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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DROSHA-TERT (FusionGDB2 ID:24151)

Fusion Gene Summary for DROSHA-TERT

check button Fusion gene summary
Fusion gene informationFusion gene name: DROSHA-TERT
Fusion gene ID: 24151
HgeneTgene
Gene symbol

DROSHA

TERT

Gene ID

29102

7015

Gene namedrosha ribonuclease IIItelomerase reverse transcriptase
SynonymsETOHI2|HSA242976|RANSE3L|RN3|RNASE3L|RNASENCMM9|DKCA2|DKCB4|EST2|PFBMFT1|TCS1|TP2|TRT|hEST2|hTRT
Cytomap

5p13.3

5p15.33

Type of geneprotein-codingprotein-coding
Descriptionribonuclease 3RNase IIIdrosha, double-stranded RNA-specific endoribonucleasenuclear RNase III Droshap241putative protein p241 which interacts with transcription factor Sp1putative ribonuclease IIIribonuclease type III, nucleartelomerase reverse transcriptasetelomerase catalytic subunittelomerase-associated protein 2
Modification date2020031320200329
UniProtAcc

Q9NRR4

.
Ensembl transtripts involved in fusion geneENST00000511367, ENST00000442743, 
ENST00000344624, ENST00000513349, 
ENST00000504361, 		ENST00000310581, 
ENST00000296820, ENST00000334602, 
ENST00000508104, ENST00000522877, 
Fusion gene scores* DoF score7 X 7 X 4=19622 X 7 X 15=2310
# samples 731
** MAII scorelog2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(31/2310*10)=-2.89755273102918
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DROSHA [Title/Abstract] AND TERT [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDROSHA(31421379)-TERT(1282739), # samples:3
Anticipated loss of major functional domain due to fusion event.DROSHA-TERT seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
DROSHA-TERT seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DROSHA-TERT seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDROSHA

GO:0031053

primary miRNA processing

14508493|15574589

HgeneDROSHA

GO:0050829

defense response to Gram-negative bacterium

20180804

HgeneDROSHA

GO:0050830

defense response to Gram-positive bacterium

20180804

TgeneTERT

GO:0001172

transcription, RNA-templated

19701182

TgeneTERT

GO:0006278

RNA-dependent DNA biosynthetic process

9398860

TgeneTERT

GO:0007004

telomere maintenance via telomerase

9443919|16043710|17940095|19701182|21531765|29695869

TgeneTERT

GO:0007005

mitochondrion organization

21937513

TgeneTERT

GO:0010629

negative regulation of gene expression

11927518

TgeneTERT

GO:0022616

DNA strand elongation

16043710

TgeneTERT

GO:0030422

production of siRNA involved in RNA interference

19701182

TgeneTERT

GO:0031647

regulation of protein stability

24415760|26194824

TgeneTERT

GO:0032092

positive regulation of protein binding

24415760

TgeneTERT

GO:0051000

positive regulation of nitric-oxide synthase activity

11927518

TgeneTERT

GO:0070200

establishment of protein localization to telomere

25589350

TgeneTERT

GO:0071897

DNA biosynthetic process

9398860|19701182

TgeneTERT

GO:1903704

negative regulation of production of siRNA involved in RNA interference

19701182

TgeneTERT

GO:1904751

positive regulation of protein localization to nucleolus

24415760

TgeneTERT

GO:2000773

negative regulation of cellular senescence

11927518


check buttonFusion gene breakpoints across DROSHA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TERT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-FW-A5DX-01ADROSHAchr5

31421379

-TERTchr5

1282739

-
ChimerDB4SKCMTCGA-FW-A5DX-01ADROSHAchr5

31421379

-TERTchr5

1282739

-
ChimerDB4SKCMTCGA-FW-A5DX-01ADROSHAchr5

31421379

-TERTchr5

1282739

-


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Fusion Gene ORF analysis for DROSHA-TERT

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000511367ENST00000310581DROSHAchr5

31421379

-TERTchr5

1282739

-
In-frameENST00000511367ENST00000296820DROSHAchr5

31421379

-TERTchr5

1282739

-
Frame-shiftENST00000511367ENST00000334602DROSHAchr5

31421379

-TERTchr5

1282739

-
Frame-shiftENST00000511367ENST00000508104DROSHAchr5

31421379

-TERTchr5

1282739

-
5CDS-intronENST00000511367ENST00000522877DROSHAchr5

31421379

-TERTchr5

1282739

-
Frame-shiftENST00000442743ENST00000310581DROSHAchr5

31421379

-TERTchr5

1282739

-
In-frameENST00000442743ENST00000296820DROSHAchr5

31421379

-TERTchr5

1282739

-
Frame-shiftENST00000442743ENST00000334602DROSHAchr5

31421379

-TERTchr5

1282739

-
Frame-shiftENST00000442743ENST00000508104DROSHAchr5

31421379

-TERTchr5

1282739

-
5CDS-intronENST00000442743ENST00000522877DROSHAchr5

31421379

-TERTchr5

1282739

-
Frame-shiftENST00000344624ENST00000310581DROSHAchr5

31421379

-TERTchr5

1282739

-
In-frameENST00000344624ENST00000296820DROSHAchr5

31421379

-TERTchr5

1282739

-
Frame-shiftENST00000344624ENST00000334602DROSHAchr5

31421379

-TERTchr5

1282739

-
Frame-shiftENST00000344624ENST00000508104DROSHAchr5

31421379

-TERTchr5

1282739

-
5CDS-intronENST00000344624ENST00000522877DROSHAchr5

31421379

-TERTchr5

1282739

-
In-frameENST00000513349ENST00000310581DROSHAchr5

31421379

-TERTchr5

1282739

-
Frame-shiftENST00000513349ENST00000296820DROSHAchr5

31421379

-TERTchr5

1282739

-
In-frameENST00000513349ENST00000334602DROSHAchr5

31421379

-TERTchr5

1282739

-
In-frameENST00000513349ENST00000508104DROSHAchr5

31421379

-TERTchr5

1282739

-
5CDS-intronENST00000513349ENST00000522877DROSHAchr5

31421379

-TERTchr5

1282739

-
intron-3CDSENST00000504361ENST00000310581DROSHAchr5

31421379

-TERTchr5

1282739

-
intron-3CDSENST00000504361ENST00000296820DROSHAchr5

31421379

-TERTchr5

1282739

-
intron-3CDSENST00000504361ENST00000334602DROSHAchr5

31421379

-TERTchr5

1282739

-
intron-3CDSENST00000504361ENST00000508104DROSHAchr5

31421379

-TERTchr5

1282739

-
intron-intronENST00000504361ENST00000522877DROSHAchr5

31421379

-TERTchr5

1282739

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000511367DROSHAchr531421379-ENST00000296820TERTchr51282739-5968377024538411198
ENST00000442743DROSHAchr531421379-ENST00000296820TERTchr51282739-565934614735321161
ENST00000344624DROSHAchr531421379-ENST00000296820TERTchr51282739-577035724736431198
ENST00000513349DROSHAchr531421379-ENST00000310581TERTchr51282739-6170378336938541161
ENST00000513349DROSHAchr531421379-ENST00000334602TERTchr51282739-5420378336938541161
ENST00000513349DROSHAchr531421379-ENST00000508104TERTchr51282739-4696378336938541161

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000511367ENST00000296820DROSHAchr531421379-TERTchr51282739-0.0010843460.9989157
ENST00000442743ENST00000296820DROSHAchr531421379-TERTchr51282739-0.0014328850.9985671
ENST00000344624ENST00000296820DROSHAchr531421379-TERTchr51282739-0.0009331020.9990669
ENST00000513349ENST00000310581DROSHAchr531421379-TERTchr51282739-0.0017563250.9982437
ENST00000513349ENST00000334602DROSHAchr531421379-TERTchr51282739-0.0020672170.9979328
ENST00000513349ENST00000508104DROSHAchr531421379-TERTchr51282739-0.0014536180.99854636

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Fusion Genomic Features for DROSHA-TERT


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DROSHA-TERT


check button Go to

FGviewer for the breakpoints of chr5:31421379-chr5:1282739

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DROSHA

Q9NRR4

.
FUNCTION: Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. {ECO:0000269|PubMed:10948199, ECO:0000269|PubMed:14508493, ECO:0000269|PubMed:15531877, ECO:0000269|PubMed:15565168, ECO:0000269|PubMed:15574589, ECO:0000269|PubMed:15589161, ECO:0000269|PubMed:16751099, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:17159994, ECO:0000269|PubMed:26027739, ECO:0000269|PubMed:26748718}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDROSHAchr5:31421379chr5:1282739ENST00000344624-27331_2121175.01375.0Compositional biasNote=Pro-rich
HgeneDROSHAchr5:31421379chr5:1282739ENST00000344624-2733219_3161175.01375.0Compositional biasNote=Arg-rich
HgeneDROSHAchr5:31421379chr5:1282739ENST00000442743-26321_2121138.01338.0Compositional biasNote=Pro-rich
HgeneDROSHAchr5:31421379chr5:1282739ENST00000442743-2632219_3161138.01338.0Compositional biasNote=Arg-rich
HgeneDROSHAchr5:31421379chr5:1282739ENST00000511367-29351_2121175.01375.0Compositional biasNote=Pro-rich
HgeneDROSHAchr5:31421379chr5:1282739ENST00000511367-2935219_3161175.01375.0Compositional biasNote=Arg-rich
HgeneDROSHAchr5:31421379chr5:1282739ENST00000513349-29351_2121138.01338.0Compositional biasNote=Pro-rich
HgeneDROSHAchr5:31421379chr5:1282739ENST00000513349-2935219_3161138.01338.0Compositional biasNote=Arg-rich
HgeneDROSHAchr5:31421379chr5:1282739ENST00000344624-2733876_10561175.01375.0DomainNote=RNase III 1
HgeneDROSHAchr5:31421379chr5:1282739ENST00000442743-2632876_10561138.01338.0DomainNote=RNase III 1
HgeneDROSHAchr5:31421379chr5:1282739ENST00000511367-2935876_10561175.01375.0DomainNote=RNase III 1
HgeneDROSHAchr5:31421379chr5:1282739ENST00000513349-2935876_10561138.01338.0DomainNote=RNase III 1
TgeneTERTchr5:31421379chr5:1282739ENST00000296820114605_935524.3333333333334445.6666666666667DomainReverse transcriptase
TgeneTERTchr5:31421379chr5:1282739ENST00000310581116605_935524.33333333333341133.0DomainReverse transcriptase
TgeneTERTchr5:31421379chr5:1282739ENST00000334602115605_935524.33333333333341070.0DomainReverse transcriptase
TgeneTERTchr5:31421379chr5:1282739ENST0000050810418605_935524.3333333333334808.0DomainReverse transcriptase
TgeneTERTchr5:31421379chr5:1282739ENST00000296820114914_928524.3333333333334445.6666666666667RegionNote=Required for oligomerization
TgeneTERTchr5:31421379chr5:1282739ENST00000296820114936_1132524.3333333333334445.6666666666667RegionNote=CTE
TgeneTERTchr5:31421379chr5:1282739ENST00000310581116914_928524.33333333333341133.0RegionNote=Required for oligomerization
TgeneTERTchr5:31421379chr5:1282739ENST00000310581116936_1132524.33333333333341133.0RegionNote=CTE
TgeneTERTchr5:31421379chr5:1282739ENST00000334602115914_928524.33333333333341070.0RegionNote=Required for oligomerization
TgeneTERTchr5:31421379chr5:1282739ENST00000334602115936_1132524.33333333333341070.0RegionNote=CTE
TgeneTERTchr5:31421379chr5:1282739ENST0000050810418914_928524.3333333333334808.0RegionNote=Required for oligomerization
TgeneTERTchr5:31421379chr5:1282739ENST0000050810418936_1132524.3333333333334808.0RegionNote=CTE

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDROSHAchr5:31421379chr5:1282739ENST00000344624-27331107_12331175.01375.0DomainNote=RNase III 2
HgeneDROSHAchr5:31421379chr5:1282739ENST00000344624-27331260_13341175.01375.0DomainNote=DRBM
HgeneDROSHAchr5:31421379chr5:1282739ENST00000442743-26321107_12331138.01338.0DomainNote=RNase III 2
HgeneDROSHAchr5:31421379chr5:1282739ENST00000442743-26321260_13341138.01338.0DomainNote=DRBM
HgeneDROSHAchr5:31421379chr5:1282739ENST00000511367-29351107_12331175.01375.0DomainNote=RNase III 2
HgeneDROSHAchr5:31421379chr5:1282739ENST00000511367-29351260_13341175.01375.0DomainNote=DRBM
HgeneDROSHAchr5:31421379chr5:1282739ENST00000513349-29351107_12331138.01338.0DomainNote=RNase III 2
HgeneDROSHAchr5:31421379chr5:1282739ENST00000513349-29351260_13341138.01338.0DomainNote=DRBM
TgeneTERTchr5:31421379chr5:1282739ENST00000296820114222_240524.3333333333334445.6666666666667MotifNote=Bipartite nuclear localization signal
TgeneTERTchr5:31421379chr5:1282739ENST00000296820114328_333524.3333333333334445.6666666666667MotifTFLY%3B involved in RNA binding
TgeneTERTchr5:31421379chr5:1282739ENST00000310581116222_240524.33333333333341133.0MotifNote=Bipartite nuclear localization signal
TgeneTERTchr5:31421379chr5:1282739ENST00000310581116328_333524.33333333333341133.0MotifTFLY%3B involved in RNA binding
TgeneTERTchr5:31421379chr5:1282739ENST00000334602115222_240524.33333333333341070.0MotifNote=Bipartite nuclear localization signal
TgeneTERTchr5:31421379chr5:1282739ENST00000334602115328_333524.33333333333341070.0MotifTFLY%3B involved in RNA binding
TgeneTERTchr5:31421379chr5:1282739ENST0000050810418222_240524.3333333333334808.0MotifNote=Bipartite nuclear localization signal
TgeneTERTchr5:31421379chr5:1282739ENST0000050810418328_333524.3333333333334808.0MotifTFLY%3B involved in RNA binding
TgeneTERTchr5:31421379chr5:1282739ENST000002968201141_230524.3333333333334445.6666666666667RegionNote=RNA-interacting domain 1
TgeneTERTchr5:31421379chr5:1282739ENST00000296820114231_324524.3333333333334445.6666666666667RegionNote=Linker
TgeneTERTchr5:31421379chr5:1282739ENST00000296820114301_538524.3333333333334445.6666666666667RegionNote=Required for oligomerization
TgeneTERTchr5:31421379chr5:1282739ENST00000296820114325_550524.3333333333334445.6666666666667RegionNote=RNA-interacting domain 2
TgeneTERTchr5:31421379chr5:1282739ENST00000296820114376_521524.3333333333334445.6666666666667RegionNote=QFP motif
TgeneTERTchr5:31421379chr5:1282739ENST00000296820114397_417524.3333333333334445.6666666666667RegionNote=CP motif
TgeneTERTchr5:31421379chr5:1282739ENST0000029682011458_197524.3333333333334445.6666666666667RegionNote=GQ motif
TgeneTERTchr5:31421379chr5:1282739ENST000003105811161_230524.33333333333341133.0RegionNote=RNA-interacting domain 1
TgeneTERTchr5:31421379chr5:1282739ENST00000310581116231_324524.33333333333341133.0RegionNote=Linker
TgeneTERTchr5:31421379chr5:1282739ENST00000310581116301_538524.33333333333341133.0RegionNote=Required for oligomerization
TgeneTERTchr5:31421379chr5:1282739ENST00000310581116325_550524.33333333333341133.0RegionNote=RNA-interacting domain 2
TgeneTERTchr5:31421379chr5:1282739ENST00000310581116376_521524.33333333333341133.0RegionNote=QFP motif
TgeneTERTchr5:31421379chr5:1282739ENST00000310581116397_417524.33333333333341133.0RegionNote=CP motif
TgeneTERTchr5:31421379chr5:1282739ENST0000031058111658_197524.33333333333341133.0RegionNote=GQ motif
TgeneTERTchr5:31421379chr5:1282739ENST000003346021151_230524.33333333333341070.0RegionNote=RNA-interacting domain 1
TgeneTERTchr5:31421379chr5:1282739ENST00000334602115231_324524.33333333333341070.0RegionNote=Linker
TgeneTERTchr5:31421379chr5:1282739ENST00000334602115301_538524.33333333333341070.0RegionNote=Required for oligomerization
TgeneTERTchr5:31421379chr5:1282739ENST00000334602115325_550524.33333333333341070.0RegionNote=RNA-interacting domain 2
TgeneTERTchr5:31421379chr5:1282739ENST00000334602115376_521524.33333333333341070.0RegionNote=QFP motif
TgeneTERTchr5:31421379chr5:1282739ENST00000334602115397_417524.33333333333341070.0RegionNote=CP motif
TgeneTERTchr5:31421379chr5:1282739ENST0000033460211558_197524.33333333333341070.0RegionNote=GQ motif
TgeneTERTchr5:31421379chr5:1282739ENST00000508104181_230524.3333333333334808.0RegionNote=RNA-interacting domain 1
TgeneTERTchr5:31421379chr5:1282739ENST0000050810418231_324524.3333333333334808.0RegionNote=Linker
TgeneTERTchr5:31421379chr5:1282739ENST0000050810418301_538524.3333333333334808.0RegionNote=Required for oligomerization
TgeneTERTchr5:31421379chr5:1282739ENST0000050810418325_550524.3333333333334808.0RegionNote=RNA-interacting domain 2
TgeneTERTchr5:31421379chr5:1282739ENST0000050810418376_521524.3333333333334808.0RegionNote=QFP motif
TgeneTERTchr5:31421379chr5:1282739ENST0000050810418397_417524.3333333333334808.0RegionNote=CP motif
TgeneTERTchr5:31421379chr5:1282739ENST000005081041858_197524.3333333333334808.0RegionNote=GQ motif


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Fusion Gene Sequence for DROSHA-TERT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000511367_ENST00000296820_TCGA-FW-A5DX-01A_DROSHA_chr5_31421379_-_TERT_chr5_1282739_length(transcript)=5968nt_BP=3770nt
CTGTCTTGGTACCTGCGGTAGTAGCCTGGCTTTGCTCTGACGGCGATCTCGCGGCCCGAGAGCCTTTTATAGGTTGCTTTTCCCGGGGAT
GTGAAGGATACAGAAATGACTGTGAATCAACCCATATCATCAAGGAGCTGATAATCTAGTGGAAGAGTTAGACGTGTGCATACTTCACTA
TGATATGAGGCAGTCTCTGAGCTTATATTCTCTGTGGAAGATGTGACATATCCAGGCGGAACATCATGATGCAGGGAAACACATGTCACA
GAATGTCGTTCCACCCGGGACGAGGGTGTCCCCGAGGACGAGGAGGACATGGAGCCAGACCCTCAGCACCATCCTTTAGGCCCCAAAATC
TGAGGCTGCTTCACCCTCAGCAGCCTCCTGTGCAATATCAATATGAACCTCCAAGTGCCCCTTCCACCACTTTCTCAAACTCTCCAGCCC
CCAATTTTCTCCCTCCACGACCAGACTTTGTACCCTTCCCCCCACCCATGCCTCCGTCAGCGCAAGGCCCTCTTCCCCCCTGCCCAATCA
GGCCGCCTTTCCCCAACCACCAGATGAGGCACCCCTTCCCAGTTCCTCCTTGTTTTCCTCCCATGCCACCACCAATGCCTTGTCCTAATA
ACCCCCCAGTCCCTGGGGCACCTCCTGGACAAGGCACTTTCCCCTTCATGATGCCCCCTCCCTCCATGCCTCATCCCCCGCCCCCTCCAG
TCATGCCGCAGCAGGTTAATTATCAGTACCCTCCGGGCTATTCTCACCACAACTTCCCACCTCCCAGTTTTAATAGTTTCCAGAACAACC
CTAGTTCTTTCCTGCCCAGTGCTAATAACAGCAGTAGTCCTCATTTCAGACATCTCCCTCCATACCCACTCCCAAAGGCTCCCAGTGAGA
GAAGGTCCCCAGAAAGGCTGAAACACTATGATGACCACAGGCACCGAGATCACAGTCATGGGCGAGGTGAGAGGCATCGGTCCCTGGATC
GGCGGGAGCGAGGCCGCAGTCCCGACAGGAGAAGACAAGACAGCCGGTACAGATCTGATTATGACCGAGGGAGAACACCATCTCGCCACC
GCAGCTACGAACGGAGCAGAGAGCGAGAACGGGAGAGACACAGGCATCGAGACAACCGAAGATCACCATCTCTGGAAAGGTCCTACAAAA
AAGAGTATAAGAGATCTGGAAGGAGTTACGGTTTATCGGTTGTTCCTGAACCTGCTGGATGCACACCAGAATTACCTGGGGAGATTATTA
AAAATACAGATTCTTGGGCCCCACCCCTGGAGATTGTGAATCATCGCTCCCCAAGTAGGGAGAAGAAGAGAGCTCGTTGGGAGGAAGAAA
AAGACCGTTGGAGTGACAACCAGAGTTCTGGCAAAGACAAGAACTATACCTCAATCAAGGAAAAAGAGCCCGAGGAGACCATGCCTGACA
AGAATGAGGAGGAAGAAGAAGAACTTCTTAAGCCTGTGTGGATTCGATGCACTCATTCAGAAAACTACTACTCCAGTGACCCCATGGATC
AGGTGGGAGATTCTACAGTGGTTGGAACGAGTAGGCTTCGTGACTTATATGACAAATTTGAGGAGGAGTTGGGGAGCAGGCAAGAAAAGG
CCAAAGCTGCTCGGCCTCCGTGGGAACCTCCAAAGACGAAGCTCGATGAAGATTTAGAGAGTTCCAGTGAATCCGAGTGTGAGTCTGATG
AGGACAGCACCTGTTCTAGCAGCTCAGACTCTGAAGTTTTTGACGTTATTGCAGAAATCAAACGCAAAAAGGCCCACCCTGACCGACTTC
ATGATGAACTTTGGTACAACGATCCAGGCCAGATGAATGATGGACCACTCTGCAAATGCAGCGCAAAGGCAAGACGCACAGGAATTAGGC
ACAGCATTTATCCTGGAGAAGAGGCCATCAAGCCCTGTCGTCCTATGACCAACAATGCTGGCAGACTTTTCCACTACCGGATCACAGTCT
CCCCGCCTACGAACTTTTTAACTGACAGGCCAACTGTTATAGAATACGATGATCACGAGTATATCTTTGAAGGATTTTCTATGTTTGCAC
ATGCCCCCCTGACCAATATTCCACTGTGTAAAGTAATTAGATTCAACATAGACTACACGATTCATTTCATTGAAGAGATGATGCCGGAGA
ATTTTTGTGTGAAAGGGCTTGAACTCTTTTCACTGTTCCTATTCAGAGATATTTTGGAATTATATGACTGGAATCTTAAAGGTCCTTTGT
TTGAAGACAGCCCTCCCTGCTGCCCAAGATTTCATTTCATGCCACGTTTTGTAAGATTTCTTCCAGATGGAGGAAAGGAAGTGCTGTCCA
TGCACCAGATTCTCCTGTACTTGTTAAGGTGCAGCAAAGCCCTGGTGCCTGAGGAGGAGATTGCCAATATGCTTCAGTGGGAGGAGCTGG
AGTGGCAGAAATATGCAGAAGAATGCAAAGGCATGATTGTTACCAACCCTGGGACGAAACCAAGCTCTGTCCGTATCGATCAACTGGATC
GTGAACAGTTCAACCCCGATGTGATTACTTTTCCGATTATCGTCCACTTTGGGATACGCCCTGCACAGTTGAGTTATGCAGGAGACCCAC
AGTACCAAAAACTGTGGAAGAGTTATGTGAAACTTCGCCACCTCCTAGCAAATAGTCCCAAAGTCAAACAAACTGACAAACAGAAGCTGG
CACAGAGGGAGGAAGCCCTCCAAAAAATACGGCAGAAGAATACAATGAGACGAGAAGTAACGGTGGAGCTAAGTAGCCAAGGATTCTGGA
AAACTGGCATCCGTTCTGATGTCTGTCAGCATGCAATGATGCTACCTGTTCTGACCCATCATATCCGCTACCACCAATGCCTAATGCATT
TGGACAAGTTGATAGGATATACTTTCCAAGATCGTTGTCTGTTGCAGCTGGCCATGACTCATCCAAGTCATCATTTAAATTTTGGAATGA
ATCCTGATCATGCCAGGAATTCATTATCTAACTGTGGAATTCGGCAGCCCAAATACGGAGACAGAAAAGTTCATCACATGCACATGCGGA
AGAAAGGGATTAACACCTTGATAAATATCATGTCACGCCTTGGCCAAGATGACCCAACTCCCTCGAGGATTAACCACAATGAACGGTTGG
AATTCCTGGGTGATGCTGTTGTTGAATTTCTGACCAGCGTCCATTTGTACTATTTGTTTCCTAGTCTGGAAGAAGGAGGATTAGCAACCT
ATCGGACTGCCATTGTTCAGAATCAGCACCTTGCCATGCTAGCAAAGAAACTTGAACTGGATCGATTTATGCTGTATGCTCACGGGCCTG
ACCTTTGTAGAGAATCGGACCTTCGACATGCAATGGCCAATTGTTTTGAAGCGTTAATAGGAGCTGTTTACTTGGAGGGAAGCCTGGAGG
AAGCCAAGCAGTTATTTGGACGCTTGCTCTTTAATGATCCGGACCTGCGCGAAGTCTGGCTCAATTATCCTCTCCACCCACTCCAACTAC
AAGAGCCAAATACTGATCGACAACTTATTGAAACTTCTCCAGTTCTACAAAAACTTACTGAGTTTGAAGAAGCAATTGGAGTAATTTTTA
CTCATGTTCGACTTCTGGCAAGGGCATTCACATTGAGAACTGTGGGATTTAACCATCTGACCCTAGGCCACAATCAGAGAATGGAATTCC
TAGGTGACTCCATAATGCAACTGGTAGCCACAGAGTACTTATTCATTCATTTCCCAGATCATCATGAAGGACACTTAACTGGGTTGGCTG
TGTTCCGGCCGCAGAGCACCGTCTGCGTGAGGAGATCCTGGCCAAGTTCCTGCACTGGCTGATGAGTGTGTACGTCGTCGAGCTGCTCAG
GTCTTTCTTTTATGTCACGGAGACCACGTTTCAAAAGAACAGGCTCTTTTTCTACCGGAAGAGTGTCTGGAGCAAGTTGCAAAGCATTGG
AATCAGACAGCACTTGAAGAGGGTGCAGCTGCGGGAGCTGTCGGAAGCAGAGGTCAGGCAGCATCGGGAAGCCAGGCCCGCCCTGCTGAC
GTCCAGACTCCGCTTCATCCCCAAGCCTGACGGGCTGCGGCCGATTGTGAACATGGACTACGTCGTGGGAGCCAGAACGTTCCGCAGAGA
AAAGAGGGCCGAGCGTCTCACCTCGAGGGTGAAGGCACTGTTCAGCGTGCTCAACTACGAGCGGGCGCGGCGCCCCGGCCTCCTGGGCGC
CTCTGTGCTGGGCCTGGACGATATCCACAGGGCCTGGCGCACCTTCGTGCTGCGTGTGCGGGCCCAGGACCCGCCGCCTGAGCTGTACTT
TGTCAAGGTGGATGTGACGGGCGCGTACGACACCATCCCCCAGGACAGGCTCACGGAGGTCATCGCCAGCATCATCAAACCCCAGAACAC
GTACTGCGTGCGTCGGTATGCCGTGGTCCAGAAGGCCGCCCATGGGCACGTCCGCAAGGCCTTCAAGAGCCACGTCCTACGTCCAGTGCC
AGGGGATCCCGCAGGGCTCCATCCTCTCCACGCTGCTCTGCAGCCTGTGCTACGGCGACATGGAGAACAAGCTGTTTGCGGGGATTCGGC
GGGACGGGCTGCTCCTGCGTTTGGTGGATGATTTCTTGTTGGTGACACCTCACCTCACCCACGCGAAAACCTTCCTCAGGACCCTGGTCC
GAGGTGTCCCTGAGTATGGCTGCGTGGTGAACTTGCGGAAGACAGTGGTGAACTTCCCTGTAGAAGACGAGGCCCTGGGTGGCACGGCTT
TTGTTCAGATGCCGGCCCACGGCCTATTCCCCTGGTGCGGCCTGCTGCTGGATACCCGGACCCTGGAGGTGCAGAGCGACTACTCCAGCT
ATGCCCGGACCTCCATCAGAGCCAGTCTCACCTTCAACCGCGGCTTCAAGGCTGGGAGGAACATGCGTCGCAAACTCTTTGGGGTCTTGC
GGCTGAAGTGTCACAGCCTGTTTCTGGATTTGCAGGTGAACAGCCTCCAGACGGTGTGCACCAACATCTACAAGATCCTCCTGCTGCAGG
CGTACAGGTTTCACGCATGTGTGCTGCAGCTCCCATTTCATCAGCAAGTTTGGAAGAACCCCACATTTTTCCTGCGCGTCATCTCTGACA
CGGCCTCCCTCTGCTACTCCATCCTGAAAGCCAAGAACGCAGGGATGTCGCTGGGGGCCAAGGGCGCCGCCGGCCCTCTGCCCTCCGAGG
CCGTGCAGTGGCTGTGCCACCAAGCATTCCTGCTCAAGCTGACTCGACACCGTGTCACCTACGTGCCACTCCTGGGGTCACTCAGGACAG
CCCAGACGCAGCTGAGTCGGAAGCTCCCGGGGACGACGCTGACTGCCCTGGAGGCCGCAGCCAACCCGGCACTGCCCTCAGACTTCAAGA
CCATCCTGGACTGATGGCCACCCGCCCACAGCCAGGCCGAGAGCAGACACCAGCAGCCCTGTCACGCCGGGCTCTACGTCCCAGGGAGGG
AGGGGCGGCCCACACCCAGGCCCGCACCGCTGGGAGTCTGAGGCCTGAGTGAGTGTTTGGCCGAGGCCTGCATGTCCGGCTGAAGGCTGA
GTGTCCGGCTGAGGCCTGAGCGAGTGTCCAGCCAAGGGCTGAGTGTCCAGCACACCTGCCGTCTTCACTTCCCCACAGGCTGGCGCTCGG
CTCCACCCCAGGGCCAGCTTTTCCTCACCAGGAGCCCGGCTTCCACTCCCCACATAGGAATAGTCCATCCCCAGATTCGCCATTGTTCAC
CCCTCGCCCTGCCCTCCTTTGCCTTCCACCCCCACCATCCAGGTGGAGACCCTGAGAAGGACCCTGGGAGCTCTGGGAATTTGGAGTGAC
CAAAGGTGTGCCCTGTACACAGGCGAGGACCCTGCACCTGGATGGGGGTCCCTGTGGGTCAAATTGGGGGGAGGTGCTGTGGGAGTAAAA

>In-frame_ENST00000511367_ENST00000296820_TCGA-FW-A5DX-01A_DROSHA_chr5_31421379_-_TERT_chr5_1282739_length(amino acids)=1198AA_start in transcript=245_stop in transcript=3841
MMQGNTCHRMSFHPGRGCPRGRGGHGARPSAPSFRPQNLRLLHPQQPPVQYQYEPPSAPSTTFSNSPAPNFLPPRPDFVPFPPPMPPSAQ
GPLPPCPIRPPFPNHQMRHPFPVPPCFPPMPPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHPPPPPVMPQQVNYQYPPGYSHHNFPPP
SFNSFQNNPSSFLPSANNSSSPHFRHLPPYPLPKAPSERRSPERLKHYDDHRHRDHSHGRGERHRSLDRRERGRSPDRRRQDSRYRSDYD
RGRTPSRHRSYERSRERERERHRHRDNRRSPSLERSYKKEYKRSGRSYGLSVVPEPAGCTPELPGEIIKNTDSWAPPLEIVNHRSPSREK
KRARWEEEKDRWSDNQSSGKDKNYTSIKEKEPEETMPDKNEEEEEELLKPVWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKFEE
ELGSRQEKAKAARPPWEPPKTKLDEDLESSSESECESDEDSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSA
KARRTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIEYDDHEYIFEGFSMFAHAPLTNIPLCKVIRFNIDYTIH
FIEEMMPENFCVKGLELFSLFLFRDILELYDWNLKGPLFEDSPPCCPRFHFMPRFVRFLPDGGKEVLSMHQILLYLLRCSKALVPEEEIA
NMLQWEELEWQKYAEECKGMIVTNPGTKPSSVRIDQLDREQFNPDVITFPIIVHFGIRPAQLSYAGDPQYQKLWKSYVKLRHLLANSPKV
KQTDKQKLAQREEALQKIRQKNTMRREVTVELSSQGFWKTGIRSDVCQHAMMLPVLTHHIRYHQCLMHLDKLIGYTFQDRCLLQLAMTHP
SHHLNFGMNPDHARNSLSNCGIRQPKYGDRKVHHMHMRKKGINTLINIMSRLGQDDPTPSRINHNERLEFLGDAVVEFLTSVHLYYLFPS
LEEGGLATYRTAIVQNQHLAMLAKKLELDRFMLYAHGPDLCRESDLRHAMANCFEALIGAVYLEGSLEEAKQLFGRLLFNDPDLREVWLN
YPLHPLQLQEPNTDRQLIETSPVLQKLTEFEEAIGVIFTHVRLLARAFTLRTVGFNHLTLGHNQRMEFLGDSIMQLVATEYLFIHFPDHH

--------------------------------------------------------------
>In-frame_ENST00000442743_ENST00000296820_TCGA-FW-A5DX-01A_DROSHA_chr5_31421379_-_TERT_chr5_1282739_length(transcript)=5659nt_BP=3461nt
GAGCTTATATTCTCTGTGGAAGATGTGACATATCCAGGCGGAACATCATGATGCAGGGAAACACATGTCACAGAATGTCGTTCCACCCGG
GACGAGGGTGTCCCCGAGGACGAGGAGGACATGGAGCCAGACCCTCAGCACCATCCTTTAGGCCCCAAAATCTGAGGCTGCTTCACCCTC
AGCAGCCTCCTGTGCAATATCAATATGAACCTCCAAGTGCCCCTTCCACCACTTTCTCAAACTCTCCAGCCCCCAATTTTCTCCCTCCAC
GACCAGACTTTGTACCCTTCCCCCCACCCATGCCTCCGTCAGCGCAAGGCCCTCTTCCCCCCTGCCCAATCAGGCCGCCTTTCCCCAACC
ACCAGATGAGGCACCCCTTCCCAGTTCCTCCTTGTTTTCCTCCCATGCCACCACCAATGCCTTGTCCTAATAACCCCCCAGTCCCTGGGG
CACCTCCTGGACAAGGCACTTTCCCCTTCATGATGCCCCCTCCCTCCATGCCTCATCCCCCGCCCCCTCCAGTCATGCCGCAGCAGGTTA
ATTATCAGTACCCTCCGGGCTATTCTCACCACAACTTCCCACCTCCCAGTTTTAATAGTTTCCAGAACAACCCTAGTTCTTTCCTGCCCA
GTGCTAATAACAGCAGTAGTCCTCATTTCAGACATCTCCCTCCATACCCACTCCCAAAGGCTCCCAGTGAGAGAAGGTCCCCAGAAAGGC
TGAAACACTATGATGACCACAGGCACCGAGATCACAGTCATGGGCGAGGTGAGAGGCATCGGTCCCTGGATCGGCGGGAGCGAGGCCGCA
GTCCCGACAGGAGAAGACAAGACAGCCGGTACAGATCTGATTATGACCGAGGGAGAACACCATCTCGCCACCGCAGCTACGAACGGAGCA
GAGAGCGAGAACGGGAGAGACACAGGCATCGAGACAACCGAAGATCACCATCTCTGGAAAGGTCCTACAAAAAAGAGTATAAGAGATCTG
GAAGTCGCTCCCCAAGTAGGGAGAAGAAGAGAGCTCGTTGGGAGGAAGAAAAAGACCGTTGGAGTGACAACCAGAGTTCTGGCAAAGACA
AGAACTATACCTCAATCAAGGAAAAAGAGCCCGAGGAGACCATGCCTGACAAGAATGAGGAGGAAGAAGAAGAACTTCTTAAGCCTGTGT
GGATTCGATGCACTCATTCAGAAAACTACTACTCCAGTGACCCCATGGATCAGGTGGGAGATTCTACAGTGGTTGGAACGAGTAGGCTTC
GTGACTTATATGACAAATTTGAGGAGGAGTTGGGGAGCAGGCAAGAAAAGGCCAAAGCTGCTCGGCCTCCGTGGGAACCTCCAAAGACGA
AGCTCGATGAAGATTTAGAGAGTTCCAGTGAATCCGAGTGTGAGTCTGATGAGGACAGCACCTGTTCTAGCAGCTCAGACTCTGAAGTTT
TTGACGTTATTGCAGAAATCAAACGCAAAAAGGCCCACCCTGACCGACTTCATGATGAACTTTGGTACAACGATCCAGGCCAGATGAATG
ATGGACCACTCTGCAAATGCAGCGCAAAGGCAAGACGCACAGGAATTAGGCACAGCATTTATCCTGGAGAAGAGGCCATCAAGCCCTGTC
GTCCTATGACCAACAATGCTGGCAGACTTTTCCACTACCGGATCACAGTCTCCCCGCCTACGAACTTTTTAACTGACAGGCCAACTGTTA
TAGAATACGATGATCACGAGTATATCTTTGAAGGATTTTCTATGTTTGCACATGCCCCCCTGACCAATATTCCACTGTGTAAAGTAATTA
GATTCAACATAGACTACACGATTCATTTCATTGAAGAGATGATGCCGGAGAATTTTTGTGTGAAAGGGCTTGAACTCTTTTCACTGTTCC
TATTCAGAGATATTTTGGAATTATATGACTGGAATCTTAAAGGTCCTTTGTTTGAAGACAGCCCTCCCTGCTGCCCAAGATTTCATTTCA
TGCCACGTTTTGTAAGATTTCTTCCAGATGGAGGAAAGGAAGTGCTGTCCATGCACCAGATTCTCCTGTACTTGTTAAGGTGCAGCAAAG
CCCTGGTGCCTGAGGAGGAGATTGCCAATATGCTTCAGTGGGAGGAGCTGGAGTGGCAGAAATATGCAGAAGAATGCAAAGGCATGATTG
TTACCAACCCTGGGACGAAACCAAGCTCTGTCCGTATCGATCAACTGGATCGTGAACAGTTCAACCCCGATGTGATTACTTTTCCGATTA
TCGTCCACTTTGGGATACGCCCTGCACAGTTGAGTTATGCAGGAGACCCACAGTACCAAAAACTGTGGAAGAGTTATGTGAAACTTCGCC
ACCTCCTAGCAAATAGTCCCAAAGTCAAACAAACTGACAAACAGAAGCTGGCACAGAGGGAGGAAGCCCTCCAAAAAATACGGCAGAAGA
ATACAATGAGACGAGAAGTAACGGTGGAGCTAAGTAGCCAAGGATTCTGGAAAACTGGCATCCGTTCTGATGTCTGTCAGCATGCAATGA
TGCTACCTGTTCTGACCCATCATATCCGCTACCACCAATGCCTAATGCATTTGGACAAGTTGATAGGATATACTTTCCAAGATCGTTGTC
TGTTGCAGCTGGCCATGACTCATCCAAGTCATCATTTAAATTTTGGAATGAATCCTGATCATGCCAGGAATTCATTATCTAACTGTGGAA
TTCGGCAGCCCAAATACGGAGACAGAAAAGTTCATCACATGCACATGCGGAAGAAAGGGATTAACACCTTGATAAATATCATGTCACGCC
TTGGCCAAGATGACCCAACTCCCTCGAGGATTAACCACAATGAACGGTTGGAATTCCTGGGTGATGCTGTTGTTGAATTTCTGACCAGCG
TCCATTTGTACTATTTGTTTCCTAGTCTGGAAGAAGGAGGATTAGCAACCTATCGGACTGCCATTGTTCAGAATCAGCACCTTGCCATGC
TAGCAAAGAAACTTGAACTGGATCGATTTATGCTGTATGCTCACGGGCCTGACCTTTGTAGAGAATCGGACCTTCGACATGCAATGGCCA
ATTGTTTTGAAGCGTTAATAGGAGCTGTTTACTTGGAGGGAAGCCTGGAGGAAGCCAAGCAGTTATTTGGACGCTTGCTCTTTAATGATC
CGGACCTGCGCGAAGTCTGGCTCAATTATCCTCTCCACCCACTCCAACTACAAGAGCCAAATACTGATCGACAACTTATTGAAACTTCTC
CAGTTCTACAAAAACTTACTGAGTTTGAAGAAGCAATTGGAGTAATTTTTACTCATGTTCGACTTCTGGCAAGGGCATTCACATTGAGAA
CTGTGGGATTTAACCATCTGACCCTAGGCCACAATCAGAGAATGGAATTCCTAGGTGACTCCATAATGCAACTGGTAGCCACAGAGTACT
TATTCATTCATTTCCCAGATCATCATGAAGGACACTTAACTGGGTTGGCTGTGTTCCGGCCGCAGAGCACCGTCTGCGTGAGGAGATCCT
GGCCAAGTTCCTGCACTGGCTGATGAGTGTGTACGTCGTCGAGCTGCTCAGGTCTTTCTTTTATGTCACGGAGACCACGTTTCAAAAGAA
CAGGCTCTTTTTCTACCGGAAGAGTGTCTGGAGCAAGTTGCAAAGCATTGGAATCAGACAGCACTTGAAGAGGGTGCAGCTGCGGGAGCT
GTCGGAAGCAGAGGTCAGGCAGCATCGGGAAGCCAGGCCCGCCCTGCTGACGTCCAGACTCCGCTTCATCCCCAAGCCTGACGGGCTGCG
GCCGATTGTGAACATGGACTACGTCGTGGGAGCCAGAACGTTCCGCAGAGAAAAGAGGGCCGAGCGTCTCACCTCGAGGGTGAAGGCACT
GTTCAGCGTGCTCAACTACGAGCGGGCGCGGCGCCCCGGCCTCCTGGGCGCCTCTGTGCTGGGCCTGGACGATATCCACAGGGCCTGGCG
CACCTTCGTGCTGCGTGTGCGGGCCCAGGACCCGCCGCCTGAGCTGTACTTTGTCAAGGTGGATGTGACGGGCGCGTACGACACCATCCC
CCAGGACAGGCTCACGGAGGTCATCGCCAGCATCATCAAACCCCAGAACACGTACTGCGTGCGTCGGTATGCCGTGGTCCAGAAGGCCGC
CCATGGGCACGTCCGCAAGGCCTTCAAGAGCCACGTCCTACGTCCAGTGCCAGGGGATCCCGCAGGGCTCCATCCTCTCCACGCTGCTCT
GCAGCCTGTGCTACGGCGACATGGAGAACAAGCTGTTTGCGGGGATTCGGCGGGACGGGCTGCTCCTGCGTTTGGTGGATGATTTCTTGT
TGGTGACACCTCACCTCACCCACGCGAAAACCTTCCTCAGGACCCTGGTCCGAGGTGTCCCTGAGTATGGCTGCGTGGTGAACTTGCGGA
AGACAGTGGTGAACTTCCCTGTAGAAGACGAGGCCCTGGGTGGCACGGCTTTTGTTCAGATGCCGGCCCACGGCCTATTCCCCTGGTGCG
GCCTGCTGCTGGATACCCGGACCCTGGAGGTGCAGAGCGACTACTCCAGCTATGCCCGGACCTCCATCAGAGCCAGTCTCACCTTCAACC
GCGGCTTCAAGGCTGGGAGGAACATGCGTCGCAAACTCTTTGGGGTCTTGCGGCTGAAGTGTCACAGCCTGTTTCTGGATTTGCAGGTGA
ACAGCCTCCAGACGGTGTGCACCAACATCTACAAGATCCTCCTGCTGCAGGCGTACAGGTTTCACGCATGTGTGCTGCAGCTCCCATTTC
ATCAGCAAGTTTGGAAGAACCCCACATTTTTCCTGCGCGTCATCTCTGACACGGCCTCCCTCTGCTACTCCATCCTGAAAGCCAAGAACG
CAGGGATGTCGCTGGGGGCCAAGGGCGCCGCCGGCCCTCTGCCCTCCGAGGCCGTGCAGTGGCTGTGCCACCAAGCATTCCTGCTCAAGC
TGACTCGACACCGTGTCACCTACGTGCCACTCCTGGGGTCACTCAGGACAGCCCAGACGCAGCTGAGTCGGAAGCTCCCGGGGACGACGC
TGACTGCCCTGGAGGCCGCAGCCAACCCGGCACTGCCCTCAGACTTCAAGACCATCCTGGACTGATGGCCACCCGCCCACAGCCAGGCCG
AGAGCAGACACCAGCAGCCCTGTCACGCCGGGCTCTACGTCCCAGGGAGGGAGGGGCGGCCCACACCCAGGCCCGCACCGCTGGGAGTCT
GAGGCCTGAGTGAGTGTTTGGCCGAGGCCTGCATGTCCGGCTGAAGGCTGAGTGTCCGGCTGAGGCCTGAGCGAGTGTCCAGCCAAGGGC
TGAGTGTCCAGCACACCTGCCGTCTTCACTTCCCCACAGGCTGGCGCTCGGCTCCACCCCAGGGCCAGCTTTTCCTCACCAGGAGCCCGG
CTTCCACTCCCCACATAGGAATAGTCCATCCCCAGATTCGCCATTGTTCACCCCTCGCCCTGCCCTCCTTTGCCTTCCACCCCCACCATC
CAGGTGGAGACCCTGAGAAGGACCCTGGGAGCTCTGGGAATTTGGAGTGACCAAAGGTGTGCCCTGTACACAGGCGAGGACCCTGCACCT

>In-frame_ENST00000442743_ENST00000296820_TCGA-FW-A5DX-01A_DROSHA_chr5_31421379_-_TERT_chr5_1282739_length(amino acids)=1161AA_start in transcript=47_stop in transcript=3532
MMQGNTCHRMSFHPGRGCPRGRGGHGARPSAPSFRPQNLRLLHPQQPPVQYQYEPPSAPSTTFSNSPAPNFLPPRPDFVPFPPPMPPSAQ
GPLPPCPIRPPFPNHQMRHPFPVPPCFPPMPPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHPPPPPVMPQQVNYQYPPGYSHHNFPPP
SFNSFQNNPSSFLPSANNSSSPHFRHLPPYPLPKAPSERRSPERLKHYDDHRHRDHSHGRGERHRSLDRRERGRSPDRRRQDSRYRSDYD
RGRTPSRHRSYERSRERERERHRHRDNRRSPSLERSYKKEYKRSGSRSPSREKKRARWEEEKDRWSDNQSSGKDKNYTSIKEKEPEETMP
DKNEEEEEELLKPVWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKFEEELGSRQEKAKAARPPWEPPKTKLDEDLESSSESECES
DEDSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSAKARRTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRIT
VSPPTNFLTDRPTVIEYDDHEYIFEGFSMFAHAPLTNIPLCKVIRFNIDYTIHFIEEMMPENFCVKGLELFSLFLFRDILELYDWNLKGP
LFEDSPPCCPRFHFMPRFVRFLPDGGKEVLSMHQILLYLLRCSKALVPEEEIANMLQWEELEWQKYAEECKGMIVTNPGTKPSSVRIDQL
DREQFNPDVITFPIIVHFGIRPAQLSYAGDPQYQKLWKSYVKLRHLLANSPKVKQTDKQKLAQREEALQKIRQKNTMRREVTVELSSQGF
WKTGIRSDVCQHAMMLPVLTHHIRYHQCLMHLDKLIGYTFQDRCLLQLAMTHPSHHLNFGMNPDHARNSLSNCGIRQPKYGDRKVHHMHM
RKKGINTLINIMSRLGQDDPTPSRINHNERLEFLGDAVVEFLTSVHLYYLFPSLEEGGLATYRTAIVQNQHLAMLAKKLELDRFMLYAHG
PDLCRESDLRHAMANCFEALIGAVYLEGSLEEAKQLFGRLLFNDPDLREVWLNYPLHPLQLQEPNTDRQLIETSPVLQKLTEFEEAIGVI

--------------------------------------------------------------
>In-frame_ENST00000344624_ENST00000296820_TCGA-FW-A5DX-01A_DROSHA_chr5_31421379_-_TERT_chr5_1282739_length(transcript)=5770nt_BP=3572nt
GAGCTTATATTCTCTGTGGAAGATGTGACATATCCAGGCGGAACATCATGATGCAGGGAAACACATGTCACAGAATGTCGTTCCACCCGG
GACGAGGGTGTCCCCGAGGACGAGGAGGACATGGAGCCAGACCCTCAGCACCATCCTTTAGGCCCCAAAATCTGAGGCTGCTTCACCCTC
AGCAGCCTCCTGTGCAATATCAATATGAACCTCCAAGTGCCCCTTCCACCACTTTCTCAAACTCTCCAGCCCCCAATTTTCTCCCTCCAC
GACCAGACTTTGTACCCTTCCCCCCACCCATGCCTCCGTCAGCGCAAGGCCCTCTTCCCCCCTGCCCAATCAGGCCGCCTTTCCCCAACC
ACCAGATGAGGCACCCCTTCCCAGTTCCTCCTTGTTTTCCTCCCATGCCACCACCAATGCCTTGTCCTAATAACCCCCCAGTCCCTGGGG
CACCTCCTGGACAAGGCACTTTCCCCTTCATGATGCCCCCTCCCTCCATGCCTCATCCCCCGCCCCCTCCAGTCATGCCGCAGCAGGTTA
ATTATCAGTACCCTCCGGGCTATTCTCACCACAACTTCCCACCTCCCAGTTTTAATAGTTTCCAGAACAACCCTAGTTCTTTCCTGCCCA
GTGCTAATAACAGCAGTAGTCCTCATTTCAGACATCTCCCTCCATACCCACTCCCAAAGGCTCCCAGTGAGAGAAGGTCCCCAGAAAGGC
TGAAACACTATGATGACCACAGGCACCGAGATCACAGTCATGGGCGAGGTGAGAGGCATCGGTCCCTGGATCGGCGGGAGCGAGGCCGCA
GTCCCGACAGGAGAAGACAAGACAGCCGGTACAGATCTGATTATGACCGAGGGAGAACACCATCTCGCCACCGCAGCTACGAACGGAGCA
GAGAGCGAGAACGGGAGAGACACAGGCATCGAGACAACCGAAGATCACCATCTCTGGAAAGGTCCTACAAAAAAGAGTATAAGAGATCTG
GAAGGAGTTACGGTTTATCGGTTGTTCCTGAACCTGCTGGATGCACACCAGAATTACCTGGGGAGATTATTAAAAATACAGATTCTTGGG
CCCCACCCCTGGAGATTGTGAATCATCGCTCCCCAAGTAGGGAGAAGAAGAGAGCTCGTTGGGAGGAAGAAAAAGACCGTTGGAGTGACA
ACCAGAGTTCTGGCAAAGACAAGAACTATACCTCAATCAAGGAAAAAGAGCCCGAGGAGACCATGCCTGACAAGAATGAGGAGGAAGAAG
AAGAACTTCTTAAGCCTGTGTGGATTCGATGCACTCATTCAGAAAACTACTACTCCAGTGACCCCATGGATCAGGTGGGAGATTCTACAG
TGGTTGGAACGAGTAGGCTTCGTGACTTATATGACAAATTTGAGGAGGAGTTGGGGAGCAGGCAAGAAAAGGCCAAAGCTGCTCGGCCTC
CGTGGGAACCTCCAAAGACGAAGCTCGATGAAGATTTAGAGAGTTCCAGTGAATCCGAGTGTGAGTCTGATGAGGACAGCACCTGTTCTA
GCAGCTCAGACTCTGAAGTTTTTGACGTTATTGCAGAAATCAAACGCAAAAAGGCCCACCCTGACCGACTTCATGATGAACTTTGGTACA
ACGATCCAGGCCAGATGAATGATGGACCACTCTGCAAATGCAGCGCAAAGGCAAGACGCACAGGAATTAGGCACAGCATTTATCCTGGAG
AAGAGGCCATCAAGCCCTGTCGTCCTATGACCAACAATGCTGGCAGACTTTTCCACTACCGGATCACAGTCTCCCCGCCTACGAACTTTT
TAACTGACAGGCCAACTGTTATAGAATACGATGATCACGAGTATATCTTTGAAGGATTTTCTATGTTTGCACATGCCCCCCTGACCAATA
TTCCACTGTGTAAAGTAATTAGATTCAACATAGACTACACGATTCATTTCATTGAAGAGATGATGCCGGAGAATTTTTGTGTGAAAGGGC
TTGAACTCTTTTCACTGTTCCTATTCAGAGATATTTTGGAATTATATGACTGGAATCTTAAAGGTCCTTTGTTTGAAGACAGCCCTCCCT
GCTGCCCAAGATTTCATTTCATGCCACGTTTTGTAAGATTTCTTCCAGATGGAGGAAAGGAAGTGCTGTCCATGCACCAGATTCTCCTGT
ACTTGTTAAGGTGCAGCAAAGCCCTGGTGCCTGAGGAGGAGATTGCCAATATGCTTCAGTGGGAGGAGCTGGAGTGGCAGAAATATGCAG
AAGAATGCAAAGGCATGATTGTTACCAACCCTGGGACGAAACCAAGCTCTGTCCGTATCGATCAACTGGATCGTGAACAGTTCAACCCCG
ATGTGATTACTTTTCCGATTATCGTCCACTTTGGGATACGCCCTGCACAGTTGAGTTATGCAGGAGACCCACAGTACCAAAAACTGTGGA
AGAGTTATGTGAAACTTCGCCACCTCCTAGCAAATAGTCCCAAAGTCAAACAAACTGACAAACAGAAGCTGGCACAGAGGGAGGAAGCCC
TCCAAAAAATACGGCAGAAGAATACAATGAGACGAGAAGTAACGGTGGAGCTAAGTAGCCAAGGATTCTGGAAAACTGGCATCCGTTCTG
ATGTCTGTCAGCATGCAATGATGCTACCTGTTCTGACCCATCATATCCGCTACCACCAATGCCTAATGCATTTGGACAAGTTGATAGGAT
ATACTTTCCAAGATCGTTGTCTGTTGCAGCTGGCCATGACTCATCCAAGTCATCATTTAAATTTTGGAATGAATCCTGATCATGCCAGGA
ATTCATTATCTAACTGTGGAATTCGGCAGCCCAAATACGGAGACAGAAAAGTTCATCACATGCACATGCGGAAGAAAGGGATTAACACCT
TGATAAATATCATGTCACGCCTTGGCCAAGATGACCCAACTCCCTCGAGGATTAACCACAATGAACGGTTGGAATTCCTGGGTGATGCTG
TTGTTGAATTTCTGACCAGCGTCCATTTGTACTATTTGTTTCCTAGTCTGGAAGAAGGAGGATTAGCAACCTATCGGACTGCCATTGTTC
AGAATCAGCACCTTGCCATGCTAGCAAAGAAACTTGAACTGGATCGATTTATGCTGTATGCTCACGGGCCTGACCTTTGTAGAGAATCGG
ACCTTCGACATGCAATGGCCAATTGTTTTGAAGCGTTAATAGGAGCTGTTTACTTGGAGGGAAGCCTGGAGGAAGCCAAGCAGTTATTTG
GACGCTTGCTCTTTAATGATCCGGACCTGCGCGAAGTCTGGCTCAATTATCCTCTCCACCCACTCCAACTACAAGAGCCAAATACTGATC
GACAACTTATTGAAACTTCTCCAGTTCTACAAAAACTTACTGAGTTTGAAGAAGCAATTGGAGTAATTTTTACTCATGTTCGACTTCTGG
CAAGGGCATTCACATTGAGAACTGTGGGATTTAACCATCTGACCCTAGGCCACAATCAGAGAATGGAATTCCTAGGTGACTCCATAATGC
AACTGGTAGCCACAGAGTACTTATTCATTCATTTCCCAGATCATCATGAAGGACACTTAACTGGGTTGGCTGTGTTCCGGCCGCAGAGCA
CCGTCTGCGTGAGGAGATCCTGGCCAAGTTCCTGCACTGGCTGATGAGTGTGTACGTCGTCGAGCTGCTCAGGTCTTTCTTTTATGTCAC
GGAGACCACGTTTCAAAAGAACAGGCTCTTTTTCTACCGGAAGAGTGTCTGGAGCAAGTTGCAAAGCATTGGAATCAGACAGCACTTGAA
GAGGGTGCAGCTGCGGGAGCTGTCGGAAGCAGAGGTCAGGCAGCATCGGGAAGCCAGGCCCGCCCTGCTGACGTCCAGACTCCGCTTCAT
CCCCAAGCCTGACGGGCTGCGGCCGATTGTGAACATGGACTACGTCGTGGGAGCCAGAACGTTCCGCAGAGAAAAGAGGGCCGAGCGTCT
CACCTCGAGGGTGAAGGCACTGTTCAGCGTGCTCAACTACGAGCGGGCGCGGCGCCCCGGCCTCCTGGGCGCCTCTGTGCTGGGCCTGGA
CGATATCCACAGGGCCTGGCGCACCTTCGTGCTGCGTGTGCGGGCCCAGGACCCGCCGCCTGAGCTGTACTTTGTCAAGGTGGATGTGAC
GGGCGCGTACGACACCATCCCCCAGGACAGGCTCACGGAGGTCATCGCCAGCATCATCAAACCCCAGAACACGTACTGCGTGCGTCGGTA
TGCCGTGGTCCAGAAGGCCGCCCATGGGCACGTCCGCAAGGCCTTCAAGAGCCACGTCCTACGTCCAGTGCCAGGGGATCCCGCAGGGCT
CCATCCTCTCCACGCTGCTCTGCAGCCTGTGCTACGGCGACATGGAGAACAAGCTGTTTGCGGGGATTCGGCGGGACGGGCTGCTCCTGC
GTTTGGTGGATGATTTCTTGTTGGTGACACCTCACCTCACCCACGCGAAAACCTTCCTCAGGACCCTGGTCCGAGGTGTCCCTGAGTATG
GCTGCGTGGTGAACTTGCGGAAGACAGTGGTGAACTTCCCTGTAGAAGACGAGGCCCTGGGTGGCACGGCTTTTGTTCAGATGCCGGCCC
ACGGCCTATTCCCCTGGTGCGGCCTGCTGCTGGATACCCGGACCCTGGAGGTGCAGAGCGACTACTCCAGCTATGCCCGGACCTCCATCA
GAGCCAGTCTCACCTTCAACCGCGGCTTCAAGGCTGGGAGGAACATGCGTCGCAAACTCTTTGGGGTCTTGCGGCTGAAGTGTCACAGCC
TGTTTCTGGATTTGCAGGTGAACAGCCTCCAGACGGTGTGCACCAACATCTACAAGATCCTCCTGCTGCAGGCGTACAGGTTTCACGCAT
GTGTGCTGCAGCTCCCATTTCATCAGCAAGTTTGGAAGAACCCCACATTTTTCCTGCGCGTCATCTCTGACACGGCCTCCCTCTGCTACT
CCATCCTGAAAGCCAAGAACGCAGGGATGTCGCTGGGGGCCAAGGGCGCCGCCGGCCCTCTGCCCTCCGAGGCCGTGCAGTGGCTGTGCC
ACCAAGCATTCCTGCTCAAGCTGACTCGACACCGTGTCACCTACGTGCCACTCCTGGGGTCACTCAGGACAGCCCAGACGCAGCTGAGTC
GGAAGCTCCCGGGGACGACGCTGACTGCCCTGGAGGCCGCAGCCAACCCGGCACTGCCCTCAGACTTCAAGACCATCCTGGACTGATGGC
CACCCGCCCACAGCCAGGCCGAGAGCAGACACCAGCAGCCCTGTCACGCCGGGCTCTACGTCCCAGGGAGGGAGGGGCGGCCCACACCCA
GGCCCGCACCGCTGGGAGTCTGAGGCCTGAGTGAGTGTTTGGCCGAGGCCTGCATGTCCGGCTGAAGGCTGAGTGTCCGGCTGAGGCCTG
AGCGAGTGTCCAGCCAAGGGCTGAGTGTCCAGCACACCTGCCGTCTTCACTTCCCCACAGGCTGGCGCTCGGCTCCACCCCAGGGCCAGC
TTTTCCTCACCAGGAGCCCGGCTTCCACTCCCCACATAGGAATAGTCCATCCCCAGATTCGCCATTGTTCACCCCTCGCCCTGCCCTCCT
TTGCCTTCCACCCCCACCATCCAGGTGGAGACCCTGAGAAGGACCCTGGGAGCTCTGGGAATTTGGAGTGACCAAAGGTGTGCCCTGTAC
ACAGGCGAGGACCCTGCACCTGGATGGGGGTCCCTGTGGGTCAAATTGGGGGGAGGTGCTGTGGGAGTAAAATACTGAATATATGAGTTT

>In-frame_ENST00000344624_ENST00000296820_TCGA-FW-A5DX-01A_DROSHA_chr5_31421379_-_TERT_chr5_1282739_length(amino acids)=1198AA_start in transcript=47_stop in transcript=3643
MMQGNTCHRMSFHPGRGCPRGRGGHGARPSAPSFRPQNLRLLHPQQPPVQYQYEPPSAPSTTFSNSPAPNFLPPRPDFVPFPPPMPPSAQ
GPLPPCPIRPPFPNHQMRHPFPVPPCFPPMPPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHPPPPPVMPQQVNYQYPPGYSHHNFPPP
SFNSFQNNPSSFLPSANNSSSPHFRHLPPYPLPKAPSERRSPERLKHYDDHRHRDHSHGRGERHRSLDRRERGRSPDRRRQDSRYRSDYD
RGRTPSRHRSYERSRERERERHRHRDNRRSPSLERSYKKEYKRSGRSYGLSVVPEPAGCTPELPGEIIKNTDSWAPPLEIVNHRSPSREK
KRARWEEEKDRWSDNQSSGKDKNYTSIKEKEPEETMPDKNEEEEEELLKPVWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKFEE
ELGSRQEKAKAARPPWEPPKTKLDEDLESSSESECESDEDSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSA
KARRTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIEYDDHEYIFEGFSMFAHAPLTNIPLCKVIRFNIDYTIH
FIEEMMPENFCVKGLELFSLFLFRDILELYDWNLKGPLFEDSPPCCPRFHFMPRFVRFLPDGGKEVLSMHQILLYLLRCSKALVPEEEIA
NMLQWEELEWQKYAEECKGMIVTNPGTKPSSVRIDQLDREQFNPDVITFPIIVHFGIRPAQLSYAGDPQYQKLWKSYVKLRHLLANSPKV
KQTDKQKLAQREEALQKIRQKNTMRREVTVELSSQGFWKTGIRSDVCQHAMMLPVLTHHIRYHQCLMHLDKLIGYTFQDRCLLQLAMTHP
SHHLNFGMNPDHARNSLSNCGIRQPKYGDRKVHHMHMRKKGINTLINIMSRLGQDDPTPSRINHNERLEFLGDAVVEFLTSVHLYYLFPS
LEEGGLATYRTAIVQNQHLAMLAKKLELDRFMLYAHGPDLCRESDLRHAMANCFEALIGAVYLEGSLEEAKQLFGRLLFNDPDLREVWLN
YPLHPLQLQEPNTDRQLIETSPVLQKLTEFEEAIGVIFTHVRLLARAFTLRTVGFNHLTLGHNQRMEFLGDSIMQLVATEYLFIHFPDHH

--------------------------------------------------------------
>In-frame_ENST00000513349_ENST00000310581_TCGA-FW-A5DX-01A_DROSHA_chr5_31421379_-_TERT_chr5_1282739_length(transcript)=6170nt_BP=3783nt
GCTTTTTAATTCCCTCGGTTTCCTGTTCCGGAGGCGCGGGCGGTGCCACTGTCTTGGTACCTGCGGTAGTAGCCTGGCTTTGCTCTGACG
GCGATCTCGCGGCCCGAGAGCCTTTTATAGACAGCTCCTTCAGTGTCTCTGTTTCCAAACCGCAACCGAGAAGAGACAGACGGAGAAAAG
AGAGTTACTTTTCCAGGTTGCTTTTCCCGGGGATGTGAAGGATACAGAAATGACTGTGAATCAACCCATATCATCAAGGAGCTGATAATC
TAGTGGAAGAGTTAGACGTGTGCATACTTCACTATGATATGAGGCAGTCTCTGAGCTTATATTCTCTGTGGAAGATGTGACATATCCAGG
CGGAACATCATGATGCAGGGAAACACATGTCACAGAATGTCGTTCCACCCGGGACGAGGGTGTCCCCGAGGACGAGGAGGACATGGAGCC
AGACCCTCAGCACCATCCTTTAGGCCCCAAAATCTGAGGCTGCTTCACCCTCAGCAGCCTCCTGTGCAATATCAATATGAACCTCCAAGT
GCCCCTTCCACCACTTTCTCAAACTCTCCAGCCCCCAATTTTCTCCCTCCACGACCAGACTTTGTACCCTTCCCCCCACCCATGCCTCCG
TCAGCGCAAGGCCCTCTTCCCCCCTGCCCAATCAGGCCGCCTTTCCCCAACCACCAGATGAGGCACCCCTTCCCAGTTCCTCCTTGTTTT
CCTCCCATGCCACCACCAATGCCTTGTCCTAATAACCCCCCAGTCCCTGGGGCACCTCCTGGACAAGGCACTTTCCCCTTCATGATGCCC
CCTCCCTCCATGCCTCATCCCCCGCCCCCTCCAGTCATGCCGCAGCAGGTTAATTATCAGTACCCTCCGGGCTATTCTCACCACAACTTC
CCACCTCCCAGTTTTAATAGTTTCCAGAACAACCCTAGTTCTTTCCTGCCCAGTGCTAATAACAGCAGTAGTCCTCATTTCAGACATCTC
CCTCCATACCCACTCCCAAAGGCTCCCAGTGAGAGAAGGTCCCCAGAAAGGCTGAAACACTATGATGACCACAGGCACCGAGATCACAGT
CATGGGCGAGGTGAGAGGCATCGGTCCCTGGATCGGCGGGAGCGAGGCCGCAGTCCCGACAGGAGAAGACAAGACAGCCGGTACAGATCT
GATTATGACCGAGGGAGAACACCATCTCGCCACCGCAGCTACGAACGGAGCAGAGAGCGAGAACGGGAGAGACACAGGCATCGAGACAAC
CGAAGATCACCATCTCTGGAAAGGTCCTACAAAAAAGAGTATAAGAGATCTGGAAGTCGCTCCCCAAGTAGGGAGAAGAAGAGAGCTCGT
TGGGAGGAAGAAAAAGACCGTTGGAGTGACAACCAGAGTTCTGGCAAAGACAAGAACTATACCTCAATCAAGGAAAAAGAGCCCGAGGAG
ACCATGCCTGACAAGAATGAGGAGGAAGAAGAAGAACTTCTTAAGCCTGTGTGGATTCGATGCACTCATTCAGAAAACTACTACTCCAGT
GACCCCATGGATCAGGTGGGAGATTCTACAGTGGTTGGAACGAGTAGGCTTCGTGACTTATATGACAAATTTGAGGAGGAGTTGGGGAGC
AGGCAAGAAAAGGCCAAAGCTGCTCGGCCTCCGTGGGAACCTCCAAAGACGAAGCTCGATGAAGATTTAGAGAGTTCCAGTGAATCCGAG
TGTGAGTCTGATGAGGACAGCACCTGTTCTAGCAGCTCAGACTCTGAAGTTTTTGACGTTATTGCAGAAATCAAACGCAAAAAGGCCCAC
CCTGACCGACTTCATGATGAACTTTGGTACAACGATCCAGGCCAGATGAATGATGGACCACTCTGCAAATGCAGCGCAAAGGCAAGACGC
ACAGGAATTAGGCACAGCATTTATCCTGGAGAAGAGGCCATCAAGCCCTGTCGTCCTATGACCAACAATGCTGGCAGACTTTTCCACTAC
CGGATCACAGTCTCCCCGCCTACGAACTTTTTAACTGACAGGCCAACTGTTATAGAATACGATGATCACGAGTATATCTTTGAAGGATTT
TCTATGTTTGCACATGCCCCCCTGACCAATATTCCACTGTGTAAAGTAATTAGATTCAACATAGACTACACGATTCATTTCATTGAAGAG
ATGATGCCGGAGAATTTTTGTGTGAAAGGGCTTGAACTCTTTTCACTGTTCCTATTCAGAGATATTTTGGAATTATATGACTGGAATCTT
AAAGGTCCTTTGTTTGAAGACAGCCCTCCCTGCTGCCCAAGATTTCATTTCATGCCACGTTTTGTAAGATTTCTTCCAGATGGAGGAAAG
GAAGTGCTGTCCATGCACCAGATTCTCCTGTACTTGTTAAGGTGCAGCAAAGCCCTGGTGCCTGAGGAGGAGATTGCCAATATGCTTCAG
TGGGAGGAGCTGGAGTGGCAGAAATATGCAGAAGAATGCAAAGGCATGATTGTTACCAACCCTGGGACGAAACCAAGCTCTGTCCGTATC
GATCAACTGGATCGTGAACAGTTCAACCCCGATGTGATTACTTTTCCGATTATCGTCCACTTTGGGATACGCCCTGCACAGTTGAGTTAT
GCAGGAGACCCACAGTACCAAAAACTGTGGAAGAGTTATGTGAAACTTCGCCACCTCCTAGCAAATAGTCCCAAAGTCAAACAAACTGAC
AAACAGAAGCTGGCACAGAGGGAGGAAGCCCTCCAAAAAATACGGCAGAAGAATACAATGAGACGAGAAGTAACGGTGGAGCTAAGTAGC
CAAGGATTCTGGAAAACTGGCATCCGTTCTGATGTCTGTCAGCATGCAATGATGCTACCTGTTCTGACCCATCATATCCGCTACCACCAA
TGCCTAATGCATTTGGACAAGTTGATAGGATATACTTTCCAAGATCGTTGTCTGTTGCAGCTGGCCATGACTCATCCAAGTCATCATTTA
AATTTTGGAATGAATCCTGATCATGCCAGGAATTCATTATCTAACTGTGGAATTCGGCAGCCCAAATACGGAGACAGAAAAGTTCATCAC
ATGCACATGCGGAAGAAAGGGATTAACACCTTGATAAATATCATGTCACGCCTTGGCCAAGATGACCCAACTCCCTCGAGGATTAACCAC
AATGAACGGTTGGAATTCCTGGGTGATGCTGTTGTTGAATTTCTGACCAGCGTCCATTTGTACTATTTGTTTCCTAGTCTGGAAGAAGGA
GGATTAGCAACCTATCGGACTGCCATTGTTCAGAATCAGCACCTTGCCATGCTAGCAAAGAAACTTGAACTGGATCGATTTATGCTGTAT
GCTCACGGGCCTGACCTTTGTAGAGAATCGGACCTTCGACATGCAATGGCCAATTGTTTTGAAGCGTTAATAGGAGCTGTTTACTTGGAG
GGAAGCCTGGAGGAAGCCAAGCAGTTATTTGGACGCTTGCTCTTTAATGATCCGGACCTGCGCGAAGTCTGGCTCAATTATCCTCTCCAC
CCACTCCAACTACAAGAGCCAAATACTGATCGACAACTTATTGAAACTTCTCCAGTTCTACAAAAACTTACTGAGTTTGAAGAAGCAATT
GGAGTAATTTTTACTCATGTTCGACTTCTGGCAAGGGCATTCACATTGAGAACTGTGGGATTTAACCATCTGACCCTAGGCCACAATCAG
AGAATGGAATTCCTAGGTGACTCCATAATGCAACTGGTAGCCACAGAGTACTTATTCATTCATTTCCCAGATCATCATGAAGGACACTTA
ACTGGGTTGGCTGTGTTCCGGCCGCAGAGCACCGTCTGCGTGAGGAGATCCTGGCCAAGTTCCTGCACTGGCTGATGAGTGTGTACGTCG
TCGAGCTGCTCAGGTCTTTCTTTTATGTCACGGAGACCACGTTTCAAAAGAACAGGCTCTTTTTCTACCGGAAGAGTGTCTGGAGCAAGT
TGCAAAGCATTGGAATCAGACAGCACTTGAAGAGGGTGCAGCTGCGGGAGCTGTCGGAAGCAGAGGTCAGGCAGCATCGGGAAGCCAGGC
CCGCCCTGCTGACGTCCAGACTCCGCTTCATCCCCAAGCCTGACGGGCTGCGGCCGATTGTGAACATGGACTACGTCGTGGGAGCCAGAA
CGTTCCGCAGAGAAAAGAGGGCCGAGCGTCTCACCTCGAGGGTGAAGGCACTGTTCAGCGTGCTCAACTACGAGCGGGCGCGGCGCCCCG
GCCTCCTGGGCGCCTCTGTGCTGGGCCTGGACGATATCCACAGGGCCTGGCGCACCTTCGTGCTGCGTGTGCGGGCCCAGGACCCGCCGC
CTGAGCTGTACTTTGTCAAGGTGGATGTGACGGGCGCGTACGACACCATCCCCCAGGACAGGCTCACGGAGGTCATCGCCAGCATCATCA
AACCCCAGAACACGTACTGCGTGCGTCGGTATGCCGTGGTCCAGAAGGCCGCCCATGGGCACGTCCGCAAGGCCTTCAAGAGCCACGTCT
CTACCTTGACAGACCTCCAGCCGTACATGCGACAGTTCGTGGCTCACCTGCAGGAGACCAGCCCGCTGAGGGATGCCGTCGTCATCGAGC
AGAGCTCCTCCCTGAATGAGGCCAGCAGTGGCCTCTTCGACGTCTTCCTACGCTTCATGTGCCACCACGCCGTGCGCATCAGGGGCAAGT
CCTACGTCCAGTGCCAGGGGATCCCGCAGGGCTCCATCCTCTCCACGCTGCTCTGCAGCCTGTGCTACGGCGACATGGAGAACAAGCTGT
TTGCGGGGATTCGGCGGGACGGGCTGCTCCTGCGTTTGGTGGATGATTTCTTGTTGGTGACACCTCACCTCACCCACGCGAAAACCTTCC
TCAGGACCCTGGTCCGAGGTGTCCCTGAGTATGGCTGCGTGGTGAACTTGCGGAAGACAGTGGTGAACTTCCCTGTAGAAGACGAGGCCC
TGGGTGGCACGGCTTTTGTTCAGATGCCGGCCCACGGCCTATTCCCCTGGTGCGGCCTGCTGCTGGATACCCGGACCCTGGAGGTGCAGA
GCGACTACTCCAGCTATGCCCGGACCTCCATCAGAGCCAGTCTCACCTTCAACCGCGGCTTCAAGGCTGGGAGGAACATGCGTCGCAAAC
TCTTTGGGGTCTTGCGGCTGAAGTGTCACAGCCTGTTTCTGGATTTGCAGGTGAACAGCCTCCAGACGGTGTGCACCAACATCTACAAGA
TCCTCCTGCTGCAGGCGTACAGGTTTCACGCATGTGTGCTGCAGCTCCCATTTCATCAGCAAGTTTGGAAGAACCCCACATTTTTCCTGC
GCGTCATCTCTGACACGGCCTCCCTCTGCTACTCCATCCTGAAAGCCAAGAACGCAGGGATGTCGCTGGGGGCCAAGGGCGCCGCCGGCC
CTCTGCCCTCCGAGGCCGTGCAGTGGCTGTGCCACCAAGCATTCCTGCTCAAGCTGACTCGACACCGTGTCACCTACGTGCCACTCCTGG
GGTCACTCAGGACAGCCCAGACGCAGCTGAGTCGGAAGCTCCCGGGGACGACGCTGACTGCCCTGGAGGCCGCAGCCAACCCGGCACTGC
CCTCAGACTTCAAGACCATCCTGGACTGATGGCCACCCGCCCACAGCCAGGCCGAGAGCAGACACCAGCAGCCCTGTCACGCCGGGCTCT
ACGTCCCAGGGAGGGAGGGGCGGCCCACACCCAGGCCCGCACCGCTGGGAGTCTGAGGCCTGAGTGAGTGTTTGGCCGAGGCCTGCATGT
CCGGCTGAAGGCTGAGTGTCCGGCTGAGGCCTGAGCGAGTGTCCAGCCAAGGGCTGAGTGTCCAGCACACCTGCCGTCTTCACTTCCCCA
CAGGCTGGCGCTCGGCTCCACCCCAGGGCCAGCTTTTCCTCACCAGGAGCCCGGCTTCCACTCCCCACATAGGAATAGTCCATCCCCAGA
TTCGCCATTGTTCACCCCTCGCCCTGCCCTCCTTTGCCTTCCACCCCCACCATCCAGGTGGAGACCCTGAGAAGGACCCTGGGAGCTCTG
GGAATTTGGAGTGACCAAAGGTGTGCCCTGTACACAGGCGAGGACCCTGCACCTGGATGGGGGTCCCTGTGGGTCAAATTGGGGGGAGGT

>In-frame_ENST00000513349_ENST00000310581_TCGA-FW-A5DX-01A_DROSHA_chr5_31421379_-_TERT_chr5_1282739_length(amino acids)=1161AA_start in transcript=369_stop in transcript=3854
MMQGNTCHRMSFHPGRGCPRGRGGHGARPSAPSFRPQNLRLLHPQQPPVQYQYEPPSAPSTTFSNSPAPNFLPPRPDFVPFPPPMPPSAQ
GPLPPCPIRPPFPNHQMRHPFPVPPCFPPMPPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHPPPPPVMPQQVNYQYPPGYSHHNFPPP
SFNSFQNNPSSFLPSANNSSSPHFRHLPPYPLPKAPSERRSPERLKHYDDHRHRDHSHGRGERHRSLDRRERGRSPDRRRQDSRYRSDYD
RGRTPSRHRSYERSRERERERHRHRDNRRSPSLERSYKKEYKRSGSRSPSREKKRARWEEEKDRWSDNQSSGKDKNYTSIKEKEPEETMP
DKNEEEEEELLKPVWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKFEEELGSRQEKAKAARPPWEPPKTKLDEDLESSSESECES
DEDSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSAKARRTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRIT
VSPPTNFLTDRPTVIEYDDHEYIFEGFSMFAHAPLTNIPLCKVIRFNIDYTIHFIEEMMPENFCVKGLELFSLFLFRDILELYDWNLKGP
LFEDSPPCCPRFHFMPRFVRFLPDGGKEVLSMHQILLYLLRCSKALVPEEEIANMLQWEELEWQKYAEECKGMIVTNPGTKPSSVRIDQL
DREQFNPDVITFPIIVHFGIRPAQLSYAGDPQYQKLWKSYVKLRHLLANSPKVKQTDKQKLAQREEALQKIRQKNTMRREVTVELSSQGF
WKTGIRSDVCQHAMMLPVLTHHIRYHQCLMHLDKLIGYTFQDRCLLQLAMTHPSHHLNFGMNPDHARNSLSNCGIRQPKYGDRKVHHMHM
RKKGINTLINIMSRLGQDDPTPSRINHNERLEFLGDAVVEFLTSVHLYYLFPSLEEGGLATYRTAIVQNQHLAMLAKKLELDRFMLYAHG
PDLCRESDLRHAMANCFEALIGAVYLEGSLEEAKQLFGRLLFNDPDLREVWLNYPLHPLQLQEPNTDRQLIETSPVLQKLTEFEEAIGVI

--------------------------------------------------------------
>In-frame_ENST00000513349_ENST00000334602_TCGA-FW-A5DX-01A_DROSHA_chr5_31421379_-_TERT_chr5_1282739_length(transcript)=5420nt_BP=3783nt
GCTTTTTAATTCCCTCGGTTTCCTGTTCCGGAGGCGCGGGCGGTGCCACTGTCTTGGTACCTGCGGTAGTAGCCTGGCTTTGCTCTGACG
GCGATCTCGCGGCCCGAGAGCCTTTTATAGACAGCTCCTTCAGTGTCTCTGTTTCCAAACCGCAACCGAGAAGAGACAGACGGAGAAAAG
AGAGTTACTTTTCCAGGTTGCTTTTCCCGGGGATGTGAAGGATACAGAAATGACTGTGAATCAACCCATATCATCAAGGAGCTGATAATC
TAGTGGAAGAGTTAGACGTGTGCATACTTCACTATGATATGAGGCAGTCTCTGAGCTTATATTCTCTGTGGAAGATGTGACATATCCAGG
CGGAACATCATGATGCAGGGAAACACATGTCACAGAATGTCGTTCCACCCGGGACGAGGGTGTCCCCGAGGACGAGGAGGACATGGAGCC
AGACCCTCAGCACCATCCTTTAGGCCCCAAAATCTGAGGCTGCTTCACCCTCAGCAGCCTCCTGTGCAATATCAATATGAACCTCCAAGT
GCCCCTTCCACCACTTTCTCAAACTCTCCAGCCCCCAATTTTCTCCCTCCACGACCAGACTTTGTACCCTTCCCCCCACCCATGCCTCCG
TCAGCGCAAGGCCCTCTTCCCCCCTGCCCAATCAGGCCGCCTTTCCCCAACCACCAGATGAGGCACCCCTTCCCAGTTCCTCCTTGTTTT
CCTCCCATGCCACCACCAATGCCTTGTCCTAATAACCCCCCAGTCCCTGGGGCACCTCCTGGACAAGGCACTTTCCCCTTCATGATGCCC
CCTCCCTCCATGCCTCATCCCCCGCCCCCTCCAGTCATGCCGCAGCAGGTTAATTATCAGTACCCTCCGGGCTATTCTCACCACAACTTC
CCACCTCCCAGTTTTAATAGTTTCCAGAACAACCCTAGTTCTTTCCTGCCCAGTGCTAATAACAGCAGTAGTCCTCATTTCAGACATCTC
CCTCCATACCCACTCCCAAAGGCTCCCAGTGAGAGAAGGTCCCCAGAAAGGCTGAAACACTATGATGACCACAGGCACCGAGATCACAGT
CATGGGCGAGGTGAGAGGCATCGGTCCCTGGATCGGCGGGAGCGAGGCCGCAGTCCCGACAGGAGAAGACAAGACAGCCGGTACAGATCT
GATTATGACCGAGGGAGAACACCATCTCGCCACCGCAGCTACGAACGGAGCAGAGAGCGAGAACGGGAGAGACACAGGCATCGAGACAAC
CGAAGATCACCATCTCTGGAAAGGTCCTACAAAAAAGAGTATAAGAGATCTGGAAGTCGCTCCCCAAGTAGGGAGAAGAAGAGAGCTCGT
TGGGAGGAAGAAAAAGACCGTTGGAGTGACAACCAGAGTTCTGGCAAAGACAAGAACTATACCTCAATCAAGGAAAAAGAGCCCGAGGAG
ACCATGCCTGACAAGAATGAGGAGGAAGAAGAAGAACTTCTTAAGCCTGTGTGGATTCGATGCACTCATTCAGAAAACTACTACTCCAGT
GACCCCATGGATCAGGTGGGAGATTCTACAGTGGTTGGAACGAGTAGGCTTCGTGACTTATATGACAAATTTGAGGAGGAGTTGGGGAGC
AGGCAAGAAAAGGCCAAAGCTGCTCGGCCTCCGTGGGAACCTCCAAAGACGAAGCTCGATGAAGATTTAGAGAGTTCCAGTGAATCCGAG
TGTGAGTCTGATGAGGACAGCACCTGTTCTAGCAGCTCAGACTCTGAAGTTTTTGACGTTATTGCAGAAATCAAACGCAAAAAGGCCCAC
CCTGACCGACTTCATGATGAACTTTGGTACAACGATCCAGGCCAGATGAATGATGGACCACTCTGCAAATGCAGCGCAAAGGCAAGACGC
ACAGGAATTAGGCACAGCATTTATCCTGGAGAAGAGGCCATCAAGCCCTGTCGTCCTATGACCAACAATGCTGGCAGACTTTTCCACTAC
CGGATCACAGTCTCCCCGCCTACGAACTTTTTAACTGACAGGCCAACTGTTATAGAATACGATGATCACGAGTATATCTTTGAAGGATTT
TCTATGTTTGCACATGCCCCCCTGACCAATATTCCACTGTGTAAAGTAATTAGATTCAACATAGACTACACGATTCATTTCATTGAAGAG
ATGATGCCGGAGAATTTTTGTGTGAAAGGGCTTGAACTCTTTTCACTGTTCCTATTCAGAGATATTTTGGAATTATATGACTGGAATCTT
AAAGGTCCTTTGTTTGAAGACAGCCCTCCCTGCTGCCCAAGATTTCATTTCATGCCACGTTTTGTAAGATTTCTTCCAGATGGAGGAAAG
GAAGTGCTGTCCATGCACCAGATTCTCCTGTACTTGTTAAGGTGCAGCAAAGCCCTGGTGCCTGAGGAGGAGATTGCCAATATGCTTCAG
TGGGAGGAGCTGGAGTGGCAGAAATATGCAGAAGAATGCAAAGGCATGATTGTTACCAACCCTGGGACGAAACCAAGCTCTGTCCGTATC
GATCAACTGGATCGTGAACAGTTCAACCCCGATGTGATTACTTTTCCGATTATCGTCCACTTTGGGATACGCCCTGCACAGTTGAGTTAT
GCAGGAGACCCACAGTACCAAAAACTGTGGAAGAGTTATGTGAAACTTCGCCACCTCCTAGCAAATAGTCCCAAAGTCAAACAAACTGAC
AAACAGAAGCTGGCACAGAGGGAGGAAGCCCTCCAAAAAATACGGCAGAAGAATACAATGAGACGAGAAGTAACGGTGGAGCTAAGTAGC
CAAGGATTCTGGAAAACTGGCATCCGTTCTGATGTCTGTCAGCATGCAATGATGCTACCTGTTCTGACCCATCATATCCGCTACCACCAA
TGCCTAATGCATTTGGACAAGTTGATAGGATATACTTTCCAAGATCGTTGTCTGTTGCAGCTGGCCATGACTCATCCAAGTCATCATTTA
AATTTTGGAATGAATCCTGATCATGCCAGGAATTCATTATCTAACTGTGGAATTCGGCAGCCCAAATACGGAGACAGAAAAGTTCATCAC
ATGCACATGCGGAAGAAAGGGATTAACACCTTGATAAATATCATGTCACGCCTTGGCCAAGATGACCCAACTCCCTCGAGGATTAACCAC
AATGAACGGTTGGAATTCCTGGGTGATGCTGTTGTTGAATTTCTGACCAGCGTCCATTTGTACTATTTGTTTCCTAGTCTGGAAGAAGGA
GGATTAGCAACCTATCGGACTGCCATTGTTCAGAATCAGCACCTTGCCATGCTAGCAAAGAAACTTGAACTGGATCGATTTATGCTGTAT
GCTCACGGGCCTGACCTTTGTAGAGAATCGGACCTTCGACATGCAATGGCCAATTGTTTTGAAGCGTTAATAGGAGCTGTTTACTTGGAG
GGAAGCCTGGAGGAAGCCAAGCAGTTATTTGGACGCTTGCTCTTTAATGATCCGGACCTGCGCGAAGTCTGGCTCAATTATCCTCTCCAC
CCACTCCAACTACAAGAGCCAAATACTGATCGACAACTTATTGAAACTTCTCCAGTTCTACAAAAACTTACTGAGTTTGAAGAAGCAATT
GGAGTAATTTTTACTCATGTTCGACTTCTGGCAAGGGCATTCACATTGAGAACTGTGGGATTTAACCATCTGACCCTAGGCCACAATCAG
AGAATGGAATTCCTAGGTGACTCCATAATGCAACTGGTAGCCACAGAGTACTTATTCATTCATTTCCCAGATCATCATGAAGGACACTTA
ACTGGGTTGGCTGTGTTCCGGCCGCAGAGCACCGTCTGCGTGAGGAGATCCTGGCCAAGTTCCTGCACTGGCTGATGAGTGTGTACGTCG
TCGAGCTGCTCAGGTCTTTCTTTTATGTCACGGAGACCACGTTTCAAAAGAACAGGCTCTTTTTCTACCGGAAGAGTGTCTGGAGCAAGT
TGCAAAGCATTGGAATCAGACAGCACTTGAAGAGGGTGCAGCTGCGGGAGCTGTCGGAAGCAGAGGTCAGGCAGCATCGGGAAGCCAGGC
CCGCCCTGCTGACGTCCAGACTCCGCTTCATCCCCAAGCCTGACGGGCTGCGGCCGATTGTGAACATGGACTACGTCGTGGGAGCCAGAA
CGTTCCGCAGAGAAAAGAGGGCCGAGCGTCTCACCTCGAGGGTGAAGGCACTGTTCAGCGTGCTCAACTACGAGCGGGCGCGGCGCCCCG
GCCTCCTGGGCGCCTCTGTGCTGGGCCTGGACGATATCCACAGGGCCTGGCGCACCTTCGTGCTGCGTGTGCGGGCCCAGGACCCGCCGC
CTGAGCTGTACTTTGTCAAGGTGGATGTGACGGGCGCGTACGACACCATCCCCCAGGACAGGCTCACGGAGGTCATCGCCAGCATCATCA
AACCCCAGAACACGTACTGCGTGCGTCGGTATGCCGTGGTCCAGAAGGCCGCCCATGGGCACGTCCGCAAGGCCTTCAAGAGCCACGTCT
CTACCTTGACAGACCTCCAGCCGTACATGCGACAGTTCGTGGCTCACCTGCAGGAGACCAGCCCGCTGAGGGATGCCGTCGTCATCGAGC
AGAGCTCCTCCCTGAATGAGGCCAGCAGTGGCCTCTTCGACGTCTTCCTACGCTTCATGTGCCACCACGCCGTGCGCATCAGGGGCAAGT
CCTACGTCCAGTGCCAGGGGATCCCGCAGGGCTCCATCCTCTCCACGCTGCTCTGCAGCCTGTGCTACGGCGACATGGAGAACAAGCTGT
TTGCGGGGATTCGGCGGGACGGGCTGCTCCTGCGTTTGGTGGATGATTTCTTGTTGGTGACACCTCACCTCACCCACGCGAAAACCTTCC
TCAGCTATGCCCGGACCTCCATCAGAGCCAGTCTCACCTTCAACCGCGGCTTCAAGGCTGGGAGGAACATGCGTCGCAAACTCTTTGGGG
TCTTGCGGCTGAAGTGTCACAGCCTGTTTCTGGATTTGCAGGTGAACAGCCTCCAGACGGTGTGCACCAACATCTACAAGATCCTCCTGC
TGCAGGCGTACAGGTTTCACGCATGTGTGCTGCAGCTCCCATTTCATCAGCAAGTTTGGAAGAACCCCACATTTTTCCTGCGCGTCATCT
CTGACACGGCCTCCCTCTGCTACTCCATCCTGAAAGCCAAGAACGCAGGGATGTCGCTGGGGGCCAAGGGCGCCGCCGGCCCTCTGCCCT
CCGAGGCCGTGCAGTGGCTGTGCCACCAAGCATTCCTGCTCAAGCTGACTCGACACCGTGTCACCTACGTGCCACTCCTGGGGTCACTCA
GGACAGCCCAGACGCAGCTGAGTCGGAAGCTCCCGGGGACGACGCTGACTGCCCTGGAGGCCGCAGCCAACCCGGCACTGCCCTCAGACT

>In-frame_ENST00000513349_ENST00000334602_TCGA-FW-A5DX-01A_DROSHA_chr5_31421379_-_TERT_chr5_1282739_length(amino acids)=1161AA_start in transcript=369_stop in transcript=3854
MMQGNTCHRMSFHPGRGCPRGRGGHGARPSAPSFRPQNLRLLHPQQPPVQYQYEPPSAPSTTFSNSPAPNFLPPRPDFVPFPPPMPPSAQ
GPLPPCPIRPPFPNHQMRHPFPVPPCFPPMPPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHPPPPPVMPQQVNYQYPPGYSHHNFPPP
SFNSFQNNPSSFLPSANNSSSPHFRHLPPYPLPKAPSERRSPERLKHYDDHRHRDHSHGRGERHRSLDRRERGRSPDRRRQDSRYRSDYD
RGRTPSRHRSYERSRERERERHRHRDNRRSPSLERSYKKEYKRSGSRSPSREKKRARWEEEKDRWSDNQSSGKDKNYTSIKEKEPEETMP
DKNEEEEEELLKPVWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKFEEELGSRQEKAKAARPPWEPPKTKLDEDLESSSESECES
DEDSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSAKARRTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRIT
VSPPTNFLTDRPTVIEYDDHEYIFEGFSMFAHAPLTNIPLCKVIRFNIDYTIHFIEEMMPENFCVKGLELFSLFLFRDILELYDWNLKGP
LFEDSPPCCPRFHFMPRFVRFLPDGGKEVLSMHQILLYLLRCSKALVPEEEIANMLQWEELEWQKYAEECKGMIVTNPGTKPSSVRIDQL
DREQFNPDVITFPIIVHFGIRPAQLSYAGDPQYQKLWKSYVKLRHLLANSPKVKQTDKQKLAQREEALQKIRQKNTMRREVTVELSSQGF
WKTGIRSDVCQHAMMLPVLTHHIRYHQCLMHLDKLIGYTFQDRCLLQLAMTHPSHHLNFGMNPDHARNSLSNCGIRQPKYGDRKVHHMHM
RKKGINTLINIMSRLGQDDPTPSRINHNERLEFLGDAVVEFLTSVHLYYLFPSLEEGGLATYRTAIVQNQHLAMLAKKLELDRFMLYAHG
PDLCRESDLRHAMANCFEALIGAVYLEGSLEEAKQLFGRLLFNDPDLREVWLNYPLHPLQLQEPNTDRQLIETSPVLQKLTEFEEAIGVI

--------------------------------------------------------------
>In-frame_ENST00000513349_ENST00000508104_TCGA-FW-A5DX-01A_DROSHA_chr5_31421379_-_TERT_chr5_1282739_length(transcript)=4696nt_BP=3783nt
GCTTTTTAATTCCCTCGGTTTCCTGTTCCGGAGGCGCGGGCGGTGCCACTGTCTTGGTACCTGCGGTAGTAGCCTGGCTTTGCTCTGACG
GCGATCTCGCGGCCCGAGAGCCTTTTATAGACAGCTCCTTCAGTGTCTCTGTTTCCAAACCGCAACCGAGAAGAGACAGACGGAGAAAAG
AGAGTTACTTTTCCAGGTTGCTTTTCCCGGGGATGTGAAGGATACAGAAATGACTGTGAATCAACCCATATCATCAAGGAGCTGATAATC
TAGTGGAAGAGTTAGACGTGTGCATACTTCACTATGATATGAGGCAGTCTCTGAGCTTATATTCTCTGTGGAAGATGTGACATATCCAGG
CGGAACATCATGATGCAGGGAAACACATGTCACAGAATGTCGTTCCACCCGGGACGAGGGTGTCCCCGAGGACGAGGAGGACATGGAGCC
AGACCCTCAGCACCATCCTTTAGGCCCCAAAATCTGAGGCTGCTTCACCCTCAGCAGCCTCCTGTGCAATATCAATATGAACCTCCAAGT
GCCCCTTCCACCACTTTCTCAAACTCTCCAGCCCCCAATTTTCTCCCTCCACGACCAGACTTTGTACCCTTCCCCCCACCCATGCCTCCG
TCAGCGCAAGGCCCTCTTCCCCCCTGCCCAATCAGGCCGCCTTTCCCCAACCACCAGATGAGGCACCCCTTCCCAGTTCCTCCTTGTTTT
CCTCCCATGCCACCACCAATGCCTTGTCCTAATAACCCCCCAGTCCCTGGGGCACCTCCTGGACAAGGCACTTTCCCCTTCATGATGCCC
CCTCCCTCCATGCCTCATCCCCCGCCCCCTCCAGTCATGCCGCAGCAGGTTAATTATCAGTACCCTCCGGGCTATTCTCACCACAACTTC
CCACCTCCCAGTTTTAATAGTTTCCAGAACAACCCTAGTTCTTTCCTGCCCAGTGCTAATAACAGCAGTAGTCCTCATTTCAGACATCTC
CCTCCATACCCACTCCCAAAGGCTCCCAGTGAGAGAAGGTCCCCAGAAAGGCTGAAACACTATGATGACCACAGGCACCGAGATCACAGT
CATGGGCGAGGTGAGAGGCATCGGTCCCTGGATCGGCGGGAGCGAGGCCGCAGTCCCGACAGGAGAAGACAAGACAGCCGGTACAGATCT
GATTATGACCGAGGGAGAACACCATCTCGCCACCGCAGCTACGAACGGAGCAGAGAGCGAGAACGGGAGAGACACAGGCATCGAGACAAC
CGAAGATCACCATCTCTGGAAAGGTCCTACAAAAAAGAGTATAAGAGATCTGGAAGTCGCTCCCCAAGTAGGGAGAAGAAGAGAGCTCGT
TGGGAGGAAGAAAAAGACCGTTGGAGTGACAACCAGAGTTCTGGCAAAGACAAGAACTATACCTCAATCAAGGAAAAAGAGCCCGAGGAG
ACCATGCCTGACAAGAATGAGGAGGAAGAAGAAGAACTTCTTAAGCCTGTGTGGATTCGATGCACTCATTCAGAAAACTACTACTCCAGT
GACCCCATGGATCAGGTGGGAGATTCTACAGTGGTTGGAACGAGTAGGCTTCGTGACTTATATGACAAATTTGAGGAGGAGTTGGGGAGC
AGGCAAGAAAAGGCCAAAGCTGCTCGGCCTCCGTGGGAACCTCCAAAGACGAAGCTCGATGAAGATTTAGAGAGTTCCAGTGAATCCGAG
TGTGAGTCTGATGAGGACAGCACCTGTTCTAGCAGCTCAGACTCTGAAGTTTTTGACGTTATTGCAGAAATCAAACGCAAAAAGGCCCAC
CCTGACCGACTTCATGATGAACTTTGGTACAACGATCCAGGCCAGATGAATGATGGACCACTCTGCAAATGCAGCGCAAAGGCAAGACGC
ACAGGAATTAGGCACAGCATTTATCCTGGAGAAGAGGCCATCAAGCCCTGTCGTCCTATGACCAACAATGCTGGCAGACTTTTCCACTAC
CGGATCACAGTCTCCCCGCCTACGAACTTTTTAACTGACAGGCCAACTGTTATAGAATACGATGATCACGAGTATATCTTTGAAGGATTT
TCTATGTTTGCACATGCCCCCCTGACCAATATTCCACTGTGTAAAGTAATTAGATTCAACATAGACTACACGATTCATTTCATTGAAGAG
ATGATGCCGGAGAATTTTTGTGTGAAAGGGCTTGAACTCTTTTCACTGTTCCTATTCAGAGATATTTTGGAATTATATGACTGGAATCTT
AAAGGTCCTTTGTTTGAAGACAGCCCTCCCTGCTGCCCAAGATTTCATTTCATGCCACGTTTTGTAAGATTTCTTCCAGATGGAGGAAAG
GAAGTGCTGTCCATGCACCAGATTCTCCTGTACTTGTTAAGGTGCAGCAAAGCCCTGGTGCCTGAGGAGGAGATTGCCAATATGCTTCAG
TGGGAGGAGCTGGAGTGGCAGAAATATGCAGAAGAATGCAAAGGCATGATTGTTACCAACCCTGGGACGAAACCAAGCTCTGTCCGTATC
GATCAACTGGATCGTGAACAGTTCAACCCCGATGTGATTACTTTTCCGATTATCGTCCACTTTGGGATACGCCCTGCACAGTTGAGTTAT
GCAGGAGACCCACAGTACCAAAAACTGTGGAAGAGTTATGTGAAACTTCGCCACCTCCTAGCAAATAGTCCCAAAGTCAAACAAACTGAC
AAACAGAAGCTGGCACAGAGGGAGGAAGCCCTCCAAAAAATACGGCAGAAGAATACAATGAGACGAGAAGTAACGGTGGAGCTAAGTAGC
CAAGGATTCTGGAAAACTGGCATCCGTTCTGATGTCTGTCAGCATGCAATGATGCTACCTGTTCTGACCCATCATATCCGCTACCACCAA
TGCCTAATGCATTTGGACAAGTTGATAGGATATACTTTCCAAGATCGTTGTCTGTTGCAGCTGGCCATGACTCATCCAAGTCATCATTTA
AATTTTGGAATGAATCCTGATCATGCCAGGAATTCATTATCTAACTGTGGAATTCGGCAGCCCAAATACGGAGACAGAAAAGTTCATCAC
ATGCACATGCGGAAGAAAGGGATTAACACCTTGATAAATATCATGTCACGCCTTGGCCAAGATGACCCAACTCCCTCGAGGATTAACCAC
AATGAACGGTTGGAATTCCTGGGTGATGCTGTTGTTGAATTTCTGACCAGCGTCCATTTGTACTATTTGTTTCCTAGTCTGGAAGAAGGA
GGATTAGCAACCTATCGGACTGCCATTGTTCAGAATCAGCACCTTGCCATGCTAGCAAAGAAACTTGAACTGGATCGATTTATGCTGTAT
GCTCACGGGCCTGACCTTTGTAGAGAATCGGACCTTCGACATGCAATGGCCAATTGTTTTGAAGCGTTAATAGGAGCTGTTTACTTGGAG
GGAAGCCTGGAGGAAGCCAAGCAGTTATTTGGACGCTTGCTCTTTAATGATCCGGACCTGCGCGAAGTCTGGCTCAATTATCCTCTCCAC
CCACTCCAACTACAAGAGCCAAATACTGATCGACAACTTATTGAAACTTCTCCAGTTCTACAAAAACTTACTGAGTTTGAAGAAGCAATT
GGAGTAATTTTTACTCATGTTCGACTTCTGGCAAGGGCATTCACATTGAGAACTGTGGGATTTAACCATCTGACCCTAGGCCACAATCAG
AGAATGGAATTCCTAGGTGACTCCATAATGCAACTGGTAGCCACAGAGTACTTATTCATTCATTTCCCAGATCATCATGAAGGACACTTA
ACTGGGTTGGCTGTGTTCCGGCCGCAGAGCACCGTCTGCGTGAGGAGATCCTGGCCAAGTTCCTGCACTGGCTGATGAGTGTGTACGTCG
TCGAGCTGCTCAGGTCTTTCTTTTATGTCACGGAGACCACGTTTCAAAAGAACAGGCTCTTTTTCTACCGGAAGAGTGTCTGGAGCAAGT
TGCAAAGCATTGGAATCAGACAGCACTTGAAGAGGGTGCAGCTGCGGGAGCTGTCGGAAGCAGAGGTCAGGCAGCATCGGGAAGCCAGGC
CCGCCCTGCTGACGTCCAGACTCCGCTTCATCCCCAAGCCTGACGGGCTGCGGCCGATTGTGAACATGGACTACGTCGTGGGAGCCAGAA
CGTTCCGCAGAGAAAAGAGGGCCGAGCGTCTCACCTCGAGGGTGAAGGCACTGTTCAGCGTGCTCAACTACGAGCGGGCGCGGCGCCCCG
GCCTCCTGGGCGCCTCTGTGCTGGGCCTGGACGATATCCACAGGGCCTGGCGCACCTTCGTGCTGCGTGTGCGGGCCCAGGACCCGCCGC
CTGAGCTGTACTTTGTCAAGGTGGATGTGACGGGCGCGTACGACACCATCCCCCAGGACAGGCTCACGGAGGTCATCGCCAGCATCATCA
AACCCCAGAACACGTACTGCGTGCGTCGGTATGCCGTGGTCCAGAAGGCCGCCCATGGGCACGTCCGCAAGGCCTTCAAGAGCCACGTCC
TACGTCCAGTGCCAGGGGATCCCGCAGGGCTCCATCCTCTCCACGCTGCTCTGCAGCCTGTGCTACGGCGACATGGAGAACAAGCTGTTT
GCGGGGATTCGGCGGGACGGGCTGCTCCTGCGTTTGGTGGATGATTTCTTGTTGGTGACACCTCACCTCACCCACGCGAAAACCTTCCTC

>In-frame_ENST00000513349_ENST00000508104_TCGA-FW-A5DX-01A_DROSHA_chr5_31421379_-_TERT_chr5_1282739_length(amino acids)=1161AA_start in transcript=369_stop in transcript=3854
MMQGNTCHRMSFHPGRGCPRGRGGHGARPSAPSFRPQNLRLLHPQQPPVQYQYEPPSAPSTTFSNSPAPNFLPPRPDFVPFPPPMPPSAQ
GPLPPCPIRPPFPNHQMRHPFPVPPCFPPMPPPMPCPNNPPVPGAPPGQGTFPFMMPPPSMPHPPPPPVMPQQVNYQYPPGYSHHNFPPP
SFNSFQNNPSSFLPSANNSSSPHFRHLPPYPLPKAPSERRSPERLKHYDDHRHRDHSHGRGERHRSLDRRERGRSPDRRRQDSRYRSDYD
RGRTPSRHRSYERSRERERERHRHRDNRRSPSLERSYKKEYKRSGSRSPSREKKRARWEEEKDRWSDNQSSGKDKNYTSIKEKEPEETMP
DKNEEEEEELLKPVWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKFEEELGSRQEKAKAARPPWEPPKTKLDEDLESSSESECES
DEDSTCSSSSDSEVFDVIAEIKRKKAHPDRLHDELWYNDPGQMNDGPLCKCSAKARRTGIRHSIYPGEEAIKPCRPMTNNAGRLFHYRIT
VSPPTNFLTDRPTVIEYDDHEYIFEGFSMFAHAPLTNIPLCKVIRFNIDYTIHFIEEMMPENFCVKGLELFSLFLFRDILELYDWNLKGP
LFEDSPPCCPRFHFMPRFVRFLPDGGKEVLSMHQILLYLLRCSKALVPEEEIANMLQWEELEWQKYAEECKGMIVTNPGTKPSSVRIDQL
DREQFNPDVITFPIIVHFGIRPAQLSYAGDPQYQKLWKSYVKLRHLLANSPKVKQTDKQKLAQREEALQKIRQKNTMRREVTVELSSQGF
WKTGIRSDVCQHAMMLPVLTHHIRYHQCLMHLDKLIGYTFQDRCLLQLAMTHPSHHLNFGMNPDHARNSLSNCGIRQPKYGDRKVHHMHM
RKKGINTLINIMSRLGQDDPTPSRINHNERLEFLGDAVVEFLTSVHLYYLFPSLEEGGLATYRTAIVQNQHLAMLAKKLELDRFMLYAHG
PDLCRESDLRHAMANCFEALIGAVYLEGSLEEAKQLFGRLLFNDPDLREVWLNYPLHPLQLQEPNTDRQLIETSPVLQKLTEFEEAIGVI

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for DROSHA-TERT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for DROSHA-TERT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DROSHA-TERT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDROSHAC0021364Male infertility1CTD_human
HgeneDROSHAC0027708Nephroblastoma1CTD_human
HgeneDROSHAC0848676Subfertility, Male1CTD_human
HgeneDROSHAC0917731Male sterility1CTD_human
HgeneDROSHAC2930471Bilateral Wilms Tumor1CTD_human
TgeneTERTC3151443DYSKERATOSIS CONGENITA, AUTOSOMAL DOMINANT 211CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneTERTC3553617PULMONARY FIBROSIS AND/OR BONE MARROW FAILURE, TELOMERE-RELATED, 18CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneTERTC0002874Aplastic Anemia6CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneTERTC0265965Dyskeratosis Congenita5CTD_human;GENOMICS_ENGLAND
TgeneTERTC1800706Idiopathic Pulmonary Fibrosis5CTD_human;ORPHANET
TgeneTERTC4721508Hamman-Rich Disease5CTD_human
TgeneTERTC4721509Usual Interstitial Pneumonia5CTD_human
TgeneTERTC4721952Familial Idiopathic Pulmonary Fibrosis5CTD_human
TgeneTERTC2239176Liver carcinoma4CTD_human
TgeneTERTC0023467Leukemia, Myelocytic, Acute3CTD_human;GENOMICS_ENGLAND
TgeneTERTC1148551X-Linked Dyskeratosis Congenita3CTD_human
TgeneTERTC1956346Coronary Artery Disease3CTD_human;GENOMICS_ENGLAND
TgeneTERTC0017638Glioma2CTD_human
TgeneTERTC0024121Lung Neoplasms2CTD_human
TgeneTERTC0025202melanoma2CTD_human;GENOMICS_ENGLAND
TgeneTERTC0030297Pancreatic Neoplasm2CTD_human
TgeneTERTC0033578Prostatic Neoplasms2CTD_human
TgeneTERTC0242379Malignant neoplasm of lung2CTD_human
TgeneTERTC0259783mixed gliomas2CTD_human
TgeneTERTC0334488Clear cell sarcoma of kidney2ORPHANET
TgeneTERTC0346647Malignant neoplasm of pancreas2CTD_human
TgeneTERTC0348890Aplastic anemia, idiopathic2ORPHANET
TgeneTERTC0376358Malignant neoplasm of prostate2CTD_human
TgeneTERTC0555198Malignant Glioma2CTD_human
TgeneTERTC1846142HOYERAAL-HREIDARSSON SYNDROME2CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneTERTC3554574MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 92CTD_human;GENOMICS_ENGLAND
TgeneTERTC0005684Malignant neoplasm of urinary bladder1CTD_human
TgeneTERTC0005695Bladder Neoplasm1CTD_human
TgeneTERTC0006142Malignant neoplasm of breast1CTD_human
TgeneTERTC0006826Malignant Neoplasms1CTD_human
TgeneTERTC0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneTERTC0007873Uterine Cervical Neoplasm1CTD_human
TgeneTERTC0010054Coronary Arteriosclerosis1CTD_human
TgeneTERTC0010314Cri-du-Chat Syndrome1CTD_human
TgeneTERTC0022658Kidney Diseases1CTD_human
TgeneTERTC0023448Lymphoid leukemia1CTD_human
TgeneTERTC0023473Myeloid Leukemia, Chronic1CTD_human
TgeneTERTC0023903Liver neoplasms1CTD_human
TgeneTERTC0024115Lung diseases1GENOMICS_ENGLAND
TgeneTERTC0024141Lupus Erythematosus, Systemic1CTD_human
TgeneTERTC0027022Myeloproliferative disease1CTD_human
TgeneTERTC0027651Neoplasms1CTD_human
TgeneTERTC0027819Neuroblastoma1CTD_human
TgeneTERTC0035126Reperfusion Injury1CTD_human
TgeneTERTC0040136Thyroid Neoplasm1CTD_human
TgeneTERTC0041696Unipolar Depression1PSYGENET
TgeneTERTC0085786Hamman-Rich syndrome1ORPHANET
TgeneTERTC0086692Benign Neoplasm1CTD_human
TgeneTERTC0151468Thyroid Gland Follicular Adenoma1CTD_human
TgeneTERTC0178416Hypoplastic anemia1CTD_human
TgeneTERTC0206686Adrenocortical carcinoma1CTD_human
TgeneTERTC0235874Disease Exacerbation1CTD_human
TgeneTERTC0242380Libman-Sacks Disease1CTD_human
TgeneTERTC0345904Malignant neoplasm of liver1CTD_human
TgeneTERTC0549473Thyroid carcinoma1CTD_human
TgeneTERTC0678222Breast Carcinoma1CTD_human
TgeneTERTC0919267ovarian neoplasm1CTD_human
TgeneTERTC1140680Malignant neoplasm of ovary1CTD_human
TgeneTERTC1257931Mammary Neoplasms, Human1CTD_human
TgeneTERTC1269683Major Depressive Disorder1PSYGENET
TgeneTERTC1368275Pigmented Basal Cell Carcinoma1CTD_human
TgeneTERTC1458155Mammary Neoplasms1CTD_human
TgeneTERTC2314896Familial Atypical Mole Melanoma Syndrome1ORPHANET
TgeneTERTC3151444DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE, 41GENOMICS_ENGLAND
TgeneTERTC4048328cervical cancer1CTD_human
TgeneTERTC4704874Mammary Carcinoma, Human1CTD_human
TgeneTERTC4721806Carcinoma, Basal Cell1CTD_human