FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:EBNA1BP2-FMO3 (FusionGDB2 ID:24812)

Fusion Gene Summary for EBNA1BP2-FMO3

check button Fusion gene summary
Fusion gene informationFusion gene name: EBNA1BP2-FMO3
Fusion gene ID: 24812
HgeneTgene
Gene symbol

EBNA1BP2

FMO3

Gene ID

10969

2328

Gene nameEBNA1 binding protein 2flavin containing dimethylaniline monoxygenase 3
SynonymsEBP2|NOBP|P40FMOII|TMAU|dJ127D3.1
Cytomap

1p34.2

1q24.3

Type of geneprotein-codingprotein-coding
Descriptionprobable rRNA-processing protein EBP2nuclear FGF3 binding proteinnucleolar protein p40nucleolar protein p40; homolog of yeast EBNA1-binding proteindimethylaniline monooxygenase [N-oxide-forming] 3FMO form 2dimethylaniline oxidase 3flavin containing monooxygenase 3hepatic flavin-containing monooxygenase-3trimethylamine monooxygenase
Modification date2020031320200313
UniProtAcc

Q99848

P31513

Ensembl transtripts involved in fusion geneENST00000431635, ENST00000236051, 
ENST00000472982, 		ENST00000392085, 
ENST00000367755, ENST00000542847, 
ENST00000534514, ENST00000538429, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 5 X 3=45
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/45*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EBNA1BP2 [Title/Abstract] AND FMO3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEBNA1BP2(43634610)-FMO3(171072926), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across EBNA1BP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FMO3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-EP-A3RK-01AEBNA1BP2chr1

43634610

-FMO3chr1

171072926

+


Top

Fusion Gene ORF analysis for EBNA1BP2-FMO3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000431635ENST00000392085EBNA1BP2chr1

43634610

-FMO3chr1

171072926

+
In-frameENST00000431635ENST00000367755EBNA1BP2chr1

43634610

-FMO3chr1

171072926

+
In-frameENST00000431635ENST00000542847EBNA1BP2chr1

43634610

-FMO3chr1

171072926

+
5CDS-intronENST00000431635ENST00000534514EBNA1BP2chr1

43634610

-FMO3chr1

171072926

+
5CDS-intronENST00000431635ENST00000538429EBNA1BP2chr1

43634610

-FMO3chr1

171072926

+
In-frameENST00000236051ENST00000392085EBNA1BP2chr1

43634610

-FMO3chr1

171072926

+
In-frameENST00000236051ENST00000367755EBNA1BP2chr1

43634610

-FMO3chr1

171072926

+
In-frameENST00000236051ENST00000542847EBNA1BP2chr1

43634610

-FMO3chr1

171072926

+
5CDS-intronENST00000236051ENST00000534514EBNA1BP2chr1

43634610

-FMO3chr1

171072926

+
5CDS-intronENST00000236051ENST00000538429EBNA1BP2chr1

43634610

-FMO3chr1

171072926

+
intron-3CDSENST00000472982ENST00000392085EBNA1BP2chr1

43634610

-FMO3chr1

171072926

+
intron-3CDSENST00000472982ENST00000367755EBNA1BP2chr1

43634610

-FMO3chr1

171072926

+
intron-3CDSENST00000472982ENST00000542847EBNA1BP2chr1

43634610

-FMO3chr1

171072926

+
intron-intronENST00000472982ENST00000534514EBNA1BP2chr1

43634610

-FMO3chr1

171072926

+
intron-intronENST00000472982ENST00000538429EBNA1BP2chr1

43634610

-FMO3chr1

171072926

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000431635EBNA1BP2chr143634610-ENST00000392085FMO3chr1171072926+2691851502317755
ENST00000431635EBNA1BP2chr143634610-ENST00000367755FMO3chr1171072926+2695851502317755
ENST00000431635EBNA1BP2chr143634610-ENST00000542847FMO3chr1171072926+2343851502317755
ENST00000236051EBNA1BP2chr143634610-ENST00000392085FMO3chr1171072926+25196791422145667
ENST00000236051EBNA1BP2chr143634610-ENST00000367755FMO3chr1171072926+25236791422145667
ENST00000236051EBNA1BP2chr143634610-ENST00000542847FMO3chr1171072926+21716791422145667

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000431635ENST00000392085EBNA1BP2chr143634610-FMO3chr1171072926+0.0017889550.998211
ENST00000431635ENST00000367755EBNA1BP2chr143634610-FMO3chr1171072926+0.0017346490.9982653
ENST00000431635ENST00000542847EBNA1BP2chr143634610-FMO3chr1171072926+0.0024465730.9975534
ENST00000236051ENST00000392085EBNA1BP2chr143634610-FMO3chr1171072926+0.0014751660.99852484
ENST00000236051ENST00000367755EBNA1BP2chr143634610-FMO3chr1171072926+0.0014287260.9985713
ENST00000236051ENST00000542847EBNA1BP2chr143634610-FMO3chr1171072926+0.0022775990.99772245

Top

Fusion Genomic Features for EBNA1BP2-FMO3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
EBNA1BP2chr143634609-FMO3chr1171072925+0.0173574370.98264253
EBNA1BP2chr143634609-FMO3chr1171072925+0.0173574370.98264253

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for EBNA1BP2-FMO3


check button Go to

FGviewer for the breakpoints of chr1:43634610-chr1:171072926

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EBNA1BP2

Q99848

FMO3

P31513

FUNCTION: Required for the processing of the 27S pre-rRNA. {ECO:0000250}.FUNCTION: Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds (PubMed:10759686, PubMed:30381441). Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite (PubMed:9776311). TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation (PubMed:29981269). {ECO:0000250|UniProtKB:P97501, ECO:0000269|PubMed:10759686, ECO:0000269|PubMed:29981269, ECO:0000269|PubMed:30381441, ECO:0000269|PubMed:9224773, ECO:0000269|PubMed:9776311}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEBNA1BP2chr1:43634610chr1:171072926ENST00000236051-59138_169179.0307.0Coiled coilOntology_term=ECO:0000255
TgeneFMO3chr1:43634610chr1:171072926ENST0000036775519195_19844.0533.0Nucleotide bindingNADP
TgeneFMO3chr1:43634610chr1:171072926ENST000003677551960_6144.0533.0Nucleotide bindingNADP
TgeneFMO3chr1:43634610chr1:171072926ENST000003677551961_6244.0533.0Nucleotide bindingFAD
TgeneFMO3chr1:43634610chr1:171072926ENST0000039208519195_19844.0533.0Nucleotide bindingNADP
TgeneFMO3chr1:43634610chr1:171072926ENST000003920851960_6144.0533.0Nucleotide bindingNADP
TgeneFMO3chr1:43634610chr1:171072926ENST000003920851961_6244.0533.0Nucleotide bindingFAD
TgeneFMO3chr1:43634610chr1:171072926ENST0000036775519510_53044.0533.0TransmembraneHelical
TgeneFMO3chr1:43634610chr1:171072926ENST0000039208519510_53044.0533.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFMO3chr1:43634610chr1:171072926ENST000003677551940_4144.0533.0Nucleotide bindingFAD
TgeneFMO3chr1:43634610chr1:171072926ENST00000367755199_1344.0533.0Nucleotide bindingFAD
TgeneFMO3chr1:43634610chr1:171072926ENST000003920851940_4144.0533.0Nucleotide bindingFAD
TgeneFMO3chr1:43634610chr1:171072926ENST00000392085199_1344.0533.0Nucleotide bindingFAD


Top

Fusion Gene Sequence for EBNA1BP2-FMO3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000431635_ENST00000392085_TCGA-EP-A3RK-01A_EBNA1BP2_chr1_43634610_-_FMO3_chr1_171072926_length(transcript)=2691nt_BP=851nt
CCTCCCCCGGGGTCCTCCTCCGCGCCACCCCACCCCCGCGGCTCCTTTTTCTGCCTTTTCCTTTGTACCCTCACTGCTACCAGCTCCTTC
TGGCGACCCCCAGGTACCCCCTCCCACCTTTCGTTTCTCTCTGGGTCAGCAGACCACGCATGTATCCAGAGGCGCTACCTGTAGGGATCC
TAAGCAACCCGGACACTTTCAAACGCCGTAGCGGTTCCTATAGCAACGACAAACCGGAAGTATGGTTTGCCGCCGGAAGCGGAAGTCCCA
ATCAAAAGTTGAGCAGTAGCTGTGTGGGACGTGCGTGCGGCGAGATGGACACTCCCCCGCTCTCGGATTCGGAGTCGGAATCCGATGAAT
CCCTTGTCACAGACAGAGAGTTGCAGGATGCGTTTTCCCGAGGGCTTCTGAAGCCAGGCCTCAATGTCGTGCTAGAGGGGCCGAAGAAGG
CCGTGAACGACGTGAATGGCCTGAAGCAATGTTTGGCAGAATTCAAGCGGGATCTGGAATGGGTTGAAAGGCTCGATGTGACACTGGGTC
CGGTACCGGAGATCGGTGGATCTGAGGCGCCAGCACCTCAGAACAAGGACCAGAAAGCTGTTGATCCAGAAGACGACTTCCAGCGAGAGA
TGAGTTTCTATCGCCAAGCCCAGGCCGCAGTGCTTGCAGTCTTACCCCGCCTCCATCAGCTCAAAGTCCCTACGAAGCGACCCACTGATT
ATTTTGCGGAAATGGCCAAATCTGATCTGCAGATGCAGAAGATTCGACAGAAGCTGCAGACTAAACAGGCTGCCATGGAGAGGTCTGAAA
AAGCTAAGCAACTGCGAGCACTTAGGAAATACGGGAAGAAGGACCATGCAGAGGAGGGCAGGGCTAGCATTTACAAATCAGTCTTTTCCA
ACTCTTCCAAAGAGATGATGTGTTTCCCAGACTTCCCATTTCCCGATGACTTCCCCAACTTTATGCACAACAGCAAGATCCAGGAATATA
TCATTGCATTTGCCAAAGAAAAGAACCTCCTGAAGTACATACAATTTAAGACATTTGTATCCAGTGTAAATAAACATCCTGATTTTGCAA
CTACTGGCCAGTGGGATGTTACCACTGAAAGGGATGGTAAAAAAGAATCGGCTGTCTTTGATGCTGTAATGGTTTGTTCCGGACATCATG
TGTATCCCAACCTACCAAAAGAGTCCTTTCCAGGACTAAACCACTTTAAAGGCAAATGCTTCCACAGCAGGGACTATAAAGAACCAGGTG
TATTCAATGGAAAGCGTGTCCTGGTGGTTGGCCTGGGGAATTCGGGCTGTGATATTGCCACAGAACTCAGCCGCACAGCAGAACAGGTCA
TGATCAGTTCCAGAAGTGGCTCCTGGGTGATGAGCCGGGTCTGGGACAATGGTTATCCTTGGGACATGCTGCTCGTCACTCGATTTGGAA
CCTTCCTCAAGAACAATTTACCGACAGCCATCTCTGACTGGTTGTACGTGAAGCAGATGAATGCAAGATTCAAGCATGAAAACTATGGCT
TGATGCCTTTAAATGGAGTCCTGAGGAAAGAGCCTGTATTTAACGATGAGCTCCCAGCAAGCATTCTGTGTGGCATTGTGTCCGTAAAGC
CTAACGTGAAGGAATTCACAGAGACCTCGGCCATTTTTGAGGATGGGACCATATTTGAGGGCATTGACTGTGTAATCTTTGCAACAGGGT
ATAGTTTTGCCTACCCCTTCCTTGATGAGTCTATCATCAAAAGCAGAAACAATGAGATCATTTTATTTAAAGGAGTATTTCCTCCTCTAC
TTGAGAAGTCAACCATAGCAGTGATTGGCTTTGTCCAGTCCCTTGGGGCTGCCATTCCCACAGTTGACCTCCAGTCCCGCTGGGCAGCAC
AAGTAATAAAGGGAACTTGTACTTTGCCTTCTATGGAAGACATGATGAATGATATTAATGAGAAAATGGAGAAAAAGCGCAAATGGTTTG
GCAAAAGCGAGACCATACAGACAGATTACATTGTTTATATGGATGAACTCTCCTCCTTCATTGGGGCAAAGCCCAACATCCCATGGCTGT
TTCTCACAGATCCCAAATTGGCCATGGAAGTTTATTTTGGCCCTTGTAGTCCCTACCAGTTTAGGCTGGTGGGCCCAGGGCAGTGGCCAG
GAGCCAGAAATGCCATACTGACCCAGTGGGACCGGTCGTTGAAACCCATGCAGACACGAGTGGTCGGGAGACTTCAGAAGCCTTGCTTCT
TTTTCCATTGGCTGAAGCTCTTTGCAATTCCTATTCTGTTAATCGCTGTTTTCCTTGTGTTGACCTAATCATCATTTTCTCTAGGATTTC
TGAAAGTTACTGACAATACCCAGACAGGGGCTTTGCTATTTAAAAATTAAAATTTTCACACCACCTGCTTTTCTATTCAGCATCTTTTGC
AGTACTCTGTAGACATTAGTCAGTAATACAGTGTTATTTCTAGGCTCTGAAATAGCCACTTTAAGAATCATGTCATGATCTTAAGAGAGC
ACTAATCATTTCTGTTTGAGTTCCACTAACACTTCAAAATCAGAACTATGTTCTTTATATCTAACTTAAATCATTTCCTGAAACATTTTG

>In-frame_ENST00000431635_ENST00000392085_TCGA-EP-A3RK-01A_EBNA1BP2_chr1_43634610_-_FMO3_chr1_171072926_length(amino acids)=755AA_start in transcript=50_stop in transcript=2317
MPFPLYPHCYQLLLATPRYPLPPFVSLWVSRPRMYPEALPVGILSNPDTFKRRSGSYSNDKPEVWFAAGSGSPNQKLSSSCVGRACGEMD
TPPLSDSESESDESLVTDRELQDAFSRGLLKPGLNVVLEGPKKAVNDVNGLKQCLAEFKRDLEWVERLDVTLGPVPEIGGSEAPAPQNKD
QKAVDPEDDFQREMSFYRQAQAAVLAVLPRLHQLKVPTKRPTDYFAEMAKSDLQMQKIRQKLQTKQAAMERSEKAKQLRALRKYGKKDHA
EEGRASIYKSVFSNSSKEMMCFPDFPFPDDFPNFMHNSKIQEYIIAFAKEKNLLKYIQFKTFVSSVNKHPDFATTGQWDVTTERDGKKES
AVFDAVMVCSGHHVYPNLPKESFPGLNHFKGKCFHSRDYKEPGVFNGKRVLVVGLGNSGCDIATELSRTAEQVMISSRSGSWVMSRVWDN
GYPWDMLLVTRFGTFLKNNLPTAISDWLYVKQMNARFKHENYGLMPLNGVLRKEPVFNDELPASILCGIVSVKPNVKEFTETSAIFEDGT
IFEGIDCVIFATGYSFAYPFLDESIIKSRNNEIILFKGVFPPLLEKSTIAVIGFVQSLGAAIPTVDLQSRWAAQVIKGTCTLPSMEDMMN
DINEKMEKKRKWFGKSETIQTDYIVYMDELSSFIGAKPNIPWLFLTDPKLAMEVYFGPCSPYQFRLVGPGQWPGARNAILTQWDRSLKPM

--------------------------------------------------------------
>In-frame_ENST00000431635_ENST00000367755_TCGA-EP-A3RK-01A_EBNA1BP2_chr1_43634610_-_FMO3_chr1_171072926_length(transcript)=2695nt_BP=851nt
CCTCCCCCGGGGTCCTCCTCCGCGCCACCCCACCCCCGCGGCTCCTTTTTCTGCCTTTTCCTTTGTACCCTCACTGCTACCAGCTCCTTC
TGGCGACCCCCAGGTACCCCCTCCCACCTTTCGTTTCTCTCTGGGTCAGCAGACCACGCATGTATCCAGAGGCGCTACCTGTAGGGATCC
TAAGCAACCCGGACACTTTCAAACGCCGTAGCGGTTCCTATAGCAACGACAAACCGGAAGTATGGTTTGCCGCCGGAAGCGGAAGTCCCA
ATCAAAAGTTGAGCAGTAGCTGTGTGGGACGTGCGTGCGGCGAGATGGACACTCCCCCGCTCTCGGATTCGGAGTCGGAATCCGATGAAT
CCCTTGTCACAGACAGAGAGTTGCAGGATGCGTTTTCCCGAGGGCTTCTGAAGCCAGGCCTCAATGTCGTGCTAGAGGGGCCGAAGAAGG
CCGTGAACGACGTGAATGGCCTGAAGCAATGTTTGGCAGAATTCAAGCGGGATCTGGAATGGGTTGAAAGGCTCGATGTGACACTGGGTC
CGGTACCGGAGATCGGTGGATCTGAGGCGCCAGCACCTCAGAACAAGGACCAGAAAGCTGTTGATCCAGAAGACGACTTCCAGCGAGAGA
TGAGTTTCTATCGCCAAGCCCAGGCCGCAGTGCTTGCAGTCTTACCCCGCCTCCATCAGCTCAAAGTCCCTACGAAGCGACCCACTGATT
ATTTTGCGGAAATGGCCAAATCTGATCTGCAGATGCAGAAGATTCGACAGAAGCTGCAGACTAAACAGGCTGCCATGGAGAGGTCTGAAA
AAGCTAAGCAACTGCGAGCACTTAGGAAATACGGGAAGAAGGACCATGCAGAGGAGGGCAGGGCTAGCATTTACAAATCAGTCTTTTCCA
ACTCTTCCAAAGAGATGATGTGTTTCCCAGACTTCCCATTTCCCGATGACTTCCCCAACTTTATGCACAACAGCAAGATCCAGGAATATA
TCATTGCATTTGCCAAAGAAAAGAACCTCCTGAAGTACATACAATTTAAGACATTTGTATCCAGTGTAAATAAACATCCTGATTTTGCAA
CTACTGGCCAGTGGGATGTTACCACTGAAAGGGATGGTAAAAAAGAATCGGCTGTCTTTGATGCTGTAATGGTTTGTTCCGGACATCATG
TGTATCCCAACCTACCAAAAGAGTCCTTTCCAGGACTAAACCACTTTAAAGGCAAATGCTTCCACAGCAGGGACTATAAAGAACCAGGTG
TATTCAATGGAAAGCGTGTCCTGGTGGTTGGCCTGGGGAATTCGGGCTGTGATATTGCCACAGAACTCAGCCGCACAGCAGAACAGGTCA
TGATCAGTTCCAGAAGTGGCTCCTGGGTGATGAGCCGGGTCTGGGACAATGGTTATCCTTGGGACATGCTGCTCGTCACTCGATTTGGAA
CCTTCCTCAAGAACAATTTACCGACAGCCATCTCTGACTGGTTGTACGTGAAGCAGATGAATGCAAGATTCAAGCATGAAAACTATGGCT
TGATGCCTTTAAATGGAGTCCTGAGGAAAGAGCCTGTATTTAACGATGAGCTCCCAGCAAGCATTCTGTGTGGCATTGTGTCCGTAAAGC
CTAACGTGAAGGAATTCACAGAGACCTCGGCCATTTTTGAGGATGGGACCATATTTGAGGGCATTGACTGTGTAATCTTTGCAACAGGGT
ATAGTTTTGCCTACCCCTTCCTTGATGAGTCTATCATCAAAAGCAGAAACAATGAGATCATTTTATTTAAAGGAGTATTTCCTCCTCTAC
TTGAGAAGTCAACCATAGCAGTGATTGGCTTTGTCCAGTCCCTTGGGGCTGCCATTCCCACAGTTGACCTCCAGTCCCGCTGGGCAGCAC
AAGTAATAAAGGGAACTTGTACTTTGCCTTCTATGGAAGACATGATGAATGATATTAATGAGAAAATGGAGAAAAAGCGCAAATGGTTTG
GCAAAAGCGAGACCATACAGACAGATTACATTGTTTATATGGATGAACTCTCCTCCTTCATTGGGGCAAAGCCCAACATCCCATGGCTGT
TTCTCACAGATCCCAAATTGGCCATGGAAGTTTATTTTGGCCCTTGTAGTCCCTACCAGTTTAGGCTGGTGGGCCCAGGGCAGTGGCCAG
GAGCCAGAAATGCCATACTGACCCAGTGGGACCGGTCGTTGAAACCCATGCAGACACGAGTGGTCGGGAGACTTCAGAAGCCTTGCTTCT
TTTTCCATTGGCTGAAGCTCTTTGCAATTCCTATTCTGTTAATCGCTGTTTTCCTTGTGTTGACCTAATCATCATTTTCTCTAGGATTTC
TGAAAGTTACTGACAATACCCAGACAGGGGCTTTGCTATTTAAAAATTAAAATTTTCACACCACCTGCTTTTCTATTCAGCATCTTTTGC
AGTACTCTGTAGACATTAGTCAGTAATACAGTGTTATTTCTAGGCTCTGAAATAGCCACTTTAAGAATCATGTCATGATCTTAAGAGAGC
ACTAATCATTTCTGTTTGAGTTCCACTAACACTTCAAAATCAGAACTATGTTCTTTATATCTAACTTAAATCATTTCCTGAAACATTTTG

>In-frame_ENST00000431635_ENST00000367755_TCGA-EP-A3RK-01A_EBNA1BP2_chr1_43634610_-_FMO3_chr1_171072926_length(amino acids)=755AA_start in transcript=50_stop in transcript=2317
MPFPLYPHCYQLLLATPRYPLPPFVSLWVSRPRMYPEALPVGILSNPDTFKRRSGSYSNDKPEVWFAAGSGSPNQKLSSSCVGRACGEMD
TPPLSDSESESDESLVTDRELQDAFSRGLLKPGLNVVLEGPKKAVNDVNGLKQCLAEFKRDLEWVERLDVTLGPVPEIGGSEAPAPQNKD
QKAVDPEDDFQREMSFYRQAQAAVLAVLPRLHQLKVPTKRPTDYFAEMAKSDLQMQKIRQKLQTKQAAMERSEKAKQLRALRKYGKKDHA
EEGRASIYKSVFSNSSKEMMCFPDFPFPDDFPNFMHNSKIQEYIIAFAKEKNLLKYIQFKTFVSSVNKHPDFATTGQWDVTTERDGKKES
AVFDAVMVCSGHHVYPNLPKESFPGLNHFKGKCFHSRDYKEPGVFNGKRVLVVGLGNSGCDIATELSRTAEQVMISSRSGSWVMSRVWDN
GYPWDMLLVTRFGTFLKNNLPTAISDWLYVKQMNARFKHENYGLMPLNGVLRKEPVFNDELPASILCGIVSVKPNVKEFTETSAIFEDGT
IFEGIDCVIFATGYSFAYPFLDESIIKSRNNEIILFKGVFPPLLEKSTIAVIGFVQSLGAAIPTVDLQSRWAAQVIKGTCTLPSMEDMMN
DINEKMEKKRKWFGKSETIQTDYIVYMDELSSFIGAKPNIPWLFLTDPKLAMEVYFGPCSPYQFRLVGPGQWPGARNAILTQWDRSLKPM

--------------------------------------------------------------
>In-frame_ENST00000431635_ENST00000542847_TCGA-EP-A3RK-01A_EBNA1BP2_chr1_43634610_-_FMO3_chr1_171072926_length(transcript)=2343nt_BP=851nt
CCTCCCCCGGGGTCCTCCTCCGCGCCACCCCACCCCCGCGGCTCCTTTTTCTGCCTTTTCCTTTGTACCCTCACTGCTACCAGCTCCTTC
TGGCGACCCCCAGGTACCCCCTCCCACCTTTCGTTTCTCTCTGGGTCAGCAGACCACGCATGTATCCAGAGGCGCTACCTGTAGGGATCC
TAAGCAACCCGGACACTTTCAAACGCCGTAGCGGTTCCTATAGCAACGACAAACCGGAAGTATGGTTTGCCGCCGGAAGCGGAAGTCCCA
ATCAAAAGTTGAGCAGTAGCTGTGTGGGACGTGCGTGCGGCGAGATGGACACTCCCCCGCTCTCGGATTCGGAGTCGGAATCCGATGAAT
CCCTTGTCACAGACAGAGAGTTGCAGGATGCGTTTTCCCGAGGGCTTCTGAAGCCAGGCCTCAATGTCGTGCTAGAGGGGCCGAAGAAGG
CCGTGAACGACGTGAATGGCCTGAAGCAATGTTTGGCAGAATTCAAGCGGGATCTGGAATGGGTTGAAAGGCTCGATGTGACACTGGGTC
CGGTACCGGAGATCGGTGGATCTGAGGCGCCAGCACCTCAGAACAAGGACCAGAAAGCTGTTGATCCAGAAGACGACTTCCAGCGAGAGA
TGAGTTTCTATCGCCAAGCCCAGGCCGCAGTGCTTGCAGTCTTACCCCGCCTCCATCAGCTCAAAGTCCCTACGAAGCGACCCACTGATT
ATTTTGCGGAAATGGCCAAATCTGATCTGCAGATGCAGAAGATTCGACAGAAGCTGCAGACTAAACAGGCTGCCATGGAGAGGTCTGAAA
AAGCTAAGCAACTGCGAGCACTTAGGAAATACGGGAAGAAGGACCATGCAGAGGAGGGCAGGGCTAGCATTTACAAATCAGTCTTTTCCA
ACTCTTCCAAAGAGATGATGTGTTTCCCAGACTTCCCATTTCCCGATGACTTCCCCAACTTTATGCACAACAGCAAGATCCAGGAATATA
TCATTGCATTTGCCAAAGAAAAGAACCTCCTGAAGTACATACAATTTAAGACATTTGTATCCAGTGTAAATAAACATCCTGATTTTGCAA
CTACTGGCCAGTGGGATGTTACCACTGAAAGGGATGGTAAAAAAGAATCGGCTGTCTTTGATGCTGTAATGGTTTGTTCCGGACATCATG
TGTATCCCAACCTACCAAAAGAGTCCTTTCCAGGACTAAACCACTTTAAAGGCAAATGCTTCCACAGCAGGGACTATAAAGAACCAGGTG
TATTCAATGGAAAGCGTGTCCTGGTGGTTGGCCTGGGGAATTCGGGCTGTGATATTGCCACAGAACTCAGCCGCACAGCAGAACAGGTCA
TGATCAGTTCCAGAAGTGGCTCCTGGGTGATGAGCCGGGTCTGGGACAATGGTTATCCTTGGGACATGCTGCTCGTCACTCGATTTGGAA
CCTTCCTCAAGAACAATTTACCGACAGCCATCTCTGACTGGTTGTACGTGAAGCAGATGAATGCAAGATTCAAGCATGAAAACTATGGCT
TGATGCCTTTAAATGGAGTCCTGAGGAAAGAGCCTGTATTTAACGATGAGCTCCCAGCAAGCATTCTGTGTGGCATTGTGTCCGTAAAGC
CTAACGTGAAGGAATTCACAGAGACCTCGGCCATTTTTGAGGATGGGACCATATTTGAGGGCATTGACTGTGTAATCTTTGCAACAGGGT
ATAGTTTTGCCTACCCCTTCCTTGATGAGTCTATCATCAAAAGCAGAAACAATGAGATCATTTTATTTAAAGGAGTATTTCCTCCTCTAC
TTGAGAAGTCAACCATAGCAGTGATTGGCTTTGTCCAGTCCCTTGGGGCTGCCATTCCCACAGTTGACCTCCAGTCCCGCTGGGCAGCAC
AAGTAATAAAGGGAACTTGTACTTTGCCTTCTATGGAAGACATGATGAATGATATTAATGAGAAAATGGAGAAAAAGCGCAAATGGTTTG
GCAAAAGCGAGACCATACAGACAGATTACATTGTTTATATGGATGAACTCTCCTCCTTCATTGGGGCAAAGCCCAACATCCCATGGCTGT
TTCTCACAGATCCCAAATTGGCCATGGAAGTTTATTTTGGCCCTTGTAGTCCCTACCAGTTTAGGCTGGTGGGCCCAGGGCAGTGGCCAG
GAGCCAGAAATGCCATACTGACCCAGTGGGACCGGTCGTTGAAACCCATGCAGACACGAGTGGTCGGGAGACTTCAGAAGCCTTGCTTCT
TTTTCCATTGGCTGAAGCTCTTTGCAATTCCTATTCTGTTAATCGCTGTTTTCCTTGTGTTGACCTAATCATCATTTTCTCTAGGATTTC

>In-frame_ENST00000431635_ENST00000542847_TCGA-EP-A3RK-01A_EBNA1BP2_chr1_43634610_-_FMO3_chr1_171072926_length(amino acids)=755AA_start in transcript=50_stop in transcript=2317
MPFPLYPHCYQLLLATPRYPLPPFVSLWVSRPRMYPEALPVGILSNPDTFKRRSGSYSNDKPEVWFAAGSGSPNQKLSSSCVGRACGEMD
TPPLSDSESESDESLVTDRELQDAFSRGLLKPGLNVVLEGPKKAVNDVNGLKQCLAEFKRDLEWVERLDVTLGPVPEIGGSEAPAPQNKD
QKAVDPEDDFQREMSFYRQAQAAVLAVLPRLHQLKVPTKRPTDYFAEMAKSDLQMQKIRQKLQTKQAAMERSEKAKQLRALRKYGKKDHA
EEGRASIYKSVFSNSSKEMMCFPDFPFPDDFPNFMHNSKIQEYIIAFAKEKNLLKYIQFKTFVSSVNKHPDFATTGQWDVTTERDGKKES
AVFDAVMVCSGHHVYPNLPKESFPGLNHFKGKCFHSRDYKEPGVFNGKRVLVVGLGNSGCDIATELSRTAEQVMISSRSGSWVMSRVWDN
GYPWDMLLVTRFGTFLKNNLPTAISDWLYVKQMNARFKHENYGLMPLNGVLRKEPVFNDELPASILCGIVSVKPNVKEFTETSAIFEDGT
IFEGIDCVIFATGYSFAYPFLDESIIKSRNNEIILFKGVFPPLLEKSTIAVIGFVQSLGAAIPTVDLQSRWAAQVIKGTCTLPSMEDMMN
DINEKMEKKRKWFGKSETIQTDYIVYMDELSSFIGAKPNIPWLFLTDPKLAMEVYFGPCSPYQFRLVGPGQWPGARNAILTQWDRSLKPM

--------------------------------------------------------------
>In-frame_ENST00000236051_ENST00000392085_TCGA-EP-A3RK-01A_EBNA1BP2_chr1_43634610_-_FMO3_chr1_171072926_length(transcript)=2519nt_BP=679nt
GCGATTCGGTGGCACGTGGAGCCACGGCGTGGGAGTAGGGGGCTGAAGGCAGGCAGCAGCGGCCAGGGCCGCCCTCTGCTAGCCGCTTGG
GTCTCGGGATACCCCGTTTCTTCCTGTAGGTGTGGGACGTGCGTGCGGCGAGATGGACACTCCCCCGCTCTCGGATTCGGAGTCGGAATC
CGATGAATCCCTTGTCACAGACAGAGAGTTGCAGGATGCGTTTTCCCGAGGGCTTCTGAAGCCAGGCCTCAATGTCGTGCTAGAGGGGCC
GAAGAAGGCCGTGAACGACGTGAATGGCCTGAAGCAATGTTTGGCAGAATTCAAGCGGGATCTGGAATGGGTTGAAAGGCTCGATGTGAC
ACTGGGTCCGGTACCGGAGATCGGTGGATCTGAGGCGCCAGCACCTCAGAACAAGGACCAGAAAGCTGTTGATCCAGAAGACGACTTCCA
GCGAGAGATGAGTTTCTATCGCCAAGCCCAGGCCGCAGTGCTTGCAGTCTTACCCCGCCTCCATCAGCTCAAAGTCCCTACGAAGCGACC
CACTGATTATTTTGCGGAAATGGCCAAATCTGATCTGCAGATGCAGAAGATTCGACAGAAGCTGCAGACTAAACAGGCTGCCATGGAGAG
GTCTGAAAAAGCTAAGCAACTGCGAGCACTTAGGAAATACGGGAAGAAGGACCATGCAGAGGAGGGCAGGGCTAGCATTTACAAATCAGT
CTTTTCCAACTCTTCCAAAGAGATGATGTGTTTCCCAGACTTCCCATTTCCCGATGACTTCCCCAACTTTATGCACAACAGCAAGATCCA
GGAATATATCATTGCATTTGCCAAAGAAAAGAACCTCCTGAAGTACATACAATTTAAGACATTTGTATCCAGTGTAAATAAACATCCTGA
TTTTGCAACTACTGGCCAGTGGGATGTTACCACTGAAAGGGATGGTAAAAAAGAATCGGCTGTCTTTGATGCTGTAATGGTTTGTTCCGG
ACATCATGTGTATCCCAACCTACCAAAAGAGTCCTTTCCAGGACTAAACCACTTTAAAGGCAAATGCTTCCACAGCAGGGACTATAAAGA
ACCAGGTGTATTCAATGGAAAGCGTGTCCTGGTGGTTGGCCTGGGGAATTCGGGCTGTGATATTGCCACAGAACTCAGCCGCACAGCAGA
ACAGGTCATGATCAGTTCCAGAAGTGGCTCCTGGGTGATGAGCCGGGTCTGGGACAATGGTTATCCTTGGGACATGCTGCTCGTCACTCG
ATTTGGAACCTTCCTCAAGAACAATTTACCGACAGCCATCTCTGACTGGTTGTACGTGAAGCAGATGAATGCAAGATTCAAGCATGAAAA
CTATGGCTTGATGCCTTTAAATGGAGTCCTGAGGAAAGAGCCTGTATTTAACGATGAGCTCCCAGCAAGCATTCTGTGTGGCATTGTGTC
CGTAAAGCCTAACGTGAAGGAATTCACAGAGACCTCGGCCATTTTTGAGGATGGGACCATATTTGAGGGCATTGACTGTGTAATCTTTGC
AACAGGGTATAGTTTTGCCTACCCCTTCCTTGATGAGTCTATCATCAAAAGCAGAAACAATGAGATCATTTTATTTAAAGGAGTATTTCC
TCCTCTACTTGAGAAGTCAACCATAGCAGTGATTGGCTTTGTCCAGTCCCTTGGGGCTGCCATTCCCACAGTTGACCTCCAGTCCCGCTG
GGCAGCACAAGTAATAAAGGGAACTTGTACTTTGCCTTCTATGGAAGACATGATGAATGATATTAATGAGAAAATGGAGAAAAAGCGCAA
ATGGTTTGGCAAAAGCGAGACCATACAGACAGATTACATTGTTTATATGGATGAACTCTCCTCCTTCATTGGGGCAAAGCCCAACATCCC
ATGGCTGTTTCTCACAGATCCCAAATTGGCCATGGAAGTTTATTTTGGCCCTTGTAGTCCCTACCAGTTTAGGCTGGTGGGCCCAGGGCA
GTGGCCAGGAGCCAGAAATGCCATACTGACCCAGTGGGACCGGTCGTTGAAACCCATGCAGACACGAGTGGTCGGGAGACTTCAGAAGCC
TTGCTTCTTTTTCCATTGGCTGAAGCTCTTTGCAATTCCTATTCTGTTAATCGCTGTTTTCCTTGTGTTGACCTAATCATCATTTTCTCT
AGGATTTCTGAAAGTTACTGACAATACCCAGACAGGGGCTTTGCTATTTAAAAATTAAAATTTTCACACCACCTGCTTTTCTATTCAGCA
TCTTTTGCAGTACTCTGTAGACATTAGTCAGTAATACAGTGTTATTTCTAGGCTCTGAAATAGCCACTTTAAGAATCATGTCATGATCTT
AAGAGAGCACTAATCATTTCTGTTTGAGTTCCACTAACACTTCAAAATCAGAACTATGTTCTTTATATCTAACTTAAATCATTTCCTGAA

>In-frame_ENST00000236051_ENST00000392085_TCGA-EP-A3RK-01A_EBNA1BP2_chr1_43634610_-_FMO3_chr1_171072926_length(amino acids)=667AA_start in transcript=142_stop in transcript=2145
MDTPPLSDSESESDESLVTDRELQDAFSRGLLKPGLNVVLEGPKKAVNDVNGLKQCLAEFKRDLEWVERLDVTLGPVPEIGGSEAPAPQN
KDQKAVDPEDDFQREMSFYRQAQAAVLAVLPRLHQLKVPTKRPTDYFAEMAKSDLQMQKIRQKLQTKQAAMERSEKAKQLRALRKYGKKD
HAEEGRASIYKSVFSNSSKEMMCFPDFPFPDDFPNFMHNSKIQEYIIAFAKEKNLLKYIQFKTFVSSVNKHPDFATTGQWDVTTERDGKK
ESAVFDAVMVCSGHHVYPNLPKESFPGLNHFKGKCFHSRDYKEPGVFNGKRVLVVGLGNSGCDIATELSRTAEQVMISSRSGSWVMSRVW
DNGYPWDMLLVTRFGTFLKNNLPTAISDWLYVKQMNARFKHENYGLMPLNGVLRKEPVFNDELPASILCGIVSVKPNVKEFTETSAIFED
GTIFEGIDCVIFATGYSFAYPFLDESIIKSRNNEIILFKGVFPPLLEKSTIAVIGFVQSLGAAIPTVDLQSRWAAQVIKGTCTLPSMEDM
MNDINEKMEKKRKWFGKSETIQTDYIVYMDELSSFIGAKPNIPWLFLTDPKLAMEVYFGPCSPYQFRLVGPGQWPGARNAILTQWDRSLK

--------------------------------------------------------------
>In-frame_ENST00000236051_ENST00000367755_TCGA-EP-A3RK-01A_EBNA1BP2_chr1_43634610_-_FMO3_chr1_171072926_length(transcript)=2523nt_BP=679nt
GCGATTCGGTGGCACGTGGAGCCACGGCGTGGGAGTAGGGGGCTGAAGGCAGGCAGCAGCGGCCAGGGCCGCCCTCTGCTAGCCGCTTGG
GTCTCGGGATACCCCGTTTCTTCCTGTAGGTGTGGGACGTGCGTGCGGCGAGATGGACACTCCCCCGCTCTCGGATTCGGAGTCGGAATC
CGATGAATCCCTTGTCACAGACAGAGAGTTGCAGGATGCGTTTTCCCGAGGGCTTCTGAAGCCAGGCCTCAATGTCGTGCTAGAGGGGCC
GAAGAAGGCCGTGAACGACGTGAATGGCCTGAAGCAATGTTTGGCAGAATTCAAGCGGGATCTGGAATGGGTTGAAAGGCTCGATGTGAC
ACTGGGTCCGGTACCGGAGATCGGTGGATCTGAGGCGCCAGCACCTCAGAACAAGGACCAGAAAGCTGTTGATCCAGAAGACGACTTCCA
GCGAGAGATGAGTTTCTATCGCCAAGCCCAGGCCGCAGTGCTTGCAGTCTTACCCCGCCTCCATCAGCTCAAAGTCCCTACGAAGCGACC
CACTGATTATTTTGCGGAAATGGCCAAATCTGATCTGCAGATGCAGAAGATTCGACAGAAGCTGCAGACTAAACAGGCTGCCATGGAGAG
GTCTGAAAAAGCTAAGCAACTGCGAGCACTTAGGAAATACGGGAAGAAGGACCATGCAGAGGAGGGCAGGGCTAGCATTTACAAATCAGT
CTTTTCCAACTCTTCCAAAGAGATGATGTGTTTCCCAGACTTCCCATTTCCCGATGACTTCCCCAACTTTATGCACAACAGCAAGATCCA
GGAATATATCATTGCATTTGCCAAAGAAAAGAACCTCCTGAAGTACATACAATTTAAGACATTTGTATCCAGTGTAAATAAACATCCTGA
TTTTGCAACTACTGGCCAGTGGGATGTTACCACTGAAAGGGATGGTAAAAAAGAATCGGCTGTCTTTGATGCTGTAATGGTTTGTTCCGG
ACATCATGTGTATCCCAACCTACCAAAAGAGTCCTTTCCAGGACTAAACCACTTTAAAGGCAAATGCTTCCACAGCAGGGACTATAAAGA
ACCAGGTGTATTCAATGGAAAGCGTGTCCTGGTGGTTGGCCTGGGGAATTCGGGCTGTGATATTGCCACAGAACTCAGCCGCACAGCAGA
ACAGGTCATGATCAGTTCCAGAAGTGGCTCCTGGGTGATGAGCCGGGTCTGGGACAATGGTTATCCTTGGGACATGCTGCTCGTCACTCG
ATTTGGAACCTTCCTCAAGAACAATTTACCGACAGCCATCTCTGACTGGTTGTACGTGAAGCAGATGAATGCAAGATTCAAGCATGAAAA
CTATGGCTTGATGCCTTTAAATGGAGTCCTGAGGAAAGAGCCTGTATTTAACGATGAGCTCCCAGCAAGCATTCTGTGTGGCATTGTGTC
CGTAAAGCCTAACGTGAAGGAATTCACAGAGACCTCGGCCATTTTTGAGGATGGGACCATATTTGAGGGCATTGACTGTGTAATCTTTGC
AACAGGGTATAGTTTTGCCTACCCCTTCCTTGATGAGTCTATCATCAAAAGCAGAAACAATGAGATCATTTTATTTAAAGGAGTATTTCC
TCCTCTACTTGAGAAGTCAACCATAGCAGTGATTGGCTTTGTCCAGTCCCTTGGGGCTGCCATTCCCACAGTTGACCTCCAGTCCCGCTG
GGCAGCACAAGTAATAAAGGGAACTTGTACTTTGCCTTCTATGGAAGACATGATGAATGATATTAATGAGAAAATGGAGAAAAAGCGCAA
ATGGTTTGGCAAAAGCGAGACCATACAGACAGATTACATTGTTTATATGGATGAACTCTCCTCCTTCATTGGGGCAAAGCCCAACATCCC
ATGGCTGTTTCTCACAGATCCCAAATTGGCCATGGAAGTTTATTTTGGCCCTTGTAGTCCCTACCAGTTTAGGCTGGTGGGCCCAGGGCA
GTGGCCAGGAGCCAGAAATGCCATACTGACCCAGTGGGACCGGTCGTTGAAACCCATGCAGACACGAGTGGTCGGGAGACTTCAGAAGCC
TTGCTTCTTTTTCCATTGGCTGAAGCTCTTTGCAATTCCTATTCTGTTAATCGCTGTTTTCCTTGTGTTGACCTAATCATCATTTTCTCT
AGGATTTCTGAAAGTTACTGACAATACCCAGACAGGGGCTTTGCTATTTAAAAATTAAAATTTTCACACCACCTGCTTTTCTATTCAGCA
TCTTTTGCAGTACTCTGTAGACATTAGTCAGTAATACAGTGTTATTTCTAGGCTCTGAAATAGCCACTTTAAGAATCATGTCATGATCTT
AAGAGAGCACTAATCATTTCTGTTTGAGTTCCACTAACACTTCAAAATCAGAACTATGTTCTTTATATCTAACTTAAATCATTTCCTGAA
ACATTTTGACATGATTCCTTTTTCCTTTTAAACAATGTATGAAAGATGTATTTTAAATCTAAATAAAGAGCAAATTAAGCAGAATAATTA

>In-frame_ENST00000236051_ENST00000367755_TCGA-EP-A3RK-01A_EBNA1BP2_chr1_43634610_-_FMO3_chr1_171072926_length(amino acids)=667AA_start in transcript=142_stop in transcript=2145
MDTPPLSDSESESDESLVTDRELQDAFSRGLLKPGLNVVLEGPKKAVNDVNGLKQCLAEFKRDLEWVERLDVTLGPVPEIGGSEAPAPQN
KDQKAVDPEDDFQREMSFYRQAQAAVLAVLPRLHQLKVPTKRPTDYFAEMAKSDLQMQKIRQKLQTKQAAMERSEKAKQLRALRKYGKKD
HAEEGRASIYKSVFSNSSKEMMCFPDFPFPDDFPNFMHNSKIQEYIIAFAKEKNLLKYIQFKTFVSSVNKHPDFATTGQWDVTTERDGKK
ESAVFDAVMVCSGHHVYPNLPKESFPGLNHFKGKCFHSRDYKEPGVFNGKRVLVVGLGNSGCDIATELSRTAEQVMISSRSGSWVMSRVW
DNGYPWDMLLVTRFGTFLKNNLPTAISDWLYVKQMNARFKHENYGLMPLNGVLRKEPVFNDELPASILCGIVSVKPNVKEFTETSAIFED
GTIFEGIDCVIFATGYSFAYPFLDESIIKSRNNEIILFKGVFPPLLEKSTIAVIGFVQSLGAAIPTVDLQSRWAAQVIKGTCTLPSMEDM
MNDINEKMEKKRKWFGKSETIQTDYIVYMDELSSFIGAKPNIPWLFLTDPKLAMEVYFGPCSPYQFRLVGPGQWPGARNAILTQWDRSLK

--------------------------------------------------------------
>In-frame_ENST00000236051_ENST00000542847_TCGA-EP-A3RK-01A_EBNA1BP2_chr1_43634610_-_FMO3_chr1_171072926_length(transcript)=2171nt_BP=679nt
GCGATTCGGTGGCACGTGGAGCCACGGCGTGGGAGTAGGGGGCTGAAGGCAGGCAGCAGCGGCCAGGGCCGCCCTCTGCTAGCCGCTTGG
GTCTCGGGATACCCCGTTTCTTCCTGTAGGTGTGGGACGTGCGTGCGGCGAGATGGACACTCCCCCGCTCTCGGATTCGGAGTCGGAATC
CGATGAATCCCTTGTCACAGACAGAGAGTTGCAGGATGCGTTTTCCCGAGGGCTTCTGAAGCCAGGCCTCAATGTCGTGCTAGAGGGGCC
GAAGAAGGCCGTGAACGACGTGAATGGCCTGAAGCAATGTTTGGCAGAATTCAAGCGGGATCTGGAATGGGTTGAAAGGCTCGATGTGAC
ACTGGGTCCGGTACCGGAGATCGGTGGATCTGAGGCGCCAGCACCTCAGAACAAGGACCAGAAAGCTGTTGATCCAGAAGACGACTTCCA
GCGAGAGATGAGTTTCTATCGCCAAGCCCAGGCCGCAGTGCTTGCAGTCTTACCCCGCCTCCATCAGCTCAAAGTCCCTACGAAGCGACC
CACTGATTATTTTGCGGAAATGGCCAAATCTGATCTGCAGATGCAGAAGATTCGACAGAAGCTGCAGACTAAACAGGCTGCCATGGAGAG
GTCTGAAAAAGCTAAGCAACTGCGAGCACTTAGGAAATACGGGAAGAAGGACCATGCAGAGGAGGGCAGGGCTAGCATTTACAAATCAGT
CTTTTCCAACTCTTCCAAAGAGATGATGTGTTTCCCAGACTTCCCATTTCCCGATGACTTCCCCAACTTTATGCACAACAGCAAGATCCA
GGAATATATCATTGCATTTGCCAAAGAAAAGAACCTCCTGAAGTACATACAATTTAAGACATTTGTATCCAGTGTAAATAAACATCCTGA
TTTTGCAACTACTGGCCAGTGGGATGTTACCACTGAAAGGGATGGTAAAAAAGAATCGGCTGTCTTTGATGCTGTAATGGTTTGTTCCGG
ACATCATGTGTATCCCAACCTACCAAAAGAGTCCTTTCCAGGACTAAACCACTTTAAAGGCAAATGCTTCCACAGCAGGGACTATAAAGA
ACCAGGTGTATTCAATGGAAAGCGTGTCCTGGTGGTTGGCCTGGGGAATTCGGGCTGTGATATTGCCACAGAACTCAGCCGCACAGCAGA
ACAGGTCATGATCAGTTCCAGAAGTGGCTCCTGGGTGATGAGCCGGGTCTGGGACAATGGTTATCCTTGGGACATGCTGCTCGTCACTCG
ATTTGGAACCTTCCTCAAGAACAATTTACCGACAGCCATCTCTGACTGGTTGTACGTGAAGCAGATGAATGCAAGATTCAAGCATGAAAA
CTATGGCTTGATGCCTTTAAATGGAGTCCTGAGGAAAGAGCCTGTATTTAACGATGAGCTCCCAGCAAGCATTCTGTGTGGCATTGTGTC
CGTAAAGCCTAACGTGAAGGAATTCACAGAGACCTCGGCCATTTTTGAGGATGGGACCATATTTGAGGGCATTGACTGTGTAATCTTTGC
AACAGGGTATAGTTTTGCCTACCCCTTCCTTGATGAGTCTATCATCAAAAGCAGAAACAATGAGATCATTTTATTTAAAGGAGTATTTCC
TCCTCTACTTGAGAAGTCAACCATAGCAGTGATTGGCTTTGTCCAGTCCCTTGGGGCTGCCATTCCCACAGTTGACCTCCAGTCCCGCTG
GGCAGCACAAGTAATAAAGGGAACTTGTACTTTGCCTTCTATGGAAGACATGATGAATGATATTAATGAGAAAATGGAGAAAAAGCGCAA
ATGGTTTGGCAAAAGCGAGACCATACAGACAGATTACATTGTTTATATGGATGAACTCTCCTCCTTCATTGGGGCAAAGCCCAACATCCC
ATGGCTGTTTCTCACAGATCCCAAATTGGCCATGGAAGTTTATTTTGGCCCTTGTAGTCCCTACCAGTTTAGGCTGGTGGGCCCAGGGCA
GTGGCCAGGAGCCAGAAATGCCATACTGACCCAGTGGGACCGGTCGTTGAAACCCATGCAGACACGAGTGGTCGGGAGACTTCAGAAGCC
TTGCTTCTTTTTCCATTGGCTGAAGCTCTTTGCAATTCCTATTCTGTTAATCGCTGTTTTCCTTGTGTTGACCTAATCATCATTTTCTCT

>In-frame_ENST00000236051_ENST00000542847_TCGA-EP-A3RK-01A_EBNA1BP2_chr1_43634610_-_FMO3_chr1_171072926_length(amino acids)=667AA_start in transcript=142_stop in transcript=2145
MDTPPLSDSESESDESLVTDRELQDAFSRGLLKPGLNVVLEGPKKAVNDVNGLKQCLAEFKRDLEWVERLDVTLGPVPEIGGSEAPAPQN
KDQKAVDPEDDFQREMSFYRQAQAAVLAVLPRLHQLKVPTKRPTDYFAEMAKSDLQMQKIRQKLQTKQAAMERSEKAKQLRALRKYGKKD
HAEEGRASIYKSVFSNSSKEMMCFPDFPFPDDFPNFMHNSKIQEYIIAFAKEKNLLKYIQFKTFVSSVNKHPDFATTGQWDVTTERDGKK
ESAVFDAVMVCSGHHVYPNLPKESFPGLNHFKGKCFHSRDYKEPGVFNGKRVLVVGLGNSGCDIATELSRTAEQVMISSRSGSWVMSRVW
DNGYPWDMLLVTRFGTFLKNNLPTAISDWLYVKQMNARFKHENYGLMPLNGVLRKEPVFNDELPASILCGIVSVKPNVKEFTETSAIFED
GTIFEGIDCVIFATGYSFAYPFLDESIIKSRNNEIILFKGVFPPLLEKSTIAVIGFVQSLGAAIPTVDLQSRWAAQVIKGTCTLPSMEDM
MNDINEKMEKKRKWFGKSETIQTDYIVYMDELSSFIGAKPNIPWLFLTDPKLAMEVYFGPCSPYQFRLVGPGQWPGARNAILTQWDRSLK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for EBNA1BP2-FMO3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for EBNA1BP2-FMO3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for EBNA1BP2-FMO3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFMO3C0342739Trimethylaminuria9CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneFMO3C0019193Hepatitis, Toxic1CTD_human
TgeneFMO3C0032580Adenomatous Polyposis Coli1CTD_human
TgeneFMO3C0860207Drug-Induced Liver Disease1CTD_human
TgeneFMO3C1262760Hepatitis, Drug-Induced1CTD_human
TgeneFMO3C2713442Polyposis, Adenomatous Intestinal1CTD_human
TgeneFMO3C2713443Familial Intestinal Polyposis1CTD_human
TgeneFMO3C3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneFMO3C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneFMO3C4279912Chemically-Induced Liver Toxicity1CTD_human