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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:DPP6-ACTR3B (FusionGDB2 ID:24004) |
Fusion Gene Summary for DPP6-ACTR3B |
Fusion gene summary |
Fusion gene information | Fusion gene name: DPP6-ACTR3B | Fusion gene ID: 24004 | Hgene | Tgene | Gene symbol | DPP6 | ACTR3B | Gene ID | 1804 | 57180 |
Gene name | dipeptidyl peptidase like 6 | actin related protein 3B | |
Synonyms | DPL1|DPPX|MRD33|VF2 | ARP11|ARP3BETA | |
Cytomap | 7q36.2 | 7q36.1-q36.2 | |
Type of gene | protein-coding | protein-coding | |
Description | dipeptidyl aminopeptidase-like protein 6DPP VIdipeptidyl aminopeptidase IV-related proteindipeptidyl peptidase IV-related proteindipeptidyl peptidase VIdipeptidyl-peptidase 6 | actin-related protein 3BARP3 actin related protein 3 homolog BARP3-betaactin-like protein 3Bactin-related protein 3-betaactin-related protein ARP4actin-related protein Arp11 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | Q9P1U1 | |
Ensembl transtripts involved in fusion gene | ENST00000404039, ENST00000406326, ENST00000377770, ENST00000332007, ENST00000496611, ENST00000427557, | ENST00000377776, ENST00000256001, ENST00000397282, ENST00000537264, ENST00000488782, | |
Fusion gene scores | * DoF score | 9 X 10 X 5=450 | 5 X 7 X 6=210 |
# samples | 12 | 8 | |
** MAII score | log2(12/450*10)=-1.90689059560852 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/210*10)=-1.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: DPP6 [Title/Abstract] AND ACTR3B [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | DPP6(153750148)-ACTR3B(152498705), # samples:24 | ||
Anticipated loss of major functional domain due to fusion event. | DPP6-ACTR3B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. DPP6-ACTR3B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. DPP6-ACTR3B seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | DPP6 | GO:1901379 | regulation of potassium ion transmembrane transport | 18364354 |
Fusion gene breakpoints across DPP6 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across ACTR3B (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | ESCA | TCGA-IG-A3YB | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
ChimerDB4 | ESCA | TCGA-IG-A3YB | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
ChimerDB4 | ESCA | TCGA-V5-AASV | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
ChimerDB4 | GBM | TCGA-06-0645 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
ChimerDB4 | GBM | TCGA-32-2638 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
ChimerDB4 | GBM | TCGA-27-2523 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
ChimerDB4 | GBM | TCGA-14-1823 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
ChimerDB4 | GBM | TCGA-02-2485 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
ChimerDB4 | GBM | TCGA-06-2558 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
ChimerDB4 | GBM | TCGA-06-5415 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
ChimerDB4 | GBM | TCGA-06-5412 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
ChimerDB4 | GBM | TCGA-28-2514 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
ChimerDB4 | GBM | TCGA-41-2572 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
ChimerDB4 | GBM | TCGA-15-0742 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
ChimerDB4 | GBM | TCGA-06-2562 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
ChimerDB4 | GBM | TCGA-28-1747 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
ChimerDB4 | GBM | TCGA-28-5204 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
ChimerDB4 | GBM | TCGA-06-0210 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
ChimerDB4 | GBM | TCGA-26-5134 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
ChimerDB4 | GBM | TCGA-06-5408 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
ChimerDB4 | GBM | TCGA-06-0125 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
ChimerDB4 | GBM | TCGA-14-0790 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
ChimerDB4 | GBM | TCGA-28-5207 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
ChimerDB4 | GBM | TCGA-28-5215 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
ChimerDB4 | GBM | TCGA-19-5960 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
ChimerDB4 | GBM | TCGA-19-1390 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
ChimerDB4 | GBM | TCGA-06-2567 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
ChimerDB4 | GBM | TCGA-12-3653 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
ChimerDB4 | GBM | TCGA-06-0190 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
ChimerDB4 | GBM | TCGA-06-5414 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
ChimerDB4 | GBM | TCGA-76-4928 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
ChimerDB4 | OV | TCGA-61-2110 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
ChimerDB4 | OV | TCGA-61-1995 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
ChimerDB4 | OV | TCGA-09-2045 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
ChimerDB4 | OV | TCGA-59-2363 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
ChimerDB4 | OV | TCGA-24-1419 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
ChimerDB4 | OV | TCGA-13-A5FT | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
ChimerDB4 | OV | TCGA-24-1567 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
ChimerDB4 | STAD | TCGA-VQ-A8E2 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
ChimerDB4 | GBM | TCGA-32-1982-01A | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
ChimerDB4 | GBM | TCGA-06-0184-01A | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
ChimerDB4 | GBM | TCGA-06-0190-02A | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
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Fusion Gene ORF analysis for DPP6-ACTR3B |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000404039 | ENST00000377776 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
intron-3CDS | ENST00000404039 | ENST00000256001 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
intron-5UTR | ENST00000404039 | ENST00000397282 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
intron-5UTR | ENST00000404039 | ENST00000537264 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
intron-3UTR | ENST00000404039 | ENST00000488782 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
In-frame | ENST00000406326 | ENST00000377776 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
In-frame | ENST00000406326 | ENST00000256001 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
5CDS-5UTR | ENST00000406326 | ENST00000397282 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
5CDS-5UTR | ENST00000406326 | ENST00000537264 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
5CDS-3UTR | ENST00000406326 | ENST00000488782 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
In-frame | ENST00000377770 | ENST00000377776 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
In-frame | ENST00000377770 | ENST00000256001 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
5CDS-5UTR | ENST00000377770 | ENST00000397282 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
5CDS-5UTR | ENST00000377770 | ENST00000537264 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
5CDS-3UTR | ENST00000377770 | ENST00000488782 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
intron-3CDS | ENST00000332007 | ENST00000377776 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
intron-3CDS | ENST00000332007 | ENST00000256001 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
intron-5UTR | ENST00000332007 | ENST00000397282 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
intron-5UTR | ENST00000332007 | ENST00000537264 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
intron-3UTR | ENST00000332007 | ENST00000488782 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
intron-3CDS | ENST00000496611 | ENST00000377776 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
intron-3CDS | ENST00000496611 | ENST00000256001 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
intron-5UTR | ENST00000496611 | ENST00000397282 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
intron-5UTR | ENST00000496611 | ENST00000537264 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
intron-3UTR | ENST00000496611 | ENST00000488782 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
intron-3CDS | ENST00000427557 | ENST00000377776 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
intron-3CDS | ENST00000427557 | ENST00000256001 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
intron-5UTR | ENST00000427557 | ENST00000397282 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
intron-5UTR | ENST00000427557 | ENST00000537264 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
intron-3UTR | ENST00000427557 | ENST00000488782 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + |
intron-3CDS | ENST00000404039 | ENST00000377776 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
intron-3CDS | ENST00000404039 | ENST00000256001 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
intron-intron | ENST00000404039 | ENST00000397282 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
intron-5UTR | ENST00000404039 | ENST00000537264 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
intron-intron | ENST00000404039 | ENST00000488782 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
Frame-shift | ENST00000406326 | ENST00000377776 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
Frame-shift | ENST00000406326 | ENST00000256001 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
5CDS-intron | ENST00000406326 | ENST00000397282 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
5CDS-5UTR | ENST00000406326 | ENST00000537264 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
5CDS-intron | ENST00000406326 | ENST00000488782 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
Frame-shift | ENST00000377770 | ENST00000377776 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
Frame-shift | ENST00000377770 | ENST00000256001 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
5CDS-intron | ENST00000377770 | ENST00000397282 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
5CDS-5UTR | ENST00000377770 | ENST00000537264 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
5CDS-intron | ENST00000377770 | ENST00000488782 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
intron-3CDS | ENST00000332007 | ENST00000377776 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
intron-3CDS | ENST00000332007 | ENST00000256001 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
intron-intron | ENST00000332007 | ENST00000397282 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
intron-5UTR | ENST00000332007 | ENST00000537264 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
intron-intron | ENST00000332007 | ENST00000488782 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
intron-3CDS | ENST00000496611 | ENST00000377776 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
intron-3CDS | ENST00000496611 | ENST00000256001 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
intron-intron | ENST00000496611 | ENST00000397282 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
intron-5UTR | ENST00000496611 | ENST00000537264 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
intron-intron | ENST00000496611 | ENST00000488782 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
intron-3CDS | ENST00000427557 | ENST00000377776 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
intron-3CDS | ENST00000427557 | ENST00000256001 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
intron-intron | ENST00000427557 | ENST00000397282 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
intron-5UTR | ENST00000427557 | ENST00000537264 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
intron-intron | ENST00000427557 | ENST00000488782 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + |
intron-3CDS | ENST00000404039 | ENST00000377776 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
intron-3CDS | ENST00000404039 | ENST00000256001 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
intron-intron | ENST00000404039 | ENST00000397282 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
intron-5UTR | ENST00000404039 | ENST00000537264 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
intron-intron | ENST00000404039 | ENST00000488782 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
Frame-shift | ENST00000406326 | ENST00000377776 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
Frame-shift | ENST00000406326 | ENST00000256001 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
5CDS-intron | ENST00000406326 | ENST00000397282 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
5CDS-5UTR | ENST00000406326 | ENST00000537264 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
5CDS-intron | ENST00000406326 | ENST00000488782 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
Frame-shift | ENST00000377770 | ENST00000377776 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
Frame-shift | ENST00000377770 | ENST00000256001 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
5CDS-intron | ENST00000377770 | ENST00000397282 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
5CDS-5UTR | ENST00000377770 | ENST00000537264 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
5CDS-intron | ENST00000377770 | ENST00000488782 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
intron-3CDS | ENST00000332007 | ENST00000377776 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
intron-3CDS | ENST00000332007 | ENST00000256001 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
intron-intron | ENST00000332007 | ENST00000397282 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
intron-5UTR | ENST00000332007 | ENST00000537264 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
intron-intron | ENST00000332007 | ENST00000488782 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
intron-3CDS | ENST00000496611 | ENST00000377776 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
intron-3CDS | ENST00000496611 | ENST00000256001 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
intron-intron | ENST00000496611 | ENST00000397282 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
intron-5UTR | ENST00000496611 | ENST00000537264 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
intron-intron | ENST00000496611 | ENST00000488782 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
intron-3CDS | ENST00000427557 | ENST00000377776 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
intron-3CDS | ENST00000427557 | ENST00000256001 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
intron-intron | ENST00000427557 | ENST00000397282 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
intron-5UTR | ENST00000427557 | ENST00000537264 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
intron-intron | ENST00000427557 | ENST00000488782 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480272 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000406326 | DPP6 | chr7 | 153750148 | + | ENST00000377776 | ACTR3B | chr7 | 152498705 | + | 1853 | 646 | 106 | 1467 | 453 |
ENST00000406326 | DPP6 | chr7 | 153750148 | + | ENST00000256001 | ACTR3B | chr7 | 152498705 | + | 2503 | 646 | 106 | 1677 | 523 |
ENST00000377770 | DPP6 | chr7 | 153750148 | + | ENST00000377776 | ACTR3B | chr7 | 152498705 | + | 1591 | 384 | 57 | 1205 | 382 |
ENST00000377770 | DPP6 | chr7 | 153750148 | + | ENST00000256001 | ACTR3B | chr7 | 152498705 | + | 2241 | 384 | 57 | 1415 | 452 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000406326 | ENST00000377776 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + | 0.001018145 | 0.9989818 |
ENST00000406326 | ENST00000256001 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + | 0.000401046 | 0.9995989 |
ENST00000377770 | ENST00000377776 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + | 0.000948191 | 0.99905175 |
ENST00000377770 | ENST00000256001 | DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + | 0.000370885 | 0.99962914 |
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Fusion Genomic Features for DPP6-ACTR3B |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + | 0.19898795 | 0.80101204 |
DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + | 0.19898795 | 0.80101204 |
DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + | 0.000200121 | 0.9997999 |
DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + | 0.000200121 | 0.9997999 |
DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + | 0.19898795 | 0.80101204 |
DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152480271 | + | 0.19898795 | 0.80101204 |
DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + | 0.000200121 | 0.9997999 |
DPP6 | chr7 | 153750148 | + | ACTR3B | chr7 | 152498705 | + | 0.000200121 | 0.9997999 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for DPP6-ACTR3B |
Go to FGviewer for the breakpoints of chr7:153750148-chr7:152498705 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | ACTR3B |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors. {ECO:0000269|PubMed:14651955}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | DPP6 | chr7:153750148 | chr7:152498705 | ENST00000332007 | + | 1 | 26 | 117_865 | 0 | 804.0 | Topological domain | Extracellular |
Hgene | DPP6 | chr7:153750148 | chr7:152498705 | ENST00000332007 | + | 1 | 26 | 1_95 | 0 | 804.0 | Topological domain | Cytoplasmic |
Hgene | DPP6 | chr7:153750148 | chr7:152498705 | ENST00000377770 | + | 1 | 26 | 117_865 | 81.0 | 866.0 | Topological domain | Extracellular |
Hgene | DPP6 | chr7:153750148 | chr7:152498705 | ENST00000377770 | + | 1 | 26 | 1_95 | 81.0 | 866.0 | Topological domain | Cytoplasmic |
Hgene | DPP6 | chr7:153750148 | chr7:152498705 | ENST00000332007 | + | 1 | 26 | 96_116 | 0 | 804.0 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
Hgene | DPP6 | chr7:153750148 | chr7:152498705 | ENST00000377770 | + | 1 | 26 | 96_116 | 81.0 | 866.0 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
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Fusion Gene Sequence for DPP6-ACTR3B |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000406326_ENST00000377776_TCGA-IG-A3YB_DPP6_chr7_153750148_+_ACTR3B_chr7_152498705_length(transcript)=1853nt_BP=646nt GGTGGTGCCAAATTCTGGGGCCTAGGCATTTCCCTCGCTTTATGTTTTTGGTTTTTTTTCTTCCTTCAATCTCTTTGATTAGGCCGTACG TGGCTGTGGCAAGGAGTTGGGGAAAAAAATTATAAAAACAGGAAAGAGAGAAAGCACAGCCAGAGCCCCGGCTTCGCGAGCCGCCGGGGA GGGGGCGGAGGAGGCTGAGCCAGGCAGAGTCGCCAGCGGAGACTCGCGAGTGGCGCGCGGGAGGAGCGGCCGCCGGCGCTGGGCTTGCCT TGCTGCTGCTGCTGCTGCTGCCTCCCCACCGCCTTTTTTTTTTTTTAATCTGGAGCGGGGTGGGGAGTGGGAACCGGAGAGAAAGCAAAA TATTAAAAAGCCCCAAAGACAGCCAGCAGGAGCGCGGTGCCCGATGGCTTCGCTGTACCAGAGGTTCACTGGCAAGATCAACACCTCGAG GTCCTTCCCCGCGCCCCCGGAGGCGAGTCACCTCCTGGGCGGCCAGGGGCCCGAGGAGGACGGCGGCGCAGGAGCCAAGCCCCTCGGCCC GCGGGCGCAGGCGGCGGCGCCCCGGGAGCGCGGCGGCGGCGGCGGCGGCGCGGGTGGCCGGCCCCGGTTCCAGTACCAGGCGCGGAGCGA TGGTGACGAGGAGGACTGGCCGATACGACATGGAATCATTGAAGACTGGGATCTTATGGAAAGGTTCATGGAGCAAGTGGTTTTTAAATA TCTTCGAGCTGAACCTGAGGACCATTATTTTTTAATGACAGAACCTCCACTCAATACACCAGAAAACAGAGAGTATCTTGCAGAAATTAT GTTTGAATCATTTAACGTACCAGGACTCTACATTGCAGTTCAGGCAGTGCTGGCCTTGGCGGCATCTTGGACATCTCGACAAGTGGGTGA ACGTACGTTAACGGGGATAGTCATTGACAGCGGAGATGGAGTCACCCATGTTATCCCAGTGGCAGAAGGTTATGTAATTGGAAGCTGCAT CAAACACATCCCGATTGCAGGTAGAGATATTACGTATTTCATTCAACAGCTGCTAAGGGAGAGGGAGGTGGGAATCCCTCCTGAGCAGTC ACTGGAGACCGCAAAAGCCATTAAGGAGAAATACTGTTACATTTGCCCCGATATAGTCAAGGAATTTGCCAAGTATGATGTGGATCCCCG GAAGTGGATCAAACAGTACACGGGTATCAATGCGATCAACCAGAAGAAGTTTGTTATAGACGTTGGTTACGAAAGATTCCTGGGACCTGA AATATTCTTTCACCCGGAGTTTGCCAACCCAGACTTTATGGAGTCCATCTCAGATGTTGTTGATGAAGTAATACAGAACTGCCCCATCGA TGTGCGGCGCCCGCTGTATAAGCCCGAGTTCTTTCAGGTCTGCCACACCAAGAAGGACTATGAAGAGTACGGGCCCAGCATCTGCCGCCA CAACCCCGTCTTTGGAGTCATGTCCTAGTGTCTGCCTGAACGCGTCGTTCGATGGTGTCACGTTGGGGAACAAGTGTCCTTCAGAACCCA GAGAAGGCCGCCGTTCTGTAAATAGCGACGTCGGTGTTGCTGCCCAGCAGCGTGCTTGCATTGCCGGTGCATGAGGCGCGGCGCGGGCCC TTCAGTAAAAGCCATTTATCCGTGTGCCGACCGCTGTCTGCCAGCCTCCTCCTTCTCCCGCCCTCCTCACCCTCGCTCTCCCTCCTCCTC CTCCTCCGAGCTGCTAGCTGACAAATACAATTCTGAAGGAATCCAAATGTGACTTTGAAAATTGTTAGAGAAAACAACATTAGAAAATGG >In-frame_ENST00000406326_ENST00000377776_TCGA-IG-A3YB_DPP6_chr7_153750148_+_ACTR3B_chr7_152498705_length(amino acids)=453AA_start in transcript=106_stop in transcript=1467 MGKKIIKTGKRESTARAPASRAAGEGAEEAEPGRVASGDSRVARGRSGRRRWACLAAAAAAASPPPFFFFNLERGGEWEPERKQNIKKPQ RQPAGARCPMASLYQRFTGKINTSRSFPAPPEASHLLGGQGPEEDGGAGAKPLGPRAQAAAPRERGGGGGGAGGRPRFQYQARSDGDEED WPIRHGIIEDWDLMERFMEQVVFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTG IVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICPDIVKEFAKYDVDPRKWIKQ YTGINAINQKKFVIDVGYERFLGPEIFFHPEFANPDFMESISDVVDEVIQNCPIDVRRPLYKPEFFQVCHTKKDYEEYGPSICRHNPVFG -------------------------------------------------------------- >In-frame_ENST00000406326_ENST00000256001_TCGA-IG-A3YB_DPP6_chr7_153750148_+_ACTR3B_chr7_152498705_length(transcript)=2503nt_BP=646nt GGTGGTGCCAAATTCTGGGGCCTAGGCATTTCCCTCGCTTTATGTTTTTGGTTTTTTTTCTTCCTTCAATCTCTTTGATTAGGCCGTACG TGGCTGTGGCAAGGAGTTGGGGAAAAAAATTATAAAAACAGGAAAGAGAGAAAGCACAGCCAGAGCCCCGGCTTCGCGAGCCGCCGGGGA GGGGGCGGAGGAGGCTGAGCCAGGCAGAGTCGCCAGCGGAGACTCGCGAGTGGCGCGCGGGAGGAGCGGCCGCCGGCGCTGGGCTTGCCT TGCTGCTGCTGCTGCTGCTGCCTCCCCACCGCCTTTTTTTTTTTTTAATCTGGAGCGGGGTGGGGAGTGGGAACCGGAGAGAAAGCAAAA TATTAAAAAGCCCCAAAGACAGCCAGCAGGAGCGCGGTGCCCGATGGCTTCGCTGTACCAGAGGTTCACTGGCAAGATCAACACCTCGAG GTCCTTCCCCGCGCCCCCGGAGGCGAGTCACCTCCTGGGCGGCCAGGGGCCCGAGGAGGACGGCGGCGCAGGAGCCAAGCCCCTCGGCCC GCGGGCGCAGGCGGCGGCGCCCCGGGAGCGCGGCGGCGGCGGCGGCGGCGCGGGTGGCCGGCCCCGGTTCCAGTACCAGGCGCGGAGCGA TGGTGACGAGGAGGACTGGCCGATACGACATGGAATCATTGAAGACTGGGATCTTATGGAAAGGTTCATGGAGCAAGTGGTTTTTAAATA TCTTCGAGCTGAACCTGAGGACCATTATTTTTTAATGACAGAACCTCCACTCAATACACCAGAAAACAGAGAGTATCTTGCAGAAATTAT GTTTGAATCATTTAACGTACCAGGACTCTACATTGCAGTTCAGGCAGTGCTGGCCTTGGCGGCATCTTGGACATCTCGACAAGTGGGTGA ACGTACGTTAACGGGGATAGTCATTGACAGCGGAGATGGAGTCACCCATGTTATCCCAGTGGCAGAAGGTTATGTAATTGGAAGCTGCAT CAAACACATCCCGATTGCAGGTAGAGATATTACGTATTTCATTCAACAGCTGCTAAGGGAGAGGGAGGTGGGAATCCCTCCTGAGCAGTC ACTGGAGACCGCAAAAGCCATTAAGGAGAAATACTGTTACATTTGCCCCGATATAGTCAAGGAATTTGCCAAGTATGATGTGGATCCCCG GAAGTGGATCAAACAGTACACGGGTATCAATGCGATCAACCAGAAGAAGTTTGTTATAGACGTTGGTTACGAAAGATTCCTGGGACCTGA AATATTCTTTCACCCGGAGTTTGCCAACCCAGACTTTATGGAGTCCATCTCAGATGTTGTTGATGAAGTAATACAGAACTGCCCCATCGA TGTGCGGCGCCCGCTGTATAAGAATGTCGTACTCTCAGGAGGCTCCACCATGTTCAGGGATTTCGGACGCCGACTGCAGAGGGATTTGAA GAGAGTGGTGGATGCTAGGCTGAGGCTCAGCGAGGAGCTCAGCGGCGGGAGGATCAAGCCGAAGCCTGTGGAGGTCCAGGTGGTCACGCA TCACATGCAGCGCTACGCCGTGTGGTTCGGAGGCTCCATGCTGGCCTCGACTCCCGAGTTCTTTCAGGTCTGCCACACCAAGAAGGACTA TGAAGAGTACGGGCCCAGCATCTGCCGCCACAACCCCGTCTTTGGAGTCATGTCCTAGTGTCTGCCTGAACGCGTCGTTCGATGGTGTCA CGTTGGGGAACAAGTGTCCTTCAGAACCCAGAGAAGGCCGCCGTTCTGTAAATAGCGACGTCGGTGTTGCTGCCCAGCAGCGTGCTTGCA TTGCCGGTGCATGAGGCGCGGCGCGGGCCCTTCAGTAAAAGCCATTTATCCGTGTGCCGACCGCTGTCTGCCAGCCTCCTCCTTCTCCCG CCCTCCTCACCCTCGCTCTCCCTCCTCCTCCTCCTCCGAGCTGCTAGCTGACAAATACAATTCTGAAGGAATCCAAATGTGACTTTGAAA ATTGTTAGAGAAAACAACATTAGAAAATGGCGCAAAATCGTTAGGTCCCAGGAGAGAATGTGGGGGCGCAAACCCTTTTCCTCCCAGCCT ATTTTTGTAAATAAAATGTTTAAACTTGAAATACAAATCGATGTTTATATTTCCTATCATTTTGTATTTTATGGTATTTGGTACAACTGG CTGATACTAAGCACGAATAGATATTGATGTTATGGAGTGCTGTAATCCAAAGTTTTTAATTGTGAGGCATGTTCTGATATGTTTATAGGC AAACAAATAAAACAGCAAACTTTTTTGCCACATGTTTGCTAGAAAATGATTATACTTTATTGGAGTGACATGAAGTTTGAACACTAAACA GTAATGTATGAGAATTACTACAGATACATGTATCTTTTAGTTTTTTTTGTTTGAACTTTCTGGAGCTGTTTTATAGAAGATGATGGTTTG >In-frame_ENST00000406326_ENST00000256001_TCGA-IG-A3YB_DPP6_chr7_153750148_+_ACTR3B_chr7_152498705_length(amino acids)=523AA_start in transcript=106_stop in transcript=1677 MGKKIIKTGKRESTARAPASRAAGEGAEEAEPGRVASGDSRVARGRSGRRRWACLAAAAAAASPPPFFFFNLERGGEWEPERKQNIKKPQ RQPAGARCPMASLYQRFTGKINTSRSFPAPPEASHLLGGQGPEEDGGAGAKPLGPRAQAAAPRERGGGGGGAGGRPRFQYQARSDGDEED WPIRHGIIEDWDLMERFMEQVVFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTG IVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICPDIVKEFAKYDVDPRKWIKQ YTGINAINQKKFVIDVGYERFLGPEIFFHPEFANPDFMESISDVVDEVIQNCPIDVRRPLYKNVVLSGGSTMFRDFGRRLQRDLKRVVDA -------------------------------------------------------------- >In-frame_ENST00000377770_ENST00000377776_TCGA-IG-A3YB_DPP6_chr7_153750148_+_ACTR3B_chr7_152498705_length(transcript)=1591nt_BP=384nt GCTTGCCTTGCTGCTGCTGCTGCTGCTGCCTCCCCACCGCCTTTTTTTTTTTTTAATCTGGAGCGGGGTGGGGAGTGGGAACCGGAGAGA AAGCAAAATATTAAAAAGCCCCAAAGACAGCCAGCAGGAGCGCGGTGCCCGATGGCTTCGCTGTACCAGAGGTTCACTGGCAAGATCAAC ACCTCGAGGTCCTTCCCCGCGCCCCCGGAGGCGAGTCACCTCCTGGGCGGCCAGGGGCCCGAGGAGGACGGCGGCGCAGGAGCCAAGCCC CTCGGCCCGCGGGCGCAGGCGGCGGCGCCCCGGGAGCGCGGCGGCGGCGGCGGCGGCGCGGGTGGCCGGCCCCGGTTCCAGTACCAGGCG CGGAGCGATGGTGACGAGGAGGACTGGCCGATACGACATGGAATCATTGAAGACTGGGATCTTATGGAAAGGTTCATGGAGCAAGTGGTT TTTAAATATCTTCGAGCTGAACCTGAGGACCATTATTTTTTAATGACAGAACCTCCACTCAATACACCAGAAAACAGAGAGTATCTTGCA GAAATTATGTTTGAATCATTTAACGTACCAGGACTCTACATTGCAGTTCAGGCAGTGCTGGCCTTGGCGGCATCTTGGACATCTCGACAA GTGGGTGAACGTACGTTAACGGGGATAGTCATTGACAGCGGAGATGGAGTCACCCATGTTATCCCAGTGGCAGAAGGTTATGTAATTGGA AGCTGCATCAAACACATCCCGATTGCAGGTAGAGATATTACGTATTTCATTCAACAGCTGCTAAGGGAGAGGGAGGTGGGAATCCCTCCT GAGCAGTCACTGGAGACCGCAAAAGCCATTAAGGAGAAATACTGTTACATTTGCCCCGATATAGTCAAGGAATTTGCCAAGTATGATGTG GATCCCCGGAAGTGGATCAAACAGTACACGGGTATCAATGCGATCAACCAGAAGAAGTTTGTTATAGACGTTGGTTACGAAAGATTCCTG GGACCTGAAATATTCTTTCACCCGGAGTTTGCCAACCCAGACTTTATGGAGTCCATCTCAGATGTTGTTGATGAAGTAATACAGAACTGC CCCATCGATGTGCGGCGCCCGCTGTATAAGCCCGAGTTCTTTCAGGTCTGCCACACCAAGAAGGACTATGAAGAGTACGGGCCCAGCATC TGCCGCCACAACCCCGTCTTTGGAGTCATGTCCTAGTGTCTGCCTGAACGCGTCGTTCGATGGTGTCACGTTGGGGAACAAGTGTCCTTC AGAACCCAGAGAAGGCCGCCGTTCTGTAAATAGCGACGTCGGTGTTGCTGCCCAGCAGCGTGCTTGCATTGCCGGTGCATGAGGCGCGGC GCGGGCCCTTCAGTAAAAGCCATTTATCCGTGTGCCGACCGCTGTCTGCCAGCCTCCTCCTTCTCCCGCCCTCCTCACCCTCGCTCTCCC TCCTCCTCCTCCTCCGAGCTGCTAGCTGACAAATACAATTCTGAAGGAATCCAAATGTGACTTTGAAAATTGTTAGAGAAAACAACATTA >In-frame_ENST00000377770_ENST00000377776_TCGA-IG-A3YB_DPP6_chr7_153750148_+_ACTR3B_chr7_152498705_length(amino acids)=382AA_start in transcript=57_stop in transcript=1205 MERGGEWEPERKQNIKKPQRQPAGARCPMASLYQRFTGKINTSRSFPAPPEASHLLGGQGPEEDGGAGAKPLGPRAQAAAPRERGGGGGG AGGRPRFQYQARSDGDEEDWPIRHGIIEDWDLMERFMEQVVFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAV LALAASWTSRQVGERTLTGIVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICP DIVKEFAKYDVDPRKWIKQYTGINAINQKKFVIDVGYERFLGPEIFFHPEFANPDFMESISDVVDEVIQNCPIDVRRPLYKPEFFQVCHT -------------------------------------------------------------- >In-frame_ENST00000377770_ENST00000256001_TCGA-IG-A3YB_DPP6_chr7_153750148_+_ACTR3B_chr7_152498705_length(transcript)=2241nt_BP=384nt GCTTGCCTTGCTGCTGCTGCTGCTGCTGCCTCCCCACCGCCTTTTTTTTTTTTTAATCTGGAGCGGGGTGGGGAGTGGGAACCGGAGAGA AAGCAAAATATTAAAAAGCCCCAAAGACAGCCAGCAGGAGCGCGGTGCCCGATGGCTTCGCTGTACCAGAGGTTCACTGGCAAGATCAAC ACCTCGAGGTCCTTCCCCGCGCCCCCGGAGGCGAGTCACCTCCTGGGCGGCCAGGGGCCCGAGGAGGACGGCGGCGCAGGAGCCAAGCCC CTCGGCCCGCGGGCGCAGGCGGCGGCGCCCCGGGAGCGCGGCGGCGGCGGCGGCGGCGCGGGTGGCCGGCCCCGGTTCCAGTACCAGGCG CGGAGCGATGGTGACGAGGAGGACTGGCCGATACGACATGGAATCATTGAAGACTGGGATCTTATGGAAAGGTTCATGGAGCAAGTGGTT TTTAAATATCTTCGAGCTGAACCTGAGGACCATTATTTTTTAATGACAGAACCTCCACTCAATACACCAGAAAACAGAGAGTATCTTGCA GAAATTATGTTTGAATCATTTAACGTACCAGGACTCTACATTGCAGTTCAGGCAGTGCTGGCCTTGGCGGCATCTTGGACATCTCGACAA GTGGGTGAACGTACGTTAACGGGGATAGTCATTGACAGCGGAGATGGAGTCACCCATGTTATCCCAGTGGCAGAAGGTTATGTAATTGGA AGCTGCATCAAACACATCCCGATTGCAGGTAGAGATATTACGTATTTCATTCAACAGCTGCTAAGGGAGAGGGAGGTGGGAATCCCTCCT GAGCAGTCACTGGAGACCGCAAAAGCCATTAAGGAGAAATACTGTTACATTTGCCCCGATATAGTCAAGGAATTTGCCAAGTATGATGTG GATCCCCGGAAGTGGATCAAACAGTACACGGGTATCAATGCGATCAACCAGAAGAAGTTTGTTATAGACGTTGGTTACGAAAGATTCCTG GGACCTGAAATATTCTTTCACCCGGAGTTTGCCAACCCAGACTTTATGGAGTCCATCTCAGATGTTGTTGATGAAGTAATACAGAACTGC CCCATCGATGTGCGGCGCCCGCTGTATAAGAATGTCGTACTCTCAGGAGGCTCCACCATGTTCAGGGATTTCGGACGCCGACTGCAGAGG GATTTGAAGAGAGTGGTGGATGCTAGGCTGAGGCTCAGCGAGGAGCTCAGCGGCGGGAGGATCAAGCCGAAGCCTGTGGAGGTCCAGGTG GTCACGCATCACATGCAGCGCTACGCCGTGTGGTTCGGAGGCTCCATGCTGGCCTCGACTCCCGAGTTCTTTCAGGTCTGCCACACCAAG AAGGACTATGAAGAGTACGGGCCCAGCATCTGCCGCCACAACCCCGTCTTTGGAGTCATGTCCTAGTGTCTGCCTGAACGCGTCGTTCGA TGGTGTCACGTTGGGGAACAAGTGTCCTTCAGAACCCAGAGAAGGCCGCCGTTCTGTAAATAGCGACGTCGGTGTTGCTGCCCAGCAGCG TGCTTGCATTGCCGGTGCATGAGGCGCGGCGCGGGCCCTTCAGTAAAAGCCATTTATCCGTGTGCCGACCGCTGTCTGCCAGCCTCCTCC TTCTCCCGCCCTCCTCACCCTCGCTCTCCCTCCTCCTCCTCCTCCGAGCTGCTAGCTGACAAATACAATTCTGAAGGAATCCAAATGTGA CTTTGAAAATTGTTAGAGAAAACAACATTAGAAAATGGCGCAAAATCGTTAGGTCCCAGGAGAGAATGTGGGGGCGCAAACCCTTTTCCT CCCAGCCTATTTTTGTAAATAAAATGTTTAAACTTGAAATACAAATCGATGTTTATATTTCCTATCATTTTGTATTTTATGGTATTTGGT ACAACTGGCTGATACTAAGCACGAATAGATATTGATGTTATGGAGTGCTGTAATCCAAAGTTTTTAATTGTGAGGCATGTTCTGATATGT TTATAGGCAAACAAATAAAACAGCAAACTTTTTTGCCACATGTTTGCTAGAAAATGATTATACTTTATTGGAGTGACATGAAGTTTGAAC ACTAAACAGTAATGTATGAGAATTACTACAGATACATGTATCTTTTAGTTTTTTTTGTTTGAACTTTCTGGAGCTGTTTTATAGAAGATG >In-frame_ENST00000377770_ENST00000256001_TCGA-IG-A3YB_DPP6_chr7_153750148_+_ACTR3B_chr7_152498705_length(amino acids)=452AA_start in transcript=57_stop in transcript=1415 MERGGEWEPERKQNIKKPQRQPAGARCPMASLYQRFTGKINTSRSFPAPPEASHLLGGQGPEEDGGAGAKPLGPRAQAAAPRERGGGGGG AGGRPRFQYQARSDGDEEDWPIRHGIIEDWDLMERFMEQVVFKYLRAEPEDHYFLMTEPPLNTPENREYLAEIMFESFNVPGLYIAVQAV LALAASWTSRQVGERTLTGIVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLREREVGIPPEQSLETAKAIKEKYCYICP DIVKEFAKYDVDPRKWIKQYTGINAINQKKFVIDVGYERFLGPEIFFHPEFANPDFMESISDVVDEVIQNCPIDVRRPLYKNVVLSGGST MFRDFGRRLQRDLKRVVDARLRLSEELSGGRIKPKPVEVQVVTHHMQRYAVWFGGSMLASTPEFFQVCHTKKDYEEYGPSICRHNPVFGV -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for DPP6-ACTR3B |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for DPP6-ACTR3B |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for DPP6-ACTR3B |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | DPP6 | C1510586 | Autism Spectrum Disorders | 2 | CTD_human |
Hgene | DPP6 | C2751898 | Ventricular Fibrillation, Paroxysmal Familial, 1 | 2 | ORPHANET |
Hgene | DPP6 | C4017668 | VENTRICULAR FIBRILLATION DURING MYOCARDIAL INFARCTION, SUSCEPTIBILITY TO | 2 | ORPHANET |
Hgene | DPP6 | C0002736 | Amyotrophic Lateral Sclerosis | 1 | CTD_human |
Hgene | DPP6 | C0220693 | Microcephaly autosomal dominant | 1 | ORPHANET |
Hgene | DPP6 | C0393554 | Amyotrophic Lateral Sclerosis With Dementia | 1 | CTD_human |
Hgene | DPP6 | C0431350 | Primary microcephaly | 1 | GENOMICS_ENGLAND |
Hgene | DPP6 | C0543859 | Amyotrophic Lateral Sclerosis, Guam Form | 1 | CTD_human |
Hgene | DPP6 | C4225375 | MENTAL RETARDATION, AUTOSOMAL DOMINANT 33 | 1 | CTD_human;GENOMICS_ENGLAND;UNIPROT |