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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:EFEMP2-C6orf132 (FusionGDB2 ID:25312) |
Fusion Gene Summary for EFEMP2-C6orf132 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EFEMP2-C6orf132 | Fusion gene ID: 25312 | Hgene | Tgene | Gene symbol | EFEMP2 | C6orf132 | Gene ID | 30008 | 647024 |
| Gene name | EGF containing fibulin extracellular matrix protein 2 | chromosome 6 open reading frame 132 | |
| Synonyms | ARCL1B|FBLN4|MBP1|UPH1 | bA7K24.2 | |
| Cytomap | 11q13.1 | 6p21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | EGF-containing fibulin-like extracellular matrix protein 2EGF containing fibulin like extracellular matrix protein 2FIBL-4fibulin 4mutant p53 binding protein 1 | uncharacterized protein C6orf132 | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | O95967 | Q5T0Z8 | |
| Ensembl transtripts involved in fusion gene | ENST00000528176, ENST00000307998, ENST00000532648, | ENST00000341865, ENST00000356542, | |
| Fusion gene scores | * DoF score | 1 X 2 X 1=2 | 8 X 7 X 5=280 |
| # samples | 2 | 12 | |
| ** MAII score | log2(2/2*10)=3.32192809488736 | log2(12/280*10)=-1.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EFEMP2 [Title/Abstract] AND C6orf132 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | EFEMP2(65637328)-C6orf132(42096516), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across EFEMP2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across C6orf132 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-BR-8590-01A | EFEMP2 | chr11 | 65637328 | - | C6orf132 | chr6 | 42096516 | - |
| ChimerDB4 | STAD | TCGA-BR-8590 | EFEMP2 | chr11 | 65637327 | - | C6orf132 | chr6 | 42096516 | - |
| ChimerDB4 | STAD | TCGA-BR-8590-01A | EFEMP2 | chr11 | 65637328 | - | C6orf132 | chr6 | 42096516 | - |
| ChimerDB4 | STAD | TCGA-BR-8590-01A | EFEMP2 | chr11 | 65637328 | - | C6orf132 | chr6 | 42096516 | - |
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Fusion Gene ORF analysis for EFEMP2-C6orf132 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000528176 | ENST00000341865 | EFEMP2 | chr11 | 65637328 | - | C6orf132 | chr6 | 42096516 | - |
| In-frame | ENST00000528176 | ENST00000356542 | EFEMP2 | chr11 | 65637328 | - | C6orf132 | chr6 | 42096516 | - |
| In-frame | ENST00000307998 | ENST00000341865 | EFEMP2 | chr11 | 65637328 | - | C6orf132 | chr6 | 42096516 | - |
| In-frame | ENST00000307998 | ENST00000356542 | EFEMP2 | chr11 | 65637328 | - | C6orf132 | chr6 | 42096516 | - |
| intron-3CDS | ENST00000532648 | ENST00000341865 | EFEMP2 | chr11 | 65637328 | - | C6orf132 | chr6 | 42096516 | - |
| intron-3CDS | ENST00000532648 | ENST00000356542 | EFEMP2 | chr11 | 65637328 | - | C6orf132 | chr6 | 42096516 | - |
| In-frame | ENST00000528176 | ENST00000341865 | EFEMP2 | chr11 | 65637327 | - | C6orf132 | chr6 | 42096516 | - |
| In-frame | ENST00000528176 | ENST00000356542 | EFEMP2 | chr11 | 65637327 | - | C6orf132 | chr6 | 42096516 | - |
| In-frame | ENST00000307998 | ENST00000341865 | EFEMP2 | chr11 | 65637327 | - | C6orf132 | chr6 | 42096516 | - |
| In-frame | ENST00000307998 | ENST00000356542 | EFEMP2 | chr11 | 65637327 | - | C6orf132 | chr6 | 42096516 | - |
| intron-3CDS | ENST00000532648 | ENST00000341865 | EFEMP2 | chr11 | 65637327 | - | C6orf132 | chr6 | 42096516 | - |
| intron-3CDS | ENST00000532648 | ENST00000356542 | EFEMP2 | chr11 | 65637327 | - | C6orf132 | chr6 | 42096516 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000528176 | EFEMP2 | chr11 | 65637328 | - | ENST00000341865 | C6orf132 | chr6 | 42096516 | - | 6860 | 795 | 68 | 4216 | 1382 |
| ENST00000528176 | EFEMP2 | chr11 | 65637328 | - | ENST00000356542 | C6orf132 | chr6 | 42096516 | - | 1369 | 795 | 68 | 949 | 293 |
| ENST00000307998 | EFEMP2 | chr11 | 65637328 | - | ENST00000341865 | C6orf132 | chr6 | 42096516 | - | 7023 | 958 | 111 | 4379 | 1422 |
| ENST00000307998 | EFEMP2 | chr11 | 65637328 | - | ENST00000356542 | C6orf132 | chr6 | 42096516 | - | 1532 | 958 | 111 | 1112 | 333 |
| ENST00000528176 | EFEMP2 | chr11 | 65637327 | - | ENST00000341865 | C6orf132 | chr6 | 42096516 | - | 6860 | 795 | 68 | 4216 | 1382 |
| ENST00000528176 | EFEMP2 | chr11 | 65637327 | - | ENST00000356542 | C6orf132 | chr6 | 42096516 | - | 1369 | 795 | 68 | 949 | 293 |
| ENST00000307998 | EFEMP2 | chr11 | 65637327 | - | ENST00000341865 | C6orf132 | chr6 | 42096516 | - | 7023 | 958 | 111 | 4379 | 1422 |
| ENST00000307998 | EFEMP2 | chr11 | 65637327 | - | ENST00000356542 | C6orf132 | chr6 | 42096516 | - | 1532 | 958 | 111 | 1112 | 333 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000528176 | ENST00000341865 | EFEMP2 | chr11 | 65637328 | - | C6orf132 | chr6 | 42096516 | - | 0.001682166 | 0.99831784 |
| ENST00000528176 | ENST00000356542 | EFEMP2 | chr11 | 65637328 | - | C6orf132 | chr6 | 42096516 | - | 0.013409892 | 0.98659015 |
| ENST00000307998 | ENST00000341865 | EFEMP2 | chr11 | 65637328 | - | C6orf132 | chr6 | 42096516 | - | 0.00196672 | 0.9980332 |
| ENST00000307998 | ENST00000356542 | EFEMP2 | chr11 | 65637328 | - | C6orf132 | chr6 | 42096516 | - | 0.010692325 | 0.9893077 |
| ENST00000528176 | ENST00000341865 | EFEMP2 | chr11 | 65637327 | - | C6orf132 | chr6 | 42096516 | - | 0.001682166 | 0.99831784 |
| ENST00000528176 | ENST00000356542 | EFEMP2 | chr11 | 65637327 | - | C6orf132 | chr6 | 42096516 | - | 0.013409892 | 0.98659015 |
| ENST00000307998 | ENST00000341865 | EFEMP2 | chr11 | 65637327 | - | C6orf132 | chr6 | 42096516 | - | 0.00196672 | 0.9980332 |
| ENST00000307998 | ENST00000356542 | EFEMP2 | chr11 | 65637327 | - | C6orf132 | chr6 | 42096516 | - | 0.010692325 | 0.9893077 |
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Fusion Genomic Features for EFEMP2-C6orf132 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for EFEMP2-C6orf132 |
| Go to FGviewer for the breakpoints of chr11:65637328-chr6:42096516 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EFEMP2 | C6orf132 |
| FUNCTION: Plays a crucial role in elastic fiber formation in tissue, and in the formation of ultrastructural connections between elastic laminae and smooth muscle cells in the aorta, therefore participates in terminal differentiation and maturation of smooth muscle cell (SMC) and in the mechanical properties and wall integrity maintenance of the aorta (PubMed:27339457). In addition, is involved in the control of collagen fibril assembly in tissue throught proteolytic activation of LOX leading to cross- linking of collagen and elastin (By similarity). Also promotes ELN coacervation and participates in the deposition of ELN coacervates on to microfibrils but also regulates ELN cross- linking through LOX interaction (PubMed:18973305, PubMed:19570982). Moreover adheres to the cells through heparin binding in a calcium-dependent manner and regulates vascularlar smooth muscle cells proliferation through angiotensin signaling (PubMed:23782690). {ECO:0000250|UniProtKB:Q9WVJ9, ECO:0000269|PubMed:18973305, ECO:0000269|PubMed:19570982, ECO:0000269|PubMed:23782690, ECO:0000269|PubMed:27339457}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | EFEMP2 | chr11:65637327 | chr6:42096516 | ENST00000307998 | - | 7 | 11 | 123_163 | 242.33333333333334 | 444.0 | Domain | EGF-like 2%3B calcium-binding |
| Hgene | EFEMP2 | chr11:65637327 | chr6:42096516 | ENST00000307998 | - | 7 | 11 | 164_202 | 242.33333333333334 | 444.0 | Domain | EGF-like 3%3B calcium-binding |
| Hgene | EFEMP2 | chr11:65637327 | chr6:42096516 | ENST00000307998 | - | 7 | 11 | 203_242 | 242.33333333333334 | 444.0 | Domain | EGF-like 4%3B calcium-binding |
| Hgene | EFEMP2 | chr11:65637327 | chr6:42096516 | ENST00000307998 | - | 7 | 11 | 36_81 | 242.33333333333334 | 444.0 | Domain | EGF-like 1%3B atypical |
| Hgene | EFEMP2 | chr11:65637328 | chr6:42096516 | ENST00000307998 | - | 7 | 11 | 123_163 | 242.33333333333334 | 444.0 | Domain | EGF-like 2%3B calcium-binding |
| Hgene | EFEMP2 | chr11:65637328 | chr6:42096516 | ENST00000307998 | - | 7 | 11 | 164_202 | 242.33333333333334 | 444.0 | Domain | EGF-like 3%3B calcium-binding |
| Hgene | EFEMP2 | chr11:65637328 | chr6:42096516 | ENST00000307998 | - | 7 | 11 | 203_242 | 242.33333333333334 | 444.0 | Domain | EGF-like 4%3B calcium-binding |
| Hgene | EFEMP2 | chr11:65637328 | chr6:42096516 | ENST00000307998 | - | 7 | 11 | 36_81 | 242.33333333333334 | 444.0 | Domain | EGF-like 1%3B atypical |
| Tgene | C6orf132 | chr11:65637327 | chr6:42096516 | ENST00000341865 | 0 | 5 | 140_185 | 48.333333333333336 | 1189.0 | Compositional bias | Note=Pro-rich | |
| Tgene | C6orf132 | chr11:65637327 | chr6:42096516 | ENST00000356542 | 0 | 3 | 140_185 | 48.333333333333336 | 100.0 | Compositional bias | Note=Pro-rich | |
| Tgene | C6orf132 | chr11:65637328 | chr6:42096516 | ENST00000341865 | 0 | 5 | 140_185 | 48.333333333333336 | 1189.0 | Compositional bias | Note=Pro-rich | |
| Tgene | C6orf132 | chr11:65637328 | chr6:42096516 | ENST00000356542 | 0 | 3 | 140_185 | 48.333333333333336 | 100.0 | Compositional bias | Note=Pro-rich |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | EFEMP2 | chr11:65637327 | chr6:42096516 | ENST00000307998 | - | 7 | 11 | 243_282 | 242.33333333333334 | 444.0 | Domain | EGF-like 5%3B calcium-binding |
| Hgene | EFEMP2 | chr11:65637327 | chr6:42096516 | ENST00000307998 | - | 7 | 11 | 283_328 | 242.33333333333334 | 444.0 | Domain | EGF-like 6%3B calcium-binding |
| Hgene | EFEMP2 | chr11:65637328 | chr6:42096516 | ENST00000307998 | - | 7 | 11 | 243_282 | 242.33333333333334 | 444.0 | Domain | EGF-like 5%3B calcium-binding |
| Hgene | EFEMP2 | chr11:65637328 | chr6:42096516 | ENST00000307998 | - | 7 | 11 | 283_328 | 242.33333333333334 | 444.0 | Domain | EGF-like 6%3B calcium-binding |
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Fusion Gene Sequence for EFEMP2-C6orf132 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000528176_ENST00000341865_TCGA-BR-8590-01A_EFEMP2_chr11_65637328_-_C6orf132_chr6_42096516_length(transcript)=6860nt_BP=795nt GGCATTGCCCGAGCCAGCCGAGCCGCCAGAGCCGCGGGCCGCGGGGGTGTCGCGGGCCCAACCCCAGGATGCTCCCCTGCGCCTCCTGCC TACCCGGGTCTCTACTGCTCTGGGCGCTGCTACTGTTGCTCTTGGGATCAGCTTCTCCTCAGGATTCTGAAGAGCCCGACAGCTACACGG AATGCACAGATGGCTATGAGTGGGACCCAGACAGCCAGCACTGCCGGGATGTCAACGAGTGTCTGACCATCCCTGAGGCCTGCAAGGGGG AAATGAAGTGCATCAACCACTACGGGGGCTACTTGTGCCTGCCCCGCTCCGCTGCCGTCATCAACGACCTACACGGCGAGGGACCCCCGC CACCAGTGCCTCCCGCTCAACACCCCAACCCCTGCCCACCAGGCTATGAGCCCGACGATCAGGACAGCTGTGTGGATGTGGACGAGTGTG CCCAGGCCCTGCACGACTGTCGCCCCAGCCAGGACTGCCATAACTTGCCTGGCTCCTATCAGTGCACCTGCCCTGATGGTTACCGCAAGA TCGGGCCCGAGTGTGTGGACATAGACGAGTGCCGCTACCGCTACTGCCAGCACCGCTGCGTGAACCTGCCTGGCTCCTTCCGCTGCCAGT GCGAGCCGGGCTTCCAGCTGGGGCCTAACAACCGCTCCTGTGTTGATGTGAACGAGTGTGACATGGGGGCCCCATGCGAGCAGCGCTGCT TCAACTCCTATGGGACCTTCCTGTGTCGCTGCCACCAGGGCTATGAGCTGCATCGGGATGGCTTCTCCTGCAGTGATGGCATCTATTATG GAGACAATCGGTTTAACACAGTGAGCGAGTCAGGAACAGCCACGCTGAAAGCTCGGCCAAGAGTCCGGCCCCTGCTGACCTTCCTTCCGC TGAATGCCCAGGAAAACCATGGGCTGGCTGTGCCCACCCCCTCGGTTCCAGATGATTTTGCAGACAAAGAAGTGACAGGTACCAGCTCAC TAGTCAATGGCAACCTCCGACTGTACAGCTCTGTGGGTGACCTGAGGCCTGGACAATATGGCCAGGATCTACTCATCCCCCCACCTCCCC CAGGCCCAGCCCCAGGGCCCCCTCAGGACATTTCAGAACCTCCAGGGGGGTCGCCACTGCCATCTCCACCTTCCACAGCACCCCCACCAC CTCCCCTGCTGCTGGAACCCCCACCCCCGCCCAGCATGGCCCCACCTCCACCCCCAGTATTGGAGGCCCTATCCCCACCACACACTCTTT CCTCCCCATCCATACCCACCCCTCCTGACTTCATTCCCCCTGCCCCACCCTTGGCCTTTCTAGCCCCCCCACCGCCTCCTGTGCCAGCCC CAGCACCCCCAGCTCCAGCATCTCCTCACACAGTGGGGACTCGTCTCTTTCCCCCTGGGGGTGTCACCAAGTGGAAATCAGATGTAGCAC TGAATGGCAGGCAGGCAGAGGCCACCAGAGCCAGCCCCCCGAGAAGCCCTGCTGAGCCAAAGGGGAGCGCCCTGGGACCTAACCCAGAGC CCCATCTCACCTTCCCCCGTTCTTTCAAAGTGCCTCCCCCAACCCCAGTCAGGACTTCGTCCATCCCAGTTCAGGAAGCACAAGAGGCTC CCCGAAAGGAAGAGGGGGCCACCAAGAAGGCTCCCAGCCGACTCCCACTGCCTCCCAGCTTCCACATCCGCCCCGCCTCCCAGGTCTACC CAGACAGGGCCCCCGAGCCAGACTGCCCTGGGGAGCTCAAGGCCACAGCACCAGCCAGCCCAAGGCTTGGCCAGTCCCAGTCCCAAGCAG ATGAACGAGCTGGGACTCCGCCTCCAGCCCCTCCCCTGCCCCCTCCTGCACCCCCCCTCCCTCCCCCAGCACCCCCACTTCCCCCAGCTG CACCTCCTTTGCCCTGTGCTCAGAAGGCAGCCCATCCACCTGCTGGGTTTACAAAAACCCCTAAATCCAGCTCTCCTGCTCTCAAACCCA AACCCAACCCCCCCAGCCCAGAGAACACAGCGTCTTCAGCACCTGTGGACTGGAGGGACCCCAGCCAGATGGAAAAGCTGCGGAACGAGC TGGCAGCCTATCTCTGTGGCTCCAGGAGAGAGGACCGATTCCTCAGTCACAGGCCAGGCCCAACAGTGGCCCCTCAGAGCAAGGAGGGCA AGAAGGGCCCCCGCCTGCCTGAGAAGGAGACTCTCCTGAGCCTGCCAGCAAAGGACACTCCCCCAGGTGTTCCTGAAAAGAGTCTTGGCG GCAGCAGCCTGACAGAGACAGAGGCTGCCCCCAGCCTGACCCTGCCCTCTGTGGACTACATTCCCCAAGACTCTCCAACTCCCAGTGTGC GGCAGATCCGGAATGAGCTGGAGGCCCGGCTCTCCTCAGCAGCAGAGAAGGAGGCTAAGCCCAGCATAGGATCTCTGCCCCCTAAGCCTC GGCTAGAAGGGGGAAGAATTTGTGAAAACGGGGCTGATGATGACAAACTCTCCAAGCCTGTGGCCAAGAATCTGCCACCTCAATCCACCA CCCTGCTGCCAACTACATCACTCCAGCCCAAGGCTATGTTGGGACCAGCCATACCACCCAAGGCCACACCTGAGCCAGCCATACCACCCA AGGCTACACTTTGGCCAGCCACACCACCCAAGGCCACACTTGGGCCAGCCACACCACTCAAGGCCACATCTGGGCCAACCACACCACTCA AGGCCACATCTGGCCCTGCCATAGCATCTACAGCCACAACTCTGCCCACCACCACATCCCAACTGATGGCAGAGAAGGACTCAGGCCCAG CTGGCCAGCCAGAGAAGCCAGCATCTCAAGAAGTTTCCACTCCCTCCCAGGCAAGGGGAGAGGGGTCCCCCTCAGAGGCCACTAGGCTGC CCACACAGGGAGCCCGCTCATCTGCAGCCTTCCCACCAAAGACATCTCCTGGTGGAGGAGAGGTGCCATGTCTCTACAAGCCCCACTGCC ACCAGAGCAGCCTCAGCCGTGAGGTTGCTGTGGTGATGCCCACCCTGGCCAGAGGAGGGGCTGCAGGGCCAGGGGAGCCCGTGGAGGTGA AGGAGCCCCCAGGGCTGCCAGCCAAGCCTCCTGCCTCGGCCCAGCCCACTGATGAACTCCTCAGGCACCCGGTGACTGGGGAGGTGGTGG AGCGGGGCTCGCCGATGGCCCTGCTCCTGGCGGCCAGGCAGAGGGCTCAGAAGGGAAGGTCTGTAGGGGCTGCCCTGGGTCGGTCCTCTC TGCCAGGAAGTCTCCGTGACCACAGCCACCAAGCCGAGGCCAGCTCTGACAGCATCTTCCACAGCCAGGGCACGCCCAACTCCTTCACTG TGGTGCCCAAGTTACCCAAGGAGGCTGAGAAGGACTCCCCGCTGACGACCGAAATACCCAATAAGTGGGGGCCGCGGCTGGGAAGAGACG CAGAGGGCACAGAGCTGAGCCGCAGGCACAACTGGACAAAGCCAGAGCCCCAGGCCCCTGTGGCCTGGGAAAGAGTAGCTCCCTCCAACC TCCCCCAGGGCCACCCGCTGCCCAAGTCCTTCTCCTCCCCACCTTCTCCTTCGAACAAGAGGGAGGAGGAGGAGGAGGAGTTCAACTTCG AGGTCATCCCACCGCCGCCAGAGTTCAGCAATGACCCTGAGCCCCCGGCCCCGGCCCTCCAGTATCTGGGCCGCCAGAGCTCCCCTCCCC GGAACAACTACTCAGACTTGAGGCAGCTCCCGAACGCTGGCCCCGGGGCGCCCCCGGCTCTCGGCTTCTCGCGCTTTCCCGCGGGCGCGC GCTACGCCGGGGCTGGGGGCCTGGAGCGCTTCTCGGGAGGGGGCCGCTCGCTCATAAAGAAGCGCCTGTACGTCGGGGAGCCGCACCGAG GCCCAGGGCTACCCCACGGTGGCACCGGCCGCAGCCTGAGCTCTCCCAACTGCTTCGGGCCGCAGCCCGGAGGCCCCGAGATGCGGCGCG TGAACTCGGCGGGTCGCGCGCCCCCCGGAGGCCTGCACGCGCCGAGGCTGTCCCTGGAGGGCGCCGCCCGGGGCGCCGCGGAGGCCAAGC ACAAAGCGCCCGGCAGCGCCGACTACGGCTTCGCCCCAGCTGCCGGCAGGTCTCCCTACACCACCACCCGCTATGGAAGCCCCATCAACA CGTTCACCGTGAGGCCTGGGACCCGCCATCCCATCTCCTATGTCTGCTCAGGGGCCCATCGGAAAGCCACCTCCTGAGCCAGGGGTTCTC TTAGCTCTACTCCAACAAACTGTGTCTTTAAGGATCTGGGCACTTGTTTCTTGTGGGGGGTGGGAGGTACACAGCAGGTGTTGGGCGACC TGACTCAGACACAGAGGAGTCTTTGATCCCCAAAGACCAACGATGAGAAGCAGTGGCCCAGGAAGACCGAGAGTGGGCTTCTGTTTCCCA AAGCGCTGGTGTGACTGTGGACTGTTTACACGTGGGGGGTGGGAGGGGAAGGAGGGTAGAGAGAAGGAACCATTAAGGACCTGGGCGCTG AGTTTCTGCTCTCTGGTACTATCTGCTTTAGCAAGAGTTATTTAAAACAGTTTTACAAGCACGGCCTACTGAGCAGGTTCTGAAAGCAAG GGGTGGGGCACTGACTGAACTGGAACCCATCGAGATAGCTGTGATTGCCTGTCAGGCCCTTGCAAAGGGCTGAGGCCCAGCTCTGTCTGG TGGGTGTGCAGGGCACCGAAGGGAGATCTTTAGCCTCCATCACCTGCCATCCCAAGCAAGAGTGGACACCTGGGGTTCCTAGCCGCATTG AGGTGGGACCAGGAATGTGTATGTATAACATGTGGAGAAGGACCATGTGTGGGGTGGGGAGTGAAGCTCCCACATGTGGAATGGAAGCCC TTTGCATTGGCCAAGGGCAGAGGTGGGAGATTGATGGTTCATTTTTCCTTGGCCCTAGCCCTTAGCTACAGGGAGGCCTAGAGAGAGGAC ACTTGGCAAGTTTAGGATGGGAAACAAGGTTAAGCCTGGCTTTGCTATTCAGACCTGTGCAGCCCTGATTTTGGGGACTGGGCCCAAGGA GCCATGAGTCTTAGGCTTGACACTAGGGGCCTTACATGGCCAGGTCTCATATGGGATTTGGAGAAGGCATTTTTCCTAACACTGATACTA CAAGTCACCAATACTCTTGATGCCTTAAGATGCTAGAAAGCCTTGGAGAGTGGAGGCAGCAGAGATGGGAATGGAGGTCTGAAGAAGCTT GCTGCTGTTGGGGAATGTGTTTGGGAAAGTCAAGAGTGGTAGGATTGGTTGGCTGGGCGCGGTGGCTCACACCTGTAATCCCAGCACTTT GGGAGGCCGAGGCCGGTGGATCACTTGAGGTCAGAAGTTCGAGACCAGCCTGCCCAAATGGTGAAACCCCATCTCTACTAAAAATACGGA AAAAAAAAAAAAAAGAGTGCTAGGATTGGGCCAGTTAAGAGCAGGGGAGACCTGGCTGGGCATGGTGGCTCACACCTGTAATTCTAGCAC TTTGGGAGGCTGAGGCGGGTGGATCATGAGGTCAAGAGATTAAGACCATCCTGGCCTACATGGCGAAACCCTGTCTCTACTAAAAATAAA AAAATGACCTGGGCATGGTGGTGGGCGCCTGTAGTCCCAGCTACTCGGGGCGCTGAGGCAGGAGAATCGCTCGAACCCAGGAGGTGGAGG TTGCAGTGAGCCGAGATTGCACAATTGCACTCCAGCCTGGCGACAGAGCGAGACTCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAGGAG CAGGGGAGACCTATCAGTAGGGTGACCACGTGTCCTTTGCCTGGGCAGTCCAGGTTTATGCTTGTTTTCCAGTGAATTAGACCCCCTTCC ACTTTTCAAAAAAGTCCTGGTTTAGATGCTGTGATCACCAAACATATCAGGAAACAATATTCCTTGGTCTTGCTTCCCTATCTTCAGGTA CTGGTGGGCCAAATTCCTGGGACCAGGTCAAGGTGGGCTGCCTCAGTAAGAAGGAAGGACTGGAGAGTGCCCATTTCAGAGGAGCAGGCT GGTGGGGGCCAGCCAGAAAGTAGTTCCCTTTGGGGGGAAGATGTTGGACCTTTATTATTTGTGGTAACCAGCCGAGGCTGGTTGTCAGGA CAGCAGGTGAGCCACTTTAGGGAAGAAAGTGCAGGGGTGGGTGGATGCCCAGATTACCAAGGCCAGCCACCCTGATGGGGTAGGGTCTGG TTATCTGTGTTCAAGAAGCAAATCCCACCCCAGCCCCAGCACTAGCTCTCTATGTATGTATTTTCCCTGTACAATGTTTTATAAAAGAGA TCATTAATTTATCTGCTATGTTAAGGCTCGAGGGGTGGGGCGTAGACTCTCAGCTGTATATTGCTCTGGGGTGGGCAGGGAAGGCTGAGT CTCACTTGACTTGGAAGATAAACAGGCCAGTTTGGACTGGCCTCCAGCTCCGTGGCTGTGTTTGTCTAACAAGGATTTGGGTAACTACTG GATACAAGCCACTGTGCTTAGTATGGATAGACTGCCATCAGCTCACCCACATGACTCCTGTTCATGGCAAGCTAATAGTCTGTCTGGTGG AAGAGGATTGAAAAAGCACACAAAAACATCATAAATTACAAGGAGTAGTAAGAAGGAAAAAACAGGGAACGTGAGAGAATAACTAGCGAG TGGGGAGAGGAGTGGATTTACTTTAACAGGGTAGTCAGGGAAGGCCTCTTGTGGTGGTGACATACTGATTTAGGCAAAGCGTCCAGCACG TGCCTAGCGCTTAGTAGTTGCTCAGCAAATGGCATCTTTGGGTGATGAATACCTCACATTTGTATATGGCCTGTCACAGTTTTCCATAAA >In-frame_ENST00000528176_ENST00000341865_TCGA-BR-8590-01A_EFEMP2_chr11_65637328_-_C6orf132_chr6_42096516_length(amino acids)=1382AA_start in transcript=68_stop in transcript=4216 MLPCASCLPGSLLLWALLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVIND LHGEGPPPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNL PGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDGIYYGDNRFNTVSESGTATLKARPRVR PLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLRLYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSP PSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVT KWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHI RPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKS SSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPG VPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAK NLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLM AEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAG PGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQ GTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREE EEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRL YVGEPHRGPGLPHGGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAPRLSLEGAARGAAEAKHKAPGSADYGFAPAAGRSPYTTT -------------------------------------------------------------- >In-frame_ENST00000528176_ENST00000356542_TCGA-BR-8590-01A_EFEMP2_chr11_65637328_-_C6orf132_chr6_42096516_length(transcript)=1369nt_BP=795nt GGCATTGCCCGAGCCAGCCGAGCCGCCAGAGCCGCGGGCCGCGGGGGTGTCGCGGGCCCAACCCCAGGATGCTCCCCTGCGCCTCCTGCC TACCCGGGTCTCTACTGCTCTGGGCGCTGCTACTGTTGCTCTTGGGATCAGCTTCTCCTCAGGATTCTGAAGAGCCCGACAGCTACACGG AATGCACAGATGGCTATGAGTGGGACCCAGACAGCCAGCACTGCCGGGATGTCAACGAGTGTCTGACCATCCCTGAGGCCTGCAAGGGGG AAATGAAGTGCATCAACCACTACGGGGGCTACTTGTGCCTGCCCCGCTCCGCTGCCGTCATCAACGACCTACACGGCGAGGGACCCCCGC CACCAGTGCCTCCCGCTCAACACCCCAACCCCTGCCCACCAGGCTATGAGCCCGACGATCAGGACAGCTGTGTGGATGTGGACGAGTGTG CCCAGGCCCTGCACGACTGTCGCCCCAGCCAGGACTGCCATAACTTGCCTGGCTCCTATCAGTGCACCTGCCCTGATGGTTACCGCAAGA TCGGGCCCGAGTGTGTGGACATAGACGAGTGCCGCTACCGCTACTGCCAGCACCGCTGCGTGAACCTGCCTGGCTCCTTCCGCTGCCAGT GCGAGCCGGGCTTCCAGCTGGGGCCTAACAACCGCTCCTGTGTTGATGTGAACGAGTGTGACATGGGGGCCCCATGCGAGCAGCGCTGCT TCAACTCCTATGGGACCTTCCTGTGTCGCTGCCACCAGGGCTATGAGCTGCATCGGGATGGCTTCTCCTGCAGTGATGGCATCTATTATG GAGACAATCGGTTTAACACAGTGAGCGAGTCAGGAACAGCCACGCTGAAAGCTCGGCCAAGAGTCCGGCCCCTGCTGACCTTCCTTCCGC TGACTGAGTTTCATTCTTGTTGCCCAGGCTGGAGTGGTACAATGGCGTGATCTCGGCTCCCTGCAACCTCCACCTCCTGGGTTCAAGCGA TTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTGCCCACCACCATGCCCGGCAAATTTTTTGTATTTTTAGTAGAGACAGGGT TTCACCATTTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACAAACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGA GCTACCGCGCCCAGCCTGAAATACTCTATATTGGGAGGTTAATTAGATTCTCTCCTATCACTTACCCTCAGCACACATACCCAGATTCAT AGCAGTGTGGGCCCAGAGTTGACACACCTCTACCAGTCGGTAAAATACTAAAACATTCATCTGTAAAATGGGAATAAAAAAAAAAAAACA >In-frame_ENST00000528176_ENST00000356542_TCGA-BR-8590-01A_EFEMP2_chr11_65637328_-_C6orf132_chr6_42096516_length(amino acids)=293AA_start in transcript=68_stop in transcript=949 MLPCASCLPGSLLLWALLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVIND LHGEGPPPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNL PGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDGIYYGDNRFNTVSESGTATLKARPRVR -------------------------------------------------------------- >In-frame_ENST00000307998_ENST00000341865_TCGA-BR-8590-01A_EFEMP2_chr11_65637328_-_C6orf132_chr6_42096516_length(transcript)=7023nt_BP=958nt GCGGGGGGTCGGGGTCCCTCCCCCTGGCGCTGGCTCAGGAATCCGCCGAAGGGCGGGCGGAGGCGCCGGGGTGGGCCGCGCCGCGGCAGG CGGGCGGGCGGGGGGCGCTTCCTGGGGCCGCGCGTCCAGGGAGCTGTGCCGTCCGCCCGTCCGTCTGCCCGCAGGCATTGCCCGAGCCAG CCGAGCCGCCAGAGCCGCGGGCCGCGGGGGTGTCGCGGGCCCAACCCCAGGATGCTCCCCTGCGCCTCCTGCCTACCCGGGTCTCTACTG CTCTGGGCGCTGCTACTGTTGCTCTTGGGATCAGCTTCTCCTCAGGATTCTGAAGAGCCCGACAGCTACACGGAATGCACAGATGGCTAT GAGTGGGACCCAGACAGCCAGCACTGCCGGGATGTCAACGAGTGTCTGACCATCCCTGAGGCCTGCAAGGGGGAAATGAAGTGCATCAAC CACTACGGGGGCTACTTGTGCCTGCCCCGCTCCGCTGCCGTCATCAACGACCTACACGGCGAGGGACCCCCGCCACCAGTGCCTCCCGCT CAACACCCCAACCCCTGCCCACCAGGCTATGAGCCCGACGATCAGGACAGCTGTGTGGATGTGGACGAGTGTGCCCAGGCCCTGCACGAC TGTCGCCCCAGCCAGGACTGCCATAACTTGCCTGGCTCCTATCAGTGCACCTGCCCTGATGGTTACCGCAAGATCGGGCCCGAGTGTGTG GACATAGACGAGTGCCGCTACCGCTACTGCCAGCACCGCTGCGTGAACCTGCCTGGCTCCTTCCGCTGCCAGTGCGAGCCGGGCTTCCAG CTGGGGCCTAACAACCGCTCCTGTGTTGATGTGAACGAGTGTGACATGGGGGCCCCATGCGAGCAGCGCTGCTTCAACTCCTATGGGACC TTCCTGTGTCGCTGCCACCAGGGCTATGAGCTGCATCGGGATGGCTTCTCCTGCAGTGATGGCATCTATTATGGAGACAATCGGTTTAAC ACAGTGAGCGAGTCAGGAACAGCCACGCTGAAAGCTCGGCCAAGAGTCCGGCCCCTGCTGACCTTCCTTCCGCTGAATGCCCAGGAAAAC CATGGGCTGGCTGTGCCCACCCCCTCGGTTCCAGATGATTTTGCAGACAAAGAAGTGACAGGTACCAGCTCACTAGTCAATGGCAACCTC CGACTGTACAGCTCTGTGGGTGACCTGAGGCCTGGACAATATGGCCAGGATCTACTCATCCCCCCACCTCCCCCAGGCCCAGCCCCAGGG CCCCCTCAGGACATTTCAGAACCTCCAGGGGGGTCGCCACTGCCATCTCCACCTTCCACAGCACCCCCACCACCTCCCCTGCTGCTGGAA CCCCCACCCCCGCCCAGCATGGCCCCACCTCCACCCCCAGTATTGGAGGCCCTATCCCCACCACACACTCTTTCCTCCCCATCCATACCC ACCCCTCCTGACTTCATTCCCCCTGCCCCACCCTTGGCCTTTCTAGCCCCCCCACCGCCTCCTGTGCCAGCCCCAGCACCCCCAGCTCCA GCATCTCCTCACACAGTGGGGACTCGTCTCTTTCCCCCTGGGGGTGTCACCAAGTGGAAATCAGATGTAGCACTGAATGGCAGGCAGGCA GAGGCCACCAGAGCCAGCCCCCCGAGAAGCCCTGCTGAGCCAAAGGGGAGCGCCCTGGGACCTAACCCAGAGCCCCATCTCACCTTCCCC CGTTCTTTCAAAGTGCCTCCCCCAACCCCAGTCAGGACTTCGTCCATCCCAGTTCAGGAAGCACAAGAGGCTCCCCGAAAGGAAGAGGGG GCCACCAAGAAGGCTCCCAGCCGACTCCCACTGCCTCCCAGCTTCCACATCCGCCCCGCCTCCCAGGTCTACCCAGACAGGGCCCCCGAG CCAGACTGCCCTGGGGAGCTCAAGGCCACAGCACCAGCCAGCCCAAGGCTTGGCCAGTCCCAGTCCCAAGCAGATGAACGAGCTGGGACT CCGCCTCCAGCCCCTCCCCTGCCCCCTCCTGCACCCCCCCTCCCTCCCCCAGCACCCCCACTTCCCCCAGCTGCACCTCCTTTGCCCTGT GCTCAGAAGGCAGCCCATCCACCTGCTGGGTTTACAAAAACCCCTAAATCCAGCTCTCCTGCTCTCAAACCCAAACCCAACCCCCCCAGC CCAGAGAACACAGCGTCTTCAGCACCTGTGGACTGGAGGGACCCCAGCCAGATGGAAAAGCTGCGGAACGAGCTGGCAGCCTATCTCTGT GGCTCCAGGAGAGAGGACCGATTCCTCAGTCACAGGCCAGGCCCAACAGTGGCCCCTCAGAGCAAGGAGGGCAAGAAGGGCCCCCGCCTG CCTGAGAAGGAGACTCTCCTGAGCCTGCCAGCAAAGGACACTCCCCCAGGTGTTCCTGAAAAGAGTCTTGGCGGCAGCAGCCTGACAGAG ACAGAGGCTGCCCCCAGCCTGACCCTGCCCTCTGTGGACTACATTCCCCAAGACTCTCCAACTCCCAGTGTGCGGCAGATCCGGAATGAG CTGGAGGCCCGGCTCTCCTCAGCAGCAGAGAAGGAGGCTAAGCCCAGCATAGGATCTCTGCCCCCTAAGCCTCGGCTAGAAGGGGGAAGA ATTTGTGAAAACGGGGCTGATGATGACAAACTCTCCAAGCCTGTGGCCAAGAATCTGCCACCTCAATCCACCACCCTGCTGCCAACTACA TCACTCCAGCCCAAGGCTATGTTGGGACCAGCCATACCACCCAAGGCCACACCTGAGCCAGCCATACCACCCAAGGCTACACTTTGGCCA GCCACACCACCCAAGGCCACACTTGGGCCAGCCACACCACTCAAGGCCACATCTGGGCCAACCACACCACTCAAGGCCACATCTGGCCCT GCCATAGCATCTACAGCCACAACTCTGCCCACCACCACATCCCAACTGATGGCAGAGAAGGACTCAGGCCCAGCTGGCCAGCCAGAGAAG CCAGCATCTCAAGAAGTTTCCACTCCCTCCCAGGCAAGGGGAGAGGGGTCCCCCTCAGAGGCCACTAGGCTGCCCACACAGGGAGCCCGC TCATCTGCAGCCTTCCCACCAAAGACATCTCCTGGTGGAGGAGAGGTGCCATGTCTCTACAAGCCCCACTGCCACCAGAGCAGCCTCAGC CGTGAGGTTGCTGTGGTGATGCCCACCCTGGCCAGAGGAGGGGCTGCAGGGCCAGGGGAGCCCGTGGAGGTGAAGGAGCCCCCAGGGCTG CCAGCCAAGCCTCCTGCCTCGGCCCAGCCCACTGATGAACTCCTCAGGCACCCGGTGACTGGGGAGGTGGTGGAGCGGGGCTCGCCGATG GCCCTGCTCCTGGCGGCCAGGCAGAGGGCTCAGAAGGGAAGGTCTGTAGGGGCTGCCCTGGGTCGGTCCTCTCTGCCAGGAAGTCTCCGT GACCACAGCCACCAAGCCGAGGCCAGCTCTGACAGCATCTTCCACAGCCAGGGCACGCCCAACTCCTTCACTGTGGTGCCCAAGTTACCC AAGGAGGCTGAGAAGGACTCCCCGCTGACGACCGAAATACCCAATAAGTGGGGGCCGCGGCTGGGAAGAGACGCAGAGGGCACAGAGCTG AGCCGCAGGCACAACTGGACAAAGCCAGAGCCCCAGGCCCCTGTGGCCTGGGAAAGAGTAGCTCCCTCCAACCTCCCCCAGGGCCACCCG CTGCCCAAGTCCTTCTCCTCCCCACCTTCTCCTTCGAACAAGAGGGAGGAGGAGGAGGAGGAGTTCAACTTCGAGGTCATCCCACCGCCG CCAGAGTTCAGCAATGACCCTGAGCCCCCGGCCCCGGCCCTCCAGTATCTGGGCCGCCAGAGCTCCCCTCCCCGGAACAACTACTCAGAC TTGAGGCAGCTCCCGAACGCTGGCCCCGGGGCGCCCCCGGCTCTCGGCTTCTCGCGCTTTCCCGCGGGCGCGCGCTACGCCGGGGCTGGG GGCCTGGAGCGCTTCTCGGGAGGGGGCCGCTCGCTCATAAAGAAGCGCCTGTACGTCGGGGAGCCGCACCGAGGCCCAGGGCTACCCCAC GGTGGCACCGGCCGCAGCCTGAGCTCTCCCAACTGCTTCGGGCCGCAGCCCGGAGGCCCCGAGATGCGGCGCGTGAACTCGGCGGGTCGC GCGCCCCCCGGAGGCCTGCACGCGCCGAGGCTGTCCCTGGAGGGCGCCGCCCGGGGCGCCGCGGAGGCCAAGCACAAAGCGCCCGGCAGC GCCGACTACGGCTTCGCCCCAGCTGCCGGCAGGTCTCCCTACACCACCACCCGCTATGGAAGCCCCATCAACACGTTCACCGTGAGGCCT GGGACCCGCCATCCCATCTCCTATGTCTGCTCAGGGGCCCATCGGAAAGCCACCTCCTGAGCCAGGGGTTCTCTTAGCTCTACTCCAACA AACTGTGTCTTTAAGGATCTGGGCACTTGTTTCTTGTGGGGGGTGGGAGGTACACAGCAGGTGTTGGGCGACCTGACTCAGACACAGAGG AGTCTTTGATCCCCAAAGACCAACGATGAGAAGCAGTGGCCCAGGAAGACCGAGAGTGGGCTTCTGTTTCCCAAAGCGCTGGTGTGACTG TGGACTGTTTACACGTGGGGGGTGGGAGGGGAAGGAGGGTAGAGAGAAGGAACCATTAAGGACCTGGGCGCTGAGTTTCTGCTCTCTGGT ACTATCTGCTTTAGCAAGAGTTATTTAAAACAGTTTTACAAGCACGGCCTACTGAGCAGGTTCTGAAAGCAAGGGGTGGGGCACTGACTG AACTGGAACCCATCGAGATAGCTGTGATTGCCTGTCAGGCCCTTGCAAAGGGCTGAGGCCCAGCTCTGTCTGGTGGGTGTGCAGGGCACC GAAGGGAGATCTTTAGCCTCCATCACCTGCCATCCCAAGCAAGAGTGGACACCTGGGGTTCCTAGCCGCATTGAGGTGGGACCAGGAATG TGTATGTATAACATGTGGAGAAGGACCATGTGTGGGGTGGGGAGTGAAGCTCCCACATGTGGAATGGAAGCCCTTTGCATTGGCCAAGGG CAGAGGTGGGAGATTGATGGTTCATTTTTCCTTGGCCCTAGCCCTTAGCTACAGGGAGGCCTAGAGAGAGGACACTTGGCAAGTTTAGGA TGGGAAACAAGGTTAAGCCTGGCTTTGCTATTCAGACCTGTGCAGCCCTGATTTTGGGGACTGGGCCCAAGGAGCCATGAGTCTTAGGCT TGACACTAGGGGCCTTACATGGCCAGGTCTCATATGGGATTTGGAGAAGGCATTTTTCCTAACACTGATACTACAAGTCACCAATACTCT TGATGCCTTAAGATGCTAGAAAGCCTTGGAGAGTGGAGGCAGCAGAGATGGGAATGGAGGTCTGAAGAAGCTTGCTGCTGTTGGGGAATG TGTTTGGGAAAGTCAAGAGTGGTAGGATTGGTTGGCTGGGCGCGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCCGGT GGATCACTTGAGGTCAGAAGTTCGAGACCAGCCTGCCCAAATGGTGAAACCCCATCTCTACTAAAAATACGGAAAAAAAAAAAAAAAGAG TGCTAGGATTGGGCCAGTTAAGAGCAGGGGAGACCTGGCTGGGCATGGTGGCTCACACCTGTAATTCTAGCACTTTGGGAGGCTGAGGCG GGTGGATCATGAGGTCAAGAGATTAAGACCATCCTGGCCTACATGGCGAAACCCTGTCTCTACTAAAAATAAAAAAATGACCTGGGCATG GTGGTGGGCGCCTGTAGTCCCAGCTACTCGGGGCGCTGAGGCAGGAGAATCGCTCGAACCCAGGAGGTGGAGGTTGCAGTGAGCCGAGAT TGCACAATTGCACTCCAGCCTGGCGACAGAGCGAGACTCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAGGAGCAGGGGAGACCTATCAG TAGGGTGACCACGTGTCCTTTGCCTGGGCAGTCCAGGTTTATGCTTGTTTTCCAGTGAATTAGACCCCCTTCCACTTTTCAAAAAAGTCC TGGTTTAGATGCTGTGATCACCAAACATATCAGGAAACAATATTCCTTGGTCTTGCTTCCCTATCTTCAGGTACTGGTGGGCCAAATTCC TGGGACCAGGTCAAGGTGGGCTGCCTCAGTAAGAAGGAAGGACTGGAGAGTGCCCATTTCAGAGGAGCAGGCTGGTGGGGGCCAGCCAGA AAGTAGTTCCCTTTGGGGGGAAGATGTTGGACCTTTATTATTTGTGGTAACCAGCCGAGGCTGGTTGTCAGGACAGCAGGTGAGCCACTT TAGGGAAGAAAGTGCAGGGGTGGGTGGATGCCCAGATTACCAAGGCCAGCCACCCTGATGGGGTAGGGTCTGGTTATCTGTGTTCAAGAA GCAAATCCCACCCCAGCCCCAGCACTAGCTCTCTATGTATGTATTTTCCCTGTACAATGTTTTATAAAAGAGATCATTAATTTATCTGCT ATGTTAAGGCTCGAGGGGTGGGGCGTAGACTCTCAGCTGTATATTGCTCTGGGGTGGGCAGGGAAGGCTGAGTCTCACTTGACTTGGAAG ATAAACAGGCCAGTTTGGACTGGCCTCCAGCTCCGTGGCTGTGTTTGTCTAACAAGGATTTGGGTAACTACTGGATACAAGCCACTGTGC TTAGTATGGATAGACTGCCATCAGCTCACCCACATGACTCCTGTTCATGGCAAGCTAATAGTCTGTCTGGTGGAAGAGGATTGAAAAAGC ACACAAAAACATCATAAATTACAAGGAGTAGTAAGAAGGAAAAAACAGGGAACGTGAGAGAATAACTAGCGAGTGGGGAGAGGAGTGGAT TTACTTTAACAGGGTAGTCAGGGAAGGCCTCTTGTGGTGGTGACATACTGATTTAGGCAAAGCGTCCAGCACGTGCCTAGCGCTTAGTAG TTGCTCAGCAAATGGCATCTTTGGGTGATGAATACCTCACATTTGTATATGGCCTGTCACAGTTTTCCATAAAGCTTTTTTTTTTAAGGC >In-frame_ENST00000307998_ENST00000341865_TCGA-BR-8590-01A_EFEMP2_chr11_65637328_-_C6orf132_chr6_42096516_length(amino acids)=1422AA_start in transcript=111_stop in transcript=4379 MGPRVQGAVPSARPSARRHCPSQPSRQSRGPRGCRGPNPRMLPCASCLPGSLLLWALLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQ HCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDC HNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQ GYELHRDGFSCSDGIYYGDNRFNTVSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLRLYSSVG DLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIP PAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPP PTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPL PPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDR FLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSS AAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKAT LGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPP KTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAAR QRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWT KPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDLRQLPNA GPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHGGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLH -------------------------------------------------------------- >In-frame_ENST00000307998_ENST00000356542_TCGA-BR-8590-01A_EFEMP2_chr11_65637328_-_C6orf132_chr6_42096516_length(transcript)=1532nt_BP=958nt GCGGGGGGTCGGGGTCCCTCCCCCTGGCGCTGGCTCAGGAATCCGCCGAAGGGCGGGCGGAGGCGCCGGGGTGGGCCGCGCCGCGGCAGG CGGGCGGGCGGGGGGCGCTTCCTGGGGCCGCGCGTCCAGGGAGCTGTGCCGTCCGCCCGTCCGTCTGCCCGCAGGCATTGCCCGAGCCAG CCGAGCCGCCAGAGCCGCGGGCCGCGGGGGTGTCGCGGGCCCAACCCCAGGATGCTCCCCTGCGCCTCCTGCCTACCCGGGTCTCTACTG CTCTGGGCGCTGCTACTGTTGCTCTTGGGATCAGCTTCTCCTCAGGATTCTGAAGAGCCCGACAGCTACACGGAATGCACAGATGGCTAT GAGTGGGACCCAGACAGCCAGCACTGCCGGGATGTCAACGAGTGTCTGACCATCCCTGAGGCCTGCAAGGGGGAAATGAAGTGCATCAAC CACTACGGGGGCTACTTGTGCCTGCCCCGCTCCGCTGCCGTCATCAACGACCTACACGGCGAGGGACCCCCGCCACCAGTGCCTCCCGCT CAACACCCCAACCCCTGCCCACCAGGCTATGAGCCCGACGATCAGGACAGCTGTGTGGATGTGGACGAGTGTGCCCAGGCCCTGCACGAC TGTCGCCCCAGCCAGGACTGCCATAACTTGCCTGGCTCCTATCAGTGCACCTGCCCTGATGGTTACCGCAAGATCGGGCCCGAGTGTGTG GACATAGACGAGTGCCGCTACCGCTACTGCCAGCACCGCTGCGTGAACCTGCCTGGCTCCTTCCGCTGCCAGTGCGAGCCGGGCTTCCAG CTGGGGCCTAACAACCGCTCCTGTGTTGATGTGAACGAGTGTGACATGGGGGCCCCATGCGAGCAGCGCTGCTTCAACTCCTATGGGACC TTCCTGTGTCGCTGCCACCAGGGCTATGAGCTGCATCGGGATGGCTTCTCCTGCAGTGATGGCATCTATTATGGAGACAATCGGTTTAAC ACAGTGAGCGAGTCAGGAACAGCCACGCTGAAAGCTCGGCCAAGAGTCCGGCCCCTGCTGACCTTCCTTCCGCTGACTGAGTTTCATTCT TGTTGCCCAGGCTGGAGTGGTACAATGGCGTGATCTCGGCTCCCTGCAACCTCCACCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCT CCCAAGTAGCTGGGATTACAGGTGCCCACCACCATGCCCGGCAAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATTTTGGCCAG GCTGGTCTCGAACTCCTGACCTCAGGTGATCCACAAACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCTACCGCGCCCAGCCT GAAATACTCTATATTGGGAGGTTAATTAGATTCTCTCCTATCACTTACCCTCAGCACACATACCCAGATTCATAGCAGTGTGGGCCCAGA GTTGACACACCTCTACCAGTCGGTAAAATACTAAAACATTCATCTGTAAAATGGGAATAAAAAAAAAAAAACAAATAAAATACTGAAATA >In-frame_ENST00000307998_ENST00000356542_TCGA-BR-8590-01A_EFEMP2_chr11_65637328_-_C6orf132_chr6_42096516_length(amino acids)=333AA_start in transcript=111_stop in transcript=1112 MGPRVQGAVPSARPSARRHCPSQPSRQSRGPRGCRGPNPRMLPCASCLPGSLLLWALLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQ HCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDC HNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQ -------------------------------------------------------------- >In-frame_ENST00000528176_ENST00000341865_TCGA-BR-8590_EFEMP2_chr11_65637327_-_C6orf132_chr6_42096516_length(transcript)=6860nt_BP=795nt GGCATTGCCCGAGCCAGCCGAGCCGCCAGAGCCGCGGGCCGCGGGGGTGTCGCGGGCCCAACCCCAGGATGCTCCCCTGCGCCTCCTGCC TACCCGGGTCTCTACTGCTCTGGGCGCTGCTACTGTTGCTCTTGGGATCAGCTTCTCCTCAGGATTCTGAAGAGCCCGACAGCTACACGG AATGCACAGATGGCTATGAGTGGGACCCAGACAGCCAGCACTGCCGGGATGTCAACGAGTGTCTGACCATCCCTGAGGCCTGCAAGGGGG AAATGAAGTGCATCAACCACTACGGGGGCTACTTGTGCCTGCCCCGCTCCGCTGCCGTCATCAACGACCTACACGGCGAGGGACCCCCGC CACCAGTGCCTCCCGCTCAACACCCCAACCCCTGCCCACCAGGCTATGAGCCCGACGATCAGGACAGCTGTGTGGATGTGGACGAGTGTG CCCAGGCCCTGCACGACTGTCGCCCCAGCCAGGACTGCCATAACTTGCCTGGCTCCTATCAGTGCACCTGCCCTGATGGTTACCGCAAGA TCGGGCCCGAGTGTGTGGACATAGACGAGTGCCGCTACCGCTACTGCCAGCACCGCTGCGTGAACCTGCCTGGCTCCTTCCGCTGCCAGT GCGAGCCGGGCTTCCAGCTGGGGCCTAACAACCGCTCCTGTGTTGATGTGAACGAGTGTGACATGGGGGCCCCATGCGAGCAGCGCTGCT TCAACTCCTATGGGACCTTCCTGTGTCGCTGCCACCAGGGCTATGAGCTGCATCGGGATGGCTTCTCCTGCAGTGATGGCATCTATTATG GAGACAATCGGTTTAACACAGTGAGCGAGTCAGGAACAGCCACGCTGAAAGCTCGGCCAAGAGTCCGGCCCCTGCTGACCTTCCTTCCGC TGAATGCCCAGGAAAACCATGGGCTGGCTGTGCCCACCCCCTCGGTTCCAGATGATTTTGCAGACAAAGAAGTGACAGGTACCAGCTCAC TAGTCAATGGCAACCTCCGACTGTACAGCTCTGTGGGTGACCTGAGGCCTGGACAATATGGCCAGGATCTACTCATCCCCCCACCTCCCC CAGGCCCAGCCCCAGGGCCCCCTCAGGACATTTCAGAACCTCCAGGGGGGTCGCCACTGCCATCTCCACCTTCCACAGCACCCCCACCAC CTCCCCTGCTGCTGGAACCCCCACCCCCGCCCAGCATGGCCCCACCTCCACCCCCAGTATTGGAGGCCCTATCCCCACCACACACTCTTT CCTCCCCATCCATACCCACCCCTCCTGACTTCATTCCCCCTGCCCCACCCTTGGCCTTTCTAGCCCCCCCACCGCCTCCTGTGCCAGCCC CAGCACCCCCAGCTCCAGCATCTCCTCACACAGTGGGGACTCGTCTCTTTCCCCCTGGGGGTGTCACCAAGTGGAAATCAGATGTAGCAC TGAATGGCAGGCAGGCAGAGGCCACCAGAGCCAGCCCCCCGAGAAGCCCTGCTGAGCCAAAGGGGAGCGCCCTGGGACCTAACCCAGAGC CCCATCTCACCTTCCCCCGTTCTTTCAAAGTGCCTCCCCCAACCCCAGTCAGGACTTCGTCCATCCCAGTTCAGGAAGCACAAGAGGCTC CCCGAAAGGAAGAGGGGGCCACCAAGAAGGCTCCCAGCCGACTCCCACTGCCTCCCAGCTTCCACATCCGCCCCGCCTCCCAGGTCTACC CAGACAGGGCCCCCGAGCCAGACTGCCCTGGGGAGCTCAAGGCCACAGCACCAGCCAGCCCAAGGCTTGGCCAGTCCCAGTCCCAAGCAG ATGAACGAGCTGGGACTCCGCCTCCAGCCCCTCCCCTGCCCCCTCCTGCACCCCCCCTCCCTCCCCCAGCACCCCCACTTCCCCCAGCTG CACCTCCTTTGCCCTGTGCTCAGAAGGCAGCCCATCCACCTGCTGGGTTTACAAAAACCCCTAAATCCAGCTCTCCTGCTCTCAAACCCA AACCCAACCCCCCCAGCCCAGAGAACACAGCGTCTTCAGCACCTGTGGACTGGAGGGACCCCAGCCAGATGGAAAAGCTGCGGAACGAGC TGGCAGCCTATCTCTGTGGCTCCAGGAGAGAGGACCGATTCCTCAGTCACAGGCCAGGCCCAACAGTGGCCCCTCAGAGCAAGGAGGGCA AGAAGGGCCCCCGCCTGCCTGAGAAGGAGACTCTCCTGAGCCTGCCAGCAAAGGACACTCCCCCAGGTGTTCCTGAAAAGAGTCTTGGCG GCAGCAGCCTGACAGAGACAGAGGCTGCCCCCAGCCTGACCCTGCCCTCTGTGGACTACATTCCCCAAGACTCTCCAACTCCCAGTGTGC GGCAGATCCGGAATGAGCTGGAGGCCCGGCTCTCCTCAGCAGCAGAGAAGGAGGCTAAGCCCAGCATAGGATCTCTGCCCCCTAAGCCTC GGCTAGAAGGGGGAAGAATTTGTGAAAACGGGGCTGATGATGACAAACTCTCCAAGCCTGTGGCCAAGAATCTGCCACCTCAATCCACCA CCCTGCTGCCAACTACATCACTCCAGCCCAAGGCTATGTTGGGACCAGCCATACCACCCAAGGCCACACCTGAGCCAGCCATACCACCCA AGGCTACACTTTGGCCAGCCACACCACCCAAGGCCACACTTGGGCCAGCCACACCACTCAAGGCCACATCTGGGCCAACCACACCACTCA AGGCCACATCTGGCCCTGCCATAGCATCTACAGCCACAACTCTGCCCACCACCACATCCCAACTGATGGCAGAGAAGGACTCAGGCCCAG CTGGCCAGCCAGAGAAGCCAGCATCTCAAGAAGTTTCCACTCCCTCCCAGGCAAGGGGAGAGGGGTCCCCCTCAGAGGCCACTAGGCTGC CCACACAGGGAGCCCGCTCATCTGCAGCCTTCCCACCAAAGACATCTCCTGGTGGAGGAGAGGTGCCATGTCTCTACAAGCCCCACTGCC ACCAGAGCAGCCTCAGCCGTGAGGTTGCTGTGGTGATGCCCACCCTGGCCAGAGGAGGGGCTGCAGGGCCAGGGGAGCCCGTGGAGGTGA AGGAGCCCCCAGGGCTGCCAGCCAAGCCTCCTGCCTCGGCCCAGCCCACTGATGAACTCCTCAGGCACCCGGTGACTGGGGAGGTGGTGG AGCGGGGCTCGCCGATGGCCCTGCTCCTGGCGGCCAGGCAGAGGGCTCAGAAGGGAAGGTCTGTAGGGGCTGCCCTGGGTCGGTCCTCTC TGCCAGGAAGTCTCCGTGACCACAGCCACCAAGCCGAGGCCAGCTCTGACAGCATCTTCCACAGCCAGGGCACGCCCAACTCCTTCACTG TGGTGCCCAAGTTACCCAAGGAGGCTGAGAAGGACTCCCCGCTGACGACCGAAATACCCAATAAGTGGGGGCCGCGGCTGGGAAGAGACG CAGAGGGCACAGAGCTGAGCCGCAGGCACAACTGGACAAAGCCAGAGCCCCAGGCCCCTGTGGCCTGGGAAAGAGTAGCTCCCTCCAACC TCCCCCAGGGCCACCCGCTGCCCAAGTCCTTCTCCTCCCCACCTTCTCCTTCGAACAAGAGGGAGGAGGAGGAGGAGGAGTTCAACTTCG AGGTCATCCCACCGCCGCCAGAGTTCAGCAATGACCCTGAGCCCCCGGCCCCGGCCCTCCAGTATCTGGGCCGCCAGAGCTCCCCTCCCC GGAACAACTACTCAGACTTGAGGCAGCTCCCGAACGCTGGCCCCGGGGCGCCCCCGGCTCTCGGCTTCTCGCGCTTTCCCGCGGGCGCGC GCTACGCCGGGGCTGGGGGCCTGGAGCGCTTCTCGGGAGGGGGCCGCTCGCTCATAAAGAAGCGCCTGTACGTCGGGGAGCCGCACCGAG GCCCAGGGCTACCCCACGGTGGCACCGGCCGCAGCCTGAGCTCTCCCAACTGCTTCGGGCCGCAGCCCGGAGGCCCCGAGATGCGGCGCG TGAACTCGGCGGGTCGCGCGCCCCCCGGAGGCCTGCACGCGCCGAGGCTGTCCCTGGAGGGCGCCGCCCGGGGCGCCGCGGAGGCCAAGC ACAAAGCGCCCGGCAGCGCCGACTACGGCTTCGCCCCAGCTGCCGGCAGGTCTCCCTACACCACCACCCGCTATGGAAGCCCCATCAACA CGTTCACCGTGAGGCCTGGGACCCGCCATCCCATCTCCTATGTCTGCTCAGGGGCCCATCGGAAAGCCACCTCCTGAGCCAGGGGTTCTC TTAGCTCTACTCCAACAAACTGTGTCTTTAAGGATCTGGGCACTTGTTTCTTGTGGGGGGTGGGAGGTACACAGCAGGTGTTGGGCGACC TGACTCAGACACAGAGGAGTCTTTGATCCCCAAAGACCAACGATGAGAAGCAGTGGCCCAGGAAGACCGAGAGTGGGCTTCTGTTTCCCA AAGCGCTGGTGTGACTGTGGACTGTTTACACGTGGGGGGTGGGAGGGGAAGGAGGGTAGAGAGAAGGAACCATTAAGGACCTGGGCGCTG AGTTTCTGCTCTCTGGTACTATCTGCTTTAGCAAGAGTTATTTAAAACAGTTTTACAAGCACGGCCTACTGAGCAGGTTCTGAAAGCAAG GGGTGGGGCACTGACTGAACTGGAACCCATCGAGATAGCTGTGATTGCCTGTCAGGCCCTTGCAAAGGGCTGAGGCCCAGCTCTGTCTGG TGGGTGTGCAGGGCACCGAAGGGAGATCTTTAGCCTCCATCACCTGCCATCCCAAGCAAGAGTGGACACCTGGGGTTCCTAGCCGCATTG AGGTGGGACCAGGAATGTGTATGTATAACATGTGGAGAAGGACCATGTGTGGGGTGGGGAGTGAAGCTCCCACATGTGGAATGGAAGCCC TTTGCATTGGCCAAGGGCAGAGGTGGGAGATTGATGGTTCATTTTTCCTTGGCCCTAGCCCTTAGCTACAGGGAGGCCTAGAGAGAGGAC ACTTGGCAAGTTTAGGATGGGAAACAAGGTTAAGCCTGGCTTTGCTATTCAGACCTGTGCAGCCCTGATTTTGGGGACTGGGCCCAAGGA GCCATGAGTCTTAGGCTTGACACTAGGGGCCTTACATGGCCAGGTCTCATATGGGATTTGGAGAAGGCATTTTTCCTAACACTGATACTA CAAGTCACCAATACTCTTGATGCCTTAAGATGCTAGAAAGCCTTGGAGAGTGGAGGCAGCAGAGATGGGAATGGAGGTCTGAAGAAGCTT GCTGCTGTTGGGGAATGTGTTTGGGAAAGTCAAGAGTGGTAGGATTGGTTGGCTGGGCGCGGTGGCTCACACCTGTAATCCCAGCACTTT GGGAGGCCGAGGCCGGTGGATCACTTGAGGTCAGAAGTTCGAGACCAGCCTGCCCAAATGGTGAAACCCCATCTCTACTAAAAATACGGA AAAAAAAAAAAAAAGAGTGCTAGGATTGGGCCAGTTAAGAGCAGGGGAGACCTGGCTGGGCATGGTGGCTCACACCTGTAATTCTAGCAC TTTGGGAGGCTGAGGCGGGTGGATCATGAGGTCAAGAGATTAAGACCATCCTGGCCTACATGGCGAAACCCTGTCTCTACTAAAAATAAA AAAATGACCTGGGCATGGTGGTGGGCGCCTGTAGTCCCAGCTACTCGGGGCGCTGAGGCAGGAGAATCGCTCGAACCCAGGAGGTGGAGG TTGCAGTGAGCCGAGATTGCACAATTGCACTCCAGCCTGGCGACAGAGCGAGACTCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAGGAG CAGGGGAGACCTATCAGTAGGGTGACCACGTGTCCTTTGCCTGGGCAGTCCAGGTTTATGCTTGTTTTCCAGTGAATTAGACCCCCTTCC ACTTTTCAAAAAAGTCCTGGTTTAGATGCTGTGATCACCAAACATATCAGGAAACAATATTCCTTGGTCTTGCTTCCCTATCTTCAGGTA CTGGTGGGCCAAATTCCTGGGACCAGGTCAAGGTGGGCTGCCTCAGTAAGAAGGAAGGACTGGAGAGTGCCCATTTCAGAGGAGCAGGCT GGTGGGGGCCAGCCAGAAAGTAGTTCCCTTTGGGGGGAAGATGTTGGACCTTTATTATTTGTGGTAACCAGCCGAGGCTGGTTGTCAGGA CAGCAGGTGAGCCACTTTAGGGAAGAAAGTGCAGGGGTGGGTGGATGCCCAGATTACCAAGGCCAGCCACCCTGATGGGGTAGGGTCTGG TTATCTGTGTTCAAGAAGCAAATCCCACCCCAGCCCCAGCACTAGCTCTCTATGTATGTATTTTCCCTGTACAATGTTTTATAAAAGAGA TCATTAATTTATCTGCTATGTTAAGGCTCGAGGGGTGGGGCGTAGACTCTCAGCTGTATATTGCTCTGGGGTGGGCAGGGAAGGCTGAGT CTCACTTGACTTGGAAGATAAACAGGCCAGTTTGGACTGGCCTCCAGCTCCGTGGCTGTGTTTGTCTAACAAGGATTTGGGTAACTACTG GATACAAGCCACTGTGCTTAGTATGGATAGACTGCCATCAGCTCACCCACATGACTCCTGTTCATGGCAAGCTAATAGTCTGTCTGGTGG AAGAGGATTGAAAAAGCACACAAAAACATCATAAATTACAAGGAGTAGTAAGAAGGAAAAAACAGGGAACGTGAGAGAATAACTAGCGAG TGGGGAGAGGAGTGGATTTACTTTAACAGGGTAGTCAGGGAAGGCCTCTTGTGGTGGTGACATACTGATTTAGGCAAAGCGTCCAGCACG TGCCTAGCGCTTAGTAGTTGCTCAGCAAATGGCATCTTTGGGTGATGAATACCTCACATTTGTATATGGCCTGTCACAGTTTTCCATAAA >In-frame_ENST00000528176_ENST00000341865_TCGA-BR-8590_EFEMP2_chr11_65637327_-_C6orf132_chr6_42096516_length(amino acids)=1382AA_start in transcript=68_stop in transcript=4216 MLPCASCLPGSLLLWALLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVIND LHGEGPPPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNL PGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDGIYYGDNRFNTVSESGTATLKARPRVR PLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLRLYSSVGDLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSP PSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVT KWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHI RPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKS SSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPG VPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSSAAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAK NLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKATLGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLM AEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPPKTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAG PGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAARQRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQ GTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWTKPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREE EEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDLRQLPNAGPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRL YVGEPHRGPGLPHGGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLHAPRLSLEGAARGAAEAKHKAPGSADYGFAPAAGRSPYTTT -------------------------------------------------------------- >In-frame_ENST00000528176_ENST00000356542_TCGA-BR-8590_EFEMP2_chr11_65637327_-_C6orf132_chr6_42096516_length(transcript)=1369nt_BP=795nt GGCATTGCCCGAGCCAGCCGAGCCGCCAGAGCCGCGGGCCGCGGGGGTGTCGCGGGCCCAACCCCAGGATGCTCCCCTGCGCCTCCTGCC TACCCGGGTCTCTACTGCTCTGGGCGCTGCTACTGTTGCTCTTGGGATCAGCTTCTCCTCAGGATTCTGAAGAGCCCGACAGCTACACGG AATGCACAGATGGCTATGAGTGGGACCCAGACAGCCAGCACTGCCGGGATGTCAACGAGTGTCTGACCATCCCTGAGGCCTGCAAGGGGG AAATGAAGTGCATCAACCACTACGGGGGCTACTTGTGCCTGCCCCGCTCCGCTGCCGTCATCAACGACCTACACGGCGAGGGACCCCCGC CACCAGTGCCTCCCGCTCAACACCCCAACCCCTGCCCACCAGGCTATGAGCCCGACGATCAGGACAGCTGTGTGGATGTGGACGAGTGTG CCCAGGCCCTGCACGACTGTCGCCCCAGCCAGGACTGCCATAACTTGCCTGGCTCCTATCAGTGCACCTGCCCTGATGGTTACCGCAAGA TCGGGCCCGAGTGTGTGGACATAGACGAGTGCCGCTACCGCTACTGCCAGCACCGCTGCGTGAACCTGCCTGGCTCCTTCCGCTGCCAGT GCGAGCCGGGCTTCCAGCTGGGGCCTAACAACCGCTCCTGTGTTGATGTGAACGAGTGTGACATGGGGGCCCCATGCGAGCAGCGCTGCT TCAACTCCTATGGGACCTTCCTGTGTCGCTGCCACCAGGGCTATGAGCTGCATCGGGATGGCTTCTCCTGCAGTGATGGCATCTATTATG GAGACAATCGGTTTAACACAGTGAGCGAGTCAGGAACAGCCACGCTGAAAGCTCGGCCAAGAGTCCGGCCCCTGCTGACCTTCCTTCCGC TGACTGAGTTTCATTCTTGTTGCCCAGGCTGGAGTGGTACAATGGCGTGATCTCGGCTCCCTGCAACCTCCACCTCCTGGGTTCAAGCGA TTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTGCCCACCACCATGCCCGGCAAATTTTTTGTATTTTTAGTAGAGACAGGGT TTCACCATTTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACAAACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGA GCTACCGCGCCCAGCCTGAAATACTCTATATTGGGAGGTTAATTAGATTCTCTCCTATCACTTACCCTCAGCACACATACCCAGATTCAT AGCAGTGTGGGCCCAGAGTTGACACACCTCTACCAGTCGGTAAAATACTAAAACATTCATCTGTAAAATGGGAATAAAAAAAAAAAAACA >In-frame_ENST00000528176_ENST00000356542_TCGA-BR-8590_EFEMP2_chr11_65637327_-_C6orf132_chr6_42096516_length(amino acids)=293AA_start in transcript=68_stop in transcript=949 MLPCASCLPGSLLLWALLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVIND LHGEGPPPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNL PGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDGIYYGDNRFNTVSESGTATLKARPRVR -------------------------------------------------------------- >In-frame_ENST00000307998_ENST00000341865_TCGA-BR-8590_EFEMP2_chr11_65637327_-_C6orf132_chr6_42096516_length(transcript)=7023nt_BP=958nt GCGGGGGGTCGGGGTCCCTCCCCCTGGCGCTGGCTCAGGAATCCGCCGAAGGGCGGGCGGAGGCGCCGGGGTGGGCCGCGCCGCGGCAGG CGGGCGGGCGGGGGGCGCTTCCTGGGGCCGCGCGTCCAGGGAGCTGTGCCGTCCGCCCGTCCGTCTGCCCGCAGGCATTGCCCGAGCCAG CCGAGCCGCCAGAGCCGCGGGCCGCGGGGGTGTCGCGGGCCCAACCCCAGGATGCTCCCCTGCGCCTCCTGCCTACCCGGGTCTCTACTG CTCTGGGCGCTGCTACTGTTGCTCTTGGGATCAGCTTCTCCTCAGGATTCTGAAGAGCCCGACAGCTACACGGAATGCACAGATGGCTAT GAGTGGGACCCAGACAGCCAGCACTGCCGGGATGTCAACGAGTGTCTGACCATCCCTGAGGCCTGCAAGGGGGAAATGAAGTGCATCAAC CACTACGGGGGCTACTTGTGCCTGCCCCGCTCCGCTGCCGTCATCAACGACCTACACGGCGAGGGACCCCCGCCACCAGTGCCTCCCGCT CAACACCCCAACCCCTGCCCACCAGGCTATGAGCCCGACGATCAGGACAGCTGTGTGGATGTGGACGAGTGTGCCCAGGCCCTGCACGAC TGTCGCCCCAGCCAGGACTGCCATAACTTGCCTGGCTCCTATCAGTGCACCTGCCCTGATGGTTACCGCAAGATCGGGCCCGAGTGTGTG GACATAGACGAGTGCCGCTACCGCTACTGCCAGCACCGCTGCGTGAACCTGCCTGGCTCCTTCCGCTGCCAGTGCGAGCCGGGCTTCCAG CTGGGGCCTAACAACCGCTCCTGTGTTGATGTGAACGAGTGTGACATGGGGGCCCCATGCGAGCAGCGCTGCTTCAACTCCTATGGGACC TTCCTGTGTCGCTGCCACCAGGGCTATGAGCTGCATCGGGATGGCTTCTCCTGCAGTGATGGCATCTATTATGGAGACAATCGGTTTAAC ACAGTGAGCGAGTCAGGAACAGCCACGCTGAAAGCTCGGCCAAGAGTCCGGCCCCTGCTGACCTTCCTTCCGCTGAATGCCCAGGAAAAC CATGGGCTGGCTGTGCCCACCCCCTCGGTTCCAGATGATTTTGCAGACAAAGAAGTGACAGGTACCAGCTCACTAGTCAATGGCAACCTC CGACTGTACAGCTCTGTGGGTGACCTGAGGCCTGGACAATATGGCCAGGATCTACTCATCCCCCCACCTCCCCCAGGCCCAGCCCCAGGG CCCCCTCAGGACATTTCAGAACCTCCAGGGGGGTCGCCACTGCCATCTCCACCTTCCACAGCACCCCCACCACCTCCCCTGCTGCTGGAA CCCCCACCCCCGCCCAGCATGGCCCCACCTCCACCCCCAGTATTGGAGGCCCTATCCCCACCACACACTCTTTCCTCCCCATCCATACCC ACCCCTCCTGACTTCATTCCCCCTGCCCCACCCTTGGCCTTTCTAGCCCCCCCACCGCCTCCTGTGCCAGCCCCAGCACCCCCAGCTCCA GCATCTCCTCACACAGTGGGGACTCGTCTCTTTCCCCCTGGGGGTGTCACCAAGTGGAAATCAGATGTAGCACTGAATGGCAGGCAGGCA GAGGCCACCAGAGCCAGCCCCCCGAGAAGCCCTGCTGAGCCAAAGGGGAGCGCCCTGGGACCTAACCCAGAGCCCCATCTCACCTTCCCC CGTTCTTTCAAAGTGCCTCCCCCAACCCCAGTCAGGACTTCGTCCATCCCAGTTCAGGAAGCACAAGAGGCTCCCCGAAAGGAAGAGGGG GCCACCAAGAAGGCTCCCAGCCGACTCCCACTGCCTCCCAGCTTCCACATCCGCCCCGCCTCCCAGGTCTACCCAGACAGGGCCCCCGAG CCAGACTGCCCTGGGGAGCTCAAGGCCACAGCACCAGCCAGCCCAAGGCTTGGCCAGTCCCAGTCCCAAGCAGATGAACGAGCTGGGACT CCGCCTCCAGCCCCTCCCCTGCCCCCTCCTGCACCCCCCCTCCCTCCCCCAGCACCCCCACTTCCCCCAGCTGCACCTCCTTTGCCCTGT GCTCAGAAGGCAGCCCATCCACCTGCTGGGTTTACAAAAACCCCTAAATCCAGCTCTCCTGCTCTCAAACCCAAACCCAACCCCCCCAGC CCAGAGAACACAGCGTCTTCAGCACCTGTGGACTGGAGGGACCCCAGCCAGATGGAAAAGCTGCGGAACGAGCTGGCAGCCTATCTCTGT GGCTCCAGGAGAGAGGACCGATTCCTCAGTCACAGGCCAGGCCCAACAGTGGCCCCTCAGAGCAAGGAGGGCAAGAAGGGCCCCCGCCTG CCTGAGAAGGAGACTCTCCTGAGCCTGCCAGCAAAGGACACTCCCCCAGGTGTTCCTGAAAAGAGTCTTGGCGGCAGCAGCCTGACAGAG ACAGAGGCTGCCCCCAGCCTGACCCTGCCCTCTGTGGACTACATTCCCCAAGACTCTCCAACTCCCAGTGTGCGGCAGATCCGGAATGAG CTGGAGGCCCGGCTCTCCTCAGCAGCAGAGAAGGAGGCTAAGCCCAGCATAGGATCTCTGCCCCCTAAGCCTCGGCTAGAAGGGGGAAGA ATTTGTGAAAACGGGGCTGATGATGACAAACTCTCCAAGCCTGTGGCCAAGAATCTGCCACCTCAATCCACCACCCTGCTGCCAACTACA TCACTCCAGCCCAAGGCTATGTTGGGACCAGCCATACCACCCAAGGCCACACCTGAGCCAGCCATACCACCCAAGGCTACACTTTGGCCA GCCACACCACCCAAGGCCACACTTGGGCCAGCCACACCACTCAAGGCCACATCTGGGCCAACCACACCACTCAAGGCCACATCTGGCCCT GCCATAGCATCTACAGCCACAACTCTGCCCACCACCACATCCCAACTGATGGCAGAGAAGGACTCAGGCCCAGCTGGCCAGCCAGAGAAG CCAGCATCTCAAGAAGTTTCCACTCCCTCCCAGGCAAGGGGAGAGGGGTCCCCCTCAGAGGCCACTAGGCTGCCCACACAGGGAGCCCGC TCATCTGCAGCCTTCCCACCAAAGACATCTCCTGGTGGAGGAGAGGTGCCATGTCTCTACAAGCCCCACTGCCACCAGAGCAGCCTCAGC CGTGAGGTTGCTGTGGTGATGCCCACCCTGGCCAGAGGAGGGGCTGCAGGGCCAGGGGAGCCCGTGGAGGTGAAGGAGCCCCCAGGGCTG CCAGCCAAGCCTCCTGCCTCGGCCCAGCCCACTGATGAACTCCTCAGGCACCCGGTGACTGGGGAGGTGGTGGAGCGGGGCTCGCCGATG GCCCTGCTCCTGGCGGCCAGGCAGAGGGCTCAGAAGGGAAGGTCTGTAGGGGCTGCCCTGGGTCGGTCCTCTCTGCCAGGAAGTCTCCGT GACCACAGCCACCAAGCCGAGGCCAGCTCTGACAGCATCTTCCACAGCCAGGGCACGCCCAACTCCTTCACTGTGGTGCCCAAGTTACCC AAGGAGGCTGAGAAGGACTCCCCGCTGACGACCGAAATACCCAATAAGTGGGGGCCGCGGCTGGGAAGAGACGCAGAGGGCACAGAGCTG AGCCGCAGGCACAACTGGACAAAGCCAGAGCCCCAGGCCCCTGTGGCCTGGGAAAGAGTAGCTCCCTCCAACCTCCCCCAGGGCCACCCG CTGCCCAAGTCCTTCTCCTCCCCACCTTCTCCTTCGAACAAGAGGGAGGAGGAGGAGGAGGAGTTCAACTTCGAGGTCATCCCACCGCCG CCAGAGTTCAGCAATGACCCTGAGCCCCCGGCCCCGGCCCTCCAGTATCTGGGCCGCCAGAGCTCCCCTCCCCGGAACAACTACTCAGAC TTGAGGCAGCTCCCGAACGCTGGCCCCGGGGCGCCCCCGGCTCTCGGCTTCTCGCGCTTTCCCGCGGGCGCGCGCTACGCCGGGGCTGGG GGCCTGGAGCGCTTCTCGGGAGGGGGCCGCTCGCTCATAAAGAAGCGCCTGTACGTCGGGGAGCCGCACCGAGGCCCAGGGCTACCCCAC GGTGGCACCGGCCGCAGCCTGAGCTCTCCCAACTGCTTCGGGCCGCAGCCCGGAGGCCCCGAGATGCGGCGCGTGAACTCGGCGGGTCGC GCGCCCCCCGGAGGCCTGCACGCGCCGAGGCTGTCCCTGGAGGGCGCCGCCCGGGGCGCCGCGGAGGCCAAGCACAAAGCGCCCGGCAGC GCCGACTACGGCTTCGCCCCAGCTGCCGGCAGGTCTCCCTACACCACCACCCGCTATGGAAGCCCCATCAACACGTTCACCGTGAGGCCT GGGACCCGCCATCCCATCTCCTATGTCTGCTCAGGGGCCCATCGGAAAGCCACCTCCTGAGCCAGGGGTTCTCTTAGCTCTACTCCAACA AACTGTGTCTTTAAGGATCTGGGCACTTGTTTCTTGTGGGGGGTGGGAGGTACACAGCAGGTGTTGGGCGACCTGACTCAGACACAGAGG AGTCTTTGATCCCCAAAGACCAACGATGAGAAGCAGTGGCCCAGGAAGACCGAGAGTGGGCTTCTGTTTCCCAAAGCGCTGGTGTGACTG TGGACTGTTTACACGTGGGGGGTGGGAGGGGAAGGAGGGTAGAGAGAAGGAACCATTAAGGACCTGGGCGCTGAGTTTCTGCTCTCTGGT ACTATCTGCTTTAGCAAGAGTTATTTAAAACAGTTTTACAAGCACGGCCTACTGAGCAGGTTCTGAAAGCAAGGGGTGGGGCACTGACTG AACTGGAACCCATCGAGATAGCTGTGATTGCCTGTCAGGCCCTTGCAAAGGGCTGAGGCCCAGCTCTGTCTGGTGGGTGTGCAGGGCACC GAAGGGAGATCTTTAGCCTCCATCACCTGCCATCCCAAGCAAGAGTGGACACCTGGGGTTCCTAGCCGCATTGAGGTGGGACCAGGAATG TGTATGTATAACATGTGGAGAAGGACCATGTGTGGGGTGGGGAGTGAAGCTCCCACATGTGGAATGGAAGCCCTTTGCATTGGCCAAGGG CAGAGGTGGGAGATTGATGGTTCATTTTTCCTTGGCCCTAGCCCTTAGCTACAGGGAGGCCTAGAGAGAGGACACTTGGCAAGTTTAGGA TGGGAAACAAGGTTAAGCCTGGCTTTGCTATTCAGACCTGTGCAGCCCTGATTTTGGGGACTGGGCCCAAGGAGCCATGAGTCTTAGGCT TGACACTAGGGGCCTTACATGGCCAGGTCTCATATGGGATTTGGAGAAGGCATTTTTCCTAACACTGATACTACAAGTCACCAATACTCT TGATGCCTTAAGATGCTAGAAAGCCTTGGAGAGTGGAGGCAGCAGAGATGGGAATGGAGGTCTGAAGAAGCTTGCTGCTGTTGGGGAATG TGTTTGGGAAAGTCAAGAGTGGTAGGATTGGTTGGCTGGGCGCGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCCGGT GGATCACTTGAGGTCAGAAGTTCGAGACCAGCCTGCCCAAATGGTGAAACCCCATCTCTACTAAAAATACGGAAAAAAAAAAAAAAAGAG TGCTAGGATTGGGCCAGTTAAGAGCAGGGGAGACCTGGCTGGGCATGGTGGCTCACACCTGTAATTCTAGCACTTTGGGAGGCTGAGGCG GGTGGATCATGAGGTCAAGAGATTAAGACCATCCTGGCCTACATGGCGAAACCCTGTCTCTACTAAAAATAAAAAAATGACCTGGGCATG GTGGTGGGCGCCTGTAGTCCCAGCTACTCGGGGCGCTGAGGCAGGAGAATCGCTCGAACCCAGGAGGTGGAGGTTGCAGTGAGCCGAGAT TGCACAATTGCACTCCAGCCTGGCGACAGAGCGAGACTCGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAGGAGCAGGGGAGACCTATCAG TAGGGTGACCACGTGTCCTTTGCCTGGGCAGTCCAGGTTTATGCTTGTTTTCCAGTGAATTAGACCCCCTTCCACTTTTCAAAAAAGTCC TGGTTTAGATGCTGTGATCACCAAACATATCAGGAAACAATATTCCTTGGTCTTGCTTCCCTATCTTCAGGTACTGGTGGGCCAAATTCC TGGGACCAGGTCAAGGTGGGCTGCCTCAGTAAGAAGGAAGGACTGGAGAGTGCCCATTTCAGAGGAGCAGGCTGGTGGGGGCCAGCCAGA AAGTAGTTCCCTTTGGGGGGAAGATGTTGGACCTTTATTATTTGTGGTAACCAGCCGAGGCTGGTTGTCAGGACAGCAGGTGAGCCACTT TAGGGAAGAAAGTGCAGGGGTGGGTGGATGCCCAGATTACCAAGGCCAGCCACCCTGATGGGGTAGGGTCTGGTTATCTGTGTTCAAGAA GCAAATCCCACCCCAGCCCCAGCACTAGCTCTCTATGTATGTATTTTCCCTGTACAATGTTTTATAAAAGAGATCATTAATTTATCTGCT ATGTTAAGGCTCGAGGGGTGGGGCGTAGACTCTCAGCTGTATATTGCTCTGGGGTGGGCAGGGAAGGCTGAGTCTCACTTGACTTGGAAG ATAAACAGGCCAGTTTGGACTGGCCTCCAGCTCCGTGGCTGTGTTTGTCTAACAAGGATTTGGGTAACTACTGGATACAAGCCACTGTGC TTAGTATGGATAGACTGCCATCAGCTCACCCACATGACTCCTGTTCATGGCAAGCTAATAGTCTGTCTGGTGGAAGAGGATTGAAAAAGC ACACAAAAACATCATAAATTACAAGGAGTAGTAAGAAGGAAAAAACAGGGAACGTGAGAGAATAACTAGCGAGTGGGGAGAGGAGTGGAT TTACTTTAACAGGGTAGTCAGGGAAGGCCTCTTGTGGTGGTGACATACTGATTTAGGCAAAGCGTCCAGCACGTGCCTAGCGCTTAGTAG TTGCTCAGCAAATGGCATCTTTGGGTGATGAATACCTCACATTTGTATATGGCCTGTCACAGTTTTCCATAAAGCTTTTTTTTTTAAGGC >In-frame_ENST00000307998_ENST00000341865_TCGA-BR-8590_EFEMP2_chr11_65637327_-_C6orf132_chr6_42096516_length(amino acids)=1422AA_start in transcript=111_stop in transcript=4379 MGPRVQGAVPSARPSARRHCPSQPSRQSRGPRGCRGPNPRMLPCASCLPGSLLLWALLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQ HCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDC HNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQ GYELHRDGFSCSDGIYYGDNRFNTVSESGTATLKARPRVRPLLTFLPLNAQENHGLAVPTPSVPDDFADKEVTGTSSLVNGNLRLYSSVG DLRPGQYGQDLLIPPPPPGPAPGPPQDISEPPGGSPLPSPPSTAPPPPPLLLEPPPPPSMAPPPPPVLEALSPPHTLSSPSIPTPPDFIP PAPPLAFLAPPPPPVPAPAPPAPASPHTVGTRLFPPGGVTKWKSDVALNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPP PTPVRTSSIPVQEAQEAPRKEEGATKKAPSRLPLPPSFHIRPASQVYPDRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPL PPPAPPLPPPAPPLPPAAPPLPCAQKAAHPPAGFTKTPKSSSPALKPKPNPPSPENTASSAPVDWRDPSQMEKLRNELAAYLCGSRREDR FLSHRPGPTVAPQSKEGKKGPRLPEKETLLSLPAKDTPPGVPEKSLGGSSLTETEAAPSLTLPSVDYIPQDSPTPSVRQIRNELEARLSS AAEKEAKPSIGSLPPKPRLEGGRICENGADDDKLSKPVAKNLPPQSTTLLPTTSLQPKAMLGPAIPPKATPEPAIPPKATLWPATPPKAT LGPATPLKATSGPTTPLKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTPSQARGEGSPSEATRLPTQGARSSAAFPP KTSPGGGEVPCLYKPHCHQSSLSREVAVVMPTLARGGAAGPGEPVEVKEPPGLPAKPPASAQPTDELLRHPVTGEVVERGSPMALLLAAR QRAQKGRSVGAALGRSSLPGSLRDHSHQAEASSDSIFHSQGTPNSFTVVPKLPKEAEKDSPLTTEIPNKWGPRLGRDAEGTELSRRHNWT KPEPQAPVAWERVAPSNLPQGHPLPKSFSSPPSPSNKREEEEEEFNFEVIPPPPEFSNDPEPPAPALQYLGRQSSPPRNNYSDLRQLPNA GPGAPPALGFSRFPAGARYAGAGGLERFSGGGRSLIKKRLYVGEPHRGPGLPHGGTGRSLSSPNCFGPQPGGPEMRRVNSAGRAPPGGLH -------------------------------------------------------------- >In-frame_ENST00000307998_ENST00000356542_TCGA-BR-8590_EFEMP2_chr11_65637327_-_C6orf132_chr6_42096516_length(transcript)=1532nt_BP=958nt GCGGGGGGTCGGGGTCCCTCCCCCTGGCGCTGGCTCAGGAATCCGCCGAAGGGCGGGCGGAGGCGCCGGGGTGGGCCGCGCCGCGGCAGG CGGGCGGGCGGGGGGCGCTTCCTGGGGCCGCGCGTCCAGGGAGCTGTGCCGTCCGCCCGTCCGTCTGCCCGCAGGCATTGCCCGAGCCAG CCGAGCCGCCAGAGCCGCGGGCCGCGGGGGTGTCGCGGGCCCAACCCCAGGATGCTCCCCTGCGCCTCCTGCCTACCCGGGTCTCTACTG CTCTGGGCGCTGCTACTGTTGCTCTTGGGATCAGCTTCTCCTCAGGATTCTGAAGAGCCCGACAGCTACACGGAATGCACAGATGGCTAT GAGTGGGACCCAGACAGCCAGCACTGCCGGGATGTCAACGAGTGTCTGACCATCCCTGAGGCCTGCAAGGGGGAAATGAAGTGCATCAAC CACTACGGGGGCTACTTGTGCCTGCCCCGCTCCGCTGCCGTCATCAACGACCTACACGGCGAGGGACCCCCGCCACCAGTGCCTCCCGCT CAACACCCCAACCCCTGCCCACCAGGCTATGAGCCCGACGATCAGGACAGCTGTGTGGATGTGGACGAGTGTGCCCAGGCCCTGCACGAC TGTCGCCCCAGCCAGGACTGCCATAACTTGCCTGGCTCCTATCAGTGCACCTGCCCTGATGGTTACCGCAAGATCGGGCCCGAGTGTGTG GACATAGACGAGTGCCGCTACCGCTACTGCCAGCACCGCTGCGTGAACCTGCCTGGCTCCTTCCGCTGCCAGTGCGAGCCGGGCTTCCAG CTGGGGCCTAACAACCGCTCCTGTGTTGATGTGAACGAGTGTGACATGGGGGCCCCATGCGAGCAGCGCTGCTTCAACTCCTATGGGACC TTCCTGTGTCGCTGCCACCAGGGCTATGAGCTGCATCGGGATGGCTTCTCCTGCAGTGATGGCATCTATTATGGAGACAATCGGTTTAAC ACAGTGAGCGAGTCAGGAACAGCCACGCTGAAAGCTCGGCCAAGAGTCCGGCCCCTGCTGACCTTCCTTCCGCTGACTGAGTTTCATTCT TGTTGCCCAGGCTGGAGTGGTACAATGGCGTGATCTCGGCTCCCTGCAACCTCCACCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCT CCCAAGTAGCTGGGATTACAGGTGCCCACCACCATGCCCGGCAAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATTTTGGCCAG GCTGGTCTCGAACTCCTGACCTCAGGTGATCCACAAACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCTACCGCGCCCAGCCT GAAATACTCTATATTGGGAGGTTAATTAGATTCTCTCCTATCACTTACCCTCAGCACACATACCCAGATTCATAGCAGTGTGGGCCCAGA GTTGACACACCTCTACCAGTCGGTAAAATACTAAAACATTCATCTGTAAAATGGGAATAAAAAAAAAAAAACAAATAAAATACTGAAATA >In-frame_ENST00000307998_ENST00000356542_TCGA-BR-8590_EFEMP2_chr11_65637327_-_C6orf132_chr6_42096516_length(amino acids)=333AA_start in transcript=111_stop in transcript=1112 MGPRVQGAVPSARPSARRHCPSQPSRQSRGPRGCRGPNPRMLPCASCLPGSLLLWALLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQ HCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDC HNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQ -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for EFEMP2-C6orf132 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for EFEMP2-C6orf132 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for EFEMP2-C6orf132 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | EFEMP2 | C4707243 | Familial thoracic aortic aneurysm and aortic dissection | 8 | CLINGEN;GENOMICS_ENGLAND |
| Hgene | EFEMP2 | C3280798 | CUTIS LAXA, AUTOSOMAL RECESSIVE, TYPE IB | 4 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| Hgene | EFEMP2 | C0003486 | Aortic Aneurysm | 2 | GENOMICS_ENGLAND |
| Hgene | EFEMP2 | C0268351 | Cutis Laxa, Autosomal Recessive, Type I | 2 | ORPHANET |
| Hgene | EFEMP2 | C0432336 | Cutis laxa, recessive, type I | 2 | ORPHANET |
| Hgene | EFEMP2 | C0010495 | Cutis Laxa | 1 | GENOMICS_ENGLAND |
| Hgene | EFEMP2 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | EFEMP2 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
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