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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:EEF1D-PUF60 (FusionGDB2 ID:25154)

Fusion Gene Summary for EEF1D-PUF60

Fusion gene summary

Fusion gene information	Fusion gene name: EEF1D-PUF60
	Fusion gene ID: 25154
		Hgene	Tgene
	Gene symbol	EEF1D	PUF60
	Gene ID	1936	22827
	Gene name	eukaryotic translation elongation factor 1 delta	poly(U) binding splicing factor 60
	Synonyms	EF-1D\|EF1D\|FP1047	FIR\|RoBPI\|SIAHBP1\|VRJS
	Cytomap	8q24.3	8q24.3
	Type of gene	protein-coding	protein-coding
	Description	elongation factor 1-deltaEF-1-deltaantigen NY-CO-4eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)	poly(U)-binding-splicing factor PUF60FBP interacting repressorFUSE-binding protein-interacting repressorRo ribonucleoprotein-binding protein 1Siah binding protein 1poly(U) binding splicing factor 60KDapyrimidine tract binding splicing factor
	Modification date	20200313	20200313
	UniProtAcc	P29692	.
	Ensembl transtripts involved in fusion gene	ENST00000419152, ENST00000532400, ENST00000532741, ENST00000317198, ENST00000526838, ENST00000442189, ENST00000528610, ENST00000423316, ENST00000395119, ENST00000529272, ENST00000531621, ENST00000524624, ENST00000531770,	ENST00000526683, ENST00000453551, ENST00000313352, ENST00000456095, ENST00000349157, ENST00000527197, ENST00000524570,
Fusion gene scores	* DoF score	16 X 12 X 5=960	5 X 8 X 4=160
	# samples	20	7
	** MAII score	log2(20/960*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/160*10)=-1.1926450779424 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: EEF1D [Title/Abstract] AND PUF60 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	EEF1D(144679518)-PUF60(144904083), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	EEF1D	GO:0071479	cellular response to ionizing radiation	8168075

Fusion gene breakpoints across EEF1D (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PUF60 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-25-2392-01A	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
ChimerDB4	OV	TCGA-25-2392	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
ChimerDB4	OV	TCGA-25-2392-01A	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-

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Fusion Gene ORF analysis for EEF1D-PUF60

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000419152	ENST00000526683	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000419152	ENST00000453551	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000419152	ENST00000313352	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000419152	ENST00000456095	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000419152	ENST00000349157	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000419152	ENST00000527197	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000419152	ENST00000524570	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-3CDS	ENST00000532400	ENST00000526683	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000532400	ENST00000453551	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000532400	ENST00000313352	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000532400	ENST00000456095	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000532400	ENST00000349157	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000532400	ENST00000527197	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000532400	ENST00000524570	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
intron-3CDS	ENST00000532741	ENST00000526683	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
intron-5UTR	ENST00000532741	ENST00000453551	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
intron-5UTR	ENST00000532741	ENST00000313352	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
intron-5UTR	ENST00000532741	ENST00000456095	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
intron-5UTR	ENST00000532741	ENST00000349157	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
intron-5UTR	ENST00000532741	ENST00000527197	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
intron-5UTR	ENST00000532741	ENST00000524570	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
intron-3CDS	ENST00000317198	ENST00000526683	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
intron-5UTR	ENST00000317198	ENST00000453551	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
intron-5UTR	ENST00000317198	ENST00000313352	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
intron-5UTR	ENST00000317198	ENST00000456095	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
intron-5UTR	ENST00000317198	ENST00000349157	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
intron-5UTR	ENST00000317198	ENST00000527197	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
intron-5UTR	ENST00000317198	ENST00000524570	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-3CDS	ENST00000526838	ENST00000526683	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000526838	ENST00000453551	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000526838	ENST00000313352	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000526838	ENST00000456095	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000526838	ENST00000349157	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000526838	ENST00000527197	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000526838	ENST00000524570	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-3CDS	ENST00000442189	ENST00000526683	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000442189	ENST00000453551	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000442189	ENST00000313352	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000442189	ENST00000456095	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000442189	ENST00000349157	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000442189	ENST00000527197	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000442189	ENST00000524570	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-3CDS	ENST00000528610	ENST00000526683	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000528610	ENST00000453551	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000528610	ENST00000313352	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000528610	ENST00000456095	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000528610	ENST00000349157	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000528610	ENST00000527197	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000528610	ENST00000524570	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-3CDS	ENST00000423316	ENST00000526683	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000423316	ENST00000453551	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000423316	ENST00000313352	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000423316	ENST00000456095	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000423316	ENST00000349157	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000423316	ENST00000527197	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000423316	ENST00000524570	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-3CDS	ENST00000395119	ENST00000526683	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000395119	ENST00000453551	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000395119	ENST00000313352	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000395119	ENST00000456095	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000395119	ENST00000349157	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000395119	ENST00000527197	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000395119	ENST00000524570	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-3CDS	ENST00000529272	ENST00000526683	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000529272	ENST00000453551	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000529272	ENST00000313352	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000529272	ENST00000456095	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000529272	ENST00000349157	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000529272	ENST00000527197	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000529272	ENST00000524570	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-3CDS	ENST00000531621	ENST00000526683	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000531621	ENST00000453551	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000531621	ENST00000313352	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000531621	ENST00000456095	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000531621	ENST00000349157	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000531621	ENST00000527197	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000531621	ENST00000524570	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-3CDS	ENST00000524624	ENST00000526683	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000524624	ENST00000453551	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000524624	ENST00000313352	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000524624	ENST00000456095	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000524624	ENST00000349157	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000524624	ENST00000527197	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000524624	ENST00000524570	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-3CDS	ENST00000531770	ENST00000526683	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000531770	ENST00000453551	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000531770	ENST00000313352	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000531770	ENST00000456095	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000531770	ENST00000349157	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000531770	ENST00000527197	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000531770	ENST00000524570	EEF1D	chr8	144679518	-	PUF60	chr8	144904083	-
5UTR-3CDS	ENST00000419152	ENST00000526683	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000419152	ENST00000453551	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000419152	ENST00000313352	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000419152	ENST00000456095	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000419152	ENST00000349157	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000419152	ENST00000527197	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000419152	ENST00000524570	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-3CDS	ENST00000532400	ENST00000526683	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000532400	ENST00000453551	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000532400	ENST00000313352	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000532400	ENST00000456095	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000532400	ENST00000349157	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000532400	ENST00000527197	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000532400	ENST00000524570	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
intron-3CDS	ENST00000532741	ENST00000526683	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
intron-5UTR	ENST00000532741	ENST00000453551	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
intron-5UTR	ENST00000532741	ENST00000313352	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
intron-5UTR	ENST00000532741	ENST00000456095	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
intron-5UTR	ENST00000532741	ENST00000349157	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
intron-5UTR	ENST00000532741	ENST00000527197	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
intron-5UTR	ENST00000532741	ENST00000524570	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
intron-3CDS	ENST00000317198	ENST00000526683	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
intron-5UTR	ENST00000317198	ENST00000453551	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
intron-5UTR	ENST00000317198	ENST00000313352	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
intron-5UTR	ENST00000317198	ENST00000456095	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
intron-5UTR	ENST00000317198	ENST00000349157	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
intron-5UTR	ENST00000317198	ENST00000527197	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
intron-5UTR	ENST00000317198	ENST00000524570	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-3CDS	ENST00000526838	ENST00000526683	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000526838	ENST00000453551	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000526838	ENST00000313352	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000526838	ENST00000456095	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000526838	ENST00000349157	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000526838	ENST00000527197	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000526838	ENST00000524570	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-3CDS	ENST00000442189	ENST00000526683	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000442189	ENST00000453551	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000442189	ENST00000313352	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000442189	ENST00000456095	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000442189	ENST00000349157	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000442189	ENST00000527197	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000442189	ENST00000524570	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-3CDS	ENST00000528610	ENST00000526683	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000528610	ENST00000453551	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000528610	ENST00000313352	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000528610	ENST00000456095	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000528610	ENST00000349157	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000528610	ENST00000527197	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000528610	ENST00000524570	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-3CDS	ENST00000423316	ENST00000526683	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000423316	ENST00000453551	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000423316	ENST00000313352	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000423316	ENST00000456095	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000423316	ENST00000349157	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000423316	ENST00000527197	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000423316	ENST00000524570	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-3CDS	ENST00000395119	ENST00000526683	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000395119	ENST00000453551	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000395119	ENST00000313352	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000395119	ENST00000456095	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000395119	ENST00000349157	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000395119	ENST00000527197	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000395119	ENST00000524570	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-3CDS	ENST00000529272	ENST00000526683	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000529272	ENST00000453551	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000529272	ENST00000313352	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000529272	ENST00000456095	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000529272	ENST00000349157	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000529272	ENST00000527197	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000529272	ENST00000524570	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-3CDS	ENST00000531621	ENST00000526683	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000531621	ENST00000453551	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000531621	ENST00000313352	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000531621	ENST00000456095	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000531621	ENST00000349157	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000531621	ENST00000527197	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000531621	ENST00000524570	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-3CDS	ENST00000524624	ENST00000526683	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000524624	ENST00000453551	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000524624	ENST00000313352	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000524624	ENST00000456095	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000524624	ENST00000349157	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000524624	ENST00000527197	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000524624	ENST00000524570	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-3CDS	ENST00000531770	ENST00000526683	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000531770	ENST00000453551	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000531770	ENST00000313352	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000531770	ENST00000456095	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000531770	ENST00000349157	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000531770	ENST00000527197	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-
5UTR-5UTR	ENST00000531770	ENST00000524570	EEF1D	chr8	144679517	-	PUF60	chr8	144904083	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for EEF1D-PUF60

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EEF1D-PUF60

Go to
FGviewer for the breakpoints of :-:
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EEF1D P29692	.
FUNCTION: [Isoform 1]: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.; FUNCTION: [Isoform 2]: Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE).	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for EEF1D-PUF60

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for EEF1D-PUF60

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for EEF1D-PUF60

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for EEF1D-PUF60

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	PUF60	C3810023	VERHEIJ SYNDROME	2	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	PUF60	C0025500	Mesothelioma	1	CTD_human
Tgene	PUF60	C0027540	Necrosis	1	CTD_human
Tgene	PUF60	C0027659	Neoplasms, Experimental	1	CTD_human
Tgene	PUF60	C3714756	Intellectual Disability	1	GENOMICS_ENGLAND