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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EFTUD2-KRT24 (FusionGDB2 ID:25398)

Fusion Gene Summary for EFTUD2-KRT24

check button Fusion gene summary
Fusion gene informationFusion gene name: EFTUD2-KRT24
Fusion gene ID: 25398
HgeneTgene
Gene symbol

EFTUD2

KRT24

Gene ID

9343

192666

Gene nameelongation factor Tu GTP binding domain containing 2keratin 24
SynonymsMFDGA|MFDM|SNRNP116|Snrp116|Snu114|U5-116KDK24|KA24
Cytomap

17q21.31

17q21.2

Type of geneprotein-codingprotein-coding
Description116 kDa U5 small nuclear ribonucleoprotein componentSNU114 homologU5 snRNP-specific protein, 116 kDaelongation factor Tu GTP-binding domain-containing protein 2hSNU114keratin, type I cytoskeletal 24CK-24cytokeratin-24keratin 24, type Itype I keratin-24
Modification date2020031320200313
UniProtAcc

Q15029

.
Ensembl transtripts involved in fusion geneENST00000426333, ENST00000592576, 
ENST00000591382, ENST00000402521, 
ENST00000589211, 		ENST00000264651, 
Fusion gene scores* DoF score14 X 12 X 10=16804 X 1 X 3=12
# samples 154
** MAII scorelog2(15/1680*10)=-3.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/12*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: EFTUD2 [Title/Abstract] AND KRT24 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEFTUD2(42956924)-KRT24(38858185), # samples:2
Anticipated loss of major functional domain due to fusion event.EFTUD2-KRT24 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEFTUD2

GO:0000398

mRNA splicing, via spliceosome

28076346


check buttonFusion gene breakpoints across EFTUD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across KRT24 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CN-5370EFTUD2chr17

42956923

-KRT24chr17

38858185

-
ChimerDB4HNSCTCGA-CN-5370EFTUD2chr17

42956924

-KRT24chr17

38858185

-
ChimerDB4HNSCTCGA-CN-5370-01AEFTUD2chr17

42956924

-KRT24chr17

38858185

-


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Fusion Gene ORF analysis for EFTUD2-KRT24

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000426333ENST00000264651EFTUD2chr17

42956923

-KRT24chr17

38858185

-
Frame-shiftENST00000592576ENST00000264651EFTUD2chr17

42956923

-KRT24chr17

38858185

-
In-frameENST00000591382ENST00000264651EFTUD2chr17

42956923

-KRT24chr17

38858185

-
In-frameENST00000402521ENST00000264651EFTUD2chr17

42956923

-KRT24chr17

38858185

-
intron-3CDSENST00000589211ENST00000264651EFTUD2chr17

42956923

-KRT24chr17

38858185

-
Frame-shiftENST00000426333ENST00000264651EFTUD2chr17

42956924

-KRT24chr17

38858185

-
Frame-shiftENST00000592576ENST00000264651EFTUD2chr17

42956924

-KRT24chr17

38858185

-
In-frameENST00000591382ENST00000264651EFTUD2chr17

42956924

-KRT24chr17

38858185

-
In-frameENST00000402521ENST00000264651EFTUD2chr17

42956924

-KRT24chr17

38858185

-
intron-3CDSENST00000589211ENST00000264651EFTUD2chr17

42956924

-KRT24chr17

38858185

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000591382EFTUD2chr1742956923-ENST00000264651KRT24chr1738858185-230911003982062554
ENST00000402521EFTUD2chr1742956923-ENST00000264651KRT24chr1738858185-1883674621636524
ENST00000591382EFTUD2chr1742956924-ENST00000264651KRT24chr1738858185-230911003982062554
ENST00000402521EFTUD2chr1742956924-ENST00000264651KRT24chr1738858185-1883674621636524

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000591382ENST00000264651EFTUD2chr1742956923-KRT24chr1738858185-0.0017735760.99822646
ENST00000402521ENST00000264651EFTUD2chr1742956923-KRT24chr1738858185-0.0034666540.9965333
ENST00000591382ENST00000264651EFTUD2chr1742956924-KRT24chr1738858185-0.0017735760.99822646
ENST00000402521ENST00000264651EFTUD2chr1742956924-KRT24chr1738858185-0.0034666540.9965333

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Fusion Genomic Features for EFTUD2-KRT24


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EFTUD2-KRT24


check button Go to

FGviewer for the breakpoints of chr17:42956923-chr17:38858185

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EFTUD2

Q15029

.
FUNCTION: Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes (PubMed:28502770, PubMed:28781166, PubMed:28076346, PubMed:29361316, PubMed:30315277, PubMed:29360106, PubMed:29301961, PubMed:30705154). Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome (PubMed:16723661). {ECO:0000269|PubMed:16723661, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:30705154}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEFTUD2chr17:42956923chr17:38858185ENST00000402521-827136_143199.0938.0Nucleotide bindingGTP
HgeneEFTUD2chr17:42956923chr17:38858185ENST00000426333-928136_143234.0973.0Nucleotide bindingGTP
HgeneEFTUD2chr17:42956923chr17:38858185ENST00000426333-928204_208234.0973.0Nucleotide bindingGTP
HgeneEFTUD2chr17:42956923chr17:38858185ENST00000591382-928136_143234.0973.0Nucleotide bindingGTP
HgeneEFTUD2chr17:42956923chr17:38858185ENST00000591382-928204_208234.0973.0Nucleotide bindingGTP
HgeneEFTUD2chr17:42956924chr17:38858185ENST00000402521-827136_143199.0938.0Nucleotide bindingGTP
HgeneEFTUD2chr17:42956924chr17:38858185ENST00000426333-928136_143234.0973.0Nucleotide bindingGTP
HgeneEFTUD2chr17:42956924chr17:38858185ENST00000426333-928204_208234.0973.0Nucleotide bindingGTP
HgeneEFTUD2chr17:42956924chr17:38858185ENST00000591382-928136_143234.0973.0Nucleotide bindingGTP
HgeneEFTUD2chr17:42956924chr17:38858185ENST00000591382-928204_208234.0973.0Nucleotide bindingGTP
TgeneKRT24chr17:42956923chr17:38858185ENST0000026465108291_313205.0526.0RegionNote=Linker 12
TgeneKRT24chr17:42956923chr17:38858185ENST0000026465108314_452205.0526.0RegionNote=Coil 2
TgeneKRT24chr17:42956923chr17:38858185ENST0000026465108453_525205.0526.0RegionNote=Tail
TgeneKRT24chr17:42956924chr17:38858185ENST0000026465108291_313205.0526.0RegionNote=Linker 12
TgeneKRT24chr17:42956924chr17:38858185ENST0000026465108314_452205.0526.0RegionNote=Coil 2
TgeneKRT24chr17:42956924chr17:38858185ENST0000026465108453_525205.0526.0RegionNote=Tail

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEFTUD2chr17:42956923chr17:38858185ENST00000402521-827127_409199.0938.0Domaintr-type G
HgeneEFTUD2chr17:42956923chr17:38858185ENST00000426333-928127_409234.0973.0Domaintr-type G
HgeneEFTUD2chr17:42956923chr17:38858185ENST00000591382-928127_409234.0973.0Domaintr-type G
HgeneEFTUD2chr17:42956924chr17:38858185ENST00000402521-827127_409199.0938.0Domaintr-type G
HgeneEFTUD2chr17:42956924chr17:38858185ENST00000426333-928127_409234.0973.0Domaintr-type G
HgeneEFTUD2chr17:42956924chr17:38858185ENST00000591382-928127_409234.0973.0Domaintr-type G
HgeneEFTUD2chr17:42956923chr17:38858185ENST00000402521-827204_208199.0938.0Nucleotide bindingGTP
HgeneEFTUD2chr17:42956923chr17:38858185ENST00000402521-827258_261199.0938.0Nucleotide bindingGTP
HgeneEFTUD2chr17:42956923chr17:38858185ENST00000426333-928258_261234.0973.0Nucleotide bindingGTP
HgeneEFTUD2chr17:42956923chr17:38858185ENST00000591382-928258_261234.0973.0Nucleotide bindingGTP
HgeneEFTUD2chr17:42956924chr17:38858185ENST00000402521-827204_208199.0938.0Nucleotide bindingGTP
HgeneEFTUD2chr17:42956924chr17:38858185ENST00000402521-827258_261199.0938.0Nucleotide bindingGTP
HgeneEFTUD2chr17:42956924chr17:38858185ENST00000426333-928258_261234.0973.0Nucleotide bindingGTP
HgeneEFTUD2chr17:42956924chr17:38858185ENST00000591382-928258_261234.0973.0Nucleotide bindingGTP
TgeneKRT24chr17:42956923chr17:38858185ENST000002646510813_138205.0526.0Compositional biasNote=Gly-rich
TgeneKRT24chr17:42956924chr17:38858185ENST000002646510813_138205.0526.0Compositional biasNote=Gly-rich
TgeneKRT24chr17:42956923chr17:38858185ENST0000026465108140_456205.0526.0DomainIF rod
TgeneKRT24chr17:42956924chr17:38858185ENST0000026465108140_456205.0526.0DomainIF rod
TgeneKRT24chr17:42956923chr17:38858185ENST0000026465108140_175205.0526.0RegionNote=Coil 1A
TgeneKRT24chr17:42956923chr17:38858185ENST0000026465108176_198205.0526.0RegionNote=Linker 1
TgeneKRT24chr17:42956923chr17:38858185ENST0000026465108199_290205.0526.0RegionNote=Coil 1B
TgeneKRT24chr17:42956923chr17:38858185ENST00000264651081_139205.0526.0RegionNote=Head
TgeneKRT24chr17:42956924chr17:38858185ENST0000026465108140_175205.0526.0RegionNote=Coil 1A
TgeneKRT24chr17:42956924chr17:38858185ENST0000026465108176_198205.0526.0RegionNote=Linker 1
TgeneKRT24chr17:42956924chr17:38858185ENST0000026465108199_290205.0526.0RegionNote=Coil 1B
TgeneKRT24chr17:42956924chr17:38858185ENST00000264651081_139205.0526.0RegionNote=Head


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Fusion Gene Sequence for EFTUD2-KRT24


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000591382_ENST00000264651_TCGA-CN-5370_EFTUD2_chr17_42956923_-_KRT24_chr17_38858185_length(transcript)=2309nt_BP=1100nt
GTAAGTTGAAGCGGGTCAGCGGCACGGAAGGGTTGCTCCAGGTGGGATAGGAAATTAAAAAGCGTCAGATCTGGAAGGGGCCTTATATGC
TATTGGCCCCTTTCGCTTTACGGATCGGTAAATTGAGGCCTGGAGCGGGAAAAAGAATGGAAGACCCTGTCGTCCTCGTGCCTTCCCAAG
GCTTCCGAAGCGCGCACACACGCACACACCTCGATTTCGGGGCTGCCTCTATAGCCTCAGTCCGTAAAATCGTATCGCTAGGTAGGAGTG
GTGCTCTAACTGTCCAGTCCCCTCGCTCACTTCCTCTTCTATCCGTGCCGCTTTCAGCCGTTCTTTGCCAAGTTCCCTCCGAAGTCCTCT
GAGCTCCTGCATTGTAGCGGGAAGCGGCAGTGAGCATCATGGATACCGACTTATATGATGAGTTTGGGAATTATATTGGACCAGAGCTTG
ATTCTGATGAAGATGATGATGAATTGGGTAGAGAGACCAAAGATCTTGATGAGATGGATGATGATGACGACGACGATGACGTAGGAGATC
ATGACGATGACCACCCTGGGATGGAGGTGGTGCTGCATGAGGACAAGAAGTACTACCCAACAGCCGAGGAGGTGTATGGTCCTGAGGTGG
AGACCATAGTTCAAGAGGAAGACACTCAGCCTCTCACAGAACCCATTATTAAGCCAGTGAAAACCAAGAAATTCACTCTGATGGAGCAGA
CATTACCTGTTACGGTGTATGAGATGGATTTCTTGGCGGATCTGATGGATAACTCAGAGCTCATCAGAAATGTGACCCTTTGTGGACATC
TCCACCATGGCAAGACATGTTTTGTGGATTGTTTAATTGAACAGACTCACCCGGAAATCAGAAAGCGCTATGACCAAGATCTGTGCTATA
CTGACATCCTCTTCACAGAGCAAGAGAGAGGTGTAGGCATCAAAAGCACTCCTGTGACAGTGGTCTTGCCAGACACCAAAGGAAAATCTT
ATCTCTTCAATATCATGGACACTCCAGGACATGTGAATTTCTCTGATGAGGTCACAGCTGGCTTGCGCATCTCAGATGGAGTGGTCCTTT
TCATTGATGCTGCTGAGGGGATCATTGCTGCCACTGTTGAAAATGCTGGGATCATTTTGCACATTGACAATGCCAGATTGGCTGCTGATG
ACTTCAGACTGAAGTATGAGAACGAGCTGTGTCTCCGGCAGAGCGTGGAGGCTGACATCAATGGCCTGCGGAAAGTCCTGGATGACCTGA
CTATGACCCGCTCTGACCTGGAGATGCAGATTGAGAGTTTCACCGAGGAGCTAGCCTACCTGAGGAAGAACCACGAGGAGGAAATGAAGA
ATATGCAAGGAAGCTCTGGAGGGGAGGTGACCGTAGAAATGAATGCTGCGCCAGGGACCGACCTGACCAAATTACTGAATGACATGAGGG
CGCAGTACGAGGAGCTGGCTGAGCAAAACCGCCGAGAGGCTGAGGAGCGGTTCAACAAGCAGAGCGCATCACTACAAGCACAAATCTCCA
CTGATGCTGGGGCAGCCACTTCTGCCAAGAATGAGATAACAGAACTAAAACGTACCCTGCAAGCCCTGGAAATTGAGCTTCAGTCCCAAC
TGGCCATGAAAAGCTCCCTGGAGGGAACCCTGGCTGACACAGAAGCTGGCTACGTGGCTCAGCTGTCAGAAATTCAAACGCAGATCAGTG
CCCTGGAGGAGGAGATCTGCCAGATCTGGGGTGAGACTAAATGCCAGAACGCAGAGTACAAGCAATTGCTGGACATCAAGACACGCCTGG
AGGTGGAGATCGAGACCTACCGCCGCCTGCTCGATGGAGAGGGAGGTGGTTCTAGTTTTGCAGAATTTGGTGGTAGAAACTCAGGATCTG
TAAACATGGGATCCAGGGATCTGGTATCTGGTGACTCAAGATCTGGAAGCTGTTCTGGTCAAGGACGAGATTCAAGCAAGACTAGAGTGA
CTAAGACTATCGTAGAGGAGTTGGTGGATGGCAAGGTTGTCTCGTCTCAAGTCAGCAGTATTTCTGAGGTGAAAGTTAAATAAGGAACTT
CCAGATCAACAAAAGTGTCTTTCAAAGAAAAAAAAATCAAGAAGGACACAAGCGAAGAAATGGCATCAATCTAGGCATCTTTCTGGATAA
TTTCAGGAAAAGCTTCAGTCCAGAAATGGATGACTAGCCAACTTTTCTGCATCTTCTTATTTCCTCATTAGAATGCTCTTGAAATAGCTG

>In-frame_ENST00000591382_ENST00000264651_TCGA-CN-5370_EFTUD2_chr17_42956923_-_KRT24_chr17_38858185_length(amino acids)=554AA_start in transcript=398_stop in transcript=2062
MDTDLYDEFGNYIGPELDSDEDDDELGRETKDLDEMDDDDDDDDVGDHDDDHPGMEVVLHEDKKYYPTAEEVYGPEVETIVQEEDTQPLT
EPIIKPVKTKKFTLMEQTLPVTVYEMDFLADLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRKRYDQDLCYTDILFTEQERGVG
IKSTPVTVVLPDTKGKSYLFNIMDTPGHVNFSDEVTAGLRISDGVVLFIDAAEGIIAATVENAGIILHIDNARLAADDFRLKYENELCLR
QSVEADINGLRKVLDDLTMTRSDLEMQIESFTEELAYLRKNHEEEMKNMQGSSGGEVTVEMNAAPGTDLTKLLNDMRAQYEELAEQNRRE
AEERFNKQSASLQAQISTDAGAATSAKNEITELKRTLQALEIELQSQLAMKSSLEGTLADTEAGYVAQLSEIQTQISALEEEICQIWGET
KCQNAEYKQLLDIKTRLEVEIETYRRLLDGEGGGSSFAEFGGRNSGSVNMGSRDLVSGDSRSGSCSGQGRDSSKTRVTKTIVEELVDGKV

--------------------------------------------------------------
>In-frame_ENST00000402521_ENST00000264651_TCGA-CN-5370_EFTUD2_chr17_42956923_-_KRT24_chr17_38858185_length(transcript)=1883nt_BP=674nt
GCAGGCGTTTCCTCGGCGTGGGGCGGAAGCACGATCTCCGGCAGCGGCCTGGGAACTCTTAGCTGAGCAGGCGAGAGATGGATGATGATG
ACGACGACGATGACGTAGGAGATCATGACGATGACCACCCTGGGATGGAGGTGGTGCTGCATGAGGACAAGAAGTACTACCCAACAGCCG
AGGAGGTGTATGGTCCTGAGGTGGAGACCATAGTTCAAGAGGAAGACACTCAGCCTCTCACAGAACCCATTATTAAGCCAGTGAAAACCA
AGAAATTCACTCTGATGGAGCAGACATTACCTGTTACGGTGTATGAGATGGATTTCTTGGCGGATCTGATGGATAACTCAGAGCTCATCA
GAAATGTGACCCTTTGTGGACATCTCCACCATGGCAAGACATGTTTTGTGGATTGTTTAATTGAACAGACTCACCCGGAAATCAGAAAGC
GCTATGACCAAGATCTGTGCTATACTGACATCCTCTTCACAGAGCAAGAGAGAGGTGTAGGCATCAAAAGCACTCCTGTGACAGTGGTCT
TGCCAGACACCAAAGGAAAATCTTATCTCTTCAATATCATGGACACTCCAGGACATGTGAATTTCTCTGATGAGGTCACAGCTGGCTTGC
GCATCTCAGATGGAGTGGTCCTTTTCATTGATGCTGCTGAGGGGATCATTGCTGCCACTGTTGAAAATGCTGGGATCATTTTGCACATTG
ACAATGCCAGATTGGCTGCTGATGACTTCAGACTGAAGTATGAGAACGAGCTGTGTCTCCGGCAGAGCGTGGAGGCTGACATCAATGGCC
TGCGGAAAGTCCTGGATGACCTGACTATGACCCGCTCTGACCTGGAGATGCAGATTGAGAGTTTCACCGAGGAGCTAGCCTACCTGAGGA
AGAACCACGAGGAGGAAATGAAGAATATGCAAGGAAGCTCTGGAGGGGAGGTGACCGTAGAAATGAATGCTGCGCCAGGGACCGACCTGA
CCAAATTACTGAATGACATGAGGGCGCAGTACGAGGAGCTGGCTGAGCAAAACCGCCGAGAGGCTGAGGAGCGGTTCAACAAGCAGAGCG
CATCACTACAAGCACAAATCTCCACTGATGCTGGGGCAGCCACTTCTGCCAAGAATGAGATAACAGAACTAAAACGTACCCTGCAAGCCC
TGGAAATTGAGCTTCAGTCCCAACTGGCCATGAAAAGCTCCCTGGAGGGAACCCTGGCTGACACAGAAGCTGGCTACGTGGCTCAGCTGT
CAGAAATTCAAACGCAGATCAGTGCCCTGGAGGAGGAGATCTGCCAGATCTGGGGTGAGACTAAATGCCAGAACGCAGAGTACAAGCAAT
TGCTGGACATCAAGACACGCCTGGAGGTGGAGATCGAGACCTACCGCCGCCTGCTCGATGGAGAGGGAGGTGGTTCTAGTTTTGCAGAAT
TTGGTGGTAGAAACTCAGGATCTGTAAACATGGGATCCAGGGATCTGGTATCTGGTGACTCAAGATCTGGAAGCTGTTCTGGTCAAGGAC
GAGATTCAAGCAAGACTAGAGTGACTAAGACTATCGTAGAGGAGTTGGTGGATGGCAAGGTTGTCTCGTCTCAAGTCAGCAGTATTTCTG
AGGTGAAAGTTAAATAAGGAACTTCCAGATCAACAAAAGTGTCTTTCAAAGAAAAAAAAATCAAGAAGGACACAAGCGAAGAAATGGCAT
CAATCTAGGCATCTTTCTGGATAATTTCAGGAAAAGCTTCAGTCCAGAAATGGATGACTAGCCAACTTTTCTGCATCTTCTTATTTCCTC

>In-frame_ENST00000402521_ENST00000264651_TCGA-CN-5370_EFTUD2_chr17_42956923_-_KRT24_chr17_38858185_length(amino acids)=524AA_start in transcript=62_stop in transcript=1636
MSRREMDDDDDDDDVGDHDDDHPGMEVVLHEDKKYYPTAEEVYGPEVETIVQEEDTQPLTEPIIKPVKTKKFTLMEQTLPVTVYEMDFLA
DLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRKRYDQDLCYTDILFTEQERGVGIKSTPVTVVLPDTKGKSYLFNIMDTPGHVN
FSDEVTAGLRISDGVVLFIDAAEGIIAATVENAGIILHIDNARLAADDFRLKYENELCLRQSVEADINGLRKVLDDLTMTRSDLEMQIES
FTEELAYLRKNHEEEMKNMQGSSGGEVTVEMNAAPGTDLTKLLNDMRAQYEELAEQNRREAEERFNKQSASLQAQISTDAGAATSAKNEI
TELKRTLQALEIELQSQLAMKSSLEGTLADTEAGYVAQLSEIQTQISALEEEICQIWGETKCQNAEYKQLLDIKTRLEVEIETYRRLLDG

--------------------------------------------------------------
>In-frame_ENST00000591382_ENST00000264651_TCGA-CN-5370_EFTUD2_chr17_42956924_-_KRT24_chr17_38858185_length(transcript)=2309nt_BP=1100nt
GTAAGTTGAAGCGGGTCAGCGGCACGGAAGGGTTGCTCCAGGTGGGATAGGAAATTAAAAAGCGTCAGATCTGGAAGGGGCCTTATATGC
TATTGGCCCCTTTCGCTTTACGGATCGGTAAATTGAGGCCTGGAGCGGGAAAAAGAATGGAAGACCCTGTCGTCCTCGTGCCTTCCCAAG
GCTTCCGAAGCGCGCACACACGCACACACCTCGATTTCGGGGCTGCCTCTATAGCCTCAGTCCGTAAAATCGTATCGCTAGGTAGGAGTG
GTGCTCTAACTGTCCAGTCCCCTCGCTCACTTCCTCTTCTATCCGTGCCGCTTTCAGCCGTTCTTTGCCAAGTTCCCTCCGAAGTCCTCT
GAGCTCCTGCATTGTAGCGGGAAGCGGCAGTGAGCATCATGGATACCGACTTATATGATGAGTTTGGGAATTATATTGGACCAGAGCTTG
ATTCTGATGAAGATGATGATGAATTGGGTAGAGAGACCAAAGATCTTGATGAGATGGATGATGATGACGACGACGATGACGTAGGAGATC
ATGACGATGACCACCCTGGGATGGAGGTGGTGCTGCATGAGGACAAGAAGTACTACCCAACAGCCGAGGAGGTGTATGGTCCTGAGGTGG
AGACCATAGTTCAAGAGGAAGACACTCAGCCTCTCACAGAACCCATTATTAAGCCAGTGAAAACCAAGAAATTCACTCTGATGGAGCAGA
CATTACCTGTTACGGTGTATGAGATGGATTTCTTGGCGGATCTGATGGATAACTCAGAGCTCATCAGAAATGTGACCCTTTGTGGACATC
TCCACCATGGCAAGACATGTTTTGTGGATTGTTTAATTGAACAGACTCACCCGGAAATCAGAAAGCGCTATGACCAAGATCTGTGCTATA
CTGACATCCTCTTCACAGAGCAAGAGAGAGGTGTAGGCATCAAAAGCACTCCTGTGACAGTGGTCTTGCCAGACACCAAAGGAAAATCTT
ATCTCTTCAATATCATGGACACTCCAGGACATGTGAATTTCTCTGATGAGGTCACAGCTGGCTTGCGCATCTCAGATGGAGTGGTCCTTT
TCATTGATGCTGCTGAGGGGATCATTGCTGCCACTGTTGAAAATGCTGGGATCATTTTGCACATTGACAATGCCAGATTGGCTGCTGATG
ACTTCAGACTGAAGTATGAGAACGAGCTGTGTCTCCGGCAGAGCGTGGAGGCTGACATCAATGGCCTGCGGAAAGTCCTGGATGACCTGA
CTATGACCCGCTCTGACCTGGAGATGCAGATTGAGAGTTTCACCGAGGAGCTAGCCTACCTGAGGAAGAACCACGAGGAGGAAATGAAGA
ATATGCAAGGAAGCTCTGGAGGGGAGGTGACCGTAGAAATGAATGCTGCGCCAGGGACCGACCTGACCAAATTACTGAATGACATGAGGG
CGCAGTACGAGGAGCTGGCTGAGCAAAACCGCCGAGAGGCTGAGGAGCGGTTCAACAAGCAGAGCGCATCACTACAAGCACAAATCTCCA
CTGATGCTGGGGCAGCCACTTCTGCCAAGAATGAGATAACAGAACTAAAACGTACCCTGCAAGCCCTGGAAATTGAGCTTCAGTCCCAAC
TGGCCATGAAAAGCTCCCTGGAGGGAACCCTGGCTGACACAGAAGCTGGCTACGTGGCTCAGCTGTCAGAAATTCAAACGCAGATCAGTG
CCCTGGAGGAGGAGATCTGCCAGATCTGGGGTGAGACTAAATGCCAGAACGCAGAGTACAAGCAATTGCTGGACATCAAGACACGCCTGG
AGGTGGAGATCGAGACCTACCGCCGCCTGCTCGATGGAGAGGGAGGTGGTTCTAGTTTTGCAGAATTTGGTGGTAGAAACTCAGGATCTG
TAAACATGGGATCCAGGGATCTGGTATCTGGTGACTCAAGATCTGGAAGCTGTTCTGGTCAAGGACGAGATTCAAGCAAGACTAGAGTGA
CTAAGACTATCGTAGAGGAGTTGGTGGATGGCAAGGTTGTCTCGTCTCAAGTCAGCAGTATTTCTGAGGTGAAAGTTAAATAAGGAACTT
CCAGATCAACAAAAGTGTCTTTCAAAGAAAAAAAAATCAAGAAGGACACAAGCGAAGAAATGGCATCAATCTAGGCATCTTTCTGGATAA
TTTCAGGAAAAGCTTCAGTCCAGAAATGGATGACTAGCCAACTTTTCTGCATCTTCTTATTTCCTCATTAGAATGCTCTTGAAATAGCTG

>In-frame_ENST00000591382_ENST00000264651_TCGA-CN-5370_EFTUD2_chr17_42956924_-_KRT24_chr17_38858185_length(amino acids)=554AA_start in transcript=398_stop in transcript=2062
MDTDLYDEFGNYIGPELDSDEDDDELGRETKDLDEMDDDDDDDDVGDHDDDHPGMEVVLHEDKKYYPTAEEVYGPEVETIVQEEDTQPLT
EPIIKPVKTKKFTLMEQTLPVTVYEMDFLADLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRKRYDQDLCYTDILFTEQERGVG
IKSTPVTVVLPDTKGKSYLFNIMDTPGHVNFSDEVTAGLRISDGVVLFIDAAEGIIAATVENAGIILHIDNARLAADDFRLKYENELCLR
QSVEADINGLRKVLDDLTMTRSDLEMQIESFTEELAYLRKNHEEEMKNMQGSSGGEVTVEMNAAPGTDLTKLLNDMRAQYEELAEQNRRE
AEERFNKQSASLQAQISTDAGAATSAKNEITELKRTLQALEIELQSQLAMKSSLEGTLADTEAGYVAQLSEIQTQISALEEEICQIWGET
KCQNAEYKQLLDIKTRLEVEIETYRRLLDGEGGGSSFAEFGGRNSGSVNMGSRDLVSGDSRSGSCSGQGRDSSKTRVTKTIVEELVDGKV

--------------------------------------------------------------
>In-frame_ENST00000402521_ENST00000264651_TCGA-CN-5370_EFTUD2_chr17_42956924_-_KRT24_chr17_38858185_length(transcript)=1883nt_BP=674nt
GCAGGCGTTTCCTCGGCGTGGGGCGGAAGCACGATCTCCGGCAGCGGCCTGGGAACTCTTAGCTGAGCAGGCGAGAGATGGATGATGATG
ACGACGACGATGACGTAGGAGATCATGACGATGACCACCCTGGGATGGAGGTGGTGCTGCATGAGGACAAGAAGTACTACCCAACAGCCG
AGGAGGTGTATGGTCCTGAGGTGGAGACCATAGTTCAAGAGGAAGACACTCAGCCTCTCACAGAACCCATTATTAAGCCAGTGAAAACCA
AGAAATTCACTCTGATGGAGCAGACATTACCTGTTACGGTGTATGAGATGGATTTCTTGGCGGATCTGATGGATAACTCAGAGCTCATCA
GAAATGTGACCCTTTGTGGACATCTCCACCATGGCAAGACATGTTTTGTGGATTGTTTAATTGAACAGACTCACCCGGAAATCAGAAAGC
GCTATGACCAAGATCTGTGCTATACTGACATCCTCTTCACAGAGCAAGAGAGAGGTGTAGGCATCAAAAGCACTCCTGTGACAGTGGTCT
TGCCAGACACCAAAGGAAAATCTTATCTCTTCAATATCATGGACACTCCAGGACATGTGAATTTCTCTGATGAGGTCACAGCTGGCTTGC
GCATCTCAGATGGAGTGGTCCTTTTCATTGATGCTGCTGAGGGGATCATTGCTGCCACTGTTGAAAATGCTGGGATCATTTTGCACATTG
ACAATGCCAGATTGGCTGCTGATGACTTCAGACTGAAGTATGAGAACGAGCTGTGTCTCCGGCAGAGCGTGGAGGCTGACATCAATGGCC
TGCGGAAAGTCCTGGATGACCTGACTATGACCCGCTCTGACCTGGAGATGCAGATTGAGAGTTTCACCGAGGAGCTAGCCTACCTGAGGA
AGAACCACGAGGAGGAAATGAAGAATATGCAAGGAAGCTCTGGAGGGGAGGTGACCGTAGAAATGAATGCTGCGCCAGGGACCGACCTGA
CCAAATTACTGAATGACATGAGGGCGCAGTACGAGGAGCTGGCTGAGCAAAACCGCCGAGAGGCTGAGGAGCGGTTCAACAAGCAGAGCG
CATCACTACAAGCACAAATCTCCACTGATGCTGGGGCAGCCACTTCTGCCAAGAATGAGATAACAGAACTAAAACGTACCCTGCAAGCCC
TGGAAATTGAGCTTCAGTCCCAACTGGCCATGAAAAGCTCCCTGGAGGGAACCCTGGCTGACACAGAAGCTGGCTACGTGGCTCAGCTGT
CAGAAATTCAAACGCAGATCAGTGCCCTGGAGGAGGAGATCTGCCAGATCTGGGGTGAGACTAAATGCCAGAACGCAGAGTACAAGCAAT
TGCTGGACATCAAGACACGCCTGGAGGTGGAGATCGAGACCTACCGCCGCCTGCTCGATGGAGAGGGAGGTGGTTCTAGTTTTGCAGAAT
TTGGTGGTAGAAACTCAGGATCTGTAAACATGGGATCCAGGGATCTGGTATCTGGTGACTCAAGATCTGGAAGCTGTTCTGGTCAAGGAC
GAGATTCAAGCAAGACTAGAGTGACTAAGACTATCGTAGAGGAGTTGGTGGATGGCAAGGTTGTCTCGTCTCAAGTCAGCAGTATTTCTG
AGGTGAAAGTTAAATAAGGAACTTCCAGATCAACAAAAGTGTCTTTCAAAGAAAAAAAAATCAAGAAGGACACAAGCGAAGAAATGGCAT
CAATCTAGGCATCTTTCTGGATAATTTCAGGAAAAGCTTCAGTCCAGAAATGGATGACTAGCCAACTTTTCTGCATCTTCTTATTTCCTC

>In-frame_ENST00000402521_ENST00000264651_TCGA-CN-5370_EFTUD2_chr17_42956924_-_KRT24_chr17_38858185_length(amino acids)=524AA_start in transcript=62_stop in transcript=1636
MSRREMDDDDDDDDVGDHDDDHPGMEVVLHEDKKYYPTAEEVYGPEVETIVQEEDTQPLTEPIIKPVKTKKFTLMEQTLPVTVYEMDFLA
DLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRKRYDQDLCYTDILFTEQERGVGIKSTPVTVVLPDTKGKSYLFNIMDTPGHVN
FSDEVTAGLRISDGVVLFIDAAEGIIAATVENAGIILHIDNARLAADDFRLKYENELCLRQSVEADINGLRKVLDDLTMTRSDLEMQIES
FTEELAYLRKNHEEEMKNMQGSSGGEVTVEMNAAPGTDLTKLLNDMRAQYEELAEQNRREAEERFNKQSASLQAQISTDAGAATSAKNEI
TELKRTLQALEIELQSQLAMKSSLEGTLADTEAGYVAQLSEIQTQISALEEEICQIWGETKCQNAEYKQLLDIKTRLEVEIETYRRLLDG

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Fusion Gene PPI Analysis for EFTUD2-KRT24


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EFTUD2-KRT24


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EFTUD2-KRT24


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEFTUD2C1864652Growth and mental retardation, mandibulofacial dysostosis, microcephaly, and cleft palate5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneEFTUD2C0152423Congenital small ears1GENOMICS_ENGLAND