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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DPYD-STAB2 (FusionGDB2 ID:24087)

Fusion Gene Summary for DPYD-STAB2

check button Fusion gene summary
Fusion gene informationFusion gene name: DPYD-STAB2
Fusion gene ID: 24087
HgeneTgene
Gene symbol

DPYD

STAB2

Gene ID

1806

55576

Gene namedihydropyrimidine dehydrogenasestabilin 2
SynonymsDHP|DHPDHASE|DPDFEEL2|FELE-2|FELL2|FEX2|HARE|SCARH1
Cytomap

1p21.3

12q23.3

Type of geneprotein-codingprotein-coding
Descriptiondihydropyrimidine dehydrogenase [NADP(+)]dihydrothymine dehydrogenasedihydrouracil dehydrogenasestabilin-2CD44-like precursor FELLFAS1 EGF-like and X-link domain containing adhesion molecule-2fasciclin egf-like, laminin-type egf-like, and link domain-containing scavenger receptor-2hepatic hyaluronan clearance receptorhyaluronan receptor for end
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000370192, ENST00000474241, 
ENST00000423006, ENST00000306031, 
ENST00000388887, 
Fusion gene scores* DoF score15 X 13 X 8=15607 X 8 X 3=168
# samples 186
** MAII scorelog2(18/1560*10)=-3.11547721741994
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/168*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DPYD [Title/Abstract] AND STAB2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDPYD(98348820)-STAB2(104054109), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDPYD

GO:0006210

thymine catabolic process

10410956

HgeneDPYD

GO:0006212

uracil catabolic process

1512248|18075467

HgeneDPYD

GO:0006214

thymidine catabolic process

1512248

TgeneSTAB2

GO:0042742

defense response to bacterium

12077138

TgeneSTAB2

GO:0050830

defense response to Gram-positive bacterium

11829752


check buttonFusion gene breakpoints across DPYD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across STAB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A1EU-01ADPYDchr1

98348820

-STAB2chr12

104054109

+
ChimerDB4BRCATCGA-BH-A1EU-01ADPYDchr1

98348820

-STAB2chr12

104054109

+
ChimerDB4BRCATCGA-BH-A1EU-01ADPYDchr1

98348820

-STAB2chr12

104054109

+


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Fusion Gene ORF analysis for DPYD-STAB2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000370192ENST00000388887DPYDchr1

98348820

-STAB2chr12

104054109

+
intron-3CDSENST00000474241ENST00000388887DPYDchr1

98348820

-STAB2chr12

104054109

+
intron-3CDSENST00000423006ENST00000388887DPYDchr1

98348820

-STAB2chr12

104054109

+
In-frameENST00000306031ENST00000388887DPYDchr1

98348820

-STAB2chr12

104054109

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000370192DPYDchr198348820-ENST00000388887STAB2chr12104054109+65642514761722041
ENST00000306031DPYDchr198348820-ENST00000388887STAB2chr12104054109+65902772261982058

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000370192ENST00000388887DPYDchr198348820-STAB2chr12104054109+0.0012178840.9987821
ENST00000306031ENST00000388887DPYDchr198348820-STAB2chr12104054109+0.0012609880.99873906

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Fusion Genomic Features for DPYD-STAB2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DPYDchr198348819-STAB2chr12104054108+0.364307880.6356921
DPYDchr198348819-STAB2chr12104054108+0.364307880.6356921

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DPYD-STAB2


check button Go to

FGviewer for the breakpoints of chr1:98348820-chr12:104054109

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSTAB2chr1:98348820chr12:104054109ENST0000038888714691137_1265578.02552.0DomainFAS1 4
TgeneSTAB2chr1:98348820chr12:104054109ENST0000038888714691343_1408578.02552.0DomainLaminin EGF-like 1
TgeneSTAB2chr1:98348820chr12:104054109ENST0000038888714691432_1470578.02552.0DomainEGF-like 11
TgeneSTAB2chr1:98348820chr12:104054109ENST0000038888714691471_1512578.02552.0DomainEGF-like 12
TgeneSTAB2chr1:98348820chr12:104054109ENST0000038888714691513_1554578.02552.0DomainEGF-like 13
TgeneSTAB2chr1:98348820chr12:104054109ENST0000038888714691555_1594578.02552.0DomainEGF-like 14
TgeneSTAB2chr1:98348820chr12:104054109ENST0000038888714691596_1724578.02552.0DomainFAS1 5
TgeneSTAB2chr1:98348820chr12:104054109ENST0000038888714691740_1881578.02552.0DomainFAS1 6
TgeneSTAB2chr1:98348820chr12:104054109ENST0000038888714691957_2022578.02552.0DomainLaminin EGF-like 2
TgeneSTAB2chr1:98348820chr12:104054109ENST0000038888714692047_2081578.02552.0DomainEGF-like 15
TgeneSTAB2chr1:98348820chr12:104054109ENST0000038888714692082_2122578.02552.0DomainEGF-like 16
TgeneSTAB2chr1:98348820chr12:104054109ENST0000038888714692123_2165578.02552.0DomainEGF-like 17
TgeneSTAB2chr1:98348820chr12:104054109ENST0000038888714692198_2291578.02552.0DomainLink
TgeneSTAB2chr1:98348820chr12:104054109ENST0000038888714692311_2446578.02552.0DomainFAS1 7
TgeneSTAB2chr1:98348820chr12:104054109ENST000003888871469736_776578.02552.0DomainEGF-like 6
TgeneSTAB2chr1:98348820chr12:104054109ENST000003888871469826_866578.02552.0DomainEGF-like 7
TgeneSTAB2chr1:98348820chr12:104054109ENST000003888871469867_909578.02552.0DomainEGF-like 8
TgeneSTAB2chr1:98348820chr12:104054109ENST000003888871469910_952578.02552.0DomainEGF-like 9
TgeneSTAB2chr1:98348820chr12:104054109ENST000003888871469953_992578.02552.0DomainEGF-like 10
TgeneSTAB2chr1:98348820chr12:104054109ENST000003888871469994_1127578.02552.0DomainFAS1 3
TgeneSTAB2chr1:98348820chr12:104054109ENST0000038888714692480_2551578.02552.0Topological domainCytoplasmic
TgeneSTAB2chr1:98348820chr12:104054109ENST0000038888714692459_2479578.02552.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDPYDchr1:98348820chr12:104054109ENST00000370192-22369_10050.01026.0Domain4Fe-4S ferredoxin-type 1
HgeneDPYDchr1:98348820chr12:104054109ENST00000370192-223944_97650.01026.0Domain4Fe-4S ferredoxin-type 2
HgeneDPYDchr1:98348820chr12:104054109ENST00000370192-223978_100750.01026.0Domain4Fe-4S ferredoxin-type 3
HgeneDPYDchr1:98348820chr12:104054109ENST00000370192-223194_19850.01026.0Nucleotide bindingFAD
HgeneDPYDchr1:98348820chr12:104054109ENST00000370192-223218_22650.01026.0Nucleotide bindingFAD
HgeneDPYDchr1:98348820chr12:104054109ENST00000370192-223340_34350.01026.0Nucleotide bindingNADP
HgeneDPYDchr1:98348820chr12:104054109ENST00000370192-223364_36550.01026.0Nucleotide bindingNADP
HgeneDPYDchr1:98348820chr12:104054109ENST00000370192-223437_43950.01026.0Nucleotide bindingNADP
HgeneDPYDchr1:98348820chr12:104054109ENST00000370192-223480_48950.01026.0Nucleotide bindingFAD
HgeneDPYDchr1:98348820chr12:104054109ENST00000370192-223481_48750.01026.0Nucleotide bindingNADP
HgeneDPYDchr1:98348820chr12:104054109ENST00000370192-223574_57550.01026.0Nucleotide bindingFMN
HgeneDPYDchr1:98348820chr12:104054109ENST00000370192-223793_79550.01026.0Nucleotide bindingFMN
HgeneDPYDchr1:98348820chr12:104054109ENST00000370192-223816_81750.01026.0Nucleotide bindingFMN
HgeneDPYDchr1:98348820chr12:104054109ENST00000370192-223668_67050.01026.0RegionSubstrate binding
HgeneDPYDchr1:98348820chr12:104054109ENST00000370192-223736_73750.01026.0RegionSubstrate binding
TgeneSTAB2chr1:98348820chr12:104054109ENST000003888871469108_148578.02552.0DomainEGF-like 1
TgeneSTAB2chr1:98348820chr12:104054109ENST000003888871469156_193578.02552.0DomainEGF-like 2
TgeneSTAB2chr1:98348820chr12:104054109ENST000003888871469195_236578.02552.0DomainEGF-like 3
TgeneSTAB2chr1:98348820chr12:104054109ENST000003888871469237_276578.02552.0DomainEGF-like 4
TgeneSTAB2chr1:98348820chr12:104054109ENST000003888871469322_362578.02552.0DomainEGF-like 5
TgeneSTAB2chr1:98348820chr12:104054109ENST000003888871469371_505578.02552.0DomainFAS1 1
TgeneSTAB2chr1:98348820chr12:104054109ENST000003888871469515_652578.02552.0DomainFAS1 2
TgeneSTAB2chr1:98348820chr12:104054109ENST00000388887146920_2458578.02552.0Topological domainExtracellular


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Fusion Gene Sequence for DPYD-STAB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000370192_ENST00000388887_TCGA-BH-A1EU-01A_DPYD_chr1_98348820_-_STAB2_chr12_104054109_length(transcript)=6564nt_BP=251nt
TTTCGACTCGCGCTCCGGCTGCTGTCACTTGGCTCTCTGGCTGGAGCTTGAGGACGCAAGGAGGGTTTGTCACTGGCAGACTCGAGACTG
TAGGCACTGCCATGGCCCCTGTGCTCAGTAAGGACTCGGCGGACATCGAGAGTATCCTGGCTTTAAATCCTCGAACACAAACTCATGCAA
CTCTGCGTTCCACTTCGGCCAAGAAATTAGACAAGAAACATTGGAAAAGAAATCCTGATAAGAACTGCTTTGGATCTCGGAAGCTTCTGG
AACTCGTCAGATACCACATTGTCCCATTTACCCAGCTTGAAGTGGCCACTCTCATCTCCACCCCTCACATCAGGAGCATGGCCAACCAGC
TCATACAGTTCAACACCACCGACAATGGACAGATTCTGGCAAATGATGTGGCAATGGAAGAAATTGAGATCACTGCCAAAAATGGCCGAA
TTTACACACTGACAGGAGTTCTCATTCCTCCCTCCATTGTCCCGATTCTGCCCCATCGATGTGATGAAACAAAGAGAGAGATGAAACTGG
GCACTTGTGTGAGCTGTTCTCTGGTGTACTGGAGCAGATGTCCTGCTAACTCTGAGCCCACAGCACTCTTCACACACAGATGTGTCTACA
GTGGCAGGTTTGGGAGCCTGAAGAGCGGCTGTGCCCGGTACTGCAATGCCACTGTGAAGATTCCAAAGTGCTGCAAAGGCTTCTATGGAC
CTGACTGCAACCAGTGTCCAGGAGGCTTCTCAAATCCATGCTCAGGAAATGGACAGTGTGCAGATAGCCTCGGCGGCAACGGGACATGCA
TTTGTGAGGAGGGCTTCCAAGGCTCCCAGTGTCAGTTCTGCTCTGATCCCAATAAATACGGACCTCGGTGTAACAAAAAATGCCTGTGCG
TTCACGGAACATGCAATAACAGGATAGACAGCGATGGGGCCTGCCTCACTGGCACATGCAGAGACGGCTCTGCCGGGAGACTCTGTGATA
AGCAGACCTCAGCCTGTGGGCCCTACGTGCAGTTCTGTCACATCCACGCCACCTGTGAATACAGCAATGGGACAGCCAGTTGTATTTGCA
AAGCAGGATATGAAGGAGATGGAACTCTGTGTTCTGAGATGGACCCTTGCACAGGACTAACTCCAGGAGGCTGTAGCCGCAATGCAGAAT
GCATCAAAACTGGCACGGGCACCCACACCTGCGTGTGTCAGCAGGGTTGGACAGGGAATGGGAGAGACTGCTCGGAGATCAACAACTGCC
TGCTGCCCAGTGCAGGCGGCTGCCACGACAACGCATCCTGTTTGTATGTGGGTCCCGGGCAGAATGAGTGTGAGTGCAAGAAAGGATTTC
GAGGAAATGGGATTGACTGTGAACCAATAACTTCATGCTTGGAACAAACCGGGAAATGTCATCCATTGGCAAGCTGTCAATCTACTTCGT
CTGGTGTCTGGAGCTGTGTTTGTCAAGAGGGCTATGAAGGAGATGGCTTTCTGTGCTATGGAAACGCAGCAGTGGAATTGTCATTTCTCT
CCGAAGCAGCTATATTTAACCGATGGATAAATAATGCTTCTCTACAACCCACACTGTCAGCCACCTCAAACCTCACTGTCCTCGTGCCTT
CCCAACAAGCTACTGAGGACATGGACCAGGATGAGAAAAGCTTCTGGTTGTCACAGAGCAATATTCCAGCCCTAATAAAGTACCATATGC
TACTAGGCACATACAGAGTGGCAGATCTGCAGACCCTGTCTTCTTCTGACATGTTGGCAACATCTTTGCAGGGCAACTTCCTTCACTTGG
CAAAGGTGGATGGGAATATCACAATTGAAGGGGCCTCCATTGTCGATGGGGACAACGCAGCCACAAATGGAGTGATACACATCATCAACA
AGGTGCTGGTCCCACAAAGACGTCTAACTGGCTCCTTACCAAACCTGCTCATGCGGCTGGAACAGATGCCTGACTATTCCATCTTCCGGG
GCTACATCATTCAATATAATCTGGCGAATGCAATTGAGGCTGCCGATGCCTACACAGTGTTTGCTCCAAACAACAATGCCATCGAGAATT
ACATCAGGGAGAAGAAAGTCTTGTCTCTAGAGGAGGACGTCCTCCGGTATCATGTGGTCCTGGAGGAGAAACTCCTGAAGAATGACCTGC
ACAATGGCATGCATCGTGAGACCATGCTGGGTTTCTCCTATTTCCTTAGCTTCTTTCTCCATAATGACCAGCTCTATGTAAATGAGGCTC
CAATAAACTACACCAATGTAGCCACTGATAAGGGAGTGATCCATGGCTTGGGAAAAGTTCTGGAAATTCAGAAGAACAGATGTGATAATA
ATGACACTACTATTATACGAGGAAGATGTAGGACATGCTCCTCAGAGCTGACCTGCCCATTCGGAACTAAATCTCTAGGTAATGAGAAGA
GGAGATGCATCTATACCTCCTATTTCATGGGAAGACGAACCCTGTTTATTGGGTGCCAGCCAAAATGTGTGAGAACCGTCATTACGAGAG
AATGCTGTGCCGGCTTCTTTGGCCCCCAATGCCAGCCCTGCCCAGGGAATGCCCAGAATGTCTGCTTTGGTAATGGCATCTGTTTGGATG
GAGTGAATGGCACAGGTGTGTGTGAGTGTGGGGAGGGCTTCAGCGGCACAGCCTGCGAGACCTGCACCGAGGGCAAGTACGGCATCCACT
GTGACCAAGCATGTTCTTGTGTCCATGGGAGATGCAACCAAGGACCCTTGGGAGATGGCTCCTGTGACTGTGATGTTGGCTGGCGAGGAG
TGCATTGTGACAATGCAACCACAGAAGACAACTGCAATGGGACATGCCATACCAGCGCCAACTGCCTCACCAACTCAGATGGTACAGCTT
CATGCAAGTGTGCAGCAGGATTCCAAGGAAACGGGACCATCTGCACAGCAATCAATGCCTGTGAGATCAGCAATGGAGGTTGCTCTGCCA
AGGCTGACTGTAAGAGAACCACCCCAGGAAGGCGAGTGTGCACGTGCAAAGCAGGCTACACGGGTGATGGCATTGTGTGCCTGGAAATCA
ACCCGTGTTTGGAGAACCATGGTGGCTGTGACAAGAATGCGGAGTGCACACAGACAGGACCCAACCAGGCTGCCTGTAACTGTTTGCCAG
CATACACTGGAGATGGAAAGGTCTGCACACTCATCAATGTCTGCTTAACTAAAAATGGCGGCTGTAGTGAATTTGCCATCTGCAACCACA
CTGGGCAAGTAGAAAGGACTTGTACTTGCAAGCCAAACTACATTGGAGATGGATTTACCTGCCGCGGCAGCATTTATCAGGAGCTTCCCA
AGAACCCGAAAACTTCCCAGTATTTCTTCCAGTTGCAGGAGCATTTCGTGAAAGATCTGGTCGGCCCAGGCCCCTTCACTGTTTTTGCAC
CTTTATCTGCAGCCTTTGATGAGGAAGCTCGGGTTAAAGACTGGGACAAATACGGTTTAATGCCCCAGGTTCTTCGGTACCATGTGGTCG
CCTGCCACCAGCTGCTTCTGGAAAACCTGAAATTGATCTCAAATGCTACTTCCCTCCAAGGAGAGCCAATAGTCATCTCCGTCTCTCAGA
GCACGGTGTATATAAACAATAAGGCTAAGATCATATCCAGTGATATCATCAGTACTAATGGGATTGTTCATATCATAGACAAATTGCTAT
CTCCCAAAAATTTGCTTATCACTCCCAAAGACAACTCTGGAAGAATTCTGCAAAATCTTACGACTTTGGCAACAAACAATGGCTACATCA
AATTTAGCAACTTAATACAGGACTCAGGTTTGCTGAGTGTCATCACCGATCCCATCCACACCCCAGTCACTCTCTTCTGGCCCACCGACC
AAGCCCTCCATGCCCTACCTGCTGAACAACAGGACTTCCTGTTCAACCAAGACAACAAGGACAAGCTGAAGGAGTATTTGAAGTTTCATG
TGATACGAGATGCCAAGGTTTTAGCTGTGGATCTTCCCACATCCACTGCCTGGAAGACCCTGCAAGGTTCAGAGCTGAGTGTGAAATGTG
GAGCTGGCAGGGACATCGGTGACCTCTTTCTGAATGGCCAAACCTGCAGAATTGTGCAGCGGGAGCTCTTGTTTGACCTGGGTGTGGCCT
ACGGCATTGACTGTCTGCTGATTGATCCCACCCTGGGGGGCCGCTGTGACACCTTTACTACTTTCGATGCCTCGGGGGAGTGTGGGAGCT
GTGTCAATACTCCCAGCTGCCCAAGGTGGAGTAAACCAAAGGGTGTGAAGCAGAAGTGTCTCTACAACCTGCCCTTCAAGAGGAACCTGG
AAGGCTGCCGGGAGCGGTGCAGCCTGGTGATACAGATCCCCAGGTGCTGCAAGGGCTACTTCGGGCGAGACTGTCAGGCCTGCCCTGGAG
GACCAGATGCCCCGTGTAATAACCGGGGTGTCTGCCTTGATCAGTACTCGGCCACCGGAGAGTGTAAATGCAACACCGGCTTCAATGGGA
CGGCGTGTGAGATGTGCTGGCCGGGGAGATTCGGGCCTGATTGTCTGCCCTGTGGCTGCTCAGACCACGGACAGTGCGATGATGGCATCA
CGGGCTCCGGGCAGTGCCTCTGTGAAACGGGGTGGACAGGCCCCTCGTGTGACACTCAGGCAGTTTTGCCTGCAGTGTGTACGCCTCCTT
GTTCTGCTCATGCCACCTGTAAGGAGAACAACACGTGTGAGTGTAACCTGGATTATGAAGGTGACGGAATCACATGCACAGTTGTGGATT
TCTGCAAACAGGACAACGGGGGCTGTGCAAAGGTGGCCAGATGCTCCCAGAAGGGCACGAAGGTCTCCTGCAGCTGCCAGAAGGGATACA
AAGGGGACGGGCACAGCTGCACAGAGATAGACCCCTGTGCAGACGGCCTTAACGGAGGGTGTCACGAGCACGCCACCTGTAAGATGACAG
GCCCGGGCAAGCACAAGTGTGAGTGTAAAAGTCACTATGTCGGAGATGGGCTGAACTGTGAGCCGGAGCAGCTGCCCATTGACCGCTGCT
TACAGGACAATGGGCAGTGCCATGCAGACGCCAAATGTGTCGACCTCCACTTCCAGGATACCACTGTTGGGGTGTTCCATCTACGCTCCC
CACTGGGCCAGTATAAGCTGACCTTTGACAAAGCCAGAGAGGCCTGTGCCAACGAAGCTGCGACCATGGCAACCTACAACCAGCTCTCCT
ATGCCCAGAAGGCCAAGTACCACCTGTGCTCAGCAGGCTGGCTGGAGACCGGGCGGGTTGCCTACCCCACAGCCTTCGCCTCCCAGAACT
GTGGCTCTGGTGTGGTTGGGATAGTGGACTATGGACCTAGACCCAACAAGAGTGAAATGTGGGATGTCTTCTGCTATCGGATGAAAGATG
TGAACTGCACCTGCAAGGTGGGCTATGTGGGAGATGGCTTCTCATGCAGTGGGAACCTGCTGCAGGTCCTGATGTCCTTCCCCTCACTCA
CAAACTTCCTGACGGAAGTGCTGGCCTATTCCAACAGCTCAGCTCGAGGCCGTGCATTTCTAGAACACCTGACTGACCTGTCCATCCGCG
GCACCCTCTTTGTGCCACAGAACAGTGGGCTGGGGGAGAATGAGACCTTGTCTGGGCGGGACATCGAGCACCACCTCGCCAATGTCAGCA
TGTTTTTCTACAATGACCTTGTCAATGGCACCACCCTGCAAACGAGGCTGGGAAGCAAGCTGCTCATCACTGCCAGCCAGGACCCACTCC
AACCGACGGAGACCAGGTTTGTTGATGGAAGAGCCATTCTGCAGTGGGACATCTTTGCCTCCAATGGGATCATTCATGTCATTTCCAGGC
CTTTAAAAGCACCCCCTGCCCCCGTGACCTTGACCCACACTGGCTTGGGAGCAGGGATCTTCTTTGCCATCATCCTGGTGACTGGGGCTG
TTGCCTTGGCTGCTTACTCCTACTTTCGGATAAACCGGAGAACAATCGGCTTCCAGCATTTTGAGTCGGAAGAGGACATTAATGTTGCAG
CTCTTGGCAAGCAGCAGCCTGAGAATATCTCGAACCCCTTGTATGAGAGCACAACCTCAGCTCCCCCAGAACCTTCCTACGACCCCTTCA
CGGACTCTGAAGAACGGCAGCTTGAGGGCAATGACCCCTTGAGGACACTGTGAGGGCCTGGACGGGAGATGCCAGCCATCACTCACTGCC
ACCTGGGCCATCAACTGTGAATTCTCAGCACCAGTTGCCTTTTAGGAACGTAAAGTCCTTTAAGCACTCAGAAGCCATACCTCATCTCTC
TGGCTGATCTGGGGGTTGTTTCTGTGGGTGAGAGATGTGTTGCTGTGCCCACCCAGTACAGCTTCCTCCTCTGACCCTTTGGCTCTTCTT
CCTTTGTACTCTTCAGCTGGCACCTGCTCCATTCTGCCCTACATGATGGGTAACTGTGATCTTTCTTCCCTGTTAGATTGTAAGCCTCCG

>In-frame_ENST00000370192_ENST00000388887_TCGA-BH-A1EU-01A_DPYD_chr1_98348820_-_STAB2_chr12_104054109_length(amino acids)=2041AA_start in transcript=47_stop in transcript=6172
MRTQGGFVTGRLETVGTAMAPVLSKDSADIESILALNPRTQTHATLRSTSAKKLDKKHWKRNPDKNCFGSRKLLELVRYHIVPFTQLEVA
TLISTPHIRSMANQLIQFNTTDNGQILANDVAMEEIEITAKNGRIYTLTGVLIPPSIVPILPHRCDETKREMKLGTCVSCSLVYWSRCPA
NSEPTALFTHRCVYSGRFGSLKSGCARYCNATVKIPKCCKGFYGPDCNQCPGGFSNPCSGNGQCADSLGGNGTCICEEGFQGSQCQFCSD
PNKYGPRCNKKCLCVHGTCNNRIDSDGACLTGTCRDGSAGRLCDKQTSACGPYVQFCHIHATCEYSNGTASCICKAGYEGDGTLCSEMDP
CTGLTPGGCSRNAECIKTGTGTHTCVCQQGWTGNGRDCSEINNCLLPSAGGCHDNASCLYVGPGQNECECKKGFRGNGIDCEPITSCLEQ
TGKCHPLASCQSTSSGVWSCVCQEGYEGDGFLCYGNAAVELSFLSEAAIFNRWINNASLQPTLSATSNLTVLVPSQQATEDMDQDEKSFW
LSQSNIPALIKYHMLLGTYRVADLQTLSSSDMLATSLQGNFLHLAKVDGNITIEGASIVDGDNAATNGVIHIINKVLVPQRRLTGSLPNL
LMRLEQMPDYSIFRGYIIQYNLANAIEAADAYTVFAPNNNAIENYIREKKVLSLEEDVLRYHVVLEEKLLKNDLHNGMHRETMLGFSYFL
SFFLHNDQLYVNEAPINYTNVATDKGVIHGLGKVLEIQKNRCDNNDTTIIRGRCRTCSSELTCPFGTKSLGNEKRRCIYTSYFMGRRTLF
IGCQPKCVRTVITRECCAGFFGPQCQPCPGNAQNVCFGNGICLDGVNGTGVCECGEGFSGTACETCTEGKYGIHCDQACSCVHGRCNQGP
LGDGSCDCDVGWRGVHCDNATTEDNCNGTCHTSANCLTNSDGTASCKCAAGFQGNGTICTAINACEISNGGCSAKADCKRTTPGRRVCTC
KAGYTGDGIVCLEINPCLENHGGCDKNAECTQTGPNQAACNCLPAYTGDGKVCTLINVCLTKNGGCSEFAICNHTGQVERTCTCKPNYIG
DGFTCRGSIYQELPKNPKTSQYFFQLQEHFVKDLVGPGPFTVFAPLSAAFDEEARVKDWDKYGLMPQVLRYHVVACHQLLLENLKLISNA
TSLQGEPIVISVSQSTVYINNKAKIISSDIISTNGIVHIIDKLLSPKNLLITPKDNSGRILQNLTTLATNNGYIKFSNLIQDSGLLSVIT
DPIHTPVTLFWPTDQALHALPAEQQDFLFNQDNKDKLKEYLKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTC
RIVQRELLFDLGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPFKRNLEGCRERCSLVIQIPRC
CKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNTGFNGTACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPS
CDTQAVLPAVCTPPCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGHSCTEIDPCADG
LNGGCHEHATCKMTGPGKHKCECKSHYVGDGLNCEPEQLPIDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFDKAREAC
ANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKSEMWDVFCYRMKDVNCTCKVGYVGDGFSC
SGNLLQVLMSFPSLTNFLTEVLAYSNSSARGRAFLEHLTDLSIRGTLFVPQNSGLGENETLSGRDIEHHLANVSMFFYNDLVNGTTLQTR
LGSKLLITASQDPLQPTETRFVDGRAILQWDIFASNGIIHVISRPLKAPPAPVTLTHTGLGAGIFFAIILVTGAVALAAYSYFRINRRTI

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>In-frame_ENST00000306031_ENST00000388887_TCGA-BH-A1EU-01A_DPYD_chr1_98348820_-_STAB2_chr12_104054109_length(transcript)=6590nt_BP=277nt
CGCGCCGCCGGCCCTAGTCTGCCTGTTTTCGACTCGCGCTCCGGCTGCTGTCACTTGGCTCTCTGGCTGGAGCTTGAGGACGCAAGGAGG
GTTTGTCACTGGCAGACTCGAGACTGTAGGCACTGCCATGGCCCCTGTGCTCAGTAAGGACTCGGCGGACATCGAGAGTATCCTGGCTTT
AAATCCTCGAACACAAACTCATGCAACTCTGCGTTCCACTTCGGCCAAGAAATTAGACAAGAAACATTGGAAAAGAAATCCTGATAAGAA
CTGCTTTGGATCTCGGAAGCTTCTGGAACTCGTCAGATACCACATTGTCCCATTTACCCAGCTTGAAGTGGCCACTCTCATCTCCACCCC
TCACATCAGGAGCATGGCCAACCAGCTCATACAGTTCAACACCACCGACAATGGACAGATTCTGGCAAATGATGTGGCAATGGAAGAAAT
TGAGATCACTGCCAAAAATGGCCGAATTTACACACTGACAGGAGTTCTCATTCCTCCCTCCATTGTCCCGATTCTGCCCCATCGATGTGA
TGAAACAAAGAGAGAGATGAAACTGGGCACTTGTGTGAGCTGTTCTCTGGTGTACTGGAGCAGATGTCCTGCTAACTCTGAGCCCACAGC
ACTCTTCACACACAGATGTGTCTACAGTGGCAGGTTTGGGAGCCTGAAGAGCGGCTGTGCCCGGTACTGCAATGCCACTGTGAAGATTCC
AAAGTGCTGCAAAGGCTTCTATGGACCTGACTGCAACCAGTGTCCAGGAGGCTTCTCAAATCCATGCTCAGGAAATGGACAGTGTGCAGA
TAGCCTCGGCGGCAACGGGACATGCATTTGTGAGGAGGGCTTCCAAGGCTCCCAGTGTCAGTTCTGCTCTGATCCCAATAAATACGGACC
TCGGTGTAACAAAAAATGCCTGTGCGTTCACGGAACATGCAATAACAGGATAGACAGCGATGGGGCCTGCCTCACTGGCACATGCAGAGA
CGGCTCTGCCGGGAGACTCTGTGATAAGCAGACCTCAGCCTGTGGGCCCTACGTGCAGTTCTGTCACATCCACGCCACCTGTGAATACAG
CAATGGGACAGCCAGTTGTATTTGCAAAGCAGGATATGAAGGAGATGGAACTCTGTGTTCTGAGATGGACCCTTGCACAGGACTAACTCC
AGGAGGCTGTAGCCGCAATGCAGAATGCATCAAAACTGGCACGGGCACCCACACCTGCGTGTGTCAGCAGGGTTGGACAGGGAATGGGAG
AGACTGCTCGGAGATCAACAACTGCCTGCTGCCCAGTGCAGGCGGCTGCCACGACAACGCATCCTGTTTGTATGTGGGTCCCGGGCAGAA
TGAGTGTGAGTGCAAGAAAGGATTTCGAGGAAATGGGATTGACTGTGAACCAATAACTTCATGCTTGGAACAAACCGGGAAATGTCATCC
ATTGGCAAGCTGTCAATCTACTTCGTCTGGTGTCTGGAGCTGTGTTTGTCAAGAGGGCTATGAAGGAGATGGCTTTCTGTGCTATGGAAA
CGCAGCAGTGGAATTGTCATTTCTCTCCGAAGCAGCTATATTTAACCGATGGATAAATAATGCTTCTCTACAACCCACACTGTCAGCCAC
CTCAAACCTCACTGTCCTCGTGCCTTCCCAACAAGCTACTGAGGACATGGACCAGGATGAGAAAAGCTTCTGGTTGTCACAGAGCAATAT
TCCAGCCCTAATAAAGTACCATATGCTACTAGGCACATACAGAGTGGCAGATCTGCAGACCCTGTCTTCTTCTGACATGTTGGCAACATC
TTTGCAGGGCAACTTCCTTCACTTGGCAAAGGTGGATGGGAATATCACAATTGAAGGGGCCTCCATTGTCGATGGGGACAACGCAGCCAC
AAATGGAGTGATACACATCATCAACAAGGTGCTGGTCCCACAAAGACGTCTAACTGGCTCCTTACCAAACCTGCTCATGCGGCTGGAACA
GATGCCTGACTATTCCATCTTCCGGGGCTACATCATTCAATATAATCTGGCGAATGCAATTGAGGCTGCCGATGCCTACACAGTGTTTGC
TCCAAACAACAATGCCATCGAGAATTACATCAGGGAGAAGAAAGTCTTGTCTCTAGAGGAGGACGTCCTCCGGTATCATGTGGTCCTGGA
GGAGAAACTCCTGAAGAATGACCTGCACAATGGCATGCATCGTGAGACCATGCTGGGTTTCTCCTATTTCCTTAGCTTCTTTCTCCATAA
TGACCAGCTCTATGTAAATGAGGCTCCAATAAACTACACCAATGTAGCCACTGATAAGGGAGTGATCCATGGCTTGGGAAAAGTTCTGGA
AATTCAGAAGAACAGATGTGATAATAATGACACTACTATTATACGAGGAAGATGTAGGACATGCTCCTCAGAGCTGACCTGCCCATTCGG
AACTAAATCTCTAGGTAATGAGAAGAGGAGATGCATCTATACCTCCTATTTCATGGGAAGACGAACCCTGTTTATTGGGTGCCAGCCAAA
ATGTGTGAGAACCGTCATTACGAGAGAATGCTGTGCCGGCTTCTTTGGCCCCCAATGCCAGCCCTGCCCAGGGAATGCCCAGAATGTCTG
CTTTGGTAATGGCATCTGTTTGGATGGAGTGAATGGCACAGGTGTGTGTGAGTGTGGGGAGGGCTTCAGCGGCACAGCCTGCGAGACCTG
CACCGAGGGCAAGTACGGCATCCACTGTGACCAAGCATGTTCTTGTGTCCATGGGAGATGCAACCAAGGACCCTTGGGAGATGGCTCCTG
TGACTGTGATGTTGGCTGGCGAGGAGTGCATTGTGACAATGCAACCACAGAAGACAACTGCAATGGGACATGCCATACCAGCGCCAACTG
CCTCACCAACTCAGATGGTACAGCTTCATGCAAGTGTGCAGCAGGATTCCAAGGAAACGGGACCATCTGCACAGCAATCAATGCCTGTGA
GATCAGCAATGGAGGTTGCTCTGCCAAGGCTGACTGTAAGAGAACCACCCCAGGAAGGCGAGTGTGCACGTGCAAAGCAGGCTACACGGG
TGATGGCATTGTGTGCCTGGAAATCAACCCGTGTTTGGAGAACCATGGTGGCTGTGACAAGAATGCGGAGTGCACACAGACAGGACCCAA
CCAGGCTGCCTGTAACTGTTTGCCAGCATACACTGGAGATGGAAAGGTCTGCACACTCATCAATGTCTGCTTAACTAAAAATGGCGGCTG
TAGTGAATTTGCCATCTGCAACCACACTGGGCAAGTAGAAAGGACTTGTACTTGCAAGCCAAACTACATTGGAGATGGATTTACCTGCCG
CGGCAGCATTTATCAGGAGCTTCCCAAGAACCCGAAAACTTCCCAGTATTTCTTCCAGTTGCAGGAGCATTTCGTGAAAGATCTGGTCGG
CCCAGGCCCCTTCACTGTTTTTGCACCTTTATCTGCAGCCTTTGATGAGGAAGCTCGGGTTAAAGACTGGGACAAATACGGTTTAATGCC
CCAGGTTCTTCGGTACCATGTGGTCGCCTGCCACCAGCTGCTTCTGGAAAACCTGAAATTGATCTCAAATGCTACTTCCCTCCAAGGAGA
GCCAATAGTCATCTCCGTCTCTCAGAGCACGGTGTATATAAACAATAAGGCTAAGATCATATCCAGTGATATCATCAGTACTAATGGGAT
TGTTCATATCATAGACAAATTGCTATCTCCCAAAAATTTGCTTATCACTCCCAAAGACAACTCTGGAAGAATTCTGCAAAATCTTACGAC
TTTGGCAACAAACAATGGCTACATCAAATTTAGCAACTTAATACAGGACTCAGGTTTGCTGAGTGTCATCACCGATCCCATCCACACCCC
AGTCACTCTCTTCTGGCCCACCGACCAAGCCCTCCATGCCCTACCTGCTGAACAACAGGACTTCCTGTTCAACCAAGACAACAAGGACAA
GCTGAAGGAGTATTTGAAGTTTCATGTGATACGAGATGCCAAGGTTTTAGCTGTGGATCTTCCCACATCCACTGCCTGGAAGACCCTGCA
AGGTTCAGAGCTGAGTGTGAAATGTGGAGCTGGCAGGGACATCGGTGACCTCTTTCTGAATGGCCAAACCTGCAGAATTGTGCAGCGGGA
GCTCTTGTTTGACCTGGGTGTGGCCTACGGCATTGACTGTCTGCTGATTGATCCCACCCTGGGGGGCCGCTGTGACACCTTTACTACTTT
CGATGCCTCGGGGGAGTGTGGGAGCTGTGTCAATACTCCCAGCTGCCCAAGGTGGAGTAAACCAAAGGGTGTGAAGCAGAAGTGTCTCTA
CAACCTGCCCTTCAAGAGGAACCTGGAAGGCTGCCGGGAGCGGTGCAGCCTGGTGATACAGATCCCCAGGTGCTGCAAGGGCTACTTCGG
GCGAGACTGTCAGGCCTGCCCTGGAGGACCAGATGCCCCGTGTAATAACCGGGGTGTCTGCCTTGATCAGTACTCGGCCACCGGAGAGTG
TAAATGCAACACCGGCTTCAATGGGACGGCGTGTGAGATGTGCTGGCCGGGGAGATTCGGGCCTGATTGTCTGCCCTGTGGCTGCTCAGA
CCACGGACAGTGCGATGATGGCATCACGGGCTCCGGGCAGTGCCTCTGTGAAACGGGGTGGACAGGCCCCTCGTGTGACACTCAGGCAGT
TTTGCCTGCAGTGTGTACGCCTCCTTGTTCTGCTCATGCCACCTGTAAGGAGAACAACACGTGTGAGTGTAACCTGGATTATGAAGGTGA
CGGAATCACATGCACAGTTGTGGATTTCTGCAAACAGGACAACGGGGGCTGTGCAAAGGTGGCCAGATGCTCCCAGAAGGGCACGAAGGT
CTCCTGCAGCTGCCAGAAGGGATACAAAGGGGACGGGCACAGCTGCACAGAGATAGACCCCTGTGCAGACGGCCTTAACGGAGGGTGTCA
CGAGCACGCCACCTGTAAGATGACAGGCCCGGGCAAGCACAAGTGTGAGTGTAAAAGTCACTATGTCGGAGATGGGCTGAACTGTGAGCC
GGAGCAGCTGCCCATTGACCGCTGCTTACAGGACAATGGGCAGTGCCATGCAGACGCCAAATGTGTCGACCTCCACTTCCAGGATACCAC
TGTTGGGGTGTTCCATCTACGCTCCCCACTGGGCCAGTATAAGCTGACCTTTGACAAAGCCAGAGAGGCCTGTGCCAACGAAGCTGCGAC
CATGGCAACCTACAACCAGCTCTCCTATGCCCAGAAGGCCAAGTACCACCTGTGCTCAGCAGGCTGGCTGGAGACCGGGCGGGTTGCCTA
CCCCACAGCCTTCGCCTCCCAGAACTGTGGCTCTGGTGTGGTTGGGATAGTGGACTATGGACCTAGACCCAACAAGAGTGAAATGTGGGA
TGTCTTCTGCTATCGGATGAAAGATGTGAACTGCACCTGCAAGGTGGGCTATGTGGGAGATGGCTTCTCATGCAGTGGGAACCTGCTGCA
GGTCCTGATGTCCTTCCCCTCACTCACAAACTTCCTGACGGAAGTGCTGGCCTATTCCAACAGCTCAGCTCGAGGCCGTGCATTTCTAGA
ACACCTGACTGACCTGTCCATCCGCGGCACCCTCTTTGTGCCACAGAACAGTGGGCTGGGGGAGAATGAGACCTTGTCTGGGCGGGACAT
CGAGCACCACCTCGCCAATGTCAGCATGTTTTTCTACAATGACCTTGTCAATGGCACCACCCTGCAAACGAGGCTGGGAAGCAAGCTGCT
CATCACTGCCAGCCAGGACCCACTCCAACCGACGGAGACCAGGTTTGTTGATGGAAGAGCCATTCTGCAGTGGGACATCTTTGCCTCCAA
TGGGATCATTCATGTCATTTCCAGGCCTTTAAAAGCACCCCCTGCCCCCGTGACCTTGACCCACACTGGCTTGGGAGCAGGGATCTTCTT
TGCCATCATCCTGGTGACTGGGGCTGTTGCCTTGGCTGCTTACTCCTACTTTCGGATAAACCGGAGAACAATCGGCTTCCAGCATTTTGA
GTCGGAAGAGGACATTAATGTTGCAGCTCTTGGCAAGCAGCAGCCTGAGAATATCTCGAACCCCTTGTATGAGAGCACAACCTCAGCTCC
CCCAGAACCTTCCTACGACCCCTTCACGGACTCTGAAGAACGGCAGCTTGAGGGCAATGACCCCTTGAGGACACTGTGAGGGCCTGGACG
GGAGATGCCAGCCATCACTCACTGCCACCTGGGCCATCAACTGTGAATTCTCAGCACCAGTTGCCTTTTAGGAACGTAAAGTCCTTTAAG
CACTCAGAAGCCATACCTCATCTCTCTGGCTGATCTGGGGGTTGTTTCTGTGGGTGAGAGATGTGTTGCTGTGCCCACCCAGTACAGCTT
CCTCCTCTGACCCTTTGGCTCTTCTTCCTTTGTACTCTTCAGCTGGCACCTGCTCCATTCTGCCCTACATGATGGGTAACTGTGATCTTT
CTTCCCTGTTAGATTGTAAGCCTCCGTCTTTGTATCCCAGCCCCTAGCCCAGTGCCTGACACAGGAACTGTGCACAATAAAGGTTTATGG

>In-frame_ENST00000306031_ENST00000388887_TCGA-BH-A1EU-01A_DPYD_chr1_98348820_-_STAB2_chr12_104054109_length(amino acids)=2058AA_start in transcript=22_stop in transcript=6198
MFSTRAPAAVTWLSGWSLRTQGGFVTGRLETVGTAMAPVLSKDSADIESILALNPRTQTHATLRSTSAKKLDKKHWKRNPDKNCFGSRKL
LELVRYHIVPFTQLEVATLISTPHIRSMANQLIQFNTTDNGQILANDVAMEEIEITAKNGRIYTLTGVLIPPSIVPILPHRCDETKREMK
LGTCVSCSLVYWSRCPANSEPTALFTHRCVYSGRFGSLKSGCARYCNATVKIPKCCKGFYGPDCNQCPGGFSNPCSGNGQCADSLGGNGT
CICEEGFQGSQCQFCSDPNKYGPRCNKKCLCVHGTCNNRIDSDGACLTGTCRDGSAGRLCDKQTSACGPYVQFCHIHATCEYSNGTASCI
CKAGYEGDGTLCSEMDPCTGLTPGGCSRNAECIKTGTGTHTCVCQQGWTGNGRDCSEINNCLLPSAGGCHDNASCLYVGPGQNECECKKG
FRGNGIDCEPITSCLEQTGKCHPLASCQSTSSGVWSCVCQEGYEGDGFLCYGNAAVELSFLSEAAIFNRWINNASLQPTLSATSNLTVLV
PSQQATEDMDQDEKSFWLSQSNIPALIKYHMLLGTYRVADLQTLSSSDMLATSLQGNFLHLAKVDGNITIEGASIVDGDNAATNGVIHII
NKVLVPQRRLTGSLPNLLMRLEQMPDYSIFRGYIIQYNLANAIEAADAYTVFAPNNNAIENYIREKKVLSLEEDVLRYHVVLEEKLLKND
LHNGMHRETMLGFSYFLSFFLHNDQLYVNEAPINYTNVATDKGVIHGLGKVLEIQKNRCDNNDTTIIRGRCRTCSSELTCPFGTKSLGNE
KRRCIYTSYFMGRRTLFIGCQPKCVRTVITRECCAGFFGPQCQPCPGNAQNVCFGNGICLDGVNGTGVCECGEGFSGTACETCTEGKYGI
HCDQACSCVHGRCNQGPLGDGSCDCDVGWRGVHCDNATTEDNCNGTCHTSANCLTNSDGTASCKCAAGFQGNGTICTAINACEISNGGCS
AKADCKRTTPGRRVCTCKAGYTGDGIVCLEINPCLENHGGCDKNAECTQTGPNQAACNCLPAYTGDGKVCTLINVCLTKNGGCSEFAICN
HTGQVERTCTCKPNYIGDGFTCRGSIYQELPKNPKTSQYFFQLQEHFVKDLVGPGPFTVFAPLSAAFDEEARVKDWDKYGLMPQVLRYHV
VACHQLLLENLKLISNATSLQGEPIVISVSQSTVYINNKAKIISSDIISTNGIVHIIDKLLSPKNLLITPKDNSGRILQNLTTLATNNGY
IKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAEQQDFLFNQDNKDKLKEYLKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVK
CGAGRDIGDLFLNGQTCRIVQRELLFDLGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYNLPFKRN
LEGCRERCSLVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNTGFNGTACEMCWPGRFGPDCLPCGCSDHGQCDDG
ITGSGQCLCETGWTGPSCDTQAVLPAVCTPPCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCSQKGTKVSCSCQKG
YKGDGHSCTEIDPCADGLNGGCHEHATCKMTGPGKHKCECKSHYVGDGLNCEPEQLPIDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLR
SPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPNKSEMWDVFCYRMK
DVNCTCKVGYVGDGFSCSGNLLQVLMSFPSLTNFLTEVLAYSNSSARGRAFLEHLTDLSIRGTLFVPQNSGLGENETLSGRDIEHHLANV
SMFFYNDLVNGTTLQTRLGSKLLITASQDPLQPTETRFVDGRAILQWDIFASNGIIHVISRPLKAPPAPVTLTHTGLGAGIFFAIILVTG

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Top

Fusion Gene PPI Analysis for DPYD-STAB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneSTAB2chr1:98348820chr12:104054109ENST0000038888714692504_2514578.02552.0TMSB4X


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for DPYD-STAB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for DPYD-STAB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDPYDC1959620Dihydropyrimidine Dehydrogenase Deficiency7CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneDPYDC0009402Colorectal Carcinoma5CTD_human
HgeneDPYDC0009404Colorectal Neoplasms5CTD_human
HgeneDPYDC0024623Malignant neoplasm of stomach3CTD_human
HgeneDPYDC0038356Stomach Neoplasms3CTD_human
HgeneDPYDC1708349Hereditary Diffuse Gastric Cancer3CTD_human
HgeneDPYDC0030297Pancreatic Neoplasm2CTD_human
HgeneDPYDC0034139Purine-Pyrimidine Metabolism, Inborn Errors2CTD_human
HgeneDPYDC0036341Schizophrenia2CTD_human
HgeneDPYDC0346647Malignant neoplasm of pancreas2CTD_human
HgeneDPYDC1510586Autism Spectrum Disorders2CTD_human
HgeneDPYDC3495551Dihydropyrimidinuria2CTD_human
HgeneDPYDC43045781p21.3 microdeletion syndrome2ORPHANET
HgeneDPYDC0004352Autistic Disorder1CTD_human
HgeneDPYDC0006142Malignant neoplasm of breast1CTD_human
HgeneDPYDC0007102Malignant tumor of colon1CTD_human
HgeneDPYDC0009375Colonic Neoplasms1CTD_human
HgeneDPYDC0018671Head and Neck Neoplasms1CTD_human
HgeneDPYDC0018675Head Neoplasms1CTD_human
HgeneDPYDC0023012Language Delay1CTD_human
HgeneDPYDC0023014Language Development Disorders1CTD_human
HgeneDPYDC0024121Lung Neoplasms1CTD_human
HgeneDPYDC0027533Neck Neoplasms1CTD_human
HgeneDPYDC0027627Neoplasm Metastasis1CTD_human
HgeneDPYDC0027765nervous system disorder1CTD_human
HgeneDPYDC0027947Neutropenia1CTD_human
HgeneDPYDC0028754Obesity1CTD_human
HgeneDPYDC0241210Speech Delay1CTD_human
HgeneDPYDC0242379Malignant neoplasm of lung1CTD_human
HgeneDPYDC0270612Leukoencephalopathy1CTD_human
HgeneDPYDC0278996Malignant Head and Neck Neoplasm1CTD_human
HgeneDPYDC0454655Semantic-Pragmatic Disorder1CTD_human
HgeneDPYDC0678222Breast Carcinoma1CTD_human
HgeneDPYDC0746787Cancer of Neck1CTD_human
HgeneDPYDC0751177Cancer of Head1CTD_human
HgeneDPYDC0751257Auditory Processing Disorder, Central1CTD_human
HgeneDPYDC0887900Upper Aerodigestive Tract Neoplasms1CTD_human
HgeneDPYDC1257931Mammary Neoplasms, Human1CTD_human
HgeneDPYDC1458155Mammary Neoplasms1CTD_human
HgeneDPYDC1858991Childhood Ataxia with Central Nervous System Hypomyelinization1CTD_human
HgeneDPYDC2239176Liver carcinoma1CTD_human
HgeneDPYDC4704874Mammary Carcinoma, Human1CTD_human
HgeneDPYDC4721453Peripheral Nervous System Diseases1CTD_human
TgeneSTAB2C0033578Prostatic Neoplasms1CTD_human
TgeneSTAB2C0376358Malignant neoplasm of prostate1CTD_human
TgeneSTAB2C2239176Liver carcinoma1CTD_human