|
Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:ADCY2-HSDL2 (FusionGDB2 ID:2335) |
Fusion Gene Summary for ADCY2-HSDL2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: ADCY2-HSDL2 | Fusion gene ID: 2335 | Hgene | Tgene | Gene symbol | ADCY2 | HSDL2 | Gene ID | 108 | 84263 |
Gene name | adenylate cyclase 2 | hydroxysteroid dehydrogenase like 2 | |
Synonyms | AC2|HBAC2 | C9orf99|SDR13C1 | |
Cytomap | 5p15.31 | 9q32 | |
Type of gene | protein-coding | protein-coding | |
Description | adenylate cyclase type 23',5'-cyclic AMP synthetaseATP pyrophosphate-lyase 2adenylate cyclase 2 (brain)adenylate cyclase IIadenylate cyclase type IIadenylyl cyclase 2type II adenylate cyclase | hydroxysteroid dehydrogenase-like protein 2short chain dehydrogenase/reductase family 13C member 1 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q08462 | Q6YN16 | |
Ensembl transtripts involved in fusion gene | ENST00000338316, ENST00000537121, ENST00000513693, | ENST00000398805, ENST00000398803, ENST00000488101, ENST00000262542, ENST00000539114, | |
Fusion gene scores | * DoF score | 11 X 9 X 6=594 | 6 X 6 X 6=216 |
# samples | 10 | 7 | |
** MAII score | log2(10/594*10)=-2.57046293102604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/216*10)=-1.6256044852185 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ADCY2 [Title/Abstract] AND HSDL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ADCY2(7773214)-HSDL2(115179121), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene breakpoints across ADCY2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across HSDL2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | SARC | TCGA-DX-A1KZ-01A | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
Top |
Fusion Gene ORF analysis for ADCY2-HSDL2 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000338316 | ENST00000398805 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
5CDS-intron | ENST00000338316 | ENST00000398803 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
5CDS-3UTR | ENST00000338316 | ENST00000488101 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
5CDS-3UTR | ENST00000338316 | ENST00000262542 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
5CDS-intron | ENST00000338316 | ENST00000539114 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
In-frame | ENST00000537121 | ENST00000398805 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
5CDS-intron | ENST00000537121 | ENST00000398803 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
5CDS-3UTR | ENST00000537121 | ENST00000488101 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
5CDS-3UTR | ENST00000537121 | ENST00000262542 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
5CDS-intron | ENST00000537121 | ENST00000539114 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
intron-3CDS | ENST00000513693 | ENST00000398805 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
intron-intron | ENST00000513693 | ENST00000398803 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
intron-3UTR | ENST00000513693 | ENST00000488101 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
intron-3UTR | ENST00000513693 | ENST00000262542 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
intron-intron | ENST00000513693 | ENST00000539114 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000338316 | ADCY2 | chr5 | 7773214 | + | ENST00000398805 | HSDL2 | chr9 | 115179121 | + | 5201 | 2473 | 89 | 3334 | 1081 |
ENST00000537121 | ADCY2 | chr5 | 7773214 | + | ENST00000398805 | HSDL2 | chr9 | 115179121 | + | 4638 | 1910 | 66 | 2771 | 901 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000338316 | ENST00000398805 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + | 0.00027331 | 0.9997267 |
ENST00000537121 | ENST00000398805 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + | 0.000238572 | 0.9997614 |
Top |
Fusion Genomic Features for ADCY2-HSDL2 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179120 | + | 9.67E-06 | 0.99999034 |
ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179120 | + | 9.67E-06 | 0.99999034 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
Top |
Fusion Protein Features for ADCY2-HSDL2 |
Go to FGviewer for the breakpoints of chr5:7773214-chr9:115179121 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
ADCY2 | HSDL2 |
FUNCTION: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity). {ECO:0000250|UniProtKB:P26769, ECO:0000269|PubMed:15385642}. | FUNCTION: Has apparently no steroid dehydrogenase activity. {ECO:0000269|PubMed:19703561}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 295_300 | 794.6666666666666 | 1092.0 | Nucleotide binding | ATP |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 337_339 | 794.6666666666666 | 1092.0 | Nucleotide binding | ATP |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 1_45 | 794.6666666666666 | 1092.0 | Topological domain | Cytoplasmic |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 208_601 | 794.6666666666666 | 1092.0 | Topological domain | Cytoplasmic |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 108_128 | 794.6666666666666 | 1092.0 | Transmembrane | Helical |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 133_153 | 794.6666666666666 | 1092.0 | Transmembrane | Helical |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 159_179 | 794.6666666666666 | 1092.0 | Transmembrane | Helical |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 187_207 | 794.6666666666666 | 1092.0 | Transmembrane | Helical |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 46_66 | 794.6666666666666 | 1092.0 | Transmembrane | Helical |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 602_622 | 794.6666666666666 | 1092.0 | Transmembrane | Helical |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 628_652 | 794.6666666666666 | 1092.0 | Transmembrane | Helical |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 680_701 | 794.6666666666666 | 1092.0 | Transmembrane | Helical |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 734_755 | 794.6666666666666 | 1092.0 | Transmembrane | Helical |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 763_780 | 794.6666666666666 | 1092.0 | Transmembrane | Helical |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 76_96 | 794.6666666666666 | 1092.0 | Transmembrane | Helical |
Tgene | HSDL2 | chr5:7773214 | chr9:115179121 | ENST00000398803 | 0 | 9 | 306_415 | 0 | 346.0 | Domain | Note=SCP2 | |
Tgene | HSDL2 | chr5:7773214 | chr9:115179121 | ENST00000398805 | 3 | 11 | 306_415 | 131.66666666666666 | 419.0 | Domain | Note=SCP2 | |
Tgene | HSDL2 | chr5:7773214 | chr9:115179121 | ENST00000398803 | 0 | 9 | 17_23 | 0 | 346.0 | Nucleotide binding | NADP |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 1019_1021 | 794.6666666666666 | 1092.0 | Nucleotide binding | ATP |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 1026_1030 | 794.6666666666666 | 1092.0 | Nucleotide binding | ATP |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 822_1091 | 794.6666666666666 | 1092.0 | Topological domain | Cytoplasmic |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 801_821 | 794.6666666666666 | 1092.0 | Transmembrane | Helical |
Tgene | HSDL2 | chr5:7773214 | chr9:115179121 | ENST00000398805 | 3 | 11 | 17_23 | 131.66666666666666 | 419.0 | Nucleotide binding | NADP |
Top |
Fusion Gene Sequence for ADCY2-HSDL2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000338316_ENST00000398805_TCGA-DX-A1KZ-01A_ADCY2_chr5_7773214_+_HSDL2_chr9_115179121_length(transcript)=5201nt_BP=2473nt AGGCGGCGCGGGGGTGGGACGCGGGCGGCCGCGGCGAGCGGCGCTGCCCGGGCCGGGCGCGCACGGCGGGCGCCCTGTGAGCGGCCCCGA TGTGGCAGGAGGCGATGCGGCGCCGCCGCTACCTGCGGGACCGCTCCGAGGAGGCGGCGGGCGGCGGAGACGGGCTGCCGCGGTCCCGGG ACTGGCTCTACGAGTCCTACTACTGCATGAGCCAGCAGCACCCGCTCATCGTCTTCCTGCTGCTCATCGTCATGGGCTCCTGCCTCGCCC TGCTCGCCGTCTTCTTCGCGCTCGGGCTGGAAGTTGAAGACCATGTGGCGTTTCTAATAACAGTTCCAACTGCCCTGGCGATTTTCTTTG CGATATTTATCCTGGTCTGCATCGAGTCTGTGTTTAAGAAGCTGCTGCGCCTCTTCTCGTTGGTGATATGGATATGCCTTGTTGCCATGG GATACCTGTTCATGTGTTTTGGAGGCACCGTCTCTCCCTGGGACCAGGTATCGTTCTTCCTCTTCATCATCTTCGTGGTGTACACCATGC TGCCCTTCAACATGCGAGACGCCATCATTGCCAGCGTCCTCACCTCCTCCTCCCACACCATCGTGCTTAGCGTCTGCCTGTCTGCAACAC CGGGAGGCAAGGAGCACCTGGTCTGGCAGATCCTGGCCAATGTGATCATTTTCATCTGTGGGAACCTGGCGGGAGCCTACCATAAGCACC TCATGGAACTCGCTCTTCAGCAAACATATCAGGACACCTGTAATTGCATCAAGTCGCGGATCAAGTTGGAATTTGAAAAACGTCAACAGG AGCGGCTTCTGCTCTCCCTGCTGCCGGCCCACATCGCCATGGAGATGAAAGCGGAGATCATCCAGAGGCTGCAGGGCCCCAAGGCGGGCC AGATGGAGAACACAAATAACTTCCACAACCTGTATGTGAAGCGGCATACAAACGTGAGCATCTTATACGCTGACATCGTTGGCTTTACCC GGCTGGCAAGTGACTGCTCCCCGGGAGAACTAGTCCACATGCTGAATGAGCTCTTTGGAAAGTTTGATCAAATTGCAAAGGAGAATGAAT GCATGAGAATTAAAATTTTAGGAGACTGCTACTACTGTGTATCTGGACTCCCTATATCTCTCCCTAACCATGCCAAGAACTGTGTGAAAA TGGGGCTGGACATGTGTGAAGCCATAAAGAAAGTGAGGGATGCTACTGGAGTTGATATCAACATGCGCGTGGGCGTGCATTCTGGGAATG TCCTGTGTGGCGTGATTGGTCTGCAGAAGTGGCAATATGATGTGTGGTCACATGATGTGACCTTGGCCAACCACATGGAAGCTGGAGGGG TCCCTGGACGTGTTCACATTTCTTCTGTCACCCTGGAGCACTTGAATGGCGCTTATAAAGTGGAGGAGGGAGATGGTGACATTAGGGACC CATATTTAAAACAGCACCTGGTGAAAACCTACTTTGTGATCAACCCCAAGGGAGAACGACGGAGCCCCCAGCATCTCTTCAGACCTCGCC ACACCCTTGATGGAGCCAAAATGAGGGCCTCGGTCCGCATGACCCGGTACTTGGAGTCCTGGGGGGCAGCCAAGCCCTTTGCACACCTAC ATCACAGGGACAGCATGACCACAGAGAACGGCAAGATCAGCACCACGGATGTACCCATGGGTCAGCATAATTTTCAAAATCGCACCTTAA GAACCAAGTCACAAAAGAAGAGATTTGAAGAAGAATTGAATGAAAGGATGATTCAAGCAATTGATGGGATTAATGCACAGAAGCAATGGC TCAAGTCTGAAGACATTCAGAGAATCTCACTGCTTTTCTATAACAAAGTACTAGAAAAAGAGTACCGGGCCACGGCACTGCCAGCGTTCA AGTATTATGTGACTTGTGCCTGTCTCATATTCTTCTGCATCTTCATTGTGCAGATTCTCGTGCTGCCAAAAACGTCCGTCCTGGGCATCT CCTTTGGGGCTGCGTTTCTCTTGCTGGCCTTCATCCTCTTCGTCTGCTTTGCTGGACAGCTTCTGCAATGCAGCAAAAAAGCCTCTCCCC TGCTCATGTGGCTTTTGAAGTCCTCGGGCATCATTGCCAACCGCCCCTGGCCACGGATCTCTCTCACGATCATCACCACAGCCATCATAT TAATGATGGCCGTGTTCAACATGTTTTTCCTGAGTGACTCAGAGGAAACAATCCCTCCAACTGCCAACACAACAAACACAAGCTTTTCAG CCTCAAATAATCAGGTGGCGATTCTGCGTGCGCAGAATTTATTTTTCCTCCCGTACTTTATCTACAGCTGCATTCTGGGACTGATATCCT GTTCCGTGTTCCTGCGGGTAAACTATGAGCTGAAGATGTTGATCATGATGGTGGCCTTGGTGGGCTACAACACCATCCTACTCCACACCC ACGCCCACGTCCTGGGCGACTACAGCCAGGTCTTATTTGAGAGATCTAAAGCATGTATTCCTTATTTGAAAAAGAGCAAAGTTGCTCATA TCCTCAATATCAGTCCACCACTGAACCTAAATCCAGTTTGGTTCAAACAGCACTGTGCTTATACCATTGCTAAGTATGGTATGTCTATGT ATGTGCTTGGAATGGCAGAAGAATTTAAAGGTGAAATTGCAGTCAATGCATTATGGCCTAAAACAGCCATACACACTGCTGCTATGGATA TGCTGGGAGGACCTGGTATCGAAAGCCAGTGTAGAAAAGTTGATATCATTGCAGATGCAGCATATTCCATTTTCCAAAAGCCAAAAAGTT TTACTGGCAACTTTGTCATTGATGAAAATATCTTAAAAGAAGAAGGAATAGAAAATTTTGACGTTTATGCAATTAAACCAGGTCATCCTT TGCAACCAGATTTCTTCTTAGATGAATACCCAGAAGCAGTTAGCAAGAAAGTGGAATCAACTGGTGCTGTTCCAGAATTCAAAGAAGAGA AACTGCAGCTGCAACCAAAACCACGTTCTGGAGCTGTGGAAGAAACATTTAGAATTGTTAAGGACTCTCTCAGTGATGATGTTGTTAAAG CCACTCAAGCAATCTATCTGTTTGAACTCTCCGGTGAAGATGGTGGCACGTGGTTTCTTGATCTGAAAAGCAAGGGTGGGAATGTCGGAT ATGGAGAGCCTTCTGATCAGGCAGATGTGGTGATGAGTATGACTACTGATGACTTTGTAAAAATGTTTTCAGGGAAACTAAAACCAACAA TGGCATTCATGTCAGGGAAATTGAAGATTAAAGGTAACATGGCCCTAGCAATCAAATTGGAGAAGCTAATGAATCAGATGAATGCCAGAC TGTGAAGGAAAATATAAAAAAAAAGTCGACTGCTATGCTCAAAAAGTAAAAAAAGCTCAACAGTTAAAATCTAATGTTTGTTTTCTTTCC TGTTATATTATAAGGATATGCACGTTTGTTCTGGAAAAGATAGAATTTGTCTCTAAAAGACTTGAAATTGTAATTAAAATGGCAAGCTAA TCAAACATAAGCTTCATTAAGTGGGATTCTAAGACAGTCTGTGTTTTTATATTTCAAGGGTTTAACCCTTTGAGCCTTACATCTCATTCA CTGTCTTTCTCCAAGAAAAGTATTTTGGGCGGACAGTCAGATCAAGCAGTAAAATTAGCTCTTTCAAATCTTCTTGTCATGTAAAATGAA GCTAGTCTGTTTTAAAATTTTTAGTTTTGGATTGTATACTAATGAAAATCTTAATGATGTTTTTGATTTTTATATACTTATTTTAAAGAA AATCTTATATAGTACATTTTACAAAAATTATAAAAAATGAATTAGTACTGGCGAGGACTAAATGAAACAATAATTTTTCATTTTGATAAC TAGCTTTCCAGGTGGACTTAGCCATAGGAAAATATTACTAATGTAATTTAACAAATTGCTGCATGTATTCCATTTAAAAATATGTTTAAA TTGTCCTAAAACAAAATAATTTTCTCCCTAGGAGTATGCATTTGGCTACAGTGTTTTGAAACAGAAACCTTAGAATAGGTCATTGGTATG GGCTGAACTGTGTATCCCCCAATTCATTTGTTGAGGTCCTAACTCCCATTTCTTTTGAATGTGACTGTTCGGAGATGAGGCCTTTAAAGA GGTGACTTAAGTTCAAAGGAGGCTGTTAGTCTAATCCAACATGGTGTCCTTTGGACATAAGAGATACCAGCAATGTGTGCACAGAACAAA GACCAGGAGAGGACACAGTGAGAAGGCAGTTATCTGCAAGCAAAGAGAGAGGCTTCAGAAGAAACAAAATCACCAGCACCTTGATCTTTG ACTTCTAATCTCCAGAATAGTGAGAAATAAATTTCTGTTGTTAAGCCGTCCACTGTGGGAGGCCGACGCAGGAGGATTGCTTGAGGCCAG GAGTTCAAGGCCAGCCTGGACAACATAGTAAGACCCTATCTCTACCCCCCTAATAAATTAATTTAAAAAGCCCCCCAATCTGTGGTATTT TATTATGGCAGCCCTAGCAAGCTAATACAGTGGTTTGAGAGGCTGGGAGGGTTGAGGGGAAGATAAACTTTTAAAAAGCTCTTATCTTTC ATTTCAATCAGTTAAAAATACTTGCTCAGTGTAACAATTTTGCTTCTCAGCTTCCACTCTAATATTGTTGTGCCATTAAGCAATTTAGCT AATCCTGACATTTCTTAGATTCATAATGTTAGGAGCATTTAATCTGTATTTTACAAGTTAGGAAGCAGAGGATCAGAGATGGGAAAGGAC TAGCCCAAGGCCAACATTAACAAGCCCTCTAACAAAAACTTTACAATACATTTATGTTGAATGGAACTCCAAGATCTCACCTCTCCATCC AGGAATGGAGTCCATGTAATCAAAGTGAACTTAAAAATAGGACAGTTTCAACAAGTCAGGAGATTCACAGCAACTGATCAAAGGGAGTCC AGTCAACGTGAGCAAGCGTGATTATGATGAGGAAGCCCCCTCTGCTTTAATCCACACAAGGAACGTAACCTGAAGTAACCTGATGTTAAC CAATCTGCTGTGTCTACTATGCTGTTTCCTTGTTCCTGCTAGTGCTGCTTTACAAATGCAGACCATTCTATCATACCTGGCGGGGCTTCT >In-frame_ENST00000338316_ENST00000398805_TCGA-DX-A1KZ-01A_ADCY2_chr5_7773214_+_HSDL2_chr9_115179121_length(amino acids)=1081AA_start in transcript=89_stop in transcript=3334 MWQEAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFALGLEVEDHVAFLITVPTALAIFF AIFILVCIESVFKKLLRLFSLVIWICLVAMGYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSAT PGGKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAG QMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVK MGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRD PYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTL RTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTSVLGI SFGAAFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFS ASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLGDYSQVLFERSKACIPYLKKSKVAH ILNISPPLNLNPVWFKQHCAYTIAKYGMSMYVLGMAEEFKGEIAVNALWPKTAIHTAAMDMLGGPGIESQCRKVDIIADAAYSIFQKPKS FTGNFVIDENILKEEGIENFDVYAIKPGHPLQPDFFLDEYPEAVSKKVESTGAVPEFKEEKLQLQPKPRSGAVEETFRIVKDSLSDDVVK ATQAIYLFELSGEDGGTWFLDLKSKGGNVGYGEPSDQADVVMSMTTDDFVKMFSGKLKPTMAFMSGKLKIKGNMALAIKLEKLMNQMNAR -------------------------------------------------------------- >In-frame_ENST00000537121_ENST00000398805_TCGA-DX-A1KZ-01A_ADCY2_chr5_7773214_+_HSDL2_chr9_115179121_length(transcript)=4638nt_BP=1910nt GAGGAGTTTGGTAGAAATCCCAGAAGAGCTGTTGAGAAGACCAGTGGAGCCACACGTCTAGAGGTCATGGACCTGCGCTGGGCCAGAGAT CTGCATTTGAGAGAAGCCAGCAGATCAGTAGCATTTACCACCCTGAGGCTGGGCGCAGTCACCACGGGACTCCTGACATTCAGAGAGCCA GGAGATAAAGAGAAGTCAGGAAAGGGCCTTGGGAAGAGATGGCGCATCCAGCGAGAGGAAAGCCAGGAGCGGCTTCTGCTCTCCCTGCTG CCGGCCCACATCGCCATGGAGATGAAAGCGGAGATCATCCAGAGGCTGCAGGGCCCCAAGGCGGGCCAGATGGAGAACACAAATAACTTC CACAACCTGTATGTGAAGCGGCATACAAACGTGAGCATCTTATACGCTGACATCGTTGGCTTTACCCGGCTGGCAAGTGACTGCTCCCCG GGAGAACTAGTCCACATGCTGAATGAGCTCTTTGGAAAGTTTGATCAAATTGCAAAGGAGAATGAATGCATGAGAATTAAAATTTTAGGA GACTGCTACTACTGTGTATCTGGACTCCCTATATCTCTCCCTAACCATGCCAAGAACTGTGTGAAAATGGGGCTGGACATGTGTGAAGCC ATAAAGAAAGTGAGGGATGCTACTGGAGTTGATATCAACATGCGCGTGGGCGTGCATTCTGGGAATGTCCTGTGTGGCGTGATTGGTCTG CAGAAGTGGCAATATGATGTGTGGTCACATGATGTGACCTTGGCCAACCACATGGAAGCTGGAGGGGTCCCTGGACGTGTTCACATTTCT TCTGTCACCCTGGAGCACTTGAATGGCGCTTATAAAGTGGAGGAGGGAGATGGTGACATTAGGGACCCATATTTAAAACAGCACCTGGTG AAAACCTACTTTGTGATCAACCCCAAGGGAGAACGACGGAGCCCCCAGCATCTCTTCAGACCTCGCCACACCCTTGATGGAGCCAAAATG AGGGCCTCGGTCCGCATGACCCGGTACTTGGAGTCCTGGGGGGCAGCCAAGCCCTTTGCACACCTACATCACAGGGACAGCATGACCACA GAGAACGGCAAGATCAGCACCACGGATGTACCCATGGGTCAGCATAATTTTCAAAATCGCACCTTAAGAACCAAGTCACAAAAGAAGAGA TTTGAAGAAGAATTGAATGAAAGGATGATTCAAGCAATTGATGGGATTAATGCACAGAAGCAATGGCTCAAGTCTGAAGACATTCAGAGA ATCTCACTGCTTTTCTATAACAAAGTACTAGAAAAAGAGTACCGGGCCACGGCACTGCCAGCGTTCAAGTATTATGTGACTTGTGCCTGT CTCATATTCTTCTGCATCTTCATTGTGCAGATTCTCGTGCTGCCAAAAACGTCCGTCCTGGGCATCTCCTTTGGGGCTGCGTTTCTCTTG CTGGCCTTCATCCTCTTCGTCTGCTTTGCTGGACAGCTTCTGCAATGCAGCAAAAAAGCCTCTCCCCTGCTCATGTGGCTTTTGAAGTCC TCGGGCATCATTGCCAACCGCCCCTGGCCACGGATCTCTCTCACGATCATCACCACAGCCATCATATTAATGATGGCCGTGTTCAACATG TTTTTCCTGAGTGACTCAGAGGAAACAATCCCTCCAACTGCCAACACAACAAACACAAGCTTTTCAGCCTCAAATAATCAGGTGGCGATT CTGCGTGCGCAGAATTTATTTTTCCTCCCGTACTTTATCTACAGCTGCATTCTGGGACTGATATCCTGTTCCGTGTTCCTGCGGGTAAAC TATGAGCTGAAGATGTTGATCATGATGGTGGCCTTGGTGGGCTACAACACCATCCTACTCCACACCCACGCCCACGTCCTGGGCGACTAC AGCCAGGTCTTATTTGAGAGATCTAAAGCATGTATTCCTTATTTGAAAAAGAGCAAAGTTGCTCATATCCTCAATATCAGTCCACCACTG AACCTAAATCCAGTTTGGTTCAAACAGCACTGTGCTTATACCATTGCTAAGTATGGTATGTCTATGTATGTGCTTGGAATGGCAGAAGAA TTTAAAGGTGAAATTGCAGTCAATGCATTATGGCCTAAAACAGCCATACACACTGCTGCTATGGATATGCTGGGAGGACCTGGTATCGAA AGCCAGTGTAGAAAAGTTGATATCATTGCAGATGCAGCATATTCCATTTTCCAAAAGCCAAAAAGTTTTACTGGCAACTTTGTCATTGAT GAAAATATCTTAAAAGAAGAAGGAATAGAAAATTTTGACGTTTATGCAATTAAACCAGGTCATCCTTTGCAACCAGATTTCTTCTTAGAT GAATACCCAGAAGCAGTTAGCAAGAAAGTGGAATCAACTGGTGCTGTTCCAGAATTCAAAGAAGAGAAACTGCAGCTGCAACCAAAACCA CGTTCTGGAGCTGTGGAAGAAACATTTAGAATTGTTAAGGACTCTCTCAGTGATGATGTTGTTAAAGCCACTCAAGCAATCTATCTGTTT GAACTCTCCGGTGAAGATGGTGGCACGTGGTTTCTTGATCTGAAAAGCAAGGGTGGGAATGTCGGATATGGAGAGCCTTCTGATCAGGCA GATGTGGTGATGAGTATGACTACTGATGACTTTGTAAAAATGTTTTCAGGGAAACTAAAACCAACAATGGCATTCATGTCAGGGAAATTG AAGATTAAAGGTAACATGGCCCTAGCAATCAAATTGGAGAAGCTAATGAATCAGATGAATGCCAGACTGTGAAGGAAAATATAAAAAAAA AGTCGACTGCTATGCTCAAAAAGTAAAAAAAGCTCAACAGTTAAAATCTAATGTTTGTTTTCTTTCCTGTTATATTATAAGGATATGCAC GTTTGTTCTGGAAAAGATAGAATTTGTCTCTAAAAGACTTGAAATTGTAATTAAAATGGCAAGCTAATCAAACATAAGCTTCATTAAGTG GGATTCTAAGACAGTCTGTGTTTTTATATTTCAAGGGTTTAACCCTTTGAGCCTTACATCTCATTCACTGTCTTTCTCCAAGAAAAGTAT TTTGGGCGGACAGTCAGATCAAGCAGTAAAATTAGCTCTTTCAAATCTTCTTGTCATGTAAAATGAAGCTAGTCTGTTTTAAAATTTTTA GTTTTGGATTGTATACTAATGAAAATCTTAATGATGTTTTTGATTTTTATATACTTATTTTAAAGAAAATCTTATATAGTACATTTTACA AAAATTATAAAAAATGAATTAGTACTGGCGAGGACTAAATGAAACAATAATTTTTCATTTTGATAACTAGCTTTCCAGGTGGACTTAGCC ATAGGAAAATATTACTAATGTAATTTAACAAATTGCTGCATGTATTCCATTTAAAAATATGTTTAAATTGTCCTAAAACAAAATAATTTT CTCCCTAGGAGTATGCATTTGGCTACAGTGTTTTGAAACAGAAACCTTAGAATAGGTCATTGGTATGGGCTGAACTGTGTATCCCCCAAT TCATTTGTTGAGGTCCTAACTCCCATTTCTTTTGAATGTGACTGTTCGGAGATGAGGCCTTTAAAGAGGTGACTTAAGTTCAAAGGAGGC TGTTAGTCTAATCCAACATGGTGTCCTTTGGACATAAGAGATACCAGCAATGTGTGCACAGAACAAAGACCAGGAGAGGACACAGTGAGA AGGCAGTTATCTGCAAGCAAAGAGAGAGGCTTCAGAAGAAACAAAATCACCAGCACCTTGATCTTTGACTTCTAATCTCCAGAATAGTGA GAAATAAATTTCTGTTGTTAAGCCGTCCACTGTGGGAGGCCGACGCAGGAGGATTGCTTGAGGCCAGGAGTTCAAGGCCAGCCTGGACAA CATAGTAAGACCCTATCTCTACCCCCCTAATAAATTAATTTAAAAAGCCCCCCAATCTGTGGTATTTTATTATGGCAGCCCTAGCAAGCT AATACAGTGGTTTGAGAGGCTGGGAGGGTTGAGGGGAAGATAAACTTTTAAAAAGCTCTTATCTTTCATTTCAATCAGTTAAAAATACTT GCTCAGTGTAACAATTTTGCTTCTCAGCTTCCACTCTAATATTGTTGTGCCATTAAGCAATTTAGCTAATCCTGACATTTCTTAGATTCA TAATGTTAGGAGCATTTAATCTGTATTTTACAAGTTAGGAAGCAGAGGATCAGAGATGGGAAAGGACTAGCCCAAGGCCAACATTAACAA GCCCTCTAACAAAAACTTTACAATACATTTATGTTGAATGGAACTCCAAGATCTCACCTCTCCATCCAGGAATGGAGTCCATGTAATCAA AGTGAACTTAAAAATAGGACAGTTTCAACAAGTCAGGAGATTCACAGCAACTGATCAAAGGGAGTCCAGTCAACGTGAGCAAGCGTGATT ATGATGAGGAAGCCCCCTCTGCTTTAATCCACACAAGGAACGTAACCTGAAGTAACCTGATGTTAACCAATCTGCTGTGTCTACTATGCT GTTTCCTTGTTCCTGCTAGTGCTGCTTTACAAATGCAGACCATTCTATCATACCTGGCGGGGCTTCTGTTTTATTTTGTAGGCTGGATGC >In-frame_ENST00000537121_ENST00000398805_TCGA-DX-A1KZ-01A_ADCY2_chr5_7773214_+_HSDL2_chr9_115179121_length(amino acids)=901AA_start in transcript=66_stop in transcript=2771 MDLRWARDLHLREASRSVAFTTLRLGAVTTGLLTFREPGDKEKSGKGLGKRWRIQREESQERLLLSLLPAHIAMEMKAEIIQRLQGPKAG QMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVK MGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRD PYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTL RTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTSVLGI SFGAAFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFS ASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLGDYSQVLFERSKACIPYLKKSKVAH ILNISPPLNLNPVWFKQHCAYTIAKYGMSMYVLGMAEEFKGEIAVNALWPKTAIHTAAMDMLGGPGIESQCRKVDIIADAAYSIFQKPKS FTGNFVIDENILKEEGIENFDVYAIKPGHPLQPDFFLDEYPEAVSKKVESTGAVPEFKEEKLQLQPKPRSGAVEETFRIVKDSLSDDVVK ATQAIYLFELSGEDGGTWFLDLKSKGGNVGYGEPSDQADVVMSMTTDDFVKMFSGKLKPTMAFMSGKLKIKGNMALAIKLEKLMNQMNAR -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for ADCY2-HSDL2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 905_922 | 794.6666666666666 | 1092.0 | GNAS |
Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 990_993 | 794.6666666666666 | 1092.0 | GNAS |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for ADCY2-HSDL2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | ADCY2 | Q08462 | DB09121 | Aurothioglucose | Small molecule | Approved|Withdrawn | |
Hgene | ADCY2 | Q08462 | DB09121 | Aurothioglucose | Small molecule | Approved|Withdrawn |
Top |
Related Diseases for ADCY2-HSDL2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ADCY2 | C0005586 | Bipolar Disorder | 2 | CTD_human;PSYGENET |
Hgene | ADCY2 | C0004096 | Asthma | 1 | CTD_human |
Hgene | ADCY2 | C0005587 | Depression, Bipolar | 1 | CTD_human |
Hgene | ADCY2 | C0024713 | Manic Disorder | 1 | CTD_human |
Hgene | ADCY2 | C0338831 | Manic | 1 | CTD_human |
Tgene | HSDL2 | C0023903 | Liver neoplasms | 1 | CTD_human |
Tgene | HSDL2 | C0345904 | Malignant neoplasm of liver | 1 | CTD_human |