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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DNER-TRIP12 (FusionGDB2 ID:23595)

Fusion Gene Summary for DNER-TRIP12

check button Fusion gene summary
Fusion gene informationFusion gene name: DNER-TRIP12
Fusion gene ID: 23595
HgeneTgene
Gene symbol

DNER

TRIP12

Gene ID

92737

9320

Gene namedelta/notch like EGF repeat containingthyroid hormone receptor interactor 12
SynonymsUNQ26|betMRD49|TRIP-12|TRIPC|ULF
Cytomap

2q36.3

2q36.3

Type of geneprotein-codingprotein-coding
Descriptiondelta and Notch-like epidermal growth factor-related receptorH_NH0150O02.1WUGSC:H_NH0150O02.1delta-notch-like EGF repeat-containing transmembraneE3 ubiquitin-protein ligase TRIP12E3 ubiquitin-protein ligase for ArfHECT-type E3 ubiquitin transferase TRIP12TR-interacting protein 12probable E3 ubiquitin-protein ligase TRIP12thyroid receptor interacting protein 12
Modification date2020031320200313
UniProtAcc

Q8NFT8

.
Ensembl transtripts involved in fusion geneENST00000341772, ENST00000482831, 
ENST00000283943, ENST00000389045, 
ENST00000389044, ENST00000543084, 
ENST00000409677, 
Fusion gene scores* DoF score3 X 3 X 2=1816 X 13 X 7=1456
# samples 318
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(18/1456*10)=-3.01594154386902
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNER [Title/Abstract] AND TRIP12 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDNER(230411663)-TRIP12(230650571), # samples:2
TRIP12(230642030)-DNER(230456604), # samples:1
TRIP12(230786596)-DNER(230456604), # samples:1
TRIP12(230786280)-DNER(230456604), # samples:1
TRIP12(230642031)-DNER(230456604), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTRIP12

GO:0000209

protein polyubiquitination

30982744

TgeneTRIP12

GO:0006511

ubiquitin-dependent protein catabolic process

18627766|20208519|30982744


check buttonFusion gene breakpoints across DNER (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TRIP12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AN-A0FJ-01ADNERchr2

230411663

-TRIP12chr2

230650571

-
ChimerDB4BRCATCGA-AN-A0FJ-01ADNERchr2

230411663

-TRIP12chr2

230650571

-


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Fusion Gene ORF analysis for DNER-TRIP12

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000341772ENST00000283943DNERchr2

230411663

-TRIP12chr2

230650571

-
In-frameENST00000341772ENST00000389045DNERchr2

230411663

-TRIP12chr2

230650571

-
In-frameENST00000341772ENST00000389044DNERchr2

230411663

-TRIP12chr2

230650571

-
5CDS-intronENST00000341772ENST00000543084DNERchr2

230411663

-TRIP12chr2

230650571

-
5CDS-intronENST00000341772ENST00000409677DNERchr2

230411663

-TRIP12chr2

230650571

-
intron-3CDSENST00000482831ENST00000283943DNERchr2

230411663

-TRIP12chr2

230650571

-
intron-3CDSENST00000482831ENST00000389045DNERchr2

230411663

-TRIP12chr2

230650571

-
intron-3CDSENST00000482831ENST00000389044DNERchr2

230411663

-TRIP12chr2

230650571

-
intron-intronENST00000482831ENST00000543084DNERchr2

230411663

-TRIP12chr2

230650571

-
intron-intronENST00000482831ENST00000409677DNERchr2

230411663

-TRIP12chr2

230650571

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000341772DNERchr2230411663-ENST00000283943TRIP12chr2230650571-605311281022336744
ENST00000341772DNERchr2230411663-ENST00000389045TRIP12chr2230650571-245011281022336744
ENST00000341772DNERchr2230411663-ENST00000389044TRIP12chr2230650571-245011281022336744

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000341772ENST00000283943DNERchr2230411663-TRIP12chr2230650571-0.0008217160.99917823
ENST00000341772ENST00000389045DNERchr2230411663-TRIP12chr2230650571-0.0180318040.9819682
ENST00000341772ENST00000389044DNERchr2230411663-TRIP12chr2230650571-0.0180318040.9819682

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Fusion Genomic Features for DNER-TRIP12


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DNER-TRIP12


check button Go to

FGviewer for the breakpoints of chr2:230411663-chr2:230650571

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNER

Q8NFT8

.
FUNCTION: Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity). {ECO:0000250}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNERchr2:230411663chr2:230650571ENST00000341772-51344_92331.0738.0DomainEGF-like 1
HgeneDNERchr2:230411663chr2:230650571ENST00000341772-51394_133331.0738.0DomainEGF-like 2
TgeneTRIP12chr2:230411663chr2:230650571ENST0000028394331411885_19921590.01993.0DomainHECT
TgeneTRIP12chr2:230411663chr2:230650571ENST0000038904432421885_19921638.02041.0DomainHECT
TgeneTRIP12chr2:230411663chr2:230650571ENST0000038904529391885_19921320.01723.0DomainHECT
TgeneTRIP12chr2:230411663chr2:230650571ENST0000038904529391496_15701320.01723.0RegionNote=K-box

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNERchr2:230411663chr2:230650571ENST00000341772-513309_348331.0738.0DomainEGF-like 3
HgeneDNERchr2:230411663chr2:230650571ENST00000341772-513349_390331.0738.0DomainEGF-like 4
HgeneDNERchr2:230411663chr2:230650571ENST00000341772-513392_428331.0738.0DomainEGF-like 5
HgeneDNERchr2:230411663chr2:230650571ENST00000341772-513430_466331.0738.0DomainEGF-like 6
HgeneDNERchr2:230411663chr2:230650571ENST00000341772-513468_503331.0738.0DomainEGF-like 7
HgeneDNERchr2:230411663chr2:230650571ENST00000341772-513505_541331.0738.0DomainEGF-like 8%3B calcium-binding
HgeneDNERchr2:230411663chr2:230650571ENST00000341772-513543_579331.0738.0DomainEGF-like 9
HgeneDNERchr2:230411663chr2:230650571ENST00000341772-513546_568331.0738.0DomainNote=Follistatin-like
HgeneDNERchr2:230411663chr2:230650571ENST00000341772-513581_617331.0738.0DomainEGF-like 10%3B calcium-binding
HgeneDNERchr2:230411663chr2:230650571ENST00000341772-51335_640331.0738.0Topological domainExtracellular
HgeneDNERchr2:230411663chr2:230650571ENST00000341772-513662_737331.0738.0Topological domainCytoplasmic
HgeneDNERchr2:230411663chr2:230650571ENST00000341772-513641_661331.0738.0TransmembraneHelical
TgeneTRIP12chr2:230411663chr2:230650571ENST000002839433141749_8361590.01993.0DomainWWE
TgeneTRIP12chr2:230411663chr2:230650571ENST000003890443242749_8361638.02041.0DomainWWE
TgeneTRIP12chr2:230411663chr2:230650571ENST000003890452939749_8361320.01723.0DomainWWE
TgeneTRIP12chr2:230411663chr2:230650571ENST0000028394331411496_15701590.01993.0RegionNote=K-box
TgeneTRIP12chr2:230411663chr2:230650571ENST0000038904432421496_15701638.02041.0RegionNote=K-box


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Fusion Gene Sequence for DNER-TRIP12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000341772_ENST00000283943_TCGA-AN-A0FJ-01A_DNER_chr2_230411663_-_TRIP12_chr2_230650571_length(transcript)=6053nt_BP=1128nt
CGCAGCTGCAGGAGGCGCCCGGCCCGGCGGAGCAGCCCTAGCCGCCACCGTCGCTCTCGCAGCTCTCGTCGCCACTGCCACCGCCGCCGC
CGTCACTGCGTCCTGGCTCCGGCTCCCGCGCCCTCCCGGCCGGCCATGCAGCCCCGCCGCGCCCAGGCGCCCGGTGCGCAGCTGCTGCCC
GCGCTGGCCCTGCTGCTGCTGCTGCTCGGAGCGGGGCCCCGAGGCAGCTCCCTGGCCAACCCGGTGCCCGCCGCGCCCCTGTCTGCGCCC
GGGCCGTGCGCCGCGCAGCCCTGCCGGAATGGGGGTGTGTGCACCTCGCGCCCTGAGCCGGACCCGCAGCACCCGGCCCCCGCCGGCGAG
CCTGGCTACAGCTGCACCTGCCCCGCCGGGATCTCCGGCGCCAACTGCCAGCTTGTTGCAGATCCTTGTGCCAGCAACCCTTGTCACCAT
GGCAACTGCAGCAGCAGCAGCAGCAGCAGCAGCGATGGCTACCTCTGCATTTGCAATGAAGGCTATGAAGGTCCCAACTGTGAACAGGCA
CTTCCCAGTCTCCCAGCCACTGGCTGGACCGAATCCATGGCACCCCGACAGCTTCAGCCTGTTCCTGCTACTCAGGAGCCTGACAAAATC
CTGCCTCGCTCTCAGGCAACGGTGACACTGCCTACCTGGCAGCCGAAAACAGGGCAGAAAGTTGTAGAAATGAAATGGGATCAAGTGGAG
GTGATCCCAGATATTGCCTGTGGGAATGCCAGTTCTAACAGCTCTGCGGGTGGCCGCCTGGTATCCTTTGAAGTGCCACAGAACACCTCA
GTCAAGATTCGGCAAGATGCCACTGCCTCACTGATTTTGCTCTGGAAGGTCACGGCCACAGGATTCCAACAGTGCTCCCTCATAGATGGA
CGAAGTGTGACCCCCCTTCAGGCTTCAGGGGGACTGGTCCTCCTGGAGGAGATGCTCGCCTTGGGGAATAATCACTTTATTGGTTTTGTG
AATGATTCTGTGACTAAGTCTATTGTGGCTTTGCGCTTAACTCTGGTGGTGAAGGTCAGCACCTGTGTGCCGGGGGAGAGTCACGCAAAT
GACTTGGAGTGTTCAGGAAAAGGAAAATGCACCACGAAGCCGTCAGAGCGTACTGTGAACCGAGAGGAGCTGCTGAAACAGGCGGAGTCT
GTGATGCAGGACCTCGGCAGCTCACGGGCCATGTTAGAAATCCAGTATGAAAATGAGGTTGGTACAGGTCTTGGGCCTACACTGGAGTTT
TATGCGCTTGTATCTCAGGAACTACAGAGAGCTGACTTGGGTCTTTGGAGAGGTGAAGAAGTAACTCTTAGCAATCCAAAAGGGAGCCAA
GAAGGGACCAAGTATATTCAAAACCTCCAGGGCCTGTTTGCGCTTCCCTTTGGTAGGACAGCAAAGCCAGCTCATATCGCAAAGGTTAAG
ATGAAGTTTCGCTTCTTAGGAAAATTAATGGCCAAGGCTATCATGGATTTCAGATTGGTGGACCTTCCCCTTGGCTTACCCTTTTATAAA
TGGATGCTACGGCAAGAAACTTCACTGACATCACACGATTTGTTTGACATCGACCCAGTTGTAGCCAGATCAGTTTATCACCTAGAAGAC
ATTGTCAGACAGAAGAAAAGACTTGAACAAGATAAATCCCAGACCAAAGAGAGTCTACAGTATGCATTAGAAACCTTGACTATGAATGGC
TGCTCAGTTGAAGATCTAGGACTGGATTTCACTCTGCCAGGGTTTCCCAATATCGAACTGAAGAAAGGAGGGAAGGATATACCAGTCACT
ATCCACAATTTAGAGGAGTATCTAAGACTGGTTATATTCTGGGCACTAAATGAAGGCGTTTCTAGGCAATTTGATTCGTTCAGAGATGGA
TTTGAATCAGTCTTCCCACTCAGTCATCTTCAGTACTTCTACCCGGAGGAACTGGATCAGCTCCTTTGTGGCAGTAAAGCAGACACTTGG
GATGCAAAGACACTGATGGAATGCTGTAGGCCTGATCATGGTTATACTCATGACAGTCGGGCTGTGAAGTTTTTGTTTGAGATTCTCAGT
AGTTTTGATAATGAGCAGCAGAGGTTATTTCTCCAGTTTGTGACTGGTAGCCCAAGATTGCCTGTTGGAGGATTCCGGAGTTTGAATCCA
CCTTTGACAATTGTCCGAAAGACGTTTGAATCAACAGAAAACCCAGATGACTTCTTGCCCTCTGTAATGACTTGTGTGAACTATCTTAAG
TTGCCGGACTATTCAAGCATTGAGATAATGCGTGAAAAACTGTTGATAGCAGCAAGAGAAGGGCAGCAGTCGTTCCATCTTTCCTGATCA
TAGCAAGAAATGCAGTGTCTGCCTGTTACAGCAAAAGAAACAAATCATGATTTCTTTTCTAATGTTATCACCTGAGTCAAGGAAACATGT
TACGCCTTCTTGTTGTAGGAAAAACGGCTTGCAGATTATAAAGAGACATTTGGTTGATATTCATTAATGGCCCCATGGACTTAAAGTGAT
CAGGCCCTAAAACGTTGTTGTGATGAGGTTTCTTTAGCAAGTTCTTGTTTAAATTATCATTTATTTGATGAGTGAAGTTTTTAACATGCT
TTGCTGTGTGAAATTTAAAAAAGGGATGTTTTTCCAGGCTGGAACAATAAATGTGGCTGTGCAGTTTAATTCTGGGCTGTGTGTATCCAT
CTAGCTAAGTCTGCAGTTTTCTTTCCTCCAAAGACAACTCTTGTACATAAGTACAGAAATTTAAGCTCACATGTATTTGACAAATATAGT
TTAGTAGACTAGCTCTATGTGCTTTTCACTTTCCTCTGATTTTCTCTCCCTGATTCATTATTATCTGTGCAGCTCACAGTTTTTTTTTTG
TATACAACTCACAGTTCTCAAATTTTCGTTACCCATGGGCTTCTGTTGTCCCATGTTCTCTCCAGTTAAGATCTAATTTAAAATTCATTG
GATTGAAATTTATTGAATATAATTCAGCTTTTGTAACTAGGTAGACTTTTCTTATAGTTTAGTTTTAATATAGTTTAGGGTATTACTGGC
TTTTTCCCAGGTGACACACTAAGGACTGTTTACATGGCAATTCCAGCAGCAACAGCCTCTGGAATGAGACAAGGAAAGCTCATTTGTTTC
TTTTATGAAGGTTAAGAAGTCTACAGCTTGGGCTGGCCGGTATTTATTATTCTGTGGCCAGAGGATTTTAAATTAATGTAAATTTTTTAA
ACAAAATAAGCAGTTTTCCTTCCCTGTTGGAGTAAAAAAATTTTTTTCCCTTTGTTGTTTTACGTTTTTGTTCATAGTCTTCTTTATTCC
ACGCTCCTCTTCCCCTTCTCCCAGTGCTGACTTGGGACAAAACAGTTCAGCCTTTGTCTCGACGCAGATAAAAGCACCTGTAAGCAATGC
TGTCCAGTCATTTTATGTGCTGATTTCTCAAATCTGCAATAATCCATCAGGTTAATGTTTTTACCTGAAAATAAAGAAAGTTTGCTTCAC
CTTTTTGTTTATAGTTTTGTGCTGTATGCATAACTTTCAATTGTATAGATGTATTTCAATGCAAGGAAATCCACATATCTCCATGATTCG
GGTCATGGCTGATTTTGCTATTCAAACAATTTATAATAGCAACTTGAAGAAACTAAAATGTGAAGAGAAAATGGGAGGAGATTCCTTCCT
AAGGTCCAAAACTAGGCCTGTGGCATAAATTTGAAGGAATTTTCCATAATTCATCTCCTTGAAAATAAGAGATGAGCTAGTTTTTTTTTT
TAATTGAACTTTGAGAAATCAATTTTTTTGACTGTTCTGTAAGTTTTAATTAATTGACACAAAAGCCCTTTTCCCTATCCCACCACCCAA
AAGAAACTCAGTGGCTTGTTTGACATAGATTGCTGTGTCAATTTACACTTAAATGGCCTTATATGGAAATGTCCCCTCCTGAGAGTTCAC
TTGGGCAGTGACCCCATTAAGTGGAAGGGAACTGTCAGAGGAGTTGGGGGCAGAGAATTCTCTCCCTGTCTCTGCAGAGACTGACAAGTG
AATGGCTTTTCCCTGAAATCCAAGAAGGGAATTGTGTTTCTGCAGTTTTCACCACTAACAGCACAGTTGCTGAGCAGCTTCATCAAGTGA
AGTTAAAGACTGAAACAATTTGTTTTCAACTGTTCTGATATCTTCCTGCAAATTAAGCACAAGGATTTTTGTGTGAACATAGCATTTTGT
TCCTGATTTTTAAAGGGTTCTGTTAAAATTTAGACATGTATAAACAAAATAATGTTTCATCTGTACTTGACATTTTATCCATGTTGCAGC
CCTGGCAAATTTGGCCTCATTGATTCCAGCATCTAATAAGTATATATGATGATTTTGACTCAAACTCTAAAGTCTTGAGTGTTTCAAAGT
CAGTCGTTACCTGTTTAAAAGCCTCAGCCTTTAGCTTATTCCTCCTTCAATACACGGGACCTTTGGTTAATTTGGGGCAGGAAAACTCTT
AAAGTAATCTCTCTTGGCAGAGGCCTTATTGCACCAGAGGGAAAAAGTATATACTTCATTTGCTGTTACTCCAGTTATGCCTTAAATTCA
TTTGCTTGGTAATCCTATCAACGAGCACTAACTTCTTAGTATACTTTAAACACTTAGTTGGGTAACAACTGAGATTTTGTTGTCCTTTAT
TTTTTGCTGAGATGGAGTCAGTCAGATGTTAGTCATAGCTAACACCGAATTTGTGTTGTCATTTAGACAGTTACTGATTCGATCTGCTTT
ATATATGAGAACGTATTTTTAACTATTCCAAGAAGGAAGAGGTAGCTAAATGTAATCCCCTCTTCCTATCCCCCCAGAAAACTGAACTGT
AAGTTCTAGGTAGACTAATTGGGAGCAGACACGGAGTTTTAGATGCCTTAGCCAAACCCAGCAGAAACCTTTCACACAGCCACTCATCGT
AAGAAACGCAGATTTTTCTCTTCTCATGCTTGTCTCTGGTTCCCTGCATTTGTAGTGACAGAACTTTCACTAGCAGGATATAAAGAAAGT
AATTATGCTTGGAGTCCCTCTTTACTGGGTTTGAGTTAGGTGCATAACATGGAAAGGAGTGGTGCCTTCAAATGAATGTGACCACTCCGT
ATTGTGGAGTGACTTCCCTAGGGCATCCTATACATCCTACCACAGAAGGCCAAGGGACAGAGCACCAACTTCAGTATCCAAGAAATTAGA
TCCACAACTCTTGATTTTCCACACTGAGGACTGTCGCGAGTAAGTTGTAAGTTTGCCGTCTTCCTTCTGGCTTAGCAGGTGCTGCAGCTG
TACTCTCGACTCCTGTCTGTGAGCGTGAGCTCAGGAAATGAGAGTGGAGTCTATTCCAAAAAAAAAATGTGATGAAGTTTTTCATAAAAG
TGCATTCATATGCCAAATCCTTTTTGGAGGATTCTGGATGCTATTGTTCATTTCTCTACTAGTAAAATGATCAAGCCTTCATTTATTTTA
GGCTTTGTTTTTTGATCCATTTTGTTTTCCCTGCTGTAATGAGAATAATTGTTTGGAAATGTCATATTCTGTATTTATGATTCTCTGAGA
AATGCTTTTGTATAAGTCTTAGGTTTGACATTGCAGTAGTTGACATACACGGTAAAGGATAACCTAGTGACAAATCACTGAAGATGCTTC
CTTTGTTACCTCAAAAAAAAAAATCCAGACAAAATAGCATTTATAAATATAGAAAACAGGATTGGCTGTTTTCCAAGAACTTCAAGTTAA
CAATTCTTATGCAAGGAAAAGTTCTTAATGCTAAAGACTTGTTCTGCATGAAGGAGACATTCTTTAATAATGGAAGAGGTGGTTTTATTT
TTACTACAAGCCGACTCATATTTCCAAACCTATAACCAATTGCTGATCTCCTGTGTAAAGCATTTTTTTCCTTTTATCTGAAACAGTGAT
TTATATGAACTGTTGGAATAATGGAACCTCAAACTACAGATGTGTATGTAAAATTGCATAAATGCACTGACTTCCTTCTCCCTGACTATA

>In-frame_ENST00000341772_ENST00000283943_TCGA-AN-A0FJ-01A_DNER_chr2_230411663_-_TRIP12_chr2_230650571_length(amino acids)=744AA_start in transcript=102_stop in transcript=2336
MAPAPAPSRPAMQPRRAQAPGAQLLPALALLLLLLGAGPRGSSLANPVPAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYS
CTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPATQEPDKILPRS
QATVTLPTWQPKTGQKVVEMKWDQVEVIPDIACGNASSNSSAGGRLVSFEVPQNTSVKIRQDATASLILLWKVTATGFQQCSLIDGRSVT
PLQASGGLVLLEEMLALGNNHFIGFVNDSVTKSIVALRLTLVVKVSTCVPGESHANDLECSGKGKCTTKPSERTVNREELLKQAESVMQD
LGSSRAMLEIQYENEVGTGLGPTLEFYALVSQELQRADLGLWRGEEVTLSNPKGSQEGTKYIQNLQGLFALPFGRTAKPAHIAKVKMKFR
FLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVE
DLGLDFTLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEELDQLLCGSKADTWDAKT
LMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDY

--------------------------------------------------------------
>In-frame_ENST00000341772_ENST00000389045_TCGA-AN-A0FJ-01A_DNER_chr2_230411663_-_TRIP12_chr2_230650571_length(transcript)=2450nt_BP=1128nt
CGCAGCTGCAGGAGGCGCCCGGCCCGGCGGAGCAGCCCTAGCCGCCACCGTCGCTCTCGCAGCTCTCGTCGCCACTGCCACCGCCGCCGC
CGTCACTGCGTCCTGGCTCCGGCTCCCGCGCCCTCCCGGCCGGCCATGCAGCCCCGCCGCGCCCAGGCGCCCGGTGCGCAGCTGCTGCCC
GCGCTGGCCCTGCTGCTGCTGCTGCTCGGAGCGGGGCCCCGAGGCAGCTCCCTGGCCAACCCGGTGCCCGCCGCGCCCCTGTCTGCGCCC
GGGCCGTGCGCCGCGCAGCCCTGCCGGAATGGGGGTGTGTGCACCTCGCGCCCTGAGCCGGACCCGCAGCACCCGGCCCCCGCCGGCGAG
CCTGGCTACAGCTGCACCTGCCCCGCCGGGATCTCCGGCGCCAACTGCCAGCTTGTTGCAGATCCTTGTGCCAGCAACCCTTGTCACCAT
GGCAACTGCAGCAGCAGCAGCAGCAGCAGCAGCGATGGCTACCTCTGCATTTGCAATGAAGGCTATGAAGGTCCCAACTGTGAACAGGCA
CTTCCCAGTCTCCCAGCCACTGGCTGGACCGAATCCATGGCACCCCGACAGCTTCAGCCTGTTCCTGCTACTCAGGAGCCTGACAAAATC
CTGCCTCGCTCTCAGGCAACGGTGACACTGCCTACCTGGCAGCCGAAAACAGGGCAGAAAGTTGTAGAAATGAAATGGGATCAAGTGGAG
GTGATCCCAGATATTGCCTGTGGGAATGCCAGTTCTAACAGCTCTGCGGGTGGCCGCCTGGTATCCTTTGAAGTGCCACAGAACACCTCA
GTCAAGATTCGGCAAGATGCCACTGCCTCACTGATTTTGCTCTGGAAGGTCACGGCCACAGGATTCCAACAGTGCTCCCTCATAGATGGA
CGAAGTGTGACCCCCCTTCAGGCTTCAGGGGGACTGGTCCTCCTGGAGGAGATGCTCGCCTTGGGGAATAATCACTTTATTGGTTTTGTG
AATGATTCTGTGACTAAGTCTATTGTGGCTTTGCGCTTAACTCTGGTGGTGAAGGTCAGCACCTGTGTGCCGGGGGAGAGTCACGCAAAT
GACTTGGAGTGTTCAGGAAAAGGAAAATGCACCACGAAGCCGTCAGAGCGTACTGTGAACCGAGAGGAGCTGCTGAAACAGGCGGAGTCT
GTGATGCAGGACCTCGGCAGCTCACGGGCCATGTTAGAAATCCAGTATGAAAATGAGGTTGGTACAGGTCTTGGGCCTACACTGGAGTTT
TATGCGCTTGTATCTCAGGAACTACAGAGAGCTGACTTGGGTCTTTGGAGAGGTGAAGAAGTAACTCTTAGCAATCCAAAAGGGAGCCAA
GAAGGGACCAAGTATATTCAAAACCTCCAGGGCCTGTTTGCGCTTCCCTTTGGTAGGACAGCAAAGCCAGCTCATATCGCAAAGGTTAAG
ATGAAGTTTCGCTTCTTAGGAAAATTAATGGCCAAGGCTATCATGGATTTCAGATTGGTGGACCTTCCCCTTGGCTTACCCTTTTATAAA
TGGATGCTACGGCAAGAAACTTCACTGACATCACACGATTTGTTTGACATCGACCCAGTTGTAGCCAGATCAGTTTATCACCTAGAAGAC
ATTGTCAGACAGAAGAAAAGACTTGAACAAGATAAATCCCAGACCAAAGAGAGTCTACAGTATGCATTAGAAACCTTGACTATGAATGGC
TGCTCAGTTGAAGATCTAGGACTGGATTTCACTCTGCCAGGGTTTCCCAATATCGAACTGAAGAAAGGAGGGAAGGATATACCAGTCACT
ATCCACAATTTAGAGGAGTATCTAAGACTGGTTATATTCTGGGCACTAAATGAAGGCGTTTCTAGGCAATTTGATTCGTTCAGAGATGGA
TTTGAATCAGTCTTCCCACTCAGTCATCTTCAGTACTTCTACCCGGAGGAACTGGATCAGCTCCTTTGTGGCAGTAAAGCAGACACTTGG
GATGCAAAGACACTGATGGAATGCTGTAGGCCTGATCATGGTTATACTCATGACAGTCGGGCTGTGAAGTTTTTGTTTGAGATTCTCAGT
AGTTTTGATAATGAGCAGCAGAGGTTATTTCTCCAGTTTGTGACTGGTAGCCCAAGATTGCCTGTTGGAGGATTCCGGAGTTTGAATCCA
CCTTTGACAATTGTCCGAAAGACGTTTGAATCAACAGAAAACCCAGATGACTTCTTGCCCTCTGTAATGACTTGTGTGAACTATCTTAAG
TTGCCGGACTATTCAAGCATTGAGATAATGCGTGAAAAACTGTTGATAGCAGCAAGAGAAGGGCAGCAGTCGTTCCATCTTTCCTGATCA
TAGCAAGAAATGCAGTGTCTGCCTGTTACAGCAAAAGAAACAAATCATGATTTCTTTTCTAATGTTATCACCTGAGTCAAGGAAACATGT

>In-frame_ENST00000341772_ENST00000389045_TCGA-AN-A0FJ-01A_DNER_chr2_230411663_-_TRIP12_chr2_230650571_length(amino acids)=744AA_start in transcript=102_stop in transcript=2336
MAPAPAPSRPAMQPRRAQAPGAQLLPALALLLLLLGAGPRGSSLANPVPAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYS
CTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPATQEPDKILPRS
QATVTLPTWQPKTGQKVVEMKWDQVEVIPDIACGNASSNSSAGGRLVSFEVPQNTSVKIRQDATASLILLWKVTATGFQQCSLIDGRSVT
PLQASGGLVLLEEMLALGNNHFIGFVNDSVTKSIVALRLTLVVKVSTCVPGESHANDLECSGKGKCTTKPSERTVNREELLKQAESVMQD
LGSSRAMLEIQYENEVGTGLGPTLEFYALVSQELQRADLGLWRGEEVTLSNPKGSQEGTKYIQNLQGLFALPFGRTAKPAHIAKVKMKFR
FLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVE
DLGLDFTLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEELDQLLCGSKADTWDAKT
LMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDY

--------------------------------------------------------------
>In-frame_ENST00000341772_ENST00000389044_TCGA-AN-A0FJ-01A_DNER_chr2_230411663_-_TRIP12_chr2_230650571_length(transcript)=2450nt_BP=1128nt
CGCAGCTGCAGGAGGCGCCCGGCCCGGCGGAGCAGCCCTAGCCGCCACCGTCGCTCTCGCAGCTCTCGTCGCCACTGCCACCGCCGCCGC
CGTCACTGCGTCCTGGCTCCGGCTCCCGCGCCCTCCCGGCCGGCCATGCAGCCCCGCCGCGCCCAGGCGCCCGGTGCGCAGCTGCTGCCC
GCGCTGGCCCTGCTGCTGCTGCTGCTCGGAGCGGGGCCCCGAGGCAGCTCCCTGGCCAACCCGGTGCCCGCCGCGCCCCTGTCTGCGCCC
GGGCCGTGCGCCGCGCAGCCCTGCCGGAATGGGGGTGTGTGCACCTCGCGCCCTGAGCCGGACCCGCAGCACCCGGCCCCCGCCGGCGAG
CCTGGCTACAGCTGCACCTGCCCCGCCGGGATCTCCGGCGCCAACTGCCAGCTTGTTGCAGATCCTTGTGCCAGCAACCCTTGTCACCAT
GGCAACTGCAGCAGCAGCAGCAGCAGCAGCAGCGATGGCTACCTCTGCATTTGCAATGAAGGCTATGAAGGTCCCAACTGTGAACAGGCA
CTTCCCAGTCTCCCAGCCACTGGCTGGACCGAATCCATGGCACCCCGACAGCTTCAGCCTGTTCCTGCTACTCAGGAGCCTGACAAAATC
CTGCCTCGCTCTCAGGCAACGGTGACACTGCCTACCTGGCAGCCGAAAACAGGGCAGAAAGTTGTAGAAATGAAATGGGATCAAGTGGAG
GTGATCCCAGATATTGCCTGTGGGAATGCCAGTTCTAACAGCTCTGCGGGTGGCCGCCTGGTATCCTTTGAAGTGCCACAGAACACCTCA
GTCAAGATTCGGCAAGATGCCACTGCCTCACTGATTTTGCTCTGGAAGGTCACGGCCACAGGATTCCAACAGTGCTCCCTCATAGATGGA
CGAAGTGTGACCCCCCTTCAGGCTTCAGGGGGACTGGTCCTCCTGGAGGAGATGCTCGCCTTGGGGAATAATCACTTTATTGGTTTTGTG
AATGATTCTGTGACTAAGTCTATTGTGGCTTTGCGCTTAACTCTGGTGGTGAAGGTCAGCACCTGTGTGCCGGGGGAGAGTCACGCAAAT
GACTTGGAGTGTTCAGGAAAAGGAAAATGCACCACGAAGCCGTCAGAGCGTACTGTGAACCGAGAGGAGCTGCTGAAACAGGCGGAGTCT
GTGATGCAGGACCTCGGCAGCTCACGGGCCATGTTAGAAATCCAGTATGAAAATGAGGTTGGTACAGGTCTTGGGCCTACACTGGAGTTT
TATGCGCTTGTATCTCAGGAACTACAGAGAGCTGACTTGGGTCTTTGGAGAGGTGAAGAAGTAACTCTTAGCAATCCAAAAGGGAGCCAA
GAAGGGACCAAGTATATTCAAAACCTCCAGGGCCTGTTTGCGCTTCCCTTTGGTAGGACAGCAAAGCCAGCTCATATCGCAAAGGTTAAG
ATGAAGTTTCGCTTCTTAGGAAAATTAATGGCCAAGGCTATCATGGATTTCAGATTGGTGGACCTTCCCCTTGGCTTACCCTTTTATAAA
TGGATGCTACGGCAAGAAACTTCACTGACATCACACGATTTGTTTGACATCGACCCAGTTGTAGCCAGATCAGTTTATCACCTAGAAGAC
ATTGTCAGACAGAAGAAAAGACTTGAACAAGATAAATCCCAGACCAAAGAGAGTCTACAGTATGCATTAGAAACCTTGACTATGAATGGC
TGCTCAGTTGAAGATCTAGGACTGGATTTCACTCTGCCAGGGTTTCCCAATATCGAACTGAAGAAAGGAGGGAAGGATATACCAGTCACT
ATCCACAATTTAGAGGAGTATCTAAGACTGGTTATATTCTGGGCACTAAATGAAGGCGTTTCTAGGCAATTTGATTCGTTCAGAGATGGA
TTTGAATCAGTCTTCCCACTCAGTCATCTTCAGTACTTCTACCCGGAGGAACTGGATCAGCTCCTTTGTGGCAGTAAAGCAGACACTTGG
GATGCAAAGACACTGATGGAATGCTGTAGGCCTGATCATGGTTATACTCATGACAGTCGGGCTGTGAAGTTTTTGTTTGAGATTCTCAGT
AGTTTTGATAATGAGCAGCAGAGGTTATTTCTCCAGTTTGTGACTGGTAGCCCAAGATTGCCTGTTGGAGGATTCCGGAGTTTGAATCCA
CCTTTGACAATTGTCCGAAAGACGTTTGAATCAACAGAAAACCCAGATGACTTCTTGCCCTCTGTAATGACTTGTGTGAACTATCTTAAG
TTGCCGGACTATTCAAGCATTGAGATAATGCGTGAAAAACTGTTGATAGCAGCAAGAGAAGGGCAGCAGTCGTTCCATCTTTCCTGATCA
TAGCAAGAAATGCAGTGTCTGCCTGTTACAGCAAAAGAAACAAATCATGATTTCTTTTCTAATGTTATCACCTGAGTCAAGGAAACATGT

>In-frame_ENST00000341772_ENST00000389044_TCGA-AN-A0FJ-01A_DNER_chr2_230411663_-_TRIP12_chr2_230650571_length(amino acids)=744AA_start in transcript=102_stop in transcript=2336
MAPAPAPSRPAMQPRRAQAPGAQLLPALALLLLLLGAGPRGSSLANPVPAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYS
CTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATGWTESMAPRQLQPVPATQEPDKILPRS
QATVTLPTWQPKTGQKVVEMKWDQVEVIPDIACGNASSNSSAGGRLVSFEVPQNTSVKIRQDATASLILLWKVTATGFQQCSLIDGRSVT
PLQASGGLVLLEEMLALGNNHFIGFVNDSVTKSIVALRLTLVVKVSTCVPGESHANDLECSGKGKCTTKPSERTVNREELLKQAESVMQD
LGSSRAMLEIQYENEVGTGLGPTLEFYALVSQELQRADLGLWRGEEVTLSNPKGSQEGTKYIQNLQGLFALPFGRTAKPAHIAKVKMKFR
FLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVE
DLGLDFTLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEELDQLLCGSKADTWDAKT
LMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DNER-TRIP12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneDNERchr2:230411663chr2:230650571ENST00000341772-51344_133331.0738.0NOTCH1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneDNERchr2:230411663chr2:230650571ENST00000341772-513677_680331.0738.0AP1G1 and somatodendritic targeting


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DNER-TRIP12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DNER-TRIP12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTRIP12C4540324MENTAL RETARDATION, AUTOSOMAL DOMINANT 492GENOMICS_ENGLAND;UNIPROT
TgeneTRIP12C0018817Atrial Septal Defects1GENOMICS_ENGLAND
TgeneTRIP12C1510586Autism Spectrum Disorders1GENOMICS_ENGLAND
TgeneTRIP12C1535926Neurodevelopmental Disorders1CTD_human
TgeneTRIP12C1862389ATRIAL SEPTAL DEFECT 11GENOMICS_ENGLAND