FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:EEF2-EEF2 (FusionGDB2 ID:25200)

Fusion Gene Summary for EEF2-EEF2

check button Fusion gene summary
Fusion gene informationFusion gene name: EEF2-EEF2
Fusion gene ID: 25200
HgeneTgene
Gene symbol

EEF2

EEF2

Gene ID

1938

1938

Gene nameeukaryotic translation elongation factor 2eukaryotic translation elongation factor 2
SynonymsEEF-2|EF-2|EF2|SCA26EEF-2|EF-2|EF2|SCA26
Cytomap

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionelongation factor 2epididymis secretory sperm binding proteinpolypeptidyl-tRNA translocaseelongation factor 2epididymis secretory sperm binding proteinpolypeptidyl-tRNA translocase
Modification date2020031320200313
UniProtAcc

P13639

Q96G04

Ensembl transtripts involved in fusion geneENST00000309311, ENST00000600720, 
ENST00000309311, ENST00000600720, 
Fusion gene scores* DoF score44 X 37 X 16=2604817 X 23 X 7=2737
# samples 5628
** MAII scorelog2(56/26048*10)=-5.53960196732128
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(28/2737*10)=-3.28909670241999
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EEF2 [Title/Abstract] AND EEF2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEEF2(3981383)-EEF2(3982967), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across EEF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across EEF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ACD580061EEF2chr19

3981383

-EEF2chr19

3982967

-
ChiTaRS5.0N/AAI075687EEF2chr19

3982344

+EEF2chr19

3977241

+
ChiTaRS5.0N/ABE173877EEF2chr19

3977925

-EEF2chr19

3982305

-
ChiTaRS5.0N/ABE763496EEF2chr19

3980915

+EEF2chr19

3976336

+
ChiTaRS5.0N/ABF761203EEF2chr19

3976742

+EEF2chr19

3980695

-
ChiTaRS5.0N/ABF801948EEF2chr19

3978117

-EEF2chr19

3979344

+
ChiTaRS5.0N/ABF927334EEF2chr19

3976340

-EEF2chr19

3984194

-
ChiTaRS5.0N/ABG031663EEF2chr19

3976181

+EEF2chr19

3976433

-
ChiTaRS5.0N/ABQ347823EEF2chr19

3976563

-EEF2chr19

3976441

+
ChiTaRS5.0N/ABQ349979EEF2chr19

3980548

+EEF2chr19

3985461

-
ChiTaRS5.0N/ACN263823EEF2chr19

3976672

+EEF2chr19

3976591

-
ChiTaRS5.0N/ACN271708EEF2chr19

3981383

-EEF2chr19

3982967

-
ChiTaRS5.0N/AEC450536EEF2chr19

3980048

+EEF2chr19

3980523

-


Top

Fusion Gene ORF analysis for EEF2-EEF2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000309311ENST00000309311EEF2chr19

3981383

-EEF2chr19

3982967

-
intron-intronENST00000309311ENST00000600720EEF2chr19

3981383

-EEF2chr19

3982967

-
intron-3CDSENST00000600720ENST00000309311EEF2chr19

3981383

-EEF2chr19

3982967

-
intron-intronENST00000600720ENST00000600720EEF2chr19

3981383

-EEF2chr19

3982967

-
intron-3CDSENST00000309311ENST00000309311EEF2chr19

3982344

+EEF2chr19

3977241

+
intron-intronENST00000309311ENST00000600720EEF2chr19

3982344

+EEF2chr19

3977241

+
intron-3CDSENST00000600720ENST00000309311EEF2chr19

3982344

+EEF2chr19

3977241

+
intron-intronENST00000600720ENST00000600720EEF2chr19

3982344

+EEF2chr19

3977241

+
intron-3CDSENST00000309311ENST00000309311EEF2chr19

3977925

-EEF2chr19

3982305

-
intron-intronENST00000309311ENST00000600720EEF2chr19

3977925

-EEF2chr19

3982305

-
intron-3CDSENST00000600720ENST00000309311EEF2chr19

3977925

-EEF2chr19

3982305

-
intron-intronENST00000600720ENST00000600720EEF2chr19

3977925

-EEF2chr19

3982305

-
intron-3UTRENST00000309311ENST00000309311EEF2chr19

3980915

+EEF2chr19

3976336

+
intron-intronENST00000309311ENST00000600720EEF2chr19

3980915

+EEF2chr19

3976336

+
intron-3UTRENST00000600720ENST00000309311EEF2chr19

3980915

+EEF2chr19

3976336

+
intron-intronENST00000600720ENST00000600720EEF2chr19

3980915

+EEF2chr19

3976336

+
intron-3CDSENST00000309311ENST00000309311EEF2chr19

3976742

+EEF2chr19

3980695

-
intron-intronENST00000309311ENST00000600720EEF2chr19

3976742

+EEF2chr19

3980695

-
intron-3CDSENST00000600720ENST00000309311EEF2chr19

3976742

+EEF2chr19

3980695

-
intron-intronENST00000600720ENST00000600720EEF2chr19

3976742

+EEF2chr19

3980695

-
intron-3CDSENST00000309311ENST00000309311EEF2chr19

3978117

-EEF2chr19

3979344

+
intron-intronENST00000309311ENST00000600720EEF2chr19

3978117

-EEF2chr19

3979344

+
intron-3CDSENST00000600720ENST00000309311EEF2chr19

3978117

-EEF2chr19

3979344

+
intron-intronENST00000600720ENST00000600720EEF2chr19

3978117

-EEF2chr19

3979344

+
intron-3CDSENST00000309311ENST00000309311EEF2chr19

3976340

-EEF2chr19

3984194

-
intron-5UTRENST00000309311ENST00000600720EEF2chr19

3976340

-EEF2chr19

3984194

-
intron-3CDSENST00000600720ENST00000309311EEF2chr19

3976340

-EEF2chr19

3984194

-
intron-5UTRENST00000600720ENST00000600720EEF2chr19

3976340

-EEF2chr19

3984194

-
intron-3UTRENST00000309311ENST00000309311EEF2chr19

3976181

+EEF2chr19

3976433

-
intron-intronENST00000309311ENST00000600720EEF2chr19

3976181

+EEF2chr19

3976433

-
intron-3UTRENST00000600720ENST00000309311EEF2chr19

3976181

+EEF2chr19

3976433

-
intron-intronENST00000600720ENST00000600720EEF2chr19

3976181

+EEF2chr19

3976433

-
intron-3UTRENST00000309311ENST00000309311EEF2chr19

3976563

-EEF2chr19

3976441

+
intron-intronENST00000309311ENST00000600720EEF2chr19

3976563

-EEF2chr19

3976441

+
intron-3UTRENST00000600720ENST00000309311EEF2chr19

3976563

-EEF2chr19

3976441

+
intron-intronENST00000600720ENST00000600720EEF2chr19

3976563

-EEF2chr19

3976441

+
intron-3CDSENST00000309311ENST00000309311EEF2chr19

3980548

+EEF2chr19

3985461

-
intron-intronENST00000309311ENST00000600720EEF2chr19

3980548

+EEF2chr19

3985461

-
intron-3CDSENST00000600720ENST00000309311EEF2chr19

3980548

+EEF2chr19

3985461

-
intron-intronENST00000600720ENST00000600720EEF2chr19

3980548

+EEF2chr19

3985461

-
intron-3CDSENST00000309311ENST00000309311EEF2chr19

3976672

+EEF2chr19

3976591

-
intron-intronENST00000309311ENST00000600720EEF2chr19

3976672

+EEF2chr19

3976591

-
intron-3CDSENST00000600720ENST00000309311EEF2chr19

3976672

+EEF2chr19

3976591

-
intron-intronENST00000600720ENST00000600720EEF2chr19

3976672

+EEF2chr19

3976591

-
intron-3CDSENST00000309311ENST00000309311EEF2chr19

3980048

+EEF2chr19

3980523

-
intron-intronENST00000309311ENST00000600720EEF2chr19

3980048

+EEF2chr19

3980523

-
intron-3CDSENST00000600720ENST00000309311EEF2chr19

3980048

+EEF2chr19

3980523

-
intron-intronENST00000600720ENST00000600720EEF2chr19

3980048

+EEF2chr19

3980523

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for EEF2-EEF2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for EEF2-EEF2


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EEF2

P13639

EEF2

Q96G04

FUNCTION: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.FUNCTION: Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on 'Lys-525'. {ECO:0000269|PubMed:25231979}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for EEF2-EEF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for EEF2-EEF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for EEF2-EEF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneEEF2P13639DB11823EsketamineInhibitorSmall moleculeApproved|Investigational
HgeneEEF2P13639DB11823EsketamineInhibitorSmall moleculeApproved|Investigational
HgeneEEF2P13639DB12688Moxetumomab PasudotoxInactivatorBiotechApproved|Investigational
HgeneEEF2P13639DB12688Moxetumomab PasudotoxInactivatorBiotechApproved|Investigational

Top

Related Diseases for EEF2-EEF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEEF2C0001418Adenocarcinoma1CTD_human
HgeneEEF2C0006142Malignant neoplasm of breast1CTD_human
HgeneEEF2C0007134Renal Cell Carcinoma1CTD_human
HgeneEEF2C0024121Lung Neoplasms1CTD_human
HgeneEEF2C0027626Neoplasm Invasiveness1CTD_human
HgeneEEF2C0027627Neoplasm Metastasis1CTD_human
HgeneEEF2C0029408Degenerative polyarthritis1CTD_human
HgeneEEF2C0086743Osteoarthrosis Deformans1CTD_human
HgeneEEF2C0205641Adenocarcinoma, Basal Cell1CTD_human
HgeneEEF2C0205642Adenocarcinoma, Oxyphilic1CTD_human
HgeneEEF2C0205643Carcinoma, Cribriform1CTD_human
HgeneEEF2C0205644Carcinoma, Granular Cell1CTD_human
HgeneEEF2C0205645Adenocarcinoma, Tubular1CTD_human
HgeneEEF2C0242379Malignant neoplasm of lung1CTD_human
HgeneEEF2C0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
HgeneEEF2C0678222Breast Carcinoma1CTD_human
HgeneEEF2C1257931Mammary Neoplasms, Human1CTD_human
HgeneEEF2C1266042Chromophobe Renal Cell Carcinoma1CTD_human
HgeneEEF2C1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
HgeneEEF2C1266044Collecting Duct Carcinoma of the Kidney1CTD_human
HgeneEEF2C1306837Papillary Renal Cell Carcinoma1CTD_human
HgeneEEF2C1458155Mammary Neoplasms1CTD_human
HgeneEEF2C1836395SPINOCEREBELLAR ATAXIA 261CTD_human;ORPHANET;UNIPROT
HgeneEEF2C4704874Mammary Carcinoma, Human1CTD_human
TgeneEEF2C0001418Adenocarcinoma1CTD_human
TgeneEEF2C0006142Malignant neoplasm of breast1CTD_human
TgeneEEF2C0007134Renal Cell Carcinoma1CTD_human
TgeneEEF2C0024121Lung Neoplasms1CTD_human
TgeneEEF2C0027626Neoplasm Invasiveness1CTD_human
TgeneEEF2C0027627Neoplasm Metastasis1CTD_human
TgeneEEF2C0029408Degenerative polyarthritis1CTD_human
TgeneEEF2C0086743Osteoarthrosis Deformans1CTD_human
TgeneEEF2C0205641Adenocarcinoma, Basal Cell1CTD_human
TgeneEEF2C0205642Adenocarcinoma, Oxyphilic1CTD_human
TgeneEEF2C0205643Carcinoma, Cribriform1CTD_human
TgeneEEF2C0205644Carcinoma, Granular Cell1CTD_human
TgeneEEF2C0205645Adenocarcinoma, Tubular1CTD_human
TgeneEEF2C0242379Malignant neoplasm of lung1CTD_human
TgeneEEF2C0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
TgeneEEF2C0678222Breast Carcinoma1CTD_human
TgeneEEF2C1257931Mammary Neoplasms, Human1CTD_human
TgeneEEF2C1266042Chromophobe Renal Cell Carcinoma1CTD_human
TgeneEEF2C1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TgeneEEF2C1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TgeneEEF2C1306837Papillary Renal Cell Carcinoma1CTD_human
TgeneEEF2C1458155Mammary Neoplasms1CTD_human
TgeneEEF2C1836395SPINOCEREBELLAR ATAXIA 261CTD_human;ORPHANET;UNIPROT
TgeneEEF2C4704874Mammary Carcinoma, Human1CTD_human