FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:DNM3-TPH2 (FusionGDB2 ID:23657)

Fusion Gene Summary for DNM3-TPH2

check button Fusion gene summary
Fusion gene informationFusion gene name: DNM3-TPH2
Fusion gene ID: 23657
HgeneTgene
Gene symbol

DNM3

TPH2

Gene ID

26052

121278

Gene namedynamin 3tryptophan hydroxylase 2
SynonymsDyna IIIADHD7|NTPH
Cytomap

1q24.3

12q21.1

Type of geneprotein-codingprotein-coding
Descriptiondynamin-3T-dynamindynamin family memberdynamin, testiculartryptophan 5-hydroxylase 2neuronal tryptophan hydroxylasetryptophan 5-monooxygenase 2
Modification date2020031320200313
UniProtAcc

Q9UQ16

.
Ensembl transtripts involved in fusion geneENST00000358155, ENST00000367733, 
ENST00000355305, ENST00000367731, 
ENST00000520906, 		ENST00000333850, 
ENST00000546576, 
Fusion gene scores* DoF score9 X 7 X 5=3158 X 6 X 4=192
# samples 97
** MAII scorelog2(9/315*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/192*10)=-1.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DNM3 [Title/Abstract] AND TPH2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDNM3(172222822)-TPH2(72388219), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DNM3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TPH2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A3U6-01ADNM3chr1

172222822

+TPH2chr12

72388219

+
ChimerDB4SARCTCGA-DX-A3U6-01ADNM3chr1

172222822

+TPH2chr12

72388219

+
ChimerDB4SARCTCGA-DX-A3U6-01ADNM3chr1

172222822

-TPH2chr12

72388219

+


Top

Fusion Gene ORF analysis for DNM3-TPH2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000358155ENST00000333850DNM3chr1

172222822

+TPH2chr12

72388219

+
5CDS-intronENST00000358155ENST00000546576DNM3chr1

172222822

+TPH2chr12

72388219

+
intron-3CDSENST00000367733ENST00000333850DNM3chr1

172222822

+TPH2chr12

72388219

+
intron-intronENST00000367733ENST00000546576DNM3chr1

172222822

+TPH2chr12

72388219

+
In-frameENST00000355305ENST00000333850DNM3chr1

172222822

+TPH2chr12

72388219

+
5CDS-intronENST00000355305ENST00000546576DNM3chr1

172222822

+TPH2chr12

72388219

+
In-frameENST00000367731ENST00000333850DNM3chr1

172222822

+TPH2chr12

72388219

+
5CDS-intronENST00000367731ENST00000546576DNM3chr1

172222822

+TPH2chr12

72388219

+
In-frameENST00000520906ENST00000333850DNM3chr1

172222822

+TPH2chr12

72388219

+
5CDS-intronENST00000520906ENST00000546576DNM3chr1

172222822

+TPH2chr12

72388219

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358155DNM3chr1172222822+ENST00000333850TPH2chr1272388219+322319451522476774
ENST00000355305DNM3chr1172222822+ENST00000333850TPH2chr1272388219+323419561332487784
ENST00000367731DNM3chr1172222822+ENST00000333850TPH2chr1272388219+320419261332457774
ENST00000520906DNM3chr1172222822+ENST00000333850TPH2chr1272388219+317518971042428774

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358155ENST00000333850DNM3chr1172222822+TPH2chr1272388219+0.0021671710.99783283
ENST00000355305ENST00000333850DNM3chr1172222822+TPH2chr1272388219+0.0021374690.9978625
ENST00000367731ENST00000333850DNM3chr1172222822+TPH2chr1272388219+0.0022033570.99779665
ENST00000520906ENST00000333850DNM3chr1172222822+TPH2chr1272388219+0.0021363850.9978636

Top

Fusion Genomic Features for DNM3-TPH2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DNM3chr1172222822+TPH2chr1272388218+0.0002033180.9997967
DNM3chr1172222822+TPH2chr1272388218+0.0002033180.9997967

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for DNM3-TPH2


check button Go to

FGviewer for the breakpoints of chr1:172222822-chr12:72388219

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DNM3

Q9UQ16

.
FUNCTION: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity). {ECO:0000250}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNM3chr1:172222822chr12:72388219ENST00000355305+162128_294599.6666666666666870.0DomainDynamin-type G
HgeneDNM3chr1:172222822chr12:72388219ENST00000358155+152128_294589.6666666666666864.0DomainDynamin-type G
HgeneDNM3chr1:172222822chr12:72388219ENST00000367731+152028_294589.6666666666666860.0DomainDynamin-type G
HgeneDNM3chr1:172222822chr12:72388219ENST00000355305+1621205_211599.6666666666666870.0Nucleotide bindingGTP
HgeneDNM3chr1:172222822chr12:72388219ENST00000355305+1621236_239599.6666666666666870.0Nucleotide bindingGTP
HgeneDNM3chr1:172222822chr12:72388219ENST00000355305+162138_46599.6666666666666870.0Nucleotide bindingGTP
HgeneDNM3chr1:172222822chr12:72388219ENST00000358155+1521205_211589.6666666666666864.0Nucleotide bindingGTP
HgeneDNM3chr1:172222822chr12:72388219ENST00000358155+1521236_239589.6666666666666864.0Nucleotide bindingGTP
HgeneDNM3chr1:172222822chr12:72388219ENST00000358155+152138_46589.6666666666666864.0Nucleotide bindingGTP
HgeneDNM3chr1:172222822chr12:72388219ENST00000367731+1520205_211589.6666666666666860.0Nucleotide bindingGTP
HgeneDNM3chr1:172222822chr12:72388219ENST00000367731+1520236_239589.6666666666666860.0Nucleotide bindingGTP
HgeneDNM3chr1:172222822chr12:72388219ENST00000367731+152038_46589.6666666666666860.0Nucleotide bindingGTP
HgeneDNM3chr1:172222822chr12:72388219ENST00000355305+1621136_139599.6666666666666870.0RegionG3 motif
HgeneDNM3chr1:172222822chr12:72388219ENST00000355305+1621205_208599.6666666666666870.0RegionG4 motif
HgeneDNM3chr1:172222822chr12:72388219ENST00000355305+1621235_238599.6666666666666870.0RegionG5 motif
HgeneDNM3chr1:172222822chr12:72388219ENST00000355305+162138_45599.6666666666666870.0RegionG1 motif
HgeneDNM3chr1:172222822chr12:72388219ENST00000355305+162164_66599.6666666666666870.0RegionG2 motif
HgeneDNM3chr1:172222822chr12:72388219ENST00000358155+1521136_139589.6666666666666864.0RegionG3 motif
HgeneDNM3chr1:172222822chr12:72388219ENST00000358155+1521205_208589.6666666666666864.0RegionG4 motif
HgeneDNM3chr1:172222822chr12:72388219ENST00000358155+1521235_238589.6666666666666864.0RegionG5 motif
HgeneDNM3chr1:172222822chr12:72388219ENST00000358155+152138_45589.6666666666666864.0RegionG1 motif
HgeneDNM3chr1:172222822chr12:72388219ENST00000358155+152164_66589.6666666666666864.0RegionG2 motif
HgeneDNM3chr1:172222822chr12:72388219ENST00000367731+1520136_139589.6666666666666860.0RegionG3 motif
HgeneDNM3chr1:172222822chr12:72388219ENST00000367731+1520205_208589.6666666666666860.0RegionG4 motif
HgeneDNM3chr1:172222822chr12:72388219ENST00000367731+1520235_238589.6666666666666860.0RegionG5 motif
HgeneDNM3chr1:172222822chr12:72388219ENST00000367731+152038_45589.6666666666666860.0RegionG1 motif
HgeneDNM3chr1:172222822chr12:72388219ENST00000367731+152064_66589.6666666666666860.0RegionG2 motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNM3chr1:172222822chr12:72388219ENST00000355305+1621515_621599.6666666666666870.0DomainPH
HgeneDNM3chr1:172222822chr12:72388219ENST00000355305+1621659_750599.6666666666666870.0DomainGED
HgeneDNM3chr1:172222822chr12:72388219ENST00000358155+1521515_621589.6666666666666864.0DomainPH
HgeneDNM3chr1:172222822chr12:72388219ENST00000358155+1521659_750589.6666666666666864.0DomainGED
HgeneDNM3chr1:172222822chr12:72388219ENST00000367731+1520515_621589.6666666666666860.0DomainPH
HgeneDNM3chr1:172222822chr12:72388219ENST00000367731+1520659_750589.6666666666666860.0DomainGED
TgeneTPH2chr1:172222822chr12:72388219ENST0000033385061165_140313.6666666666667491.0DomainACT


Top

Fusion Gene Sequence for DNM3-TPH2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000358155_ENST00000333850_TCGA-DX-A3U6-01A_DNM3_chr1_172222822_+_TPH2_chr12_72388219_length(transcript)=3223nt_BP=1945nt
GCGGGTCGTTAGCTGTCAGAGCCAAGCGGCGGGCTGGCGGCGGGCTCCGACGTCTGCGCCAGGACCTGGCTGGCTGAGCCCGGCGCAGCA
GCAGCAGCCAGGGCAGCGCGGCCCCTACTCCCTGTCAGGTCGTAGAGGCGAGCAGGGACCAGCTGGTCGCCGGCCCCTCGGGCAAGATGG
GGAACCGGGAGATGGAGGAGCTGATCCCGCTGGTGAACCGTCTGCAGGACGCGTTTTCGGCGCTGGGACAGAGCTGCCTGCTGGAGCTGC
CGCAGATCGCCGTGGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGCTCGAGAACTTCGTGGGCAGGGACTTTCTCCCTCGAGGGTCGG
GCATTGTAACAAGACGACCTCTTGTGCTGCAGCTTGTTACTTCTAAAGCAGAATATGCCGAGTTTCTACATTGCAAAGGAAAGAAATTTA
CAGATTTTGATGAAGTTCGCCTTGAGATTGAAGCAGAAACAGATCGCGTGACTGGAATGAATAAAGGCATTTCCTCCATACCCATTAATT
TACGAGTCTATTCCCCACACGTGTTAAATCTAACCCTTATTGATCTACCTGGAATAACTAAAGTGCCTGTGGGAGATCAGCCACCAGATA
TCGAGTATCAGATCAGAGAAATGATTATGCAGTTCATCACGAGGGAGAACTGTCTGATTTTAGCTGTTACTCCAGCCAACACTGATCTTG
CAAACTCAGATGCGCTGAAGCTAGCTAAAGAAGTTGATCCTCAAGGTCTGAGAACCATTGGAGTTATCACCAAACTGGACCTTATGGATG
AAGGAACGGATGCCAGGGATGTTCTAGAGAACAAACTGTTGCCTCTTCGCAGGGGTTACGTGGGGGTGGTAAACAGAAGCCAGAAGGACA
TAGATGGGAAGAAGGACATAAAGGCAGCCATGCTGGCAGAGAGGAAGTTTTTCCTTTCCCACCCGGCTTACAGACATATCGCTGACCGAA
TGGGAACCCCACACCTGCAGAAGGTCCTTAATCAGCAACTTACCAACCACATTCGGGATACCCTACCAAACTTCAGGAACAAACTACAGG
GACAGTTGCTCTCCATAGAACATGAAGTAGAAGCCTACAAAAATTTCAAACCAGAAGACCCAACAAGGAAGACCAAAGCATTGCTGCAGA
TGGTTCAGCAATTTGCTGTGGACTTTGAGAAGAGAATTGAAGGGTCAGGGGATCAAGTAGATACCCTGGAACTCTCAGGTGGTGCTAAAA
TCAATCGTATTTTTCATGAACGCTTTCCTTTTGAGATAGTAAAGATGGAGTTCAATGAGAAAGAATTGCGAAGAGAAATAAGCTATGCAA
TCAAAAACATACATGGTATCAGGACAGGGTTGTTTACTCCAGACATGGCATTTGAAGCGATAGTCAAGAAACAGATTGTAAAGTTGAAAG
GGCCTTCCTTGAAGAGTGTGGATCTGGTAATACAAGAATTAATCAACACTGTGAAGAAGTGTACCAAAAAACTGGCAAACTTCCCCAGAC
TCTGCGAGGAAACGGAAAGGATTGTTGCTAACCACATTCGTGAGCGAGAAGGGAAGACAAAGGACCAGGTATTGCTATTGATTGACATTC
AAGTCTCTTACATCAACACCAACCATGAAGACTTCATTGGCTTCGCAAATGCTCAGCAGAGGAGCAGTCAGGTTCACAAGAAAACCACAG
TTGGAAATCAGGTGATTCGCAAGGGGTGGCTCACCATCAGCAACATTGGCATCATGAAAGGCGGCTCGAAGGGATACTGGTTCGTCCTTA
CTGCGGAAAGCTTGTCCTGGTATAAAGATGATGAGGAAAAAGAAAAGAAGTACATGCTTCCCTTGGACAACCTGAAAGTTCGGGATGTGG
AAAAGAGCTTTATGTCTAGCAAGCACATCTTTGCACTCTTTAATACAGAGCAAAGAGACACATGCCATGAACTCTTGGGACATGTTCCAC
TACTTGCGGATCCTAAGTTTGCTCAGTTTTCACAAGAAATAGGTCTGGCGTCTCTGGGAGCATCAGATGAAGATGTTCAGAAACTAGCCA
CGTGCTATTTCTTCACAATCGAGTTTGGCCTTTGCAAGCAAGAAGGGCAACTGCGGGCATATGGAGCAGGACTCCTTTCCTCCATTGGAG
AATTAAAGCACGCCCTTTCTGACAAGGCATGTGTGAAAGCCTTTGACCCAAAGACAACTTGCTTACAGGAATGCCTTATCACCACCTTCC
AGGAAGCCTACTTTGTTTCAGAAAGTTTTGAAGAAGCCAAAGAAAAGATGAGGGACTTTGCAAAGTCAATTACCCGTCCCTTCTCAGTAT
ACTTCAATCCCTACACACAGAGTATTGAAATTCTGAAAGACACCAGAAGTATTGAAAATGTGGTGCAGGACCTTCGCAGCGACTTGAATA
CAGTGTGTGATGCTTTAAACAAAATGAACCAATATCTGGGGATTTGATGCCTGGAACTATGTTGTTGCCAGCATGATCTTTTTGGGGCTT
AGCAGCAGTTCAGTCAATGTCATATAACGCAAATAACCTTCTGTGTCATGGCTTGGCTAATAAGCATGCAATTCCATATATCTATACCAT
CTTGTAACTCACTGTGTTAGTATATAAAGCACCATAAGAAATCCAATGGCAGATAACCACTCATTGTATGAAATAACGTATTATGTTTAA
ACATCTTAAAAAGATTTGACATTCCTGCTTAGTGTCCTTAACCAAACTGCATCTAGTTAAAATTTGTAACAAATAGCCCTCTTATGAGTC
TCATTTATGCCCTTTTCTTTTTCAGATCTAAGCCTTTCCTCTGTGTTCATTAGATAAAATGAAAAAAAGCAGTGAAGCTGTTTCCATTTT
CAATAGTATCAGTGTTTTCACGCATTATTTGAGATAAACCCAGAATTGTAGGAAACTTCCCATCACAATAACAAAGGTTCAATATTCTAT
TTCAAAAATTGTTGAGGTAACACAGCAGTTGGAATGATTTTTAGGTTGAGTATTTACACAATGCAAGAAAACACCTTTTTACAAATGGAA
TTATGTAGGTTGCGTTGACCTTGTAGAACCTGAGTTATGACAAGCTTCCTGAAGTATTTTGGAAGATAGTACTTCCGGAAAGGACATTAG

>In-frame_ENST00000358155_ENST00000333850_TCGA-DX-A3U6-01A_DNM3_chr1_172222822_+_TPH2_chr12_72388219_length(amino acids)=774AA_start in transcript=152_stop in transcript=2476
MVAGPSGKMGNREMEELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLVLQLVTSKAEYAE
FLHCKGKKFTDFDEVRLEIEAETDRVTGMNKGISSIPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIREMIMQFITRENCLIL
AVTPANTDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYVGVVNRSQKDIDGKKDIKAAMLAERKFFLSH
PAYRHIADRMGTPHLQKVLNQQLTNHIRDTLPNFRNKLQGQLLSIEHEVEAYKNFKPEDPTRKTKALLQMVQQFAVDFEKRIEGSGDQVD
TLELSGGAKINRIFHERFPFEIVKMEFNEKELRREISYAIKNIHGIRTGLFTPDMAFEAIVKKQIVKLKGPSLKSVDLVIQELINTVKKC
TKKLANFPRLCEETERIVANHIREREGKTKDQVLLLIDIQVSYINTNHEDFIGFANAQQRSSQVHKKTTVGNQVIRKGWLTISNIGIMKG
GSKGYWFVLTAESLSWYKDDEEKEKKYMLPLDNLKVRDVEKSFMSSKHIFALFNTEQRDTCHELLGHVPLLADPKFAQFSQEIGLASLGA
SDEDVQKLATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYFVSESFEEAKEKMRDFA

--------------------------------------------------------------
>In-frame_ENST00000355305_ENST00000333850_TCGA-DX-A3U6-01A_DNM3_chr1_172222822_+_TPH2_chr12_72388219_length(transcript)=3234nt_BP=1956nt
AGCCAAGCGGCGGGCTGGCGGCGGGCTCCGACGTCTGCGCCAGGACCTGGCTGGCTGAGCCCGGCGCAGCAGCAGCAGCCAGGGCAGCGC
GGCCCCTACTCCCTGTCAGGTCGTAGAGGCGAGCAGGGACCAGCTGGTCGCCGGCCCCTCGGGCAAGATGGGGAACCGGGAGATGGAGGA
GCTGATCCCGCTGGTGAACCGTCTGCAGGACGCGTTTTCGGCGCTGGGACAGAGCTGCCTGCTGGAGCTGCCGCAGATCGCCGTGGTGGG
CGGCCAGAGCGCCGGCAAGAGCTCGGTGCTCGAGAACTTCGTGGGCAGGGACTTTCTCCCTCGAGGGTCGGGCATTGTAACAAGACGACC
TCTTGTGCTGCAGCTTGTTACTTCTAAAGCAGAATATGCCGAGTTTCTACATTGCAAAGGAAAGAAATTTACAGATTTTGATGAAGTTCG
CCTTGAGATTGAAGCAGAAACAGATCGCGTGACTGGAATGAATAAAGGCATTTCCTCCATACCCATTAATTTACGAGTCTATTCCCCACA
CGTGTTAAATCTAACCCTTATTGATCTACCTGGAATAACTAAAGTGCCTGTGGGAGATCAGCCACCAGATATCGAGTATCAGATCAGAGA
AATGATTATGCAGTTCATCACGAGGGAGAACTGTCTGATTTTAGCTGTTACTCCAGCCAACACTGATCTTGCAAACTCAGATGCGCTGAA
GCTAGCTAAAGAAGTTGATCCTCAAGGTCTGAGAACCATTGGAGTTATCACCAAACTGGACCTTATGGATGAAGGAACGGATGCCAGGGA
TGTTCTAGAGAACAAACTGTTGCCTCTTCGCAGGGGTTACGTGGGGGTGGTAAACAGAAGCCAGAAGGACATAGATGGGAAGAAGGACAT
AAAGGCAGCCATGCTGGCAGAGAGGAAGTTTTTCCTTTCCCACCCGGCTTACAGACATATCGCTGACCGAATGGGAACCCCACACCTGCA
GAAGGTCCTTAATCAGCAACTTACCAACCACATTCGGGATACCCTACCAAACTTCAGGAACAAACTACAGGGACAGTTGCTCTCCATAGA
ACATGAAGTAGAAGCCTACAAAAATTTCAAACCAGAAGACCCAACAAGGAAGACCAAAGCATTGCTGCAGATGGTTCAGCAATTTGCTGT
GGACTTTGAGAAGAGAATTGAAGGGTCAGGGGATCAAGTAGATACCCTGGAACTCTCAGGTGGTGCTAAAATCAATCGTATTTTTCATGA
ACGCTTTCCTTTTGAGATAGTAAAGATGGAGTTCAATGAGAAAGAATTGCGAAGAGAAATAAGCTATGCAATCAAAAACATACATGGTAT
CAGGACAGGGTTGTTTACTCCAGACATGGCATTTGAAGCGATAGTCAAGAAACAGATTGTAAAGTTGAAAGGGCCTTCCTTGAAGAGTGT
GGATCTGGTAATACAAGAATTAATCAACACTGTGAAGAAGTGTACCAAAAAACTGGCAAACTTCCCCAGACTCTGCGAGGAAACGGAAAG
GATTGTTGCTAACCACATTCGTGAGCGAGAAGGGAAGACAAAGGACCAGGTATTGCTATTGATTGACATTCAAGTCTCTTACATCAACAC
CAACCATGAAGACTTCATTGGCTTCGCAAATGCTCAGCAGAGGAGCAGTCAGGTTCACAAGAAAACCACAGTTGGAAATCAGGGAACCAA
TCTTCCGCCTTCAAGGCAAATTGTGATTCGCAAGGGGTGGCTCACCATCAGCAACATTGGCATCATGAAAGGCGGCTCGAAGGGATACTG
GTTCGTCCTTACTGCGGAAAGCTTGTCCTGGTATAAAGATGATGAGGAAAAAGAAAAGAAGTACATGCTTCCCTTGGACAACCTGAAAGT
TCGGGATGTGGAAAAGAGCTTTATGTCTAGCAAGCACATCTTTGCACTCTTTAATACAGAGCAAAGAGACACATGCCATGAACTCTTGGG
ACATGTTCCACTACTTGCGGATCCTAAGTTTGCTCAGTTTTCACAAGAAATAGGTCTGGCGTCTCTGGGAGCATCAGATGAAGATGTTCA
GAAACTAGCCACGTGCTATTTCTTCACAATCGAGTTTGGCCTTTGCAAGCAAGAAGGGCAACTGCGGGCATATGGAGCAGGACTCCTTTC
CTCCATTGGAGAATTAAAGCACGCCCTTTCTGACAAGGCATGTGTGAAAGCCTTTGACCCAAAGACAACTTGCTTACAGGAATGCCTTAT
CACCACCTTCCAGGAAGCCTACTTTGTTTCAGAAAGTTTTGAAGAAGCCAAAGAAAAGATGAGGGACTTTGCAAAGTCAATTACCCGTCC
CTTCTCAGTATACTTCAATCCCTACACACAGAGTATTGAAATTCTGAAAGACACCAGAAGTATTGAAAATGTGGTGCAGGACCTTCGCAG
CGACTTGAATACAGTGTGTGATGCTTTAAACAAAATGAACCAATATCTGGGGATTTGATGCCTGGAACTATGTTGTTGCCAGCATGATCT
TTTTGGGGCTTAGCAGCAGTTCAGTCAATGTCATATAACGCAAATAACCTTCTGTGTCATGGCTTGGCTAATAAGCATGCAATTCCATAT
ATCTATACCATCTTGTAACTCACTGTGTTAGTATATAAAGCACCATAAGAAATCCAATGGCAGATAACCACTCATTGTATGAAATAACGT
ATTATGTTTAAACATCTTAAAAAGATTTGACATTCCTGCTTAGTGTCCTTAACCAAACTGCATCTAGTTAAAATTTGTAACAAATAGCCC
TCTTATGAGTCTCATTTATGCCCTTTTCTTTTTCAGATCTAAGCCTTTCCTCTGTGTTCATTAGATAAAATGAAAAAAAGCAGTGAAGCT
GTTTCCATTTTCAATAGTATCAGTGTTTTCACGCATTATTTGAGATAAACCCAGAATTGTAGGAAACTTCCCATCACAATAACAAAGGTT
CAATATTCTATTTCAAAAATTGTTGAGGTAACACAGCAGTTGGAATGATTTTTAGGTTGAGTATTTACACAATGCAAGAAAACACCTTTT
TACAAATGGAATTATGTAGGTTGCGTTGACCTTGTAGAACCTGAGTTATGACAAGCTTCCTGAAGTATTTTGGAAGATAGTACTTCCGGA

>In-frame_ENST00000355305_ENST00000333850_TCGA-DX-A3U6-01A_DNM3_chr1_172222822_+_TPH2_chr12_72388219_length(amino acids)=784AA_start in transcript=133_stop in transcript=2487
MVAGPSGKMGNREMEELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLVLQLVTSKAEYAE
FLHCKGKKFTDFDEVRLEIEAETDRVTGMNKGISSIPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIREMIMQFITRENCLIL
AVTPANTDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYVGVVNRSQKDIDGKKDIKAAMLAERKFFLSH
PAYRHIADRMGTPHLQKVLNQQLTNHIRDTLPNFRNKLQGQLLSIEHEVEAYKNFKPEDPTRKTKALLQMVQQFAVDFEKRIEGSGDQVD
TLELSGGAKINRIFHERFPFEIVKMEFNEKELRREISYAIKNIHGIRTGLFTPDMAFEAIVKKQIVKLKGPSLKSVDLVIQELINTVKKC
TKKLANFPRLCEETERIVANHIREREGKTKDQVLLLIDIQVSYINTNHEDFIGFANAQQRSSQVHKKTTVGNQGTNLPPSRQIVIRKGWL
TISNIGIMKGGSKGYWFVLTAESLSWYKDDEEKEKKYMLPLDNLKVRDVEKSFMSSKHIFALFNTEQRDTCHELLGHVPLLADPKFAQFS
QEIGLASLGASDEDVQKLATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYFVSESFE

--------------------------------------------------------------
>In-frame_ENST00000367731_ENST00000333850_TCGA-DX-A3U6-01A_DNM3_chr1_172222822_+_TPH2_chr12_72388219_length(transcript)=3204nt_BP=1926nt
AGCCAAGCGGCGGGCTGGCGGCGGGCTCCGACGTCTGCGCCAGGACCTGGCTGGCTGAGCCCGGCGCAGCAGCAGCAGCCAGGGCAGCGC
GGCCCCTACTCCCTGTCAGGTCGTAGAGGCGAGCAGGGACCAGCTGGTCGCCGGCCCCTCGGGCAAGATGGGGAACCGGGAGATGGAGGA
GCTGATCCCGCTGGTGAACCGTCTGCAGGACGCGTTTTCGGCGCTGGGACAGAGCTGCCTGCTGGAGCTGCCGCAGATCGCCGTGGTGGG
CGGCCAGAGCGCCGGCAAGAGCTCGGTGCTCGAGAACTTCGTGGGCAGGGACTTTCTCCCTCGAGGGTCGGGCATTGTAACAAGACGACC
TCTTGTGCTGCAGCTTGTTACTTCTAAAGCAGAATATGCCGAGTTTCTACATTGCAAAGGAAAGAAATTTACAGATTTTGATGAAGTTCG
CCTTGAGATTGAAGCAGAAACAGATCGCGTGACTGGAATGAATAAAGGCATTTCCTCCATACCCATTAATTTACGAGTCTATTCCCCACA
CGTGTTAAATCTAACCCTTATTGATCTACCTGGAATAACTAAAGTGCCTGTGGGAGATCAGCCACCAGATATCGAGTATCAGATCAGAGA
AATGATTATGCAGTTCATCACGAGGGAGAACTGTCTGATTTTAGCTGTTACTCCAGCCAACACTGATCTTGCAAACTCAGATGCGCTGAA
GCTAGCTAAAGAAGTTGATCCTCAAGGTCTGAGAACCATTGGAGTTATCACCAAACTGGACCTTATGGATGAAGGAACGGATGCCAGGGA
TGTTCTAGAGAACAAACTGTTGCCTCTTCGCAGGGGTTACGTGGGGGTGGTAAACAGAAGCCAGAAGGACATAGATGGGAAGAAGGACAT
AAAGGCAGCCATGCTGGCAGAGAGGAAGTTTTTCCTTTCCCACCCGGCTTACAGACATATCGCTGACCGAATGGGAACCCCACACCTGCA
GAAGGTCCTTAATCAGCAACTTACCAACCACATTCGGGATACCCTACCAAACTTCAGGAACAAACTACAGGGACAGTTGCTCTCCATAGA
ACATGAAGTAGAAGCCTACAAAAATTTCAAACCAGAAGACCCAACAAGGAAGACCAAAGCATTGCTGCAGATGGTTCAGCAATTTGCTGT
GGACTTTGAGAAGAGAATTGAAGGGTCAGGGGATCAAGTAGATACCCTGGAACTCTCAGGTGGTGCTAAAATCAATCGTATTTTTCATGA
ACGCTTTCCTTTTGAGATAGTAAAGATGGAGTTCAATGAGAAAGAATTGCGAAGAGAAATAAGCTATGCAATCAAAAACATACATGGTAT
CAGGACAGGGTTGTTTACTCCAGACATGGCATTTGAAGCGATAGTCAAGAAACAGATTGTAAAGTTGAAAGGGCCTTCCTTGAAGAGTGT
GGATCTGGTAATACAAGAATTAATCAACACTGTGAAGAAGTGTACCAAAAAACTGGCAAACTTCCCCAGACTCTGCGAGGAAACGGAAAG
GATTGTTGCTAACCACATTCGTGAGCGAGAAGGGAAGACAAAGGACCAGGTATTGCTATTGATTGACATTCAAGTCTCTTACATCAACAC
CAACCATGAAGACTTCATTGGCTTCGCAAATGCTCAGCAGAGGAGCAGTCAGGTTCACAAGAAAACCACAGTTGGAAATCAGGTGATTCG
CAAGGGGTGGCTCACCATCAGCAACATTGGCATCATGAAAGGCGGCTCGAAGGGATACTGGTTCGTCCTTACTGCGGAAAGCTTGTCCTG
GTATAAAGATGATGAGGAAAAAGAAAAGAAGTACATGCTTCCCTTGGACAACCTGAAAGTTCGGGATGTGGAAAAGAGCTTTATGTCTAG
CAAGCACATCTTTGCACTCTTTAATACAGAGCAAAGAGACACATGCCATGAACTCTTGGGACATGTTCCACTACTTGCGGATCCTAAGTT
TGCTCAGTTTTCACAAGAAATAGGTCTGGCGTCTCTGGGAGCATCAGATGAAGATGTTCAGAAACTAGCCACGTGCTATTTCTTCACAAT
CGAGTTTGGCCTTTGCAAGCAAGAAGGGCAACTGCGGGCATATGGAGCAGGACTCCTTTCCTCCATTGGAGAATTAAAGCACGCCCTTTC
TGACAAGGCATGTGTGAAAGCCTTTGACCCAAAGACAACTTGCTTACAGGAATGCCTTATCACCACCTTCCAGGAAGCCTACTTTGTTTC
AGAAAGTTTTGAAGAAGCCAAAGAAAAGATGAGGGACTTTGCAAAGTCAATTACCCGTCCCTTCTCAGTATACTTCAATCCCTACACACA
GAGTATTGAAATTCTGAAAGACACCAGAAGTATTGAAAATGTGGTGCAGGACCTTCGCAGCGACTTGAATACAGTGTGTGATGCTTTAAA
CAAAATGAACCAATATCTGGGGATTTGATGCCTGGAACTATGTTGTTGCCAGCATGATCTTTTTGGGGCTTAGCAGCAGTTCAGTCAATG
TCATATAACGCAAATAACCTTCTGTGTCATGGCTTGGCTAATAAGCATGCAATTCCATATATCTATACCATCTTGTAACTCACTGTGTTA
GTATATAAAGCACCATAAGAAATCCAATGGCAGATAACCACTCATTGTATGAAATAACGTATTATGTTTAAACATCTTAAAAAGATTTGA
CATTCCTGCTTAGTGTCCTTAACCAAACTGCATCTAGTTAAAATTTGTAACAAATAGCCCTCTTATGAGTCTCATTTATGCCCTTTTCTT
TTTCAGATCTAAGCCTTTCCTCTGTGTTCATTAGATAAAATGAAAAAAAGCAGTGAAGCTGTTTCCATTTTCAATAGTATCAGTGTTTTC
ACGCATTATTTGAGATAAACCCAGAATTGTAGGAAACTTCCCATCACAATAACAAAGGTTCAATATTCTATTTCAAAAATTGTTGAGGTA
ACACAGCAGTTGGAATGATTTTTAGGTTGAGTATTTACACAATGCAAGAAAACACCTTTTTACAAATGGAATTATGTAGGTTGCGTTGAC
CTTGTAGAACCTGAGTTATGACAAGCTTCCTGAAGTATTTTGGAAGATAGTACTTCCGGAAAGGACATTAGGAAAGACTAAACAGTGGAC

>In-frame_ENST00000367731_ENST00000333850_TCGA-DX-A3U6-01A_DNM3_chr1_172222822_+_TPH2_chr12_72388219_length(amino acids)=774AA_start in transcript=133_stop in transcript=2457
MVAGPSGKMGNREMEELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLVLQLVTSKAEYAE
FLHCKGKKFTDFDEVRLEIEAETDRVTGMNKGISSIPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIREMIMQFITRENCLIL
AVTPANTDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYVGVVNRSQKDIDGKKDIKAAMLAERKFFLSH
PAYRHIADRMGTPHLQKVLNQQLTNHIRDTLPNFRNKLQGQLLSIEHEVEAYKNFKPEDPTRKTKALLQMVQQFAVDFEKRIEGSGDQVD
TLELSGGAKINRIFHERFPFEIVKMEFNEKELRREISYAIKNIHGIRTGLFTPDMAFEAIVKKQIVKLKGPSLKSVDLVIQELINTVKKC
TKKLANFPRLCEETERIVANHIREREGKTKDQVLLLIDIQVSYINTNHEDFIGFANAQQRSSQVHKKTTVGNQVIRKGWLTISNIGIMKG
GSKGYWFVLTAESLSWYKDDEEKEKKYMLPLDNLKVRDVEKSFMSSKHIFALFNTEQRDTCHELLGHVPLLADPKFAQFSQEIGLASLGA
SDEDVQKLATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYFVSESFEEAKEKMRDFA

--------------------------------------------------------------
>In-frame_ENST00000520906_ENST00000333850_TCGA-DX-A3U6-01A_DNM3_chr1_172222822_+_TPH2_chr12_72388219_length(transcript)=3175nt_BP=1897nt
GACGTCTGCGCCAGGACCTGGCTGGCTGAGCCCGGCGCAGCAGCAGCAGCCAGGGCAGCGCGGCCCCTACTCCCTGTCAGGTCGTAGAGG
CGAGCAGGGACCAGCTGGTCGCCGGCCCCTCGGGCAAGATGGGGAACCGGGAGATGGAGGAGCTGATCCCGCTGGTGAACCGTCTGCAGG
ACGCGTTTTCGGCGCTGGGACAGAGCTGCCTGCTGGAGCTGCCGCAGATCGCCGTGGTGGGCGGCCAGAGCGCCGGCAAGAGCTCGGTGC
TCGAGAACTTCGTGGGCAGGGACTTTCTCCCTCGAGGGTCGGGCATTGTAACAAGACGACCTCTTGTGCTGCAGCTTGTTACTTCTAAAG
CAGAATATGCCGAGTTTCTACATTGCAAAGGAAAGAAATTTACAGATTTTGATGAAGTTCGCCTTGAGATTGAAGCAGAAACAGATCGCG
TGACTGGAATGAATAAAGGCATTTCCTCCATACCCATTAATTTACGAGTCTATTCCCCACACGTGTTAAATCTAACCCTTATTGATCTAC
CTGGAATAACTAAAGTGCCTGTGGGAGATCAGCCACCAGATATCGAGTATCAGATCAGAGAAATGATTATGCAGTTCATCACGAGGGAGA
ACTGTCTGATTTTAGCTGTTACTCCAGCCAACACTGATCTTGCAAACTCAGATGCGCTGAAGCTAGCTAAAGAAGTTGATCCTCAAGGTC
TGAGAACCATTGGAGTTATCACCAAACTGGACCTTATGGATGAAGGAACGGATGCCAGGGATGTTCTAGAGAACAAACTGTTGCCTCTTC
GCAGGGGTTACGTGGGGGTGGTAAACAGAAGCCAGAAGGACATAGATGGGAAGAAGGACATAAAGGCAGCCATGCTGGCAGAGAGGAAGT
TTTTCCTTTCCCACCCGGCTTACAGACATATCGCTGACCGAATGGGAACCCCACACCTGCAGAAGGTCCTTAATCAGCAACTTACCAACC
ACATTCGGGATACCCTACCAAACTTCAGGAACAAACTACAGGGACAGTTGCTCTCCATAGAACATGAAGTAGAAGCCTACAAAAATTTCA
AACCAGAAGACCCAACAAGGAAGACCAAAGCATTGCTGCAGATGGTTCAGCAATTTGCTGTGGACTTTGAGAAGAGAATTGAAGGGTCAG
GGGATCAAGTAGATACCCTGGAACTCTCAGGTGGTGCTAAAATCAATCGTATTTTTCATGAACGCTTTCCTTTTGAGATAGTAAAGATGG
AGTTCAATGAGAAAGAATTGCGAAGAGAAATAAGCTATGCAATCAAAAACATACATGGTATCAGGACAGGGTTGTTTACTCCAGACATGG
CATTTGAAGCGATAGTCAAGAAACAGATTGTAAAGTTGAAAGGGCCTTCCTTGAAGAGTGTGGATCTGGTAATACAAGAATTAATCAACA
CTGTGAAGAAGTGTACCAAAAAACTGGCAAACTTCCCCAGACTCTGCGAGGAAACGGAAAGGATTGTTGCTAACCACATTCGTGAGCGAG
AAGGGAAGACAAAGGACCAGGTATTGCTATTGATTGACATTCAAGTCTCTTACATCAACACCAACCATGAAGACTTCATTGGCTTCGCAA
ATGCTCAGCAGAGGAGCAGTCAGGTTCACAAGAAAACCACAGTTGGAAATCAGGTGATTCGCAAGGGGTGGCTCACCATCAGCAACATTG
GCATCATGAAAGGCGGCTCGAAGGGATACTGGTTCGTCCTTACTGCGGAAAGCTTGTCCTGGTATAAAGATGATGAGGAAAAAGAAAAGA
AGTACATGCTTCCCTTGGACAACCTGAAAGTTCGGGATGTGGAAAAGAGCTTTATGTCTAGCAAGCACATCTTTGCACTCTTTAATACAG
AGCAAAGAGACACATGCCATGAACTCTTGGGACATGTTCCACTACTTGCGGATCCTAAGTTTGCTCAGTTTTCACAAGAAATAGGTCTGG
CGTCTCTGGGAGCATCAGATGAAGATGTTCAGAAACTAGCCACGTGCTATTTCTTCACAATCGAGTTTGGCCTTTGCAAGCAAGAAGGGC
AACTGCGGGCATATGGAGCAGGACTCCTTTCCTCCATTGGAGAATTAAAGCACGCCCTTTCTGACAAGGCATGTGTGAAAGCCTTTGACC
CAAAGACAACTTGCTTACAGGAATGCCTTATCACCACCTTCCAGGAAGCCTACTTTGTTTCAGAAAGTTTTGAAGAAGCCAAAGAAAAGA
TGAGGGACTTTGCAAAGTCAATTACCCGTCCCTTCTCAGTATACTTCAATCCCTACACACAGAGTATTGAAATTCTGAAAGACACCAGAA
GTATTGAAAATGTGGTGCAGGACCTTCGCAGCGACTTGAATACAGTGTGTGATGCTTTAAACAAAATGAACCAATATCTGGGGATTTGAT
GCCTGGAACTATGTTGTTGCCAGCATGATCTTTTTGGGGCTTAGCAGCAGTTCAGTCAATGTCATATAACGCAAATAACCTTCTGTGTCA
TGGCTTGGCTAATAAGCATGCAATTCCATATATCTATACCATCTTGTAACTCACTGTGTTAGTATATAAAGCACCATAAGAAATCCAATG
GCAGATAACCACTCATTGTATGAAATAACGTATTATGTTTAAACATCTTAAAAAGATTTGACATTCCTGCTTAGTGTCCTTAACCAAACT
GCATCTAGTTAAAATTTGTAACAAATAGCCCTCTTATGAGTCTCATTTATGCCCTTTTCTTTTTCAGATCTAAGCCTTTCCTCTGTGTTC
ATTAGATAAAATGAAAAAAAGCAGTGAAGCTGTTTCCATTTTCAATAGTATCAGTGTTTTCACGCATTATTTGAGATAAACCCAGAATTG
TAGGAAACTTCCCATCACAATAACAAAGGTTCAATATTCTATTTCAAAAATTGTTGAGGTAACACAGCAGTTGGAATGATTTTTAGGTTG
AGTATTTACACAATGCAAGAAAACACCTTTTTACAAATGGAATTATGTAGGTTGCGTTGACCTTGTAGAACCTGAGTTATGACAAGCTTC
CTGAAGTATTTTGGAAGATAGTACTTCCGGAAAGGACATTAGGAAAGACTAAACAGTGGACAATCAATCTTGGGACTATGAATTTTATGC

>In-frame_ENST00000520906_ENST00000333850_TCGA-DX-A3U6-01A_DNM3_chr1_172222822_+_TPH2_chr12_72388219_length(amino acids)=774AA_start in transcript=104_stop in transcript=2428
MVAGPSGKMGNREMEELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLVLQLVTSKAEYAE
FLHCKGKKFTDFDEVRLEIEAETDRVTGMNKGISSIPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIREMIMQFITRENCLIL
AVTPANTDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYVGVVNRSQKDIDGKKDIKAAMLAERKFFLSH
PAYRHIADRMGTPHLQKVLNQQLTNHIRDTLPNFRNKLQGQLLSIEHEVEAYKNFKPEDPTRKTKALLQMVQQFAVDFEKRIEGSGDQVD
TLELSGGAKINRIFHERFPFEIVKMEFNEKELRREISYAIKNIHGIRTGLFTPDMAFEAIVKKQIVKLKGPSLKSVDLVIQELINTVKKC
TKKLANFPRLCEETERIVANHIREREGKTKDQVLLLIDIQVSYINTNHEDFIGFANAQQRSSQVHKKTTVGNQVIRKGWLTISNIGIMKG
GSKGYWFVLTAESLSWYKDDEEKEKKYMLPLDNLKVRDVEKSFMSSKHIFALFNTEQRDTCHELLGHVPLLADPKFAQFSQEIGLASLGA
SDEDVQKLATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYFVSESFEEAKEKMRDFA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for DNM3-TPH2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for DNM3-TPH2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for DNM3-TPH2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDNM3C0022665Kidney Neoplasm1CTD_human
HgeneDNM3C0740457Malignant neoplasm of kidney1CTD_human
TgeneTPH2C0011581Depressive disorder6CTD_human;PSYGENET
TgeneTPH2C0041696Unipolar Depression6CTD_human;PSYGENET
TgeneTPH2C0005586Bipolar Disorder5PSYGENET
TgeneTPH2C0011570Mental Depression5PSYGENET
TgeneTPH2C0525045Mood Disorders5PSYGENET
TgeneTPH2C1269683Major Depressive Disorder5CTD_human;PSYGENET
TgeneTPH2C0033975Psychotic Disorders2PSYGENET
TgeneTPH2C0036341Schizophrenia2PSYGENET
TgeneTPH2C0600427Cocaine Dependence2PSYGENET
TgeneTPH2C0004352Autistic Disorder1CTD_human
TgeneTPH2C0005587Depression, Bipolar1PSYGENET
TgeneTPH2C0011573Endogenous depression1CTD_human
TgeneTPH2C0015967Fever1CTD_human
TgeneTPH2C0025193Melancholia1CTD_human
TgeneTPH2C0036349Paranoid Schizophrenia1PSYGENET
TgeneTPH2C0085762Alcohol abuse1PSYGENET
TgeneTPH2C0086133Depressive Syndrome1CTD_human
TgeneTPH2C0282126Depression, Neurotic1CTD_human
TgeneTPH2C2751802ATTENTION DEFICIT-HYPERACTIVITY DISORDER, SUSCEPTIBILITY TO, 71UNIPROT