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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DTX4-KRT7 (FusionGDB2 ID:24403)

Fusion Gene Summary for DTX4-KRT7

check button Fusion gene summary
Fusion gene informationFusion gene name: DTX4-KRT7
Fusion gene ID: 24403
HgeneTgene
Gene symbol

DTX4

KRT7

Gene ID

23220

3855

Gene namedeltex E3 ubiquitin ligase 4keratin 7
SynonymsRNF155CK7|K2C7|K7|SCL
Cytomap

11q12.1

12q13.13

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase DTX4RING finger protein 155RING-type E3 ubiquitin transferase DTX4deltex 4 homologdeltex 4, E3 ubiquitin ligasedeltex homolog 4deltex4protein deltex-4keratin, type II cytoskeletal 7CK-7cytokeratin 7keratin 7, type IIkeratin, 55K type II cytoskeletalkeratin, simple epithelial type I, K7sarcolectintype II mesothelial keratin K7type-II keratin Kb7
Modification date2020031320200313
UniProtAcc

Q9Y2E6

Q5XKE5

Ensembl transtripts involved in fusion geneENST00000532982, ENST00000227451, 
ENST00000531902, 		ENST00000331817, 
ENST00000552322, 
Fusion gene scores* DoF score7 X 5 X 5=1759 X 10 X 4=360
# samples 89
** MAII scorelog2(8/175*10)=-1.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/360*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DTX4 [Title/Abstract] AND KRT7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDTX4(58949935)-KRT7(52631292), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DTX4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across KRT7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-23-2081DTX4chr11

58949935

+KRT7chr12

52631292

+


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Fusion Gene ORF analysis for DTX4-KRT7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000532982ENST00000331817DTX4chr11

58949935

+KRT7chr12

52631292

+
5CDS-intronENST00000532982ENST00000552322DTX4chr11

58949935

+KRT7chr12

52631292

+
In-frameENST00000227451ENST00000331817DTX4chr11

58949935

+KRT7chr12

52631292

+
5CDS-intronENST00000227451ENST00000552322DTX4chr11

58949935

+KRT7chr12

52631292

+
intron-3CDSENST00000531902ENST00000331817DTX4chr11

58949935

+KRT7chr12

52631292

+
intron-intronENST00000531902ENST00000552322DTX4chr11

58949935

+KRT7chr12

52631292

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000532982DTX4chr1158949935+ENST00000331817KRT7chr1252631292+18187831661656496
ENST00000227451DTX4chr1158949935+ENST00000331817KRT7chr1252631292+207410391041912602

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000532982ENST00000331817DTX4chr1158949935+KRT7chr1252631292+0.0141388940.98586106
ENST00000227451ENST00000331817DTX4chr1158949935+KRT7chr1252631292+0.027739420.9722606

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Fusion Genomic Features for DTX4-KRT7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DTX4chr1158949935+KRT7chr1252631292+0.0021766910.99782336
DTX4chr1158949935+KRT7chr1252631292+0.0021766910.99782336

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DTX4-KRT7


check button Go to

FGviewer for the breakpoints of chr11:58949935-chr12:52631292

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DTX4

Q9Y2E6

KRT7

Q5XKE5

FUNCTION: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4. {ECO:0000250, ECO:0000269|PubMed:22388039}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDTX4chr11:58949935chr12:52631292ENST00000227451+291_78311.6666666666667620.0DomainWWE 1
HgeneDTX4chr11:58949935chr12:52631292ENST00000227451+2979_155311.6666666666667620.0DomainWWE 2
HgeneDTX4chr11:58949935chr12:52631292ENST00000532982+291_78205.66666666666666514.0DomainWWE 1
HgeneDTX4chr11:58949935chr12:52631292ENST00000532982+2979_155205.66666666666666514.0DomainWWE 2
TgeneKRT7chr11:58949935chr12:52631292ENST0000033181719237_260178.66666666666666470.0RegionNote=Linker 12
TgeneKRT7chr11:58949935chr12:52631292ENST0000033181719261_399178.66666666666666470.0RegionNote=Coil 2
TgeneKRT7chr11:58949935chr12:52631292ENST0000033181719400_469178.66666666666666470.0RegionNote=Tail

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDTX4chr11:58949935chr12:52631292ENST00000227451+29409_468311.6666666666667620.0Zinc fingerRING-type%3B atypical
HgeneDTX4chr11:58949935chr12:52631292ENST00000532982+29409_468205.66666666666666514.0Zinc fingerRING-type%3B atypical
TgeneKRT7chr11:58949935chr12:52631292ENST000003318171991_403178.66666666666666470.0DomainIF rod
TgeneKRT7chr11:58949935chr12:52631292ENST0000033181719127_144178.66666666666666470.0RegionNote=Linker 1
TgeneKRT7chr11:58949935chr12:52631292ENST0000033181719145_236178.66666666666666470.0RegionNote=Coil 1B
TgeneKRT7chr11:58949935chr12:52631292ENST00000331817192_90178.66666666666666470.0RegionNote=Head
TgeneKRT7chr11:58949935chr12:52631292ENST000003318171990_126178.66666666666666470.0RegionNote=Coil 1A


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Fusion Gene Sequence for DTX4-KRT7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000532982_ENST00000331817_TCGA-23-2081_DTX4_chr11_58949935_+_KRT7_chr12_52631292_length(transcript)=1818nt_BP=783nt
TGCGTCTTCCTGACTCTAGTACGTTGAATCTGGCCAGAAAAACCACATTTGCTCTCTACGAACTCTCCGCCCAGTTCGCCGCAACTACTA
CGACCCCTCCTCGGCCCCTGGGAAGGGCGTGGTGTGGGAGTGGGAGAACGACAATGGCTCCTGGACGCCCTACGACATGGAAGTGGGCAT
CACCATCCAGCATGCCTATGAGAAGCAGCACCCCTGGATCGACCTCACTTCCATTGGCTTTAGCTACGTAATTGACTTCAACACCATGGG
CCAGATCAACCGTCAGACCCAGCGCCAACGCCGCGTCCGCCGGCGCCTCGACCTCATCTACCCCATGGTCACAGGGACCTTGCCTAAGGC
TCAGTCCTGGCCAGTCAGCCCTGGGCCAGCCACCTCGCCCCCCATGTCCCCCTGCTCCTGTCCCCAGTGTGTCTTGGTGATGAGTGTTAA
GGCAGCCGTGGTCAATGGCAGCACTGGGCCCCTACAGCTGCCAGTGACCCGCAAGAACATGCCGCCTCCTGGAGTGGTCAAGCTACCCCC
ACTGCCAGGCTCTGGGGCCAAGCCACTGGACAGCACAGGCACCATTCGAGGCCCACTGAAGACCGCCCCATCGCAGGTGATCCGGAGACA
AGCCTCCAGCATGCCCACTGGGACAACCATGGGCTCTCCTGCCAGTCCCCCAGGACCCAACAGCAAGACCGGAAGGGTGGCCCTGGCCAC
CTTGAATCGTACCAACCTGCAGCGACTGGCCATTGCCCAGTCCCGGGTGCTGATCGCCTCTGGGTACGAAGATGAAATTAACCACCGCAC
AGCTGCTGAGAATGAGTTTGTGGTGCTGAAGAAGGATGTGGATGCTGCCTACATGAGCAAGGTGGAGCTGGAGGCCAAGGTGGATGCCCT
GAATGATGAGATCAACTTCCTCAGGACCCTCAATGAGACGGAGTTGACAGAGCTGCAGTCCCAGATCTCCGACACATCTGTGGTGCTGTC
CATGGACAACAGTCGCTCCCTGGACCTGGACGGCATCATCGCTGAGGTCAAGGCGCAGTATGAGGAGATGGCCAAATGCAGCCGGGCTGA
GGCTGAAGCCTGGTACCAGACCAAGTTTGAGACCCTCCAGGCCCAGGCTGGGAAGCATGGGGACGACCTCCGGAATACCCGGAATGAGAT
TTCAGAGATGAACCGGGCCATCCAGAGGCTGCAGGCTGAGATCGACAACATCAAGAACCAGCGTGCCAAGTTGGAGGCCGCCATTGCCGA
GGCTGAGGAGCGTGGGGAGCTGGCGCTCAAGGATGCTCGTGCCAAGCAGGAGGAGCTGGAAGCCGCCCTGCAGCGGGGCAAGCAGGATAT
GGCACGGCAGCTGCGTGAGTACCAGGAACTCATGAGCGTGAAGCTGGCCCTGGACATCGAGATCGCCACCTACCGCAAGCTGCTGGAGGG
CGAGGAGAGCCGGTTGGCTGGAGATGGAGTGGGAGCCGTGAATATCTCTGTGATGAATTCCACTGGTGGCAGTAGCAGTGGCGGTGGCAT
TGGGCTGACCCTCGGGGGAACCATGGGCAGCAATGCCCTGAGCTTCTCCAGCAGTGCGGGTCCTGGGCTCCTGAAGGCTTATTCCATCCG
GACCGCATCCGCCAGTCGCAGGAGTGCCCGCGACTGAGCCGCCTCCCACCACTCCACTCCTCCAGCCACCACCCACAATCACAAGAAGAT
TCCCACCCCTGCCTCCCATGCCTGGTCCCAAGACAGTGAGACAGTCTGGAAAGTGATGTCAGAATAGCTTCCAATAAAGCAGCCTCATTC

>In-frame_ENST00000532982_ENST00000331817_TCGA-23-2081_DTX4_chr11_58949935_+_KRT7_chr12_52631292_length(amino acids)=496AA_start in transcript=166_stop in transcript=1656
MEVGITIQHAYEKQHPWIDLTSIGFSYVIDFNTMGQINRQTQRQRRVRRRLDLIYPMVTGTLPKAQSWPVSPGPATSPPMSPCSCPQCVL
VMSVKAAVVNGSTGPLQLPVTRKNMPPPGVVKLPPLPGSGAKPLDSTGTIRGPLKTAPSQVIRRQASSMPTGTTMGSPASPPGPNSKTGR
VALATLNRTNLQRLAIAQSRVLIASGYEDEINHRTAAENEFVVLKKDVDAAYMSKVELEAKVDALNDEINFLRTLNETELTELQSQISDT
SVVLSMDNSRSLDLDGIIAEVKAQYEEMAKCSRAEAEAWYQTKFETLQAQAGKHGDDLRNTRNEISEMNRAIQRLQAEIDNIKNQRAKLE
AAIAEAEERGELALKDARAKQEELEAALQRGKQDMARQLREYQELMSVKLALDIEIATYRKLLEGEESRLAGDGVGAVNISVMNSTGGSS

--------------------------------------------------------------
>In-frame_ENST00000227451_ENST00000331817_TCGA-23-2081_DTX4_chr11_58949935_+_KRT7_chr12_52631292_length(transcript)=2074nt_BP=1039nt
GGCGCGGTCGAGGCCCGGAGGCGGCGGCGCAGGAGGAAGCGGAGGAGGTCGGGCGCTCGGGGCCCGGGAGGCGGGCCGCGCAGCGCCGCA
GCCCCGGGCTCGCCATGCTCCTGGCCTCGGCCGTGGTGGTCTGGGAATGGCTGAACGAGCACGGCCGCTGGCGTCCCTACAGCCCAGCGG
TGAGCCACCACATCGAGGCGGTGGTCCGCGCCGGCCCCCGCGCGGGGGGCAGCGTGGTGCTGGGCCAGGTGGACAGCCGTCTCGCGCCCT
ACATCATCGACCTGCAGTCCATGAACCAGTTCCGCCAAGACACGGGAACTCTCCGCCCAGTTCGCCGCAACTACTACGACCCCTCCTCGG
CCCCTGGGAAGGGCGTGGTGTGGGAGTGGGAGAACGACAATGGCTCCTGGACGCCCTACGACATGGAAGTGGGCATCACCATCCAGCATG
CCTATGAGAAGCAGCACCCCTGGATCGACCTCACTTCCATTGGCTTTAGCTACGTAATTGACTTCAACACCATGGGCCAGATCAACCGTC
AGACCCAGCGCCAACGCCGCGTCCGCCGGCGCCTCGACCTCATCTACCCCATGGTCACAGGGACCTTGCCTAAGGCTCAGTCCTGGCCAG
TCAGCCCTGGGCCAGCCACCTCGCCCCCCATGTCCCCCTGCTCCTGTCCCCAGTGTGTCTTGGTGATGAGTGTTAAGGCAGCCGTGGTCA
ATGGCAGCACTGGGCCCCTACAGCTGCCAGTGACCCGCAAGAACATGCCGCCTCCTGGAGTGGTCAAGCTACCCCCACTGCCAGGCTCTG
GGGCCAAGCCACTGGACAGCACAGGCACCATTCGAGGCCCACTGAAGACCGCCCCATCGCAGGTGATCCGGAGACAAGCCTCCAGCATGC
CCACTGGGACAACCATGGGCTCTCCTGCCAGTCCCCCAGGACCCAACAGCAAGACCGGAAGGGTGGCCCTGGCCACCTTGAATCGTACCA
ACCTGCAGCGACTGGCCATTGCCCAGTCCCGGGTGCTGATCGCCTCTGGGTACGAAGATGAAATTAACCACCGCACAGCTGCTGAGAATG
AGTTTGTGGTGCTGAAGAAGGATGTGGATGCTGCCTACATGAGCAAGGTGGAGCTGGAGGCCAAGGTGGATGCCCTGAATGATGAGATCA
ACTTCCTCAGGACCCTCAATGAGACGGAGTTGACAGAGCTGCAGTCCCAGATCTCCGACACATCTGTGGTGCTGTCCATGGACAACAGTC
GCTCCCTGGACCTGGACGGCATCATCGCTGAGGTCAAGGCGCAGTATGAGGAGATGGCCAAATGCAGCCGGGCTGAGGCTGAAGCCTGGT
ACCAGACCAAGTTTGAGACCCTCCAGGCCCAGGCTGGGAAGCATGGGGACGACCTCCGGAATACCCGGAATGAGATTTCAGAGATGAACC
GGGCCATCCAGAGGCTGCAGGCTGAGATCGACAACATCAAGAACCAGCGTGCCAAGTTGGAGGCCGCCATTGCCGAGGCTGAGGAGCGTG
GGGAGCTGGCGCTCAAGGATGCTCGTGCCAAGCAGGAGGAGCTGGAAGCCGCCCTGCAGCGGGGCAAGCAGGATATGGCACGGCAGCTGC
GTGAGTACCAGGAACTCATGAGCGTGAAGCTGGCCCTGGACATCGAGATCGCCACCTACCGCAAGCTGCTGGAGGGCGAGGAGAGCCGGT
TGGCTGGAGATGGAGTGGGAGCCGTGAATATCTCTGTGATGAATTCCACTGGTGGCAGTAGCAGTGGCGGTGGCATTGGGCTGACCCTCG
GGGGAACCATGGGCAGCAATGCCCTGAGCTTCTCCAGCAGTGCGGGTCCTGGGCTCCTGAAGGCTTATTCCATCCGGACCGCATCCGCCA
GTCGCAGGAGTGCCCGCGACTGAGCCGCCTCCCACCACTCCACTCCTCCAGCCACCACCCACAATCACAAGAAGATTCCCACCCCTGCCT
CCCATGCCTGGTCCCAAGACAGTGAGACAGTCTGGAAAGTGATGTCAGAATAGCTTCCAATAAAGCAGCCTCATTCTGAGGCCTGAGTGA

>In-frame_ENST00000227451_ENST00000331817_TCGA-23-2081_DTX4_chr11_58949935_+_KRT7_chr12_52631292_length(amino acids)=602AA_start in transcript=104_stop in transcript=1912
MLLASAVVVWEWLNEHGRWRPYSPAVSHHIEAVVRAGPRAGGSVVLGQVDSRLAPYIIDLQSMNQFRQDTGTLRPVRRNYYDPSSAPGKG
VVWEWENDNGSWTPYDMEVGITIQHAYEKQHPWIDLTSIGFSYVIDFNTMGQINRQTQRQRRVRRRLDLIYPMVTGTLPKAQSWPVSPGP
ATSPPMSPCSCPQCVLVMSVKAAVVNGSTGPLQLPVTRKNMPPPGVVKLPPLPGSGAKPLDSTGTIRGPLKTAPSQVIRRQASSMPTGTT
MGSPASPPGPNSKTGRVALATLNRTNLQRLAIAQSRVLIASGYEDEINHRTAAENEFVVLKKDVDAAYMSKVELEAKVDALNDEINFLRT
LNETELTELQSQISDTSVVLSMDNSRSLDLDGIIAEVKAQYEEMAKCSRAEAEAWYQTKFETLQAQAGKHGDDLRNTRNEISEMNRAIQR
LQAEIDNIKNQRAKLEAAIAEAEERGELALKDARAKQEELEAALQRGKQDMARQLREYQELMSVKLALDIEIATYRKLLEGEESRLAGDG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DTX4-KRT7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneKRT7chr11:58949935chr12:52631292ENST000003318171992_97178.66666666666666470.0HPV16 E7


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DTX4-KRT7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DTX4-KRT7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDTX4C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneDTX4C0887833Carcinoma, Pancreatic Ductal1CTD_human
TgeneKRT7C0007134Renal Cell Carcinoma2CTD_human
TgeneKRT7C0279702Conventional (Clear Cell) Renal Cell Carcinoma2CTD_human
TgeneKRT7C1266042Chromophobe Renal Cell Carcinoma2CTD_human
TgeneKRT7C1266043Sarcomatoid Renal Cell Carcinoma2CTD_human
TgeneKRT7C1266044Collecting Duct Carcinoma of the Kidney2CTD_human
TgeneKRT7C1306837Papillary Renal Cell Carcinoma2CTD_human
TgeneKRT7C0008312Primary biliary cirrhosis1CTD_human
TgeneKRT7C0019189Hepatitis, Chronic1CTD_human
TgeneKRT7C0023892Biliary cirrhosis1CTD_human
TgeneKRT7C0027626Neoplasm Invasiveness1CTD_human
TgeneKRT7C0149519Chronic Persistent Hepatitis1CTD_human
TgeneKRT7C0238065Secondary Biliary Cholangitis1CTD_human
TgeneKRT7C0520463Chronic active hepatitis1CTD_human
TgeneKRT7C0524611Cryptogenic Chronic Hepatitis1CTD_human
TgeneKRT7C0949541Hurthle Cell Tumor1CTD_human
TgeneKRT7C1510502Oxyphilic Adenoma1CTD_human
TgeneKRT7C1876165Copper-Overload Cirrhosis1CTD_human
TgeneKRT7C4551595Biliary Cirrhosis, Primary, 11CTD_human