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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DLG4-SHBG (FusionGDB2 ID:23075)

Fusion Gene Summary for DLG4-SHBG

check button Fusion gene summary
Fusion gene informationFusion gene name: DLG4-SHBG
Fusion gene ID: 23075
HgeneTgene
Gene symbol

DLG4

SHBG

Gene ID

3996

6462

Gene nameLLGL scribble cell polarity complex component 1sex hormone binding globulin
SynonymsDLG4|HUGL|HUGL-1|HUGL1|LLGL|Lgl1|Mgl1ABP|SBP|TEBG
Cytomap

17p11.2

17p13.1

Type of geneprotein-codingprotein-coding
Descriptionlethal(2) giant larvae protein homolog 1LLGL1, scribble cell polarity complex componenthuman homolog to the D-lgl gene proteinlethal giant larvae homolog 1, scribble cell polarity complex componentsex hormone-binding globulinsex steroid-binding proteintestis-specific androgen-binding proteintestosterone-binding beta-globulintestosterone-estradiol-binding globulintestosterone-estrogen-binding globulin
Modification date2020032920200322
UniProtAcc

P78352

.
Ensembl transtripts involved in fusion geneENST00000399506, ENST00000302955, 
ENST00000399510, ENST00000485100, 
ENST00000572262, ENST00000575314, 
ENST00000574539, ENST00000576478, 
ENST00000570547, ENST00000572182, 
ENST00000576728, ENST00000340624, 
ENST00000441599, ENST00000380450, 
ENST00000575903, ENST00000416273, 
Fusion gene scores* DoF score6 X 4 X 6=1443 X 3 X 3=27
# samples 63
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: DLG4 [Title/Abstract] AND SHBG [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDLG4(7106221)-SHBG(7536521), # samples:1
Anticipated loss of major functional domain due to fusion event.DLG4-SHBG seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDLG4

GO:0030866

cortical actin cytoskeleton organization

7542763

HgeneDLG4

GO:0065003

protein-containing complex assembly

7542763


check buttonFusion gene breakpoints across DLG4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SHBG (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-B5-A0K3DLG4chr17

7106221

-SHBGchr17

7536521

+


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Fusion Gene ORF analysis for DLG4-SHBG

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000399506ENST00000572262DLG4chr17

7106221

-SHBGchr17

7536521

+
In-frameENST00000399506ENST00000575314DLG4chr17

7106221

-SHBGchr17

7536521

+
Frame-shiftENST00000399506ENST00000574539DLG4chr17

7106221

-SHBGchr17

7536521

+
In-frameENST00000399506ENST00000576478DLG4chr17

7106221

-SHBGchr17

7536521

+
In-frameENST00000399506ENST00000570547DLG4chr17

7106221

-SHBGchr17

7536521

+
Frame-shiftENST00000399506ENST00000572182DLG4chr17

7106221

-SHBGchr17

7536521

+
Frame-shiftENST00000399506ENST00000576728DLG4chr17

7106221

-SHBGchr17

7536521

+
Frame-shiftENST00000399506ENST00000340624DLG4chr17

7106221

-SHBGchr17

7536521

+
Frame-shiftENST00000399506ENST00000441599DLG4chr17

7106221

-SHBGchr17

7536521

+
Frame-shiftENST00000399506ENST00000380450DLG4chr17

7106221

-SHBGchr17

7536521

+
In-frameENST00000399506ENST00000575903DLG4chr17

7106221

-SHBGchr17

7536521

+
Frame-shiftENST00000399506ENST00000416273DLG4chr17

7106221

-SHBGchr17

7536521

+
In-frameENST00000302955ENST00000572262DLG4chr17

7106221

-SHBGchr17

7536521

+
In-frameENST00000302955ENST00000575314DLG4chr17

7106221

-SHBGchr17

7536521

+
Frame-shiftENST00000302955ENST00000574539DLG4chr17

7106221

-SHBGchr17

7536521

+
In-frameENST00000302955ENST00000576478DLG4chr17

7106221

-SHBGchr17

7536521

+
In-frameENST00000302955ENST00000570547DLG4chr17

7106221

-SHBGchr17

7536521

+
Frame-shiftENST00000302955ENST00000572182DLG4chr17

7106221

-SHBGchr17

7536521

+
Frame-shiftENST00000302955ENST00000576728DLG4chr17

7106221

-SHBGchr17

7536521

+
Frame-shiftENST00000302955ENST00000340624DLG4chr17

7106221

-SHBGchr17

7536521

+
Frame-shiftENST00000302955ENST00000441599DLG4chr17

7106221

-SHBGchr17

7536521

+
Frame-shiftENST00000302955ENST00000380450DLG4chr17

7106221

-SHBGchr17

7536521

+
In-frameENST00000302955ENST00000575903DLG4chr17

7106221

-SHBGchr17

7536521

+
Frame-shiftENST00000302955ENST00000416273DLG4chr17

7106221

-SHBGchr17

7536521

+
In-frameENST00000399510ENST00000572262DLG4chr17

7106221

-SHBGchr17

7536521

+
In-frameENST00000399510ENST00000575314DLG4chr17

7106221

-SHBGchr17

7536521

+
Frame-shiftENST00000399510ENST00000574539DLG4chr17

7106221

-SHBGchr17

7536521

+
In-frameENST00000399510ENST00000576478DLG4chr17

7106221

-SHBGchr17

7536521

+
In-frameENST00000399510ENST00000570547DLG4chr17

7106221

-SHBGchr17

7536521

+
Frame-shiftENST00000399510ENST00000572182DLG4chr17

7106221

-SHBGchr17

7536521

+
Frame-shiftENST00000399510ENST00000576728DLG4chr17

7106221

-SHBGchr17

7536521

+
Frame-shiftENST00000399510ENST00000340624DLG4chr17

7106221

-SHBGchr17

7536521

+
Frame-shiftENST00000399510ENST00000441599DLG4chr17

7106221

-SHBGchr17

7536521

+
Frame-shiftENST00000399510ENST00000380450DLG4chr17

7106221

-SHBGchr17

7536521

+
In-frameENST00000399510ENST00000575903DLG4chr17

7106221

-SHBGchr17

7536521

+
Frame-shiftENST00000399510ENST00000416273DLG4chr17

7106221

-SHBGchr17

7536521

+
intron-3CDSENST00000485100ENST00000572262DLG4chr17

7106221

-SHBGchr17

7536521

+
intron-3CDSENST00000485100ENST00000575314DLG4chr17

7106221

-SHBGchr17

7536521

+
intron-3CDSENST00000485100ENST00000574539DLG4chr17

7106221

-SHBGchr17

7536521

+
intron-3CDSENST00000485100ENST00000576478DLG4chr17

7106221

-SHBGchr17

7536521

+
intron-3CDSENST00000485100ENST00000570547DLG4chr17

7106221

-SHBGchr17

7536521

+
intron-3CDSENST00000485100ENST00000572182DLG4chr17

7106221

-SHBGchr17

7536521

+
intron-3CDSENST00000485100ENST00000576728DLG4chr17

7106221

-SHBGchr17

7536521

+
intron-3CDSENST00000485100ENST00000340624DLG4chr17

7106221

-SHBGchr17

7536521

+
intron-3CDSENST00000485100ENST00000441599DLG4chr17

7106221

-SHBGchr17

7536521

+
intron-3CDSENST00000485100ENST00000380450DLG4chr17

7106221

-SHBGchr17

7536521

+
intron-3CDSENST00000485100ENST00000575903DLG4chr17

7106221

-SHBGchr17

7536521

+
intron-3CDSENST00000485100ENST00000416273DLG4chr17

7106221

-SHBGchr17

7536521

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000399506DLG4chr177106221-ENST00000572262SHBGchr177536521+1130979192980262
ENST00000399506DLG4chr177106221-ENST00000575314SHBGchr177536521+1130979192980262
ENST00000399506DLG4chr177106221-ENST00000576478SHBGchr177536521+1130979192980262
ENST00000399506DLG4chr177106221-ENST00000570547SHBGchr177536521+1130979192980262
ENST00000399506DLG4chr177106221-ENST00000575903SHBGchr177536521+1148979192980262
ENST00000302955DLG4chr177106221-ENST00000572262SHBGchr177536521+1129978200979259
ENST00000302955DLG4chr177106221-ENST00000575314SHBGchr177536521+1129978200979259
ENST00000302955DLG4chr177106221-ENST00000576478SHBGchr177536521+1129978200979259
ENST00000302955DLG4chr177106221-ENST00000570547SHBGchr177536521+1129978200979259
ENST00000302955DLG4chr177106221-ENST00000575903SHBGchr177536521+1147978200979259
ENST00000399510DLG4chr177106221-ENST00000572262SHBGchr177536521+192017698531770305
ENST00000399510DLG4chr177106221-ENST00000575314SHBGchr177536521+192017698531770305
ENST00000399510DLG4chr177106221-ENST00000576478SHBGchr177536521+192017698531770305
ENST00000399510DLG4chr177106221-ENST00000570547SHBGchr177536521+192017698531770305
ENST00000399510DLG4chr177106221-ENST00000575903SHBGchr177536521+193817698531770305

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000399506ENST00000572262DLG4chr177106221-SHBGchr177536521+0.0027143040.9972857
ENST00000399506ENST00000575314DLG4chr177106221-SHBGchr177536521+0.0027143040.9972857
ENST00000399506ENST00000576478DLG4chr177106221-SHBGchr177536521+0.0027143040.9972857
ENST00000399506ENST00000570547DLG4chr177106221-SHBGchr177536521+0.0027143040.9972857
ENST00000399506ENST00000575903DLG4chr177106221-SHBGchr177536521+0.0031494040.99685055
ENST00000302955ENST00000572262DLG4chr177106221-SHBGchr177536521+0.0046854660.9953145
ENST00000302955ENST00000575314DLG4chr177106221-SHBGchr177536521+0.0046854660.9953145
ENST00000302955ENST00000576478DLG4chr177106221-SHBGchr177536521+0.0046854660.9953145
ENST00000302955ENST00000570547DLG4chr177106221-SHBGchr177536521+0.0046854660.9953145
ENST00000302955ENST00000575903DLG4chr177106221-SHBGchr177536521+0.0052861010.99471384
ENST00000399510ENST00000572262DLG4chr177106221-SHBGchr177536521+0.0051632320.9948368
ENST00000399510ENST00000575314DLG4chr177106221-SHBGchr177536521+0.0051632320.9948368
ENST00000399510ENST00000576478DLG4chr177106221-SHBGchr177536521+0.0051632320.9948368
ENST00000399510ENST00000570547DLG4chr177106221-SHBGchr177536521+0.0051632320.9948368
ENST00000399510ENST00000575903DLG4chr177106221-SHBGchr177536521+0.0058131790.99418676

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Fusion Genomic Features for DLG4-SHBG


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DLG4chr177106221-SHBGchr177536521+3.38E-060.99999666
DLG4chr177106221-SHBGchr177536521+3.38E-060.99999666

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DLG4-SHBG


check button Go to

FGviewer for the breakpoints of chr17:7106221-chr17:7536521

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DLG4

P78352

.
FUNCTION: Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. {ECO:0000250|UniProtKB:Q62108}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDLG4chr17:7106221chr17:7536521ENST00000302955-820160_246259.3333333333333722.0DomainPDZ 2
HgeneDLG4chr17:7106221chr17:7536521ENST00000302955-82065_151259.3333333333333722.0DomainPDZ 1
HgeneDLG4chr17:7106221chr17:7536521ENST00000399506-820160_246262.3333333333333725.0DomainPDZ 2
HgeneDLG4chr17:7106221chr17:7536521ENST00000399506-82065_151262.3333333333333725.0DomainPDZ 1
HgeneDLG4chr17:7106221chr17:7536521ENST00000399510-1022160_246305.3333333333333768.0DomainPDZ 2
HgeneDLG4chr17:7106221chr17:7536521ENST00000399510-102265_151305.3333333333333768.0DomainPDZ 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDLG4chr17:7106221chr17:7536521ENST00000302955-820313_393259.3333333333333722.0DomainPDZ 3
HgeneDLG4chr17:7106221chr17:7536521ENST00000302955-820428_498259.3333333333333722.0DomainSH3
HgeneDLG4chr17:7106221chr17:7536521ENST00000302955-820534_709259.3333333333333722.0DomainGuanylate kinase-like
HgeneDLG4chr17:7106221chr17:7536521ENST00000399506-820313_393262.3333333333333725.0DomainPDZ 3
HgeneDLG4chr17:7106221chr17:7536521ENST00000399506-820428_498262.3333333333333725.0DomainSH3
HgeneDLG4chr17:7106221chr17:7536521ENST00000399506-820534_709262.3333333333333725.0DomainGuanylate kinase-like
HgeneDLG4chr17:7106221chr17:7536521ENST00000399510-1022313_393305.3333333333333768.0DomainPDZ 3
HgeneDLG4chr17:7106221chr17:7536521ENST00000399510-1022428_498305.3333333333333768.0DomainSH3
HgeneDLG4chr17:7106221chr17:7536521ENST00000399510-1022534_709305.3333333333333768.0DomainGuanylate kinase-like
TgeneSHBGchr17:7106221chr17:7536521ENST0000038045068224_390353.3333333333333403.0DomainLaminin G-like 2
TgeneSHBGchr17:7106221chr17:7536521ENST000003804506845_217353.3333333333333403.0DomainLaminin G-like 1
TgeneSHBGchr17:7106221chr17:7536521ENST0000041627357224_390284.0294.0DomainLaminin G-like 2
TgeneSHBGchr17:7106221chr17:7536521ENST000004162735745_217284.0294.0DomainLaminin G-like 1
TgeneSHBGchr17:7106221chr17:7536521ENST0000044159946224_390238.33333333333334288.0DomainLaminin G-like 2
TgeneSHBGchr17:7106221chr17:7536521ENST000004415994645_217238.33333333333334288.0DomainLaminin G-like 1
TgeneSHBGchr17:7106221chr17:7536521ENST0000057590368224_390335.3333333333333385.0DomainLaminin G-like 2
TgeneSHBGchr17:7106221chr17:7536521ENST000005759036845_217335.3333333333333385.0DomainLaminin G-like 1


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Fusion Gene Sequence for DLG4-SHBG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000399506_ENST00000572262_TCGA-B5-A0K3_DLG4_chr17_7106221_-_SHBG_chr17_7536521_length(transcript)=1130nt_BP=979nt
CCCCTCCCTCCCACGCTCCCCTCCCCTTCCCTTCTCCAACCCCCTCCTTCCCCTCTCACCCCTCCCCCCATCCTGGCCCCCCCTGCAAAA
GTGGGGTGCGGAGGGGGGAGGGGTGAGAACCCACGGAGGGGAGGAACGAAACTCCGATGAAGTCAGAGCCCCTTACCCGCCGCCGCGGCC
AGGCCCCCCAACATGGACTGTCTCTGTATAGTGACAACCAAGAAATACCGCTACCAAGATGAAGACACGCCCCCTCTGGAGCACAGCCCG
GCCCACCTCCCCAACCAGGCCAATTCTCCCCCAGTGATTGTCAACACAGATACCCTAGAAGCCCCAGGATATGAGTTGCAGGTGAACGGG
ACCGAGGGGGAGATGGAATACGAGGAAATCACATTGGAAAGGGGTAACTCAGGTCTGGGCTTCAGCATCGCAGGTGGCACTGACAACCCA
CACATCGGTGACGACCCATCCATTTTCATCACCAAGATCATTCCTGGTGGGGCTGCGGCCCAGGATGGCCGCCTCAGGGTCAACGACAGC
ATCCTGTTTGTAAATGAAGTGGACGTGCGCGAGGTGACCCACTCAGCGGCGGTGGAAGCCCTCAAAGAGGCAGGCTCCATCGTTCGCCTC
TATGTCATGCGCCGGAAGCCCCCGGCTGAGAAGGTCATGGAGATCAAGCTCATCAAGGGGCCTAAAGGTCTTGGCTTCAGCATCGCAGGG
GGCGTAGGGAACCAGCACATCCCAGGAGATAATAGCATCTATGTAACAAAGATCATCGAAGGGGGTGCTGCCCACAAGGATGGGAGGTTG
CAGATTGGAGACAAGATCCTGGCGGTCAACAGTGTGGGGCTAGAGGACGTCATGCATGAAGATGCTGTGGCAGCCCTGAAGAACACGTAT
GATGTTGTCTACCTAAAGGTGGCCAAGCCCAGCAATGCCTACCTGAGTGACAGCTATGCTCCCCCAGACATCACAACCTGAGAAGACTCT
TCCACCTCTTTTTGCCTGAATGGCCTTTGGGCACAAGGTCAGAGGCTGGATGTGGACCAGGCCCTGAACAGAAGCCATGAGATCTGGACT

>In-frame_ENST00000399506_ENST00000572262_TCGA-B5-A0K3_DLG4_chr17_7106221_-_SHBG_chr17_7536521_length(amino acids)=262AA_start in transcript=192_stop in transcript=980
MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGD
DPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGN

--------------------------------------------------------------
>In-frame_ENST00000399506_ENST00000575314_TCGA-B5-A0K3_DLG4_chr17_7106221_-_SHBG_chr17_7536521_length(transcript)=1130nt_BP=979nt
CCCCTCCCTCCCACGCTCCCCTCCCCTTCCCTTCTCCAACCCCCTCCTTCCCCTCTCACCCCTCCCCCCATCCTGGCCCCCCCTGCAAAA
GTGGGGTGCGGAGGGGGGAGGGGTGAGAACCCACGGAGGGGAGGAACGAAACTCCGATGAAGTCAGAGCCCCTTACCCGCCGCCGCGGCC
AGGCCCCCCAACATGGACTGTCTCTGTATAGTGACAACCAAGAAATACCGCTACCAAGATGAAGACACGCCCCCTCTGGAGCACAGCCCG
GCCCACCTCCCCAACCAGGCCAATTCTCCCCCAGTGATTGTCAACACAGATACCCTAGAAGCCCCAGGATATGAGTTGCAGGTGAACGGG
ACCGAGGGGGAGATGGAATACGAGGAAATCACATTGGAAAGGGGTAACTCAGGTCTGGGCTTCAGCATCGCAGGTGGCACTGACAACCCA
CACATCGGTGACGACCCATCCATTTTCATCACCAAGATCATTCCTGGTGGGGCTGCGGCCCAGGATGGCCGCCTCAGGGTCAACGACAGC
ATCCTGTTTGTAAATGAAGTGGACGTGCGCGAGGTGACCCACTCAGCGGCGGTGGAAGCCCTCAAAGAGGCAGGCTCCATCGTTCGCCTC
TATGTCATGCGCCGGAAGCCCCCGGCTGAGAAGGTCATGGAGATCAAGCTCATCAAGGGGCCTAAAGGTCTTGGCTTCAGCATCGCAGGG
GGCGTAGGGAACCAGCACATCCCAGGAGATAATAGCATCTATGTAACAAAGATCATCGAAGGGGGTGCTGCCCACAAGGATGGGAGGTTG
CAGATTGGAGACAAGATCCTGGCGGTCAACAGTGTGGGGCTAGAGGACGTCATGCATGAAGATGCTGTGGCAGCCCTGAAGAACACGTAT
GATGTTGTCTACCTAAAGGTGGCCAAGCCCAGCAATGCCTACCTGAGTGACAGCTATGCTCCCCCAGACATCACAACCTGAGAAGACTCT
TCCACCTCTTTTTGCCTGAATGGCCTTTGGGCACAAGGTCAGAGGCTGGATGTGGACCAGGCCCTGAACAGAAGCCATGAGATCTGGACT

>In-frame_ENST00000399506_ENST00000575314_TCGA-B5-A0K3_DLG4_chr17_7106221_-_SHBG_chr17_7536521_length(amino acids)=262AA_start in transcript=192_stop in transcript=980
MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGD
DPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGN

--------------------------------------------------------------
>In-frame_ENST00000399506_ENST00000576478_TCGA-B5-A0K3_DLG4_chr17_7106221_-_SHBG_chr17_7536521_length(transcript)=1130nt_BP=979nt
CCCCTCCCTCCCACGCTCCCCTCCCCTTCCCTTCTCCAACCCCCTCCTTCCCCTCTCACCCCTCCCCCCATCCTGGCCCCCCCTGCAAAA
GTGGGGTGCGGAGGGGGGAGGGGTGAGAACCCACGGAGGGGAGGAACGAAACTCCGATGAAGTCAGAGCCCCTTACCCGCCGCCGCGGCC
AGGCCCCCCAACATGGACTGTCTCTGTATAGTGACAACCAAGAAATACCGCTACCAAGATGAAGACACGCCCCCTCTGGAGCACAGCCCG
GCCCACCTCCCCAACCAGGCCAATTCTCCCCCAGTGATTGTCAACACAGATACCCTAGAAGCCCCAGGATATGAGTTGCAGGTGAACGGG
ACCGAGGGGGAGATGGAATACGAGGAAATCACATTGGAAAGGGGTAACTCAGGTCTGGGCTTCAGCATCGCAGGTGGCACTGACAACCCA
CACATCGGTGACGACCCATCCATTTTCATCACCAAGATCATTCCTGGTGGGGCTGCGGCCCAGGATGGCCGCCTCAGGGTCAACGACAGC
ATCCTGTTTGTAAATGAAGTGGACGTGCGCGAGGTGACCCACTCAGCGGCGGTGGAAGCCCTCAAAGAGGCAGGCTCCATCGTTCGCCTC
TATGTCATGCGCCGGAAGCCCCCGGCTGAGAAGGTCATGGAGATCAAGCTCATCAAGGGGCCTAAAGGTCTTGGCTTCAGCATCGCAGGG
GGCGTAGGGAACCAGCACATCCCAGGAGATAATAGCATCTATGTAACAAAGATCATCGAAGGGGGTGCTGCCCACAAGGATGGGAGGTTG
CAGATTGGAGACAAGATCCTGGCGGTCAACAGTGTGGGGCTAGAGGACGTCATGCATGAAGATGCTGTGGCAGCCCTGAAGAACACGTAT
GATGTTGTCTACCTAAAGGTGGCCAAGCCCAGCAATGCCTACCTGAGTGACAGCTATGCTCCCCCAGACATCACAACCTGAGAAGACTCT
TCCACCTCTTTTTGCCTGAATGGCCTTTGGGCACAAGGTCAGAGGCTGGATGTGGACCAGGCCCTGAACAGAAGCCATGAGATCTGGACT

>In-frame_ENST00000399506_ENST00000576478_TCGA-B5-A0K3_DLG4_chr17_7106221_-_SHBG_chr17_7536521_length(amino acids)=262AA_start in transcript=192_stop in transcript=980
MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGD
DPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGN

--------------------------------------------------------------
>In-frame_ENST00000399506_ENST00000570547_TCGA-B5-A0K3_DLG4_chr17_7106221_-_SHBG_chr17_7536521_length(transcript)=1130nt_BP=979nt
CCCCTCCCTCCCACGCTCCCCTCCCCTTCCCTTCTCCAACCCCCTCCTTCCCCTCTCACCCCTCCCCCCATCCTGGCCCCCCCTGCAAAA
GTGGGGTGCGGAGGGGGGAGGGGTGAGAACCCACGGAGGGGAGGAACGAAACTCCGATGAAGTCAGAGCCCCTTACCCGCCGCCGCGGCC
AGGCCCCCCAACATGGACTGTCTCTGTATAGTGACAACCAAGAAATACCGCTACCAAGATGAAGACACGCCCCCTCTGGAGCACAGCCCG
GCCCACCTCCCCAACCAGGCCAATTCTCCCCCAGTGATTGTCAACACAGATACCCTAGAAGCCCCAGGATATGAGTTGCAGGTGAACGGG
ACCGAGGGGGAGATGGAATACGAGGAAATCACATTGGAAAGGGGTAACTCAGGTCTGGGCTTCAGCATCGCAGGTGGCACTGACAACCCA
CACATCGGTGACGACCCATCCATTTTCATCACCAAGATCATTCCTGGTGGGGCTGCGGCCCAGGATGGCCGCCTCAGGGTCAACGACAGC
ATCCTGTTTGTAAATGAAGTGGACGTGCGCGAGGTGACCCACTCAGCGGCGGTGGAAGCCCTCAAAGAGGCAGGCTCCATCGTTCGCCTC
TATGTCATGCGCCGGAAGCCCCCGGCTGAGAAGGTCATGGAGATCAAGCTCATCAAGGGGCCTAAAGGTCTTGGCTTCAGCATCGCAGGG
GGCGTAGGGAACCAGCACATCCCAGGAGATAATAGCATCTATGTAACAAAGATCATCGAAGGGGGTGCTGCCCACAAGGATGGGAGGTTG
CAGATTGGAGACAAGATCCTGGCGGTCAACAGTGTGGGGCTAGAGGACGTCATGCATGAAGATGCTGTGGCAGCCCTGAAGAACACGTAT
GATGTTGTCTACCTAAAGGTGGCCAAGCCCAGCAATGCCTACCTGAGTGACAGCTATGCTCCCCCAGACATCACAACCTGAGAAGACTCT
TCCACCTCTTTTTGCCTGAATGGCCTTTGGGCACAAGGTCAGAGGCTGGATGTGGACCAGGCCCTGAACAGAAGCCATGAGATCTGGACT

>In-frame_ENST00000399506_ENST00000570547_TCGA-B5-A0K3_DLG4_chr17_7106221_-_SHBG_chr17_7536521_length(amino acids)=262AA_start in transcript=192_stop in transcript=980
MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGD
DPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGN

--------------------------------------------------------------
>In-frame_ENST00000399506_ENST00000575903_TCGA-B5-A0K3_DLG4_chr17_7106221_-_SHBG_chr17_7536521_length(transcript)=1148nt_BP=979nt
CCCCTCCCTCCCACGCTCCCCTCCCCTTCCCTTCTCCAACCCCCTCCTTCCCCTCTCACCCCTCCCCCCATCCTGGCCCCCCCTGCAAAA
GTGGGGTGCGGAGGGGGGAGGGGTGAGAACCCACGGAGGGGAGGAACGAAACTCCGATGAAGTCAGAGCCCCTTACCCGCCGCCGCGGCC
AGGCCCCCCAACATGGACTGTCTCTGTATAGTGACAACCAAGAAATACCGCTACCAAGATGAAGACACGCCCCCTCTGGAGCACAGCCCG
GCCCACCTCCCCAACCAGGCCAATTCTCCCCCAGTGATTGTCAACACAGATACCCTAGAAGCCCCAGGATATGAGTTGCAGGTGAACGGG
ACCGAGGGGGAGATGGAATACGAGGAAATCACATTGGAAAGGGGTAACTCAGGTCTGGGCTTCAGCATCGCAGGTGGCACTGACAACCCA
CACATCGGTGACGACCCATCCATTTTCATCACCAAGATCATTCCTGGTGGGGCTGCGGCCCAGGATGGCCGCCTCAGGGTCAACGACAGC
ATCCTGTTTGTAAATGAAGTGGACGTGCGCGAGGTGACCCACTCAGCGGCGGTGGAAGCCCTCAAAGAGGCAGGCTCCATCGTTCGCCTC
TATGTCATGCGCCGGAAGCCCCCGGCTGAGAAGGTCATGGAGATCAAGCTCATCAAGGGGCCTAAAGGTCTTGGCTTCAGCATCGCAGGG
GGCGTAGGGAACCAGCACATCCCAGGAGATAATAGCATCTATGTAACAAAGATCATCGAAGGGGGTGCTGCCCACAAGGATGGGAGGTTG
CAGATTGGAGACAAGATCCTGGCGGTCAACAGTGTGGGGCTAGAGGACGTCATGCATGAAGATGCTGTGGCAGCCCTGAAGAACACGTAT
GATGTTGTCTACCTAAAGGTGGCCAAGCCCAGCAATGCCTACCTGAGTGACAGCTATGCTCCCCCAGACATCACAACCTGAGAAGACTCT
TCCACCTCTTTTTGCCTGAATGGCCTTTGGGCACAAGGTCAGAGGCTGGATGTGGACCAGGCCCTGAACAGAAGCCATGAGATCTGGACT

>In-frame_ENST00000399506_ENST00000575903_TCGA-B5-A0K3_DLG4_chr17_7106221_-_SHBG_chr17_7536521_length(amino acids)=262AA_start in transcript=192_stop in transcript=980
MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGD
DPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGN

--------------------------------------------------------------
>In-frame_ENST00000302955_ENST00000572262_TCGA-B5-A0K3_DLG4_chr17_7106221_-_SHBG_chr17_7536521_length(transcript)=1129nt_BP=978nt
GCCCCCTTCCCCTCCCTCCCACGCTCCCCTCCCCTTCCCTTCTCCAACCCCCTCCTTCCCCTCTCACCCCTCCCCCCATCCTGGCCCCCC
CTGCAAAAGTGGGGTGCGGAGGGGGGAGGGGTGAGAACCCACGGAGGGGAGGAACGAAACTCCGATGAAGTCAGAGCCCCTTACCCGCCG
CCGCGGCCAGGCCCCCCAACATGGACTGTCTCTGTATAGTGACAACCAAGAAATACCGCTACCAAGATGAAGACACGCCCCCTCTGGAGC
ACAGCCCGGCCCACCTCCCCAACCAGGCCAATTCTCCCCCAGTGATTGTCAACACAGATACCCTAGAAGCCCCAGGATATGTGAACGGGA
CCGAGGGGGAGATGGAATACGAGGAAATCACATTGGAAAGGGGTAACTCAGGTCTGGGCTTCAGCATCGCAGGTGGCACTGACAACCCAC
ACATCGGTGACGACCCATCCATTTTCATCACCAAGATCATTCCTGGTGGGGCTGCGGCCCAGGATGGCCGCCTCAGGGTCAACGACAGCA
TCCTGTTTGTAAATGAAGTGGACGTGCGCGAGGTGACCCACTCAGCGGCGGTGGAAGCCCTCAAAGAGGCAGGCTCCATCGTTCGCCTCT
ATGTCATGCGCCGGAAGCCCCCGGCTGAGAAGGTCATGGAGATCAAGCTCATCAAGGGGCCTAAAGGTCTTGGCTTCAGCATCGCAGGGG
GCGTAGGGAACCAGCACATCCCAGGAGATAATAGCATCTATGTAACAAAGATCATCGAAGGGGGTGCTGCCCACAAGGATGGGAGGTTGC
AGATTGGAGACAAGATCCTGGCGGTCAACAGTGTGGGGCTAGAGGACGTCATGCATGAAGATGCTGTGGCAGCCCTGAAGAACACGTATG
ATGTTGTCTACCTAAAGGTGGCCAAGCCCAGCAATGCCTACCTGAGTGACAGCTATGCTCCCCCAGACATCACAACCTGAGAAGACTCTT
CCACCTCTTTTTGCCTGAATGGCCTTTGGGCACAAGGTCAGAGGCTGGATGTGGACCAGGCCCTGAACAGAAGCCATGAGATCTGGACTC

>In-frame_ENST00000302955_ENST00000572262_TCGA-B5-A0K3_DLG4_chr17_7106221_-_SHBG_chr17_7536521_length(amino acids)=259AA_start in transcript=200_stop in transcript=979
MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPS
IFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHI

--------------------------------------------------------------
>In-frame_ENST00000302955_ENST00000575314_TCGA-B5-A0K3_DLG4_chr17_7106221_-_SHBG_chr17_7536521_length(transcript)=1129nt_BP=978nt
GCCCCCTTCCCCTCCCTCCCACGCTCCCCTCCCCTTCCCTTCTCCAACCCCCTCCTTCCCCTCTCACCCCTCCCCCCATCCTGGCCCCCC
CTGCAAAAGTGGGGTGCGGAGGGGGGAGGGGTGAGAACCCACGGAGGGGAGGAACGAAACTCCGATGAAGTCAGAGCCCCTTACCCGCCG
CCGCGGCCAGGCCCCCCAACATGGACTGTCTCTGTATAGTGACAACCAAGAAATACCGCTACCAAGATGAAGACACGCCCCCTCTGGAGC
ACAGCCCGGCCCACCTCCCCAACCAGGCCAATTCTCCCCCAGTGATTGTCAACACAGATACCCTAGAAGCCCCAGGATATGTGAACGGGA
CCGAGGGGGAGATGGAATACGAGGAAATCACATTGGAAAGGGGTAACTCAGGTCTGGGCTTCAGCATCGCAGGTGGCACTGACAACCCAC
ACATCGGTGACGACCCATCCATTTTCATCACCAAGATCATTCCTGGTGGGGCTGCGGCCCAGGATGGCCGCCTCAGGGTCAACGACAGCA
TCCTGTTTGTAAATGAAGTGGACGTGCGCGAGGTGACCCACTCAGCGGCGGTGGAAGCCCTCAAAGAGGCAGGCTCCATCGTTCGCCTCT
ATGTCATGCGCCGGAAGCCCCCGGCTGAGAAGGTCATGGAGATCAAGCTCATCAAGGGGCCTAAAGGTCTTGGCTTCAGCATCGCAGGGG
GCGTAGGGAACCAGCACATCCCAGGAGATAATAGCATCTATGTAACAAAGATCATCGAAGGGGGTGCTGCCCACAAGGATGGGAGGTTGC
AGATTGGAGACAAGATCCTGGCGGTCAACAGTGTGGGGCTAGAGGACGTCATGCATGAAGATGCTGTGGCAGCCCTGAAGAACACGTATG
ATGTTGTCTACCTAAAGGTGGCCAAGCCCAGCAATGCCTACCTGAGTGACAGCTATGCTCCCCCAGACATCACAACCTGAGAAGACTCTT
CCACCTCTTTTTGCCTGAATGGCCTTTGGGCACAAGGTCAGAGGCTGGATGTGGACCAGGCCCTGAACAGAAGCCATGAGATCTGGACTC

>In-frame_ENST00000302955_ENST00000575314_TCGA-B5-A0K3_DLG4_chr17_7106221_-_SHBG_chr17_7536521_length(amino acids)=259AA_start in transcript=200_stop in transcript=979
MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPS
IFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHI

--------------------------------------------------------------
>In-frame_ENST00000302955_ENST00000576478_TCGA-B5-A0K3_DLG4_chr17_7106221_-_SHBG_chr17_7536521_length(transcript)=1129nt_BP=978nt
GCCCCCTTCCCCTCCCTCCCACGCTCCCCTCCCCTTCCCTTCTCCAACCCCCTCCTTCCCCTCTCACCCCTCCCCCCATCCTGGCCCCCC
CTGCAAAAGTGGGGTGCGGAGGGGGGAGGGGTGAGAACCCACGGAGGGGAGGAACGAAACTCCGATGAAGTCAGAGCCCCTTACCCGCCG
CCGCGGCCAGGCCCCCCAACATGGACTGTCTCTGTATAGTGACAACCAAGAAATACCGCTACCAAGATGAAGACACGCCCCCTCTGGAGC
ACAGCCCGGCCCACCTCCCCAACCAGGCCAATTCTCCCCCAGTGATTGTCAACACAGATACCCTAGAAGCCCCAGGATATGTGAACGGGA
CCGAGGGGGAGATGGAATACGAGGAAATCACATTGGAAAGGGGTAACTCAGGTCTGGGCTTCAGCATCGCAGGTGGCACTGACAACCCAC
ACATCGGTGACGACCCATCCATTTTCATCACCAAGATCATTCCTGGTGGGGCTGCGGCCCAGGATGGCCGCCTCAGGGTCAACGACAGCA
TCCTGTTTGTAAATGAAGTGGACGTGCGCGAGGTGACCCACTCAGCGGCGGTGGAAGCCCTCAAAGAGGCAGGCTCCATCGTTCGCCTCT
ATGTCATGCGCCGGAAGCCCCCGGCTGAGAAGGTCATGGAGATCAAGCTCATCAAGGGGCCTAAAGGTCTTGGCTTCAGCATCGCAGGGG
GCGTAGGGAACCAGCACATCCCAGGAGATAATAGCATCTATGTAACAAAGATCATCGAAGGGGGTGCTGCCCACAAGGATGGGAGGTTGC
AGATTGGAGACAAGATCCTGGCGGTCAACAGTGTGGGGCTAGAGGACGTCATGCATGAAGATGCTGTGGCAGCCCTGAAGAACACGTATG
ATGTTGTCTACCTAAAGGTGGCCAAGCCCAGCAATGCCTACCTGAGTGACAGCTATGCTCCCCCAGACATCACAACCTGAGAAGACTCTT
CCACCTCTTTTTGCCTGAATGGCCTTTGGGCACAAGGTCAGAGGCTGGATGTGGACCAGGCCCTGAACAGAAGCCATGAGATCTGGACTC

>In-frame_ENST00000302955_ENST00000576478_TCGA-B5-A0K3_DLG4_chr17_7106221_-_SHBG_chr17_7536521_length(amino acids)=259AA_start in transcript=200_stop in transcript=979
MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPS
IFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHI

--------------------------------------------------------------
>In-frame_ENST00000302955_ENST00000570547_TCGA-B5-A0K3_DLG4_chr17_7106221_-_SHBG_chr17_7536521_length(transcript)=1129nt_BP=978nt
GCCCCCTTCCCCTCCCTCCCACGCTCCCCTCCCCTTCCCTTCTCCAACCCCCTCCTTCCCCTCTCACCCCTCCCCCCATCCTGGCCCCCC
CTGCAAAAGTGGGGTGCGGAGGGGGGAGGGGTGAGAACCCACGGAGGGGAGGAACGAAACTCCGATGAAGTCAGAGCCCCTTACCCGCCG
CCGCGGCCAGGCCCCCCAACATGGACTGTCTCTGTATAGTGACAACCAAGAAATACCGCTACCAAGATGAAGACACGCCCCCTCTGGAGC
ACAGCCCGGCCCACCTCCCCAACCAGGCCAATTCTCCCCCAGTGATTGTCAACACAGATACCCTAGAAGCCCCAGGATATGTGAACGGGA
CCGAGGGGGAGATGGAATACGAGGAAATCACATTGGAAAGGGGTAACTCAGGTCTGGGCTTCAGCATCGCAGGTGGCACTGACAACCCAC
ACATCGGTGACGACCCATCCATTTTCATCACCAAGATCATTCCTGGTGGGGCTGCGGCCCAGGATGGCCGCCTCAGGGTCAACGACAGCA
TCCTGTTTGTAAATGAAGTGGACGTGCGCGAGGTGACCCACTCAGCGGCGGTGGAAGCCCTCAAAGAGGCAGGCTCCATCGTTCGCCTCT
ATGTCATGCGCCGGAAGCCCCCGGCTGAGAAGGTCATGGAGATCAAGCTCATCAAGGGGCCTAAAGGTCTTGGCTTCAGCATCGCAGGGG
GCGTAGGGAACCAGCACATCCCAGGAGATAATAGCATCTATGTAACAAAGATCATCGAAGGGGGTGCTGCCCACAAGGATGGGAGGTTGC
AGATTGGAGACAAGATCCTGGCGGTCAACAGTGTGGGGCTAGAGGACGTCATGCATGAAGATGCTGTGGCAGCCCTGAAGAACACGTATG
ATGTTGTCTACCTAAAGGTGGCCAAGCCCAGCAATGCCTACCTGAGTGACAGCTATGCTCCCCCAGACATCACAACCTGAGAAGACTCTT
CCACCTCTTTTTGCCTGAATGGCCTTTGGGCACAAGGTCAGAGGCTGGATGTGGACCAGGCCCTGAACAGAAGCCATGAGATCTGGACTC

>In-frame_ENST00000302955_ENST00000570547_TCGA-B5-A0K3_DLG4_chr17_7106221_-_SHBG_chr17_7536521_length(amino acids)=259AA_start in transcript=200_stop in transcript=979
MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPS
IFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHI

--------------------------------------------------------------
>In-frame_ENST00000302955_ENST00000575903_TCGA-B5-A0K3_DLG4_chr17_7106221_-_SHBG_chr17_7536521_length(transcript)=1147nt_BP=978nt
GCCCCCTTCCCCTCCCTCCCACGCTCCCCTCCCCTTCCCTTCTCCAACCCCCTCCTTCCCCTCTCACCCCTCCCCCCATCCTGGCCCCCC
CTGCAAAAGTGGGGTGCGGAGGGGGGAGGGGTGAGAACCCACGGAGGGGAGGAACGAAACTCCGATGAAGTCAGAGCCCCTTACCCGCCG
CCGCGGCCAGGCCCCCCAACATGGACTGTCTCTGTATAGTGACAACCAAGAAATACCGCTACCAAGATGAAGACACGCCCCCTCTGGAGC
ACAGCCCGGCCCACCTCCCCAACCAGGCCAATTCTCCCCCAGTGATTGTCAACACAGATACCCTAGAAGCCCCAGGATATGTGAACGGGA
CCGAGGGGGAGATGGAATACGAGGAAATCACATTGGAAAGGGGTAACTCAGGTCTGGGCTTCAGCATCGCAGGTGGCACTGACAACCCAC
ACATCGGTGACGACCCATCCATTTTCATCACCAAGATCATTCCTGGTGGGGCTGCGGCCCAGGATGGCCGCCTCAGGGTCAACGACAGCA
TCCTGTTTGTAAATGAAGTGGACGTGCGCGAGGTGACCCACTCAGCGGCGGTGGAAGCCCTCAAAGAGGCAGGCTCCATCGTTCGCCTCT
ATGTCATGCGCCGGAAGCCCCCGGCTGAGAAGGTCATGGAGATCAAGCTCATCAAGGGGCCTAAAGGTCTTGGCTTCAGCATCGCAGGGG
GCGTAGGGAACCAGCACATCCCAGGAGATAATAGCATCTATGTAACAAAGATCATCGAAGGGGGTGCTGCCCACAAGGATGGGAGGTTGC
AGATTGGAGACAAGATCCTGGCGGTCAACAGTGTGGGGCTAGAGGACGTCATGCATGAAGATGCTGTGGCAGCCCTGAAGAACACGTATG
ATGTTGTCTACCTAAAGGTGGCCAAGCCCAGCAATGCCTACCTGAGTGACAGCTATGCTCCCCCAGACATCACAACCTGAGAAGACTCTT
CCACCTCTTTTTGCCTGAATGGCCTTTGGGCACAAGGTCAGAGGCTGGATGTGGACCAGGCCCTGAACAGAAGCCATGAGATCTGGACTC

>In-frame_ENST00000302955_ENST00000575903_TCGA-B5-A0K3_DLG4_chr17_7106221_-_SHBG_chr17_7536521_length(amino acids)=259AA_start in transcript=200_stop in transcript=979
MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPS
IFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHI

--------------------------------------------------------------
>In-frame_ENST00000399510_ENST00000572262_TCGA-B5-A0K3_DLG4_chr17_7106221_-_SHBG_chr17_7536521_length(transcript)=1920nt_BP=1769nt
GGGACAGAAGAGGAAGGGGCTTAAGTCACTGCAGCCAGAGGGATGGAGGTGGACTGAAGGGAGGGCTTCTCCGGTGGGGTTAGAAGGGAA
AAGTAGGGAAAGAGAAGTGTAAGGTAGATGGCAGAGGCAGAGACATGGAAAGACAGACTCTAGGGTTCCTGATGAAATCTATCTCGGCCA
ACACAAAAGGGAGGGTACAGTGGTGGGGGGCACCCAAGCTAGGGTGTGAGTACCCTAAGTGTATTCTTCTGAGATGTAGGCCATTCACTA
ACTCTTGGAACAGCTACAGTTTCACAGTAGGAAGACCCCCCCAGATTCACTGCCCCTCCCTTAGTAAAGCCTCTGAGACCTTCCTGAACA
TTCCCTTCTGTCTTTGCCCTCTGTTCCTTCCAGAGACCATGTGCCCAGGCAGATGGATTCCTCCCGGGCCTGAGAGGAACTGCAGGAATT
CTCCTGCCTCTTACCCGTAAAACCCCAACTTCTCTAGCCCTAGGGCAGGAAGTCCCAAACAATTTCTACCCCTTTTTCTGCAATTCTCAT
TGGGGTGAGAGGAGGCCCAGGAGGAGAGAGAGCTGGGCTCAGCTTCTTTTTGAGCTGCTGGAGCCCTCTGTGAGGAGGCCCTCTTTGCTG
GCTTCTCAGGAGAGCGTGGCTAGGTTCTGCCTGCCTATGGGAAGAGGGGGCCAGGGTGTGTGGAGCAAGATGGTGGCGGTGCTGGTGCCT
TGGGACCTGGGGGAATGGGACAGCTGGTCGGCTCAGAGACGGCCTACTTTACTCACAGCTGGAATTTAGTGGGGAGAAGCAGCTCAACTC
CAATCCTGGAGGATTAGGGAGATTAAAGTGAGAGAAGAGAGAGATGTCCCAGAGACCAAGAGCTCCCAGGTCAGCCCTCTGGCTCCTGGC
ACCCCCACTGCTGCGGTGGGCACCCCCACTCCTCACAGTGCTGCATAGCGACCTCTTCCAGGCCTTGCTGGACATCCTGGACTATTATGA
GGCTTCCCTCTCAGAGAGTCAGAAATACCGCTACCAAGATGAAGACACGCCCCCTCTGGAGCACAGCCCGGCCCACCTCCCCAACCAGGC
CAATTCTCCCCCAGTGATTGTCAACACAGATACCCTAGAAGCCCCAGGATATGAGTTGCAGGTGAACGGGACCGAGGGGGAGATGGAATA
CGAGGAAATCACATTGGAAAGGGGTAACTCAGGTCTGGGCTTCAGCATCGCAGGTGGCACTGACAACCCACACATCGGTGACGACCCATC
CATTTTCATCACCAAGATCATTCCTGGTGGGGCTGCGGCCCAGGATGGCCGCCTCAGGGTCAACGACAGCATCCTGTTTGTAAATGAAGT
GGACGTGCGCGAGGTGACCCACTCAGCGGCGGTGGAAGCCCTCAAAGAGGCAGGCTCCATCGTTCGCCTCTATGTCATGCGCCGGAAGCC
CCCGGCTGAGAAGGTCATGGAGATCAAGCTCATCAAGGGGCCTAAAGGTCTTGGCTTCAGCATCGCAGGGGGCGTAGGGAACCAGCACAT
CCCAGGAGATAATAGCATCTATGTAACAAAGATCATCGAAGGGGGTGCTGCCCACAAGGATGGGAGGTTGCAGATTGGAGACAAGATCCT
GGCGGTCAACAGTGTGGGGCTAGAGGACGTCATGCATGAAGATGCTGTGGCAGCCCTGAAGAACACGTATGATGTTGTCTACCTAAAGGT
GGCCAAGCCCAGCAATGCCTACCTGAGTGACAGCTATGCTCCCCCAGACATCACAACCTGAGAAGACTCTTCCACCTCTTTTTGCCTGAA
TGGCCTTTGGGCACAAGGTCAGAGGCTGGATGTGGACCAGGCCCTGAACAGAAGCCATGAGATCTGGACTCACAGCTGCCCCCAGAGCCC

>In-frame_ENST00000399510_ENST00000572262_TCGA-B5-A0K3_DLG4_chr17_7106221_-_SHBG_chr17_7536521_length(amino acids)=305AA_start in transcript=853_stop in transcript=1770
MSQRPRAPRSALWLLAPPLLRWAPPLLTVLHSDLFQALLDILDYYEASLSESQKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEA
PGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEAL
KEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHED

--------------------------------------------------------------
>In-frame_ENST00000399510_ENST00000575314_TCGA-B5-A0K3_DLG4_chr17_7106221_-_SHBG_chr17_7536521_length(transcript)=1920nt_BP=1769nt
GGGACAGAAGAGGAAGGGGCTTAAGTCACTGCAGCCAGAGGGATGGAGGTGGACTGAAGGGAGGGCTTCTCCGGTGGGGTTAGAAGGGAA
AAGTAGGGAAAGAGAAGTGTAAGGTAGATGGCAGAGGCAGAGACATGGAAAGACAGACTCTAGGGTTCCTGATGAAATCTATCTCGGCCA
ACACAAAAGGGAGGGTACAGTGGTGGGGGGCACCCAAGCTAGGGTGTGAGTACCCTAAGTGTATTCTTCTGAGATGTAGGCCATTCACTA
ACTCTTGGAACAGCTACAGTTTCACAGTAGGAAGACCCCCCCAGATTCACTGCCCCTCCCTTAGTAAAGCCTCTGAGACCTTCCTGAACA
TTCCCTTCTGTCTTTGCCCTCTGTTCCTTCCAGAGACCATGTGCCCAGGCAGATGGATTCCTCCCGGGCCTGAGAGGAACTGCAGGAATT
CTCCTGCCTCTTACCCGTAAAACCCCAACTTCTCTAGCCCTAGGGCAGGAAGTCCCAAACAATTTCTACCCCTTTTTCTGCAATTCTCAT
TGGGGTGAGAGGAGGCCCAGGAGGAGAGAGAGCTGGGCTCAGCTTCTTTTTGAGCTGCTGGAGCCCTCTGTGAGGAGGCCCTCTTTGCTG
GCTTCTCAGGAGAGCGTGGCTAGGTTCTGCCTGCCTATGGGAAGAGGGGGCCAGGGTGTGTGGAGCAAGATGGTGGCGGTGCTGGTGCCT
TGGGACCTGGGGGAATGGGACAGCTGGTCGGCTCAGAGACGGCCTACTTTACTCACAGCTGGAATTTAGTGGGGAGAAGCAGCTCAACTC
CAATCCTGGAGGATTAGGGAGATTAAAGTGAGAGAAGAGAGAGATGTCCCAGAGACCAAGAGCTCCCAGGTCAGCCCTCTGGCTCCTGGC
ACCCCCACTGCTGCGGTGGGCACCCCCACTCCTCACAGTGCTGCATAGCGACCTCTTCCAGGCCTTGCTGGACATCCTGGACTATTATGA
GGCTTCCCTCTCAGAGAGTCAGAAATACCGCTACCAAGATGAAGACACGCCCCCTCTGGAGCACAGCCCGGCCCACCTCCCCAACCAGGC
CAATTCTCCCCCAGTGATTGTCAACACAGATACCCTAGAAGCCCCAGGATATGAGTTGCAGGTGAACGGGACCGAGGGGGAGATGGAATA
CGAGGAAATCACATTGGAAAGGGGTAACTCAGGTCTGGGCTTCAGCATCGCAGGTGGCACTGACAACCCACACATCGGTGACGACCCATC
CATTTTCATCACCAAGATCATTCCTGGTGGGGCTGCGGCCCAGGATGGCCGCCTCAGGGTCAACGACAGCATCCTGTTTGTAAATGAAGT
GGACGTGCGCGAGGTGACCCACTCAGCGGCGGTGGAAGCCCTCAAAGAGGCAGGCTCCATCGTTCGCCTCTATGTCATGCGCCGGAAGCC
CCCGGCTGAGAAGGTCATGGAGATCAAGCTCATCAAGGGGCCTAAAGGTCTTGGCTTCAGCATCGCAGGGGGCGTAGGGAACCAGCACAT
CCCAGGAGATAATAGCATCTATGTAACAAAGATCATCGAAGGGGGTGCTGCCCACAAGGATGGGAGGTTGCAGATTGGAGACAAGATCCT
GGCGGTCAACAGTGTGGGGCTAGAGGACGTCATGCATGAAGATGCTGTGGCAGCCCTGAAGAACACGTATGATGTTGTCTACCTAAAGGT
GGCCAAGCCCAGCAATGCCTACCTGAGTGACAGCTATGCTCCCCCAGACATCACAACCTGAGAAGACTCTTCCACCTCTTTTTGCCTGAA
TGGCCTTTGGGCACAAGGTCAGAGGCTGGATGTGGACCAGGCCCTGAACAGAAGCCATGAGATCTGGACTCACAGCTGCCCCCAGAGCCC

>In-frame_ENST00000399510_ENST00000575314_TCGA-B5-A0K3_DLG4_chr17_7106221_-_SHBG_chr17_7536521_length(amino acids)=305AA_start in transcript=853_stop in transcript=1770
MSQRPRAPRSALWLLAPPLLRWAPPLLTVLHSDLFQALLDILDYYEASLSESQKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEA
PGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEAL
KEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHED

--------------------------------------------------------------
>In-frame_ENST00000399510_ENST00000576478_TCGA-B5-A0K3_DLG4_chr17_7106221_-_SHBG_chr17_7536521_length(transcript)=1920nt_BP=1769nt
GGGACAGAAGAGGAAGGGGCTTAAGTCACTGCAGCCAGAGGGATGGAGGTGGACTGAAGGGAGGGCTTCTCCGGTGGGGTTAGAAGGGAA
AAGTAGGGAAAGAGAAGTGTAAGGTAGATGGCAGAGGCAGAGACATGGAAAGACAGACTCTAGGGTTCCTGATGAAATCTATCTCGGCCA
ACACAAAAGGGAGGGTACAGTGGTGGGGGGCACCCAAGCTAGGGTGTGAGTACCCTAAGTGTATTCTTCTGAGATGTAGGCCATTCACTA
ACTCTTGGAACAGCTACAGTTTCACAGTAGGAAGACCCCCCCAGATTCACTGCCCCTCCCTTAGTAAAGCCTCTGAGACCTTCCTGAACA
TTCCCTTCTGTCTTTGCCCTCTGTTCCTTCCAGAGACCATGTGCCCAGGCAGATGGATTCCTCCCGGGCCTGAGAGGAACTGCAGGAATT
CTCCTGCCTCTTACCCGTAAAACCCCAACTTCTCTAGCCCTAGGGCAGGAAGTCCCAAACAATTTCTACCCCTTTTTCTGCAATTCTCAT
TGGGGTGAGAGGAGGCCCAGGAGGAGAGAGAGCTGGGCTCAGCTTCTTTTTGAGCTGCTGGAGCCCTCTGTGAGGAGGCCCTCTTTGCTG
GCTTCTCAGGAGAGCGTGGCTAGGTTCTGCCTGCCTATGGGAAGAGGGGGCCAGGGTGTGTGGAGCAAGATGGTGGCGGTGCTGGTGCCT
TGGGACCTGGGGGAATGGGACAGCTGGTCGGCTCAGAGACGGCCTACTTTACTCACAGCTGGAATTTAGTGGGGAGAAGCAGCTCAACTC
CAATCCTGGAGGATTAGGGAGATTAAAGTGAGAGAAGAGAGAGATGTCCCAGAGACCAAGAGCTCCCAGGTCAGCCCTCTGGCTCCTGGC
ACCCCCACTGCTGCGGTGGGCACCCCCACTCCTCACAGTGCTGCATAGCGACCTCTTCCAGGCCTTGCTGGACATCCTGGACTATTATGA
GGCTTCCCTCTCAGAGAGTCAGAAATACCGCTACCAAGATGAAGACACGCCCCCTCTGGAGCACAGCCCGGCCCACCTCCCCAACCAGGC
CAATTCTCCCCCAGTGATTGTCAACACAGATACCCTAGAAGCCCCAGGATATGAGTTGCAGGTGAACGGGACCGAGGGGGAGATGGAATA
CGAGGAAATCACATTGGAAAGGGGTAACTCAGGTCTGGGCTTCAGCATCGCAGGTGGCACTGACAACCCACACATCGGTGACGACCCATC
CATTTTCATCACCAAGATCATTCCTGGTGGGGCTGCGGCCCAGGATGGCCGCCTCAGGGTCAACGACAGCATCCTGTTTGTAAATGAAGT
GGACGTGCGCGAGGTGACCCACTCAGCGGCGGTGGAAGCCCTCAAAGAGGCAGGCTCCATCGTTCGCCTCTATGTCATGCGCCGGAAGCC
CCCGGCTGAGAAGGTCATGGAGATCAAGCTCATCAAGGGGCCTAAAGGTCTTGGCTTCAGCATCGCAGGGGGCGTAGGGAACCAGCACAT
CCCAGGAGATAATAGCATCTATGTAACAAAGATCATCGAAGGGGGTGCTGCCCACAAGGATGGGAGGTTGCAGATTGGAGACAAGATCCT
GGCGGTCAACAGTGTGGGGCTAGAGGACGTCATGCATGAAGATGCTGTGGCAGCCCTGAAGAACACGTATGATGTTGTCTACCTAAAGGT
GGCCAAGCCCAGCAATGCCTACCTGAGTGACAGCTATGCTCCCCCAGACATCACAACCTGAGAAGACTCTTCCACCTCTTTTTGCCTGAA
TGGCCTTTGGGCACAAGGTCAGAGGCTGGATGTGGACCAGGCCCTGAACAGAAGCCATGAGATCTGGACTCACAGCTGCCCCCAGAGCCC

>In-frame_ENST00000399510_ENST00000576478_TCGA-B5-A0K3_DLG4_chr17_7106221_-_SHBG_chr17_7536521_length(amino acids)=305AA_start in transcript=853_stop in transcript=1770
MSQRPRAPRSALWLLAPPLLRWAPPLLTVLHSDLFQALLDILDYYEASLSESQKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEA
PGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEAL
KEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHED

--------------------------------------------------------------
>In-frame_ENST00000399510_ENST00000570547_TCGA-B5-A0K3_DLG4_chr17_7106221_-_SHBG_chr17_7536521_length(transcript)=1920nt_BP=1769nt
GGGACAGAAGAGGAAGGGGCTTAAGTCACTGCAGCCAGAGGGATGGAGGTGGACTGAAGGGAGGGCTTCTCCGGTGGGGTTAGAAGGGAA
AAGTAGGGAAAGAGAAGTGTAAGGTAGATGGCAGAGGCAGAGACATGGAAAGACAGACTCTAGGGTTCCTGATGAAATCTATCTCGGCCA
ACACAAAAGGGAGGGTACAGTGGTGGGGGGCACCCAAGCTAGGGTGTGAGTACCCTAAGTGTATTCTTCTGAGATGTAGGCCATTCACTA
ACTCTTGGAACAGCTACAGTTTCACAGTAGGAAGACCCCCCCAGATTCACTGCCCCTCCCTTAGTAAAGCCTCTGAGACCTTCCTGAACA
TTCCCTTCTGTCTTTGCCCTCTGTTCCTTCCAGAGACCATGTGCCCAGGCAGATGGATTCCTCCCGGGCCTGAGAGGAACTGCAGGAATT
CTCCTGCCTCTTACCCGTAAAACCCCAACTTCTCTAGCCCTAGGGCAGGAAGTCCCAAACAATTTCTACCCCTTTTTCTGCAATTCTCAT
TGGGGTGAGAGGAGGCCCAGGAGGAGAGAGAGCTGGGCTCAGCTTCTTTTTGAGCTGCTGGAGCCCTCTGTGAGGAGGCCCTCTTTGCTG
GCTTCTCAGGAGAGCGTGGCTAGGTTCTGCCTGCCTATGGGAAGAGGGGGCCAGGGTGTGTGGAGCAAGATGGTGGCGGTGCTGGTGCCT
TGGGACCTGGGGGAATGGGACAGCTGGTCGGCTCAGAGACGGCCTACTTTACTCACAGCTGGAATTTAGTGGGGAGAAGCAGCTCAACTC
CAATCCTGGAGGATTAGGGAGATTAAAGTGAGAGAAGAGAGAGATGTCCCAGAGACCAAGAGCTCCCAGGTCAGCCCTCTGGCTCCTGGC
ACCCCCACTGCTGCGGTGGGCACCCCCACTCCTCACAGTGCTGCATAGCGACCTCTTCCAGGCCTTGCTGGACATCCTGGACTATTATGA
GGCTTCCCTCTCAGAGAGTCAGAAATACCGCTACCAAGATGAAGACACGCCCCCTCTGGAGCACAGCCCGGCCCACCTCCCCAACCAGGC
CAATTCTCCCCCAGTGATTGTCAACACAGATACCCTAGAAGCCCCAGGATATGAGTTGCAGGTGAACGGGACCGAGGGGGAGATGGAATA
CGAGGAAATCACATTGGAAAGGGGTAACTCAGGTCTGGGCTTCAGCATCGCAGGTGGCACTGACAACCCACACATCGGTGACGACCCATC
CATTTTCATCACCAAGATCATTCCTGGTGGGGCTGCGGCCCAGGATGGCCGCCTCAGGGTCAACGACAGCATCCTGTTTGTAAATGAAGT
GGACGTGCGCGAGGTGACCCACTCAGCGGCGGTGGAAGCCCTCAAAGAGGCAGGCTCCATCGTTCGCCTCTATGTCATGCGCCGGAAGCC
CCCGGCTGAGAAGGTCATGGAGATCAAGCTCATCAAGGGGCCTAAAGGTCTTGGCTTCAGCATCGCAGGGGGCGTAGGGAACCAGCACAT
CCCAGGAGATAATAGCATCTATGTAACAAAGATCATCGAAGGGGGTGCTGCCCACAAGGATGGGAGGTTGCAGATTGGAGACAAGATCCT
GGCGGTCAACAGTGTGGGGCTAGAGGACGTCATGCATGAAGATGCTGTGGCAGCCCTGAAGAACACGTATGATGTTGTCTACCTAAAGGT
GGCCAAGCCCAGCAATGCCTACCTGAGTGACAGCTATGCTCCCCCAGACATCACAACCTGAGAAGACTCTTCCACCTCTTTTTGCCTGAA
TGGCCTTTGGGCACAAGGTCAGAGGCTGGATGTGGACCAGGCCCTGAACAGAAGCCATGAGATCTGGACTCACAGCTGCCCCCAGAGCCC

>In-frame_ENST00000399510_ENST00000570547_TCGA-B5-A0K3_DLG4_chr17_7106221_-_SHBG_chr17_7536521_length(amino acids)=305AA_start in transcript=853_stop in transcript=1770
MSQRPRAPRSALWLLAPPLLRWAPPLLTVLHSDLFQALLDILDYYEASLSESQKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEA
PGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEAL
KEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHED

--------------------------------------------------------------
>In-frame_ENST00000399510_ENST00000575903_TCGA-B5-A0K3_DLG4_chr17_7106221_-_SHBG_chr17_7536521_length(transcript)=1938nt_BP=1769nt
GGGACAGAAGAGGAAGGGGCTTAAGTCACTGCAGCCAGAGGGATGGAGGTGGACTGAAGGGAGGGCTTCTCCGGTGGGGTTAGAAGGGAA
AAGTAGGGAAAGAGAAGTGTAAGGTAGATGGCAGAGGCAGAGACATGGAAAGACAGACTCTAGGGTTCCTGATGAAATCTATCTCGGCCA
ACACAAAAGGGAGGGTACAGTGGTGGGGGGCACCCAAGCTAGGGTGTGAGTACCCTAAGTGTATTCTTCTGAGATGTAGGCCATTCACTA
ACTCTTGGAACAGCTACAGTTTCACAGTAGGAAGACCCCCCCAGATTCACTGCCCCTCCCTTAGTAAAGCCTCTGAGACCTTCCTGAACA
TTCCCTTCTGTCTTTGCCCTCTGTTCCTTCCAGAGACCATGTGCCCAGGCAGATGGATTCCTCCCGGGCCTGAGAGGAACTGCAGGAATT
CTCCTGCCTCTTACCCGTAAAACCCCAACTTCTCTAGCCCTAGGGCAGGAAGTCCCAAACAATTTCTACCCCTTTTTCTGCAATTCTCAT
TGGGGTGAGAGGAGGCCCAGGAGGAGAGAGAGCTGGGCTCAGCTTCTTTTTGAGCTGCTGGAGCCCTCTGTGAGGAGGCCCTCTTTGCTG
GCTTCTCAGGAGAGCGTGGCTAGGTTCTGCCTGCCTATGGGAAGAGGGGGCCAGGGTGTGTGGAGCAAGATGGTGGCGGTGCTGGTGCCT
TGGGACCTGGGGGAATGGGACAGCTGGTCGGCTCAGAGACGGCCTACTTTACTCACAGCTGGAATTTAGTGGGGAGAAGCAGCTCAACTC
CAATCCTGGAGGATTAGGGAGATTAAAGTGAGAGAAGAGAGAGATGTCCCAGAGACCAAGAGCTCCCAGGTCAGCCCTCTGGCTCCTGGC
ACCCCCACTGCTGCGGTGGGCACCCCCACTCCTCACAGTGCTGCATAGCGACCTCTTCCAGGCCTTGCTGGACATCCTGGACTATTATGA
GGCTTCCCTCTCAGAGAGTCAGAAATACCGCTACCAAGATGAAGACACGCCCCCTCTGGAGCACAGCCCGGCCCACCTCCCCAACCAGGC
CAATTCTCCCCCAGTGATTGTCAACACAGATACCCTAGAAGCCCCAGGATATGAGTTGCAGGTGAACGGGACCGAGGGGGAGATGGAATA
CGAGGAAATCACATTGGAAAGGGGTAACTCAGGTCTGGGCTTCAGCATCGCAGGTGGCACTGACAACCCACACATCGGTGACGACCCATC
CATTTTCATCACCAAGATCATTCCTGGTGGGGCTGCGGCCCAGGATGGCCGCCTCAGGGTCAACGACAGCATCCTGTTTGTAAATGAAGT
GGACGTGCGCGAGGTGACCCACTCAGCGGCGGTGGAAGCCCTCAAAGAGGCAGGCTCCATCGTTCGCCTCTATGTCATGCGCCGGAAGCC
CCCGGCTGAGAAGGTCATGGAGATCAAGCTCATCAAGGGGCCTAAAGGTCTTGGCTTCAGCATCGCAGGGGGCGTAGGGAACCAGCACAT
CCCAGGAGATAATAGCATCTATGTAACAAAGATCATCGAAGGGGGTGCTGCCCACAAGGATGGGAGGTTGCAGATTGGAGACAAGATCCT
GGCGGTCAACAGTGTGGGGCTAGAGGACGTCATGCATGAAGATGCTGTGGCAGCCCTGAAGAACACGTATGATGTTGTCTACCTAAAGGT
GGCCAAGCCCAGCAATGCCTACCTGAGTGACAGCTATGCTCCCCCAGACATCACAACCTGAGAAGACTCTTCCACCTCTTTTTGCCTGAA
TGGCCTTTGGGCACAAGGTCAGAGGCTGGATGTGGACCAGGCCCTGAACAGAAGCCATGAGATCTGGACTCACAGCTGCCCCCAGAGCCC

>In-frame_ENST00000399510_ENST00000575903_TCGA-B5-A0K3_DLG4_chr17_7106221_-_SHBG_chr17_7536521_length(amino acids)=305AA_start in transcript=853_stop in transcript=1770
MSQRPRAPRSALWLLAPPLLRWAPPLLTVLHSDLFQALLDILDYYEASLSESQKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEA
PGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEAL
KEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHED

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DLG4-SHBG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DLG4-SHBG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneDLG4P78352DB00536GuanidineSmall moleculeApproved
HgeneDLG4P78352DB00536GuanidineSmall moleculeApproved

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Related Diseases for DLG4-SHBG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDLG4C0005586Bipolar Disorder4PSYGENET
HgeneDLG4C0041696Unipolar Depression4PSYGENET
HgeneDLG4C1269683Major Depressive Disorder4PSYGENET
HgeneDLG4C0036341Schizophrenia3PSYGENET
HgeneDLG4C0525045Mood Disorders3PSYGENET
HgeneDLG4C0011570Mental Depression1PSYGENET
HgeneDLG4C0011581Depressive disorder1PSYGENET
HgeneDLG4C0032460Polycystic Ovary Syndrome1CTD_human
HgeneDLG4C0175702Williams Syndrome1CTD_human
HgeneDLG4C1136382Sclerocystic Ovaries1CTD_human
HgeneDLG4C1510586Autism Spectrum Disorders1CTD_human
HgeneDLG4C1535926Neurodevelopmental Disorders1CTD_human
HgeneDLG4C1836996Disproportionate tall stature1GENOMICS_ENGLAND
HgeneDLG4C3714756Intellectual Disability1GENOMICS_ENGLAND
TgeneSHBGC0001973Alcoholic Intoxication, Chronic2CTD_human;PSYGENET
TgeneSHBGC0033578Prostatic Neoplasms2CTD_human
TgeneSHBGC0376358Malignant neoplasm of prostate2CTD_human
TgeneSHBGC0524620Metabolic Syndrome X2CTD_human
TgeneSHBGC0001956Alcohol Use Disorder1CTD_human
TgeneSHBGC0007193Cardiomyopathy, Dilated1CTD_human
TgeneSHBGC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneSHBGC0024232Lymphatic Metastasis1CTD_human
TgeneSHBGC0027626Neoplasm Invasiveness1CTD_human
TgeneSHBGC0085762Alcohol abuse1CTD_human
TgeneSHBGC0242350Erectile dysfunction1CTD_human
TgeneSHBGC1449563Cardiomyopathy, Familial Idiopathic1CTD_human