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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:DPP6-IFIT3 (FusionGDB2 ID:24010)

Fusion Gene Summary for DPP6-IFIT3

Fusion gene summary

Fusion gene information	Fusion gene name: DPP6-IFIT3
	Fusion gene ID: 24010
		Hgene	Tgene
	Gene symbol	DPP6	IFIT3
	Gene ID	1804	3437
	Gene name	dipeptidyl peptidase like 6	interferon induced protein with tetratricopeptide repeats 3
	Synonyms	DPL1\|DPPX\|MRD33\|VF2	CIG-49\|GARG-49\|IFI60\|IFIT4\|IRG2\|ISG60\|P60\|RIG-G\|cig41
	Cytomap	7q36.2	10q23.31
	Type of gene	protein-coding	protein-coding
	Description	dipeptidyl aminopeptidase-like protein 6DPP VIdipeptidyl aminopeptidase IV-related proteindipeptidyl peptidase IV-related proteindipeptidyl peptidase VIdipeptidyl-peptidase 6	interferon-induced protein with tetratricopeptide repeats 3CIG49IFI-60KIFIT-3IFIT-4ISG-60interferon-induced 60 kDa proteininterferon-induced protein with tetratricopeptide repeats 4retinoic acid-induced gene G protein
	Modification date	20200313	20200313
	UniProtAcc	.	O14879
	Ensembl transtripts involved in fusion gene	ENST00000404039, ENST00000406326, ENST00000377770, ENST00000332007, ENST00000496611, ENST00000427557,	ENST00000371818, ENST00000371811,
Fusion gene scores	* DoF score	9 X 10 X 5=450	2 X 2 X 2=8
	# samples	12	2
	** MAII score	log2(12/450*10)=-1.90689059560852 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: DPP6 [Title/Abstract] AND IFIT3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	DPP6(154461151)-IFIT3(91098418), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DPP6	GO:1901379	regulation of potassium ion transmembrane transport	18364354
Tgene	IFIT3	GO:0008285	negative regulation of cell proliferation	17050680
Tgene	IFIT3	GO:0043066	negative regulation of apoptotic process	21190939

Fusion gene breakpoints across DPP6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across IFIT3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PCPG	TCGA-QR-A70V-01A	DPP6	chr7	154461151	-	IFIT3	chr10	91098418	+

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Fusion Gene ORF analysis for DPP6-IFIT3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000404039	ENST00000371818	DPP6	chr7	154461151	-	IFIT3	chr10	91098418	+
In-frame	ENST00000404039	ENST00000371811	DPP6	chr7	154461151	-	IFIT3	chr10	91098418	+
intron-3CDS	ENST00000406326	ENST00000371818	DPP6	chr7	154461151	-	IFIT3	chr10	91098418	+
intron-3CDS	ENST00000406326	ENST00000371811	DPP6	chr7	154461151	-	IFIT3	chr10	91098418	+
In-frame	ENST00000377770	ENST00000371818	DPP6	chr7	154461151	-	IFIT3	chr10	91098418	+
In-frame	ENST00000377770	ENST00000371811	DPP6	chr7	154461151	-	IFIT3	chr10	91098418	+
In-frame	ENST00000332007	ENST00000371818	DPP6	chr7	154461151	-	IFIT3	chr10	91098418	+
In-frame	ENST00000332007	ENST00000371811	DPP6	chr7	154461151	-	IFIT3	chr10	91098418	+
intron-3CDS	ENST00000496611	ENST00000371818	DPP6	chr7	154461151	-	IFIT3	chr10	91098418	+
intron-3CDS	ENST00000496611	ENST00000371811	DPP6	chr7	154461151	-	IFIT3	chr10	91098418	+
intron-3CDS	ENST00000427557	ENST00000371818	DPP6	chr7	154461151	-	IFIT3	chr10	91098418	+
intron-3CDS	ENST00000427557	ENST00000371811	DPP6	chr7	154461151	-	IFIT3	chr10	91098418	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000404039	DPP6	chr7	154461151	-	ENST00000371818	IFIT3	chr10	91098418	+	3468	1157	1071	2624	517
ENST00000404039	DPP6	chr7	154461151	-	ENST00000371811	IFIT3	chr10	91098418	+	3468	1157	1071	2624	517
ENST00000377770	DPP6	chr7	154461151	-	ENST00000371818	IFIT3	chr10	91098418	+	3214	903	817	2370	517
ENST00000377770	DPP6	chr7	154461151	-	ENST00000371811	IFIT3	chr10	91098418	+	3214	903	817	2370	517
ENST00000332007	DPP6	chr7	154461151	-	ENST00000371818	IFIT3	chr10	91098418	+	3272	961	875	2428	517
ENST00000332007	DPP6	chr7	154461151	-	ENST00000371811	IFIT3	chr10	91098418	+	3272	961	875	2428	517

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000404039	ENST00000371818	DPP6	chr7	154461151	-	IFIT3	chr10	91098418	+	0.00197496	0.99802506
ENST00000404039	ENST00000371811	DPP6	chr7	154461151	-	IFIT3	chr10	91098418	+	0.00197496	0.99802506
ENST00000377770	ENST00000371818	DPP6	chr7	154461151	-	IFIT3	chr10	91098418	+	0.002296939	0.99770314
ENST00000377770	ENST00000371811	DPP6	chr7	154461151	-	IFIT3	chr10	91098418	+	0.002296939	0.99770314
ENST00000332007	ENST00000371818	DPP6	chr7	154461151	-	IFIT3	chr10	91098418	+	0.002458472	0.99754155
ENST00000332007	ENST00000371811	DPP6	chr7	154461151	-	IFIT3	chr10	91098418	+	0.002458472	0.99754155

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Fusion Genomic Features for DPP6-IFIT3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DPP6-IFIT3

Go to
FGviewer for the breakpoints of chr7:154461151-chr10:91098418
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	IFIT3 O14879
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2. {ECO:0000269\|PubMed:17050680, ECO:0000269\|PubMed:20686046, ECO:0000269\|PubMed:21190939, ECO:0000269\|PubMed:21642987, ECO:0000269\|PubMed:21813773}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DPP6

chr7:154461151

chr10:91098418

ENST00000332007

1_95

192.0

804.0

Topological domain

Cytoplasmic

Hgene

DPP6

chr7:154461151

chr10:91098418

ENST00000377770

1_95

254.0

866.0

Topological domain

Cytoplasmic

Hgene

DPP6

chr7:154461151

chr10:91098418

ENST00000332007

96_116

192.0

804.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

DPP6

chr7:154461151

chr10:91098418

ENST00000377770

96_116

254.0

866.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

IFIT3

chr7:154461151

chr10:91098418

ENST00000371811

136_169

1.6666666666666667

491.0

Repeat

Note=TPR 3

Tgene

IFIT3

chr7:154461151

chr10:91098418

ENST00000371811

172_206

1.6666666666666667

491.0

Repeat

Note=TPR 4

Tgene

IFIT3

chr7:154461151

chr10:91098418

ENST00000371811

207_240

1.6666666666666667

491.0

Repeat

Note=TPR 5

Tgene

IFIT3

chr7:154461151

chr10:91098418

ENST00000371811

241_274

1.6666666666666667

491.0

Repeat

Note=TPR 6

Tgene

IFIT3

chr7:154461151

chr10:91098418

ENST00000371811

415_448

1.6666666666666667

491.0

Repeat

Note=TPR 7

Tgene

IFIT3

chr7:154461151

chr10:91098418

ENST00000371811

450_481

1.6666666666666667

491.0

Repeat

Note=TPR 8

Tgene

IFIT3

chr7:154461151

chr10:91098418

ENST00000371811

51_84

1.6666666666666667

491.0

Repeat

Note=TPR 1

Tgene

IFIT3

chr7:154461151

chr10:91098418

ENST00000371811

94_127

1.6666666666666667

491.0

Repeat

Note=TPR 2

Tgene

IFIT3

chr7:154461151

chr10:91098418

ENST00000371818

136_169

1.6666666666666667

491.0

Repeat

Note=TPR 3

Tgene

IFIT3

chr7:154461151

chr10:91098418

ENST00000371818

172_206

1.6666666666666667

491.0

Repeat

Note=TPR 4

Tgene

IFIT3

chr7:154461151

chr10:91098418

ENST00000371818

207_240

1.6666666666666667

491.0

Repeat

Note=TPR 5

Tgene

IFIT3

chr7:154461151

chr10:91098418

ENST00000371818

241_274

1.6666666666666667

491.0

Repeat

Note=TPR 6

Tgene

IFIT3

chr7:154461151

chr10:91098418

ENST00000371818

415_448

1.6666666666666667

491.0

Repeat

Note=TPR 7

Tgene

IFIT3

chr7:154461151

chr10:91098418

ENST00000371818

450_481

1.6666666666666667

491.0

Repeat

Note=TPR 8

Tgene

IFIT3

chr7:154461151

chr10:91098418

ENST00000371818

51_84

1.6666666666666667

491.0

Repeat

Note=TPR 1

Tgene

IFIT3

chr7:154461151

chr10:91098418

ENST00000371818

94_127

1.6666666666666667

491.0

Repeat

Note=TPR 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DPP6

chr7:154461151

chr10:91098418

ENST00000332007

117_865

192.0

804.0

Topological domain

Extracellular

Hgene

DPP6

chr7:154461151

chr10:91098418

ENST00000377770

117_865

254.0

866.0

Topological domain

Extracellular

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Fusion Gene Sequence for DPP6-IFIT3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000404039_ENST00000371818_TCGA-QR-A70V-01A_DPP6_chr7_154461151_-_IFIT3_chr10_91098418_length(transcript)=3468nt_BP=1157nt
AGTTCAGACAGAAAACCTGGCGCGCGCGCGCGCACACACACACGCCTCCCCTGGCGTCGCCGCCCGGCCGGGTCCCTGCCCTTAGGGACC
AGAGCGGCGACCGCTGCACCCCGCACCGCCTGCTGGAGGAGCCCCCGGAGCCGGGGCCGAGCCGCCGGCGTCCCCGAGTGCGCCCCCTGT
GCGTGCCGCCGCGCTGTTGCTCGCAGTGTGCTGGCGCCGAGCTCGGTGGACACGCGCGCAGTCAGAGCTGCCTCTCGCCCTCGCTAGCTG
GGCTCGCAGCCTCTTCCTCCCTCCCTGGCTCCTGGCTTTTTGTTTAAAGCAACACCCACCCTCCATCCAGGCTTTTTTTCTTTCTTTCTT
TATTGGTAGCGGCCAAAAAGAGTTGATTGCTATTGGGATCCGCTGAGTAAAGACACGGGCAGGGGTGCGCGGAGGTGAGAAAACTGAAGA
CCTGGAAGATTTTTTTTTCCTTCAAAAACCCGTTTCCATCCAGTCTTCAGCCAGTCCAGTCTACTTTAATCCTCACCAGGACAATGGATT
AAGTTTCTCTTCCCTGGACCAGAAGTCGGGTTCGGACTTGGGGCAAAATGAAGGAAAAGGCCATGATCAAGACCGCTAAGATGCAGGGGA
ACGTGATGGAGCTGGTGGGGAGTAACCCTCCGCAGAGGAATTGGAAAGGAATAGCAATTGCACTGCTTGTCATTCTGGTCATCTGCTCCT
TGATCGTCACCTCGGTCATACTTCTGACACCAGCGGAAGATAATAGTCTGTCTCAAAAGAAGAAGGTCACTGTAGAAGATCTCTTCAGTG
AAGACTTCAAAATTCATGACCCCGAGGCTAAGTGGATAAGTGATACAGAATTCATCTACAGAGAACAGAAAGGAACAGTGAGACTGTGGA
ATGTTGAAACAAATACTTCTACTGTCTTAATAGAAGGCAAAAAAATTGAATCATTAAGAGCCATCAGATATGAAATATCTCCAGATAGAG
AGTATGCACTTTTTTCATACAATGTGGAACCCATATATCAACACTCGTATACTGGATATTACGTCCTGAGCAAAATTCCTCATGGGGATC
CTCAAAGTCTGGACCCACCAGAAGTCAGCAATGCAAAACTTCAGTATGCAGGATGGGGCCCTAAAGGCCAACAGCTGTGAGGTCACCAAG
AATTCCCTGGAGAAAATCCTTCCACAGCTGAAATGCCATTTCACCTGGAACTTATTCAAGGAAGACAGTGTCTCAAGGGATCTAGAAGAT
AGAGTGTGTAACCAGATTGAATTTTTAAACACTGAGTTCAAAGCTACAATGTACAACTTGTTGGCCTACATAAAACACCTAGATGGTAAC
AACGAGGCAGCCCTGGAATGCTTACGGCAAGCTGAAGAGTTAATCCAGCAAGAACATGCTGACCAAGCAGAAATCAGAAGTCTAGTCACT
TGGGGAAACTACGCCTGGGTCTACTATCACTTGGGCAGACTCTCAGATGCTCAGATTTATGTAGATAAGGTGAAACAAACCTGCAAGAAA
TTTTCAAATCCATACAGTATTGAGTATTCTGAACTTGACTGTGAGGAAGGGTGGACACAACTGAAGTGTGGAAGAAATGAAAGGGCGAAG
GTGTGTTTTGAGAAGGCTCTGGAAGAAAAGCCCAACAACCCAGAATTCTCCTCTGGACTGGCAATTGCGATGTACCATCTGGATAATCAC
CCAGAGAAACAGTTCTCTACTGATGTTTTGAAGCAGGCCATTGAGCTGAGTCCTGATAACCAATACGTCAAGGTTCTCTTGGGCCTGAAA
CTGCAGAAGATGAATAAAGAAGCTGAAGGAGAGCAGTTTGTTGAAGAAGCCTTGGAAAAGTCTCCTTGCCAAACAGATGTCCTCCGCAGT
GCAGCCAAATTTTACAGAAGAAAAGGTGACCTAGACAAAGCTATTGAACTGTTTCAACGGGTGTTGGAATCCACACCAAACAATGGCTAC
CTCTATCACCAGATTGGGTGCTGCTACAAGGCAAAAGTAAGACAAATGCAGAATACAGGAGAATCTGAAGCTAGTGGAAATAAAGAGATG
ATTGAAGCACTAAAGCAATATGCTATGGACTATTCGAATAAAGCTCTTGAGAAGGGACTGAATCCTCTGAATGCATACTCCGATCTCGCT
GAGTTCCTGGAGACGGAATGTTATCAGACACCATTCAATAAGGAAGTCCCTGATGCTGAAAAGCAACAATCCCATCAGCGCTACTGCAAC
CTTCAGAAATATAATGGGAAGTCTGAAGACACTGCTGTGCAACATGGTTTAGAGGGTTTGTCCATAAGCAAAAAATCAACTGACAAGGAA
GAGATCAAAGACCAACCACAGAATGTATCTGAAAATCTGCTTCCACAAAATGCACCAAATTATTGGTATCTTCAAGGATTAATTCATAAG
CAGAATGGAGATCTGCTGCAAGCAGCCAAATGTTATGAGAAGGAACTGGGCCGCCTGCTAAGGGATGCCCCTTCAGGCATAGGCAGTATT
TTCCTGTCAGCATCTGAGCTTGAGGATGGTAGTGAGGAAATGGGCCAGGGCGCAGTCAGCTCCAGTCCCAGAGAGCTCCTCTCTAACTCA
GAGCAACTGAACTGAGACAGAGGAGGAAAACAGAGCATCAGAAGCCTGCAGTGGTGGTTGTGACGGGTAGGACGATAGGAAGACAGGGGG
CCCCAACCTGGGATTGCTGAGCAGGGAAGCTTTGCATGTTGCTCTAAGGTACATTTTTAAAGAGTTGTTTTTTGGCCGGGCGCAGTGGCT
CATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACGAGGTCTGGAGTTTGAGACCATCCTGGCTAACACAGTGAAATC
CCGTCTCTACTAAAAATACAAAAAATTAGCCAGGCGTGGTGGCTGGCACCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGG
CGTGAACCTGGAAGGAAGAGGTTGCAGTGAGCCAAGATTGCGCCCCTGCACTCCAGCCTGGGCAACAGAGCAAGACTCCATCTCAAAAAA
AAAAAAAAAAAAAAAAAAGAGTTGTTTTCTCATGTTCATTATAGTTCATTACAGTTACATAGTCCGAAGGTCTTACAACTAATCACTGGT
AGCAATAAATGCTTCAGGCCCACATGATGCTGATTAGTTCTCAGTTTTCATTCAGTTCACAATATAACCACCATTCCTGCCCTCCCTGCC
AAGGGTCATAAATGGTGACTGCCTAACAACAAAATTTGCAGTCTCATCTCATTTTCATCCAGACTTCTGGAACTCAAAGATTAACTTTTG
ACTAACCCTGGAATATCTCTTATCTCACTTATAGCTTCAGGCATGTATTTATATGTATTCTTGATAGCAATACCATAATCAATGTGTATT

>In-frame_ENST00000404039_ENST00000371818_TCGA-QR-A70V-01A_DPP6_chr7_154461151_-_IFIT3_chr10_91098418_length(amino acids)=517AA_start in transcript=1071_stop in transcript=2624
MGILKVWTHQKSAMQNFSMQDGALKANSCEVTKNSLEKILPQLKCHFTWNLFKEDSVSRDLEDRVCNQIEFLNTEFKATMYNLLAYIKHL
DGNNEAALECLRQAEELIQQEHADQAEIRSLVTWGNYAWVYYHLGRLSDAQIYVDKVKQTCKKFSNPYSIEYSELDCEEGWTQLKCGRNE
RAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPEKQFSTDVLKQAIELSPDNQYVKVLLGLKLQKMNKEAEGEQFVEEALEKSPCQTDV
LRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYLYHQIGCCYKAKVRQMQNTGESEASGNKEMIEALKQYAMDYSNKALEKGLNPLNAYS
DLAEFLETECYQTPFNKEVPDAEKQQSHQRYCNLQKYNGKSEDTAVQHGLEGLSISKKSTDKEEIKDQPQNVSENLLPQNAPNYWYLQGL

--------------------------------------------------------------
>In-frame_ENST00000404039_ENST00000371811_TCGA-QR-A70V-01A_DPP6_chr7_154461151_-_IFIT3_chr10_91098418_length(transcript)=3468nt_BP=1157nt
AGTTCAGACAGAAAACCTGGCGCGCGCGCGCGCACACACACACGCCTCCCCTGGCGTCGCCGCCCGGCCGGGTCCCTGCCCTTAGGGACC
AGAGCGGCGACCGCTGCACCCCGCACCGCCTGCTGGAGGAGCCCCCGGAGCCGGGGCCGAGCCGCCGGCGTCCCCGAGTGCGCCCCCTGT
GCGTGCCGCCGCGCTGTTGCTCGCAGTGTGCTGGCGCCGAGCTCGGTGGACACGCGCGCAGTCAGAGCTGCCTCTCGCCCTCGCTAGCTG
GGCTCGCAGCCTCTTCCTCCCTCCCTGGCTCCTGGCTTTTTGTTTAAAGCAACACCCACCCTCCATCCAGGCTTTTTTTCTTTCTTTCTT
TATTGGTAGCGGCCAAAAAGAGTTGATTGCTATTGGGATCCGCTGAGTAAAGACACGGGCAGGGGTGCGCGGAGGTGAGAAAACTGAAGA
CCTGGAAGATTTTTTTTTCCTTCAAAAACCCGTTTCCATCCAGTCTTCAGCCAGTCCAGTCTACTTTAATCCTCACCAGGACAATGGATT
AAGTTTCTCTTCCCTGGACCAGAAGTCGGGTTCGGACTTGGGGCAAAATGAAGGAAAAGGCCATGATCAAGACCGCTAAGATGCAGGGGA
ACGTGATGGAGCTGGTGGGGAGTAACCCTCCGCAGAGGAATTGGAAAGGAATAGCAATTGCACTGCTTGTCATTCTGGTCATCTGCTCCT
TGATCGTCACCTCGGTCATACTTCTGACACCAGCGGAAGATAATAGTCTGTCTCAAAAGAAGAAGGTCACTGTAGAAGATCTCTTCAGTG
AAGACTTCAAAATTCATGACCCCGAGGCTAAGTGGATAAGTGATACAGAATTCATCTACAGAGAACAGAAAGGAACAGTGAGACTGTGGA
ATGTTGAAACAAATACTTCTACTGTCTTAATAGAAGGCAAAAAAATTGAATCATTAAGAGCCATCAGATATGAAATATCTCCAGATAGAG
AGTATGCACTTTTTTCATACAATGTGGAACCCATATATCAACACTCGTATACTGGATATTACGTCCTGAGCAAAATTCCTCATGGGGATC
CTCAAAGTCTGGACCCACCAGAAGTCAGCAATGCAAAACTTCAGTATGCAGGATGGGGCCCTAAAGGCCAACAGCTGTGAGGTCACCAAG
AATTCCCTGGAGAAAATCCTTCCACAGCTGAAATGCCATTTCACCTGGAACTTATTCAAGGAAGACAGTGTCTCAAGGGATCTAGAAGAT
AGAGTGTGTAACCAGATTGAATTTTTAAACACTGAGTTCAAAGCTACAATGTACAACTTGTTGGCCTACATAAAACACCTAGATGGTAAC
AACGAGGCAGCCCTGGAATGCTTACGGCAAGCTGAAGAGTTAATCCAGCAAGAACATGCTGACCAAGCAGAAATCAGAAGTCTAGTCACT
TGGGGAAACTACGCCTGGGTCTACTATCACTTGGGCAGACTCTCAGATGCTCAGATTTATGTAGATAAGGTGAAACAAACCTGCAAGAAA
TTTTCAAATCCATACAGTATTGAGTATTCTGAACTTGACTGTGAGGAAGGGTGGACACAACTGAAGTGTGGAAGAAATGAAAGGGCGAAG
GTGTGTTTTGAGAAGGCTCTGGAAGAAAAGCCCAACAACCCAGAATTCTCCTCTGGACTGGCAATTGCGATGTACCATCTGGATAATCAC
CCAGAGAAACAGTTCTCTACTGATGTTTTGAAGCAGGCCATTGAGCTGAGTCCTGATAACCAATACGTCAAGGTTCTCTTGGGCCTGAAA
CTGCAGAAGATGAATAAAGAAGCTGAAGGAGAGCAGTTTGTTGAAGAAGCCTTGGAAAAGTCTCCTTGCCAAACAGATGTCCTCCGCAGT
GCAGCCAAATTTTACAGAAGAAAAGGTGACCTAGACAAAGCTATTGAACTGTTTCAACGGGTGTTGGAATCCACACCAAACAATGGCTAC
CTCTATCACCAGATTGGGTGCTGCTACAAGGCAAAAGTAAGACAAATGCAGAATACAGGAGAATCTGAAGCTAGTGGAAATAAAGAGATG
ATTGAAGCACTAAAGCAATATGCTATGGACTATTCGAATAAAGCTCTTGAGAAGGGACTGAATCCTCTGAATGCATACTCCGATCTCGCT
GAGTTCCTGGAGACGGAATGTTATCAGACACCATTCAATAAGGAAGTCCCTGATGCTGAAAAGCAACAATCCCATCAGCGCTACTGCAAC
CTTCAGAAATATAATGGGAAGTCTGAAGACACTGCTGTGCAACATGGTTTAGAGGGTTTGTCCATAAGCAAAAAATCAACTGACAAGGAA
GAGATCAAAGACCAACCACAGAATGTATCTGAAAATCTGCTTCCACAAAATGCACCAAATTATTGGTATCTTCAAGGATTAATTCATAAG
CAGAATGGAGATCTGCTGCAAGCAGCCAAATGTTATGAGAAGGAACTGGGCCGCCTGCTAAGGGATGCCCCTTCAGGCATAGGCAGTATT
TTCCTGTCAGCATCTGAGCTTGAGGATGGTAGTGAGGAAATGGGCCAGGGCGCAGTCAGCTCCAGTCCCAGAGAGCTCCTCTCTAACTCA
GAGCAACTGAACTGAGACAGAGGAGGAAAACAGAGCATCAGAAGCCTGCAGTGGTGGTTGTGACGGGTAGGACGATAGGAAGACAGGGGG
CCCCAACCTGGGATTGCTGAGCAGGGAAGCTTTGCATGTTGCTCTAAGGTACATTTTTAAAGAGTTGTTTTTTGGCCGGGCGCAGTGGCT
CATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACGAGGTCTGGAGTTTGAGACCATCCTGGCTAACACAGTGAAATC
CCGTCTCTACTAAAAATACAAAAAATTAGCCAGGCGTGGTGGCTGGCACCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGG
CGTGAACCTGGAAGGAAGAGGTTGCAGTGAGCCAAGATTGCGCCCCTGCACTCCAGCCTGGGCAACAGAGCAAGACTCCATCTCAAAAAA
AAAAAAAAAAAAAAAAAAGAGTTGTTTTCTCATGTTCATTATAGTTCATTACAGTTACATAGTCCGAAGGTCTTACAACTAATCACTGGT
AGCAATAAATGCTTCAGGCCCACATGATGCTGATTAGTTCTCAGTTTTCATTCAGTTCACAATATAACCACCATTCCTGCCCTCCCTGCC
AAGGGTCATAAATGGTGACTGCCTAACAACAAAATTTGCAGTCTCATCTCATTTTCATCCAGACTTCTGGAACTCAAAGATTAACTTTTG
ACTAACCCTGGAATATCTCTTATCTCACTTATAGCTTCAGGCATGTATTTATATGTATTCTTGATAGCAATACCATAATCAATGTGTATT

>In-frame_ENST00000404039_ENST00000371811_TCGA-QR-A70V-01A_DPP6_chr7_154461151_-_IFIT3_chr10_91098418_length(amino acids)=517AA_start in transcript=1071_stop in transcript=2624
MGILKVWTHQKSAMQNFSMQDGALKANSCEVTKNSLEKILPQLKCHFTWNLFKEDSVSRDLEDRVCNQIEFLNTEFKATMYNLLAYIKHL
DGNNEAALECLRQAEELIQQEHADQAEIRSLVTWGNYAWVYYHLGRLSDAQIYVDKVKQTCKKFSNPYSIEYSELDCEEGWTQLKCGRNE
RAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPEKQFSTDVLKQAIELSPDNQYVKVLLGLKLQKMNKEAEGEQFVEEALEKSPCQTDV
LRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYLYHQIGCCYKAKVRQMQNTGESEASGNKEMIEALKQYAMDYSNKALEKGLNPLNAYS
DLAEFLETECYQTPFNKEVPDAEKQQSHQRYCNLQKYNGKSEDTAVQHGLEGLSISKKSTDKEEIKDQPQNVSENLLPQNAPNYWYLQGL

--------------------------------------------------------------
>In-frame_ENST00000377770_ENST00000371818_TCGA-QR-A70V-01A_DPP6_chr7_154461151_-_IFIT3_chr10_91098418_length(transcript)=3214nt_BP=903nt
GCTTGCCTTGCTGCTGCTGCTGCTGCTGCCTCCCCACCGCCTTTTTTTTTTTTTAATCTGGAGCGGGGTGGGGAGTGGGAACCGGAGAGA
AAGCAAAATATTAAAAAGCCCCAAAGACAGCCAGCAGGAGCGCGGTGCCCGATGGCTTCGCTGTACCAGAGGTTCACTGGCAAGATCAAC
ACCTCGAGGTCCTTCCCCGCGCCCCCGGAGGCGAGTCACCTCCTGGGCGGCCAGGGGCCCGAGGAGGACGGCGGCGCAGGAGCCAAGCCC
CTCGGCCCGCGGGCGCAGGCGGCGGCGCCCCGGGAGCGCGGCGGCGGCGGCGGCGGCGCGGGTGGCCGGCCCCGGTTCCAGTACCAGGCG
CGGAGCGATGGTGACGAGGAGGACGAGCTGGTGGGGAGTAACCCTCCGCAGAGGAATTGGAAAGGAATAGCAATTGCACTGCTTGTCATT
CTGGTCATCTGCTCCTTGATCGTCACCTCGGTCATACTTCTGACACCAGCGGAAGATAATAGTCTGTCTCAAAAGAAGAAGGTCACTGTA
GAAGATCTCTTCAGTGAAGACTTCAAAATTCATGACCCCGAGGCTAAGTGGATAAGTGATACAGAATTCATCTACAGAGAACAGAAAGGA
ACAGTGAGACTGTGGAATGTTGAAACAAATACTTCTACTGTCTTAATAGAAGGCAAAAAAATTGAATCATTAAGAGCCATCAGATATGAA
ATATCTCCAGATAGAGAGTATGCACTTTTTTCATACAATGTGGAACCCATATATCAACACTCGTATACTGGATATTACGTCCTGAGCAAA
ATTCCTCATGGGGATCCTCAAAGTCTGGACCCACCAGAAGTCAGCAATGCAAAACTTCAGTATGCAGGATGGGGCCCTAAAGGCCAACAG
CTGTGAGGTCACCAAGAATTCCCTGGAGAAAATCCTTCCACAGCTGAAATGCCATTTCACCTGGAACTTATTCAAGGAAGACAGTGTCTC
AAGGGATCTAGAAGATAGAGTGTGTAACCAGATTGAATTTTTAAACACTGAGTTCAAAGCTACAATGTACAACTTGTTGGCCTACATAAA
ACACCTAGATGGTAACAACGAGGCAGCCCTGGAATGCTTACGGCAAGCTGAAGAGTTAATCCAGCAAGAACATGCTGACCAAGCAGAAAT
CAGAAGTCTAGTCACTTGGGGAAACTACGCCTGGGTCTACTATCACTTGGGCAGACTCTCAGATGCTCAGATTTATGTAGATAAGGTGAA
ACAAACCTGCAAGAAATTTTCAAATCCATACAGTATTGAGTATTCTGAACTTGACTGTGAGGAAGGGTGGACACAACTGAAGTGTGGAAG
AAATGAAAGGGCGAAGGTGTGTTTTGAGAAGGCTCTGGAAGAAAAGCCCAACAACCCAGAATTCTCCTCTGGACTGGCAATTGCGATGTA
CCATCTGGATAATCACCCAGAGAAACAGTTCTCTACTGATGTTTTGAAGCAGGCCATTGAGCTGAGTCCTGATAACCAATACGTCAAGGT
TCTCTTGGGCCTGAAACTGCAGAAGATGAATAAAGAAGCTGAAGGAGAGCAGTTTGTTGAAGAAGCCTTGGAAAAGTCTCCTTGCCAAAC
AGATGTCCTCCGCAGTGCAGCCAAATTTTACAGAAGAAAAGGTGACCTAGACAAAGCTATTGAACTGTTTCAACGGGTGTTGGAATCCAC
ACCAAACAATGGCTACCTCTATCACCAGATTGGGTGCTGCTACAAGGCAAAAGTAAGACAAATGCAGAATACAGGAGAATCTGAAGCTAG
TGGAAATAAAGAGATGATTGAAGCACTAAAGCAATATGCTATGGACTATTCGAATAAAGCTCTTGAGAAGGGACTGAATCCTCTGAATGC
ATACTCCGATCTCGCTGAGTTCCTGGAGACGGAATGTTATCAGACACCATTCAATAAGGAAGTCCCTGATGCTGAAAAGCAACAATCCCA
TCAGCGCTACTGCAACCTTCAGAAATATAATGGGAAGTCTGAAGACACTGCTGTGCAACATGGTTTAGAGGGTTTGTCCATAAGCAAAAA
ATCAACTGACAAGGAAGAGATCAAAGACCAACCACAGAATGTATCTGAAAATCTGCTTCCACAAAATGCACCAAATTATTGGTATCTTCA
AGGATTAATTCATAAGCAGAATGGAGATCTGCTGCAAGCAGCCAAATGTTATGAGAAGGAACTGGGCCGCCTGCTAAGGGATGCCCCTTC
AGGCATAGGCAGTATTTTCCTGTCAGCATCTGAGCTTGAGGATGGTAGTGAGGAAATGGGCCAGGGCGCAGTCAGCTCCAGTCCCAGAGA
GCTCCTCTCTAACTCAGAGCAACTGAACTGAGACAGAGGAGGAAAACAGAGCATCAGAAGCCTGCAGTGGTGGTTGTGACGGGTAGGACG
ATAGGAAGACAGGGGGCCCCAACCTGGGATTGCTGAGCAGGGAAGCTTTGCATGTTGCTCTAAGGTACATTTTTAAAGAGTTGTTTTTTG
GCCGGGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACGAGGTCTGGAGTTTGAGACCATCCTGG
CTAACACAGTGAAATCCCGTCTCTACTAAAAATACAAAAAATTAGCCAGGCGTGGTGGCTGGCACCTGTAGTCCCAGCTACTTGGGAGGC
TGAGGCAGGAGAATGGCGTGAACCTGGAAGGAAGAGGTTGCAGTGAGCCAAGATTGCGCCCCTGCACTCCAGCCTGGGCAACAGAGCAAG
ACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAGAGTTGTTTTCTCATGTTCATTATAGTTCATTACAGTTACATAGTCCGAAGGTCTT
ACAACTAATCACTGGTAGCAATAAATGCTTCAGGCCCACATGATGCTGATTAGTTCTCAGTTTTCATTCAGTTCACAATATAACCACCAT
TCCTGCCCTCCCTGCCAAGGGTCATAAATGGTGACTGCCTAACAACAAAATTTGCAGTCTCATCTCATTTTCATCCAGACTTCTGGAACT
CAAAGATTAACTTTTGACTAACCCTGGAATATCTCTTATCTCACTTATAGCTTCAGGCATGTATTTATATGTATTCTTGATAGCAATACC

>In-frame_ENST00000377770_ENST00000371818_TCGA-QR-A70V-01A_DPP6_chr7_154461151_-_IFIT3_chr10_91098418_length(amino acids)=517AA_start in transcript=817_stop in transcript=2370
MGILKVWTHQKSAMQNFSMQDGALKANSCEVTKNSLEKILPQLKCHFTWNLFKEDSVSRDLEDRVCNQIEFLNTEFKATMYNLLAYIKHL
DGNNEAALECLRQAEELIQQEHADQAEIRSLVTWGNYAWVYYHLGRLSDAQIYVDKVKQTCKKFSNPYSIEYSELDCEEGWTQLKCGRNE
RAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPEKQFSTDVLKQAIELSPDNQYVKVLLGLKLQKMNKEAEGEQFVEEALEKSPCQTDV
LRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYLYHQIGCCYKAKVRQMQNTGESEASGNKEMIEALKQYAMDYSNKALEKGLNPLNAYS
DLAEFLETECYQTPFNKEVPDAEKQQSHQRYCNLQKYNGKSEDTAVQHGLEGLSISKKSTDKEEIKDQPQNVSENLLPQNAPNYWYLQGL

--------------------------------------------------------------
>In-frame_ENST00000377770_ENST00000371811_TCGA-QR-A70V-01A_DPP6_chr7_154461151_-_IFIT3_chr10_91098418_length(transcript)=3214nt_BP=903nt
GCTTGCCTTGCTGCTGCTGCTGCTGCTGCCTCCCCACCGCCTTTTTTTTTTTTTAATCTGGAGCGGGGTGGGGAGTGGGAACCGGAGAGA
AAGCAAAATATTAAAAAGCCCCAAAGACAGCCAGCAGGAGCGCGGTGCCCGATGGCTTCGCTGTACCAGAGGTTCACTGGCAAGATCAAC
ACCTCGAGGTCCTTCCCCGCGCCCCCGGAGGCGAGTCACCTCCTGGGCGGCCAGGGGCCCGAGGAGGACGGCGGCGCAGGAGCCAAGCCC
CTCGGCCCGCGGGCGCAGGCGGCGGCGCCCCGGGAGCGCGGCGGCGGCGGCGGCGGCGCGGGTGGCCGGCCCCGGTTCCAGTACCAGGCG
CGGAGCGATGGTGACGAGGAGGACGAGCTGGTGGGGAGTAACCCTCCGCAGAGGAATTGGAAAGGAATAGCAATTGCACTGCTTGTCATT
CTGGTCATCTGCTCCTTGATCGTCACCTCGGTCATACTTCTGACACCAGCGGAAGATAATAGTCTGTCTCAAAAGAAGAAGGTCACTGTA
GAAGATCTCTTCAGTGAAGACTTCAAAATTCATGACCCCGAGGCTAAGTGGATAAGTGATACAGAATTCATCTACAGAGAACAGAAAGGA
ACAGTGAGACTGTGGAATGTTGAAACAAATACTTCTACTGTCTTAATAGAAGGCAAAAAAATTGAATCATTAAGAGCCATCAGATATGAA
ATATCTCCAGATAGAGAGTATGCACTTTTTTCATACAATGTGGAACCCATATATCAACACTCGTATACTGGATATTACGTCCTGAGCAAA
ATTCCTCATGGGGATCCTCAAAGTCTGGACCCACCAGAAGTCAGCAATGCAAAACTTCAGTATGCAGGATGGGGCCCTAAAGGCCAACAG
CTGTGAGGTCACCAAGAATTCCCTGGAGAAAATCCTTCCACAGCTGAAATGCCATTTCACCTGGAACTTATTCAAGGAAGACAGTGTCTC
AAGGGATCTAGAAGATAGAGTGTGTAACCAGATTGAATTTTTAAACACTGAGTTCAAAGCTACAATGTACAACTTGTTGGCCTACATAAA
ACACCTAGATGGTAACAACGAGGCAGCCCTGGAATGCTTACGGCAAGCTGAAGAGTTAATCCAGCAAGAACATGCTGACCAAGCAGAAAT
CAGAAGTCTAGTCACTTGGGGAAACTACGCCTGGGTCTACTATCACTTGGGCAGACTCTCAGATGCTCAGATTTATGTAGATAAGGTGAA
ACAAACCTGCAAGAAATTTTCAAATCCATACAGTATTGAGTATTCTGAACTTGACTGTGAGGAAGGGTGGACACAACTGAAGTGTGGAAG
AAATGAAAGGGCGAAGGTGTGTTTTGAGAAGGCTCTGGAAGAAAAGCCCAACAACCCAGAATTCTCCTCTGGACTGGCAATTGCGATGTA
CCATCTGGATAATCACCCAGAGAAACAGTTCTCTACTGATGTTTTGAAGCAGGCCATTGAGCTGAGTCCTGATAACCAATACGTCAAGGT
TCTCTTGGGCCTGAAACTGCAGAAGATGAATAAAGAAGCTGAAGGAGAGCAGTTTGTTGAAGAAGCCTTGGAAAAGTCTCCTTGCCAAAC
AGATGTCCTCCGCAGTGCAGCCAAATTTTACAGAAGAAAAGGTGACCTAGACAAAGCTATTGAACTGTTTCAACGGGTGTTGGAATCCAC
ACCAAACAATGGCTACCTCTATCACCAGATTGGGTGCTGCTACAAGGCAAAAGTAAGACAAATGCAGAATACAGGAGAATCTGAAGCTAG
TGGAAATAAAGAGATGATTGAAGCACTAAAGCAATATGCTATGGACTATTCGAATAAAGCTCTTGAGAAGGGACTGAATCCTCTGAATGC
ATACTCCGATCTCGCTGAGTTCCTGGAGACGGAATGTTATCAGACACCATTCAATAAGGAAGTCCCTGATGCTGAAAAGCAACAATCCCA
TCAGCGCTACTGCAACCTTCAGAAATATAATGGGAAGTCTGAAGACACTGCTGTGCAACATGGTTTAGAGGGTTTGTCCATAAGCAAAAA
ATCAACTGACAAGGAAGAGATCAAAGACCAACCACAGAATGTATCTGAAAATCTGCTTCCACAAAATGCACCAAATTATTGGTATCTTCA
AGGATTAATTCATAAGCAGAATGGAGATCTGCTGCAAGCAGCCAAATGTTATGAGAAGGAACTGGGCCGCCTGCTAAGGGATGCCCCTTC
AGGCATAGGCAGTATTTTCCTGTCAGCATCTGAGCTTGAGGATGGTAGTGAGGAAATGGGCCAGGGCGCAGTCAGCTCCAGTCCCAGAGA
GCTCCTCTCTAACTCAGAGCAACTGAACTGAGACAGAGGAGGAAAACAGAGCATCAGAAGCCTGCAGTGGTGGTTGTGACGGGTAGGACG
ATAGGAAGACAGGGGGCCCCAACCTGGGATTGCTGAGCAGGGAAGCTTTGCATGTTGCTCTAAGGTACATTTTTAAAGAGTTGTTTTTTG
GCCGGGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACGAGGTCTGGAGTTTGAGACCATCCTGG
CTAACACAGTGAAATCCCGTCTCTACTAAAAATACAAAAAATTAGCCAGGCGTGGTGGCTGGCACCTGTAGTCCCAGCTACTTGGGAGGC
TGAGGCAGGAGAATGGCGTGAACCTGGAAGGAAGAGGTTGCAGTGAGCCAAGATTGCGCCCCTGCACTCCAGCCTGGGCAACAGAGCAAG
ACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAGAGTTGTTTTCTCATGTTCATTATAGTTCATTACAGTTACATAGTCCGAAGGTCTT
ACAACTAATCACTGGTAGCAATAAATGCTTCAGGCCCACATGATGCTGATTAGTTCTCAGTTTTCATTCAGTTCACAATATAACCACCAT
TCCTGCCCTCCCTGCCAAGGGTCATAAATGGTGACTGCCTAACAACAAAATTTGCAGTCTCATCTCATTTTCATCCAGACTTCTGGAACT
CAAAGATTAACTTTTGACTAACCCTGGAATATCTCTTATCTCACTTATAGCTTCAGGCATGTATTTATATGTATTCTTGATAGCAATACC

>In-frame_ENST00000377770_ENST00000371811_TCGA-QR-A70V-01A_DPP6_chr7_154461151_-_IFIT3_chr10_91098418_length(amino acids)=517AA_start in transcript=817_stop in transcript=2370
MGILKVWTHQKSAMQNFSMQDGALKANSCEVTKNSLEKILPQLKCHFTWNLFKEDSVSRDLEDRVCNQIEFLNTEFKATMYNLLAYIKHL
DGNNEAALECLRQAEELIQQEHADQAEIRSLVTWGNYAWVYYHLGRLSDAQIYVDKVKQTCKKFSNPYSIEYSELDCEEGWTQLKCGRNE
RAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPEKQFSTDVLKQAIELSPDNQYVKVLLGLKLQKMNKEAEGEQFVEEALEKSPCQTDV
LRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYLYHQIGCCYKAKVRQMQNTGESEASGNKEMIEALKQYAMDYSNKALEKGLNPLNAYS
DLAEFLETECYQTPFNKEVPDAEKQQSHQRYCNLQKYNGKSEDTAVQHGLEGLSISKKSTDKEEIKDQPQNVSENLLPQNAPNYWYLQGL

--------------------------------------------------------------
>In-frame_ENST00000332007_ENST00000371818_TCGA-QR-A70V-01A_DPP6_chr7_154461151_-_IFIT3_chr10_91098418_length(transcript)=3272nt_BP=961nt
TGCGCCGTGGGCGCCGGGCCGGGAGGCGGGCGAGGAGGCAGCGCGCATCACTCGGGTCCCCTTCCTGCACCCAGCCGCCACTTGCCGGTT
GCTAAGCAGTTATCATTGTTTCTGTGGCGATTGCAGAGGCTGTTGCTAATTGGAGAAGCCCCACTAAGCAGCGGCAGCTTCCTGCTTCGG
ATCCTCTCTCTGCTGCTTGCATTTAAAGAGCAAACTCGTCTTGTCTACCCACCCTCCCTCCCCCATCCTCCCCAAAATAGCCTTGTGATT
TCGGAAGTATGGACTAAAATCACACTCCTCCTTACCTTACCGCTTGGACTCTGGTGGCTCCCAACTCGCCGTCAGACCCCACCTGCCCCG
GTGGTGGGAAGCGCCTGGACAGACCATGACCACAGCCAAGGAGCCAAGCGCTTCGGGGAAATCCGTGCAGCAGCAGGAACAGGAGCTGGT
GGGGAGTAACCCTCCGCAGAGGAATTGGAAAGGAATAGCAATTGCACTGCTTGTCATTCTGGTCATCTGCTCCTTGATCGTCACCTCGGT
CATACTTCTGACACCAGCGGAAGATAATAGTCTGTCTCAAAAGAAGAAGGTCACTGTAGAAGATCTCTTCAGTGAAGACTTCAAAATTCA
TGACCCCGAGGCTAAGTGGATAAGTGATACAGAATTCATCTACAGAGAACAGAAAGGAACAGTGAGACTGTGGAATGTTGAAACAAATAC
TTCTACTGTCTTAATAGAAGGCAAAAAAATTGAATCATTAAGAGCCATCAGATATGAAATATCTCCAGATAGAGAGTATGCACTTTTTTC
ATACAATGTGGAACCCATATATCAACACTCGTATACTGGATATTACGTCCTGAGCAAAATTCCTCATGGGGATCCTCAAAGTCTGGACCC
ACCAGAAGTCAGCAATGCAAAACTTCAGTATGCAGGATGGGGCCCTAAAGGCCAACAGCTGTGAGGTCACCAAGAATTCCCTGGAGAAAA
TCCTTCCACAGCTGAAATGCCATTTCACCTGGAACTTATTCAAGGAAGACAGTGTCTCAAGGGATCTAGAAGATAGAGTGTGTAACCAGA
TTGAATTTTTAAACACTGAGTTCAAAGCTACAATGTACAACTTGTTGGCCTACATAAAACACCTAGATGGTAACAACGAGGCAGCCCTGG
AATGCTTACGGCAAGCTGAAGAGTTAATCCAGCAAGAACATGCTGACCAAGCAGAAATCAGAAGTCTAGTCACTTGGGGAAACTACGCCT
GGGTCTACTATCACTTGGGCAGACTCTCAGATGCTCAGATTTATGTAGATAAGGTGAAACAAACCTGCAAGAAATTTTCAAATCCATACA
GTATTGAGTATTCTGAACTTGACTGTGAGGAAGGGTGGACACAACTGAAGTGTGGAAGAAATGAAAGGGCGAAGGTGTGTTTTGAGAAGG
CTCTGGAAGAAAAGCCCAACAACCCAGAATTCTCCTCTGGACTGGCAATTGCGATGTACCATCTGGATAATCACCCAGAGAAACAGTTCT
CTACTGATGTTTTGAAGCAGGCCATTGAGCTGAGTCCTGATAACCAATACGTCAAGGTTCTCTTGGGCCTGAAACTGCAGAAGATGAATA
AAGAAGCTGAAGGAGAGCAGTTTGTTGAAGAAGCCTTGGAAAAGTCTCCTTGCCAAACAGATGTCCTCCGCAGTGCAGCCAAATTTTACA
GAAGAAAAGGTGACCTAGACAAAGCTATTGAACTGTTTCAACGGGTGTTGGAATCCACACCAAACAATGGCTACCTCTATCACCAGATTG
GGTGCTGCTACAAGGCAAAAGTAAGACAAATGCAGAATACAGGAGAATCTGAAGCTAGTGGAAATAAAGAGATGATTGAAGCACTAAAGC
AATATGCTATGGACTATTCGAATAAAGCTCTTGAGAAGGGACTGAATCCTCTGAATGCATACTCCGATCTCGCTGAGTTCCTGGAGACGG
AATGTTATCAGACACCATTCAATAAGGAAGTCCCTGATGCTGAAAAGCAACAATCCCATCAGCGCTACTGCAACCTTCAGAAATATAATG
GGAAGTCTGAAGACACTGCTGTGCAACATGGTTTAGAGGGTTTGTCCATAAGCAAAAAATCAACTGACAAGGAAGAGATCAAAGACCAAC
CACAGAATGTATCTGAAAATCTGCTTCCACAAAATGCACCAAATTATTGGTATCTTCAAGGATTAATTCATAAGCAGAATGGAGATCTGC
TGCAAGCAGCCAAATGTTATGAGAAGGAACTGGGCCGCCTGCTAAGGGATGCCCCTTCAGGCATAGGCAGTATTTTCCTGTCAGCATCTG
AGCTTGAGGATGGTAGTGAGGAAATGGGCCAGGGCGCAGTCAGCTCCAGTCCCAGAGAGCTCCTCTCTAACTCAGAGCAACTGAACTGAG
ACAGAGGAGGAAAACAGAGCATCAGAAGCCTGCAGTGGTGGTTGTGACGGGTAGGACGATAGGAAGACAGGGGGCCCCAACCTGGGATTG
CTGAGCAGGGAAGCTTTGCATGTTGCTCTAAGGTACATTTTTAAAGAGTTGTTTTTTGGCCGGGCGCAGTGGCTCATGCCTGTAATCCCA
GCACTTTGGGAGGCCGAGGTGGGCGGATCACGAGGTCTGGAGTTTGAGACCATCCTGGCTAACACAGTGAAATCCCGTCTCTACTAAAAA
TACAAAAAATTAGCCAGGCGTGGTGGCTGGCACCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCGTGAACCTGGAAGGA
AGAGGTTGCAGTGAGCCAAGATTGCGCCCCTGCACTCCAGCCTGGGCAACAGAGCAAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAA
AAGAGTTGTTTTCTCATGTTCATTATAGTTCATTACAGTTACATAGTCCGAAGGTCTTACAACTAATCACTGGTAGCAATAAATGCTTCA
GGCCCACATGATGCTGATTAGTTCTCAGTTTTCATTCAGTTCACAATATAACCACCATTCCTGCCCTCCCTGCCAAGGGTCATAAATGGT
GACTGCCTAACAACAAAATTTGCAGTCTCATCTCATTTTCATCCAGACTTCTGGAACTCAAAGATTAACTTTTGACTAACCCTGGAATAT
CTCTTATCTCACTTATAGCTTCAGGCATGTATTTATATGTATTCTTGATAGCAATACCATAATCAATGTGTATTCCTGATAGTAATGCTA

>In-frame_ENST00000332007_ENST00000371818_TCGA-QR-A70V-01A_DPP6_chr7_154461151_-_IFIT3_chr10_91098418_length(amino acids)=517AA_start in transcript=875_stop in transcript=2428
MGILKVWTHQKSAMQNFSMQDGALKANSCEVTKNSLEKILPQLKCHFTWNLFKEDSVSRDLEDRVCNQIEFLNTEFKATMYNLLAYIKHL
DGNNEAALECLRQAEELIQQEHADQAEIRSLVTWGNYAWVYYHLGRLSDAQIYVDKVKQTCKKFSNPYSIEYSELDCEEGWTQLKCGRNE
RAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPEKQFSTDVLKQAIELSPDNQYVKVLLGLKLQKMNKEAEGEQFVEEALEKSPCQTDV
LRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYLYHQIGCCYKAKVRQMQNTGESEASGNKEMIEALKQYAMDYSNKALEKGLNPLNAYS
DLAEFLETECYQTPFNKEVPDAEKQQSHQRYCNLQKYNGKSEDTAVQHGLEGLSISKKSTDKEEIKDQPQNVSENLLPQNAPNYWYLQGL

--------------------------------------------------------------
>In-frame_ENST00000332007_ENST00000371811_TCGA-QR-A70V-01A_DPP6_chr7_154461151_-_IFIT3_chr10_91098418_length(transcript)=3272nt_BP=961nt
TGCGCCGTGGGCGCCGGGCCGGGAGGCGGGCGAGGAGGCAGCGCGCATCACTCGGGTCCCCTTCCTGCACCCAGCCGCCACTTGCCGGTT
GCTAAGCAGTTATCATTGTTTCTGTGGCGATTGCAGAGGCTGTTGCTAATTGGAGAAGCCCCACTAAGCAGCGGCAGCTTCCTGCTTCGG
ATCCTCTCTCTGCTGCTTGCATTTAAAGAGCAAACTCGTCTTGTCTACCCACCCTCCCTCCCCCATCCTCCCCAAAATAGCCTTGTGATT
TCGGAAGTATGGACTAAAATCACACTCCTCCTTACCTTACCGCTTGGACTCTGGTGGCTCCCAACTCGCCGTCAGACCCCACCTGCCCCG
GTGGTGGGAAGCGCCTGGACAGACCATGACCACAGCCAAGGAGCCAAGCGCTTCGGGGAAATCCGTGCAGCAGCAGGAACAGGAGCTGGT
GGGGAGTAACCCTCCGCAGAGGAATTGGAAAGGAATAGCAATTGCACTGCTTGTCATTCTGGTCATCTGCTCCTTGATCGTCACCTCGGT
CATACTTCTGACACCAGCGGAAGATAATAGTCTGTCTCAAAAGAAGAAGGTCACTGTAGAAGATCTCTTCAGTGAAGACTTCAAAATTCA
TGACCCCGAGGCTAAGTGGATAAGTGATACAGAATTCATCTACAGAGAACAGAAAGGAACAGTGAGACTGTGGAATGTTGAAACAAATAC
TTCTACTGTCTTAATAGAAGGCAAAAAAATTGAATCATTAAGAGCCATCAGATATGAAATATCTCCAGATAGAGAGTATGCACTTTTTTC
ATACAATGTGGAACCCATATATCAACACTCGTATACTGGATATTACGTCCTGAGCAAAATTCCTCATGGGGATCCTCAAAGTCTGGACCC
ACCAGAAGTCAGCAATGCAAAACTTCAGTATGCAGGATGGGGCCCTAAAGGCCAACAGCTGTGAGGTCACCAAGAATTCCCTGGAGAAAA
TCCTTCCACAGCTGAAATGCCATTTCACCTGGAACTTATTCAAGGAAGACAGTGTCTCAAGGGATCTAGAAGATAGAGTGTGTAACCAGA
TTGAATTTTTAAACACTGAGTTCAAAGCTACAATGTACAACTTGTTGGCCTACATAAAACACCTAGATGGTAACAACGAGGCAGCCCTGG
AATGCTTACGGCAAGCTGAAGAGTTAATCCAGCAAGAACATGCTGACCAAGCAGAAATCAGAAGTCTAGTCACTTGGGGAAACTACGCCT
GGGTCTACTATCACTTGGGCAGACTCTCAGATGCTCAGATTTATGTAGATAAGGTGAAACAAACCTGCAAGAAATTTTCAAATCCATACA
GTATTGAGTATTCTGAACTTGACTGTGAGGAAGGGTGGACACAACTGAAGTGTGGAAGAAATGAAAGGGCGAAGGTGTGTTTTGAGAAGG
CTCTGGAAGAAAAGCCCAACAACCCAGAATTCTCCTCTGGACTGGCAATTGCGATGTACCATCTGGATAATCACCCAGAGAAACAGTTCT
CTACTGATGTTTTGAAGCAGGCCATTGAGCTGAGTCCTGATAACCAATACGTCAAGGTTCTCTTGGGCCTGAAACTGCAGAAGATGAATA
AAGAAGCTGAAGGAGAGCAGTTTGTTGAAGAAGCCTTGGAAAAGTCTCCTTGCCAAACAGATGTCCTCCGCAGTGCAGCCAAATTTTACA
GAAGAAAAGGTGACCTAGACAAAGCTATTGAACTGTTTCAACGGGTGTTGGAATCCACACCAAACAATGGCTACCTCTATCACCAGATTG
GGTGCTGCTACAAGGCAAAAGTAAGACAAATGCAGAATACAGGAGAATCTGAAGCTAGTGGAAATAAAGAGATGATTGAAGCACTAAAGC
AATATGCTATGGACTATTCGAATAAAGCTCTTGAGAAGGGACTGAATCCTCTGAATGCATACTCCGATCTCGCTGAGTTCCTGGAGACGG
AATGTTATCAGACACCATTCAATAAGGAAGTCCCTGATGCTGAAAAGCAACAATCCCATCAGCGCTACTGCAACCTTCAGAAATATAATG
GGAAGTCTGAAGACACTGCTGTGCAACATGGTTTAGAGGGTTTGTCCATAAGCAAAAAATCAACTGACAAGGAAGAGATCAAAGACCAAC
CACAGAATGTATCTGAAAATCTGCTTCCACAAAATGCACCAAATTATTGGTATCTTCAAGGATTAATTCATAAGCAGAATGGAGATCTGC
TGCAAGCAGCCAAATGTTATGAGAAGGAACTGGGCCGCCTGCTAAGGGATGCCCCTTCAGGCATAGGCAGTATTTTCCTGTCAGCATCTG
AGCTTGAGGATGGTAGTGAGGAAATGGGCCAGGGCGCAGTCAGCTCCAGTCCCAGAGAGCTCCTCTCTAACTCAGAGCAACTGAACTGAG
ACAGAGGAGGAAAACAGAGCATCAGAAGCCTGCAGTGGTGGTTGTGACGGGTAGGACGATAGGAAGACAGGGGGCCCCAACCTGGGATTG
CTGAGCAGGGAAGCTTTGCATGTTGCTCTAAGGTACATTTTTAAAGAGTTGTTTTTTGGCCGGGCGCAGTGGCTCATGCCTGTAATCCCA
GCACTTTGGGAGGCCGAGGTGGGCGGATCACGAGGTCTGGAGTTTGAGACCATCCTGGCTAACACAGTGAAATCCCGTCTCTACTAAAAA
TACAAAAAATTAGCCAGGCGTGGTGGCTGGCACCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCGTGAACCTGGAAGGA
AGAGGTTGCAGTGAGCCAAGATTGCGCCCCTGCACTCCAGCCTGGGCAACAGAGCAAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAA
AAGAGTTGTTTTCTCATGTTCATTATAGTTCATTACAGTTACATAGTCCGAAGGTCTTACAACTAATCACTGGTAGCAATAAATGCTTCA
GGCCCACATGATGCTGATTAGTTCTCAGTTTTCATTCAGTTCACAATATAACCACCATTCCTGCCCTCCCTGCCAAGGGTCATAAATGGT
GACTGCCTAACAACAAAATTTGCAGTCTCATCTCATTTTCATCCAGACTTCTGGAACTCAAAGATTAACTTTTGACTAACCCTGGAATAT
CTCTTATCTCACTTATAGCTTCAGGCATGTATTTATATGTATTCTTGATAGCAATACCATAATCAATGTGTATTCCTGATAGTAATGCTA

>In-frame_ENST00000332007_ENST00000371811_TCGA-QR-A70V-01A_DPP6_chr7_154461151_-_IFIT3_chr10_91098418_length(amino acids)=517AA_start in transcript=875_stop in transcript=2428
MGILKVWTHQKSAMQNFSMQDGALKANSCEVTKNSLEKILPQLKCHFTWNLFKEDSVSRDLEDRVCNQIEFLNTEFKATMYNLLAYIKHL
DGNNEAALECLRQAEELIQQEHADQAEIRSLVTWGNYAWVYYHLGRLSDAQIYVDKVKQTCKKFSNPYSIEYSELDCEEGWTQLKCGRNE
RAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPEKQFSTDVLKQAIELSPDNQYVKVLLGLKLQKMNKEAEGEQFVEEALEKSPCQTDV
LRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYLYHQIGCCYKAKVRQMQNTGESEASGNKEMIEALKQYAMDYSNKALEKGLNPLNAYS
DLAEFLETECYQTPFNKEVPDAEKQQSHQRYCNLQKYNGKSEDTAVQHGLEGLSISKKSTDKEEIKDQPQNVSENLLPQNAPNYWYLQGL

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Fusion Gene PPI Analysis for DPP6-IFIT3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for DPP6-IFIT3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for DPP6-IFIT3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	DPP6	C1510586	Autism Spectrum Disorders	2	CTD_human
Hgene	DPP6	C2751898	Ventricular Fibrillation, Paroxysmal Familial, 1	2	ORPHANET
Hgene	DPP6	C4017668	VENTRICULAR FIBRILLATION DURING MYOCARDIAL INFARCTION, SUSCEPTIBILITY TO	2	ORPHANET
Hgene	DPP6	C0002736	Amyotrophic Lateral Sclerosis	1	CTD_human
Hgene	DPP6	C0220693	Microcephaly autosomal dominant	1	ORPHANET
Hgene	DPP6	C0393554	Amyotrophic Lateral Sclerosis With Dementia	1	CTD_human
Hgene	DPP6	C0431350	Primary microcephaly	1	GENOMICS_ENGLAND
Hgene	DPP6	C0543859	Amyotrophic Lateral Sclerosis, Guam Form	1	CTD_human
Hgene	DPP6	C4225375	MENTAL RETARDATION, AUTOSOMAL DOMINANT 33	1	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	IFIT3	C0021400	Influenza	1	CTD_human