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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DGKD-UGT1A1 (FusionGDB2 ID:22443)

Fusion Gene Summary for DGKD-UGT1A1

check button Fusion gene summary
Fusion gene informationFusion gene name: DGKD-UGT1A1
Fusion gene ID: 22443
HgeneTgene
Gene symbol

DGKD

UGT1A1

Gene ID

8527

54658

Gene namediacylglycerol kinase deltaUDP glucuronosyltransferase family 1 member A1
SynonymsDGK-delta|DGKdelta|dgkd-2BILIQTL1|GNT1|HUG-BR1|UDPGT|UDPGT 1-1|UGT1|UGT1A
Cytomap

2q37.1

2q37.1

Type of geneprotein-codingprotein-coding
Descriptiondiacylglycerol kinase deltaDAG kinase deltadiacylglycerol kinase, delta 130kDadiglyceride kinase deltaUDP-glucuronosyltransferase 1-1UDP glucuronosyltransferase 1 family, polypeptide A1UDP glycosyltransferase 1 family, polypeptide A1UDP-glucuronosyltransferase 1-AUDP-glucuronosyltransferase 1A1UGT-1AUGT1*1UGT1-01UGT1.1bilirubin UDP-glucuronosyltr
Modification date2020031320200329
UniProtAcc

Q16760

.
Ensembl transtripts involved in fusion geneENST00000264057, ENST00000409813, 
ENST00000489613, 		ENST00000373450, 
ENST00000609637, ENST00000608381, 
ENST00000609767, ENST00000360418, 
ENST00000608383, 
Fusion gene scores* DoF score21 X 6 X 10=12605 X 1 X 6=30
# samples 236
** MAII scorelog2(23/1260*10)=-2.4537179674429
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/30*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DGKD [Title/Abstract] AND UGT1A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDGKD(234263320)-UGT1A1(234675680), # samples:1
DGKD(234299129)-UGT1A1(234675680), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDGKD

GO:0010033

response to organic substance

12200442

TgeneUGT1A1

GO:0051552

flavone metabolic process

18052087

TgeneUGT1A1

GO:0052695

cellular glucuronidation

17179145|22579593

TgeneUGT1A1

GO:0052696

flavonoid glucuronidation

20056724

TgeneUGT1A1

GO:0052697

xenobiotic glucuronidation

20056724


check buttonFusion gene breakpoints across DGKD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across UGT1A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-91-6836-01ADGKDchr2

234263320

+UGT1A1chr2

234675680

+
ChimerDB4STADTCGA-BR-8284-01ADGKDchr2

234299129

+UGT1A1chr2

234675680

+


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Fusion Gene ORF analysis for DGKD-UGT1A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000264057ENST00000373450DGKDchr2

234263320

+UGT1A1chr2

234675680

+
In-frameENST00000264057ENST00000609637DGKDchr2

234263320

+UGT1A1chr2

234675680

+
In-frameENST00000264057ENST00000608381DGKDchr2

234263320

+UGT1A1chr2

234675680

+
In-frameENST00000264057ENST00000609767DGKDchr2

234263320

+UGT1A1chr2

234675680

+
In-frameENST00000264057ENST00000360418DGKDchr2

234263320

+UGT1A1chr2

234675680

+
In-frameENST00000264057ENST00000608383DGKDchr2

234263320

+UGT1A1chr2

234675680

+
intron-3CDSENST00000409813ENST00000373450DGKDchr2

234263320

+UGT1A1chr2

234675680

+
intron-3CDSENST00000409813ENST00000609637DGKDchr2

234263320

+UGT1A1chr2

234675680

+
intron-3CDSENST00000409813ENST00000608381DGKDchr2

234263320

+UGT1A1chr2

234675680

+
intron-3CDSENST00000409813ENST00000609767DGKDchr2

234263320

+UGT1A1chr2

234675680

+
intron-3CDSENST00000409813ENST00000360418DGKDchr2

234263320

+UGT1A1chr2

234675680

+
intron-3CDSENST00000409813ENST00000608383DGKDchr2

234263320

+UGT1A1chr2

234675680

+
intron-3CDSENST00000489613ENST00000373450DGKDchr2

234263320

+UGT1A1chr2

234675680

+
intron-3CDSENST00000489613ENST00000609637DGKDchr2

234263320

+UGT1A1chr2

234675680

+
intron-3CDSENST00000489613ENST00000608381DGKDchr2

234263320

+UGT1A1chr2

234675680

+
intron-3CDSENST00000489613ENST00000609767DGKDchr2

234263320

+UGT1A1chr2

234675680

+
intron-3CDSENST00000489613ENST00000360418DGKDchr2

234263320

+UGT1A1chr2

234675680

+
intron-3CDSENST00000489613ENST00000608383DGKDchr2

234263320

+UGT1A1chr2

234675680

+
In-frameENST00000264057ENST00000373450DGKDchr2

234299129

+UGT1A1chr2

234675680

+
In-frameENST00000264057ENST00000609637DGKDchr2

234299129

+UGT1A1chr2

234675680

+
In-frameENST00000264057ENST00000608381DGKDchr2

234299129

+UGT1A1chr2

234675680

+
In-frameENST00000264057ENST00000609767DGKDchr2

234299129

+UGT1A1chr2

234675680

+
In-frameENST00000264057ENST00000360418DGKDchr2

234299129

+UGT1A1chr2

234675680

+
In-frameENST00000264057ENST00000608383DGKDchr2

234299129

+UGT1A1chr2

234675680

+
In-frameENST00000409813ENST00000373450DGKDchr2

234299129

+UGT1A1chr2

234675680

+
In-frameENST00000409813ENST00000609637DGKDchr2

234299129

+UGT1A1chr2

234675680

+
In-frameENST00000409813ENST00000608381DGKDchr2

234299129

+UGT1A1chr2

234675680

+
In-frameENST00000409813ENST00000609767DGKDchr2

234299129

+UGT1A1chr2

234675680

+
In-frameENST00000409813ENST00000360418DGKDchr2

234299129

+UGT1A1chr2

234675680

+
In-frameENST00000409813ENST00000608383DGKDchr2

234299129

+UGT1A1chr2

234675680

+
intron-3CDSENST00000489613ENST00000373450DGKDchr2

234299129

+UGT1A1chr2

234675680

+
intron-3CDSENST00000489613ENST00000609637DGKDchr2

234299129

+UGT1A1chr2

234675680

+
intron-3CDSENST00000489613ENST00000608381DGKDchr2

234299129

+UGT1A1chr2

234675680

+
intron-3CDSENST00000489613ENST00000609767DGKDchr2

234299129

+UGT1A1chr2

234675680

+
intron-3CDSENST00000489613ENST00000360418DGKDchr2

234299129

+UGT1A1chr2

234675680

+
intron-3CDSENST00000489613ENST00000608383DGKDchr2

234299129

+UGT1A1chr2

234675680

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264057DGKDchr2234263320+ENST00000373450UGT1A1chr2234675680+165716812905297
ENST00000264057DGKDchr2234263320+ENST00000609637UGT1A1chr2234675680+165016812905297
ENST00000264057DGKDchr2234263320+ENST00000608381UGT1A1chr2234675680+164616812905297
ENST00000264057DGKDchr2234263320+ENST00000609767UGT1A1chr2234675680+165016812905297
ENST00000264057DGKDchr2234263320+ENST00000360418UGT1A1chr2234675680+269316812638208
ENST00000264057DGKDchr2234263320+ENST00000608383UGT1A1chr2234675680+90616812905297
ENST00000264057DGKDchr2234299129+ENST00000373450UGT1A1chr2234675680+1849360121097361
ENST00000264057DGKDchr2234299129+ENST00000609637UGT1A1chr2234675680+1842360121097361
ENST00000264057DGKDchr2234299129+ENST00000608381UGT1A1chr2234675680+1838360121097361
ENST00000264057DGKDchr2234299129+ENST00000609767UGT1A1chr2234675680+1842360121097361
ENST00000264057DGKDchr2234299129+ENST00000360418UGT1A1chr2234675680+288536012830272
ENST00000264057DGKDchr2234299129+ENST00000608383UGT1A1chr2234675680+1098360121097361
ENST00000409813DGKDchr2234299129+ENST00000373450UGT1A1chr2234675680+1784295791032317
ENST00000409813DGKDchr2234299129+ENST00000609637UGT1A1chr2234675680+1777295791032317
ENST00000409813DGKDchr2234299129+ENST00000608381UGT1A1chr2234675680+1773295791032317
ENST00000409813DGKDchr2234299129+ENST00000609767UGT1A1chr2234675680+1777295791032317
ENST00000409813DGKDchr2234299129+ENST00000360418UGT1A1chr2234675680+282029579765228
ENST00000409813DGKDchr2234299129+ENST00000608383UGT1A1chr2234675680+1033295791032318

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264057ENST00000373450DGKDchr2234263320+UGT1A1chr2234675680+0.0011565650.99884343
ENST00000264057ENST00000609637DGKDchr2234263320+UGT1A1chr2234675680+0.0012044580.9987955
ENST00000264057ENST00000608381DGKDchr2234263320+UGT1A1chr2234675680+0.0012096810.9987903
ENST00000264057ENST00000609767DGKDchr2234263320+UGT1A1chr2234675680+0.0012044580.9987955
ENST00000264057ENST00000360418DGKDchr2234263320+UGT1A1chr2234675680+0.001137660.9988624
ENST00000264057ENST00000608383DGKDchr2234263320+UGT1A1chr2234675680+0.0032658850.99673414
ENST00000264057ENST00000373450DGKDchr2234299129+UGT1A1chr2234675680+0.0003237960.9996762
ENST00000264057ENST00000609637DGKDchr2234299129+UGT1A1chr2234675680+0.000338410.99966156
ENST00000264057ENST00000608381DGKDchr2234299129+UGT1A1chr2234675680+0.0003370050.999663
ENST00000264057ENST00000609767DGKDchr2234299129+UGT1A1chr2234675680+0.000338410.99966156
ENST00000264057ENST00000360418DGKDchr2234299129+UGT1A1chr2234675680+0.0005299560.99947006
ENST00000264057ENST00000608383DGKDchr2234299129+UGT1A1chr2234675680+0.0007787320.9992212
ENST00000409813ENST00000373450DGKDchr2234299129+UGT1A1chr2234675680+0.0005106890.9994893
ENST00000409813ENST00000609637DGKDchr2234299129+UGT1A1chr2234675680+0.0005278460.9994722
ENST00000409813ENST00000608381DGKDchr2234299129+UGT1A1chr2234675680+0.0005309740.999469
ENST00000409813ENST00000609767DGKDchr2234299129+UGT1A1chr2234675680+0.0005278460.9994722
ENST00000409813ENST00000360418DGKDchr2234299129+UGT1A1chr2234675680+0.0008414450.9991586
ENST00000409813ENST00000608383DGKDchr2234299129+UGT1A1chr2234675680+0.0008223910.99917763

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Fusion Genomic Features for DGKD-UGT1A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DGKDchr2234263320+UGT1A1chr2234675679+6.18E-060.9999938
DGKDchr2234299129+UGT1A1chr2234675679+2.24E-091
DGKDchr2234263320+UGT1A1chr2234675679+6.18E-060.9999938
DGKDchr2234299129+UGT1A1chr2234675679+2.24E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DGKD-UGT1A1


check button Go to

FGviewer for the breakpoints of chr2:234263320-chr2:234675680

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DGKD

Q16760

.
FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12200442, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development (By similarity). May also regulate clathrin-dependent endocytosis (PubMed:17880279). {ECO:0000250|UniProtKB:E9PUQ8, ECO:0000269|PubMed:12200442, ECO:0000269|PubMed:17880279, ECO:0000269|PubMed:23949095, ECO:0000305}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDGKDchr2:234263320chr2:234675680ENST00000264057+1308_3652.01215.0Compositional biasNote=Pro-rich
HgeneDGKDchr2:234299129chr2:234675680ENST00000264057+3308_36116.01215.0Compositional biasNote=Pro-rich
HgeneDGKDchr2:234299129chr2:234675680ENST00000409813+2298_3672.01171.0Compositional biasNote=Pro-rich
TgeneUGT1A1chr2:234263320chr2:234675680ENST0000037345005488_504285.0531.0TransmembraneHelical
TgeneUGT1A1chr2:234299129chr2:234675680ENST0000037345005488_504285.0531.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDGKDchr2:234263320chr2:234675680ENST00000409813+1298_3601171.0Compositional biasNote=Pro-rich
HgeneDGKDchr2:234263320chr2:234675680ENST00000264057+1301145_120852.01215.0DomainSAM
HgeneDGKDchr2:234263320chr2:234675680ENST00000264057+130317_45152.01215.0DomainDAGKc
HgeneDGKDchr2:234263320chr2:234675680ENST00000264057+13053_14652.01215.0DomainPH
HgeneDGKDchr2:234263320chr2:234675680ENST00000409813+1291145_120801171.0DomainSAM
HgeneDGKDchr2:234263320chr2:234675680ENST00000409813+129317_45101171.0DomainDAGKc
HgeneDGKDchr2:234263320chr2:234675680ENST00000409813+12953_14601171.0DomainPH
HgeneDGKDchr2:234299129chr2:234675680ENST00000264057+3301145_1208116.01215.0DomainSAM
HgeneDGKDchr2:234299129chr2:234675680ENST00000264057+330317_451116.01215.0DomainDAGKc
HgeneDGKDchr2:234299129chr2:234675680ENST00000264057+33053_146116.01215.0DomainPH
HgeneDGKDchr2:234299129chr2:234675680ENST00000409813+2291145_120872.01171.0DomainSAM
HgeneDGKDchr2:234299129chr2:234675680ENST00000409813+229317_45172.01171.0DomainDAGKc
HgeneDGKDchr2:234299129chr2:234675680ENST00000409813+22953_14672.01171.0DomainPH
HgeneDGKDchr2:234263320chr2:234675680ENST00000264057+130163_21352.01215.0Zinc fingerPhorbol-ester/DAG-type 1
HgeneDGKDchr2:234263320chr2:234675680ENST00000264057+130235_28652.01215.0Zinc fingerPhorbol-ester/DAG-type 2
HgeneDGKDchr2:234263320chr2:234675680ENST00000409813+129163_21301171.0Zinc fingerPhorbol-ester/DAG-type 1
HgeneDGKDchr2:234263320chr2:234675680ENST00000409813+129235_28601171.0Zinc fingerPhorbol-ester/DAG-type 2
HgeneDGKDchr2:234299129chr2:234675680ENST00000264057+330163_213116.01215.0Zinc fingerPhorbol-ester/DAG-type 1
HgeneDGKDchr2:234299129chr2:234675680ENST00000264057+330235_286116.01215.0Zinc fingerPhorbol-ester/DAG-type 2
HgeneDGKDchr2:234299129chr2:234675680ENST00000409813+229163_21372.01171.0Zinc fingerPhorbol-ester/DAG-type 1
HgeneDGKDchr2:234299129chr2:234675680ENST00000409813+229235_28672.01171.0Zinc fingerPhorbol-ester/DAG-type 2


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Fusion Gene Sequence for DGKD-UGT1A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000264057_ENST00000373450_TCGA-91-6836-01A_DGKD_chr2_234263320_+_UGT1A1_chr2_234675680_length(transcript)=1657nt_BP=168nt
TGGCCCGGCAGCATGGCGGCGGCGGCGGGCGCCCCTCCGCCGGGTCCCCCGCAACCGCCTCCGCCGCCGCCGCCCGAGGAGTCGTCCGAC
AGCGAGCCCGAGGCGGAGCCCGGCTCCCCACAGAAGCTCATCCGCAAGGTGTCCACGTCGGGTCAGATCCGACAGAAGGAATTTGAAGCC
TACATTAATGCTTCTGGAGAACATGGAATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATT
GCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCGAATCTTGCGAACAACACGATACTTGTT
AAGTGGCTACCCCAAAACGATCTGCTTGGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATA
TGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGCATGGAGACTAAGGGAGCTGGAGTGACC
CTGAATGTTCTGGAAATGACTTCTGAAGATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGC
CTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAGTTTGTGATGAGGCACAAGGGCGCGCCA
CACCTGCGCCCCGCAGCCCACGACCTCACCTGGTACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTG
GCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGAGTTAAGAAAGCCCACAAATCCAAGACC
CATTGAGAAGTGGGTGGGAAATAAGGTAAAATTTTGAACCATTCCCTAGTCATTTCCAAACTTGAAAACAGAATCAGTGTTAAATTCATT
TTATTCTTATTAAGGAAATACTTTGCATAAATTAATCAGCCCCAGAGTGCTTTAAAAAATTCTCTTAAATAAAAATAATAGACTCGCTAG
TCAGTAAAGATATTTGAATATGTATCGTGCCCCCTCTGGTGTCTTTGATCAGGATGACATGTGCCATTTTTCAGAGGACGTGCAGACAGG
CTGGCATTCTAGATTACTTTTCTTACTCTGAAACATGGCCTGTTTGGGAGTGCGGGATTCAAAGGTGGTCCCACGGCTGCCCCTACTGCA
AATGGCAGTTTTAATCTTATCTTTTGGCTTCTGCAGATGGTTGCAATTGATCCTTAACCAATAATGGTCAGTCCTCATCTCTGTCGTGCT
TCATAGGTGCCACCTTGTGTGTTTAAAGAAGGGAAGCTTTGTACCTTTAGAGTGTAGGTGAAATGAATGAATGGCTTGGAGTGCACTGAG
AACAGCATATGATTTCTTGCTTTGGGGAAAAAGAATGATGCTATGAAATTGGTGGGTGGTGTATTTGAGAAGATAATCATTGCTTATGTC
AAATGGAGCTGAATTTGATAAAAACCCAAAATACAGCTATGAAGTGCTGGGCAAGTTTACTTTTTTTCTGATGTTTCCTACAACTAAAAA

>In-frame_ENST00000264057_ENST00000373450_TCGA-91-6836-01A_DGKD_chr2_234263320_+_UGT1A1_chr2_234675680_length(amino acids)=297AA_start in transcript=12_stop in transcript=905
MAAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADAL
GKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVL
EMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFIT

--------------------------------------------------------------
>In-frame_ENST00000264057_ENST00000609637_TCGA-91-6836-01A_DGKD_chr2_234263320_+_UGT1A1_chr2_234675680_length(transcript)=1650nt_BP=168nt
TGGCCCGGCAGCATGGCGGCGGCGGCGGGCGCCCCTCCGCCGGGTCCCCCGCAACCGCCTCCGCCGCCGCCGCCCGAGGAGTCGTCCGAC
AGCGAGCCCGAGGCGGAGCCCGGCTCCCCACAGAAGCTCATCCGCAAGGTGTCCACGTCGGGTCAGATCCGACAGAAGGAATTTGAAGCC
TACATTAATGCTTCTGGAGAACATGGAATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATT
GCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCGAATCTTGCGAACAACACGATACTTGTT
AAGTGGCTACCCCAAAACGATCTGCTTGGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATA
TGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGCATGGAGACTAAGGGAGCTGGAGTGACC
CTGAATGTTCTGGAAATGACTTCTGAAGATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGC
CTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAGTTTGTGATGAGGCACAAGGGCGCGCCA
CACCTGCGCCCCGCAGCCCACGACCTCACCTGGTACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTG
GCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGAGTTAAGAAAGCCCACAAATCCAAGACC
CATTGAGAAGTGGGTGGGAAATAAGGTAAAATTTTGAACCATTCCCTAGTCATTTCCAAACTTGAAAACAGAATCAGTGTTAAATTCATT
TTATTCTTATTAAGGAAATACTTTGCATAAATTAATCAGCCCCAGAGTGCTTTAAAAAATTCTCTTAAATAAAAATAATAGACTCGCTAG
TCAGTAAAGATATTTGAATATGTATCGTGCCCCCTCTGGTGTCTTTGATCAGGATGACATGTGCCATTTTTCAGAGGACGTGCAGACAGG
CTGGCATTCTAGATTACTTTTCTTACTCTGAAACATGGCCTGTTTGGGAGTGCGGGATTCAAAGGTGGTCCCACGGCTGCCCCTACTGCA
AATGGCAGTTTTAATCTTATCTTTTGGCTTCTGCAGATGGTTGCAATTGATCCTTAACCAATAATGGTCAGTCCTCATCTCTGTCGTGCT
TCATAGGTGCCACCTTGTGTGTTTAAAGAAGGGAAGCTTTGTACCTTTAGAGTGTAGGTGAAATGAATGAATGGCTTGGAGTGCACTGAG
AACAGCATATGATTTCTTGCTTTGGGGAAAAAGAATGATGCTATGAAATTGGTGGGTGGTGTATTTGAGAAGATAATCATTGCTTATGTC
AAATGGAGCTGAATTTGATAAAAACCCAAAATACAGCTATGAAGTGCTGGGCAAGTTTACTTTTTTTCTGATGTTTCCTACAACTAAAAA

>In-frame_ENST00000264057_ENST00000609637_TCGA-91-6836-01A_DGKD_chr2_234263320_+_UGT1A1_chr2_234675680_length(amino acids)=297AA_start in transcript=12_stop in transcript=905
MAAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADAL
GKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVL
EMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFIT

--------------------------------------------------------------
>In-frame_ENST00000264057_ENST00000608381_TCGA-91-6836-01A_DGKD_chr2_234263320_+_UGT1A1_chr2_234675680_length(transcript)=1646nt_BP=168nt
TGGCCCGGCAGCATGGCGGCGGCGGCGGGCGCCCCTCCGCCGGGTCCCCCGCAACCGCCTCCGCCGCCGCCGCCCGAGGAGTCGTCCGAC
AGCGAGCCCGAGGCGGAGCCCGGCTCCCCACAGAAGCTCATCCGCAAGGTGTCCACGTCGGGTCAGATCCGACAGAAGGAATTTGAAGCC
TACATTAATGCTTCTGGAGAACATGGAATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATT
GCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCGAATCTTGCGAACAACACGATACTTGTT
AAGTGGCTACCCCAAAACGATCTGCTTGGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATA
TGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGCATGGAGACTAAGGGAGCTGGAGTGACC
CTGAATGTTCTGGAAATGACTTCTGAAGATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGC
CTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAGTTTGTGATGAGGCACAAGGGCGCGCCA
CACCTGCGCCCCGCAGCCCACGACCTCACCTGGTACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTG
GCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGAGTTAAGAAAGCCCACAAATCCAAGACC
CATTGAGAAGTGGGTGGGAAATAAGGTAAAATTTTGAACCATTCCCTAGTCATTTCCAAACTTGAAAACAGAATCAGTGTTAAATTCATT
TTATTCTTATTAAGGAAATACTTTGCATAAATTAATCAGCCCCAGAGTGCTTTAAAAAATTCTCTTAAATAAAAATAATAGACTCGCTAG
TCAGTAAAGATATTTGAATATGTATCGTGCCCCCTCTGGTGTCTTTGATCAGGATGACATGTGCCATTTTTCAGAGGACGTGCAGACAGG
CTGGCATTCTAGATTACTTTTCTTACTCTGAAACATGGCCTGTTTGGGAGTGCGGGATTCAAAGGTGGTCCCACGGCTGCCCCTACTGCA
AATGGCAGTTTTAATCTTATCTTTTGGCTTCTGCAGATGGTTGCAATTGATCCTTAACCAATAATGGTCAGTCCTCATCTCTGTCGTGCT
TCATAGGTGCCACCTTGTGTGTTTAAAGAAGGGAAGCTTTGTACCTTTAGAGTGTAGGTGAAATGAATGAATGGCTTGGAGTGCACTGAG
AACAGCATATGATTTCTTGCTTTGGGGAAAAAGAATGATGCTATGAAATTGGTGGGTGGTGTATTTGAGAAGATAATCATTGCTTATGTC
AAATGGAGCTGAATTTGATAAAAACCCAAAATACAGCTATGAAGTGCTGGGCAAGTTTACTTTTTTTCTGATGTTTCCTACAACTAAAAA

>In-frame_ENST00000264057_ENST00000608381_TCGA-91-6836-01A_DGKD_chr2_234263320_+_UGT1A1_chr2_234675680_length(amino acids)=297AA_start in transcript=12_stop in transcript=905
MAAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADAL
GKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVL
EMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFIT

--------------------------------------------------------------
>In-frame_ENST00000264057_ENST00000609767_TCGA-91-6836-01A_DGKD_chr2_234263320_+_UGT1A1_chr2_234675680_length(transcript)=1650nt_BP=168nt
TGGCCCGGCAGCATGGCGGCGGCGGCGGGCGCCCCTCCGCCGGGTCCCCCGCAACCGCCTCCGCCGCCGCCGCCCGAGGAGTCGTCCGAC
AGCGAGCCCGAGGCGGAGCCCGGCTCCCCACAGAAGCTCATCCGCAAGGTGTCCACGTCGGGTCAGATCCGACAGAAGGAATTTGAAGCC
TACATTAATGCTTCTGGAGAACATGGAATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATT
GCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCGAATCTTGCGAACAACACGATACTTGTT
AAGTGGCTACCCCAAAACGATCTGCTTGGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATA
TGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGCATGGAGACTAAGGGAGCTGGAGTGACC
CTGAATGTTCTGGAAATGACTTCTGAAGATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGC
CTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAGTTTGTGATGAGGCACAAGGGCGCGCCA
CACCTGCGCCCCGCAGCCCACGACCTCACCTGGTACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTG
GCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGAGTTAAGAAAGCCCACAAATCCAAGACC
CATTGAGAAGTGGGTGGGAAATAAGGTAAAATTTTGAACCATTCCCTAGTCATTTCCAAACTTGAAAACAGAATCAGTGTTAAATTCATT
TTATTCTTATTAAGGAAATACTTTGCATAAATTAATCAGCCCCAGAGTGCTTTAAAAAATTCTCTTAAATAAAAATAATAGACTCGCTAG
TCAGTAAAGATATTTGAATATGTATCGTGCCCCCTCTGGTGTCTTTGATCAGGATGACATGTGCCATTTTTCAGAGGACGTGCAGACAGG
CTGGCATTCTAGATTACTTTTCTTACTCTGAAACATGGCCTGTTTGGGAGTGCGGGATTCAAAGGTGGTCCCACGGCTGCCCCTACTGCA
AATGGCAGTTTTAATCTTATCTTTTGGCTTCTGCAGATGGTTGCAATTGATCCTTAACCAATAATGGTCAGTCCTCATCTCTGTCGTGCT
TCATAGGTGCCACCTTGTGTGTTTAAAGAAGGGAAGCTTTGTACCTTTAGAGTGTAGGTGAAATGAATGAATGGCTTGGAGTGCACTGAG
AACAGCATATGATTTCTTGCTTTGGGGAAAAAGAATGATGCTATGAAATTGGTGGGTGGTGTATTTGAGAAGATAATCATTGCTTATGTC
AAATGGAGCTGAATTTGATAAAAACCCAAAATACAGCTATGAAGTGCTGGGCAAGTTTACTTTTTTTCTGATGTTTCCTACAACTAAAAA

>In-frame_ENST00000264057_ENST00000609767_TCGA-91-6836-01A_DGKD_chr2_234263320_+_UGT1A1_chr2_234675680_length(amino acids)=297AA_start in transcript=12_stop in transcript=905
MAAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADAL
GKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVL
EMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFIT

--------------------------------------------------------------
>In-frame_ENST00000264057_ENST00000360418_TCGA-91-6836-01A_DGKD_chr2_234263320_+_UGT1A1_chr2_234675680_length(transcript)=2693nt_BP=168nt
TGGCCCGGCAGCATGGCGGCGGCGGCGGGCGCCCCTCCGCCGGGTCCCCCGCAACCGCCTCCGCCGCCGCCGCCCGAGGAGTCGTCCGAC
AGCGAGCCCGAGGCGGAGCCCGGCTCCCCACAGAAGCTCATCCGCAAGGTGTCCACGTCGGGTCAGATCCGACAGAAGGAATTTGAAGCC
TACATTAATGCTTCTGGAGAACATGGAATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATT
GCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCGAATCTTGCGAACAACACGATACTTGTT
AAGTGGCTACCCCAAAACGATCTGCTTGGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATA
TGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGCATGGAGACTAAGGGAGCTGGAGTGACC
CTGAATGTTCTGGAAATGACTTCTGAAGATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGAAAGAAGCAGCAGTCAGGAAGA
CAGATGTGAAGAGCTGGAGCATGTTCAGATGAGAGGAGACGGAACACGGGGACACACCAGCTTGAGCAAGGGACAACAGGGGAGGACTGA
TGACTGACTTCCCACCTTTGAGGTGCTAATGTGTGTGTGGTGGCACTGGATAAAAGATCAATGTTGGCTAGGCACCATGGCACACGCCTG
TAGTCCCAGCCACTCTGGAGGCTAAGGCGGGAGGATTGCTTGAGCCCAGAAGTTGGAGGCTGCTATGAGCCGTGATCATGCCACTGCACT
CCAGCAACCTGGGCAACAGAGTGAGACCCTGTCTCAAAAAAAAAAAAAAAAATGAAAAGTCCACATAACCTGAGCATCATGTGCCCAGAG
CGTTGGGTGGTGTGGTCCCATTCCTTCCTTCCAGCGGCTTCTTCTGGCCACCTCAATGTCAGGATGTCCTGCTCACATATCAATACCATT
AAAACCTGACTTCTTTCCCTGCACTGTTGAAGCTCCTTCTTGAGGCTCACATTATGGATATAATTTTGATTCTTTCTTCAGTGGTATAGA
TAACTACTTGTAACCTAAGAACAACTTGGTGAAAGTCCTCTAATACATTATTTTTTAAAAAAACACAAATCAATGAGCTCAACTTATTAA
CTAACTTTCATCTATTCATTTTTGAGCCATCCCTGTCTGATTGTGAATCTCCATGATTCCAACACTCTGAGCTGGGGATAGTGCCTACAC
AAAATAAAAAGAAGTGGAAAATTTTCAAACATCAGTTTATGCTGACAACCAGGCCATAATAGGTGCTCAATTACTATTGAATGAATGAAT
GAAAGTTCTGGCCAGGTACGGTGGCTCATGCCTGTAGTCCCAACACTTTGGGAGGCCGAGGCAGGTGGATCACTTGAGGTTAGGAGTTCG
AAACCAACCTGACCAACATGAAGAAACCTTATCTCTACCAAAAAAATATAAAAAAATTACCCAGGCATGGTGGTGTATGCCTGTAATCCC
AGCTATTTGGGAGGCTGAGGCAGGAAAATCACTTGAACCTGAGAGGCGGAGGTTGCAGTGAGCTGAGATTGTGCCACTCCACTCCAGCCT
GGGCGACAGAGTGAGACTCCGTCTTACTTAAAAAAAAAAAAAAGAAGGTTCCAAGAAAATTCATCTTAAGGTTTATGTAAAAGGAAGATG
ATATTTAACATGATTCATGGCCAAGTACTAATATTACATTATAATAATGTTTCCAAATAACATTATAGATATGTTTAAAGACAGTGTATT
AGGCTGTTCTTGCATTGCTGTAAAGAAATACCCAAGACTGGGTAATTTATAAAGAAAAGAGGTTTCATTGGCTCGTGTTTCTGCAGGCTG
TACAGGAAGCTTAGTGCTGACATCACTTGGCTGCCGGGGGAACCTCAGGGAGCTTTTACTCATGGCAGAAGGCAATGCGGGAGCTTGCAT
GTCACATGGCAAAAGCAGGAGCGAGAGAGAGTTGGGGGGGAAGGTGCCACACACTTTTTAATGACCGGCTCTCACAATAACTCATGAAAA
CTCACTATCAGGAAGACAGCACTAAAGCACAAGGGATCCGACCCCATGATCCAAACACCTCCCACCAGGCCCCATCTCCAGCACTGGGGA
TTACAATTCAACATGAGATCTGAGTGTGGACAAATATCCAAACTGTATCAGTCAACAGCGATCATAATTAGTCCTGAATAGGAGTGCCTT
TTTTTTTCTTTCTTCTCCCTTTTCTTTTCTACTTCCTCCTCCTTTTCCCTCTCCTCTTCAATCTCCTCTTCATTCCTGTAGCACCAAGGG
TTGAAGCACCTAACCCGTTTTGGATTGAGATGTTCTGATTGGGCAATGAACACTGTCCAGAATAAACAGAAATCCATTTTGCACTAAGTG
GCTGCACAGACCCTGCCTCATGCTAAATCTAGCACCCAGATAGTTTAATGTTTCAATGACTGAATTACAAATATATCATCACCTTGGATT

>In-frame_ENST00000264057_ENST00000360418_TCGA-91-6836-01A_DGKD_chr2_234263320_+_UGT1A1_chr2_234675680_length(amino acids)=208AA_start in transcript=12_stop in transcript=638
MAAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADAL
GKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVL

--------------------------------------------------------------
>In-frame_ENST00000264057_ENST00000608383_TCGA-91-6836-01A_DGKD_chr2_234263320_+_UGT1A1_chr2_234675680_length(transcript)=906nt_BP=168nt
TGGCCCGGCAGCATGGCGGCGGCGGCGGGCGCCCCTCCGCCGGGTCCCCCGCAACCGCCTCCGCCGCCGCCGCCCGAGGAGTCGTCCGAC
AGCGAGCCCGAGGCGGAGCCCGGCTCCCCACAGAAGCTCATCCGCAAGGTGTCCACGTCGGGTCAGATCCGACAGAAGGAATTTGAAGCC
TACATTAATGCTTCTGGAGAACATGGAATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATT
GCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCGAATCTTGCGAACAACACGATACTTGTT
AAGTGGCTACCCCAAAACGATCTGCTTGGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATA
TGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGCATGGAGACTAAGGGAGCTGGAGTGACC
CTGAATGTTCTGGAAATGACTTCTGAAGATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGC
CTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAGTTTGTGATGAGGCACAAGGGCGCGCCA
CACCTGCGCCCCGCAGCCCACGACCTCACCTGGTACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTG
GCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGAGTTAAGAAAGCCCACAAATCCAAGACC

>In-frame_ENST00000264057_ENST00000608383_TCGA-91-6836-01A_DGKD_chr2_234263320_+_UGT1A1_chr2_234675680_length(amino acids)=297AA_start in transcript=12_stop in transcript=905
MAAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADAL
GKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVL
EMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFIT

--------------------------------------------------------------
>In-frame_ENST00000264057_ENST00000373450_TCGA-BR-8284-01A_DGKD_chr2_234299129_+_UGT1A1_chr2_234675680_length(transcript)=1849nt_BP=360nt
TGGCCCGGCAGCATGGCGGCGGCGGCGGGCGCCCCTCCGCCGGGTCCCCCGCAACCGCCTCCGCCGCCGCCGCCCGAGGAGTCGTCCGAC
AGCGAGCCCGAGGCGGAGCCCGGCTCCCCACAGAAGCTCATCCGCAAGGTGTCCACGTCGGGTCAGATCCGACAGAAGACCATCATCAAA
GAGGGGATGCTGACCAAACAGAACAATTCATTCCAGCGATCAAAAAGGAGATACTTTAAGCTTCGAGGGCGAACGCTTTACTATGCCAAA
ACGGCAAAGTCAATCATATTTGATGAGGTGGATCTGACAGATGCCAGCGTAGCTGAATCCAGTACCAAAAACGTCAACAACAGTTTTACG
GAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAA
GCTATGGCAATTGCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCGAATCTTGCGAACAAC
ACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTT
TATGAAAGCATATGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGCATGGAGACTAAGGGA
GCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAG
AACATCATGCGCCTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAGTTTGTGATGAGGCAC
AAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGGTACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTC
GTGCTGACAGTGGCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGAGTTAAGAAAGCCCAC
AAATCCAAGACCCATTGAGAAGTGGGTGGGAAATAAGGTAAAATTTTGAACCATTCCCTAGTCATTTCCAAACTTGAAAACAGAATCAGT
GTTAAATTCATTTTATTCTTATTAAGGAAATACTTTGCATAAATTAATCAGCCCCAGAGTGCTTTAAAAAATTCTCTTAAATAAAAATAA
TAGACTCGCTAGTCAGTAAAGATATTTGAATATGTATCGTGCCCCCTCTGGTGTCTTTGATCAGGATGACATGTGCCATTTTTCAGAGGA
CGTGCAGACAGGCTGGCATTCTAGATTACTTTTCTTACTCTGAAACATGGCCTGTTTGGGAGTGCGGGATTCAAAGGTGGTCCCACGGCT
GCCCCTACTGCAAATGGCAGTTTTAATCTTATCTTTTGGCTTCTGCAGATGGTTGCAATTGATCCTTAACCAATAATGGTCAGTCCTCAT
CTCTGTCGTGCTTCATAGGTGCCACCTTGTGTGTTTAAAGAAGGGAAGCTTTGTACCTTTAGAGTGTAGGTGAAATGAATGAATGGCTTG
GAGTGCACTGAGAACAGCATATGATTTCTTGCTTTGGGGAAAAAGAATGATGCTATGAAATTGGTGGGTGGTGTATTTGAGAAGATAATC
ATTGCTTATGTCAAATGGAGCTGAATTTGATAAAAACCCAAAATACAGCTATGAAGTGCTGGGCAAGTTTACTTTTTTTCTGATGTTTCC

>In-frame_ENST00000264057_ENST00000373450_TCGA-BR-8284-01A_DGKD_chr2_234299129_+_UGT1A1_chr2_234675680_length(amino acids)=361AA_start in transcript=12_stop in transcript=1097
MAAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKS
IIFDEVDLTDASVAESSTKNVNNSFTEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILV
KWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMR
LSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKT

--------------------------------------------------------------
>In-frame_ENST00000264057_ENST00000609637_TCGA-BR-8284-01A_DGKD_chr2_234299129_+_UGT1A1_chr2_234675680_length(transcript)=1842nt_BP=360nt
TGGCCCGGCAGCATGGCGGCGGCGGCGGGCGCCCCTCCGCCGGGTCCCCCGCAACCGCCTCCGCCGCCGCCGCCCGAGGAGTCGTCCGAC
AGCGAGCCCGAGGCGGAGCCCGGCTCCCCACAGAAGCTCATCCGCAAGGTGTCCACGTCGGGTCAGATCCGACAGAAGACCATCATCAAA
GAGGGGATGCTGACCAAACAGAACAATTCATTCCAGCGATCAAAAAGGAGATACTTTAAGCTTCGAGGGCGAACGCTTTACTATGCCAAA
ACGGCAAAGTCAATCATATTTGATGAGGTGGATCTGACAGATGCCAGCGTAGCTGAATCCAGTACCAAAAACGTCAACAACAGTTTTACG
GAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAA
GCTATGGCAATTGCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCGAATCTTGCGAACAAC
ACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTT
TATGAAAGCATATGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGCATGGAGACTAAGGGA
GCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAG
AACATCATGCGCCTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAGTTTGTGATGAGGCAC
AAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGGTACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTC
GTGCTGACAGTGGCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGAGTTAAGAAAGCCCAC
AAATCCAAGACCCATTGAGAAGTGGGTGGGAAATAAGGTAAAATTTTGAACCATTCCCTAGTCATTTCCAAACTTGAAAACAGAATCAGT
GTTAAATTCATTTTATTCTTATTAAGGAAATACTTTGCATAAATTAATCAGCCCCAGAGTGCTTTAAAAAATTCTCTTAAATAAAAATAA
TAGACTCGCTAGTCAGTAAAGATATTTGAATATGTATCGTGCCCCCTCTGGTGTCTTTGATCAGGATGACATGTGCCATTTTTCAGAGGA
CGTGCAGACAGGCTGGCATTCTAGATTACTTTTCTTACTCTGAAACATGGCCTGTTTGGGAGTGCGGGATTCAAAGGTGGTCCCACGGCT
GCCCCTACTGCAAATGGCAGTTTTAATCTTATCTTTTGGCTTCTGCAGATGGTTGCAATTGATCCTTAACCAATAATGGTCAGTCCTCAT
CTCTGTCGTGCTTCATAGGTGCCACCTTGTGTGTTTAAAGAAGGGAAGCTTTGTACCTTTAGAGTGTAGGTGAAATGAATGAATGGCTTG
GAGTGCACTGAGAACAGCATATGATTTCTTGCTTTGGGGAAAAAGAATGATGCTATGAAATTGGTGGGTGGTGTATTTGAGAAGATAATC
ATTGCTTATGTCAAATGGAGCTGAATTTGATAAAAACCCAAAATACAGCTATGAAGTGCTGGGCAAGTTTACTTTTTTTCTGATGTTTCC

>In-frame_ENST00000264057_ENST00000609637_TCGA-BR-8284-01A_DGKD_chr2_234299129_+_UGT1A1_chr2_234675680_length(amino acids)=361AA_start in transcript=12_stop in transcript=1097
MAAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKS
IIFDEVDLTDASVAESSTKNVNNSFTEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILV
KWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMR
LSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKT

--------------------------------------------------------------
>In-frame_ENST00000264057_ENST00000608381_TCGA-BR-8284-01A_DGKD_chr2_234299129_+_UGT1A1_chr2_234675680_length(transcript)=1838nt_BP=360nt
TGGCCCGGCAGCATGGCGGCGGCGGCGGGCGCCCCTCCGCCGGGTCCCCCGCAACCGCCTCCGCCGCCGCCGCCCGAGGAGTCGTCCGAC
AGCGAGCCCGAGGCGGAGCCCGGCTCCCCACAGAAGCTCATCCGCAAGGTGTCCACGTCGGGTCAGATCCGACAGAAGACCATCATCAAA
GAGGGGATGCTGACCAAACAGAACAATTCATTCCAGCGATCAAAAAGGAGATACTTTAAGCTTCGAGGGCGAACGCTTTACTATGCCAAA
ACGGCAAAGTCAATCATATTTGATGAGGTGGATCTGACAGATGCCAGCGTAGCTGAATCCAGTACCAAAAACGTCAACAACAGTTTTACG
GAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAA
GCTATGGCAATTGCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCGAATCTTGCGAACAAC
ACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTT
TATGAAAGCATATGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGCATGGAGACTAAGGGA
GCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAG
AACATCATGCGCCTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAGTTTGTGATGAGGCAC
AAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGGTACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTC
GTGCTGACAGTGGCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGAGTTAAGAAAGCCCAC
AAATCCAAGACCCATTGAGAAGTGGGTGGGAAATAAGGTAAAATTTTGAACCATTCCCTAGTCATTTCCAAACTTGAAAACAGAATCAGT
GTTAAATTCATTTTATTCTTATTAAGGAAATACTTTGCATAAATTAATCAGCCCCAGAGTGCTTTAAAAAATTCTCTTAAATAAAAATAA
TAGACTCGCTAGTCAGTAAAGATATTTGAATATGTATCGTGCCCCCTCTGGTGTCTTTGATCAGGATGACATGTGCCATTTTTCAGAGGA
CGTGCAGACAGGCTGGCATTCTAGATTACTTTTCTTACTCTGAAACATGGCCTGTTTGGGAGTGCGGGATTCAAAGGTGGTCCCACGGCT
GCCCCTACTGCAAATGGCAGTTTTAATCTTATCTTTTGGCTTCTGCAGATGGTTGCAATTGATCCTTAACCAATAATGGTCAGTCCTCAT
CTCTGTCGTGCTTCATAGGTGCCACCTTGTGTGTTTAAAGAAGGGAAGCTTTGTACCTTTAGAGTGTAGGTGAAATGAATGAATGGCTTG
GAGTGCACTGAGAACAGCATATGATTTCTTGCTTTGGGGAAAAAGAATGATGCTATGAAATTGGTGGGTGGTGTATTTGAGAAGATAATC
ATTGCTTATGTCAAATGGAGCTGAATTTGATAAAAACCCAAAATACAGCTATGAAGTGCTGGGCAAGTTTACTTTTTTTCTGATGTTTCC

>In-frame_ENST00000264057_ENST00000608381_TCGA-BR-8284-01A_DGKD_chr2_234299129_+_UGT1A1_chr2_234675680_length(amino acids)=361AA_start in transcript=12_stop in transcript=1097
MAAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKS
IIFDEVDLTDASVAESSTKNVNNSFTEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILV
KWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMR
LSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKT

--------------------------------------------------------------
>In-frame_ENST00000264057_ENST00000609767_TCGA-BR-8284-01A_DGKD_chr2_234299129_+_UGT1A1_chr2_234675680_length(transcript)=1842nt_BP=360nt
TGGCCCGGCAGCATGGCGGCGGCGGCGGGCGCCCCTCCGCCGGGTCCCCCGCAACCGCCTCCGCCGCCGCCGCCCGAGGAGTCGTCCGAC
AGCGAGCCCGAGGCGGAGCCCGGCTCCCCACAGAAGCTCATCCGCAAGGTGTCCACGTCGGGTCAGATCCGACAGAAGACCATCATCAAA
GAGGGGATGCTGACCAAACAGAACAATTCATTCCAGCGATCAAAAAGGAGATACTTTAAGCTTCGAGGGCGAACGCTTTACTATGCCAAA
ACGGCAAAGTCAATCATATTTGATGAGGTGGATCTGACAGATGCCAGCGTAGCTGAATCCAGTACCAAAAACGTCAACAACAGTTTTACG
GAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAA
GCTATGGCAATTGCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCGAATCTTGCGAACAAC
ACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTT
TATGAAAGCATATGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGCATGGAGACTAAGGGA
GCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAG
AACATCATGCGCCTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAGTTTGTGATGAGGCAC
AAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGGTACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTC
GTGCTGACAGTGGCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGAGTTAAGAAAGCCCAC
AAATCCAAGACCCATTGAGAAGTGGGTGGGAAATAAGGTAAAATTTTGAACCATTCCCTAGTCATTTCCAAACTTGAAAACAGAATCAGT
GTTAAATTCATTTTATTCTTATTAAGGAAATACTTTGCATAAATTAATCAGCCCCAGAGTGCTTTAAAAAATTCTCTTAAATAAAAATAA
TAGACTCGCTAGTCAGTAAAGATATTTGAATATGTATCGTGCCCCCTCTGGTGTCTTTGATCAGGATGACATGTGCCATTTTTCAGAGGA
CGTGCAGACAGGCTGGCATTCTAGATTACTTTTCTTACTCTGAAACATGGCCTGTTTGGGAGTGCGGGATTCAAAGGTGGTCCCACGGCT
GCCCCTACTGCAAATGGCAGTTTTAATCTTATCTTTTGGCTTCTGCAGATGGTTGCAATTGATCCTTAACCAATAATGGTCAGTCCTCAT
CTCTGTCGTGCTTCATAGGTGCCACCTTGTGTGTTTAAAGAAGGGAAGCTTTGTACCTTTAGAGTGTAGGTGAAATGAATGAATGGCTTG
GAGTGCACTGAGAACAGCATATGATTTCTTGCTTTGGGGAAAAAGAATGATGCTATGAAATTGGTGGGTGGTGTATTTGAGAAGATAATC
ATTGCTTATGTCAAATGGAGCTGAATTTGATAAAAACCCAAAATACAGCTATGAAGTGCTGGGCAAGTTTACTTTTTTTCTGATGTTTCC

>In-frame_ENST00000264057_ENST00000609767_TCGA-BR-8284-01A_DGKD_chr2_234299129_+_UGT1A1_chr2_234675680_length(amino acids)=361AA_start in transcript=12_stop in transcript=1097
MAAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKS
IIFDEVDLTDASVAESSTKNVNNSFTEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILV
KWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMR
LSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKT

--------------------------------------------------------------
>In-frame_ENST00000264057_ENST00000360418_TCGA-BR-8284-01A_DGKD_chr2_234299129_+_UGT1A1_chr2_234675680_length(transcript)=2885nt_BP=360nt
TGGCCCGGCAGCATGGCGGCGGCGGCGGGCGCCCCTCCGCCGGGTCCCCCGCAACCGCCTCCGCCGCCGCCGCCCGAGGAGTCGTCCGAC
AGCGAGCCCGAGGCGGAGCCCGGCTCCCCACAGAAGCTCATCCGCAAGGTGTCCACGTCGGGTCAGATCCGACAGAAGACCATCATCAAA
GAGGGGATGCTGACCAAACAGAACAATTCATTCCAGCGATCAAAAAGGAGATACTTTAAGCTTCGAGGGCGAACGCTTTACTATGCCAAA
ACGGCAAAGTCAATCATATTTGATGAGGTGGATCTGACAGATGCCAGCGTAGCTGAATCCAGTACCAAAAACGTCAACAACAGTTTTACG
GAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAA
GCTATGGCAATTGCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCGAATCTTGCGAACAAC
ACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTT
TATGAAAGCATATGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGCATGGAGACTAAGGGA
GCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGAAAGAAGCAG
CAGTCAGGAAGACAGATGTGAAGAGCTGGAGCATGTTCAGATGAGAGGAGACGGAACACGGGGACACACCAGCTTGAGCAAGGGACAACA
GGGGAGGACTGATGACTGACTTCCCACCTTTGAGGTGCTAATGTGTGTGTGGTGGCACTGGATAAAAGATCAATGTTGGCTAGGCACCAT
GGCACACGCCTGTAGTCCCAGCCACTCTGGAGGCTAAGGCGGGAGGATTGCTTGAGCCCAGAAGTTGGAGGCTGCTATGAGCCGTGATCA
TGCCACTGCACTCCAGCAACCTGGGCAACAGAGTGAGACCCTGTCTCAAAAAAAAAAAAAAAAATGAAAAGTCCACATAACCTGAGCATC
ATGTGCCCAGAGCGTTGGGTGGTGTGGTCCCATTCCTTCCTTCCAGCGGCTTCTTCTGGCCACCTCAATGTCAGGATGTCCTGCTCACAT
ATCAATACCATTAAAACCTGACTTCTTTCCCTGCACTGTTGAAGCTCCTTCTTGAGGCTCACATTATGGATATAATTTTGATTCTTTCTT
CAGTGGTATAGATAACTACTTGTAACCTAAGAACAACTTGGTGAAAGTCCTCTAATACATTATTTTTTAAAAAAACACAAATCAATGAGC
TCAACTTATTAACTAACTTTCATCTATTCATTTTTGAGCCATCCCTGTCTGATTGTGAATCTCCATGATTCCAACACTCTGAGCTGGGGA
TAGTGCCTACACAAAATAAAAAGAAGTGGAAAATTTTCAAACATCAGTTTATGCTGACAACCAGGCCATAATAGGTGCTCAATTACTATT
GAATGAATGAATGAAAGTTCTGGCCAGGTACGGTGGCTCATGCCTGTAGTCCCAACACTTTGGGAGGCCGAGGCAGGTGGATCACTTGAG
GTTAGGAGTTCGAAACCAACCTGACCAACATGAAGAAACCTTATCTCTACCAAAAAAATATAAAAAAATTACCCAGGCATGGTGGTGTAT
GCCTGTAATCCCAGCTATTTGGGAGGCTGAGGCAGGAAAATCACTTGAACCTGAGAGGCGGAGGTTGCAGTGAGCTGAGATTGTGCCACT
CCACTCCAGCCTGGGCGACAGAGTGAGACTCCGTCTTACTTAAAAAAAAAAAAAAGAAGGTTCCAAGAAAATTCATCTTAAGGTTTATGT
AAAAGGAAGATGATATTTAACATGATTCATGGCCAAGTACTAATATTACATTATAATAATGTTTCCAAATAACATTATAGATATGTTTAA
AGACAGTGTATTAGGCTGTTCTTGCATTGCTGTAAAGAAATACCCAAGACTGGGTAATTTATAAAGAAAAGAGGTTTCATTGGCTCGTGT
TTCTGCAGGCTGTACAGGAAGCTTAGTGCTGACATCACTTGGCTGCCGGGGGAACCTCAGGGAGCTTTTACTCATGGCAGAAGGCAATGC
GGGAGCTTGCATGTCACATGGCAAAAGCAGGAGCGAGAGAGAGTTGGGGGGGAAGGTGCCACACACTTTTTAATGACCGGCTCTCACAAT
AACTCATGAAAACTCACTATCAGGAAGACAGCACTAAAGCACAAGGGATCCGACCCCATGATCCAAACACCTCCCACCAGGCCCCATCTC
CAGCACTGGGGATTACAATTCAACATGAGATCTGAGTGTGGACAAATATCCAAACTGTATCAGTCAACAGCGATCATAATTAGTCCTGAA
TAGGAGTGCCTTTTTTTTTCTTTCTTCTCCCTTTTCTTTTCTACTTCCTCCTCCTTTTCCCTCTCCTCTTCAATCTCCTCTTCATTCCTG
TAGCACCAAGGGTTGAAGCACCTAACCCGTTTTGGATTGAGATGTTCTGATTGGGCAATGAACACTGTCCAGAATAAACAGAAATCCATT
TTGCACTAAGTGGCTGCACAGACCCTGCCTCATGCTAAATCTAGCACCCAGATAGTTTAATGTTTCAATGACTGAATTACAAATATATCA
TCACCTTGGATTTGGCACTTACAAATGGCTGTTAATTTGGCCAGAGGTGGTTGTTTACAACTTCAAATAGGAGACTATTCATAATTTCTG

>In-frame_ENST00000264057_ENST00000360418_TCGA-BR-8284-01A_DGKD_chr2_234299129_+_UGT1A1_chr2_234675680_length(amino acids)=272AA_start in transcript=12_stop in transcript=830
MAAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKS
IIFDEVDLTDASVAESSTKNVNNSFTEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILV
KWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKRKKQQSGR

--------------------------------------------------------------
>In-frame_ENST00000264057_ENST00000608383_TCGA-BR-8284-01A_DGKD_chr2_234299129_+_UGT1A1_chr2_234675680_length(transcript)=1098nt_BP=360nt
TGGCCCGGCAGCATGGCGGCGGCGGCGGGCGCCCCTCCGCCGGGTCCCCCGCAACCGCCTCCGCCGCCGCCGCCCGAGGAGTCGTCCGAC
AGCGAGCCCGAGGCGGAGCCCGGCTCCCCACAGAAGCTCATCCGCAAGGTGTCCACGTCGGGTCAGATCCGACAGAAGACCATCATCAAA
GAGGGGATGCTGACCAAACAGAACAATTCATTCCAGCGATCAAAAAGGAGATACTTTAAGCTTCGAGGGCGAACGCTTTACTATGCCAAA
ACGGCAAAGTCAATCATATTTGATGAGGTGGATCTGACAGATGCCAGCGTAGCTGAATCCAGTACCAAAAACGTCAACAACAGTTTTACG
GAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAA
GCTATGGCAATTGCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCGAATCTTGCGAACAAC
ACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTT
TATGAAAGCATATGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGCATGGAGACTAAGGGA
GCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAG
AACATCATGCGCCTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAGTTTGTGATGAGGCAC
AAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGGTACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTC
GTGCTGACAGTGGCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGAGTTAAGAAAGCCCAC

>In-frame_ENST00000264057_ENST00000608383_TCGA-BR-8284-01A_DGKD_chr2_234299129_+_UGT1A1_chr2_234675680_length(amino acids)=361AA_start in transcript=12_stop in transcript=1097
MAAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKS
IIFDEVDLTDASVAESSTKNVNNSFTEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILV
KWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMR
LSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKT

--------------------------------------------------------------
>In-frame_ENST00000409813_ENST00000373450_TCGA-BR-8284-01A_DGKD_chr2_234299129_+_UGT1A1_chr2_234675680_length(transcript)=1784nt_BP=295nt
AGAGACACGAATATGTTTCAGCCGCAACAGGCTGCGTTTCAGCCGGAAGAGTGAAAGGGCACCTTGAAAACGCAAGTTTATGAATATGTT
TCTGTACTTTCAGACCATCATCAAAGAGGGGATGCTGACCAAACAGAACAATTCATTCCAGCGATCAAAAAGGAGATACTTTAAGCTTCG
AGGGCGAACGCTTTACTATGCCAAAACGGCAAAGTCAATCATATTTGATGAGGTGGATCTGACAGATGCCAGCGTAGCTGAATCCAGTAC
CAAAAACGTCAACAACAGTTTTACGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTGGTTTTCTCTTTGGGATCAAT
GGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAAC
CCGACCATCGAATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCACCCGATGACCCGTGCCTTTAT
CACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAA
TGCAAAGCGCATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTAGAAAATGCTCTAAAAGCAGT
CATCAATGACAAAAGTTACAAGGAGAACATCATGCGCCTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTT
CTGGGTGGAGTTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGGTACCAGTACCATTCCTTGGA
CGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTGGCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAA
AAAAGGGCGAGTTAAGAAAGCCCACAAATCCAAGACCCATTGAGAAGTGGGTGGGAAATAAGGTAAAATTTTGAACCATTCCCTAGTCAT
TTCCAAACTTGAAAACAGAATCAGTGTTAAATTCATTTTATTCTTATTAAGGAAATACTTTGCATAAATTAATCAGCCCCAGAGTGCTTT
AAAAAATTCTCTTAAATAAAAATAATAGACTCGCTAGTCAGTAAAGATATTTGAATATGTATCGTGCCCCCTCTGGTGTCTTTGATCAGG
ATGACATGTGCCATTTTTCAGAGGACGTGCAGACAGGCTGGCATTCTAGATTACTTTTCTTACTCTGAAACATGGCCTGTTTGGGAGTGC
GGGATTCAAAGGTGGTCCCACGGCTGCCCCTACTGCAAATGGCAGTTTTAATCTTATCTTTTGGCTTCTGCAGATGGTTGCAATTGATCC
TTAACCAATAATGGTCAGTCCTCATCTCTGTCGTGCTTCATAGGTGCCACCTTGTGTGTTTAAAGAAGGGAAGCTTTGTACCTTTAGAGT
GTAGGTGAAATGAATGAATGGCTTGGAGTGCACTGAGAACAGCATATGATTTCTTGCTTTGGGGAAAAAGAATGATGCTATGAAATTGGT
GGGTGGTGTATTTGAGAAGATAATCATTGCTTATGTCAAATGGAGCTGAATTTGATAAAAACCCAAAATACAGCTATGAAGTGCTGGGCA

>In-frame_ENST00000409813_ENST00000373450_TCGA-BR-8284-01A_DGKD_chr2_234299129_+_UGT1A1_chr2_234675680_length(amino acids)=317AA_start in transcript=79_stop in transcript=1032
MNMFLYFQTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNVNNSFTEFEAYINASGEHGIVVFS
LGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGD
QMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQY

--------------------------------------------------------------
>In-frame_ENST00000409813_ENST00000609637_TCGA-BR-8284-01A_DGKD_chr2_234299129_+_UGT1A1_chr2_234675680_length(transcript)=1777nt_BP=295nt
AGAGACACGAATATGTTTCAGCCGCAACAGGCTGCGTTTCAGCCGGAAGAGTGAAAGGGCACCTTGAAAACGCAAGTTTATGAATATGTT
TCTGTACTTTCAGACCATCATCAAAGAGGGGATGCTGACCAAACAGAACAATTCATTCCAGCGATCAAAAAGGAGATACTTTAAGCTTCG
AGGGCGAACGCTTTACTATGCCAAAACGGCAAAGTCAATCATATTTGATGAGGTGGATCTGACAGATGCCAGCGTAGCTGAATCCAGTAC
CAAAAACGTCAACAACAGTTTTACGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTGGTTTTCTCTTTGGGATCAAT
GGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAAC
CCGACCATCGAATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCACCCGATGACCCGTGCCTTTAT
CACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAA
TGCAAAGCGCATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTAGAAAATGCTCTAAAAGCAGT
CATCAATGACAAAAGTTACAAGGAGAACATCATGCGCCTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTT
CTGGGTGGAGTTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGGTACCAGTACCATTCCTTGGA
CGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTGGCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAA
AAAAGGGCGAGTTAAGAAAGCCCACAAATCCAAGACCCATTGAGAAGTGGGTGGGAAATAAGGTAAAATTTTGAACCATTCCCTAGTCAT
TTCCAAACTTGAAAACAGAATCAGTGTTAAATTCATTTTATTCTTATTAAGGAAATACTTTGCATAAATTAATCAGCCCCAGAGTGCTTT
AAAAAATTCTCTTAAATAAAAATAATAGACTCGCTAGTCAGTAAAGATATTTGAATATGTATCGTGCCCCCTCTGGTGTCTTTGATCAGG
ATGACATGTGCCATTTTTCAGAGGACGTGCAGACAGGCTGGCATTCTAGATTACTTTTCTTACTCTGAAACATGGCCTGTTTGGGAGTGC
GGGATTCAAAGGTGGTCCCACGGCTGCCCCTACTGCAAATGGCAGTTTTAATCTTATCTTTTGGCTTCTGCAGATGGTTGCAATTGATCC
TTAACCAATAATGGTCAGTCCTCATCTCTGTCGTGCTTCATAGGTGCCACCTTGTGTGTTTAAAGAAGGGAAGCTTTGTACCTTTAGAGT
GTAGGTGAAATGAATGAATGGCTTGGAGTGCACTGAGAACAGCATATGATTTCTTGCTTTGGGGAAAAAGAATGATGCTATGAAATTGGT
GGGTGGTGTATTTGAGAAGATAATCATTGCTTATGTCAAATGGAGCTGAATTTGATAAAAACCCAAAATACAGCTATGAAGTGCTGGGCA

>In-frame_ENST00000409813_ENST00000609637_TCGA-BR-8284-01A_DGKD_chr2_234299129_+_UGT1A1_chr2_234675680_length(amino acids)=317AA_start in transcript=79_stop in transcript=1032
MNMFLYFQTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNVNNSFTEFEAYINASGEHGIVVFS
LGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGD
QMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQY

--------------------------------------------------------------
>In-frame_ENST00000409813_ENST00000608381_TCGA-BR-8284-01A_DGKD_chr2_234299129_+_UGT1A1_chr2_234675680_length(transcript)=1773nt_BP=295nt
AGAGACACGAATATGTTTCAGCCGCAACAGGCTGCGTTTCAGCCGGAAGAGTGAAAGGGCACCTTGAAAACGCAAGTTTATGAATATGTT
TCTGTACTTTCAGACCATCATCAAAGAGGGGATGCTGACCAAACAGAACAATTCATTCCAGCGATCAAAAAGGAGATACTTTAAGCTTCG
AGGGCGAACGCTTTACTATGCCAAAACGGCAAAGTCAATCATATTTGATGAGGTGGATCTGACAGATGCCAGCGTAGCTGAATCCAGTAC
CAAAAACGTCAACAACAGTTTTACGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTGGTTTTCTCTTTGGGATCAAT
GGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAAC
CCGACCATCGAATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCACCCGATGACCCGTGCCTTTAT
CACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAA
TGCAAAGCGCATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTAGAAAATGCTCTAAAAGCAGT
CATCAATGACAAAAGTTACAAGGAGAACATCATGCGCCTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTT
CTGGGTGGAGTTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGGTACCAGTACCATTCCTTGGA
CGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTGGCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAA
AAAAGGGCGAGTTAAGAAAGCCCACAAATCCAAGACCCATTGAGAAGTGGGTGGGAAATAAGGTAAAATTTTGAACCATTCCCTAGTCAT
TTCCAAACTTGAAAACAGAATCAGTGTTAAATTCATTTTATTCTTATTAAGGAAATACTTTGCATAAATTAATCAGCCCCAGAGTGCTTT
AAAAAATTCTCTTAAATAAAAATAATAGACTCGCTAGTCAGTAAAGATATTTGAATATGTATCGTGCCCCCTCTGGTGTCTTTGATCAGG
ATGACATGTGCCATTTTTCAGAGGACGTGCAGACAGGCTGGCATTCTAGATTACTTTTCTTACTCTGAAACATGGCCTGTTTGGGAGTGC
GGGATTCAAAGGTGGTCCCACGGCTGCCCCTACTGCAAATGGCAGTTTTAATCTTATCTTTTGGCTTCTGCAGATGGTTGCAATTGATCC
TTAACCAATAATGGTCAGTCCTCATCTCTGTCGTGCTTCATAGGTGCCACCTTGTGTGTTTAAAGAAGGGAAGCTTTGTACCTTTAGAGT
GTAGGTGAAATGAATGAATGGCTTGGAGTGCACTGAGAACAGCATATGATTTCTTGCTTTGGGGAAAAAGAATGATGCTATGAAATTGGT
GGGTGGTGTATTTGAGAAGATAATCATTGCTTATGTCAAATGGAGCTGAATTTGATAAAAACCCAAAATACAGCTATGAAGTGCTGGGCA

>In-frame_ENST00000409813_ENST00000608381_TCGA-BR-8284-01A_DGKD_chr2_234299129_+_UGT1A1_chr2_234675680_length(amino acids)=317AA_start in transcript=79_stop in transcript=1032
MNMFLYFQTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNVNNSFTEFEAYINASGEHGIVVFS
LGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGD
QMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQY

--------------------------------------------------------------
>In-frame_ENST00000409813_ENST00000609767_TCGA-BR-8284-01A_DGKD_chr2_234299129_+_UGT1A1_chr2_234675680_length(transcript)=1777nt_BP=295nt
AGAGACACGAATATGTTTCAGCCGCAACAGGCTGCGTTTCAGCCGGAAGAGTGAAAGGGCACCTTGAAAACGCAAGTTTATGAATATGTT
TCTGTACTTTCAGACCATCATCAAAGAGGGGATGCTGACCAAACAGAACAATTCATTCCAGCGATCAAAAAGGAGATACTTTAAGCTTCG
AGGGCGAACGCTTTACTATGCCAAAACGGCAAAGTCAATCATATTTGATGAGGTGGATCTGACAGATGCCAGCGTAGCTGAATCCAGTAC
CAAAAACGTCAACAACAGTTTTACGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTGGTTTTCTCTTTGGGATCAAT
GGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAAC
CCGACCATCGAATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCACCCGATGACCCGTGCCTTTAT
CACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAA
TGCAAAGCGCATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTAGAAAATGCTCTAAAAGCAGT
CATCAATGACAAAAGTTACAAGGAGAACATCATGCGCCTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTT
CTGGGTGGAGTTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGGTACCAGTACCATTCCTTGGA
CGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTGGCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAA
AAAAGGGCGAGTTAAGAAAGCCCACAAATCCAAGACCCATTGAGAAGTGGGTGGGAAATAAGGTAAAATTTTGAACCATTCCCTAGTCAT
TTCCAAACTTGAAAACAGAATCAGTGTTAAATTCATTTTATTCTTATTAAGGAAATACTTTGCATAAATTAATCAGCCCCAGAGTGCTTT
AAAAAATTCTCTTAAATAAAAATAATAGACTCGCTAGTCAGTAAAGATATTTGAATATGTATCGTGCCCCCTCTGGTGTCTTTGATCAGG
ATGACATGTGCCATTTTTCAGAGGACGTGCAGACAGGCTGGCATTCTAGATTACTTTTCTTACTCTGAAACATGGCCTGTTTGGGAGTGC
GGGATTCAAAGGTGGTCCCACGGCTGCCCCTACTGCAAATGGCAGTTTTAATCTTATCTTTTGGCTTCTGCAGATGGTTGCAATTGATCC
TTAACCAATAATGGTCAGTCCTCATCTCTGTCGTGCTTCATAGGTGCCACCTTGTGTGTTTAAAGAAGGGAAGCTTTGTACCTTTAGAGT
GTAGGTGAAATGAATGAATGGCTTGGAGTGCACTGAGAACAGCATATGATTTCTTGCTTTGGGGAAAAAGAATGATGCTATGAAATTGGT
GGGTGGTGTATTTGAGAAGATAATCATTGCTTATGTCAAATGGAGCTGAATTTGATAAAAACCCAAAATACAGCTATGAAGTGCTGGGCA

>In-frame_ENST00000409813_ENST00000609767_TCGA-BR-8284-01A_DGKD_chr2_234299129_+_UGT1A1_chr2_234675680_length(amino acids)=317AA_start in transcript=79_stop in transcript=1032
MNMFLYFQTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNVNNSFTEFEAYINASGEHGIVVFS
LGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGD
QMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQY

--------------------------------------------------------------
>In-frame_ENST00000409813_ENST00000360418_TCGA-BR-8284-01A_DGKD_chr2_234299129_+_UGT1A1_chr2_234675680_length(transcript)=2820nt_BP=295nt
AGAGACACGAATATGTTTCAGCCGCAACAGGCTGCGTTTCAGCCGGAAGAGTGAAAGGGCACCTTGAAAACGCAAGTTTATGAATATGTT
TCTGTACTTTCAGACCATCATCAAAGAGGGGATGCTGACCAAACAGAACAATTCATTCCAGCGATCAAAAAGGAGATACTTTAAGCTTCG
AGGGCGAACGCTTTACTATGCCAAAACGGCAAAGTCAATCATATTTGATGAGGTGGATCTGACAGATGCCAGCGTAGCTGAATCCAGTAC
CAAAAACGTCAACAACAGTTTTACGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTGGTTTTCTCTTTGGGATCAAT
GGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAAC
CCGACCATCGAATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCACCCGATGACCCGTGCCTTTAT
CACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAA
TGCAAAGCGCATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTAGAAAATGCTCTAAAAGCAGT
CATCAATGACAAAAGAAAGAAGCAGCAGTCAGGAAGACAGATGTGAAGAGCTGGAGCATGTTCAGATGAGAGGAGACGGAACACGGGGAC
ACACCAGCTTGAGCAAGGGACAACAGGGGAGGACTGATGACTGACTTCCCACCTTTGAGGTGCTAATGTGTGTGTGGTGGCACTGGATAA
AAGATCAATGTTGGCTAGGCACCATGGCACACGCCTGTAGTCCCAGCCACTCTGGAGGCTAAGGCGGGAGGATTGCTTGAGCCCAGAAGT
TGGAGGCTGCTATGAGCCGTGATCATGCCACTGCACTCCAGCAACCTGGGCAACAGAGTGAGACCCTGTCTCAAAAAAAAAAAAAAAAAT
GAAAAGTCCACATAACCTGAGCATCATGTGCCCAGAGCGTTGGGTGGTGTGGTCCCATTCCTTCCTTCCAGCGGCTTCTTCTGGCCACCT
CAATGTCAGGATGTCCTGCTCACATATCAATACCATTAAAACCTGACTTCTTTCCCTGCACTGTTGAAGCTCCTTCTTGAGGCTCACATT
ATGGATATAATTTTGATTCTTTCTTCAGTGGTATAGATAACTACTTGTAACCTAAGAACAACTTGGTGAAAGTCCTCTAATACATTATTT
TTTAAAAAAACACAAATCAATGAGCTCAACTTATTAACTAACTTTCATCTATTCATTTTTGAGCCATCCCTGTCTGATTGTGAATCTCCA
TGATTCCAACACTCTGAGCTGGGGATAGTGCCTACACAAAATAAAAAGAAGTGGAAAATTTTCAAACATCAGTTTATGCTGACAACCAGG
CCATAATAGGTGCTCAATTACTATTGAATGAATGAATGAAAGTTCTGGCCAGGTACGGTGGCTCATGCCTGTAGTCCCAACACTTTGGGA
GGCCGAGGCAGGTGGATCACTTGAGGTTAGGAGTTCGAAACCAACCTGACCAACATGAAGAAACCTTATCTCTACCAAAAAAATATAAAA
AAATTACCCAGGCATGGTGGTGTATGCCTGTAATCCCAGCTATTTGGGAGGCTGAGGCAGGAAAATCACTTGAACCTGAGAGGCGGAGGT
TGCAGTGAGCTGAGATTGTGCCACTCCACTCCAGCCTGGGCGACAGAGTGAGACTCCGTCTTACTTAAAAAAAAAAAAAAGAAGGTTCCA
AGAAAATTCATCTTAAGGTTTATGTAAAAGGAAGATGATATTTAACATGATTCATGGCCAAGTACTAATATTACATTATAATAATGTTTC
CAAATAACATTATAGATATGTTTAAAGACAGTGTATTAGGCTGTTCTTGCATTGCTGTAAAGAAATACCCAAGACTGGGTAATTTATAAA
GAAAAGAGGTTTCATTGGCTCGTGTTTCTGCAGGCTGTACAGGAAGCTTAGTGCTGACATCACTTGGCTGCCGGGGGAACCTCAGGGAGC
TTTTACTCATGGCAGAAGGCAATGCGGGAGCTTGCATGTCACATGGCAAAAGCAGGAGCGAGAGAGAGTTGGGGGGGAAGGTGCCACACA
CTTTTTAATGACCGGCTCTCACAATAACTCATGAAAACTCACTATCAGGAAGACAGCACTAAAGCACAAGGGATCCGACCCCATGATCCA
AACACCTCCCACCAGGCCCCATCTCCAGCACTGGGGATTACAATTCAACATGAGATCTGAGTGTGGACAAATATCCAAACTGTATCAGTC
AACAGCGATCATAATTAGTCCTGAATAGGAGTGCCTTTTTTTTTCTTTCTTCTCCCTTTTCTTTTCTACTTCCTCCTCCTTTTCCCTCTC
CTCTTCAATCTCCTCTTCATTCCTGTAGCACCAAGGGTTGAAGCACCTAACCCGTTTTGGATTGAGATGTTCTGATTGGGCAATGAACAC
TGTCCAGAATAAACAGAAATCCATTTTGCACTAAGTGGCTGCACAGACCCTGCCTCATGCTAAATCTAGCACCCAGATAGTTTAATGTTT
CAATGACTGAATTACAAATATATCATCACCTTGGATTTGGCACTTACAAATGGCTGTTAATTTGGCCAGAGGTGGTTGTTTACAACTTCA

>In-frame_ENST00000409813_ENST00000360418_TCGA-BR-8284-01A_DGKD_chr2_234299129_+_UGT1A1_chr2_234675680_length(amino acids)=228AA_start in transcript=79_stop in transcript=765
MNMFLYFQTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNVNNSFTEFEAYINASGEHGIVVFS
LGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGD

--------------------------------------------------------------
>In-frame_ENST00000409813_ENST00000608383_TCGA-BR-8284-01A_DGKD_chr2_234299129_+_UGT1A1_chr2_234675680_length(transcript)=1033nt_BP=295nt
AGAGACACGAATATGTTTCAGCCGCAACAGGCTGCGTTTCAGCCGGAAGAGTGAAAGGGCACCTTGAAAACGCAAGTTTATGAATATGTT
TCTGTACTTTCAGACCATCATCAAAGAGGGGATGCTGACCAAACAGAACAATTCATTCCAGCGATCAAAAAGGAGATACTTTAAGCTTCG
AGGGCGAACGCTTTACTATGCCAAAACGGCAAAGTCAATCATATTTGATGAGGTGGATCTGACAGATGCCAGCGTAGCTGAATCCAGTAC
CAAAAACGTCAACAACAGTTTTACGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTGGTTTTCTCTTTGGGATCAAT
GGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAAC
CCGACCATCGAATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCACCCGATGACCCGTGCCTTTAT
CACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAA
TGCAAAGCGCATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTAGAAAATGCTCTAAAAGCAGT
CATCAATGACAAAAGTTACAAGGAGAACATCATGCGCCTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTT
CTGGGTGGAGTTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGGTACCAGTACCATTCCTTGGA
CGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTGGCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAA

>In-frame_ENST00000409813_ENST00000608383_TCGA-BR-8284-01A_DGKD_chr2_234299129_+_UGT1A1_chr2_234675680_length(amino acids)=318AA_start in transcript=79_stop in transcript=1032
MNMFLYFQTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNVNNSFTEFEAYINASGEHGIVVFS
LGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGD
QMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DGKD-UGT1A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DGKD-UGT1A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DGKD-UGT1A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDGKDC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneUGT1A1C2931132Crigler Najjar syndrome, type 219CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneUGT1A1C0010324Crigler Najjar syndrome, type 115CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneUGT1A1C0017551Gilbert Disease (disorder)8CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneUGT1A1C0020433Hyperbilirubinemia5CTD_human
TgeneUGT1A1C0022610Kernicterus2CTD_human
TgeneUGT1A1C0270210Lucey-Driscoll syndrome (disorder)2CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneUGT1A1C0011616Contact Dermatitis1CTD_human
TgeneUGT1A1C0013221Drug toxicity1CTD_human
TgeneUGT1A1C0019829Hodgkin Disease1CTD_human
TgeneUGT1A1C0022660Kidney Failure, Acute1CTD_human
TgeneUGT1A1C0027947Neutropenia1CTD_human
TgeneUGT1A1C0041755Adverse reaction to drug1CTD_human
TgeneUGT1A1C0152266Mixed Cellularity Hodgkin Lymphoma1CTD_human
TgeneUGT1A1C0152267Hodgkin lymphoma, lymphocyte depletion1CTD_human
TgeneUGT1A1C0162351Contact hypersensitivity1CTD_human
TgeneUGT1A1C0220597Adult Hodgkin Lymphoma1CTD_human
TgeneUGT1A1C0262584Carcinoma, Small Cell1CTD_human
TgeneUGT1A1C0857007Hyperbilirubinemia, Neonatal1CTD_human
TgeneUGT1A1C1266194Lymphocyte Rich Classical Hodgkin Lymphoma1CTD_human
TgeneUGT1A1C1334968Nodular Lymphocyte Predominant Hodgkin Lymphoma1CTD_human
TgeneUGT1A1C1565662Acute Kidney Insufficiency1CTD_human
TgeneUGT1A1C1565885Direct Hyperbilirubinemia, Neonatal1CTD_human
TgeneUGT1A1C1565886Indirect Hyperbilirubinemia, Neonatal1CTD_human
TgeneUGT1A1C2609414Acute kidney injury1CTD_human