FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:DLL3-SUPT5H (FusionGDB2 ID:23181)

Fusion Gene Summary for DLL3-SUPT5H

check button Fusion gene summary
Fusion gene informationFusion gene name: DLL3-SUPT5H
Fusion gene ID: 23181
HgeneTgene
Gene symbol

DLL3

SUPT5H

Gene ID

10683

6829

Gene namedelta like canonical Notch ligand 3SPT5 homolog, DSIF elongation factor subunit
SynonymsSCDO1SPT5|SPT5H|Tat-CT1
Cytomap

19q13.2

19q13.2

Type of geneprotein-codingprotein-coding
Descriptiondelta-like protein 3delta-like 3delta3drosophila Delta homolog 3transcription elongation factor SPT5DRB sensitivity-inducing factor 160 kDa subunitDRB sensitivity-inducing factor large subunitDSIF large subunitDSIF p160Tat-cotransactivator 1 proteinhSPT5suppressor of Ty 5 homolog
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000356433, ENST00000600579, 
ENST00000205143, 		ENST00000599117, 
ENST00000432763, ENST00000402194, 
ENST00000359191, ENST00000598725, 
Fusion gene scores* DoF score1 X 1 X 1=113 X 11 X 7=1001
# samples 113
** MAII scorelog2(1/1*10)=3.32192809488736log2(13/1001*10)=-2.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DLL3 [Title/Abstract] AND SUPT5H [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDLL3(39998554)-SUPT5H(39943996), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSUPT5H

GO:0000122

negative regulation of transcription by RNA polymerase II

9450929

TgeneSUPT5H

GO:0006368

transcription elongation from RNA polymerase II promoter

9450929

TgeneSUPT5H

GO:0032785

negative regulation of DNA-templated transcription, elongation

9450929

TgeneSUPT5H

GO:0032786

positive regulation of DNA-templated transcription, elongation

9450929

TgeneSUPT5H

GO:0045944

positive regulation of transcription by RNA polymerase II

9450929


check buttonFusion gene breakpoints across DLL3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SUPT5H (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DU-6400-01ADLL3chr19

39998554

+SUPT5Hchr19

39943996

+


Top

Fusion Gene ORF analysis for DLL3-SUPT5H

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000356433ENST00000599117DLL3chr19

39998554

+SUPT5Hchr19

39943996

+
In-frameENST00000356433ENST00000432763DLL3chr19

39998554

+SUPT5Hchr19

39943996

+
In-frameENST00000356433ENST00000402194DLL3chr19

39998554

+SUPT5Hchr19

39943996

+
In-frameENST00000356433ENST00000359191DLL3chr19

39998554

+SUPT5Hchr19

39943996

+
In-frameENST00000356433ENST00000598725DLL3chr19

39998554

+SUPT5Hchr19

39943996

+
intron-3CDSENST00000600579ENST00000599117DLL3chr19

39998554

+SUPT5Hchr19

39943996

+
intron-3CDSENST00000600579ENST00000432763DLL3chr19

39998554

+SUPT5Hchr19

39943996

+
intron-3CDSENST00000600579ENST00000402194DLL3chr19

39998554

+SUPT5Hchr19

39943996

+
intron-3CDSENST00000600579ENST00000359191DLL3chr19

39998554

+SUPT5Hchr19

39943996

+
intron-3CDSENST00000600579ENST00000598725DLL3chr19

39998554

+SUPT5Hchr19

39943996

+
In-frameENST00000205143ENST00000599117DLL3chr19

39998554

+SUPT5Hchr19

39943996

+
In-frameENST00000205143ENST00000432763DLL3chr19

39998554

+SUPT5Hchr19

39943996

+
In-frameENST00000205143ENST00000402194DLL3chr19

39998554

+SUPT5Hchr19

39943996

+
In-frameENST00000205143ENST00000359191DLL3chr19

39998554

+SUPT5Hchr19

39943996

+
In-frameENST00000205143ENST00000598725DLL3chr19

39998554

+SUPT5Hchr19

39943996

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for DLL3-SUPT5H


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DLL3chr1939998554+SUPT5Hchr1939943995+1.16E-091
DLL3chr1939998554+SUPT5Hchr1939943995+1.16E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for DLL3-SUPT5H


check button Go to

FGviewer for the breakpoints of chr19:39998554-chr19:39943996

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDLL3chr19:39998554chr19:39943996ENST00000356433+89176_215586.0588.0DomainNote=DSL
HgeneDLL3chr19:39998554chr19:39943996ENST00000356433+89216_249586.0588.0DomainEGF-like 1
HgeneDLL3chr19:39998554chr19:39943996ENST00000356433+89274_310586.0588.0DomainEGF-like 2
HgeneDLL3chr19:39998554chr19:39943996ENST00000356433+89312_351586.0588.0DomainEGF-like 3
HgeneDLL3chr19:39998554chr19:39943996ENST00000356433+89353_389586.0588.0DomainEGF-like 4
HgeneDLL3chr19:39998554chr19:39943996ENST00000356433+89391_427586.0588.0DomainEGF-like 5
HgeneDLL3chr19:39998554chr19:39943996ENST00000356433+89429_465586.0588.0DomainEGF-like 6
HgeneDLL3chr19:39998554chr19:39943996ENST00000356433+8927_492586.0588.0Topological domainExtracellular
HgeneDLL3chr19:39998554chr19:39943996ENST00000356433+89493_513586.0588.0TransmembraneHelical
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000359191028844_96825.01084.0Compositional biasNote=Pro-rich
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000402194129844_96825.01084.0Compositional biasNote=Pro-rich
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000432763130844_96825.01088.0Compositional biasNote=Pro-rich
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000598725029844_96825.01088.0Compositional biasNote=Pro-rich
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000599117231844_96825.01088.0Compositional biasNote=Pro-rich
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000359191028273_30625.01084.0DomainNote=KOW 1
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000359191028420_45125.01084.0DomainNote=KOW 2
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000359191028472_50325.01084.0DomainNote=KOW 3
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000359191028594_62725.01084.0DomainNote=KOW 4
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000359191028704_73725.01084.0DomainNote=KOW 5
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000402194129273_30625.01084.0DomainNote=KOW 1
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000402194129420_45125.01084.0DomainNote=KOW 2
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000402194129472_50325.01084.0DomainNote=KOW 3
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000402194129594_62725.01084.0DomainNote=KOW 4
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000402194129704_73725.01084.0DomainNote=KOW 5
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000432763130273_30625.01088.0DomainNote=KOW 1
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000432763130420_45125.01088.0DomainNote=KOW 2
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000432763130472_50325.01088.0DomainNote=KOW 3
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000432763130594_62725.01088.0DomainNote=KOW 4
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000432763130704_73725.01088.0DomainNote=KOW 5
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000598725029273_30625.01088.0DomainNote=KOW 1
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000598725029420_45125.01088.0DomainNote=KOW 2
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000598725029472_50325.01088.0DomainNote=KOW 3
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000598725029594_62725.01088.0DomainNote=KOW 4
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000598725029704_73725.01088.0DomainNote=KOW 5
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000599117231273_30625.01088.0DomainNote=KOW 1
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000599117231420_45125.01088.0DomainNote=KOW 2
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000599117231472_50325.01088.0DomainNote=KOW 3
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000599117231594_62725.01088.0DomainNote=KOW 4
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000599117231704_73725.01088.0DomainNote=KOW 5
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000359191028754_81725.01084.0RegionNote=9 X 7 AA approximate tandem repeats of G-S-[QR]-T-P-X-[YQ]%2C motif CTR1
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000359191028844_95025.01084.0RegionNote=10 X 8 AA approximate tandem repeats of P-[TS]-P-S-P-[QA]-[SG]-Y%2C motif CTR2
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000402194129754_81725.01084.0RegionNote=9 X 7 AA approximate tandem repeats of G-S-[QR]-T-P-X-[YQ]%2C motif CTR1
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000402194129844_95025.01084.0RegionNote=10 X 8 AA approximate tandem repeats of P-[TS]-P-S-P-[QA]-[SG]-Y%2C motif CTR2
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000432763130754_81725.01088.0RegionNote=9 X 7 AA approximate tandem repeats of G-S-[QR]-T-P-X-[YQ]%2C motif CTR1
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000432763130844_95025.01088.0RegionNote=10 X 8 AA approximate tandem repeats of P-[TS]-P-S-P-[QA]-[SG]-Y%2C motif CTR2
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000598725029754_81725.01088.0RegionNote=9 X 7 AA approximate tandem repeats of G-S-[QR]-T-P-X-[YQ]%2C motif CTR1
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000598725029844_95025.01088.0RegionNote=10 X 8 AA approximate tandem repeats of P-[TS]-P-S-P-[QA]-[SG]-Y%2C motif CTR2
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000599117231754_81725.01088.0RegionNote=9 X 7 AA approximate tandem repeats of G-S-[QR]-T-P-X-[YQ]%2C motif CTR1
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000599117231844_95025.01088.0RegionNote=10 X 8 AA approximate tandem repeats of P-[TS]-P-S-P-[QA]-[SG]-Y%2C motif CTR2
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000359191028754_75925.01084.0RepeatNote=CTR1-1%3B approximate
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000359191028760_76525.01084.0RepeatNote=CTR1-2
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000359191028766_77125.01084.0RepeatNote=CTR1-3
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000359191028772_77825.01084.0RepeatNote=CTR1-4
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000359191028781_78725.01084.0RepeatNote=CTR1-5
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000359191028788_79425.01084.0RepeatNote=CTR1-6
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000359191028796_80225.01084.0RepeatNote=CTR1-7
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000359191028803_80925.01084.0RepeatNote=CTR1-8
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000359191028811_81725.01084.0RepeatNote=CTR1-9
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000359191028844_85125.01084.0RepeatNote=CTR2-1
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000359191028854_86225.01084.0RepeatNote=CTR2-2%3B approximate
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000359191028863_86925.01084.0RepeatNote=CTR2-3%3B approximate
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000359191028881_88525.01084.0RepeatNote=CTR2-4%3B half-length
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000359191028896_90225.01084.0RepeatNote=CTR2-5%3B approximate
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000359191028904_91125.01084.0RepeatNote=CTR2-6
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000359191028916_92125.01084.0RepeatNote=CTR2-7%3B approximate
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000359191028924_93025.01084.0RepeatNote=CTR2-8
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000359191028932_93925.01084.0RepeatNote=CTR2-9
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000359191028943_95025.01084.0RepeatNote=CTR2-10
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000402194129754_75925.01084.0RepeatNote=CTR1-1%3B approximate
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000402194129760_76525.01084.0RepeatNote=CTR1-2
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000402194129766_77125.01084.0RepeatNote=CTR1-3
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000402194129772_77825.01084.0RepeatNote=CTR1-4
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000402194129781_78725.01084.0RepeatNote=CTR1-5
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000402194129788_79425.01084.0RepeatNote=CTR1-6
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000402194129796_80225.01084.0RepeatNote=CTR1-7
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000402194129803_80925.01084.0RepeatNote=CTR1-8
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000402194129811_81725.01084.0RepeatNote=CTR1-9
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000402194129844_85125.01084.0RepeatNote=CTR2-1
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000402194129854_86225.01084.0RepeatNote=CTR2-2%3B approximate
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000402194129863_86925.01084.0RepeatNote=CTR2-3%3B approximate
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000402194129881_88525.01084.0RepeatNote=CTR2-4%3B half-length
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000402194129896_90225.01084.0RepeatNote=CTR2-5%3B approximate
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000402194129904_91125.01084.0RepeatNote=CTR2-6
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000402194129916_92125.01084.0RepeatNote=CTR2-7%3B approximate
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000402194129924_93025.01084.0RepeatNote=CTR2-8
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000402194129932_93925.01084.0RepeatNote=CTR2-9
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000402194129943_95025.01084.0RepeatNote=CTR2-10
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000432763130754_75925.01088.0RepeatNote=CTR1-1%3B approximate
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000432763130760_76525.01088.0RepeatNote=CTR1-2
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000432763130766_77125.01088.0RepeatNote=CTR1-3
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000432763130772_77825.01088.0RepeatNote=CTR1-4
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000432763130781_78725.01088.0RepeatNote=CTR1-5
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000432763130788_79425.01088.0RepeatNote=CTR1-6
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000432763130796_80225.01088.0RepeatNote=CTR1-7
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000432763130803_80925.01088.0RepeatNote=CTR1-8
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000432763130811_81725.01088.0RepeatNote=CTR1-9
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000432763130844_85125.01088.0RepeatNote=CTR2-1
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000432763130854_86225.01088.0RepeatNote=CTR2-2%3B approximate
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000432763130863_86925.01088.0RepeatNote=CTR2-3%3B approximate
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000432763130881_88525.01088.0RepeatNote=CTR2-4%3B half-length
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000432763130896_90225.01088.0RepeatNote=CTR2-5%3B approximate
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000432763130904_91125.01088.0RepeatNote=CTR2-6
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000432763130916_92125.01088.0RepeatNote=CTR2-7%3B approximate
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000432763130924_93025.01088.0RepeatNote=CTR2-8
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000432763130932_93925.01088.0RepeatNote=CTR2-9
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000432763130943_95025.01088.0RepeatNote=CTR2-10
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000598725029754_75925.01088.0RepeatNote=CTR1-1%3B approximate
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000598725029760_76525.01088.0RepeatNote=CTR1-2
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000598725029766_77125.01088.0RepeatNote=CTR1-3
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000598725029772_77825.01088.0RepeatNote=CTR1-4
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000598725029781_78725.01088.0RepeatNote=CTR1-5
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000598725029788_79425.01088.0RepeatNote=CTR1-6
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000598725029796_80225.01088.0RepeatNote=CTR1-7
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000598725029803_80925.01088.0RepeatNote=CTR1-8
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000598725029811_81725.01088.0RepeatNote=CTR1-9
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000598725029844_85125.01088.0RepeatNote=CTR2-1
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000598725029854_86225.01088.0RepeatNote=CTR2-2%3B approximate
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000598725029863_86925.01088.0RepeatNote=CTR2-3%3B approximate
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000598725029881_88525.01088.0RepeatNote=CTR2-4%3B half-length
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000598725029896_90225.01088.0RepeatNote=CTR2-5%3B approximate
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000598725029904_91125.01088.0RepeatNote=CTR2-6
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000598725029916_92125.01088.0RepeatNote=CTR2-7%3B approximate
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000598725029924_93025.01088.0RepeatNote=CTR2-8
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000598725029932_93925.01088.0RepeatNote=CTR2-9
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000598725029943_95025.01088.0RepeatNote=CTR2-10
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000599117231754_75925.01088.0RepeatNote=CTR1-1%3B approximate
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000599117231760_76525.01088.0RepeatNote=CTR1-2
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000599117231766_77125.01088.0RepeatNote=CTR1-3
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000599117231772_77825.01088.0RepeatNote=CTR1-4
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000599117231781_78725.01088.0RepeatNote=CTR1-5
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000599117231788_79425.01088.0RepeatNote=CTR1-6
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000599117231796_80225.01088.0RepeatNote=CTR1-7
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000599117231803_80925.01088.0RepeatNote=CTR1-8
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000599117231811_81725.01088.0RepeatNote=CTR1-9
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000599117231844_85125.01088.0RepeatNote=CTR2-1
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000599117231854_86225.01088.0RepeatNote=CTR2-2%3B approximate
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000599117231863_86925.01088.0RepeatNote=CTR2-3%3B approximate
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000599117231881_88525.01088.0RepeatNote=CTR2-4%3B half-length
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000599117231896_90225.01088.0RepeatNote=CTR2-5%3B approximate
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000599117231904_91125.01088.0RepeatNote=CTR2-6
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000599117231916_92125.01088.0RepeatNote=CTR2-7%3B approximate
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000599117231924_93025.01088.0RepeatNote=CTR2-8
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000599117231932_93925.01088.0RepeatNote=CTR2-9
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000599117231943_95025.01088.0RepeatNote=CTR2-10

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDLL3chr19:39998554chr19:39943996ENST00000205143+18176_2150619.0DomainNote=DSL
HgeneDLL3chr19:39998554chr19:39943996ENST00000205143+18216_2490619.0DomainEGF-like 1
HgeneDLL3chr19:39998554chr19:39943996ENST00000205143+18274_3100619.0DomainEGF-like 2
HgeneDLL3chr19:39998554chr19:39943996ENST00000205143+18312_3510619.0DomainEGF-like 3
HgeneDLL3chr19:39998554chr19:39943996ENST00000205143+18353_3890619.0DomainEGF-like 4
HgeneDLL3chr19:39998554chr19:39943996ENST00000205143+18391_4270619.0DomainEGF-like 5
HgeneDLL3chr19:39998554chr19:39943996ENST00000205143+18429_4650619.0DomainEGF-like 6
HgeneDLL3chr19:39998554chr19:39943996ENST00000205143+1827_4920619.0Topological domainExtracellular
HgeneDLL3chr19:39998554chr19:39943996ENST00000205143+18514_6180619.0Topological domainCytoplasmic
HgeneDLL3chr19:39998554chr19:39943996ENST00000356433+89514_618586.0588.0Topological domainCytoplasmic
HgeneDLL3chr19:39998554chr19:39943996ENST00000205143+18493_5130619.0TransmembraneHelical
TgeneSUPT5Hchr19:39998554chr19:39943996ENST0000035919102811_10625.01084.0Compositional biasNote=Glu-rich
TgeneSUPT5Hchr19:39998554chr19:39943996ENST0000040219412911_10625.01084.0Compositional biasNote=Glu-rich
TgeneSUPT5Hchr19:39998554chr19:39943996ENST0000043276313011_10625.01088.0Compositional biasNote=Glu-rich
TgeneSUPT5Hchr19:39998554chr19:39943996ENST0000059872502911_10625.01088.0Compositional biasNote=Glu-rich
TgeneSUPT5Hchr19:39998554chr19:39943996ENST0000059911723111_10625.01088.0Compositional biasNote=Glu-rich


Top

Fusion Gene Sequence for DLL3-SUPT5H


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for DLL3-SUPT5H


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000359191028313_42025.01084.0RNA polymerase II
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000402194129313_42025.01084.0RNA polymerase II
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000432763130313_42025.01088.0RNA polymerase II
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000598725029313_42025.01088.0RNA polymerase II
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000599117231313_42025.01088.0RNA polymerase II
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000359191028176_27025.01084.0SUPT4H1
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000402194129176_27025.01084.0SUPT4H1
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000432763130176_27025.01088.0SUPT4H1
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000598725029176_27025.01088.0SUPT4H1
TgeneSUPT5Hchr19:39998554chr19:39943996ENST00000599117231176_27025.01088.0SUPT4H1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for DLL3-SUPT5H


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for DLL3-SUPT5H


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDLL3C0265343Jarcho-Levin syndrome2GENOMICS_ENGLAND;UNIPROT
HgeneDLL3C0000768Congenital Abnormality1CTD_human
HgeneDLL3C0004114Astrocytoma1CTD_human
HgeneDLL3C0013366Dyschondroplasias1CTD_human
HgeneDLL3C0025237Melnick-Needles Syndrome1CTD_human
HgeneDLL3C0026760Multiple Epiphyseal Dysplasia1CTD_human
HgeneDLL3C0029422Osteochondrodysplasias1CTD_human
HgeneDLL3C0036391Schwartz-Jampel Syndrome1CTD_human
HgeneDLL3C0036439Scoliosis, unspecified1CTD_human
HgeneDLL3C0038015Spondyloepiphyseal Dysplasia1CTD_human
HgeneDLL3C0205768Subependymal Giant Cell Astrocytoma1CTD_human
HgeneDLL3C0280783Juvenile Pilocytic Astrocytoma1CTD_human
HgeneDLL3C0280785Diffuse Astrocytoma1CTD_human
HgeneDLL3C0334579Anaplastic astrocytoma1CTD_human
HgeneDLL3C0334580Protoplasmic astrocytoma1CTD_human
HgeneDLL3C0334581Gemistocytic astrocytoma1CTD_human
HgeneDLL3C0334582Fibrillary Astrocytoma1CTD_human
HgeneDLL3C0334583Pilocytic Astrocytoma1CTD_human
HgeneDLL3C0338070Childhood Cerebral Astrocytoma1CTD_human
HgeneDLL3C0376634Craniofacial Abnormalities1CTD_human
HgeneDLL3C0432272Van Buchem disease1CTD_human
HgeneDLL3C0547065Mixed oligoastrocytoma1CTD_human
HgeneDLL3C0750935Cerebral Astrocytoma1CTD_human
HgeneDLL3C0750936Intracranial Astrocytoma1CTD_human
HgeneDLL3C1704230Grade I Astrocytoma1CTD_human
HgeneDLL3C3541456Spondyloepiphyseal Dysplasia Tarda, X-Linked1CTD_human
HgeneDLL3C4551479Schwartz-Jampel Syndrome, Type 11CTD_human