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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ECE2-HTR3D (FusionGDB2 ID:24844)

Fusion Gene Summary for ECE2-HTR3D

check button Fusion gene summary
Fusion gene informationFusion gene name: ECE2-HTR3D
Fusion gene ID: 24844
HgeneTgene
Gene symbol

ECE2

HTR3D

Gene ID

110599583

200909

Gene nameEEF1AKMT4-ECE2 readthrough5-hydroxytryptamine receptor 3D
SynonymsECE-2|ECE25HT3D
Cytomap

3q27.1

3q27.1

Type of geneprotein-codingprotein-coding
DescriptionEEF1AKMT4-ECE2 readthrough transcript proteinEndothelin-converting enzyme 25-hydroxytryptamine receptor 3D5-hydroxytryptamine (serotonin) receptor 3 family member D5-hydroxytryptamine (serotonin) receptor 3D, ionotropic5-hydroxytryptamine receptor 3 subunit Dserotonin 5-HT-3D receptorserotonin receptor 3D
Modification date2020030320200313
UniProtAcc

P0DPD6

.
Ensembl transtripts involved in fusion geneENST00000324557, ENST00000402825, 
ENST00000359140, ENST00000404464, 
ENST00000357474, 		ENST00000334128, 
ENST00000428798, ENST00000382489, 
ENST00000453435, 
Fusion gene scores* DoF score4 X 3 X 1=123 X 3 X 2=18
# samples 23
** MAII scorelog2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ECE2 [Title/Abstract] AND HTR3D [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointECE2(183967678)-HTR3D(183756196), # samples:1
Anticipated loss of major functional domain due to fusion event.ECE2-HTR3D seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ECE2-HTR3D seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ECE2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across HTR3D (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-56-5898ECE2chr3

183967678

+HTR3Dchr3

183756196

+


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Fusion Gene ORF analysis for ECE2-HTR3D

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000324557ENST00000334128ECE2chr3

183967678

+HTR3Dchr3

183756196

+
In-frameENST00000324557ENST00000428798ECE2chr3

183967678

+HTR3Dchr3

183756196

+
Frame-shiftENST00000324557ENST00000382489ECE2chr3

183967678

+HTR3Dchr3

183756196

+
In-frameENST00000324557ENST00000453435ECE2chr3

183967678

+HTR3Dchr3

183756196

+
In-frameENST00000402825ENST00000334128ECE2chr3

183967678

+HTR3Dchr3

183756196

+
In-frameENST00000402825ENST00000428798ECE2chr3

183967678

+HTR3Dchr3

183756196

+
Frame-shiftENST00000402825ENST00000382489ECE2chr3

183967678

+HTR3Dchr3

183756196

+
In-frameENST00000402825ENST00000453435ECE2chr3

183967678

+HTR3Dchr3

183756196

+
intron-3CDSENST00000359140ENST00000334128ECE2chr3

183967678

+HTR3Dchr3

183756196

+
intron-3CDSENST00000359140ENST00000428798ECE2chr3

183967678

+HTR3Dchr3

183756196

+
intron-3CDSENST00000359140ENST00000382489ECE2chr3

183967678

+HTR3Dchr3

183756196

+
intron-3CDSENST00000359140ENST00000453435ECE2chr3

183967678

+HTR3Dchr3

183756196

+
intron-3CDSENST00000404464ENST00000334128ECE2chr3

183967678

+HTR3Dchr3

183756196

+
intron-3CDSENST00000404464ENST00000428798ECE2chr3

183967678

+HTR3Dchr3

183756196

+
intron-3CDSENST00000404464ENST00000382489ECE2chr3

183967678

+HTR3Dchr3

183756196

+
intron-3CDSENST00000404464ENST00000453435ECE2chr3

183967678

+HTR3Dchr3

183756196

+
intron-3CDSENST00000357474ENST00000334128ECE2chr3

183967678

+HTR3Dchr3

183756196

+
intron-3CDSENST00000357474ENST00000428798ECE2chr3

183967678

+HTR3Dchr3

183756196

+
intron-3CDSENST00000357474ENST00000382489ECE2chr3

183967678

+HTR3Dchr3

183756196

+
intron-3CDSENST00000357474ENST00000453435ECE2chr3

183967678

+HTR3Dchr3

183756196

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000324557ECE2chr3183967678+ENST00000334128HTR3Dchr3183756196+108124145686213
ENST00000324557ECE2chr3183967678+ENST00000428798HTR3Dchr3183756196+68724145686213
ENST00000324557ECE2chr3183967678+ENST00000453435HTR3Dchr3183756196+91224145686213
ENST00000402825ECE2chr3183967678+ENST00000334128HTR3Dchr3183756196+10361960641213
ENST00000402825ECE2chr3183967678+ENST00000428798HTR3Dchr3183756196+6421960641213
ENST00000402825ECE2chr3183967678+ENST00000453435HTR3Dchr3183756196+8671960641213

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000324557ENST00000334128ECE2chr3183967678+HTR3Dchr3183756196+0.130063850.8699361
ENST00000324557ENST00000428798ECE2chr3183967678+HTR3Dchr3183756196+0.094036030.9059639
ENST00000324557ENST00000453435ECE2chr3183967678+HTR3Dchr3183756196+0.079986730.92001325
ENST00000402825ENST00000334128ECE2chr3183967678+HTR3Dchr3183756196+0.157798980.842201
ENST00000402825ENST00000428798ECE2chr3183967678+HTR3Dchr3183756196+0.125825720.8741743
ENST00000402825ENST00000453435ECE2chr3183967678+HTR3Dchr3183756196+0.1004140450.899586

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Fusion Genomic Features for ECE2-HTR3D


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ECE2chr3183967678+HTR3Dchr3183756196+9.82E-080.9999999
ECE2chr3183967678+HTR3Dchr3183756196+9.82E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ECE2-HTR3D


check button Go to

FGviewer for the breakpoints of chr3:183967678-chr3:183756196

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ECE2

P0DPD6

.
FUNCTION: Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May play a role in amyloid-beta processing (By similarity). {ECO:0000250|UniProtKB:B2RQR8, ECO:0000269|PubMed:12560336}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHTR3Dchr3:183967678chr3:183756196ENST0000038248908254_2640.0455.0Topological domainCytoplasmic
TgeneHTR3Dchr3:183967678chr3:183756196ENST000003824890825_2320.0455.0Topological domainExtracellular
TgeneHTR3Dchr3:183967678chr3:183756196ENST0000038248908286_3060.0455.0Topological domainExtracellular
TgeneHTR3Dchr3:183967678chr3:183756196ENST0000038248908328_4310.0455.0Topological domainCytoplasmic
TgeneHTR3Dchr3:183967678chr3:183756196ENST0000038248908453_4540.0455.0Topological domainExtracellular
TgeneHTR3Dchr3:183967678chr3:183756196ENST0000042879858254_264256.3333333333333405.0Topological domainCytoplasmic
TgeneHTR3Dchr3:183967678chr3:183756196ENST0000042879858286_306256.3333333333333405.0Topological domainExtracellular
TgeneHTR3Dchr3:183967678chr3:183756196ENST0000042879858328_431256.3333333333333405.0Topological domainCytoplasmic
TgeneHTR3Dchr3:183967678chr3:183756196ENST0000042879858453_454256.3333333333333405.0Topological domainExtracellular
TgeneHTR3Dchr3:183967678chr3:183756196ENST0000045343514254_26485.33333333333333234.0Topological domainCytoplasmic
TgeneHTR3Dchr3:183967678chr3:183756196ENST0000045343514286_30685.33333333333333234.0Topological domainExtracellular
TgeneHTR3Dchr3:183967678chr3:183756196ENST0000045343514328_43185.33333333333333234.0Topological domainCytoplasmic
TgeneHTR3Dchr3:183967678chr3:183756196ENST0000045343514453_45485.33333333333333234.0Topological domainExtracellular
TgeneHTR3Dchr3:183967678chr3:183756196ENST0000038248908233_2530.0455.0TransmembraneHelical%3B Name%3D1
TgeneHTR3Dchr3:183967678chr3:183756196ENST0000038248908265_2850.0455.0TransmembraneHelical%3B Name%3D2
TgeneHTR3Dchr3:183967678chr3:183756196ENST0000038248908307_3270.0455.0TransmembraneHelical%3B Name%3D3
TgeneHTR3Dchr3:183967678chr3:183756196ENST0000038248908432_4520.0455.0TransmembraneHelical%3B Name%3D4
TgeneHTR3Dchr3:183967678chr3:183756196ENST0000042879858265_285256.3333333333333405.0TransmembraneHelical%3B Name%3D2
TgeneHTR3Dchr3:183967678chr3:183756196ENST0000042879858307_327256.3333333333333405.0TransmembraneHelical%3B Name%3D3
TgeneHTR3Dchr3:183967678chr3:183756196ENST0000042879858432_452256.3333333333333405.0TransmembraneHelical%3B Name%3D4
TgeneHTR3Dchr3:183967678chr3:183756196ENST0000045343514233_25385.33333333333333234.0TransmembraneHelical%3B Name%3D1
TgeneHTR3Dchr3:183967678chr3:183756196ENST0000045343514265_28585.33333333333333234.0TransmembraneHelical%3B Name%3D2
TgeneHTR3Dchr3:183967678chr3:183756196ENST0000045343514307_32785.33333333333333234.0TransmembraneHelical%3B Name%3D3
TgeneHTR3Dchr3:183967678chr3:183756196ENST0000045343514432_45285.33333333333333234.0TransmembraneHelical%3B Name%3D4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHTR3Dchr3:183967678chr3:183756196ENST000004287985825_232256.3333333333333405.0Topological domainExtracellular
TgeneHTR3Dchr3:183967678chr3:183756196ENST000004534351425_23285.33333333333333234.0Topological domainExtracellular
TgeneHTR3Dchr3:183967678chr3:183756196ENST0000042879858233_253256.3333333333333405.0TransmembraneHelical%3B Name%3D1


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Fusion Gene Sequence for ECE2-HTR3D


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000324557_ENST00000334128_TCGA-56-5898_ECE2_chr3_183967678_+_HTR3D_chr3_183756196_length(transcript)=1081nt_BP=241nt
ATTGGCTGAAGGGCCGGCGGCTCTGGCTGCCCGGCGGTTGAGAGCATGGCCTCTCCAGGGGCAGGTAGGGCGCCTCCGGAGTTACCGGAG
CGGAACTGCGGGTACCGCGAAGTCGAGTACTGGGATCAGCGCTACCAAGGCGCAGCCGATTCTGCCCCCTACGATTGGTTCGGGGACTTC
TCCTCCTTCCGTGCCCTCCTAGAGCCGGAGCTGCGGCCCGAGGACCGTATCCTTGTGCTAGGTGTCTACTTCGCCCTGTGCCTGTCCCTG
ATGGTGGGCAGCCTGCTGGAGACCATCTTCATCACCCACCTGCTGCACGTGGCCACCACCCAGCCCCTACCTCTGCCTCGGTGGCTCCAC
TCCCTGCTGCTGCACTGCACCGGCCAAGGGAGATGCTGTCCCACTGCGCCCCAGAAGGGAAATAAGGGCCCGGGTCTCACCCCCACCCAC
CTGCCCGGTGTGAAGGAGCCAGAGGTATCAGCAGGGCAGATGCCAGGCCCTGGGGAGGCAGAGCTGACAGGGGGCTCAGAATGGACAAGG
GCCCAGCGGGAACACGAGGCCCAGAAGCAGCACTCGGTGGAGCTGTGGGTGCAGTTCAGCCACGCGATGGACGCCCTGCTCTTCCGCCTC
TACCTGCTCTTCATGGCCTCCTCCATCATCACCGTCATATGCCTCTGGAACACCTAGGCAGGTGCTCACCTGCAAACTTCAGTCTGGACT
TCTTTTTGCCAGAGAACTCCAGAAACCAGTCAGGCTCTCAGTCAGCCTTGTGGCCCTGTCAACCGCCTCATTTTTAACCCAGTCCTCTGT
GTAGTTTCAGACCAGACCTGAATAGTCTCCTATGCCCTCCAAAAGTCGGGTCCTTGCTCCTGCATGCCATCAGCCCCACTCAGCCCTCCC
ATACCTCCCTGGCTCCTCAGGATTCAGGTTCCTAGGGTACGTCCTTGATTAAATCACCCCAATATGCCCCTTTGCAGAAAGTATTGGCTT
TTCCCTGAATTCTGTTATGGTAAAAAAAATCTTGGGATTGAGAGTCTTCTTGCAGAAACTTCTCAGCCAAAGTAAAAAGGATTTTCTCTT

>In-frame_ENST00000324557_ENST00000334128_TCGA-56-5898_ECE2_chr3_183967678_+_HTR3D_chr3_183756196_length(amino acids)=213AA_start in transcript=45_stop in transcript=686
MASPGAGRAPPELPERNCGYREVEYWDQRYQGAADSAPYDWFGDFSSFRALLEPELRPEDRILVLGVYFALCLSLMVGSLLETIFITHLL
HVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVEL

--------------------------------------------------------------
>In-frame_ENST00000324557_ENST00000428798_TCGA-56-5898_ECE2_chr3_183967678_+_HTR3D_chr3_183756196_length(transcript)=687nt_BP=241nt
ATTGGCTGAAGGGCCGGCGGCTCTGGCTGCCCGGCGGTTGAGAGCATGGCCTCTCCAGGGGCAGGTAGGGCGCCTCCGGAGTTACCGGAG
CGGAACTGCGGGTACCGCGAAGTCGAGTACTGGGATCAGCGCTACCAAGGCGCAGCCGATTCTGCCCCCTACGATTGGTTCGGGGACTTC
TCCTCCTTCCGTGCCCTCCTAGAGCCGGAGCTGCGGCCCGAGGACCGTATCCTTGTGCTAGGTGTCTACTTCGCCCTGTGCCTGTCCCTG
ATGGTGGGCAGCCTGCTGGAGACCATCTTCATCACCCACCTGCTGCACGTGGCCACCACCCAGCCCCTACCTCTGCCTCGGTGGCTCCAC
TCCCTGCTGCTGCACTGCACCGGCCAAGGGAGATGCTGTCCCACTGCGCCCCAGAAGGGAAATAAGGGCCCGGGTCTCACCCCCACCCAC
CTGCCCGGTGTGAAGGAGCCAGAGGTATCAGCAGGGCAGATGCCAGGCCCTGGGGAGGCAGAGCTGACAGGGGGCTCAGAATGGACAAGG
GCCCAGCGGGAACACGAGGCCCAGAAGCAGCACTCGGTGGAGCTGTGGGTGCAGTTCAGCCACGCGATGGACGCCCTGCTCTTCCGCCTC

>In-frame_ENST00000324557_ENST00000428798_TCGA-56-5898_ECE2_chr3_183967678_+_HTR3D_chr3_183756196_length(amino acids)=213AA_start in transcript=45_stop in transcript=686
MASPGAGRAPPELPERNCGYREVEYWDQRYQGAADSAPYDWFGDFSSFRALLEPELRPEDRILVLGVYFALCLSLMVGSLLETIFITHLL
HVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVEL

--------------------------------------------------------------
>In-frame_ENST00000324557_ENST00000453435_TCGA-56-5898_ECE2_chr3_183967678_+_HTR3D_chr3_183756196_length(transcript)=912nt_BP=241nt
ATTGGCTGAAGGGCCGGCGGCTCTGGCTGCCCGGCGGTTGAGAGCATGGCCTCTCCAGGGGCAGGTAGGGCGCCTCCGGAGTTACCGGAG
CGGAACTGCGGGTACCGCGAAGTCGAGTACTGGGATCAGCGCTACCAAGGCGCAGCCGATTCTGCCCCCTACGATTGGTTCGGGGACTTC
TCCTCCTTCCGTGCCCTCCTAGAGCCGGAGCTGCGGCCCGAGGACCGTATCCTTGTGCTAGGTGTCTACTTCGCCCTGTGCCTGTCCCTG
ATGGTGGGCAGCCTGCTGGAGACCATCTTCATCACCCACCTGCTGCACGTGGCCACCACCCAGCCCCTACCTCTGCCTCGGTGGCTCCAC
TCCCTGCTGCTGCACTGCACCGGCCAAGGGAGATGCTGTCCCACTGCGCCCCAGAAGGGAAATAAGGGCCCGGGTCTCACCCCCACCCAC
CTGCCCGGTGTGAAGGAGCCAGAGGTATCAGCAGGGCAGATGCCAGGCCCTGGGGAGGCAGAGCTGACAGGGGGCTCAGAATGGACAAGG
GCCCAGCGGGAACACGAGGCCCAGAAGCAGCACTCGGTGGAGCTGTGGGTGCAGTTCAGCCACGCGATGGACGCCCTGCTCTTCCGCCTC
TACCTGCTCTTCATGGCCTCCTCCATCATCACCGTCATATGCCTCTGGAACACCTAGGCAGGTGCTCACCTGCAAACTTCAGTCTGGACT
TCTTTTTGCCAGAGAACTCCAGAAACCAGTCAGGCTCTCAGTCAGCCTTGTGGCCCTGTCAACCGCCTCATTTTTAACCCAGTCCTCTGT
GTAGTTTCAGACCAGACCTGAATAGTCTCCTATGCCCTCCAAAAGTCGGGTCCTTGCTCCTGCATGCCATCAGCCCCACTCAGCCCTCCC

>In-frame_ENST00000324557_ENST00000453435_TCGA-56-5898_ECE2_chr3_183967678_+_HTR3D_chr3_183756196_length(amino acids)=213AA_start in transcript=45_stop in transcript=686
MASPGAGRAPPELPERNCGYREVEYWDQRYQGAADSAPYDWFGDFSSFRALLEPELRPEDRILVLGVYFALCLSLMVGSLLETIFITHLL
HVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVEL

--------------------------------------------------------------
>In-frame_ENST00000402825_ENST00000334128_TCGA-56-5898_ECE2_chr3_183967678_+_HTR3D_chr3_183756196_length(transcript)=1036nt_BP=196nt
ATGGCCTCTCCAGGGGCAGGTAGGGCGCCTCCGGAGTTACCGGAGCGGAACTGCGGGTACCGCGAAGTCGAGTACTGGGATCAGCGCTAC
CAAGGCGCAGCCGATTCTGCCCCCTACGATTGGTTCGGGGACTTCTCCTCCTTCCGTGCCCTCCTAGAGCCGGAGCTGCGGCCCGAGGAC
CGTATCCTTGTGCTAGGTGTCTACTTCGCCCTGTGCCTGTCCCTGATGGTGGGCAGCCTGCTGGAGACCATCTTCATCACCCACCTGCTG
CACGTGGCCACCACCCAGCCCCTACCTCTGCCTCGGTGGCTCCACTCCCTGCTGCTGCACTGCACCGGCCAAGGGAGATGCTGTCCCACT
GCGCCCCAGAAGGGAAATAAGGGCCCGGGTCTCACCCCCACCCACCTGCCCGGTGTGAAGGAGCCAGAGGTATCAGCAGGGCAGATGCCA
GGCCCTGGGGAGGCAGAGCTGACAGGGGGCTCAGAATGGACAAGGGCCCAGCGGGAACACGAGGCCCAGAAGCAGCACTCGGTGGAGCTG
TGGGTGCAGTTCAGCCACGCGATGGACGCCCTGCTCTTCCGCCTCTACCTGCTCTTCATGGCCTCCTCCATCATCACCGTCATATGCCTC
TGGAACACCTAGGCAGGTGCTCACCTGCAAACTTCAGTCTGGACTTCTTTTTGCCAGAGAACTCCAGAAACCAGTCAGGCTCTCAGTCAG
CCTTGTGGCCCTGTCAACCGCCTCATTTTTAACCCAGTCCTCTGTGTAGTTTCAGACCAGACCTGAATAGTCTCCTATGCCCTCCAAAAG
TCGGGTCCTTGCTCCTGCATGCCATCAGCCCCACTCAGCCCTCCCATACCTCCCTGGCTCCTCAGGATTCAGGTTCCTAGGGTACGTCCT
TGATTAAATCACCCCAATATGCCCCTTTGCAGAAAGTATTGGCTTTTCCCTGAATTCTGTTATGGTAAAAAAAATCTTGGGATTGAGAGT

>In-frame_ENST00000402825_ENST00000334128_TCGA-56-5898_ECE2_chr3_183967678_+_HTR3D_chr3_183756196_length(amino acids)=213AA_start in transcript=0_stop in transcript=641
MASPGAGRAPPELPERNCGYREVEYWDQRYQGAADSAPYDWFGDFSSFRALLEPELRPEDRILVLGVYFALCLSLMVGSLLETIFITHLL
HVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVEL

--------------------------------------------------------------
>In-frame_ENST00000402825_ENST00000428798_TCGA-56-5898_ECE2_chr3_183967678_+_HTR3D_chr3_183756196_length(transcript)=642nt_BP=196nt
ATGGCCTCTCCAGGGGCAGGTAGGGCGCCTCCGGAGTTACCGGAGCGGAACTGCGGGTACCGCGAAGTCGAGTACTGGGATCAGCGCTAC
CAAGGCGCAGCCGATTCTGCCCCCTACGATTGGTTCGGGGACTTCTCCTCCTTCCGTGCCCTCCTAGAGCCGGAGCTGCGGCCCGAGGAC
CGTATCCTTGTGCTAGGTGTCTACTTCGCCCTGTGCCTGTCCCTGATGGTGGGCAGCCTGCTGGAGACCATCTTCATCACCCACCTGCTG
CACGTGGCCACCACCCAGCCCCTACCTCTGCCTCGGTGGCTCCACTCCCTGCTGCTGCACTGCACCGGCCAAGGGAGATGCTGTCCCACT
GCGCCCCAGAAGGGAAATAAGGGCCCGGGTCTCACCCCCACCCACCTGCCCGGTGTGAAGGAGCCAGAGGTATCAGCAGGGCAGATGCCA
GGCCCTGGGGAGGCAGAGCTGACAGGGGGCTCAGAATGGACAAGGGCCCAGCGGGAACACGAGGCCCAGAAGCAGCACTCGGTGGAGCTG
TGGGTGCAGTTCAGCCACGCGATGGACGCCCTGCTCTTCCGCCTCTACCTGCTCTTCATGGCCTCCTCCATCATCACCGTCATATGCCTC

>In-frame_ENST00000402825_ENST00000428798_TCGA-56-5898_ECE2_chr3_183967678_+_HTR3D_chr3_183756196_length(amino acids)=213AA_start in transcript=0_stop in transcript=641
MASPGAGRAPPELPERNCGYREVEYWDQRYQGAADSAPYDWFGDFSSFRALLEPELRPEDRILVLGVYFALCLSLMVGSLLETIFITHLL
HVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVEL

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>In-frame_ENST00000402825_ENST00000453435_TCGA-56-5898_ECE2_chr3_183967678_+_HTR3D_chr3_183756196_length(transcript)=867nt_BP=196nt
ATGGCCTCTCCAGGGGCAGGTAGGGCGCCTCCGGAGTTACCGGAGCGGAACTGCGGGTACCGCGAAGTCGAGTACTGGGATCAGCGCTAC
CAAGGCGCAGCCGATTCTGCCCCCTACGATTGGTTCGGGGACTTCTCCTCCTTCCGTGCCCTCCTAGAGCCGGAGCTGCGGCCCGAGGAC
CGTATCCTTGTGCTAGGTGTCTACTTCGCCCTGTGCCTGTCCCTGATGGTGGGCAGCCTGCTGGAGACCATCTTCATCACCCACCTGCTG
CACGTGGCCACCACCCAGCCCCTACCTCTGCCTCGGTGGCTCCACTCCCTGCTGCTGCACTGCACCGGCCAAGGGAGATGCTGTCCCACT
GCGCCCCAGAAGGGAAATAAGGGCCCGGGTCTCACCCCCACCCACCTGCCCGGTGTGAAGGAGCCAGAGGTATCAGCAGGGCAGATGCCA
GGCCCTGGGGAGGCAGAGCTGACAGGGGGCTCAGAATGGACAAGGGCCCAGCGGGAACACGAGGCCCAGAAGCAGCACTCGGTGGAGCTG
TGGGTGCAGTTCAGCCACGCGATGGACGCCCTGCTCTTCCGCCTCTACCTGCTCTTCATGGCCTCCTCCATCATCACCGTCATATGCCTC
TGGAACACCTAGGCAGGTGCTCACCTGCAAACTTCAGTCTGGACTTCTTTTTGCCAGAGAACTCCAGAAACCAGTCAGGCTCTCAGTCAG
CCTTGTGGCCCTGTCAACCGCCTCATTTTTAACCCAGTCCTCTGTGTAGTTTCAGACCAGACCTGAATAGTCTCCTATGCCCTCCAAAAG

>In-frame_ENST00000402825_ENST00000453435_TCGA-56-5898_ECE2_chr3_183967678_+_HTR3D_chr3_183756196_length(amino acids)=213AA_start in transcript=0_stop in transcript=641
MASPGAGRAPPELPERNCGYREVEYWDQRYQGAADSAPYDWFGDFSSFRALLEPELRPEDRILVLGVYFALCLSLMVGSLLETIFITHLL
HVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVEL

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Fusion Gene PPI Analysis for ECE2-HTR3D


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ECE2-HTR3D


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ECE2-HTR3D


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHTR3DC0036341Schizophrenia1PSYGENET