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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:DGKD-UGT1A3 (FusionGDB2 ID:22445) |
Fusion Gene Summary for DGKD-UGT1A3 |
Fusion gene summary |
Fusion gene information | Fusion gene name: DGKD-UGT1A3 | Fusion gene ID: 22445 | Hgene | Tgene | Gene symbol | DGKD | UGT1A3 | Gene ID | 8527 | 54659 |
Gene name | diacylglycerol kinase delta | UDP glucuronosyltransferase family 1 member A3 | |
Synonyms | DGK-delta|DGKdelta|dgkd-2 | UDPGT|UDPGT 1-3|UGT-1C|UGT1-03|UGT1.3|UGT1A3S|UGT1C | |
Cytomap | 2q37.1 | 2q37.1 | |
Type of gene | protein-coding | protein-coding | |
Description | diacylglycerol kinase deltaDAG kinase deltadiacylglycerol kinase, delta 130kDadiglyceride kinase delta | UDP-glucuronosyltransferase 1-3UDP glucuronosyltransferase 1 family, polypeptide A3UDP glycosyltransferase 1 family, polypeptide A3UDP-glucuronosyltransferase 1 family polypeptide A3sUDP-glucuronosyltransferase 1-CUDP-glucuronosyltransferase 1A3UGT1 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q16760 | . | |
Ensembl transtripts involved in fusion gene | ENST00000264057, ENST00000409813, ENST00000489613, | ENST00000482026, | |
Fusion gene scores | * DoF score | 21 X 6 X 10=1260 | 5 X 1 X 6=30 |
# samples | 23 | 6 | |
** MAII score | log2(23/1260*10)=-2.4537179674429 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/30*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: DGKD [Title/Abstract] AND UGT1A3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | DGKD(234263320)-UGT1A3(234675680), # samples:1 DGKD(234299129)-UGT1A3(234675680), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DGKD | GO:0010033 | response to organic substance | 12200442 |
Tgene | UGT1A3 | GO:0052695 | cellular glucuronidation | 17179145|22579593 |
Tgene | UGT1A3 | GO:0052696 | flavonoid glucuronidation | 20056724 |
Tgene | UGT1A3 | GO:0052697 | xenobiotic glucuronidation | 20056724 |
Fusion gene breakpoints across DGKD (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across UGT1A3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | LUAD | TCGA-91-6836-01A | DGKD | chr2 | 234263320 | + | UGT1A3 | chr2 | 234675680 | + |
ChimerDB4 | STAD | TCGA-BR-8284-01A | DGKD | chr2 | 234299129 | + | UGT1A3 | chr2 | 234675680 | + |
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Fusion Gene ORF analysis for DGKD-UGT1A3 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000264057 | ENST00000482026 | DGKD | chr2 | 234263320 | + | UGT1A3 | chr2 | 234675680 | + |
intron-3CDS | ENST00000409813 | ENST00000482026 | DGKD | chr2 | 234263320 | + | UGT1A3 | chr2 | 234675680 | + |
intron-3CDS | ENST00000489613 | ENST00000482026 | DGKD | chr2 | 234263320 | + | UGT1A3 | chr2 | 234675680 | + |
In-frame | ENST00000264057 | ENST00000482026 | DGKD | chr2 | 234299129 | + | UGT1A3 | chr2 | 234675680 | + |
In-frame | ENST00000409813 | ENST00000482026 | DGKD | chr2 | 234299129 | + | UGT1A3 | chr2 | 234675680 | + |
intron-3CDS | ENST00000489613 | ENST00000482026 | DGKD | chr2 | 234299129 | + | UGT1A3 | chr2 | 234675680 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000264057 | DGKD | chr2 | 234263320 | + | ENST00000482026 | UGT1A3 | chr2 | 234675680 | + | 1646 | 168 | 12 | 905 | 297 |
ENST00000264057 | DGKD | chr2 | 234299129 | + | ENST00000482026 | UGT1A3 | chr2 | 234675680 | + | 1838 | 360 | 12 | 1097 | 361 |
ENST00000409813 | DGKD | chr2 | 234299129 | + | ENST00000482026 | UGT1A3 | chr2 | 234675680 | + | 1773 | 295 | 79 | 1032 | 317 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000264057 | ENST00000482026 | DGKD | chr2 | 234263320 | + | UGT1A3 | chr2 | 234675680 | + | 0.001209681 | 0.9987903 |
ENST00000264057 | ENST00000482026 | DGKD | chr2 | 234299129 | + | UGT1A3 | chr2 | 234675680 | + | 0.000337005 | 0.999663 |
ENST00000409813 | ENST00000482026 | DGKD | chr2 | 234299129 | + | UGT1A3 | chr2 | 234675680 | + | 0.000530974 | 0.999469 |
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Fusion Genomic Features for DGKD-UGT1A3 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
DGKD | chr2 | 234263320 | + | UGT1A3 | chr2 | 234675679 | + | 6.18E-06 | 0.9999938 |
DGKD | chr2 | 234299129 | + | UGT1A3 | chr2 | 234675679 | + | 2.24E-09 | 1 |
DGKD | chr2 | 234263320 | + | UGT1A3 | chr2 | 234675679 | + | 6.18E-06 | 0.9999938 |
DGKD | chr2 | 234299129 | + | UGT1A3 | chr2 | 234675679 | + | 2.24E-09 | 1 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for DGKD-UGT1A3 |
Go to FGviewer for the breakpoints of chr2:234263320-chr2:234675680 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
DGKD | . |
FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12200442, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development (By similarity). May also regulate clathrin-dependent endocytosis (PubMed:17880279). {ECO:0000250|UniProtKB:E9PUQ8, ECO:0000269|PubMed:12200442, ECO:0000269|PubMed:17880279, ECO:0000269|PubMed:23949095, ECO:0000305}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | DGKD | chr2:234263320 | chr2:234675680 | ENST00000264057 | + | 1 | 30 | 8_36 | 52.0 | 1215.0 | Compositional bias | Note=Pro-rich |
Hgene | DGKD | chr2:234299129 | chr2:234675680 | ENST00000264057 | + | 3 | 30 | 8_36 | 116.0 | 1215.0 | Compositional bias | Note=Pro-rich |
Hgene | DGKD | chr2:234299129 | chr2:234675680 | ENST00000409813 | + | 2 | 29 | 8_36 | 72.0 | 1171.0 | Compositional bias | Note=Pro-rich |
Tgene | UGT1A3 | chr2:234263320 | chr2:234675680 | ENST00000482026 | 0 | 5 | 492_508 | 289.0 | 535.0 | Transmembrane | Helical | |
Tgene | UGT1A3 | chr2:234299129 | chr2:234675680 | ENST00000482026 | 0 | 5 | 492_508 | 289.0 | 535.0 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | DGKD | chr2:234263320 | chr2:234675680 | ENST00000409813 | + | 1 | 29 | 8_36 | 0 | 1171.0 | Compositional bias | Note=Pro-rich |
Hgene | DGKD | chr2:234263320 | chr2:234675680 | ENST00000264057 | + | 1 | 30 | 1145_1208 | 52.0 | 1215.0 | Domain | SAM |
Hgene | DGKD | chr2:234263320 | chr2:234675680 | ENST00000264057 | + | 1 | 30 | 317_451 | 52.0 | 1215.0 | Domain | DAGKc |
Hgene | DGKD | chr2:234263320 | chr2:234675680 | ENST00000264057 | + | 1 | 30 | 53_146 | 52.0 | 1215.0 | Domain | PH |
Hgene | DGKD | chr2:234263320 | chr2:234675680 | ENST00000409813 | + | 1 | 29 | 1145_1208 | 0 | 1171.0 | Domain | SAM |
Hgene | DGKD | chr2:234263320 | chr2:234675680 | ENST00000409813 | + | 1 | 29 | 317_451 | 0 | 1171.0 | Domain | DAGKc |
Hgene | DGKD | chr2:234263320 | chr2:234675680 | ENST00000409813 | + | 1 | 29 | 53_146 | 0 | 1171.0 | Domain | PH |
Hgene | DGKD | chr2:234299129 | chr2:234675680 | ENST00000264057 | + | 3 | 30 | 1145_1208 | 116.0 | 1215.0 | Domain | SAM |
Hgene | DGKD | chr2:234299129 | chr2:234675680 | ENST00000264057 | + | 3 | 30 | 317_451 | 116.0 | 1215.0 | Domain | DAGKc |
Hgene | DGKD | chr2:234299129 | chr2:234675680 | ENST00000264057 | + | 3 | 30 | 53_146 | 116.0 | 1215.0 | Domain | PH |
Hgene | DGKD | chr2:234299129 | chr2:234675680 | ENST00000409813 | + | 2 | 29 | 1145_1208 | 72.0 | 1171.0 | Domain | SAM |
Hgene | DGKD | chr2:234299129 | chr2:234675680 | ENST00000409813 | + | 2 | 29 | 317_451 | 72.0 | 1171.0 | Domain | DAGKc |
Hgene | DGKD | chr2:234299129 | chr2:234675680 | ENST00000409813 | + | 2 | 29 | 53_146 | 72.0 | 1171.0 | Domain | PH |
Hgene | DGKD | chr2:234263320 | chr2:234675680 | ENST00000264057 | + | 1 | 30 | 163_213 | 52.0 | 1215.0 | Zinc finger | Phorbol-ester/DAG-type 1 |
Hgene | DGKD | chr2:234263320 | chr2:234675680 | ENST00000264057 | + | 1 | 30 | 235_286 | 52.0 | 1215.0 | Zinc finger | Phorbol-ester/DAG-type 2 |
Hgene | DGKD | chr2:234263320 | chr2:234675680 | ENST00000409813 | + | 1 | 29 | 163_213 | 0 | 1171.0 | Zinc finger | Phorbol-ester/DAG-type 1 |
Hgene | DGKD | chr2:234263320 | chr2:234675680 | ENST00000409813 | + | 1 | 29 | 235_286 | 0 | 1171.0 | Zinc finger | Phorbol-ester/DAG-type 2 |
Hgene | DGKD | chr2:234299129 | chr2:234675680 | ENST00000264057 | + | 3 | 30 | 163_213 | 116.0 | 1215.0 | Zinc finger | Phorbol-ester/DAG-type 1 |
Hgene | DGKD | chr2:234299129 | chr2:234675680 | ENST00000264057 | + | 3 | 30 | 235_286 | 116.0 | 1215.0 | Zinc finger | Phorbol-ester/DAG-type 2 |
Hgene | DGKD | chr2:234299129 | chr2:234675680 | ENST00000409813 | + | 2 | 29 | 163_213 | 72.0 | 1171.0 | Zinc finger | Phorbol-ester/DAG-type 1 |
Hgene | DGKD | chr2:234299129 | chr2:234675680 | ENST00000409813 | + | 2 | 29 | 235_286 | 72.0 | 1171.0 | Zinc finger | Phorbol-ester/DAG-type 2 |
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Fusion Gene Sequence for DGKD-UGT1A3 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000264057_ENST00000482026_TCGA-91-6836-01A_DGKD_chr2_234263320_+_UGT1A3_chr2_234675680_length(transcript)=1646nt_BP=168nt TGGCCCGGCAGCATGGCGGCGGCGGCGGGCGCCCCTCCGCCGGGTCCCCCGCAACCGCCTCCGCCGCCGCCGCCCGAGGAGTCGTCCGAC AGCGAGCCCGAGGCGGAGCCCGGCTCCCCACAGAAGCTCATCCGCAAGGTGTCCACGTCGGGTCAGATCCGACAGAAGGAATTTGAAGCC TACATTAATGCTTCTGGAGAACATGGAATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATT GCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCGAATCTTGCGAACAACACGATACTTGTT AAGTGGCTACCCCAAAACGATCTGCTTGGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATA TGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGCATGGAGACTAAGGGAGCTGGAGTGACC CTGAATGTTCTGGAAATGACTTCTGAAGATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATCATGCGC CTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAGTTTGTGATGAGGCACAAGGGCGCGCCA CACCTGCGCCCCGCAGCCCACGACCTCACCTGGTACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTG GCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGAGTTAAGAAAGCCCACAAATCCAAGACC CATTGAGAAGTGGGTGGGAAATAAGGTAAAATTTTGAACCATTCCCTAGTCATTTCCAAACTTGAAAACAGAATCAGTGTTAAATTCATT TTATTCTTATTAAGGAAATACTTTGCATAAATTAATCAGCCCCAGAGTGCTTTAAAAAATTCTCTTAAATAAAAATAATAGACTCGCTAG TCAGTAAAGATATTTGAATATGTATCGTGCCCCCTCTGGTGTCTTTGATCAGGATGACATGTGCCATTTTTCAGAGGACGTGCAGACAGG CTGGCATTCTAGATTACTTTTCTTACTCTGAAACATGGCCTGTTTGGGAGTGCGGGATTCAAAGGTGGTCCCACGGCTGCCCCTACTGCA AATGGCAGTTTTAATCTTATCTTTTGGCTTCTGCAGATGGTTGCAATTGATCCTTAACCAATAATGGTCAGTCCTCATCTCTGTCGTGCT TCATAGGTGCCACCTTGTGTGTTTAAAGAAGGGAAGCTTTGTACCTTTAGAGTGTAGGTGAAATGAATGAATGGCTTGGAGTGCACTGAG AACAGCATATGATTTCTTGCTTTGGGGAAAAAGAATGATGCTATGAAATTGGTGGGTGGTGTATTTGAGAAGATAATCATTGCTTATGTC AAATGGAGCTGAATTTGATAAAAACCCAAAATACAGCTATGAAGTGCTGGGCAAGTTTACTTTTTTTCTGATGTTTCCTACAACTAAAAA >In-frame_ENST00000264057_ENST00000482026_TCGA-91-6836-01A_DGKD_chr2_234263320_+_UGT1A3_chr2_234675680_length(amino acids)=297AA_start in transcript=12_stop in transcript=905 MAAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADAL GKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVL EMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFIT -------------------------------------------------------------- >In-frame_ENST00000264057_ENST00000482026_TCGA-BR-8284-01A_DGKD_chr2_234299129_+_UGT1A3_chr2_234675680_length(transcript)=1838nt_BP=360nt TGGCCCGGCAGCATGGCGGCGGCGGCGGGCGCCCCTCCGCCGGGTCCCCCGCAACCGCCTCCGCCGCCGCCGCCCGAGGAGTCGTCCGAC AGCGAGCCCGAGGCGGAGCCCGGCTCCCCACAGAAGCTCATCCGCAAGGTGTCCACGTCGGGTCAGATCCGACAGAAGACCATCATCAAA GAGGGGATGCTGACCAAACAGAACAATTCATTCCAGCGATCAAAAAGGAGATACTTTAAGCTTCGAGGGCGAACGCTTTACTATGCCAAA ACGGCAAAGTCAATCATATTTGATGAGGTGGATCTGACAGATGCCAGCGTAGCTGAATCCAGTACCAAAAACGTCAACAACAGTTTTACG GAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAA GCTATGGCAATTGCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACCCGACCATCGAATCTTGCGAACAAC ACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTT TATGAAAGCATATGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAATGCAAAGCGCATGGAGACTAAGGGA GCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAG AACATCATGCGCCTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTCTGGGTGGAGTTTGTGATGAGGCAC AAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGGTACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTC GTGCTGACAGTGGCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAAAAAGGGCGAGTTAAGAAAGCCCAC AAATCCAAGACCCATTGAGAAGTGGGTGGGAAATAAGGTAAAATTTTGAACCATTCCCTAGTCATTTCCAAACTTGAAAACAGAATCAGT GTTAAATTCATTTTATTCTTATTAAGGAAATACTTTGCATAAATTAATCAGCCCCAGAGTGCTTTAAAAAATTCTCTTAAATAAAAATAA TAGACTCGCTAGTCAGTAAAGATATTTGAATATGTATCGTGCCCCCTCTGGTGTCTTTGATCAGGATGACATGTGCCATTTTTCAGAGGA CGTGCAGACAGGCTGGCATTCTAGATTACTTTTCTTACTCTGAAACATGGCCTGTTTGGGAGTGCGGGATTCAAAGGTGGTCCCACGGCT GCCCCTACTGCAAATGGCAGTTTTAATCTTATCTTTTGGCTTCTGCAGATGGTTGCAATTGATCCTTAACCAATAATGGTCAGTCCTCAT CTCTGTCGTGCTTCATAGGTGCCACCTTGTGTGTTTAAAGAAGGGAAGCTTTGTACCTTTAGAGTGTAGGTGAAATGAATGAATGGCTTG GAGTGCACTGAGAACAGCATATGATTTCTTGCTTTGGGGAAAAAGAATGATGCTATGAAATTGGTGGGTGGTGTATTTGAGAAGATAATC ATTGCTTATGTCAAATGGAGCTGAATTTGATAAAAACCCAAAATACAGCTATGAAGTGCTGGGCAAGTTTACTTTTTTTCTGATGTTTCC >In-frame_ENST00000264057_ENST00000482026_TCGA-BR-8284-01A_DGKD_chr2_234299129_+_UGT1A3_chr2_234675680_length(amino acids)=361AA_start in transcript=12_stop in transcript=1097 MAAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKS IIFDEVDLTDASVAESSTKNVNNSFTEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILV KWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMR LSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKT -------------------------------------------------------------- >In-frame_ENST00000409813_ENST00000482026_TCGA-BR-8284-01A_DGKD_chr2_234299129_+_UGT1A3_chr2_234675680_length(transcript)=1773nt_BP=295nt AGAGACACGAATATGTTTCAGCCGCAACAGGCTGCGTTTCAGCCGGAAGAGTGAAAGGGCACCTTGAAAACGCAAGTTTATGAATATGTT TCTGTACTTTCAGACCATCATCAAAGAGGGGATGCTGACCAAACAGAACAATTCATTCCAGCGATCAAAAAGGAGATACTTTAAGCTTCG AGGGCGAACGCTTTACTATGCCAAAACGGCAAAGTCAATCATATTTGATGAGGTGGATCTGACAGATGCCAGCGTAGCTGAATCCAGTAC CAAAAACGTCAACAACAGTTTTACGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACATGGAATTGTGGTTTTCTCTTTGGGATCAAT GGTCTCAGAAATTCCAGAGAAGAAAGCTATGGCAATTGCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAAC CCGACCATCGAATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTGCTTGGTCACCCGATGACCCGTGCCTTTAT CACCCATGCTGGTTCCCATGGTGTTTATGAAAGCATATGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAA TGCAAAGCGCATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCTGAAGATTTAGAAAATGCTCTAAAAGCAGT CATCAATGACAAAAGTTACAAGGAGAACATCATGCGCCTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTT CTGGGTGGAGTTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGACCTCACCTGGTACCAGTACCATTCCTTGGA CGTGATTGGTTTCCTCTTGGCCGTCGTGCTGACAGTGGCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAA AAAAGGGCGAGTTAAGAAAGCCCACAAATCCAAGACCCATTGAGAAGTGGGTGGGAAATAAGGTAAAATTTTGAACCATTCCCTAGTCAT TTCCAAACTTGAAAACAGAATCAGTGTTAAATTCATTTTATTCTTATTAAGGAAATACTTTGCATAAATTAATCAGCCCCAGAGTGCTTT AAAAAATTCTCTTAAATAAAAATAATAGACTCGCTAGTCAGTAAAGATATTTGAATATGTATCGTGCCCCCTCTGGTGTCTTTGATCAGG ATGACATGTGCCATTTTTCAGAGGACGTGCAGACAGGCTGGCATTCTAGATTACTTTTCTTACTCTGAAACATGGCCTGTTTGGGAGTGC GGGATTCAAAGGTGGTCCCACGGCTGCCCCTACTGCAAATGGCAGTTTTAATCTTATCTTTTGGCTTCTGCAGATGGTTGCAATTGATCC TTAACCAATAATGGTCAGTCCTCATCTCTGTCGTGCTTCATAGGTGCCACCTTGTGTGTTTAAAGAAGGGAAGCTTTGTACCTTTAGAGT GTAGGTGAAATGAATGAATGGCTTGGAGTGCACTGAGAACAGCATATGATTTCTTGCTTTGGGGAAAAAGAATGATGCTATGAAATTGGT GGGTGGTGTATTTGAGAAGATAATCATTGCTTATGTCAAATGGAGCTGAATTTGATAAAAACCCAAAATACAGCTATGAAGTGCTGGGCA >In-frame_ENST00000409813_ENST00000482026_TCGA-BR-8284-01A_DGKD_chr2_234299129_+_UGT1A3_chr2_234675680_length(amino acids)=317AA_start in transcript=79_stop in transcript=1032 MNMFLYFQTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNVNNSFTEFEAYINASGEHGIVVFS LGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGD QMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQY -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for DGKD-UGT1A3 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for DGKD-UGT1A3 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for DGKD-UGT1A3 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DGKD | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
Tgene | UGT1A3 | C0036341 | Schizophrenia | 1 | CTD_human |