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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DNM3-SHISA9 (FusionGDB2 ID:23656)

Fusion Gene Summary for DNM3-SHISA9

check button Fusion gene summary
Fusion gene informationFusion gene name: DNM3-SHISA9
Fusion gene ID: 23656
HgeneTgene
Gene symbol

DNM3

SHISA9

Gene ID

26052

729993

Gene namedynamin 3shisa family member 9
SynonymsDyna IIICKAMP44
Cytomap

1q24.3

16p13.12

Type of geneprotein-codingprotein-coding
Descriptiondynamin-3T-dynamindynamin family memberdynamin, testicularprotein shisa-9cystine-knot AMPAR modulating proteinshisa homolog 9
Modification date2020031320200313
UniProtAcc

Q9UQ16

.
Ensembl transtripts involved in fusion geneENST00000358155, ENST00000367733, 
ENST00000355305, ENST00000367731, 
ENST00000520906, 		ENST00000424107, 
ENST00000558583, ENST00000558318, 
ENST00000423335, ENST00000482916, 
Fusion gene scores* DoF score9 X 7 X 5=31510 X 10 X 3=300
# samples 911
** MAII scorelog2(9/315*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/300*10)=-1.44745897697122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNM3 [Title/Abstract] AND SHISA9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDNM3(172222822)-SHISA9(13328887), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DNM3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SHISA9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A6BH-01ADNM3chr1

172222822

+SHISA9chr16

13328887

+
ChimerDB4SARCTCGA-DX-A6BH-01ADNM3chr1

172222822

-SHISA9chr16

13328887

+


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Fusion Gene ORF analysis for DNM3-SHISA9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000358155ENST00000424107DNM3chr1

172222822

+SHISA9chr16

13328887

+
Frame-shiftENST00000358155ENST00000558583DNM3chr1

172222822

+SHISA9chr16

13328887

+
5CDS-intronENST00000358155ENST00000558318DNM3chr1

172222822

+SHISA9chr16

13328887

+
5CDS-intronENST00000358155ENST00000423335DNM3chr1

172222822

+SHISA9chr16

13328887

+
5CDS-intronENST00000358155ENST00000482916DNM3chr1

172222822

+SHISA9chr16

13328887

+
intron-3CDSENST00000367733ENST00000424107DNM3chr1

172222822

+SHISA9chr16

13328887

+
intron-3CDSENST00000367733ENST00000558583DNM3chr1

172222822

+SHISA9chr16

13328887

+
intron-intronENST00000367733ENST00000558318DNM3chr1

172222822

+SHISA9chr16

13328887

+
intron-intronENST00000367733ENST00000423335DNM3chr1

172222822

+SHISA9chr16

13328887

+
intron-intronENST00000367733ENST00000482916DNM3chr1

172222822

+SHISA9chr16

13328887

+
Frame-shiftENST00000355305ENST00000424107DNM3chr1

172222822

+SHISA9chr16

13328887

+
Frame-shiftENST00000355305ENST00000558583DNM3chr1

172222822

+SHISA9chr16

13328887

+
5CDS-intronENST00000355305ENST00000558318DNM3chr1

172222822

+SHISA9chr16

13328887

+
5CDS-intronENST00000355305ENST00000423335DNM3chr1

172222822

+SHISA9chr16

13328887

+
5CDS-intronENST00000355305ENST00000482916DNM3chr1

172222822

+SHISA9chr16

13328887

+
Frame-shiftENST00000367731ENST00000424107DNM3chr1

172222822

+SHISA9chr16

13328887

+
Frame-shiftENST00000367731ENST00000558583DNM3chr1

172222822

+SHISA9chr16

13328887

+
5CDS-intronENST00000367731ENST00000558318DNM3chr1

172222822

+SHISA9chr16

13328887

+
5CDS-intronENST00000367731ENST00000423335DNM3chr1

172222822

+SHISA9chr16

13328887

+
5CDS-intronENST00000367731ENST00000482916DNM3chr1

172222822

+SHISA9chr16

13328887

+
Frame-shiftENST00000520906ENST00000424107DNM3chr1

172222822

+SHISA9chr16

13328887

+
Frame-shiftENST00000520906ENST00000558583DNM3chr1

172222822

+SHISA9chr16

13328887

+
5CDS-intronENST00000520906ENST00000558318DNM3chr1

172222822

+SHISA9chr16

13328887

+
5CDS-intronENST00000520906ENST00000423335DNM3chr1

172222822

+SHISA9chr16

13328887

+
5CDS-intronENST00000520906ENST00000482916DNM3chr1

172222822

+SHISA9chr16

13328887

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for DNM3-SHISA9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DNM3chr1172222822+SHISA9chr1613328886+0.59642040.4035796
DNM3chr1172222822+SHISA9chr1613328886+0.59642040.4035796

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DNM3-SHISA9


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNM3

Q9UQ16

.
FUNCTION: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity). {ECO:0000250}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for DNM3-SHISA9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for DNM3-SHISA9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DNM3-SHISA9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DNM3-SHISA9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDNM3C0022665Kidney Neoplasm1CTD_human
HgeneDNM3C0740457Malignant neoplasm of kidney1CTD_human