FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:DMXL2-SLC9A1 (FusionGDB2 ID:23270)

Fusion Gene Summary for DMXL2-SLC9A1

check button Fusion gene summary
Fusion gene informationFusion gene name: DMXL2-SLC9A1
Fusion gene ID: 23270
HgeneTgene
Gene symbol

DMXL2

SLC9A1

Gene ID

23312

6548

Gene nameDmx like 2solute carrier family 9 member A1
SynonymsDFNA71|EIEE81|PEPNS|RC3APNH|LIKNS|NHE-1|NHE1|PPP1R143
Cytomap

15q21.2

1p36.11

Type of geneprotein-codingprotein-coding
DescriptiondmX-like protein 2rabconnectin-3sodium/hydrogen exchanger 1Na(+)/H(+) exchanger 1Na-Li countertransporterprotein phosphatase 1, regulatory subunit 143solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive)solute carrier family 9 (sod
Modification date2020031320200313
UniProtAcc

Q8TDJ6

.
Ensembl transtripts involved in fusion geneENST00000251076, ENST00000543779, 
ENST00000449909, ENST00000560421, 
ENST00000263980, ENST00000490329, 
ENST00000545949, ENST00000374086, 
Fusion gene scores* DoF score10 X 8 X 6=4809 X 7 X 7=441
# samples 911
** MAII scorelog2(9/480*10)=-2.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/441*10)=-2.00327513203286
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DMXL2 [Title/Abstract] AND SLC9A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDMXL2(51827860)-SLC9A1(27429803), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSLC9A1

GO:0006883

cellular sodium ion homeostasis

24840010

TgeneSLC9A1

GO:0006885

regulation of pH

8901634

TgeneSLC9A1

GO:0010447

response to acidic pH

8901634

TgeneSLC9A1

GO:0045944

positive regulation of transcription by RNA polymerase II

22688515

TgeneSLC9A1

GO:0051453

regulation of intracellular pH

15035633|24840010

TgeneSLC9A1

GO:0070886

positive regulation of calcineurin-NFAT signaling cascade

22688515

TgeneSLC9A1

GO:0071468

cellular response to acidic pH

24840010

TgeneSLC9A1

GO:0098719

sodium ion import across plasma membrane

24840010

TgeneSLC9A1

GO:1902600

proton transmembrane transport

24840010


check buttonFusion gene breakpoints across DMXL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SLC9A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-A486-01ADMXL2chr15

51827860

-SLC9A1chr1

27429803

-


Top

Fusion Gene ORF analysis for DMXL2-SLC9A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000251076ENST00000263980DMXL2chr15

51827860

-SLC9A1chr1

27429803

-
5CDS-intronENST00000251076ENST00000490329DMXL2chr15

51827860

-SLC9A1chr1

27429803

-
5CDS-intronENST00000251076ENST00000545949DMXL2chr15

51827860

-SLC9A1chr1

27429803

-
5CDS-intronENST00000251076ENST00000374086DMXL2chr15

51827860

-SLC9A1chr1

27429803

-
In-frameENST00000543779ENST00000263980DMXL2chr15

51827860

-SLC9A1chr1

27429803

-
5CDS-intronENST00000543779ENST00000490329DMXL2chr15

51827860

-SLC9A1chr1

27429803

-
5CDS-intronENST00000543779ENST00000545949DMXL2chr15

51827860

-SLC9A1chr1

27429803

-
5CDS-intronENST00000543779ENST00000374086DMXL2chr15

51827860

-SLC9A1chr1

27429803

-
In-frameENST00000449909ENST00000263980DMXL2chr15

51827860

-SLC9A1chr1

27429803

-
5CDS-intronENST00000449909ENST00000490329DMXL2chr15

51827860

-SLC9A1chr1

27429803

-
5CDS-intronENST00000449909ENST00000545949DMXL2chr15

51827860

-SLC9A1chr1

27429803

-
5CDS-intronENST00000449909ENST00000374086DMXL2chr15

51827860

-SLC9A1chr1

27429803

-
intron-3CDSENST00000560421ENST00000263980DMXL2chr15

51827860

-SLC9A1chr1

27429803

-
intron-intronENST00000560421ENST00000490329DMXL2chr15

51827860

-SLC9A1chr1

27429803

-
intron-intronENST00000560421ENST00000545949DMXL2chr15

51827860

-SLC9A1chr1

27429803

-
intron-intronENST00000560421ENST00000374086DMXL2chr15

51827860

-SLC9A1chr1

27429803

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000251076DMXL2chr1551827860-ENST00000263980SLC9A1chr127429803-5179272428836861132
ENST00000543779DMXL2chr1551827860-ENST00000263980SLC9A1chr127429803-498125269034881132
ENST00000449909DMXL2chr1551827860-ENST00000263980SLC9A1chr127429803-498125269034881132

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000251076ENST00000263980DMXL2chr1551827860-SLC9A1chr127429803-0.00122660.9987734
ENST00000543779ENST00000263980DMXL2chr1551827860-SLC9A1chr127429803-0.0008511520.99914885
ENST00000449909ENST00000263980DMXL2chr1551827860-SLC9A1chr127429803-0.0008511520.99914885

Top

Fusion Genomic Features for DMXL2-SLC9A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for DMXL2-SLC9A1


check button Go to

FGviewer for the breakpoints of chr15:51827860-chr1:27429803

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DMXL2

Q8TDJ6

.
FUNCTION: May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity). {ECO:0000250|UniProtKB:Q8BPN8, ECO:0000269|PubMed:11809763}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDMXL2chr15:51827860chr1:27429803ENST00000251076-1343108_145812.03037.0RepeatNote=WD 1
HgeneDMXL2chr15:51827860chr1:27429803ENST00000251076-1343167_207812.03037.0RepeatNote=WD 2
HgeneDMXL2chr15:51827860chr1:27429803ENST00000251076-1343230_278812.03037.0RepeatNote=WD 3
HgeneDMXL2chr15:51827860chr1:27429803ENST00000251076-1343492_532812.03037.0RepeatNote=WD 4
HgeneDMXL2chr15:51827860chr1:27429803ENST00000251076-1343595_634812.03037.0RepeatNote=WD 5
HgeneDMXL2chr15:51827860chr1:27429803ENST00000251076-1343751_803812.03037.0RepeatNote=WD 6
HgeneDMXL2chr15:51827860chr1:27429803ENST00000449909-1341108_145812.02401.0RepeatNote=WD 1
HgeneDMXL2chr15:51827860chr1:27429803ENST00000449909-1341167_207812.02401.0RepeatNote=WD 2
HgeneDMXL2chr15:51827860chr1:27429803ENST00000449909-1341230_278812.02401.0RepeatNote=WD 3
HgeneDMXL2chr15:51827860chr1:27429803ENST00000449909-1341492_532812.02401.0RepeatNote=WD 4
HgeneDMXL2chr15:51827860chr1:27429803ENST00000449909-1341595_634812.02401.0RepeatNote=WD 5
HgeneDMXL2chr15:51827860chr1:27429803ENST00000449909-1341751_803812.02401.0RepeatNote=WD 6
HgeneDMXL2chr15:51827860chr1:27429803ENST00000543779-1343108_145812.03038.0RepeatNote=WD 1
HgeneDMXL2chr15:51827860chr1:27429803ENST00000543779-1343167_207812.03038.0RepeatNote=WD 2
HgeneDMXL2chr15:51827860chr1:27429803ENST00000543779-1343230_278812.03038.0RepeatNote=WD 3
HgeneDMXL2chr15:51827860chr1:27429803ENST00000543779-1343492_532812.03038.0RepeatNote=WD 4
HgeneDMXL2chr15:51827860chr1:27429803ENST00000543779-1343595_634812.03038.0RepeatNote=WD 5
HgeneDMXL2chr15:51827860chr1:27429803ENST00000543779-1343751_803812.03038.0RepeatNote=WD 6
TgeneSLC9A1chr15:51827860chr1:27429803ENST0000037408605382_4020556.0IntramembraneName%3DH10
TgeneSLC9A1chr15:51827860chr1:27429803ENST00000263980412500_815495.0816.0Topological domainCytoplasmic
TgeneSLC9A1chr15:51827860chr1:27429803ENST0000037408605128_1290556.0Topological domainCytoplasmic
TgeneSLC9A1chr15:51827860chr1:27429803ENST0000037408605150_1540556.0Topological domainExtracellular
TgeneSLC9A1chr15:51827860chr1:27429803ENST0000037408605175_1910556.0Topological domainCytoplasmic
TgeneSLC9A1chr15:51827860chr1:27429803ENST00000374086051_120556.0Topological domainCytoplasmic
TgeneSLC9A1chr15:51827860chr1:27429803ENST0000037408605212_2270556.0Topological domainExtracellular
TgeneSLC9A1chr15:51827860chr1:27429803ENST0000037408605248_2560556.0Topological domainCytoplasmic
TgeneSLC9A1chr15:51827860chr1:27429803ENST0000037408605277_2940556.0Topological domainExtracellular
TgeneSLC9A1chr15:51827860chr1:27429803ENST0000037408605316_3380556.0Topological domainCytoplasmic
TgeneSLC9A1chr15:51827860chr1:27429803ENST000003740860534_1050556.0Topological domainExtracellular
TgeneSLC9A1chr15:51827860chr1:27429803ENST0000037408605359_3810556.0Topological domainExtracellular
TgeneSLC9A1chr15:51827860chr1:27429803ENST0000037408605403_4100556.0Topological domainExtracellular
TgeneSLC9A1chr15:51827860chr1:27429803ENST0000037408605431_4480556.0Topological domainCytoplasmic
TgeneSLC9A1chr15:51827860chr1:27429803ENST0000037408605471_4790556.0Topological domainExtracellular
TgeneSLC9A1chr15:51827860chr1:27429803ENST0000037408605500_8150556.0Topological domainCytoplasmic
TgeneSLC9A1chr15:51827860chr1:27429803ENST0000037408605106_1270556.0TransmembraneHelical%3B Name%3DM2
TgeneSLC9A1chr15:51827860chr1:27429803ENST0000037408605130_1490556.0TransmembraneHelical%3B Name%3DM3
TgeneSLC9A1chr15:51827860chr1:27429803ENST000003740860513_330556.0TransmembraneHelical%3B Name%3DM1
TgeneSLC9A1chr15:51827860chr1:27429803ENST0000037408605155_1740556.0TransmembraneHelical%3B Name%3DM4
TgeneSLC9A1chr15:51827860chr1:27429803ENST0000037408605192_2110556.0TransmembraneHelical%3B Name%3DM5
TgeneSLC9A1chr15:51827860chr1:27429803ENST0000037408605228_2470556.0TransmembraneHelical%3B Name%3DM6
TgeneSLC9A1chr15:51827860chr1:27429803ENST0000037408605257_2760556.0TransmembraneHelical%3B Name%3DM7
TgeneSLC9A1chr15:51827860chr1:27429803ENST0000037408605295_3150556.0TransmembraneHelical%3B Name%3DM8
TgeneSLC9A1chr15:51827860chr1:27429803ENST0000037408605339_3580556.0TransmembraneHelical%3B Name%3DM9
TgeneSLC9A1chr15:51827860chr1:27429803ENST0000037408605411_4300556.0TransmembraneHelical%3B Name%3DM10
TgeneSLC9A1chr15:51827860chr1:27429803ENST0000037408605449_4700556.0TransmembraneHelical%3B Name%3DM11
TgeneSLC9A1chr15:51827860chr1:27429803ENST0000037408605480_4990556.0TransmembraneHelical%3B Name%3DM12

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDMXL2chr15:51827860chr1:27429803ENST00000251076-13432122_2153812.03037.0Coiled coilOntology_term=ECO:0000255
HgeneDMXL2chr15:51827860chr1:27429803ENST00000449909-13412122_2153812.02401.0Coiled coilOntology_term=ECO:0000255
HgeneDMXL2chr15:51827860chr1:27429803ENST00000543779-13432122_2153812.03038.0Coiled coilOntology_term=ECO:0000255
HgeneDMXL2chr15:51827860chr1:27429803ENST00000251076-13431000_1037812.03037.0RepeatNote=WD 8
HgeneDMXL2chr15:51827860chr1:27429803ENST00000251076-13431163_1204812.03037.0RepeatNote=WD 9
HgeneDMXL2chr15:51827860chr1:27429803ENST00000251076-13431244_1281812.03037.0RepeatNote=WD 10
HgeneDMXL2chr15:51827860chr1:27429803ENST00000251076-13432761_2800812.03037.0RepeatNote=WD 11
HgeneDMXL2chr15:51827860chr1:27429803ENST00000251076-13432804_2843812.03037.0RepeatNote=WD 12
HgeneDMXL2chr15:51827860chr1:27429803ENST00000251076-13432850_2892812.03037.0RepeatNote=WD 13
HgeneDMXL2chr15:51827860chr1:27429803ENST00000251076-13432898_2937812.03037.0RepeatNote=WD 14
HgeneDMXL2chr15:51827860chr1:27429803ENST00000251076-13432940_2979812.03037.0RepeatNote=WD 15
HgeneDMXL2chr15:51827860chr1:27429803ENST00000251076-13432992_3030812.03037.0RepeatNote=WD 16
HgeneDMXL2chr15:51827860chr1:27429803ENST00000251076-1343878_920812.03037.0RepeatNote=WD 7
HgeneDMXL2chr15:51827860chr1:27429803ENST00000449909-13411000_1037812.02401.0RepeatNote=WD 8
HgeneDMXL2chr15:51827860chr1:27429803ENST00000449909-13411163_1204812.02401.0RepeatNote=WD 9
HgeneDMXL2chr15:51827860chr1:27429803ENST00000449909-13411244_1281812.02401.0RepeatNote=WD 10
HgeneDMXL2chr15:51827860chr1:27429803ENST00000449909-13412761_2800812.02401.0RepeatNote=WD 11
HgeneDMXL2chr15:51827860chr1:27429803ENST00000449909-13412804_2843812.02401.0RepeatNote=WD 12
HgeneDMXL2chr15:51827860chr1:27429803ENST00000449909-13412850_2892812.02401.0RepeatNote=WD 13
HgeneDMXL2chr15:51827860chr1:27429803ENST00000449909-13412898_2937812.02401.0RepeatNote=WD 14
HgeneDMXL2chr15:51827860chr1:27429803ENST00000449909-13412940_2979812.02401.0RepeatNote=WD 15
HgeneDMXL2chr15:51827860chr1:27429803ENST00000449909-13412992_3030812.02401.0RepeatNote=WD 16
HgeneDMXL2chr15:51827860chr1:27429803ENST00000449909-1341878_920812.02401.0RepeatNote=WD 7
HgeneDMXL2chr15:51827860chr1:27429803ENST00000543779-13431000_1037812.03038.0RepeatNote=WD 8
HgeneDMXL2chr15:51827860chr1:27429803ENST00000543779-13431163_1204812.03038.0RepeatNote=WD 9
HgeneDMXL2chr15:51827860chr1:27429803ENST00000543779-13431244_1281812.03038.0RepeatNote=WD 10
HgeneDMXL2chr15:51827860chr1:27429803ENST00000543779-13432761_2800812.03038.0RepeatNote=WD 11
HgeneDMXL2chr15:51827860chr1:27429803ENST00000543779-13432804_2843812.03038.0RepeatNote=WD 12
HgeneDMXL2chr15:51827860chr1:27429803ENST00000543779-13432850_2892812.03038.0RepeatNote=WD 13
HgeneDMXL2chr15:51827860chr1:27429803ENST00000543779-13432898_2937812.03038.0RepeatNote=WD 14
HgeneDMXL2chr15:51827860chr1:27429803ENST00000543779-13432940_2979812.03038.0RepeatNote=WD 15
HgeneDMXL2chr15:51827860chr1:27429803ENST00000543779-13432992_3030812.03038.0RepeatNote=WD 16
HgeneDMXL2chr15:51827860chr1:27429803ENST00000543779-1343878_920812.03038.0RepeatNote=WD 7
TgeneSLC9A1chr15:51827860chr1:27429803ENST00000263980412382_402495.0816.0IntramembraneName%3DH10
TgeneSLC9A1chr15:51827860chr1:27429803ENST00000263980412128_129495.0816.0Topological domainCytoplasmic
TgeneSLC9A1chr15:51827860chr1:27429803ENST00000263980412150_154495.0816.0Topological domainExtracellular
TgeneSLC9A1chr15:51827860chr1:27429803ENST00000263980412175_191495.0816.0Topological domainCytoplasmic
TgeneSLC9A1chr15:51827860chr1:27429803ENST000002639804121_12495.0816.0Topological domainCytoplasmic
TgeneSLC9A1chr15:51827860chr1:27429803ENST00000263980412212_227495.0816.0Topological domainExtracellular
TgeneSLC9A1chr15:51827860chr1:27429803ENST00000263980412248_256495.0816.0Topological domainCytoplasmic
TgeneSLC9A1chr15:51827860chr1:27429803ENST00000263980412277_294495.0816.0Topological domainExtracellular
TgeneSLC9A1chr15:51827860chr1:27429803ENST00000263980412316_338495.0816.0Topological domainCytoplasmic
TgeneSLC9A1chr15:51827860chr1:27429803ENST0000026398041234_105495.0816.0Topological domainExtracellular
TgeneSLC9A1chr15:51827860chr1:27429803ENST00000263980412359_381495.0816.0Topological domainExtracellular
TgeneSLC9A1chr15:51827860chr1:27429803ENST00000263980412403_410495.0816.0Topological domainExtracellular
TgeneSLC9A1chr15:51827860chr1:27429803ENST00000263980412431_448495.0816.0Topological domainCytoplasmic
TgeneSLC9A1chr15:51827860chr1:27429803ENST00000263980412471_479495.0816.0Topological domainExtracellular
TgeneSLC9A1chr15:51827860chr1:27429803ENST00000263980412106_127495.0816.0TransmembraneHelical%3B Name%3DM2
TgeneSLC9A1chr15:51827860chr1:27429803ENST00000263980412130_149495.0816.0TransmembraneHelical%3B Name%3DM3
TgeneSLC9A1chr15:51827860chr1:27429803ENST0000026398041213_33495.0816.0TransmembraneHelical%3B Name%3DM1
TgeneSLC9A1chr15:51827860chr1:27429803ENST00000263980412155_174495.0816.0TransmembraneHelical%3B Name%3DM4
TgeneSLC9A1chr15:51827860chr1:27429803ENST00000263980412192_211495.0816.0TransmembraneHelical%3B Name%3DM5
TgeneSLC9A1chr15:51827860chr1:27429803ENST00000263980412228_247495.0816.0TransmembraneHelical%3B Name%3DM6
TgeneSLC9A1chr15:51827860chr1:27429803ENST00000263980412257_276495.0816.0TransmembraneHelical%3B Name%3DM7
TgeneSLC9A1chr15:51827860chr1:27429803ENST00000263980412295_315495.0816.0TransmembraneHelical%3B Name%3DM8
TgeneSLC9A1chr15:51827860chr1:27429803ENST00000263980412339_358495.0816.0TransmembraneHelical%3B Name%3DM9
TgeneSLC9A1chr15:51827860chr1:27429803ENST00000263980412411_430495.0816.0TransmembraneHelical%3B Name%3DM10
TgeneSLC9A1chr15:51827860chr1:27429803ENST00000263980412449_470495.0816.0TransmembraneHelical%3B Name%3DM11
TgeneSLC9A1chr15:51827860chr1:27429803ENST00000263980412480_499495.0816.0TransmembraneHelical%3B Name%3DM12


Top

Fusion Gene Sequence for DMXL2-SLC9A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000251076_ENST00000263980_TCGA-CD-A486-01A_DMXL2_chr15_51827860_-_SLC9A1_chr1_27429803_length(transcript)=5179nt_BP=2724nt
ACAAGCACCCTTGCCCTCCCGCATTTGTGCGCCGGTGCAGCAGGCAGTGGGAACATCCGGGCATTTCCGCAGCTGAGCGGCGACCCGGGC
GGCGGCGGCGGTCGAGGAGCTCCCATGGCAGGGACGAGGCGGAGGGAAGGCGAAAGGGGGGCGAGGAGTTAAGCCAGAGCCTCCGCGGGG
CGGGTTTCCGAGGGAGGCACAGAGGGAAACGGCTCTCGCAGCCCGAGGAGGGTCAGGCGCGGAGCTTGTCGCACCTCCCGCGCATTCTGT
CCAGCCCGGGCTCCGGAGATGCATCTGCATCAGGTCCTCACCGGAGCTGTCAACCCTGGAGACAACTGCTACTCCGTGGGCAGCGTCGGG
GATGTCCCCTTCACGGCATATGGATCAGGCTGTGATATTGTTATTTTGGCAAATGACTTTGAATGTGTACAGATCATTCCTGGTGCTAAG
CATGGAAACATCCAAGTCAGCTGTGTGGAGTGTTCTAACCAACAAGGAAGAATTGCAGCTTCATATGGTAATGCTGTTTGTATATTTGAG
CCCTTGGGCATAAATTCTCATAAAAGAAATTGTCAACTCAAGTGCCAGTGGCTTAAAACTGGGCAGTTTTTTTTGAGTTCTGTGACATAC
AACTTAGCATGGGATCCTCAAGATAATAGATTGTTGACAGCAACTGATTCTATTCAGTTGTGGGCTCCTCCAGGAGATGATATTCTGGAA
GAGGAGGAAGAAATTGATAATACAGTTCCTCCTGTTTTAAATGATTGGAAGTGTGTCTGGCAGTGCAAAACCTCAGTATCTGTACATTTG
ATGGAATGGTCTCCTGATGGTGAATATTTTGCTACTGCTGGAAAGGATGATTGTCTTTTGAAAGTGTGGTATCCTATGACTGGTTGGAAG
TCTTCAATTATACCTCAGGATCATCATGAAGTAAAAAGGAGACAGTCCTCTACTCAATTTTCTTTTGTTTACTTGGCACATCCCCGAGCT
GTGACAGGTTTTTCGTGGCGCAAAACTAGCAAGTATATGCCCAGGGGTTCTGTCTGTAATGTGTTGTTAACTTCATGTCATGATGGTGTG
TGCCGGCTCTGGGCAGAAACTTTATTACCAGAAGACTGTCTTTTGGGTGAGCAGATTTGTGAGACTACCACTTCCAGCATTGCCAGCAGC
CTTTCTCATGCTGGAAGACACAAAGACAGAATACAGCATGCTCTTGAGACAATACACCATTTGAAAAATTTAAGGAAAGGACAGAGGAGG
TCATCTGTTCTTGTAACTCATGCTGAATTAATGCCCGACCAGACAGCAATGCATGAAGTTCAAAGACACATTTCCCACCATGCAAATGCA
CTCTGTCATTTTCATATTGCAGCAAGCATCAACCCTGCCACAGATATTCCAAATGTCTTGGTTGGCACTGCATTTAATGTTGATGATGGA
AATGGGGGCTTTGTAGTTCATTGGTTAAACAACAAGGAATTTCATTTTACATCATCTACAGAAGTATTTATGCATCAATTACGAAAACTT
TCTGATAAGCAGGTAGATCATGAAAATGATGATGCAGATAGAGAAGATGAGGAACATTCACAGGAGGATAGAGAACGGGGTTTACATATG
AAATTAGACCATGATTTATCCCTGGATAGAGAATCTGAGGCAGGTACAGGATCATCAGAACATGAAGATGGAGAAAGAGAAGGAAGTCCT
AGAACTTACTCACGACTTAGTGTACCAATGCCACTGCCTACGGTTCTGCTTGATCGGAAGATTGAAACGCTGCTAACTGAATGGAATAAG
AATCCTGATATGCTTTTTACAATACACCCTGTAGATGGTACCTTTCTAGTGTGGCATGTGAAGTATTTGGATGAATATAATCCTGGAATA
TTTAGACAAGTTCAGGTTTCTTTTTCTTCTCGGATTCCTGTTGCATTTCCCTCTGGTGATGCAAGCTCTCTTAGTAAAAATATCATGATG
TATGCCTGTATAAATGCGACAAAAGATTCTCACCACACGCTGTTACACCAGGAGGGGATGTCTGTAGGCAGTCCTCACGGATCACAGCCA
CACTCTAGATCCCACAGTACACATATGAACATCTTAGCTCCCACAGTAATGATGATCTCTAAACACATAGATGGTTCTTTAAATCAGTGG
GCAGTCACTTTTGCTGATAAGTCTGCCTTTACCACTGTTCTAACTGTATCTCACAAATTTAGATATTGCGGTCATCGATTTCACCTCAAT
GACCTGGCATGTCATTCAGTTTTACCACTGTTATTGACATCCTCTCATCATAATGCTCTATTGACTCCTGAATTAGATTGTCAGTGGGAC
TCAGACAATAAATTAAGTAGATTAATGGACCCTGTAAAACATATAAAAGGTTCCTCGAAACAACCTCTTAGAAATGCAGCAACTCGTACA
TTTCATGACCCAAATGCAATCTACAGTGAACTTATTCTGTGGCGTGTAGACCCAATAGGACCTTTGTCATACACTGGAGGAGTATCAGAA
TTGGCTCGAATTAACTCTTTACATACCTCAGCGTTCTCTAATGTGGCTTGGCTTCCAACTCTCATTCCCAGTTACTGTCTAGGCACATAC
TGCAATTCTGCAAGTGCTTGCTTTGTTGCTTCTGATGGCAAAAATCTGAGACTCTATCAAGCTGTAGTGGATGCAAGGAAATTATTAGAT
GAATTGTCAGACCCAGAATCTTCAGGCATGACCATTCGGCCCCTGGTAGACCTGTTGGCTGTGAAGAAAAAGCAAGAGACGAAGCGCTCC
ATCAACGAAGAGATCCACACACAGTTCCTGGACCACCTTCTGACAGGCATCGAAGACATCTGTGGCCACTACGGTCACCACCACTGGAAG
GACAAGCTCAACCGGTTTAATAAGAAATATGTGAAGAAGTGTCTGATAGCTGGCGAGCGCTCCAAGGAGCCCCAGCTCATTGCCTTCTAC
CACAAGATGGAGATGAAGCAGGCCATCGAGCTGGTGGAGAGCGGGGGCATGGGCAAGATCCCCTCTGCCGTCTCCACCGTCTCCATGCAG
AACATCCACCCCAAGTCCCTGCCTTCCGAGCGCATCCTGCCAGCACTGTCCAAGGACAAGGAGGAGGAGATCCGCAAAATCCTGAGGAAC
AACTTGCAGAAGACCAGGCAGCGGCTGCGGTCCTACAACAGACACACGCTGGTGGCAGACCCCTACGAGGAAGCCTGGAACCAGATGCTG
CTCCGGAGGCAGAAGGCCCGGCAGCTGGAGCAGAAGATCAACAACTACCTGACGGTGCCAGCCCACAAGCTGGACTCACCCACCATGTCT
CGGGCCCGCATCGGCTCAGACCCACTGGCCTATGAGCCGAAGGAGGACCTGCCTGTCATCACCATCGACCCGGCTTCCCCGCAGTCACCC
GAGTCTGTGGACCTGGTGAATGAAGAGCTGAAGGGCAAAGTCTTAGGGTTGAGCCGGGATCCTGCAAAGGTGGCTGAGGAGGACGAGGAC
GACGATGGGGGCATCATGATGCGGAGCAAGGAGACTTCGTCCCCAGGAACCGACGATGTCTTCACCCCCGCGCCCAGTGACAGCCCCAGC
TCCCAGAGGATACAGCGCTGCCTCAGTGACCCAGGCCCACACCCTGAGCCTGGGGAGGGAGAACCGTTCTTCCCCAAGGGGCAGTAACAC
CAGGGCCAGCAGGCAGCGCCTGTCCCCTCACAGACTCTTCCACCAGAGCAGGGGCTGCTGGGGGCTCCCCTTGCCCTTCCTGACCCGGAT
TGGCCCTGCCCCTCCCCCTACCGCATGGCAGCTGGGCCCACAGCCCCCACCCCAGCACAGCTCCTCCCCTGCCGCCTCCCGGGAAGCATC
CTCCCCACCAGAGCTGCCTCCCCAATCCATTTGGCAGAACTGCTGGGGCTGGTGAGGCCGGCCCTGCCCCTCCCTAGATCCAGGCTTCTC
CCGGACCTGGACTAGGGCCTCGGAGGCTCCTCCCTCTGCCTCATCCTCCTCCTCATTCAGACCAATCTTAGTTTCTAACCAAAGAGTCTC
TGGCTCAGCTGTGGTCCCACCCAGGAAGGGAGGGAGCTGAGGCCTCCCTTGAGTAGGCCCTGCTTTATCAGGGGACAAACCAGGGGTACC
AGGCACATGGCTGGGGGAGGGACTGCTGACCCACCAAGGTCTCACACTCCTCCTGCCAGCTCTGTCACCCTGGCCACCACCCAACCTGTC
CTTACTCAGAGCTGCGGGCTGAGGGCATCTCTGAGTGTCTCTGCCTGGAGCAGGGGTGGTTTCTACGGTGACAGTGACGTGACTCAGAGC
TTTTCGAACTGTGCTCCCACGGGGACCACTGGGCCCCTCAGGGGAAGCTGCTAGGGGAAGGACTGGCCGTGGCTCCAGAATGTGCTGCCT
TTTTAAGTTTTGTTTGTTCACACTCCTATATATGATTGTTTGCACAGAGGGCGCTCCTGTTTTTAAAACATTTTGAAAACCCCTGGCTGA
ACAGTGCTCTGCCTCTAACTCCCTCCTCACACTCCAGAATTACCCTTCCTCATCTGTGCCTGTCTGTCCAACCCCTCCCCCACGTCTCTC
TGCCTGCTGGGCTCTTAACTGTTGCTCGAAGACTGTGACATCAGAAGTAACTCCCACTCCTAATCAAGAGTCTCTCCAGCCTCACAGATG
CTGGCCTCTTGGCACCTGCCTAGCTCTTGGGCCTGACCTCCAGTCCTGCTGGCCTGCTCTTACTTCCCCCACCCTGGGTTTGGCCCCTGG
AACCTTTCCCTTGTGTGTACCACACCCTGCCTGCTGTGGAGCCCATTGTGGAGGCGGTGGGGGGGAGAAGGCCTCCCCTGAGGATCCCCT
GTCCCCTGGGGCTGGTGGATTGGGCAGAATCCTGGGCCCCCAGAGACCTTTGCCCACACACACTCCTTCCCCTTGTCCCTGGGGCACTCC
CCCAGGATTGTGCAATAGTCAGAGTGTCCCTTTTTGCAGGGGACTGGGCCATGGGTCCTCGGCCCATCTGTCCATCCTCCTCTCCATGCA
AGTGCTGTTTGGGCAGGAGTCACCATGCAAGGGTGACATCGACAACCACGTACCAAGCCACCGCAGCTGCTGCCACTCTGCTGCCTGTAC

>In-frame_ENST00000251076_ENST00000263980_TCGA-CD-A486-01A_DMXL2_chr15_51827860_-_SLC9A1_chr1_27429803_length(amino acids)=1132AA_start in transcript=288_stop in transcript=3686
MHLHQVLTGAVNPGDNCYSVGSVGDVPFTAYGSGCDIVILANDFECVQIIPGAKHGNIQVSCVECSNQQGRIAASYGNAVCIFEPLGINS
HKRNCQLKCQWLKTGQFFLSSVTYNLAWDPQDNRLLTATDSIQLWAPPGDDILEEEEEIDNTVPPVLNDWKCVWQCKTSVSVHLMEWSPD
GEYFATAGKDDCLLKVWYPMTGWKSSIIPQDHHEVKRRQSSTQFSFVYLAHPRAVTGFSWRKTSKYMPRGSVCNVLLTSCHDGVCRLWAE
TLLPEDCLLGEQICETTTSSIASSLSHAGRHKDRIQHALETIHHLKNLRKGQRRSSVLVTHAELMPDQTAMHEVQRHISHHANALCHFHI
AASINPATDIPNVLVGTAFNVDDGNGGFVVHWLNNKEFHFTSSTEVFMHQLRKLSDKQVDHENDDADREDEEHSQEDRERGLHMKLDHDL
SLDRESEAGTGSSEHEDGEREGSPRTYSRLSVPMPLPTVLLDRKIETLLTEWNKNPDMLFTIHPVDGTFLVWHVKYLDEYNPGIFRQVQV
SFSSRIPVAFPSGDASSLSKNIMMYACINATKDSHHTLLHQEGMSVGSPHGSQPHSRSHSTHMNILAPTVMMISKHIDGSLNQWAVTFAD
KSAFTTVLTVSHKFRYCGHRFHLNDLACHSVLPLLLTSSHHNALLTPELDCQWDSDNKLSRLMDPVKHIKGSSKQPLRNAATRTFHDPNA
IYSELILWRVDPIGPLSYTGGVSELARINSLHTSAFSNVAWLPTLIPSYCLGTYCNSASACFVASDGKNLRLYQAVVDARKLLDELSDPE
SSGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMK
QAIELVESGGMGKIPSAVSTVSMQNIHPKSLPSERILPALSKDKEEEIRKILRNNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKA
RQLEQKINNYLTVPAHKLDSPTMSRARIGSDPLAYEPKEDLPVITIDPASPQSPESVDLVNEELKGKVLGLSRDPAKVAEEDEDDDGGIM

--------------------------------------------------------------
>In-frame_ENST00000543779_ENST00000263980_TCGA-CD-A486-01A_DMXL2_chr15_51827860_-_SLC9A1_chr1_27429803_length(transcript)=4981nt_BP=2526nt
ACAGAGGGAAACGGCTCTCGCAGCCCGAGGAGGGTCAGGCGCGGAGCTTGTCGCACCTCCCGCGCATTCTGTCCAGCCCGGGCTCCGGAG
ATGCATCTGCATCAGGTCCTCACCGGAGCTGTCAACCCTGGAGACAACTGCTACTCCGTGGGCAGCGTCGGGGATGTCCCCTTCACGGCA
TATGGATCAGGCTGTGATATTGTTATTTTGGCAAATGACTTTGAATGTGTACAGATCATTCCTGGTGCTAAGCATGGAAACATCCAAGTC
AGCTGTGTGGAGTGTTCTAACCAACAAGGAAGAATTGCAGCTTCATATGGTAATGCTGTTTGTATATTTGAGCCCTTGGGCATAAATTCT
CATAAAAGAAATTGTCAACTCAAGTGCCAGTGGCTTAAAACTGGGCAGTTTTTTTTGAGTTCTGTGACATACAACTTAGCATGGGATCCT
CAAGATAATAGATTGTTGACAGCAACTGATTCTATTCAGTTGTGGGCTCCTCCAGGAGATGATATTCTGGAAGAGGAGGAAGAAATTGAT
AATACAGTTCCTCCTGTTTTAAATGATTGGAAGTGTGTCTGGCAGTGCAAAACCTCAGTATCTGTACATTTGATGGAATGGTCTCCTGAT
GGTGAATATTTTGCTACTGCTGGAAAGGATGATTGTCTTTTGAAAGTGTGGTATCCTATGACTGGTTGGAAGTCTTCAATTATACCTCAG
GATCATCATGAAGTAAAAAGGAGACAGTCCTCTACTCAATTTTCTTTTGTTTACTTGGCACATCCCCGAGCTGTGACAGGTTTTTCGTGG
CGCAAAACTAGCAAGTATATGCCCAGGGGTTCTGTCTGTAATGTGTTGTTAACTTCATGTCATGATGGTGTGTGCCGGCTCTGGGCAGAA
ACTTTATTACCAGAAGACTGTCTTTTGGGTGAGCAGATTTGTGAGACTACCACTTCCAGCATTGCCAGCAGCCTTTCTCATGCTGGAAGA
CACAAAGACAGAATACAGCATGCTCTTGAGACAATACACCATTTGAAAAATTTAAGGAAAGGACAGAGGAGGTCATCTGTTCTTGTAACT
CATGCTGAATTAATGCCCGACCAGACAGCAATGCATGAAGTTCAAAGACACATTTCCCACCATGCAAATGCACTCTGTCATTTTCATATT
GCAGCAAGCATCAACCCTGCCACAGATATTCCAAATGTCTTGGTTGGCACTGCATTTAATGTTGATGATGGAAATGGGGGCTTTGTAGTT
CATTGGTTAAACAACAAGGAATTTCATTTTACATCATCTACAGAAGTATTTATGCATCAATTACGAAAACTTTCTGATAAGCAGGTAGAT
CATGAAAATGATGATGCAGATAGAGAAGATGAGGAACATTCACAGGAGGATAGAGAACGGGGTTTACATATGAAATTAGACCATGATTTA
TCCCTGGATAGAGAATCTGAGGCAGGTACAGGATCATCAGAACATGAAGATGGAGAAAGAGAAGGAAGTCCTAGAACTTACTCACGACTT
AGTGTACCAATGCCACTGCCTACGGTTCTGCTTGATCGGAAGATTGAAACGCTGCTAACTGAATGGAATAAGAATCCTGATATGCTTTTT
ACAATACACCCTGTAGATGGTACCTTTCTAGTGTGGCATGTGAAGTATTTGGATGAATATAATCCTGGAATATTTAGACAAGTTCAGGTT
TCTTTTTCTTCTCGGATTCCTGTTGCATTTCCCTCTGGTGATGCAAGCTCTCTTAGTAAAAATATCATGATGTATGCCTGTATAAATGCG
ACAAAAGATTCTCACCACACGCTGTTACACCAGGAGGGGATGTCTGTAGGCAGTCCTCACGGATCACAGCCACACTCTAGATCCCACAGT
ACACATATGAACATCTTAGCTCCCACAGTAATGATGATCTCTAAACACATAGATGGTTCTTTAAATCAGTGGGCAGTCACTTTTGCTGAT
AAGTCTGCCTTTACCACTGTTCTAACTGTATCTCACAAATTTAGATATTGCGGTCATCGATTTCACCTCAATGACCTGGCATGTCATTCA
GTTTTACCACTGTTATTGACATCCTCTCATCATAATGCTCTATTGACTCCTGAATTAGATTGTCAGTGGGACTCAGACAATAAATTAAGT
AGATTAATGGACCCTGTAAAACATATAAAAGGTTCCTCGAAACAACCTCTTAGAAATGCAGCAACTCGTACATTTCATGACCCAAATGCA
ATCTACAGTGAACTTATTCTGTGGCGTGTAGACCCAATAGGACCTTTGTCATACACTGGAGGAGTATCAGAATTGGCTCGAATTAACTCT
TTACATACCTCAGCGTTCTCTAATGTGGCTTGGCTTCCAACTCTCATTCCCAGTTACTGTCTAGGCACATACTGCAATTCTGCAAGTGCT
TGCTTTGTTGCTTCTGATGGCAAAAATCTGAGACTCTATCAAGCTGTAGTGGATGCAAGGAAATTATTAGATGAATTGTCAGACCCAGAA
TCTTCAGGCATGACCATTCGGCCCCTGGTAGACCTGTTGGCTGTGAAGAAAAAGCAAGAGACGAAGCGCTCCATCAACGAAGAGATCCAC
ACACAGTTCCTGGACCACCTTCTGACAGGCATCGAAGACATCTGTGGCCACTACGGTCACCACCACTGGAAGGACAAGCTCAACCGGTTT
AATAAGAAATATGTGAAGAAGTGTCTGATAGCTGGCGAGCGCTCCAAGGAGCCCCAGCTCATTGCCTTCTACCACAAGATGGAGATGAAG
CAGGCCATCGAGCTGGTGGAGAGCGGGGGCATGGGCAAGATCCCCTCTGCCGTCTCCACCGTCTCCATGCAGAACATCCACCCCAAGTCC
CTGCCTTCCGAGCGCATCCTGCCAGCACTGTCCAAGGACAAGGAGGAGGAGATCCGCAAAATCCTGAGGAACAACTTGCAGAAGACCAGG
CAGCGGCTGCGGTCCTACAACAGACACACGCTGGTGGCAGACCCCTACGAGGAAGCCTGGAACCAGATGCTGCTCCGGAGGCAGAAGGCC
CGGCAGCTGGAGCAGAAGATCAACAACTACCTGACGGTGCCAGCCCACAAGCTGGACTCACCCACCATGTCTCGGGCCCGCATCGGCTCA
GACCCACTGGCCTATGAGCCGAAGGAGGACCTGCCTGTCATCACCATCGACCCGGCTTCCCCGCAGTCACCCGAGTCTGTGGACCTGGTG
AATGAAGAGCTGAAGGGCAAAGTCTTAGGGTTGAGCCGGGATCCTGCAAAGGTGGCTGAGGAGGACGAGGACGACGATGGGGGCATCATG
ATGCGGAGCAAGGAGACTTCGTCCCCAGGAACCGACGATGTCTTCACCCCCGCGCCCAGTGACAGCCCCAGCTCCCAGAGGATACAGCGC
TGCCTCAGTGACCCAGGCCCACACCCTGAGCCTGGGGAGGGAGAACCGTTCTTCCCCAAGGGGCAGTAACACCAGGGCCAGCAGGCAGCG
CCTGTCCCCTCACAGACTCTTCCACCAGAGCAGGGGCTGCTGGGGGCTCCCCTTGCCCTTCCTGACCCGGATTGGCCCTGCCCCTCCCCC
TACCGCATGGCAGCTGGGCCCACAGCCCCCACCCCAGCACAGCTCCTCCCCTGCCGCCTCCCGGGAAGCATCCTCCCCACCAGAGCTGCC
TCCCCAATCCATTTGGCAGAACTGCTGGGGCTGGTGAGGCCGGCCCTGCCCCTCCCTAGATCCAGGCTTCTCCCGGACCTGGACTAGGGC
CTCGGAGGCTCCTCCCTCTGCCTCATCCTCCTCCTCATTCAGACCAATCTTAGTTTCTAACCAAAGAGTCTCTGGCTCAGCTGTGGTCCC
ACCCAGGAAGGGAGGGAGCTGAGGCCTCCCTTGAGTAGGCCCTGCTTTATCAGGGGACAAACCAGGGGTACCAGGCACATGGCTGGGGGA
GGGACTGCTGACCCACCAAGGTCTCACACTCCTCCTGCCAGCTCTGTCACCCTGGCCACCACCCAACCTGTCCTTACTCAGAGCTGCGGG
CTGAGGGCATCTCTGAGTGTCTCTGCCTGGAGCAGGGGTGGTTTCTACGGTGACAGTGACGTGACTCAGAGCTTTTCGAACTGTGCTCCC
ACGGGGACCACTGGGCCCCTCAGGGGAAGCTGCTAGGGGAAGGACTGGCCGTGGCTCCAGAATGTGCTGCCTTTTTAAGTTTTGTTTGTT
CACACTCCTATATATGATTGTTTGCACAGAGGGCGCTCCTGTTTTTAAAACATTTTGAAAACCCCTGGCTGAACAGTGCTCTGCCTCTAA
CTCCCTCCTCACACTCCAGAATTACCCTTCCTCATCTGTGCCTGTCTGTCCAACCCCTCCCCCACGTCTCTCTGCCTGCTGGGCTCTTAA
CTGTTGCTCGAAGACTGTGACATCAGAAGTAACTCCCACTCCTAATCAAGAGTCTCTCCAGCCTCACAGATGCTGGCCTCTTGGCACCTG
CCTAGCTCTTGGGCCTGACCTCCAGTCCTGCTGGCCTGCTCTTACTTCCCCCACCCTGGGTTTGGCCCCTGGAACCTTTCCCTTGTGTGT
ACCACACCCTGCCTGCTGTGGAGCCCATTGTGGAGGCGGTGGGGGGGAGAAGGCCTCCCCTGAGGATCCCCTGTCCCCTGGGGCTGGTGG
ATTGGGCAGAATCCTGGGCCCCCAGAGACCTTTGCCCACACACACTCCTTCCCCTTGTCCCTGGGGCACTCCCCCAGGATTGTGCAATAG
TCAGAGTGTCCCTTTTTGCAGGGGACTGGGCCATGGGTCCTCGGCCCATCTGTCCATCCTCCTCTCCATGCAAGTGCTGTTTGGGCAGGA
GTCACCATGCAAGGGTGACATCGACAACCACGTACCAAGCCACCGCAGCTGCTGCCACTCTGCTGCCTGTACAGAAGAAACTGAATCTTT

>In-frame_ENST00000543779_ENST00000263980_TCGA-CD-A486-01A_DMXL2_chr15_51827860_-_SLC9A1_chr1_27429803_length(amino acids)=1132AA_start in transcript=90_stop in transcript=3488
MHLHQVLTGAVNPGDNCYSVGSVGDVPFTAYGSGCDIVILANDFECVQIIPGAKHGNIQVSCVECSNQQGRIAASYGNAVCIFEPLGINS
HKRNCQLKCQWLKTGQFFLSSVTYNLAWDPQDNRLLTATDSIQLWAPPGDDILEEEEEIDNTVPPVLNDWKCVWQCKTSVSVHLMEWSPD
GEYFATAGKDDCLLKVWYPMTGWKSSIIPQDHHEVKRRQSSTQFSFVYLAHPRAVTGFSWRKTSKYMPRGSVCNVLLTSCHDGVCRLWAE
TLLPEDCLLGEQICETTTSSIASSLSHAGRHKDRIQHALETIHHLKNLRKGQRRSSVLVTHAELMPDQTAMHEVQRHISHHANALCHFHI
AASINPATDIPNVLVGTAFNVDDGNGGFVVHWLNNKEFHFTSSTEVFMHQLRKLSDKQVDHENDDADREDEEHSQEDRERGLHMKLDHDL
SLDRESEAGTGSSEHEDGEREGSPRTYSRLSVPMPLPTVLLDRKIETLLTEWNKNPDMLFTIHPVDGTFLVWHVKYLDEYNPGIFRQVQV
SFSSRIPVAFPSGDASSLSKNIMMYACINATKDSHHTLLHQEGMSVGSPHGSQPHSRSHSTHMNILAPTVMMISKHIDGSLNQWAVTFAD
KSAFTTVLTVSHKFRYCGHRFHLNDLACHSVLPLLLTSSHHNALLTPELDCQWDSDNKLSRLMDPVKHIKGSSKQPLRNAATRTFHDPNA
IYSELILWRVDPIGPLSYTGGVSELARINSLHTSAFSNVAWLPTLIPSYCLGTYCNSASACFVASDGKNLRLYQAVVDARKLLDELSDPE
SSGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMK
QAIELVESGGMGKIPSAVSTVSMQNIHPKSLPSERILPALSKDKEEEIRKILRNNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKA
RQLEQKINNYLTVPAHKLDSPTMSRARIGSDPLAYEPKEDLPVITIDPASPQSPESVDLVNEELKGKVLGLSRDPAKVAEEDEDDDGGIM

--------------------------------------------------------------
>In-frame_ENST00000449909_ENST00000263980_TCGA-CD-A486-01A_DMXL2_chr15_51827860_-_SLC9A1_chr1_27429803_length(transcript)=4981nt_BP=2526nt
ACAGAGGGAAACGGCTCTCGCAGCCCGAGGAGGGTCAGGCGCGGAGCTTGTCGCACCTCCCGCGCATTCTGTCCAGCCCGGGCTCCGGAG
ATGCATCTGCATCAGGTCCTCACCGGAGCTGTCAACCCTGGAGACAACTGCTACTCCGTGGGCAGCGTCGGGGATGTCCCCTTCACGGCA
TATGGATCAGGCTGTGATATTGTTATTTTGGCAAATGACTTTGAATGTGTACAGATCATTCCTGGTGCTAAGCATGGAAACATCCAAGTC
AGCTGTGTGGAGTGTTCTAACCAACAAGGAAGAATTGCAGCTTCATATGGTAATGCTGTTTGTATATTTGAGCCCTTGGGCATAAATTCT
CATAAAAGAAATTGTCAACTCAAGTGCCAGTGGCTTAAAACTGGGCAGTTTTTTTTGAGTTCTGTGACATACAACTTAGCATGGGATCCT
CAAGATAATAGATTGTTGACAGCAACTGATTCTATTCAGTTGTGGGCTCCTCCAGGAGATGATATTCTGGAAGAGGAGGAAGAAATTGAT
AATACAGTTCCTCCTGTTTTAAATGATTGGAAGTGTGTCTGGCAGTGCAAAACCTCAGTATCTGTACATTTGATGGAATGGTCTCCTGAT
GGTGAATATTTTGCTACTGCTGGAAAGGATGATTGTCTTTTGAAAGTGTGGTATCCTATGACTGGTTGGAAGTCTTCAATTATACCTCAG
GATCATCATGAAGTAAAAAGGAGACAGTCCTCTACTCAATTTTCTTTTGTTTACTTGGCACATCCCCGAGCTGTGACAGGTTTTTCGTGG
CGCAAAACTAGCAAGTATATGCCCAGGGGTTCTGTCTGTAATGTGTTGTTAACTTCATGTCATGATGGTGTGTGCCGGCTCTGGGCAGAA
ACTTTATTACCAGAAGACTGTCTTTTGGGTGAGCAGATTTGTGAGACTACCACTTCCAGCATTGCCAGCAGCCTTTCTCATGCTGGAAGA
CACAAAGACAGAATACAGCATGCTCTTGAGACAATACACCATTTGAAAAATTTAAGGAAAGGACAGAGGAGGTCATCTGTTCTTGTAACT
CATGCTGAATTAATGCCCGACCAGACAGCAATGCATGAAGTTCAAAGACACATTTCCCACCATGCAAATGCACTCTGTCATTTTCATATT
GCAGCAAGCATCAACCCTGCCACAGATATTCCAAATGTCTTGGTTGGCACTGCATTTAATGTTGATGATGGAAATGGGGGCTTTGTAGTT
CATTGGTTAAACAACAAGGAATTTCATTTTACATCATCTACAGAAGTATTTATGCATCAATTACGAAAACTTTCTGATAAGCAGGTAGAT
CATGAAAATGATGATGCAGATAGAGAAGATGAGGAACATTCACAGGAGGATAGAGAACGGGGTTTACATATGAAATTAGACCATGATTTA
TCCCTGGATAGAGAATCTGAGGCAGGTACAGGATCATCAGAACATGAAGATGGAGAAAGAGAAGGAAGTCCTAGAACTTACTCACGACTT
AGTGTACCAATGCCACTGCCTACGGTTCTGCTTGATCGGAAGATTGAAACGCTGCTAACTGAATGGAATAAGAATCCTGATATGCTTTTT
ACAATACACCCTGTAGATGGTACCTTTCTAGTGTGGCATGTGAAGTATTTGGATGAATATAATCCTGGAATATTTAGACAAGTTCAGGTT
TCTTTTTCTTCTCGGATTCCTGTTGCATTTCCCTCTGGTGATGCAAGCTCTCTTAGTAAAAATATCATGATGTATGCCTGTATAAATGCG
ACAAAAGATTCTCACCACACGCTGTTACACCAGGAGGGGATGTCTGTAGGCAGTCCTCACGGATCACAGCCACACTCTAGATCCCACAGT
ACACATATGAACATCTTAGCTCCCACAGTAATGATGATCTCTAAACACATAGATGGTTCTTTAAATCAGTGGGCAGTCACTTTTGCTGAT
AAGTCTGCCTTTACCACTGTTCTAACTGTATCTCACAAATTTAGATATTGCGGTCATCGATTTCACCTCAATGACCTGGCATGTCATTCA
GTTTTACCACTGTTATTGACATCCTCTCATCATAATGCTCTATTGACTCCTGAATTAGATTGTCAGTGGGACTCAGACAATAAATTAAGT
AGATTAATGGACCCTGTAAAACATATAAAAGGTTCCTCGAAACAACCTCTTAGAAATGCAGCAACTCGTACATTTCATGACCCAAATGCA
ATCTACAGTGAACTTATTCTGTGGCGTGTAGACCCAATAGGACCTTTGTCATACACTGGAGGAGTATCAGAATTGGCTCGAATTAACTCT
TTACATACCTCAGCGTTCTCTAATGTGGCTTGGCTTCCAACTCTCATTCCCAGTTACTGTCTAGGCACATACTGCAATTCTGCAAGTGCT
TGCTTTGTTGCTTCTGATGGCAAAAATCTGAGACTCTATCAAGCTGTAGTGGATGCAAGGAAATTATTAGATGAATTGTCAGACCCAGAA
TCTTCAGGCATGACCATTCGGCCCCTGGTAGACCTGTTGGCTGTGAAGAAAAAGCAAGAGACGAAGCGCTCCATCAACGAAGAGATCCAC
ACACAGTTCCTGGACCACCTTCTGACAGGCATCGAAGACATCTGTGGCCACTACGGTCACCACCACTGGAAGGACAAGCTCAACCGGTTT
AATAAGAAATATGTGAAGAAGTGTCTGATAGCTGGCGAGCGCTCCAAGGAGCCCCAGCTCATTGCCTTCTACCACAAGATGGAGATGAAG
CAGGCCATCGAGCTGGTGGAGAGCGGGGGCATGGGCAAGATCCCCTCTGCCGTCTCCACCGTCTCCATGCAGAACATCCACCCCAAGTCC
CTGCCTTCCGAGCGCATCCTGCCAGCACTGTCCAAGGACAAGGAGGAGGAGATCCGCAAAATCCTGAGGAACAACTTGCAGAAGACCAGG
CAGCGGCTGCGGTCCTACAACAGACACACGCTGGTGGCAGACCCCTACGAGGAAGCCTGGAACCAGATGCTGCTCCGGAGGCAGAAGGCC
CGGCAGCTGGAGCAGAAGATCAACAACTACCTGACGGTGCCAGCCCACAAGCTGGACTCACCCACCATGTCTCGGGCCCGCATCGGCTCA
GACCCACTGGCCTATGAGCCGAAGGAGGACCTGCCTGTCATCACCATCGACCCGGCTTCCCCGCAGTCACCCGAGTCTGTGGACCTGGTG
AATGAAGAGCTGAAGGGCAAAGTCTTAGGGTTGAGCCGGGATCCTGCAAAGGTGGCTGAGGAGGACGAGGACGACGATGGGGGCATCATG
ATGCGGAGCAAGGAGACTTCGTCCCCAGGAACCGACGATGTCTTCACCCCCGCGCCCAGTGACAGCCCCAGCTCCCAGAGGATACAGCGC
TGCCTCAGTGACCCAGGCCCACACCCTGAGCCTGGGGAGGGAGAACCGTTCTTCCCCAAGGGGCAGTAACACCAGGGCCAGCAGGCAGCG
CCTGTCCCCTCACAGACTCTTCCACCAGAGCAGGGGCTGCTGGGGGCTCCCCTTGCCCTTCCTGACCCGGATTGGCCCTGCCCCTCCCCC
TACCGCATGGCAGCTGGGCCCACAGCCCCCACCCCAGCACAGCTCCTCCCCTGCCGCCTCCCGGGAAGCATCCTCCCCACCAGAGCTGCC
TCCCCAATCCATTTGGCAGAACTGCTGGGGCTGGTGAGGCCGGCCCTGCCCCTCCCTAGATCCAGGCTTCTCCCGGACCTGGACTAGGGC
CTCGGAGGCTCCTCCCTCTGCCTCATCCTCCTCCTCATTCAGACCAATCTTAGTTTCTAACCAAAGAGTCTCTGGCTCAGCTGTGGTCCC
ACCCAGGAAGGGAGGGAGCTGAGGCCTCCCTTGAGTAGGCCCTGCTTTATCAGGGGACAAACCAGGGGTACCAGGCACATGGCTGGGGGA
GGGACTGCTGACCCACCAAGGTCTCACACTCCTCCTGCCAGCTCTGTCACCCTGGCCACCACCCAACCTGTCCTTACTCAGAGCTGCGGG
CTGAGGGCATCTCTGAGTGTCTCTGCCTGGAGCAGGGGTGGTTTCTACGGTGACAGTGACGTGACTCAGAGCTTTTCGAACTGTGCTCCC
ACGGGGACCACTGGGCCCCTCAGGGGAAGCTGCTAGGGGAAGGACTGGCCGTGGCTCCAGAATGTGCTGCCTTTTTAAGTTTTGTTTGTT
CACACTCCTATATATGATTGTTTGCACAGAGGGCGCTCCTGTTTTTAAAACATTTTGAAAACCCCTGGCTGAACAGTGCTCTGCCTCTAA
CTCCCTCCTCACACTCCAGAATTACCCTTCCTCATCTGTGCCTGTCTGTCCAACCCCTCCCCCACGTCTCTCTGCCTGCTGGGCTCTTAA
CTGTTGCTCGAAGACTGTGACATCAGAAGTAACTCCCACTCCTAATCAAGAGTCTCTCCAGCCTCACAGATGCTGGCCTCTTGGCACCTG
CCTAGCTCTTGGGCCTGACCTCCAGTCCTGCTGGCCTGCTCTTACTTCCCCCACCCTGGGTTTGGCCCCTGGAACCTTTCCCTTGTGTGT
ACCACACCCTGCCTGCTGTGGAGCCCATTGTGGAGGCGGTGGGGGGGAGAAGGCCTCCCCTGAGGATCCCCTGTCCCCTGGGGCTGGTGG
ATTGGGCAGAATCCTGGGCCCCCAGAGACCTTTGCCCACACACACTCCTTCCCCTTGTCCCTGGGGCACTCCCCCAGGATTGTGCAATAG
TCAGAGTGTCCCTTTTTGCAGGGGACTGGGCCATGGGTCCTCGGCCCATCTGTCCATCCTCCTCTCCATGCAAGTGCTGTTTGGGCAGGA
GTCACCATGCAAGGGTGACATCGACAACCACGTACCAAGCCACCGCAGCTGCTGCCACTCTGCTGCCTGTACAGAAGAAACTGAATCTTT

>In-frame_ENST00000449909_ENST00000263980_TCGA-CD-A486-01A_DMXL2_chr15_51827860_-_SLC9A1_chr1_27429803_length(amino acids)=1132AA_start in transcript=90_stop in transcript=3488
MHLHQVLTGAVNPGDNCYSVGSVGDVPFTAYGSGCDIVILANDFECVQIIPGAKHGNIQVSCVECSNQQGRIAASYGNAVCIFEPLGINS
HKRNCQLKCQWLKTGQFFLSSVTYNLAWDPQDNRLLTATDSIQLWAPPGDDILEEEEEIDNTVPPVLNDWKCVWQCKTSVSVHLMEWSPD
GEYFATAGKDDCLLKVWYPMTGWKSSIIPQDHHEVKRRQSSTQFSFVYLAHPRAVTGFSWRKTSKYMPRGSVCNVLLTSCHDGVCRLWAE
TLLPEDCLLGEQICETTTSSIASSLSHAGRHKDRIQHALETIHHLKNLRKGQRRSSVLVTHAELMPDQTAMHEVQRHISHHANALCHFHI
AASINPATDIPNVLVGTAFNVDDGNGGFVVHWLNNKEFHFTSSTEVFMHQLRKLSDKQVDHENDDADREDEEHSQEDRERGLHMKLDHDL
SLDRESEAGTGSSEHEDGEREGSPRTYSRLSVPMPLPTVLLDRKIETLLTEWNKNPDMLFTIHPVDGTFLVWHVKYLDEYNPGIFRQVQV
SFSSRIPVAFPSGDASSLSKNIMMYACINATKDSHHTLLHQEGMSVGSPHGSQPHSRSHSTHMNILAPTVMMISKHIDGSLNQWAVTFAD
KSAFTTVLTVSHKFRYCGHRFHLNDLACHSVLPLLLTSSHHNALLTPELDCQWDSDNKLSRLMDPVKHIKGSSKQPLRNAATRTFHDPNA
IYSELILWRVDPIGPLSYTGGVSELARINSLHTSAFSNVAWLPTLIPSYCLGTYCNSASACFVASDGKNLRLYQAVVDARKLLDELSDPE
SSGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMK
QAIELVESGGMGKIPSAVSTVSMQNIHPKSLPSERILPALSKDKEEEIRKILRNNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKA
RQLEQKINNYLTVPAHKLDSPTMSRARIGSDPLAYEPKEDLPVITIDPASPQSPESVDLVNEELKGKVLGLSRDPAKVAEEDEDDDGGIM

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for DMXL2-SLC9A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneSLC9A1chr15:51827860chr1:27429803ENST00000263980412515_545495.0816.0CHP2
TgeneSLC9A1chr15:51827860chr1:27429803ENST0000037408605515_5450556.0CHP2
TgeneSLC9A1chr15:51827860chr1:27429803ENST00000263980412633_815495.0816.0TESC
TgeneSLC9A1chr15:51827860chr1:27429803ENST0000037408605633_8150556.0TESC
TgeneSLC9A1chr15:51827860chr1:27429803ENST00000263980412503_545495.0816.0TESC
TgeneSLC9A1chr15:51827860chr1:27429803ENST0000037408605503_5450556.0TESC


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for DMXL2-SLC9A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for DMXL2-SLC9A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDMXL2C0018784Sensorineural Hearing Loss (disorder)4GENOMICS_ENGLAND
HgeneDMXL2C4015261POLYENDOCRINE-POLYNEUROPATHY SYNDROME3GENOMICS_ENGLAND;ORPHANET
HgeneDMXL2C1846647DEAFNESS, AUTOSOMAL RECESSIVE (disorder)2CLINGEN
HgeneDMXL2C4539881DEAFNESS, AUTOSOMAL DOMINANT 711UNIPROT
TgeneSLC9A1C4225383LICHTENSTEIN-KNORR SYNDROME2CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneSLC9A1C0002152Alloxan Diabetes1CTD_human
TgeneSLC9A1C0004763Barrett Esophagus1CTD_human
TgeneSLC9A1C0007194Hypertrophic Cardiomyopathy1CTD_human
TgeneSLC9A1C0011853Diabetes Mellitus, Experimental1CTD_human
TgeneSLC9A1C0013604Edema1CTD_human
TgeneSLC9A1C0018801Heart failure1CTD_human
TgeneSLC9A1C0018802Congestive heart failure1CTD_human
TgeneSLC9A1C0023212Left-Sided Heart Failure1CTD_human
TgeneSLC9A1C0030193Pain1CTD_human
TgeneSLC9A1C0035126Reperfusion Injury1CTD_human
TgeneSLC9A1C0036982Shock, Hemorrhagic1CTD_human
TgeneSLC9A1C0038433Streptozotocin Diabetes1CTD_human
TgeneSLC9A1C0151603Anasarca1CTD_human
TgeneSLC9A1C0234230Pain, Burning1CTD_human
TgeneSLC9A1C0234238Ache1CTD_human
TgeneSLC9A1C0234254Radiating pain1CTD_human
TgeneSLC9A1C0235527Heart Failure, Right-Sided1CTD_human
TgeneSLC9A1C0458257Pain, Splitting1CTD_human
TgeneSLC9A1C0458259Pain, Crushing1CTD_human
TgeneSLC9A1C0600519Ventricular Remodeling1CTD_human
TgeneSLC9A1C0600520Left Ventricle Remodeling1CTD_human
TgeneSLC9A1C0751407Pain, Migratory1CTD_human
TgeneSLC9A1C0751408Suffering, Physical1CTD_human
TgeneSLC9A1C1258085Barrett Epithelium1CTD_human
TgeneSLC9A1C1959583Myocardial Failure1CTD_human
TgeneSLC9A1C1961112Heart Decompensation1CTD_human
TgeneSLC9A1C4551472Hypertrophic obstructive cardiomyopathy1CTD_human