGEDTPVTKLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQPPPLPLESY IYNVLYEVPLPPPGRSLKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMF PFQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDRSKLELPQEKLAPGVSQFAYTCVQDHPIWTNQQFWETTFYNAVQEQVRSLYLS AKEDNHAPHLKQKDKLPDDHYQEKTAMDLAAEQLRLWPTLSKSTQQELVQHEESTVFSQAIHFANLMVNLLVPLDTSKNKLLRTSAPGDW ESGSNSIVTNSIAGSVAESYDTESGFEDSENTDIANSVVRFITRFIDKVCTESGVTQDHIKSLHCMIPGIVAMHIETLEAVHRESRRLPP IQKPKILRPALLPGEEIVCEGLRVLLDPDGREEATGGLLGGPQLLPAEGALFLTTYRILFRGTPHDQLVGEQTVVRSFPIASITKEKKIT MQNQLQQNMQEGLQITSASFQLIKVAFDEEVSPEVVEIFKKQLMKFRYPQSIFSTFAFAAGQTTPQIILPKQKEKNTSFRTFSKTIVKGA KRAGKMTIGRQYLLKKKTGTIVEERVNRPGWNEDDDVSVSDESELPTSTTLKASEKSTMEQLVEKACFRDYQRLGLGTISGSSSRSRPEY FRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRSGGFHGKGVVGLFKSQNSPQAAPTSSLESSS SIEQEKYLQALLNAVSVHQKLRGNSTLTVRPAFALSPGVWASLRSSTRLISSPTSFIDVGARLAGKDHSASFSNSSYLQNQLLKRQAALY IFGEKSQLRNFKVEFALNCEFVPVEFHEIRQVKASFKKLMRACIPSTIPTDSEVTFLKALGDSEWFPQLHRIMQLAVVVSEVLENGSSVL VCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQMLVEKEWLSFGHKFSQRSSLTLNCQGSGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYL KFLAFHYVSNRFKTFLLDSDYERLEHGTLFDDKGEKHAKKGVCIWECIDRMHKRSPIFFNYLYSPLEIEALKPNVNVSSLKKWDYYIEET LSTGPSYDWMMLTPKHFPSEDSDLAGEAGPRSQRRTVWPCYDDVSCTQPDALTSLFSEIEKLEHKLNQAPEKWQQLWERVTVDLKEEPRT DRSQRHLSRSPGIVSTNLPSYQKRSLLHLPDSSMGEEQNSSISPSNGVERRAATLYSQYTSKNDENRSFEGTLYKRGALLKGWKPRWFVL -------------------------------------------------------------- >In-frame_ENST00000530044_ENST00000256190_TCGA-D8-A1XT_DENND5A_chr11_9215040_-_SBF2_chr11_9879943_length(transcript)=6527nt_BP=1155nt GGTCTCGGCCCCGGCGCCATGAGTGGCGGCGGCGGCGGAGGGGGCTCGGCGCCCAGTCGCTTCGCCGACTACTTTGTCATCTGCGGACTG GACACGGAGACCGGGCTGGAGCCGGACGAGCTGTCGGCATTATGCCAGTACATACAGGCTTCTAAAGCCAGGGATGGTGCCAGCCCTTTC ATTTCAAGTACGACTGAAGGAGAAAATTTTGAGCAGACACCATTGAGAAGAACATTCAAATCTAAGGTCCTTGCACGATATCCTGAGAAC GTAGAATGGAATCCCTTTGACCAAGATGCAGTAGGAATGCTATGTATGCCGAAAGGGCTGGCATTCAAGACCCAGGCTGATCCCAGGGAG CCCCAATTCCATGCCTTTATTATCACAAGGGAGGATGGCTCTCGGACATTTGGGTTTGCCCTCACATTTTATGAAGAGGTGACTAGCAAG CAGATCTGCAGTGCAATGCAGACCCTCTACCACATGCACAATGCTGAGTATGATGTCCTACATGCTCCCCCTGCTGATGACAGAGACCAG AGCAGCATGGAGGATGGTGAAGACACTCCTGTGACCAAACTGCAGCGCTTCAACTCCTATGACATTAGCCGGGACACTCTCTACGTCTCT AAGTGCATCTGCCTCATCACACCCATGTCTTTCATGAAGGCATGTCGGAGCGTGCTGGAGCAACTCCACCAGGCAGTCACTTCACCTCAG CCCCCTCCACTGCCCCTTGAGAGCTACATATACAACGTACTCTACGAGGTGCCGCTCCCACCTCCTGGCCGGTCCTTGAAGTTTTCTGGG GTCTATGGGCCAATAATCTGCCAGAGACCAAGTACCAATGAGCTTCCCCTATTTGACTTTCCTGTCAAAGAGGTTTTTGAACTGCTCGGG GTGGAGAATGTGTTTCAGCTTTTTACTTGTGCCCTTCTGGAGTTTCAAATCCTGCTCTACTCACAGCATTACCAGAGACTGATGACTGTG GCGGAGACGATTACAGCTCTCATGTTTCCTTTCCAGTGGCAGCATGTCTATGTCCCTATTCTCCCAGCTTCTCTCCTGCATTTCTTAGAT GCTCCTGTTCCATACCTGATGGGTTTGCATTCCAATGGCCTGGATGACCGGTCAAAGCTGGAGCTGCCTCAAGAGAAACTTGCCCCTGGA GTCAGCCAGTTTGCTTACACGTGTGTACAAGACCACCCCATTTGGACAAATCAGCAATTTTGGGAGACAACCTTTTACAATGCAGTGCAG GAACAGGTTCGCTCCCTTTATCTCTCAGCCAAGGAAGACAATCATGCCCCGCATCTGAAGCAAAAGGATAAGCTTCCTGATGACCATTAT CAGGAGAAGACAGCAATGGACCTGGCAGCTGAGCAACTACGCCTTTGGCCTACCCTGAGCAAGTCAACTCAGCAAGAGCTAGTGCAACAT GAGGAAAGCACTGTCTTTAGTCAGGCCATTCACTTTGCAAACCTCATGGTGAACCTGCTAGTTCCACTCGACACAAGTAAAAACAAGCTC CTAAGAACATCAGCGCCAGGTGACTGGGAGAGCGGAAGCAACAGCATTGTCACAAACAGTATTGCAGGAAGTGTAGCTGAGAGCTATGAT ACAGAGAGTGGGTTTGAAGATTCAGAGAATACTGACATTGCCAATTCTGTTGTGCGGTTCATTACCCGATTTATTGACAAAGTTTGTACA GAGAGTGGAGTTACTCAGGATCACATCAAGAGCCTTCATTGCATGATACCAGGAATTGTAGCTATGCACATTGAGACCCTAGAAGCAGTA CATCGAGAAAGCAGAAGACTTCCGCCTATTCAGAAGCCCAAGATTCTTAGACCTGCTCTGCTGCCAGGAGAAGAAATTGTCTGTGAGGGT CTTCGAGTCTTGCTGGATCCTGATGGAAGAGAAGAAGCTACTGGAGGTCTTCTTGGAGGCCCTCAGCTCCTGCCAGCAGAAGGAGCCTTG TTCCTCACCACATACAGAATTCTCTTCAGAGGAACACCCCATGATCAGTTAGTGGGTGAGCAGACAGTTGTGCGGAGCTTTCCCATTGCC TCCATCACCAAGGAGAAGAAGATTACAATGCAGAACCAGCTACAGCAGAACATGCAAGAAGGACTGCAGATCACATCAGCATCTTTTCAG TTGATTAAGGTAGCATTTGATGAAGAAGTCAGTCCAGAAGTAGTAGAGATCTTTAAGAAACAGCTGATGAAGTTCCGTTATCCTCAGTCC ATTTTCAGTACCTTTGCTTTTGCTGCTGGACAAACTACCCCACAAATAATTTTACCAAAACAGAAGGAAAAGAACACTTCTTTTCGTACC TTCTCAAAAACAATTGTGAAAGGTGCCAAAAGGGCAGGGAAAATGACAATTGGGCGGCAATATTTACTGAAGAAGAAGACAGGGACAATT GTGGAAGAAAGAGTAAATCGTCCTGGATGGAATGAAGATGATGATGTATCTGTTTCAGATGAGAGTGAGCTCCCCACAAGTACCACCCTG AAGGCCTCCGAGAAGTCTACAATGGAACAGTTGGTGGAAAAAGCTTGTTTCAGAGACTATCAGCGTTTAGGTTTAGGAACCATAAGTGGC AGCTCTTCCCGTTCAAGACCCGAGTATTTTAGAATTACTGCCTCCAACAGGATGTATTCACTCTGCCGGAGCTATCCTGGCCTTTTAGTC GTACCTCAAGCTGTACAGGACAGTAGTTTACCAAGAGTAGCTCGCTGCTATCGACACAATCGCCTGCCTGTTGTATGTTGGAAGAACTCA AGAAGTGGTACTCTGCTCCTCCGATCTGGAGGATTCCATGGGAAGGGAGTCGTTGGTCTTTTCAAATCTCAGAACTCCCCTCAGGCCGCT CCTACCTCCTCTTTAGAATCTTCCAGTAGCATAGAACAAGAGAAATACTTGCAAGCCTTACTGAATGCTGTTTCTGTCCATCAGAAACTC AGAGGCAACAGCACTCTTACTGTCAGGCCAGCCTTTGCTCTATCTCCAGGTGTGTGGGCAAGTCTTCGCTCTAGCACTCGCTTGATCAGC TCTCCAACATCCTTCATTGATGTTGGCGCCCGGCTGGCAGGCAAGGATCACTCGGCCTCCTTCAGTAACAGCAGCTACCTACAAAACCAG CTCTTGAAACGGCAAGCAGCCCTTTACATATTTGGTGAAAAGTCGCAACTAAGGAACTTCAAGGTAGAATTTGCTTTAAATTGTGAGTTT GTTCCTGTTGAATTTCATGAAATCCGGCAAGTGAAAGCCAGTTTTAAGAAGCTGATGAGGGCTTGTATCCCAAGCACCATCCCTACTGAC TCAGAAGTGACCTTCCTGAAAGCGCTGGGAGATTCTGAGTGGTTCCCACAGCTTCACAGGATAATGCAGCTGGCTGTGGTTGTATCAGAA GTACTTGAGAATGGTTCCTCAGTTTTGGTCTGTTTGGAGGAAGGCTGGGACATCACTGCACAAGTGACATCCCTGGTTCAGTTACTCAGT GATCCCTTTTATAGGACACTTGAAGGCTTCCAGATGTTGGTTGAAAAAGAGTGGCTCTCTTTTGGTCACAAATTCAGTCAGAGGAGCAGC TTGACCCTCAACTGTCAGGGGAGTGGTTTTGCTCCAGTCTTCTTACAGTTCTTAGACTGTGTACACCAGGTTCACAACCAGTATCCAACT GAGTTTGAATTCAATCTCTATTACTTAAAGTTCTTGGCTTTCCACTATGTGTCTAATCGCTTTAAAACATTTCTCCTGGATTCAGACTAT GAAAGATTAGAGCACGGAACTTTATTTGATGATAAAGGAGAAAAGCATGCCAAAAAAGGAGTCTGTATTTGGGAATGTATTGACAGAATG CACAAGAGGAGTCCCATTTTCTTTAATTATTTATATTCACCATTGGAAATAGAGGCTCTAAAGCCCAATGTAAACGTCTCTAGCCTCAAG AAGTGGGATTACTACATAGAAGAGACCCTGTCCACAGGCCCTTCCTATGACTGGATGATGCTAACCCCCAAGCACTTCCCCTCCGAAGAC TCTGACCTGGCTGGAGAAGCTGGGCCACGGAGCCAGAGGAGAACAGTGTGGCCATGCTATGATGATGTCAGCTGTACTCAGCCTGATGCT CTCACCAGCCTTTTCAGTGAAATTGAAAAATTGGAGCACAAATTGAACCAAGCCCCTGAGAAGTGGCAGCAGCTGTGGGAAAGGGTAACC GTGGACCTTAAAGAAGAACCAAGAACAGATCGCTCCCAAAGACACCTGTCGAGATCCCCAGGAATTGTGTCTACCAACCTACCTTCCTAT CAGAAGAGGTCTCTGCTACATCTCCCAGACAGCAGCATGGGGGAGGAACAGAATTCCAGCATCTCCCCATCCAATGGAGTGGAGCGAAGA GCAGCCACGCTCTATAGCCAGTATACATCCAAGAATGATGAAAACAGGTCCTTTGAGGGAACACTTTATAAAAGAGGGGCTTTGCTGAAA GGTTGGAAGCCCCGTTGGTTTGTTTTGGATGTAACAAAACATCAGCTGCGCTACTATGACTCAGGTGAGGACACAAGCTGTAAAGGCCAC ATTGATCTGGCTGAAGTAGAAATGGTCATCCCTGCTGGCCCCAGCATGGGAGCCCCAAAGCACACAAGTGACAAGGCTTTCTTTGATCTC AAGACCAGCAAACGTGTGTATAACTTCTGCGCCCAGGATGGACAGAGTGCCCAGCAATGGATGGACAAGATCCAGAGTTGTATCTCTGAT GCCTGATGCCCATGGTCAACCCACGCAGAAGAAACAGAAGAACTCATGCTGCCAGATAGATAGAAAAAGAAGCATGGATCCTTGAGGAGC TGACAACAAGTTATCCCAGGGCCTGAGGTTCTCCTGCCCAGTCCCCTCTTGCAGGGGTTGCTATATCTACTTAACCTGAATAGGTGTTTC ACACAGGTCTGGTCAACAGCCCCATGCACTCCCTGTATCTTGCACTAAATTTTTCTAACAGGGTCTTAGTGGTTAATGATCAGAAGATGT CTCCTGAGCCAACTGTGAACCTCACCCAGGCAAAATGGCTACCACCTACTTGGGTCCTTCTTCATGAAAGCTATAGATCCTTTTTTGTTC TCTGAGGTCATAATTTCCTCGGAGACCTGTTTAACAAGCAAAAATCAAAACCCTCCAAGATTGTCTCATATTCTACCTGGACTAGGTTTC CTATGAGAGACATCTACTTGTAATGCCTGACCTTTGAGATGCTCAGTTCTCTGGTGCTGCCAAAAGATGCTTCCATGGTCCGTGCTCTGC CAGTGGGGTTCACAACAAGAGACGTCATTGTTCAGTAGCAGGCAAAGAGGGAGCACACAGCATTATTCTGATGGAAAAAGATTATCCAGG GAATGGTACAACAATGACCAGCCCAATGCAGGAAAACACTACTTCCAAAACACTGAATTCTCTAGACCAGAGGTGCTCTGAGGATCCAGG GCCTTGTGTTCTTATGTATCTTCTGCTTCCTGACAGCTTCTTTTTCAAAATAACATGCAAAAAAAGCTGAATGCACTAACTCACAAAACA AACACTTGCACTGAATTCCCAATGAAGTGAAGATGTTGGAAAGACAGAGGCCAGCTATTTAGGACCATACGCACCTGTGACAAGGGCTGT GTTGACCACAGTCACACTGTGGCATGACTGGATACCCAAACTACACTTCTACACATGAAAAGTAAGAACTGTCTTTAGATTTTCTTTACT TTGATAACTTGTGATTGTTTAGCTTAAGACCCAAGAAATGCTGTTTGCTCATGGTAAACAGAAACAGCATCTTCGCTACAACCACTGACA CCAGCTGGCGTCATAGGTAGCTAGATCATTGCATTTGTTTTGAAATGTTAATATGTTAAATACTAAACTAATATTTCAAAAATGTGTATA TATGATTTCTATATCCTTGTTTTTCAGATAGCCTGCTTATAATTTAATATAAATTAACTGATGCATTCATAAGATTTCAATAATGAAATG GTTCCCTTTTAAAAAATAAAAATACTTTGTAGATTAAAAATAAATCAGAATTTCAAATTTAAAATTGTCCACACACTAGGAAATAGAACT GTGTTAATATATAAGAAATCTGGGGATAATTAAGAATGAAGGACTTTTCTATCATTTCCATTTTATAAATTGCCACCTGTGAAAATGGTT TTTGCACATTATTTGTATTTTTCTTTGTATATGAAATAATTTTTTGTACTTTGTAAAATATGGAGCCCATTGTACCTTCAGCTATTTGAG ACTATACACAGTGCTTCTTTTGTAACTGGATTACTTTAACTTTCGTGAAGGCATTACATTGCCTCACATTCACTAACCACCTTGAATTAA ATTTATTTCTTAAGAAAAAGCATCCCTCATTTACTGTGAACTAAAGTTCATTCTGTAGTGCACAGCATTCAGGAGGGTAACACTCAGGAT >In-frame_ENST00000530044_ENST00000256190_TCGA-D8-A1XT_DENND5A_chr11_9215040_-_SBF2_chr11_9879943_length(amino acids)=1585AA_start in transcript=18_stop in transcript=4775 MSGGGGGGGSAPSRFADYFVICGLDTETGLEPDELSALCQYIQASKARDGASPFISSTTEGENFEQTPLRRTFKSKVLARYPENVEWNPF DQDAVGMLCMPKGLAFKTQADPREPQFHAFIITREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPPADDRDQSSMEDG EDTPVTKLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQPPPLPLESYIYNVLYEVPLPPPGRSLKFSGVYGPII CQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYL MGLHSNGLDDRSKLELPQEKLAPGVSQFAYTCVQDHPIWTNQQFWETTFYNAVQEQVRSLYLSAKEDNHAPHLKQKDKLPDDHYQEKTAM DLAAEQLRLWPTLSKSTQQELVQHEESTVFSQAIHFANLMVNLLVPLDTSKNKLLRTSAPGDWESGSNSIVTNSIAGSVAESYDTESGFE DSENTDIANSVVRFITRFIDKVCTESGVTQDHIKSLHCMIPGIVAMHIETLEAVHRESRRLPPIQKPKILRPALLPGEEIVCEGLRVLLD PDGREEATGGLLGGPQLLPAEGALFLTTYRILFRGTPHDQLVGEQTVVRSFPIASITKEKKITMQNQLQQNMQEGLQITSASFQLIKVAF DEEVSPEVVEIFKKQLMKFRYPQSIFSTFAFAAGQTTPQIILPKQKEKNTSFRTFSKTIVKGAKRAGKMTIGRQYLLKKKTGTIVEERVN RPGWNEDDDVSVSDESELPTSTTLKASEKSTMEQLVEKACFRDYQRLGLGTISGSSSRSRPEYFRITASNRMYSLCRSYPGLLVVPQAVQ DSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRSGGFHGKGVVGLFKSQNSPQAAPTSSLESSSSIEQEKYLQALLNAVSVHQKLRGNSTL TVRPAFALSPGVWASLRSSTRLISSPTSFIDVGARLAGKDHSASFSNSSYLQNQLLKRQAALYIFGEKSQLRNFKVEFALNCEFVPVEFH EIRQVKASFKKLMRACIPSTIPTDSEVTFLKALGDSEWFPQLHRIMQLAVVVSEVLENGSSVLVCLEEGWDITAQVTSLVQLLSDPFYRT LEGFQMLVEKEWLSFGHKFSQRSSLTLNCQGSGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYERLEHG TLFDDKGEKHAKKGVCIWECIDRMHKRSPIFFNYLYSPLEIEALKPNVNVSSLKKWDYYIEETLSTGPSYDWMMLTPKHFPSEDSDLAGE AGPRSQRRTVWPCYDDVSCTQPDALTSLFSEIEKLEHKLNQAPEKWQQLWERVTVDLKEEPRTDRSQRHLSRSPGIVSTNLPSYQKRSLL HLPDSSMGEEQNSSISPSNGVERRAATLYSQYTSKNDENRSFEGTLYKRGALLKGWKPRWFVLDVTKHQLRYYDSGEDTSCKGHIDLAEV -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for DENND5A-SBF2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for DENND5A-SBF2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for DENND5A-SBF2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | DENND5A | C0543888 | Epileptic encephalopathy | 2 | GENOMICS_ENGLAND |
| Hgene | DENND5A | C4310635 | EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 49 | 2 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| Tgene | SBF2 | C1858278 | Charcot-Marie-Tooth disease, Type 4B2 | 2 | CTD_human;GENOMICS_ENGLAND |
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