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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:DNAJC9-DENND5A (FusionGDB2 ID:23561) |
Fusion Gene Summary for DNAJC9-DENND5A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DNAJC9-DENND5A | Fusion gene ID: 23561 | Hgene | Tgene | Gene symbol | DNAJC9 | DENND5A | Gene ID | 23234 | 23258 |
| Gene name | DnaJ heat shock protein family (Hsp40) member C9 | DENN domain containing 5A | |
| Synonyms | HDJC9|JDD1|SB73 | EIEE49|RAB6IP1 | |
| Cytomap | 10q22.2 | 11p15.4 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dnaJ homolog subfamily C member 9DnaJ (Hsp40) homolog, subfamily C, member 9DnaJ protein SB73 | DENN domain-containing protein 5ADENN/MADD domain containing 5ARAB6 interacting protein 1rab6-interacting protein 1 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q6IQ26 | |
| Ensembl transtripts involved in fusion gene | ENST00000453189, ENST00000372950, | ENST00000328194, ENST00000530044, ENST00000527700, ENST00000526523, | |
| Fusion gene scores | * DoF score | 8 X 7 X 5=280 | 15 X 15 X 6=1350 |
| # samples | 9 | 16 | |
| ** MAII score | log2(9/280*10)=-1.63742992061529 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(16/1350*10)=-3.07681559705083 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DNAJC9 [Title/Abstract] AND DENND5A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | DNAJC9(75003600)-DENND5A(9173989), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | DNAJC9 | GO:0032781 | positive regulation of ATPase activity | 17182002 |
| Fusion gene breakpoints across DNAJC9 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across DENND5A (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | Non-Cancer | 135N | DNAJC9 | chr10 | 75003600 | - | DENND5A | chr11 | 9173989 | - |
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Fusion Gene ORF analysis for DNAJC9-DENND5A |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000453189 | ENST00000328194 | DNAJC9 | chr10 | 75003600 | - | DENND5A | chr11 | 9173989 | - |
| intron-3CDS | ENST00000453189 | ENST00000530044 | DNAJC9 | chr10 | 75003600 | - | DENND5A | chr11 | 9173989 | - |
| intron-3CDS | ENST00000453189 | ENST00000527700 | DNAJC9 | chr10 | 75003600 | - | DENND5A | chr11 | 9173989 | - |
| intron-intron | ENST00000453189 | ENST00000526523 | DNAJC9 | chr10 | 75003600 | - | DENND5A | chr11 | 9173989 | - |
| In-frame | ENST00000372950 | ENST00000328194 | DNAJC9 | chr10 | 75003600 | - | DENND5A | chr11 | 9173989 | - |
| In-frame | ENST00000372950 | ENST00000530044 | DNAJC9 | chr10 | 75003600 | - | DENND5A | chr11 | 9173989 | - |
| In-frame | ENST00000372950 | ENST00000527700 | DNAJC9 | chr10 | 75003600 | - | DENND5A | chr11 | 9173989 | - |
| 5CDS-intron | ENST00000372950 | ENST00000526523 | DNAJC9 | chr10 | 75003600 | - | DENND5A | chr11 | 9173989 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000372950 | DNAJC9 | chr10 | 75003600 | - | ENST00000328194 | DENND5A | chr11 | 9173989 | - | 4610 | 2336 | 1616 | 3763 | 715 |
| ENST00000372950 | DNAJC9 | chr10 | 75003600 | - | ENST00000530044 | DENND5A | chr11 | 9173989 | - | 3942 | 2336 | 1616 | 3625 | 669 |
| ENST00000372950 | DNAJC9 | chr10 | 75003600 | - | ENST00000527700 | DENND5A | chr11 | 9173989 | - | 3931 | 2336 | 1616 | 3763 | 715 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000372950 | ENST00000328194 | DNAJC9 | chr10 | 75003600 | - | DENND5A | chr11 | 9173989 | - | 0.000300677 | 0.99969935 |
| ENST00000372950 | ENST00000530044 | DNAJC9 | chr10 | 75003600 | - | DENND5A | chr11 | 9173989 | - | 0.000516508 | 0.99948347 |
| ENST00000372950 | ENST00000527700 | DNAJC9 | chr10 | 75003600 | - | DENND5A | chr11 | 9173989 | - | 0.000496593 | 0.9995034 |
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Fusion Genomic Features for DNAJC9-DENND5A |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for DNAJC9-DENND5A |
| Go to FGviewer for the breakpoints of chr10:75003600-chr11:9173989 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | DENND5A |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:G3V7Q0, ECO:0000269|PubMed:20937701}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DNAJC9 | chr10:75003600 | chr11:9173989 | ENST00000372950 | - | 4 | 5 | 15_82 | 221.0 | 261.0 | Domain | J |
| Tgene | DENND5A | chr10:75003600 | chr11:9173989 | ENST00000328194 | 11 | 23 | 1134_1282 | 812.0 | 1288.0 | Domain | RUN 2 | |
| Tgene | DENND5A | chr10:75003600 | chr11:9173989 | ENST00000328194 | 11 | 23 | 954_1062 | 812.0 | 1288.0 | Domain | PLAT | |
| Tgene | DENND5A | chr10:75003600 | chr11:9173989 | ENST00000530044 | 11 | 23 | 1134_1282 | 812.0 | 1242.0 | Domain | RUN 2 | |
| Tgene | DENND5A | chr10:75003600 | chr11:9173989 | ENST00000530044 | 11 | 23 | 954_1062 | 812.0 | 1242.0 | Domain | PLAT |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | DENND5A | chr10:75003600 | chr11:9173989 | ENST00000328194 | 11 | 23 | 3_9 | 812.0 | 1288.0 | Compositional bias | Note=Poly-Gly | |
| Tgene | DENND5A | chr10:75003600 | chr11:9173989 | ENST00000328194 | 11 | 23 | 593_598 | 812.0 | 1288.0 | Compositional bias | Note=Poly-Asp | |
| Tgene | DENND5A | chr10:75003600 | chr11:9173989 | ENST00000530044 | 11 | 23 | 3_9 | 812.0 | 1242.0 | Compositional bias | Note=Poly-Gly | |
| Tgene | DENND5A | chr10:75003600 | chr11:9173989 | ENST00000530044 | 11 | 23 | 593_598 | 812.0 | 1242.0 | Compositional bias | Note=Poly-Asp | |
| Tgene | DENND5A | chr10:75003600 | chr11:9173989 | ENST00000328194 | 11 | 23 | 278_414 | 812.0 | 1288.0 | Domain | cDENN | |
| Tgene | DENND5A | chr10:75003600 | chr11:9173989 | ENST00000328194 | 11 | 23 | 416_598 | 812.0 | 1288.0 | Domain | dDENN | |
| Tgene | DENND5A | chr10:75003600 | chr11:9173989 | ENST00000328194 | 11 | 23 | 57_259 | 812.0 | 1288.0 | Domain | uDENN | |
| Tgene | DENND5A | chr10:75003600 | chr11:9173989 | ENST00000328194 | 11 | 23 | 787_950 | 812.0 | 1288.0 | Domain | RUN 1 | |
| Tgene | DENND5A | chr10:75003600 | chr11:9173989 | ENST00000530044 | 11 | 23 | 278_414 | 812.0 | 1242.0 | Domain | cDENN | |
| Tgene | DENND5A | chr10:75003600 | chr11:9173989 | ENST00000530044 | 11 | 23 | 416_598 | 812.0 | 1242.0 | Domain | dDENN | |
| Tgene | DENND5A | chr10:75003600 | chr11:9173989 | ENST00000530044 | 11 | 23 | 57_259 | 812.0 | 1242.0 | Domain | uDENN | |
| Tgene | DENND5A | chr10:75003600 | chr11:9173989 | ENST00000530044 | 11 | 23 | 787_950 | 812.0 | 1242.0 | Domain | RUN 1 |
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Fusion Gene Sequence for DNAJC9-DENND5A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000372950_ENST00000328194_135N_DNAJC9_chr10_75003600_-_DENND5A_chr11_9173989_length(transcript)=4610nt_BP=2336nt ATTTCAGTGTGCGATTTCAATTTTCCGTAGCAAATGTATATATAGAAAAATGTTAAAATAGATGTATTTGAATACCTTAAAAAATACAAG AAACTGGAAGAAAGATAATATTGCAAAGCATCTACATATATCCTAGGCCTTTTGTGTACAAGGTTATTTGTGACAATTGTAAGGTATTAT GAAGGCAGGTAGGATTATCTCCGTTTTACAGATAGGGAAGCTGAGGCCTAGAGGTGGAAACTTGCCCAGTGATGTAAGATTCATCTCCCG GTTATGCCCTCCTGGAAAGCCCTTCCCAACATATTATGTTGTCCATAGAGGGAAAAATGAGCAAAGACAGATGGCTTAACTCTGGTGTGT GACTAAGATATAGGAAATTTATAGAGGAGGTTCTATCAATGTGCCGACTTACTTTGTGTTTTATGTTCTGAGAACGATTACCAGCCATCT CAAATTCTGTGGTTGTCAAAGCTCCCCTGGGGTTGTTGCTGGTTGGCCCCCACTTGCTTTGAGACTTTGATGCCAGGGCAGGTTGAGAGG AACTGACTTCAGCTGAGTTTGATCTTGGATCTGGGAAAGAGAAATGCTTTGAAAATCACGGCAACTCTGGGAAGTTTAAAAGATATTAAT GTATCCTGGAGAGTTTGAGGCTTTGCAGAAACTTATTGGCAGAGCAGAATGATTCTGAAAAATGCTACATCAGTGAGGGGATATTTGATA AGGTATTTTCTGCCAACTCGGGTATTCACTTAGCATTGTTTATCCTTTAAGATATGTATACACATACTTCCTCTGTGAGTTTACCCTACT AACAAAGTTTTATCCCCAGCCTCAACCTTGCTTTGGGTCTCCAGGCCCAAGTTTCTCACCATCTCTTGGATGATTGCTCCAGCCCACTCT GCTGCCACCTGGGATCCAACATGTTCAAACCCAGCTGTGAACTTCACAGAGTATTAAAAGAAAGAGCCTTTGCTTCAGCAGTTTATGTTA TTAAGACGGAGGCTTGGGTCATGTTATCTCTCTCCACCAATGTGTAAGGTGAAAGTCCTATTAGGTAAGAGTTTTTGGAAGACCCGTGTT TTGTGCTTTTTGGGTTTCAGTATAGGGTTTTTTCCTACAGGGCTAGAGGGAAAGTACCCCAGCATTTCCAACCAGTGGGGTGCAAAATTA TTTGGGTCTACAGCTTTACCTATTCCTTTCAAGAACATTTTTGAAAAAACACATCTGTTAAGTTGAACCATGTGTAACTGCTGAATGCTG ATGTTTGGCCGTTTTCTACTTAAAAAAATAGGCCAGCAGTTTGTAAATTCAAGCTAATATATGAACTTTTTGAAAAAGTTGTTCTTGGAC ACTAAAAGGTAAGACGGACGCCAGATTTCCAGAGCAAGGGGAGGAGAGACCCGAGCAACATCACTTCCCTGAAGACCTAGCTCCTGCGCG CGGCCGGGGACTGTGACTCCACATGCCGGCGTTACTTACCCGGGCCCGCGCCTGACTCGCCACACCTCATTTTGCGGCCGCCGTAAAGCG CGGATGCGCGGCGTGGCCACGCCCCTTCAGTGCTTGTGACGCAGGCGCCCTGGGCTTTTTGGGCGCGAAAAAGAAGCAGTCCTGGGTTGT ACCCGGCGCAGCTGGGAGCGGCTGCTTCCTCCGGGGTCGTATCTCCGCCCGGCATGGGGCTGCTGGACCTTTGCGAGGAAGTGTTCGGCA CCGCCGACCTTTACCGGGTGCTGGGCGTGCGACGCGAGGCCTCCGACGGCGAGGTCCGACGAGGCTACCACAAGGTGTCCCTGCAGGTAC ACCCGGACCGGGTGGGTGAGGGCGACAAGGAGGACGCCACCCGCCGCTTCCAGATCCTGGGAAAAGTCTATTCCGTTCTCAGTGACAGAG AACAGAGAGCAGTGTACGATGAGCAGGGAACAGTGGACGAGGACTCTCCTGTGCTCACCCAAGACCGAGACTGGGAGGCGTATTGGCGGC TACTCTTTAAAAAGATATCTTTAGAGGACATTCAAGCTTTTGAAAAGACATACAAAGGTTCGGAAGAAGAGCTGGCTGATATTAAGCAGG CCTATCTGGACTTCAAGGGTGACATGGATCAGATCATGGAGTCTGTGCTTTGCGTGCAGTACACAGAGGAACCCAGGATAAGGAATATCA TTCAGCAAGCTATTGACGCCGGAGAGGTCCCATCCTATAATGCCTTTGTCAAAGAATCGAAACAAAAGATGAATGCAAGGAAAAGGAGGG CTCAGGAAGAGGCCAAAGAAGCAGAAATGAGCAGAAAGGAGTTGGGGCTTGATGAAGGCGTGGATAGCCTGAAGGCAGCCATTCAGGGGA AATCAGCCTTATGGTCCCACCTGTTACATTATCAGGACAACCGGCAGAGAAAACTCACATCAGGAAGCCTCAGTACCTCAGGAATACTTC TTGATTCAGAACGTAGGAAGTCTGATGCCAGCTCACTCATGCCTCCCCTGAGGATCTCCCTGATTCAGGATATGAGGCACATCCAGAACA TCGGGGAAATCAAGACTGATGTGGGAAAGGCCAGAGCATGGGTGCGACTGTCCATGGAAAAAAAGTTACTTTCCAGACACCTGAAGCAGC TCCTCTCAGACCATGAGCTCACCAAAAAGTTATATAAGCGCTATGCCTTCCTGCGCTGTGATGACGAGAAGGAGCAGTTCCTCTATCACC TCCTGTCTTTCAATGCCGTCGATTACTTTTGCTTCACCAATGTCTTCACAACTATCCTGATCCCGTACCACATTCTGATCGTACCAAGCA AGAAGCTGGGGGGCTCCATGTTCACTGCCAACCCATGGATCTGTATATCAGGAGAATTGGGTGAGACACAGATCATGCAGATTCCCAGGA ATGTGCTAGAGATGACCTTCGAGTGCCAGAACTTGGGGAAGCTTACTACTGTCCAGATTGGCCATGATAACTCTGGGCTGTATGCCAAAT GGCTGGTGGAGTATGTGATGGTCAGGAATGAGATCACAGGACATACCTACAAGTTCCCGTGTGGCCGGTGGTTAGGGAAGGGCATGGATG ATGGAAGCCTGGAGCGGATCCTAGTTGGGGAGCTGCTCACATCCCAGCCTGAGGTGGATGAGAGGCCATGCCGGACCCCGCCGCTGCAGC AGTCCCCCAGTGTCATCCGGAGGCTTGTTACCATCTCACCCAACAACAAGCCCAAGCTGAACACTGGGCAGATCCAGGAGTCCATCGGGG AGGCAGTCAATGGCATTGTGAAGCACTTCCATAAGCCTGAGAAAGAGCGAGGCAGTCTGACGCTGTTGCTCTGTGGAGAGTGTGGCCTTG TCTCGGCCTTGGAACAGGCTTTCCAGCATGGATTTAAATCGCCCCGGCTCTTCAAAAATGTCTTCATTTGGGATTTCCTGGAAAAAGCAC AAACCTATTATGAGACATTAGAGAAGAATGAAGTAGTCCCTGAGGAAAACTGGCATACAAGAGCCCGGAACTTCTGCCGATTTGTCACTG CAATCAACAATACTCCCCGGAACATCGGCAAGGATGGCAAGTTTCAGATGCTGGTGTGCTTGGGAGCCAGAGATCACCTCCTACACCACT GGATTGCCCTGCTGGCTGACTGCCCCATCACTGCACACATGTATGAGGATGTGGCACTGATCAAAGACCATACACTTGTCAATTCCTTGA TTCGTGTGCTGCAGACATTGCAGGAGTTCAACATCACGCTGGAGACGTCCCTTGTCAAGGGCATCGACATCTGACCTCCCAGCACCAGCC AGCAGCAGGACTGAGAAAGACTCACCCTGCAGCTCTGACCTTTTTTCCCAAAGGGACTTAAGCGATTGTGCAGGAGTAGGAGACAAAATG TACACTCACTGTAAAAAGAAAACTAGAGGATTTTTGGAATAAATAATCTATTTTAGAGTTTATTTGCTGATTTGCTTTTTACACACTTTC ATGTGAAAGAGTGATAGGGAGAGGGAGCGAGGCTGGTGCCGCTTATTTTGAAGCTGGTGCCCTCCCTCGCCGTGGCCACATGCTGGAAGC CTGAGGCCTCCCTGGACTGAGCCTGTGGCACTGCGTGCGGGACAGTTATGTTTCCTTGCCCCGTCGCATTAATGAGGCCCTTCCACATCA TTTTTAAACTAATGTTTTTCTATATTAACATTATTATGGATATTTGGCTTTCATAGGCCACACACAGGTGTGCTGCGCGGGAAGCCCCAT GCTCCAATCAAAGGGATTTTTAGTAGTGCCTCTAAGCAAGCACCGATGAGTCAGTCCCACGTATTTTCTTTTTTGTCAGTATTGTTTGGG AAGGAGACATGCCGGGATGTGTCATCGTGCCAAATACCACATTTCCTGTTGGCACAGTTTCACAGAAGTAAACATAAGCATGTTTTAACA GGTTTTTCTTTTCTTTTTTCTTTTTTAAAATGTTTTATTTATTTAACCCGCCATTGTGTGTTTTTAAGTATTTTCTTTTTTTAAGGAAAG GAAAAGCTTGTCACAATCTAACTGGCTATGTTATTATTATTAAATTTATGTTTTGCAACTTAGAAACCAGCTACAGTATGGCCCACTTAA >In-frame_ENST00000372950_ENST00000328194_135N_DNAJC9_chr10_75003600_-_DENND5A_chr11_9173989_length(amino acids)=715AA_start in transcript=1616_stop in transcript=3763 MYPAQLGAAASSGVVSPPGMGLLDLCEEVFGTADLYRVLGVRREASDGEVRRGYHKVSLQVHPDRVGEGDKEDATRRFQILGKVYSVLSD REQRAVYDEQGTVDEDSPVLTQDRDWEAYWRLLFKKISLEDIQAFEKTYKGSEEELADIKQAYLDFKGDMDQIMESVLCVQYTEEPRIRN IIQQAIDAGEVPSYNAFVKESKQKMNARKRRAQEEAKEAEMSRKELGLDEGVDSLKAAIQGKSALWSHLLHYQDNRQRKLTSGSLSTSGI LLDSERRKSDASSLMPPLRISLIQDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLY HLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTANPWICISGELGETQIMQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYA KWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERILVGELLTSQPEVDERPCRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQESI GEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHGFKSPRLFKNVFIWDFLEKAQTYYETLEKNEVVPEENWHTRARNFCRFV -------------------------------------------------------------- >In-frame_ENST00000372950_ENST00000530044_135N_DNAJC9_chr10_75003600_-_DENND5A_chr11_9173989_length(transcript)=3942nt_BP=2336nt ATTTCAGTGTGCGATTTCAATTTTCCGTAGCAAATGTATATATAGAAAAATGTTAAAATAGATGTATTTGAATACCTTAAAAAATACAAG AAACTGGAAGAAAGATAATATTGCAAAGCATCTACATATATCCTAGGCCTTTTGTGTACAAGGTTATTTGTGACAATTGTAAGGTATTAT GAAGGCAGGTAGGATTATCTCCGTTTTACAGATAGGGAAGCTGAGGCCTAGAGGTGGAAACTTGCCCAGTGATGTAAGATTCATCTCCCG GTTATGCCCTCCTGGAAAGCCCTTCCCAACATATTATGTTGTCCATAGAGGGAAAAATGAGCAAAGACAGATGGCTTAACTCTGGTGTGT GACTAAGATATAGGAAATTTATAGAGGAGGTTCTATCAATGTGCCGACTTACTTTGTGTTTTATGTTCTGAGAACGATTACCAGCCATCT CAAATTCTGTGGTTGTCAAAGCTCCCCTGGGGTTGTTGCTGGTTGGCCCCCACTTGCTTTGAGACTTTGATGCCAGGGCAGGTTGAGAGG AACTGACTTCAGCTGAGTTTGATCTTGGATCTGGGAAAGAGAAATGCTTTGAAAATCACGGCAACTCTGGGAAGTTTAAAAGATATTAAT GTATCCTGGAGAGTTTGAGGCTTTGCAGAAACTTATTGGCAGAGCAGAATGATTCTGAAAAATGCTACATCAGTGAGGGGATATTTGATA AGGTATTTTCTGCCAACTCGGGTATTCACTTAGCATTGTTTATCCTTTAAGATATGTATACACATACTTCCTCTGTGAGTTTACCCTACT AACAAAGTTTTATCCCCAGCCTCAACCTTGCTTTGGGTCTCCAGGCCCAAGTTTCTCACCATCTCTTGGATGATTGCTCCAGCCCACTCT GCTGCCACCTGGGATCCAACATGTTCAAACCCAGCTGTGAACTTCACAGAGTATTAAAAGAAAGAGCCTTTGCTTCAGCAGTTTATGTTA TTAAGACGGAGGCTTGGGTCATGTTATCTCTCTCCACCAATGTGTAAGGTGAAAGTCCTATTAGGTAAGAGTTTTTGGAAGACCCGTGTT TTGTGCTTTTTGGGTTTCAGTATAGGGTTTTTTCCTACAGGGCTAGAGGGAAAGTACCCCAGCATTTCCAACCAGTGGGGTGCAAAATTA TTTGGGTCTACAGCTTTACCTATTCCTTTCAAGAACATTTTTGAAAAAACACATCTGTTAAGTTGAACCATGTGTAACTGCTGAATGCTG ATGTTTGGCCGTTTTCTACTTAAAAAAATAGGCCAGCAGTTTGTAAATTCAAGCTAATATATGAACTTTTTGAAAAAGTTGTTCTTGGAC ACTAAAAGGTAAGACGGACGCCAGATTTCCAGAGCAAGGGGAGGAGAGACCCGAGCAACATCACTTCCCTGAAGACCTAGCTCCTGCGCG CGGCCGGGGACTGTGACTCCACATGCCGGCGTTACTTACCCGGGCCCGCGCCTGACTCGCCACACCTCATTTTGCGGCCGCCGTAAAGCG CGGATGCGCGGCGTGGCCACGCCCCTTCAGTGCTTGTGACGCAGGCGCCCTGGGCTTTTTGGGCGCGAAAAAGAAGCAGTCCTGGGTTGT ACCCGGCGCAGCTGGGAGCGGCTGCTTCCTCCGGGGTCGTATCTCCGCCCGGCATGGGGCTGCTGGACCTTTGCGAGGAAGTGTTCGGCA CCGCCGACCTTTACCGGGTGCTGGGCGTGCGACGCGAGGCCTCCGACGGCGAGGTCCGACGAGGCTACCACAAGGTGTCCCTGCAGGTAC ACCCGGACCGGGTGGGTGAGGGCGACAAGGAGGACGCCACCCGCCGCTTCCAGATCCTGGGAAAAGTCTATTCCGTTCTCAGTGACAGAG AACAGAGAGCAGTGTACGATGAGCAGGGAACAGTGGACGAGGACTCTCCTGTGCTCACCCAAGACCGAGACTGGGAGGCGTATTGGCGGC TACTCTTTAAAAAGATATCTTTAGAGGACATTCAAGCTTTTGAAAAGACATACAAAGGTTCGGAAGAAGAGCTGGCTGATATTAAGCAGG CCTATCTGGACTTCAAGGGTGACATGGATCAGATCATGGAGTCTGTGCTTTGCGTGCAGTACACAGAGGAACCCAGGATAAGGAATATCA TTCAGCAAGCTATTGACGCCGGAGAGGTCCCATCCTATAATGCCTTTGTCAAAGAATCGAAACAAAAGATGAATGCAAGGAAAAGGAGGG CTCAGGAAGAGGCCAAAGAAGCAGAAATGAGCAGAAAGGAGTTGGGGCTTGATGAAGGCGTGGATAGCCTGAAGGCAGCCATTCAGGGGA AATCAGCCTTATGGTCCCACCTGTTACATTATCAGGACAACCGGCAGAGAAAACTCACATCAGGAAGCCTCAGTACCTCAGGAATACTTC TTGATTCAGAACGTAGGAAGTCTGATGCCAGCTCACTCATGCCTCCCCTGAGGATCTCCCTGATTCAGGATATGAGGCACATCCAGAACA TCGGGGAAATCAAGACTGATGTGGGAAAGGCCAGAGCATGGGTGCGACTGTCCATGGAAAAAAAGTTACTTTCCAGACACCTGAAGCAGC TCCTCTCAGACCATGAGCTCACCAAAAAGTTATATAAGCGCTATGCCTTCCTGCGCTGTGATGACGAGAAGGAGCAGTTCCTCTATCACC TCCTGTCTTTCAATGCCGTCGATTACTTTTGCTTCACCAATGTCTTCACAACTATCCTGATCCCGTACCACATTCTGATCGTACCAAGCA AGAAGCTGGGGGGCTCCATGTTCACTGCCAACCCATGGATCTGTATATCAGGAGAATTGGGTGAGACACAGATCATGCAGATTCCCAGGA ATGTGCTAGAGATGACCTTCGAGTGCCAGAACTTGGGGAAGCTTACTACTGTCCAGATTGGCCATGATAACTCTGGGCTGTATGCCAAAT GGCTGGTGGAGTATGTGATGGTCAGGAATGAGATCACAGGACATACCTACAAGTTCCCGTGTGGCCGGTGGTTAGGGAAGGGCATGGATG ATGGAAGCCTGGAGCGGATCCTAGTTGGGGAGCTGCTCACATCCCAGCCTGAGGTGGATGAGAGGCCATGCCGGACCCCGCCGCTGCAGC AGTCCCCCAGTGTCATCCGGAGGCTTGTTACCATCTCACCCAACAACAAGCCCAAGCTGAACACTGGGCAGATCCAGGAGTCCATCGGGG AGGCAGTCAATGGCATTGTGAAGCACTTCCATAAGCCTGAGAAAGAGCGAGGCAGTCTGACGCTGTTGCTCTGTGGAGAGTGTGGCCTTG TCTCGGCCTTGGAACAGGCTTTCCAGCATGGATTTAAATCGCCCCGGCTCTTCAAAAATGTCTTCATTTGGGATTTCCTGGAAAAAGCAC AAACCTATTATGAGACATTAGAGAAGAATGAAGTAGTCCCTGAGGAAAACTGGCATACAAGAGCCCGGAACTTCTGCCGATTTGTCACTG CAATCAACAATACTCCCCGGAACATCGGCAAGGATGAGATCACCTCCTACACCACTGGATTGCCCTGCTGGCTGACTGCCCCATCACTGC ACACATGTATGAGGATGTGGCACTGATCAAAGACCATACACTTGTCAATTCCTTGATTCGTGTGCTGCAGACATTGCAGGAGTTCAACAT CACGCTGGAGACGTCCCTTGTCAAGGGCATCGACATCTGACCTCCCAGCACCAGCCAGCAGCAGGACTGAGAAAGACTCACCCTGCAGCT CTGACCTTTTTTCCCAAAGGGACTTAAGCGATTGTGCAGGAGTAGGAGACAAAATGTACACTCACTGTAAAAAGAAAACTAGAGGATTTT >In-frame_ENST00000372950_ENST00000530044_135N_DNAJC9_chr10_75003600_-_DENND5A_chr11_9173989_length(amino acids)=669AA_start in transcript=1616_stop in transcript=3625 MYPAQLGAAASSGVVSPPGMGLLDLCEEVFGTADLYRVLGVRREASDGEVRRGYHKVSLQVHPDRVGEGDKEDATRRFQILGKVYSVLSD REQRAVYDEQGTVDEDSPVLTQDRDWEAYWRLLFKKISLEDIQAFEKTYKGSEEELADIKQAYLDFKGDMDQIMESVLCVQYTEEPRIRN IIQQAIDAGEVPSYNAFVKESKQKMNARKRRAQEEAKEAEMSRKELGLDEGVDSLKAAIQGKSALWSHLLHYQDNRQRKLTSGSLSTSGI LLDSERRKSDASSLMPPLRISLIQDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLY HLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTANPWICISGELGETQIMQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYA KWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERILVGELLTSQPEVDERPCRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQESI GEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHGFKSPRLFKNVFIWDFLEKAQTYYETLEKNEVVPEENWHTRARNFCRFV -------------------------------------------------------------- >In-frame_ENST00000372950_ENST00000527700_135N_DNAJC9_chr10_75003600_-_DENND5A_chr11_9173989_length(transcript)=3931nt_BP=2336nt ATTTCAGTGTGCGATTTCAATTTTCCGTAGCAAATGTATATATAGAAAAATGTTAAAATAGATGTATTTGAATACCTTAAAAAATACAAG AAACTGGAAGAAAGATAATATTGCAAAGCATCTACATATATCCTAGGCCTTTTGTGTACAAGGTTATTTGTGACAATTGTAAGGTATTAT GAAGGCAGGTAGGATTATCTCCGTTTTACAGATAGGGAAGCTGAGGCCTAGAGGTGGAAACTTGCCCAGTGATGTAAGATTCATCTCCCG GTTATGCCCTCCTGGAAAGCCCTTCCCAACATATTATGTTGTCCATAGAGGGAAAAATGAGCAAAGACAGATGGCTTAACTCTGGTGTGT GACTAAGATATAGGAAATTTATAGAGGAGGTTCTATCAATGTGCCGACTTACTTTGTGTTTTATGTTCTGAGAACGATTACCAGCCATCT CAAATTCTGTGGTTGTCAAAGCTCCCCTGGGGTTGTTGCTGGTTGGCCCCCACTTGCTTTGAGACTTTGATGCCAGGGCAGGTTGAGAGG AACTGACTTCAGCTGAGTTTGATCTTGGATCTGGGAAAGAGAAATGCTTTGAAAATCACGGCAACTCTGGGAAGTTTAAAAGATATTAAT GTATCCTGGAGAGTTTGAGGCTTTGCAGAAACTTATTGGCAGAGCAGAATGATTCTGAAAAATGCTACATCAGTGAGGGGATATTTGATA AGGTATTTTCTGCCAACTCGGGTATTCACTTAGCATTGTTTATCCTTTAAGATATGTATACACATACTTCCTCTGTGAGTTTACCCTACT AACAAAGTTTTATCCCCAGCCTCAACCTTGCTTTGGGTCTCCAGGCCCAAGTTTCTCACCATCTCTTGGATGATTGCTCCAGCCCACTCT GCTGCCACCTGGGATCCAACATGTTCAAACCCAGCTGTGAACTTCACAGAGTATTAAAAGAAAGAGCCTTTGCTTCAGCAGTTTATGTTA TTAAGACGGAGGCTTGGGTCATGTTATCTCTCTCCACCAATGTGTAAGGTGAAAGTCCTATTAGGTAAGAGTTTTTGGAAGACCCGTGTT TTGTGCTTTTTGGGTTTCAGTATAGGGTTTTTTCCTACAGGGCTAGAGGGAAAGTACCCCAGCATTTCCAACCAGTGGGGTGCAAAATTA TTTGGGTCTACAGCTTTACCTATTCCTTTCAAGAACATTTTTGAAAAAACACATCTGTTAAGTTGAACCATGTGTAACTGCTGAATGCTG ATGTTTGGCCGTTTTCTACTTAAAAAAATAGGCCAGCAGTTTGTAAATTCAAGCTAATATATGAACTTTTTGAAAAAGTTGTTCTTGGAC ACTAAAAGGTAAGACGGACGCCAGATTTCCAGAGCAAGGGGAGGAGAGACCCGAGCAACATCACTTCCCTGAAGACCTAGCTCCTGCGCG CGGCCGGGGACTGTGACTCCACATGCCGGCGTTACTTACCCGGGCCCGCGCCTGACTCGCCACACCTCATTTTGCGGCCGCCGTAAAGCG CGGATGCGCGGCGTGGCCACGCCCCTTCAGTGCTTGTGACGCAGGCGCCCTGGGCTTTTTGGGCGCGAAAAAGAAGCAGTCCTGGGTTGT ACCCGGCGCAGCTGGGAGCGGCTGCTTCCTCCGGGGTCGTATCTCCGCCCGGCATGGGGCTGCTGGACCTTTGCGAGGAAGTGTTCGGCA CCGCCGACCTTTACCGGGTGCTGGGCGTGCGACGCGAGGCCTCCGACGGCGAGGTCCGACGAGGCTACCACAAGGTGTCCCTGCAGGTAC ACCCGGACCGGGTGGGTGAGGGCGACAAGGAGGACGCCACCCGCCGCTTCCAGATCCTGGGAAAAGTCTATTCCGTTCTCAGTGACAGAG AACAGAGAGCAGTGTACGATGAGCAGGGAACAGTGGACGAGGACTCTCCTGTGCTCACCCAAGACCGAGACTGGGAGGCGTATTGGCGGC TACTCTTTAAAAAGATATCTTTAGAGGACATTCAAGCTTTTGAAAAGACATACAAAGGTTCGGAAGAAGAGCTGGCTGATATTAAGCAGG CCTATCTGGACTTCAAGGGTGACATGGATCAGATCATGGAGTCTGTGCTTTGCGTGCAGTACACAGAGGAACCCAGGATAAGGAATATCA TTCAGCAAGCTATTGACGCCGGAGAGGTCCCATCCTATAATGCCTTTGTCAAAGAATCGAAACAAAAGATGAATGCAAGGAAAAGGAGGG CTCAGGAAGAGGCCAAAGAAGCAGAAATGAGCAGAAAGGAGTTGGGGCTTGATGAAGGCGTGGATAGCCTGAAGGCAGCCATTCAGGGGA AATCAGCCTTATGGTCCCACCTGTTACATTATCAGGACAACCGGCAGAGAAAACTCACATCAGGAAGCCTCAGTACCTCAGGAATACTTC TTGATTCAGAACGTAGGAAGTCTGATGCCAGCTCACTCATGCCTCCCCTGAGGATCTCCCTGATTCAGGATATGAGGCACATCCAGAACA TCGGGGAAATCAAGACTGATGTGGGAAAGGCCAGAGCATGGGTGCGACTGTCCATGGAAAAAAAGTTACTTTCCAGACACCTGAAGCAGC TCCTCTCAGACCATGAGCTCACCAAAAAGTTATATAAGCGCTATGCCTTCCTGCGCTGTGATGACGAGAAGGAGCAGTTCCTCTATCACC TCCTGTCTTTCAATGCCGTCGATTACTTTTGCTTCACCAATGTCTTCACAACTATCCTGATCCCGTACCACATTCTGATCGTACCAAGCA AGAAGCTGGGGGGCTCCATGTTCACTGCCAACCCATGGATCTGTATATCAGGAGAATTGGGTGAGACACAGATCATGCAGATTCCCAGGA ATGTGCTAGAGATGACCTTCGAGTGCCAGAACTTGGGGAAGCTTACTACTGTCCAGATTGGCCATGATAACTCTGGGCTGTATGCCAAAT GGCTGGTGGAGTATGTGATGGTCAGGAATGAGATCACAGGACATACCTACAAGTTCCCGTGTGGCCGGTGGTTAGGGAAGGGCATGGATG ATGGAAGCCTGGAGCGGATCCTAGTTGGGGAGCTGCTCACATCCCAGCCTGAGGTGGATGAGAGGCCATGCCGGACCCCGCCGCTGCAGC AGTCCCCCAGTGTCATCCGGAGGCTTGTTACCATCTCACCCAACAACAAGCCCAAGCTGAACACTGGGCAGATCCAGGAGTCCATCGGGG AGGCAGTCAATGGCATTGTGAAGCACTTCCATAAGCCTGAGAAAGAGCGAGGCAGTCTGACGCTGTTGCTCTGTGGAGAGTGTGGCCTTG TCTCGGCCTTGGAACAGGCTTTCCAGCATGGATTTAAATCGCCCCGGCTCTTCAAAAATGTCTTCATTTGGGATTTCCTGGAAAAAGCAC AAACCTATTATGAGACATTAGAGAAGAATGAAGTAGTCCCTGAGGAAAACTGGCATACAAGAGCCCGGAACTTCTGCCGATTTGTCACTG CAATCAACAATACTCCCCGGAACATCGGCAAGGATGGCAAGTTTCAGATGCTGGTGTGCTTGGGAGCCAGAGATCACCTCCTACACCACT GGATTGCCCTGCTGGCTGACTGCCCCATCACTGCACACATGTATGAGGATGTGGCACTGATCAAAGACCATACACTTGTCAATTCCTTGA TTCGTGTGCTGCAGACATTGCAGGAGTTCAACATCACGCTGGAGACGTCCCTTGTCAAGGGCATCGACATCTGACCTCCCAGCACCAGCC AGCAGCAGGACTGAGAAAGACTCACCCTGCAGCTCTGACCTTTTTTCCCAAAGGGACTTAAGCGATTGTGCAGGAGTAGGAGACAAAATG >In-frame_ENST00000372950_ENST00000527700_135N_DNAJC9_chr10_75003600_-_DENND5A_chr11_9173989_length(amino acids)=715AA_start in transcript=1616_stop in transcript=3763 MYPAQLGAAASSGVVSPPGMGLLDLCEEVFGTADLYRVLGVRREASDGEVRRGYHKVSLQVHPDRVGEGDKEDATRRFQILGKVYSVLSD REQRAVYDEQGTVDEDSPVLTQDRDWEAYWRLLFKKISLEDIQAFEKTYKGSEEELADIKQAYLDFKGDMDQIMESVLCVQYTEEPRIRN IIQQAIDAGEVPSYNAFVKESKQKMNARKRRAQEEAKEAEMSRKELGLDEGVDSLKAAIQGKSALWSHLLHYQDNRQRKLTSGSLSTSGI LLDSERRKSDASSLMPPLRISLIQDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLY HLLSFNAVDYFCFTNVFTTILIPYHILIVPSKKLGGSMFTANPWICISGELGETQIMQIPRNVLEMTFECQNLGKLTTVQIGHDNSGLYA KWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERILVGELLTSQPEVDERPCRTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQESI GEAVNGIVKHFHKPEKERGSLTLLLCGECGLVSALEQAFQHGFKSPRLFKNVFIWDFLEKAQTYYETLEKNEVVPEENWHTRARNFCRFV -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for DNAJC9-DENND5A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for DNAJC9-DENND5A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for DNAJC9-DENND5A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | DENND5A | C0543888 | Epileptic encephalopathy | 2 | GENOMICS_ENGLAND |
| Tgene | DENND5A | C4310635 | EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 49 | 2 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
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