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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DUSP22-PTK7 (FusionGDB2 ID:24474)

Fusion Gene Summary for DUSP22-PTK7

check button Fusion gene summary
Fusion gene informationFusion gene name: DUSP22-PTK7
Fusion gene ID: 24474
HgeneTgene
Gene symbol

DUSP22

PTK7

Gene ID

56940

5754

Gene namedual specificity phosphatase 22protein tyrosine kinase 7 (inactive)
SynonymsJKAP|JSP-1|JSP1|LMW-DSP2|LMWDSP2|MKP-x|MKPX|VHXCCK-4|CCK4
Cytomap

6p25.3

6p21.1

Type of geneprotein-codingprotein-coding
Descriptiondual specificity protein phosphatase 22JNK-stimulating phosphatase 1JNK-stimulatory phosphatase-1MAP kinase phosphatase xepididymis secretory sperm binding proteinhomolog of mouse dual specificity phosphatase LMW-DSP2low molecular weight dual specifinactive tyrosine-protein kinase 7PTK7 protein tyrosine kinase 7colon carcinoma kinase 4pseudo tyrosine kinase receptor 7tyrosine-protein kinase-like 7
Modification date2020031320200322
UniProtAcc

Q9NRW4

.
Ensembl transtripts involved in fusion geneENST00000344450, ENST00000603453, 
ENST00000605315, ENST00000419235, 
ENST00000605035, ENST00000605863, 
ENST00000603290, ENST00000604971, 
ENST00000230419, ENST00000349241, 
ENST00000345201, ENST00000352931, 
ENST00000481273, ENST00000476760, 
ENST00000471863, 
Fusion gene scores* DoF score5 X 3 X 5=759 X 9 X 4=324
# samples 510
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/324*10)=-1.6959938131099
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DUSP22 [Title/Abstract] AND PTK7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDUSP22(348841)-PTK7(43106587), # samples:3
Anticipated loss of major functional domain due to fusion event.DUSP22-PTK7 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
DUSP22-PTK7 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
DUSP22-PTK7 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneDUSP22

GO:0035335

peptidyl-tyrosine dephosphorylation

20018849

HgeneDUSP22

GO:0051895

negative regulation of focal adhesion assembly

20018849

HgeneDUSP22

GO:0071364

cellular response to epidermal growth factor stimulus

20018849


check buttonFusion gene breakpoints across DUSP22 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PTK7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-A65E-01ADUSP22chr6

348841

+PTK7chr6

43106587

+
ChimerDB4PRADTCGA-EJ-A65EDUSP22chr6

348841

+PTK7chr6

43106587

+
ChimerDB4PRADTCGA-EJ-A65E-01ADUSP22chr6

348841

-PTK7chr6

43106587

+


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Fusion Gene ORF analysis for DUSP22-PTK7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000344450ENST00000230419DUSP22chr6

348841

+PTK7chr6

43106587

+
5CDS-intronENST00000344450ENST00000349241DUSP22chr6

348841

+PTK7chr6

43106587

+
5CDS-intronENST00000344450ENST00000345201DUSP22chr6

348841

+PTK7chr6

43106587

+
5CDS-intronENST00000344450ENST00000352931DUSP22chr6

348841

+PTK7chr6

43106587

+
5CDS-intronENST00000344450ENST00000481273DUSP22chr6

348841

+PTK7chr6

43106587

+
5CDS-intronENST00000344450ENST00000476760DUSP22chr6

348841

+PTK7chr6

43106587

+
5CDS-intronENST00000344450ENST00000471863DUSP22chr6

348841

+PTK7chr6

43106587

+
Frame-shiftENST00000603453ENST00000230419DUSP22chr6

348841

+PTK7chr6

43106587

+
5CDS-intronENST00000603453ENST00000349241DUSP22chr6

348841

+PTK7chr6

43106587

+
5CDS-intronENST00000603453ENST00000345201DUSP22chr6

348841

+PTK7chr6

43106587

+
5CDS-intronENST00000603453ENST00000352931DUSP22chr6

348841

+PTK7chr6

43106587

+
5CDS-intronENST00000603453ENST00000481273DUSP22chr6

348841

+PTK7chr6

43106587

+
5CDS-intronENST00000603453ENST00000476760DUSP22chr6

348841

+PTK7chr6

43106587

+
5CDS-intronENST00000603453ENST00000471863DUSP22chr6

348841

+PTK7chr6

43106587

+
In-frameENST00000605315ENST00000230419DUSP22chr6

348841

+PTK7chr6

43106587

+
5CDS-intronENST00000605315ENST00000349241DUSP22chr6

348841

+PTK7chr6

43106587

+
5CDS-intronENST00000605315ENST00000345201DUSP22chr6

348841

+PTK7chr6

43106587

+
5CDS-intronENST00000605315ENST00000352931DUSP22chr6

348841

+PTK7chr6

43106587

+
5CDS-intronENST00000605315ENST00000481273DUSP22chr6

348841

+PTK7chr6

43106587

+
5CDS-intronENST00000605315ENST00000476760DUSP22chr6

348841

+PTK7chr6

43106587

+
5CDS-intronENST00000605315ENST00000471863DUSP22chr6

348841

+PTK7chr6

43106587

+
Frame-shiftENST00000419235ENST00000230419DUSP22chr6

348841

+PTK7chr6

43106587

+
5CDS-intronENST00000419235ENST00000349241DUSP22chr6

348841

+PTK7chr6

43106587

+
5CDS-intronENST00000419235ENST00000345201DUSP22chr6

348841

+PTK7chr6

43106587

+
5CDS-intronENST00000419235ENST00000352931DUSP22chr6

348841

+PTK7chr6

43106587

+
5CDS-intronENST00000419235ENST00000481273DUSP22chr6

348841

+PTK7chr6

43106587

+
5CDS-intronENST00000419235ENST00000476760DUSP22chr6

348841

+PTK7chr6

43106587

+
5CDS-intronENST00000419235ENST00000471863DUSP22chr6

348841

+PTK7chr6

43106587

+
3UTR-3CDSENST00000605035ENST00000230419DUSP22chr6

348841

+PTK7chr6

43106587

+
3UTR-intronENST00000605035ENST00000349241DUSP22chr6

348841

+PTK7chr6

43106587

+
3UTR-intronENST00000605035ENST00000345201DUSP22chr6

348841

+PTK7chr6

43106587

+
3UTR-intronENST00000605035ENST00000352931DUSP22chr6

348841

+PTK7chr6

43106587

+
3UTR-intronENST00000605035ENST00000481273DUSP22chr6

348841

+PTK7chr6

43106587

+
3UTR-intronENST00000605035ENST00000476760DUSP22chr6

348841

+PTK7chr6

43106587

+
3UTR-intronENST00000605035ENST00000471863DUSP22chr6

348841

+PTK7chr6

43106587

+
intron-3CDSENST00000605863ENST00000230419DUSP22chr6

348841

+PTK7chr6

43106587

+
intron-intronENST00000605863ENST00000349241DUSP22chr6

348841

+PTK7chr6

43106587

+
intron-intronENST00000605863ENST00000345201DUSP22chr6

348841

+PTK7chr6

43106587

+
intron-intronENST00000605863ENST00000352931DUSP22chr6

348841

+PTK7chr6

43106587

+
intron-intronENST00000605863ENST00000481273DUSP22chr6

348841

+PTK7chr6

43106587

+
intron-intronENST00000605863ENST00000476760DUSP22chr6

348841

+PTK7chr6

43106587

+
intron-intronENST00000605863ENST00000471863DUSP22chr6

348841

+PTK7chr6

43106587

+
intron-3CDSENST00000603290ENST00000230419DUSP22chr6

348841

+PTK7chr6

43106587

+
intron-intronENST00000603290ENST00000349241DUSP22chr6

348841

+PTK7chr6

43106587

+
intron-intronENST00000603290ENST00000345201DUSP22chr6

348841

+PTK7chr6

43106587

+
intron-intronENST00000603290ENST00000352931DUSP22chr6

348841

+PTK7chr6

43106587

+
intron-intronENST00000603290ENST00000481273DUSP22chr6

348841

+PTK7chr6

43106587

+
intron-intronENST00000603290ENST00000476760DUSP22chr6

348841

+PTK7chr6

43106587

+
intron-intronENST00000603290ENST00000471863DUSP22chr6

348841

+PTK7chr6

43106587

+
Frame-shiftENST00000604971ENST00000230419DUSP22chr6

348841

+PTK7chr6

43106587

+
5CDS-intronENST00000604971ENST00000349241DUSP22chr6

348841

+PTK7chr6

43106587

+
5CDS-intronENST00000604971ENST00000345201DUSP22chr6

348841

+PTK7chr6

43106587

+
5CDS-intronENST00000604971ENST00000352931DUSP22chr6

348841

+PTK7chr6

43106587

+
5CDS-intronENST00000604971ENST00000481273DUSP22chr6

348841

+PTK7chr6

43106587

+
5CDS-intronENST00000604971ENST00000476760DUSP22chr6

348841

+PTK7chr6

43106587

+
5CDS-intronENST00000604971ENST00000471863DUSP22chr6

348841

+PTK7chr6

43106587

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000344450DUSP22chr6348841+ENST00000230419PTK7chr643106587+37749514432935830
ENST00000605315DUSP22chr6348841+ENST00000230419PTK7chr643106587+36177948082778656

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000344450ENST00000230419DUSP22chr6348841+PTK7chr643106587+0.003567190.9964328
ENST00000605315ENST00000230419DUSP22chr6348841+PTK7chr643106587+0.0063341570.9936659

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Fusion Genomic Features for DUSP22-PTK7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
DUSP22chr6348841+PTK7chr643106586+4.99E-050.99995005
DUSP22chr6348841+PTK7chr643106586+4.99E-050.99995005
DUSP22chr6348841+PTK7chr643106586+4.99E-050.99995005
DUSP22chr6348841+PTK7chr643106586+4.99E-050.99995005

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for DUSP22-PTK7


check button Go to

FGviewer for the breakpoints of chr6:348841-chr6:43106587

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
DUSP22

Q9NRW4

.
FUNCTION: Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity). {ECO:0000250, ECO:0000269|PubMed:11717427}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDUSP22chr6:348841chr6:43106587ENST00000344450+784_144169.33333333333334185.0DomainTyrosine-protein phosphatase
TgenePTK7chr6:348841chr6:43106587ENST00000230419620412_497409.33333333333331071.0DomainNote=Ig-like C2-type 5
TgenePTK7chr6:348841chr6:43106587ENST00000230419620503_586409.33333333333331071.0DomainNote=Ig-like C2-type 6
TgenePTK7chr6:348841chr6:43106587ENST00000230419620578_680409.33333333333331071.0DomainNote=Ig-like C2-type 7
TgenePTK7chr6:348841chr6:43106587ENST00000230419620796_1066409.33333333333331071.0DomainProtein kinase%3B inactive
TgenePTK7chr6:348841chr6:43106587ENST00000345201619412_497409.33333333333331031.0DomainNote=Ig-like C2-type 5
TgenePTK7chr6:348841chr6:43106587ENST00000345201619503_586409.33333333333331031.0DomainNote=Ig-like C2-type 6
TgenePTK7chr6:348841chr6:43106587ENST00000345201619578_680409.33333333333331031.0DomainNote=Ig-like C2-type 7
TgenePTK7chr6:348841chr6:43106587ENST00000345201619796_1066409.33333333333331031.0DomainProtein kinase%3B inactive
TgenePTK7chr6:348841chr6:43106587ENST00000349241017128_2180941.0DomainNote=Ig-like C2-type 2
TgenePTK7chr6:348841chr6:43106587ENST00000349241017225_3170941.0DomainNote=Ig-like C2-type 3
TgenePTK7chr6:348841chr6:43106587ENST00000349241017309_4070941.0DomainNote=Ig-like C2-type 4
TgenePTK7chr6:348841chr6:43106587ENST0000034924101731_1200941.0DomainNote=Ig-like C2-type 1
TgenePTK7chr6:348841chr6:43106587ENST00000349241017412_4970941.0DomainNote=Ig-like C2-type 5
TgenePTK7chr6:348841chr6:43106587ENST00000349241017503_5860941.0DomainNote=Ig-like C2-type 6
TgenePTK7chr6:348841chr6:43106587ENST00000349241017578_6800941.0DomainNote=Ig-like C2-type 7
TgenePTK7chr6:348841chr6:43106587ENST00000349241017796_10660941.0DomainProtein kinase%3B inactive
TgenePTK7chr6:348841chr6:43106587ENST00000352931619412_497409.33333333333331015.0DomainNote=Ig-like C2-type 5
TgenePTK7chr6:348841chr6:43106587ENST00000352931619503_586409.33333333333331015.0DomainNote=Ig-like C2-type 6
TgenePTK7chr6:348841chr6:43106587ENST00000352931619578_680409.33333333333331015.0DomainNote=Ig-like C2-type 7
TgenePTK7chr6:348841chr6:43106587ENST00000352931619796_1066409.33333333333331015.0DomainProtein kinase%3B inactive
TgenePTK7chr6:348841chr6:43106587ENST00000481273620503_586417.33333333333331079.0DomainNote=Ig-like C2-type 6
TgenePTK7chr6:348841chr6:43106587ENST00000481273620578_680417.33333333333331079.0DomainNote=Ig-like C2-type 7
TgenePTK7chr6:348841chr6:43106587ENST00000481273620796_1066417.33333333333331079.0DomainProtein kinase%3B inactive
TgenePTK7chr6:348841chr6:43106587ENST00000230419620726_1070409.33333333333331071.0Topological domainCytoplasmic
TgenePTK7chr6:348841chr6:43106587ENST00000345201619726_1070409.33333333333331031.0Topological domainCytoplasmic
TgenePTK7chr6:348841chr6:43106587ENST0000034924101731_7040941.0Topological domainExtracellular
TgenePTK7chr6:348841chr6:43106587ENST00000349241017726_10700941.0Topological domainCytoplasmic
TgenePTK7chr6:348841chr6:43106587ENST00000352931619726_1070409.33333333333331015.0Topological domainCytoplasmic
TgenePTK7chr6:348841chr6:43106587ENST00000481273620726_1070417.33333333333331079.0Topological domainCytoplasmic
TgenePTK7chr6:348841chr6:43106587ENST00000230419620705_725409.33333333333331071.0TransmembraneHelical
TgenePTK7chr6:348841chr6:43106587ENST00000345201619705_725409.33333333333331031.0TransmembraneHelical
TgenePTK7chr6:348841chr6:43106587ENST00000349241017705_7250941.0TransmembraneHelical
TgenePTK7chr6:348841chr6:43106587ENST00000352931619705_725409.33333333333331015.0TransmembraneHelical
TgenePTK7chr6:348841chr6:43106587ENST00000481273620705_725417.33333333333331079.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDUSP22chr6:348841chr6:43106587ENST00000419235+174_1440206.0DomainTyrosine-protein phosphatase
TgenePTK7chr6:348841chr6:43106587ENST00000230419620128_218409.33333333333331071.0DomainNote=Ig-like C2-type 2
TgenePTK7chr6:348841chr6:43106587ENST00000230419620225_317409.33333333333331071.0DomainNote=Ig-like C2-type 3
TgenePTK7chr6:348841chr6:43106587ENST00000230419620309_407409.33333333333331071.0DomainNote=Ig-like C2-type 4
TgenePTK7chr6:348841chr6:43106587ENST0000023041962031_120409.33333333333331071.0DomainNote=Ig-like C2-type 1
TgenePTK7chr6:348841chr6:43106587ENST00000345201619128_218409.33333333333331031.0DomainNote=Ig-like C2-type 2
TgenePTK7chr6:348841chr6:43106587ENST00000345201619225_317409.33333333333331031.0DomainNote=Ig-like C2-type 3
TgenePTK7chr6:348841chr6:43106587ENST00000345201619309_407409.33333333333331031.0DomainNote=Ig-like C2-type 4
TgenePTK7chr6:348841chr6:43106587ENST0000034520161931_120409.33333333333331031.0DomainNote=Ig-like C2-type 1
TgenePTK7chr6:348841chr6:43106587ENST00000352931619128_218409.33333333333331015.0DomainNote=Ig-like C2-type 2
TgenePTK7chr6:348841chr6:43106587ENST00000352931619225_317409.33333333333331015.0DomainNote=Ig-like C2-type 3
TgenePTK7chr6:348841chr6:43106587ENST00000352931619309_407409.33333333333331015.0DomainNote=Ig-like C2-type 4
TgenePTK7chr6:348841chr6:43106587ENST0000035293161931_120409.33333333333331015.0DomainNote=Ig-like C2-type 1
TgenePTK7chr6:348841chr6:43106587ENST00000481273620128_218417.33333333333331079.0DomainNote=Ig-like C2-type 2
TgenePTK7chr6:348841chr6:43106587ENST00000481273620225_317417.33333333333331079.0DomainNote=Ig-like C2-type 3
TgenePTK7chr6:348841chr6:43106587ENST00000481273620309_407417.33333333333331079.0DomainNote=Ig-like C2-type 4
TgenePTK7chr6:348841chr6:43106587ENST0000048127362031_120417.33333333333331079.0DomainNote=Ig-like C2-type 1
TgenePTK7chr6:348841chr6:43106587ENST00000481273620412_497417.33333333333331079.0DomainNote=Ig-like C2-type 5
TgenePTK7chr6:348841chr6:43106587ENST0000023041962031_704409.33333333333331071.0Topological domainExtracellular
TgenePTK7chr6:348841chr6:43106587ENST0000034520161931_704409.33333333333331031.0Topological domainExtracellular
TgenePTK7chr6:348841chr6:43106587ENST0000035293161931_704409.33333333333331015.0Topological domainExtracellular
TgenePTK7chr6:348841chr6:43106587ENST0000048127362031_704417.33333333333331079.0Topological domainExtracellular


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Fusion Gene Sequence for DUSP22-PTK7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000344450_ENST00000230419_TCGA-EJ-A65E-01A_DUSP22_chr6_348841_+_PTK7_chr6_43106587_length(transcript)=3774nt_BP=951nt
GAGCCCGAGCCTAGTGCCTCCCACGCCCGGCGGCCGCGAGCCGGGGTCCGCGAGGGCGGAGTGGGGCGCGGCAGCCAGGAACCCGACTAC
GAATCCCAGGGTGCGGGCGGGCGGAGCGAGGAGGGACGCTGGGCCTGCCCGGTGCGCACGGGGGCGGGGACCGGCAAGGCGGGACCATTT
CCCGGCATAGGCTCCGGTGCCCCTGCCCGGCTCCCGCCGGGAAGTTCTAGGCCGCCGCACAGAAAGCCCTGCCCTCCACGCCGGGTCTCT
GGAGCGCCCTGGGTTGCCCGGCCGGTCCCTGCCGCTGACTTGTTGACACTGCGAGCACTCAGTCCCTCCCGCGCGCCTCCTCCCCGCCCG
CCCCGCCGCTCCTCCTCCCTGTAACATGCCATAGTGCGCCTGCGACCACACGGCCGGGGCGCTAGCGTTCGCCTTCAGCCACCATGGGGA
ATGGGATGAACAAGATCCTGCCCGGCCTGTACATCGGCAACTTCAAAGATGCCAGAGACGCGGAACAATTGAGCAAGAACAAGGTGACAC
ATATTCTGTCTGTCCACGATAGTGCCAGGCCTATGTTGGAGGGAGTTAAATACCTGTGCATCCCAGCAGCGGATTCACCATCTCAAAACC
TGACAAGACATTTCAAAGAAAGTATTAAATTCATTCACGAGTGCCGGCTCCGCGGTGAGAGCTGCCTTGTACACTGCCTGGCCGGGGTCT
CCAGGAGCGTGACACTGGTGATCGCATACATCATGACCGTCACTGACTTTGGCTGGGAGGATGCCCTGCACACCGTGCGTGCTGGGAGAT
CCTGTGCCAACCCCAACGTGGGCTTCCAGAGACAGCTCCAGGAGTTTGAGAAGCATGAGGTCCATCAGTATCGGCAGTGGCTGAAGGAAG
AATATGGAGAGAGCCCTTTGCAGGATGCAGAAGAAGCCAAAAACATTCTGGCTGTGCCCTCCTGGCTGAAGAAGCCCCAAGACAGCCAGC
TGGAGGAGGGCAAACCCGGCTACTTGGATTGCCTGACCCAGGCCACACCAAAACCTACAGTTGTCTGGTACAGAAACCAGATGCTCATCT
CAGAGGACTCACGGTTCGAGGTCTTCAAGAATGGGACCTTGCGCATCAACAGCGTGGAGGTGTATGATGGGACATGGTACCGTTGTATGA
GCAGCACCCCAGCCGGCAGCATCGAGGCGCAAGCCCGTGTCCAAGTGCTGGAAAAGCTCAAGTTCACACCACCACCCCAGCCACAGCAGT
GCATGGAGTTTGACAAGGAGGCCACGGTGCCCTGTTCAGCCACAGGCCGAGAGAAGCCCACTATTAAGTGGGAACGGGCAGATGGGAGCA
GCCTCCCAGAGTGGGTGACAGACAACGCTGGGACCCTGCATTTTGCCCGGGTGACTCGAGATGACGCTGGCAACTACACTTGCATTGCCT
CCAACGGGCCGCAGGGCCAGATTCGTGCCCATGTCCAGCTCACTGTGGCAGTTTTTATCACCTTCAAAGTGGAACCAGAGCGTACGACTG
TGTACCAGGGCCACACAGCCCTACTGCAGTGCGAGGCCCAGGGGGACCCCAAGCCGCTGATTCAGTGGAAAGGCAAGGACCGCATCCTGG
ACCCCACCAAGCTGGGACCCAGGATGCACATCTTCCAGAATGGCTCCCTGGTGATCCATGACGTGGCCCCTGAGGACTCAGGCCGCTACA
CCTGCATTGCAGGCAACAGCTGCAACATCAAGCACACGGAGGCCCCCCTCTATGTCGTGGACAAGCCTGTGCCGGAGGAGTCGGAGGGCC
CTGGCAGCCCTCCCCCCTACAAGATGATCCAGACCATTGGGTTGTCGGTGGGTGCCGCTGTGGCCTACATCATTGCCGTGCTGGGCCTCA
TGTTCTACTGCAAGAAGCGCTGCAAAGCCAAGCGGCTGCAGAAGCAGCCCGAGGGCGAGGAGCCAGAGATGGAATGCCTCAACGGTGGGC
CTTTGCAGAACGGGCAGCCCTCAGCAGAGATCCAAGAAGAAGTGGCCTTGACCAGCTTGGGCTCCGGCCCCGCGGCCACCAACAAACGCC
ACAGCACAAGTGATAAGATGCACTTCCCACGGTCTAGCCTGCAGCCCATCACCACGCTGGGGAAGAGTGAGTTTGGGGAGGTGTTCCTGG
CAAAGGCTCAGGGCTTGGAGGAGGGAGTGGCAGAGACCCTGGTACTTGTGAAGAGCCTGCAGAGCAAGGATGAGCAGCAGCAGCTGGACT
TCCGGAGGGAGTTGGAGATGTTTGGGAAGCTGAACCACGCCAACGTGGTGCGGCTCCTGGGGCTGTGCCGGGAGGCTGAGCCCCACTACA
TGGTGCTGGAATATGTGGATCTGGGAGACCTCAAGCAGTTCCTGAGGATTTCCAAGAGCAAGGATGAAAAATTGAAGTCACAGCCCCTCA
GCACCAAGCAGAAGGTGGCCCTATGCACCCAGGTAGCCCTGGGCATGGAGCACCTGTCCAACAACCGCTTTGTGCATAAGGACTTGGCTG
CGCGTAACTGCCTGGTCAGTGCCCAGAGACAAGTGAAGGTGTCTGCCCTGGGCCTCAGCAAGGATGTGTACAACAGTGAGTACTACCACT
TCCGCCAGGCCTGGGTGCCGCTGCGCTGGATGTCCCCCGAGGCCATCCTGGAGGGTGACTTCTCTACCAAGTCTGATGTCTGGGCCTTCG
GTGTGCTGATGTGGGAAGTGTTTACACATGGAGAGATGCCCCATGGTGGGCAGGCAGATGATGAAGTACTGGCAGATTTGCAGGCTGGGA
AGGCTAGACTTCCTCAGCCCGAGGGCTGCCCTTCCAAACTCTATCGGCTGATGCAGCGCTGCTGGGCCCTCAGCCCCAAGGACCGGCCCT
CCTTCAGTGAGATTGCCAGCGCCCTGGGAGACAGCACCGTGGACAGCAAGCCGTGAGGAGGGAGCCCGCTCAGGATGGCCTGGGCAGGGG
AGGACATCTCTAGAGGGAAGCTCACAGCATGATGGGCAAGATCCCTGTCCTCCTGGGCCCTGAGGCCCCTGCCCTAGTGCAACAGGCATT
GCTGAGGTCTGAGCAGGGCCTGGCCTTTCCTCCTCTTCCTCACCCTCATCCTTTGGGAGGCTGACTTGGACCCAAACTGGGCGACTAGGG
CTTTGAGCTGGGCAGTTTTCCCTGCCACCTCTTCCTCTATCAGGGACAGTGTGGGTGCCACAGGTAACCCCAATTTCTGGCCTTCAACTT
CTCCCCTTGACCGGGTCCAACTCTGCCACTCATCTGCCAACTTTGCCTGGGGAGGGCTAGGCTTGGGATGAGCTGGGTTTGTGGGGAGTT
CCTTAATATTCTCAAGTTCTGGGCACACAGGGTTAATGAGTCTCTTGGCCCACTGGTCCCACTTGGGGGTCTAGACCAGGATTATAGAGG
ACACAGCAAGTGAGTCCTCCCCACTCTGGGCTTGTGCACACTGACCCAGACCCACGTCTTCCCCACCCTTCTCTCCTTTCCTCATCCTAA
GTGCCTGGCAGATGAAGGAGTTTTCAGGAGCTTTTGACACTATATAAACCGCCCTTTTTGTATGCACCACGGGCGGCTTTTATATGTAAT
TGCAGCGTGGGGTGGGTGGGCATGGGAGGTAGGGGTGGGCCCTGGAGATGAGGAGGGTGGGCCATCCTTACCCCACACTTTTATTGTTGT

>In-frame_ENST00000344450_ENST00000230419_TCGA-EJ-A65E-01A_DUSP22_chr6_348841_+_PTK7_chr6_43106587_length(amino acids)=830AA_start in transcript=443_stop in transcript=2935
MGNGMNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLEGVKYLCIPAADSPSQNLTRHFKESIKFIHECRLRGESCLVHCLA
GVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNVGFQRQLQEFEKHEVHQYRQWLKEEYGESPLQDAEEAKNILAVPSWLKKPQD
SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPPQP
QQCMEFDKEATVPCSATGREKPTIKWERADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER
TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEES
EGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN
KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEP
HYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY
YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKD

--------------------------------------------------------------
>In-frame_ENST00000605315_ENST00000230419_TCGA-EJ-A65E-01A_DUSP22_chr6_348841_+_PTK7_chr6_43106587_length(transcript)=3617nt_BP=794nt
TTCCCGGCATAGGCTCCGGTGCCCCTGCCCGGCTCCCGCCGGGAAGTTCTAGGCCGCCGCACAGAAAGCCCTGCCCTCCACGCCGGGTCT
CTGGAGCGCCCTGGGTTGCCCGGCCGGTCCCTGCCGCTGACTTGTTGACACTGCGAGCACTCAGTCCCTCCCGCGCGCCTCCTCCCCGCC
CGCCCCGCCGCTCCTCCTCCCTGTAACATGCCATAGTGCGCCTGCGACCACACGGCCGGGGCGCTAGCGTTCGCCTTCAGCCACCATGGG
GAATGGGATGAACAAGGACAAGACATTTCAAAGAAAGTATTAAATTCATTCACGAGTGCCGGCTCCGCGGTGAGAGCTGCCTTGTACACT
GCCTGGCCGGGGTCTCCAGGAGCGTGACACTGGTGATCGCATACATCATGACCGTCACTGACTTTGGCTGGGAGGATGCCCTGCACACCG
TGCGTGCTGGGAGATCCTGTGCCAACCCCAACGTGGGCTTCCAGAGACAGCTCCAGGAGTTTGAGAAGCATGAGGTCCATCAGGTAAATA
TAAGGAGCAAGGGCGCACAGAGCCCCAGCCCGGCGCCAGGCGGTGGAGCAGTTTTCCGGCACTGGCTCCGCTGACCTACGATAATTATAC
GACGGAGACCTAACGCAAGCGACCTGCTGCCTTCCTTCCCACTGCTTGTCTTCAGTGTGCCCGGCTGGGCAGGGGTGCGGTGGTGGTGGC
CGATGAGGACAGGAAAGGGAGATAGCCAGGGCGAGGTGGGGCGAGGGCTCCTTCCCCCAAGCAACACCGCCCAGCTGTGCCCTCCTGGCT
GAAGAAGCCCCAAGACAGCCAGCTGGAGGAGGGCAAACCCGGCTACTTGGATTGCCTGACCCAGGCCACACCAAAACCTACAGTTGTCTG
GTACAGAAACCAGATGCTCATCTCAGAGGACTCACGGTTCGAGGTCTTCAAGAATGGGACCTTGCGCATCAACAGCGTGGAGGTGTATGA
TGGGACATGGTACCGTTGTATGAGCAGCACCCCAGCCGGCAGCATCGAGGCGCAAGCCCGTGTCCAAGTGCTGGAAAAGCTCAAGTTCAC
ACCACCACCCCAGCCACAGCAGTGCATGGAGTTTGACAAGGAGGCCACGGTGCCCTGTTCAGCCACAGGCCGAGAGAAGCCCACTATTAA
GTGGGAACGGGCAGATGGGAGCAGCCTCCCAGAGTGGGTGACAGACAACGCTGGGACCCTGCATTTTGCCCGGGTGACTCGAGATGACGC
TGGCAACTACACTTGCATTGCCTCCAACGGGCCGCAGGGCCAGATTCGTGCCCATGTCCAGCTCACTGTGGCAGTTTTTATCACCTTCAA
AGTGGAACCAGAGCGTACGACTGTGTACCAGGGCCACACAGCCCTACTGCAGTGCGAGGCCCAGGGGGACCCCAAGCCGCTGATTCAGTG
GAAAGGCAAGGACCGCATCCTGGACCCCACCAAGCTGGGACCCAGGATGCACATCTTCCAGAATGGCTCCCTGGTGATCCATGACGTGGC
CCCTGAGGACTCAGGCCGCTACACCTGCATTGCAGGCAACAGCTGCAACATCAAGCACACGGAGGCCCCCCTCTATGTCGTGGACAAGCC
TGTGCCGGAGGAGTCGGAGGGCCCTGGCAGCCCTCCCCCCTACAAGATGATCCAGACCATTGGGTTGTCGGTGGGTGCCGCTGTGGCCTA
CATCATTGCCGTGCTGGGCCTCATGTTCTACTGCAAGAAGCGCTGCAAAGCCAAGCGGCTGCAGAAGCAGCCCGAGGGCGAGGAGCCAGA
GATGGAATGCCTCAACGGTGGGCCTTTGCAGAACGGGCAGCCCTCAGCAGAGATCCAAGAAGAAGTGGCCTTGACCAGCTTGGGCTCCGG
CCCCGCGGCCACCAACAAACGCCACAGCACAAGTGATAAGATGCACTTCCCACGGTCTAGCCTGCAGCCCATCACCACGCTGGGGAAGAG
TGAGTTTGGGGAGGTGTTCCTGGCAAAGGCTCAGGGCTTGGAGGAGGGAGTGGCAGAGACCCTGGTACTTGTGAAGAGCCTGCAGAGCAA
GGATGAGCAGCAGCAGCTGGACTTCCGGAGGGAGTTGGAGATGTTTGGGAAGCTGAACCACGCCAACGTGGTGCGGCTCCTGGGGCTGTG
CCGGGAGGCTGAGCCCCACTACATGGTGCTGGAATATGTGGATCTGGGAGACCTCAAGCAGTTCCTGAGGATTTCCAAGAGCAAGGATGA
AAAATTGAAGTCACAGCCCCTCAGCACCAAGCAGAAGGTGGCCCTATGCACCCAGGTAGCCCTGGGCATGGAGCACCTGTCCAACAACCG
CTTTGTGCATAAGGACTTGGCTGCGCGTAACTGCCTGGTCAGTGCCCAGAGACAAGTGAAGGTGTCTGCCCTGGGCCTCAGCAAGGATGT
GTACAACAGTGAGTACTACCACTTCCGCCAGGCCTGGGTGCCGCTGCGCTGGATGTCCCCCGAGGCCATCCTGGAGGGTGACTTCTCTAC
CAAGTCTGATGTCTGGGCCTTCGGTGTGCTGATGTGGGAAGTGTTTACACATGGAGAGATGCCCCATGGTGGGCAGGCAGATGATGAAGT
ACTGGCAGATTTGCAGGCTGGGAAGGCTAGACTTCCTCAGCCCGAGGGCTGCCCTTCCAAACTCTATCGGCTGATGCAGCGCTGCTGGGC
CCTCAGCCCCAAGGACCGGCCCTCCTTCAGTGAGATTGCCAGCGCCCTGGGAGACAGCACCGTGGACAGCAAGCCGTGAGGAGGGAGCCC
GCTCAGGATGGCCTGGGCAGGGGAGGACATCTCTAGAGGGAAGCTCACAGCATGATGGGCAAGATCCCTGTCCTCCTGGGCCCTGAGGCC
CCTGCCCTAGTGCAACAGGCATTGCTGAGGTCTGAGCAGGGCCTGGCCTTTCCTCCTCTTCCTCACCCTCATCCTTTGGGAGGCTGACTT
GGACCCAAACTGGGCGACTAGGGCTTTGAGCTGGGCAGTTTTCCCTGCCACCTCTTCCTCTATCAGGGACAGTGTGGGTGCCACAGGTAA
CCCCAATTTCTGGCCTTCAACTTCTCCCCTTGACCGGGTCCAACTCTGCCACTCATCTGCCAACTTTGCCTGGGGAGGGCTAGGCTTGGG
ATGAGCTGGGTTTGTGGGGAGTTCCTTAATATTCTCAAGTTCTGGGCACACAGGGTTAATGAGTCTCTTGGCCCACTGGTCCCACTTGGG
GGTCTAGACCAGGATTATAGAGGACACAGCAAGTGAGTCCTCCCCACTCTGGGCTTGTGCACACTGACCCAGACCCACGTCTTCCCCACC
CTTCTCTCCTTTCCTCATCCTAAGTGCCTGGCAGATGAAGGAGTTTTCAGGAGCTTTTGACACTATATAAACCGCCCTTTTTGTATGCAC
CACGGGCGGCTTTTATATGTAATTGCAGCGTGGGGTGGGTGGGCATGGGAGGTAGGGGTGGGCCCTGGAGATGAGGAGGGTGGGCCATCC
TTACCCCACACTTTTATTGTTGTCGTTTTTTGTTTGTTTTGTTTTTTTGTTTTTGTTTTTGTTTTTACACTCGCTGCTCTCAATAAATAA

>In-frame_ENST00000605315_ENST00000230419_TCGA-EJ-A65E-01A_DUSP22_chr6_348841_+_PTK7_chr6_43106587_length(amino acids)=656AA_start in transcript=808_stop in transcript=2778
MKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKF
TPPPQPQQCMEFDKEATVPCSATGREKPTIKWERADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITF
KVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDK
PVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGS
GPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGL
CREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKD
VYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCW

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DUSP22-PTK7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgenePTK7chr6:348841chr6:43106587ENST00000230419620794_1070409.33333333333331071.0CTNNB1
TgenePTK7chr6:348841chr6:43106587ENST00000345201619794_1070409.33333333333331031.0CTNNB1
TgenePTK7chr6:348841chr6:43106587ENST00000349241017794_10700941.0CTNNB1
TgenePTK7chr6:348841chr6:43106587ENST00000352931619794_1070409.33333333333331015.0CTNNB1
TgenePTK7chr6:348841chr6:43106587ENST00000481273620794_1070417.33333333333331079.0CTNNB1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DUSP22-PTK7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DUSP22-PTK7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePTK7C1535926Neurodevelopmental Disorders1CTD_human