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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EGFR-ATXN7L1 (FusionGDB2 ID:25423)

Fusion Gene Summary for EGFR-ATXN7L1

check button Fusion gene summary
Fusion gene informationFusion gene name: EGFR-ATXN7L1
Fusion gene ID: 25423
HgeneTgene
Gene symbol

EGFR

ATXN7L1

Gene ID

1956

222255

Gene nameepidermal growth factor receptorataxin 7 like 1
SynonymsERBB|ERBB1|HER1|NISBD2|PIG61|mENAATXN7L4
Cytomap

7p11.2

7q22.3

Type of geneprotein-codingprotein-coding
Descriptionepidermal growth factor receptoravian erythroblastic leukemia viral (v-erb-b) oncogene homologcell growth inhibiting protein 40cell proliferation-inducing protein 61epidermal growth factor receptor tyrosine kinase domainerb-b2 receptor tyrosine kinasataxin-7-like protein 1ataxin 7-like 4ataxin-7-like protein 4
Modification date2020032920200313
UniProtAcc

P00533

Q9ULK2

Ensembl transtripts involved in fusion geneENST00000455089, ENST00000342916, 
ENST00000344576, ENST00000420316, 
ENST00000275493, ENST00000442591, 
ENST00000463948, ENST00000454757, 
ENST00000419735, ENST00000477775, 
ENST00000318724, ENST00000478915, 
ENST00000388807, ENST00000472910, 
Fusion gene scores* DoF score41 X 25 X 14=1435012 X 8 X 5=480
# samples 5312
** MAII scorelog2(53/14350*10)=-4.75891456699985
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/480*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EGFR [Title/Abstract] AND ATXN7L1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATXN7L1(105516257)-EGFR(55209978), # samples:1
EGFR(55269475)-ATXN7L1(105251050), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEGFR

GO:0001934

positive regulation of protein phosphorylation

20551055

HgeneEGFR

GO:0007165

signal transduction

10572067

HgeneEGFR

GO:0007166

cell surface receptor signaling pathway

7736574

HgeneEGFR

GO:0007173

epidermal growth factor receptor signaling pathway

7736574|12435727

HgeneEGFR

GO:0008283

cell proliferation

17115032

HgeneEGFR

GO:0008284

positive regulation of cell proliferation

7736574

HgeneEGFR

GO:0010750

positive regulation of nitric oxide mediated signal transduction

12828935

HgeneEGFR

GO:0018108

peptidyl-tyrosine phosphorylation

22732145

HgeneEGFR

GO:0030307

positive regulation of cell growth

15467833

HgeneEGFR

GO:0042177

negative regulation of protein catabolic process

17115032

HgeneEGFR

GO:0042327

positive regulation of phosphorylation

15082764

HgeneEGFR

GO:0043406

positive regulation of MAP kinase activity

10572067

HgeneEGFR

GO:0045739

positive regulation of DNA repair

17115032

HgeneEGFR

GO:0045740

positive regulation of DNA replication

17115032

HgeneEGFR

GO:0045944

positive regulation of transcription by RNA polymerase II

20551055

HgeneEGFR

GO:0050679

positive regulation of epithelial cell proliferation

10572067

HgeneEGFR

GO:0050999

regulation of nitric-oxide synthase activity

12828935

HgeneEGFR

GO:0070141

response to UV-A

18483258

HgeneEGFR

GO:0070374

positive regulation of ERK1 and ERK2 cascade

20551055

HgeneEGFR

GO:0071392

cellular response to estradiol stimulus

20551055

HgeneEGFR

GO:1900020

positive regulation of protein kinase C activity

22732145

HgeneEGFR

GO:1903078

positive regulation of protein localization to plasma membrane

22732145


check buttonFusion gene breakpoints across EGFR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ATXN7L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-AA6IEGFRchr7

55269475

+ATXN7L1chr7

105251050

-


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Fusion Gene ORF analysis for EGFR-ATXN7L1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000455089ENST00000419735EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
In-frameENST00000455089ENST00000477775EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
5CDS-intronENST00000455089ENST00000318724EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
5CDS-intronENST00000455089ENST00000478915EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
5CDS-intronENST00000455089ENST00000388807EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
5CDS-intronENST00000455089ENST00000472910EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
intron-3CDSENST00000342916ENST00000419735EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
intron-3CDSENST00000342916ENST00000477775EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
intron-intronENST00000342916ENST00000318724EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
intron-intronENST00000342916ENST00000478915EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
intron-intronENST00000342916ENST00000388807EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
intron-intronENST00000342916ENST00000472910EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
intron-3CDSENST00000344576ENST00000419735EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
intron-3CDSENST00000344576ENST00000477775EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
intron-intronENST00000344576ENST00000318724EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
intron-intronENST00000344576ENST00000478915EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
intron-intronENST00000344576ENST00000388807EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
intron-intronENST00000344576ENST00000472910EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
intron-3CDSENST00000420316ENST00000419735EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
intron-3CDSENST00000420316ENST00000477775EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
intron-intronENST00000420316ENST00000318724EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
intron-intronENST00000420316ENST00000478915EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
intron-intronENST00000420316ENST00000388807EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
intron-intronENST00000420316ENST00000472910EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
In-frameENST00000275493ENST00000419735EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
In-frameENST00000275493ENST00000477775EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
5CDS-intronENST00000275493ENST00000318724EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
5CDS-intronENST00000275493ENST00000478915EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
5CDS-intronENST00000275493ENST00000388807EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
5CDS-intronENST00000275493ENST00000472910EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
intron-3CDSENST00000442591ENST00000419735EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
intron-3CDSENST00000442591ENST00000477775EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
intron-intronENST00000442591ENST00000318724EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
intron-intronENST00000442591ENST00000478915EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
intron-intronENST00000442591ENST00000388807EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
intron-intronENST00000442591ENST00000472910EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
intron-3CDSENST00000463948ENST00000419735EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
intron-3CDSENST00000463948ENST00000477775EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
intron-intronENST00000463948ENST00000318724EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
intron-intronENST00000463948ENST00000478915EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
intron-intronENST00000463948ENST00000388807EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
intron-intronENST00000463948ENST00000472910EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
In-frameENST00000454757ENST00000419735EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
In-frameENST00000454757ENST00000477775EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
5CDS-intronENST00000454757ENST00000318724EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
5CDS-intronENST00000454757ENST00000478915EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
5CDS-intronENST00000454757ENST00000388807EGFRchr7

55269475

+ATXN7L1chr7

105251050

-
5CDS-intronENST00000454757ENST00000472910EGFRchr7

55269475

+ATXN7L1chr7

105251050

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000455089EGFRchr755269475+ENST00000419735ATXN7L1chr7105251050-6183328425733971046
ENST00000455089EGFRchr755269475+ENST00000477775ATXN7L1chr7105251050-3482328425734001047
ENST00000275493EGFRchr755269475+ENST00000419735ATXN7L1chr7105251050-6238333917734521091
ENST00000275493EGFRchr755269475+ENST00000477775ATXN7L1chr7105251050-3537333917734551092
ENST00000454757EGFRchr755269475+ENST00000419735ATXN7L1chr7105251050-6085318614432991051
ENST00000454757EGFRchr755269475+ENST00000477775ATXN7L1chr7105251050-3384318614433021052

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000455089ENST00000419735EGFRchr755269475+ATXN7L1chr7105251050-0.0003576450.9996424
ENST00000455089ENST00000477775EGFRchr755269475+ATXN7L1chr7105251050-0.0011751420.9988249
ENST00000275493ENST00000419735EGFRchr755269475+ATXN7L1chr7105251050-0.0004607250.99953926
ENST00000275493ENST00000477775EGFRchr755269475+ATXN7L1chr7105251050-0.0018308860.99816906
ENST00000454757ENST00000419735EGFRchr755269475+ATXN7L1chr7105251050-0.000409820.9995902
ENST00000454757ENST00000477775EGFRchr755269475+ATXN7L1chr7105251050-0.0014392910.9985607

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Fusion Genomic Features for EGFR-ATXN7L1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EGFR-ATXN7L1


check button Go to

FGviewer for the breakpoints of chr7:55269475-chr7:105251050

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EGFR

P00533

ATXN7L1

Q9ULK2

FUNCTION: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975, PubMed:15611079, PubMed:12297049, PubMed:27153536, PubMed:20837704, PubMed:17909029). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEGFRchr7:55269475chr7:105251050ENST00000275493+2628712_9791054.01211.0DomainProtein kinase
HgeneEGFRchr7:55269475chr7:105251050ENST00000275493+2628718_7261054.01211.0Nucleotide bindingATP
HgeneEGFRchr7:55269475chr7:105251050ENST00000275493+2628790_7911054.01211.0Nucleotide bindingATP
HgeneEGFRchr7:55269475chr7:105251050ENST00000275493+2628688_7041054.01211.0RegionNote=Important for dimerization%2C phosphorylation and activation
HgeneEGFRchr7:55269475chr7:105251050ENST00000275493+2628390_6001054.01211.0RepeatNote=Approximate
HgeneEGFRchr7:55269475chr7:105251050ENST00000275493+262875_3001054.01211.0RepeatNote=Approximate
HgeneEGFRchr7:55269475chr7:105251050ENST00000275493+262825_6451054.01211.0Topological domainExtracellular
HgeneEGFRchr7:55269475chr7:105251050ENST00000275493+2628646_6681054.01211.0TransmembraneHelical
TgeneATXN7L1chr7:55269475chr7:105251050ENST0000031872404364_4170147.0Compositional biasNote=Ser-rich
TgeneATXN7L1chr7:55269475chr7:105251050ENST0000031872404536_8470147.0Compositional biasNote=Ser-rich
TgeneATXN7L1chr7:55269475chr7:105251050ENST0000031872404284_3510147.0DomainSCA7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEGFRchr7:55269475chr7:105251050ENST00000342916+116712_9790629.0DomainProtein kinase
HgeneEGFRchr7:55269475chr7:105251050ENST00000344576+116712_9790706.0DomainProtein kinase
HgeneEGFRchr7:55269475chr7:105251050ENST00000420316+110712_9790406.0DomainProtein kinase
HgeneEGFRchr7:55269475chr7:105251050ENST00000342916+116718_7260629.0Nucleotide bindingATP
HgeneEGFRchr7:55269475chr7:105251050ENST00000342916+116790_7910629.0Nucleotide bindingATP
HgeneEGFRchr7:55269475chr7:105251050ENST00000344576+116718_7260706.0Nucleotide bindingATP
HgeneEGFRchr7:55269475chr7:105251050ENST00000344576+116790_7910706.0Nucleotide bindingATP
HgeneEGFRchr7:55269475chr7:105251050ENST00000420316+110718_7260406.0Nucleotide bindingATP
HgeneEGFRchr7:55269475chr7:105251050ENST00000420316+110790_7910406.0Nucleotide bindingATP
HgeneEGFRchr7:55269475chr7:105251050ENST00000342916+116688_7040629.0RegionNote=Important for dimerization%2C phosphorylation and activation
HgeneEGFRchr7:55269475chr7:105251050ENST00000344576+116688_7040706.0RegionNote=Important for dimerization%2C phosphorylation and activation
HgeneEGFRchr7:55269475chr7:105251050ENST00000420316+110688_7040406.0RegionNote=Important for dimerization%2C phosphorylation and activation
HgeneEGFRchr7:55269475chr7:105251050ENST00000342916+116390_6000629.0RepeatNote=Approximate
HgeneEGFRchr7:55269475chr7:105251050ENST00000342916+11675_3000629.0RepeatNote=Approximate
HgeneEGFRchr7:55269475chr7:105251050ENST00000344576+116390_6000706.0RepeatNote=Approximate
HgeneEGFRchr7:55269475chr7:105251050ENST00000344576+11675_3000706.0RepeatNote=Approximate
HgeneEGFRchr7:55269475chr7:105251050ENST00000420316+110390_6000406.0RepeatNote=Approximate
HgeneEGFRchr7:55269475chr7:105251050ENST00000420316+11075_3000406.0RepeatNote=Approximate
HgeneEGFRchr7:55269475chr7:105251050ENST00000275493+2628669_12101054.01211.0Topological domainCytoplasmic
HgeneEGFRchr7:55269475chr7:105251050ENST00000342916+11625_6450629.0Topological domainExtracellular
HgeneEGFRchr7:55269475chr7:105251050ENST00000342916+116669_12100629.0Topological domainCytoplasmic
HgeneEGFRchr7:55269475chr7:105251050ENST00000344576+11625_6450706.0Topological domainExtracellular
HgeneEGFRchr7:55269475chr7:105251050ENST00000344576+116669_12100706.0Topological domainCytoplasmic
HgeneEGFRchr7:55269475chr7:105251050ENST00000420316+11025_6450406.0Topological domainExtracellular
HgeneEGFRchr7:55269475chr7:105251050ENST00000420316+110669_12100406.0Topological domainCytoplasmic
HgeneEGFRchr7:55269475chr7:105251050ENST00000342916+116646_6680629.0TransmembraneHelical
HgeneEGFRchr7:55269475chr7:105251050ENST00000344576+116646_6680706.0TransmembraneHelical
HgeneEGFRchr7:55269475chr7:105251050ENST00000420316+110646_6680406.0TransmembraneHelical
TgeneATXN7L1chr7:55269475chr7:105251050ENST00000419735912364_417824.0862.0Compositional biasNote=Ser-rich
TgeneATXN7L1chr7:55269475chr7:105251050ENST00000419735912536_847824.0862.0Compositional biasNote=Ser-rich
TgeneATXN7L1chr7:55269475chr7:105251050ENST00000477775710364_417700.0739.0Compositional biasNote=Ser-rich
TgeneATXN7L1chr7:55269475chr7:105251050ENST00000477775710536_847700.0739.0Compositional biasNote=Ser-rich
TgeneATXN7L1chr7:55269475chr7:105251050ENST00000419735912284_351824.0862.0DomainSCA7
TgeneATXN7L1chr7:55269475chr7:105251050ENST00000477775710284_351700.0739.0DomainSCA7


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Fusion Gene Sequence for EGFR-ATXN7L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000455089_ENST00000419735_TCGA-VQ-AA6I_EGFR_chr7_55269475_+_ATXN7L1_chr7_105251050_length(transcript)=6183nt_BP=3284nt
GTCCGGGCAGCCCCCGGCGCAGCGCGGCCGCAGCAGCCTCCGCCCCCCGCACGGTGTGAGCGCCCGACGCGGCCGAGGCGGCCGGAGTCC
CGAGCTAGCCCCGGCGGCCGCCGCCGCCCAGACCGGACGACAGGCCACCTCGTCGGCGTCCGCCCGAGTCCCCGCCTCGCCGCCAACGCC
ACAACCACCGCGCACGGCCCCCTGACTCCGTCCAGTATTGATCGGGAGAGCCGGAGCGAGCTCTTCGGGGAGCAGCGATGCGACCCTCCG
GGACGGCCGGGGCAGCGCTCCTGGCGCTGCTGGCTGCGCTCTGCCCGGCGAGTCGGGCTCTGGAGGAAAAGAAAGTTTGCCAAGGCACGA
GTAACAAGCTCACGCAGTTGGGCACTTTTGAAGATCATTTTCTCAGCCTCCAGAGGATGTTCAATAACTGTGAGGTGGTCCTTGGGAATT
TGGAAATTACCTATGTGCAGAGGAATTATGATCTTTCCTTCTTAAAGACCATCCAGGAGGTGGCTGGTTATGTCCTCATTGCCCTCAACA
CAGTGGAGCGAATTCCTTTGGAAAACCTGCAGATCATCAGAGGAAATATGTACTACGAAAATTCCTATGCCTTAGCAGTCTTATCTAACT
ATGATGCAAATAAAACCGGACTGAAGGAGCTGCCCATGAGAAATTTACAGGGCCAAAAGTGTGATCCAAGCTGTCCCAATGGGAGCTGCT
GGGGTGCAGGAGAGGAGAACTGCCAGAAACTGACCAAAATCATCTGTGCCCAGCAGTGCTCCGGGCGCTGCCGTGGCAAGTCCCCCAGTG
ACTGCTGCCACAACCAGTGTGCTGCAGGCTGCACAGGCCCCCGGGAGAGCGACTGCCTGGTCTGCCGCAAATTCCGAGACGAAGCCACGT
GCAAGGACACCTGCCCCCCACTCATGCTCTACAACCCCACCACGTACCAGATGGATGTGAACCCCGAGGGCAAATACAGCTTTGGTGCCA
CCTGCGTGAAGAAGTGTCCCCGTAATTATGTGGTGACAGATCACGGCTCGTGCGTCCGAGCCTGTGGGGCCGACAGCTATGAGATGGAGG
AAGACGGCGTCCGCAAGTGTAAGAAGTGCGAAGGGCCTTGCCGCAAAGTGTGTAACGGAATAGGTATTGGTGAATTTAAAGACTCACTCT
CCATAAATGCTACGAATATTAAACACTTCAAAAACTGCACCTCCATCAGTGGCGATCTCCACATCCTGCCGGTGGCATTTAGGGGTGACT
CCTTCACACATACTCCTCCTCTGGATCCACAGGAACTGGATATTCTGAAAACCGTAAAGGAAATCACAGGGTTTTTGCTGATTCAGGCTT
GGCCTGAAAACAGGACGGACCTCCATGCCTTTGAGAACCTAGAAATCATACGCGGCAGGACCAAGCAACATGGTCAGTTTTCTCTTGCAG
TCGTCAGCCTGAACATAACATCCTTGGGATTACGCTCCCTCAAGGAGATAAGTGATGGAGATGTGATAATTTCAGGAAACAAAAATTTGT
GCTATGCAAATACAATAAACTGGAAAAAACTGTTTGGGACCTCCGGTCAGAAAACCAAAATTATAAGCAACAGAGGTGAAAACAGCTGCA
AGGCCACAGGCCAGGTCTGCCATGCCTTGTGCTCCCCCGAGGGCTGCTGGGGCCCGGAGCCCAGGGACTGCGTCTCTTGCCGGAATGTCA
GCCGAGGCAGGGAATGCGTGGACAAGTGCAACCTTCTGGAGGGTGAGCCAAGGGAGTTTGTGGAGAACTCTGAGTGCATACAGTGCCACC
CAGAGTGCCTGCCTCAGGCCATGAACATCACCTGCACAGGACGGGGACCAGACAACTGTATCCAGTGTGCCCACTACATTGACGGCCCCC
ACTGCGTCAAGACCTGCCCGGCAGGAGTCATGGGAGAAAACAACACCCTGGTCTGGAAGTACGCAGACGCCGGCCATGTGTGCCACCTGT
GCCATCCAAACTGCACCTACGGATGCACTGGGCCAGGTCTTGAAGGCTGTCCAACGAATGGGCCTAAGATCCCGTCCATCGCCACTGGGA
TGGTGGGGGCCCTCCTCTTGCTGCTGGTGGTGGCCCTGGGGATCGGCCTCTTCATGCGAAGGCGCCACATCGTTCGGAAGCGCACGCTGC
GGAGGCTGCTGCAGGAGAGGGAGCTTGTGGAGCCTCTTACACCCAGTGGAGAAGCTCCCAACCAAGCTCTCTTGAGGATCTTGAAGGAAA
CTGAATTCAAAAAGATCAAAGTGCTGGGCTCCGGTGCGTTCGGCACGGTGTATAAGGGACTCTGGATCCCAGAAGGTGAGAAAGTTAAAA
TTCCCGTCGCTATCAAGGAATTAAGAGAAGCAACATCTCCGAAAGCCAACAAGGAAATCCTCGATGAAGCCTACGTGATGGCCAGCGTGG
ACAACCCCCACGTGTGCCGCCTGCTGGGCATCTGCCTCACCTCCACCGTGCAGCTCATCACGCAGCTCATGCCCTTCGGCTGCCTCCTGG
ACTATGTCCGGGAACACAAAGACAATATTGGCTCCCAGTACCTGCTCAACTGGTGTGTGCAGATCGCAAAGGGCATGAACTACTTGGAGG
ACCGTCGCTTGGTGCACCGCGACCTGGCAGCCAGGAACGTACTGGTGAAAACACCGCAGCATGTCAAGATCACAGATTTTGGGCTGGCCA
AACTGCTGGGTGCGGAAGAGAAAGAATACCATGCAGAAGGAGGCAAAGTGCCTATCAAGTGGATGGCATTGGAATCAATTTTACACAGAA
TCTATACCCACCAGAGTGATGTCTGGAGCTACGGGGTGACTGTTTGGGAGTTGATGACCTTTGGATCCAAGCCATATGACGGAATCCCTG
CCAGCGAGATCTCCTCCATCCTGGAGAAAGGAGAACGCCTCCCTCAGCCACCCATATGTACCATCGATGTCTACATGATCATGGTCAAGT
GCTGGATGATAGACGCAGATAGTCGCCCAAAGTTCCGTGAGTTGATCATCGAATTCTCCAAAATGGCCCGAGACCCCCAGCGCTACCTTG
TCATTCAGGGGGATGAAAGAATGCATTTGCCAAGTCCTACAGACTCCAACTTCTACCGTGCCCTGATGGATGAAGAAGACATGGACGACG
TGGTGGATGCCGACGAGTACCTCATCCCACAGCAGGGCTTCTTCAGCAGCCCCTCCACGTCACGGACTCCCCTCCTGAGCTCTCTGAGTG
CAACCAGCAACAATTCCACCGTGGCTTGCATTGATAGAAATGGGGTTGGGAAAAATAGCAGCCTAGCTTTGTCACAATCCAGTCCTTCAA
GTATATCCAGCCCAGGACACAGCCGACAGAACACAAACAGAACGGGCAGGATAAGGACTCTTCCATAACAAGACTATGAAGCCACTTCCA
CATCAATTCCAGGCCACCTAATCCCATCCGAGGAGGCCATGGGGAGGAGGAGGGAGGGGAGTGGGCTGGGGGGAGAGTCTGTTTTCTGTG
CACTCCCTGTGACTCTGGCCTTTCTTCTTCTTTTTTTAATTGACCAATTTTTAGTTAAAAAGGCAAAAGAAGGTGAATTTGAGATTTACA
GAAAACAGTTCCAGTGTTTGGTTTCCGCTGTCTTTCCTTTCATTTGCCATGTTTTTACATTCTTCCAAATTTGGGGTCACTCCCCTAGCT
CCTGATGCTGCTACTGTACCATCCTTTTGCTCCAGCCATGAGAGCAGACATTGCAGAATGTTGGTTCCAGGTTGGCATGCTCTGAAGCTC
TTGAACTGTAGCACAGGCAGAGCCCTTTTTCTTCCTGTCATCTCCACCCGATTCCTTCCATCCCTACGTCTACCACTCTCTGGGTCCTCA
CTGGTCTTCAAAGGACCTGGCTCTCATAGGATCCCCTCAGGATTGTGTGCAGGGAGAGGGGGCTTTGCTGGGGAGGAGCTGGGAGTGGAG
AGTTGGAGGGTGGGTGGGGTTCCCTCATCCAGTTTCCACAGCCCACCATGGCTGGAGCCAAATGCTAGAAGCGAGATTGAGAACAGTGGC
CGTTTAGTGATGTGGTTTACCTAATACCACTGTCCAGCTGTGCAGCTCAGAAAGGATAAACCAGTCAGGGACAGGGGCCAGAACAGGTTT
GGGAAGGTGGCAGCAAGCAGAGCATGGTGGGTAGGAGATGATCCCTAAAAAAACTGGAGACTGTGGTGGTCTGAGCTGGTCAGGAATCTG
CAGAATCCCTTCCAGGAATCAGTGTGCCAGTGCCCACAGCAGGGTGAGCTAGGAGGGAGAAATCCCAGGAAAAAGGTCGTGAGAACCCAG
AAAGCCACTCCATGAGGAGGCACGGTGACCACAGCTGCTAAAGGTTCTTAGGCTGCCTTCCTGGGCTAGGAAGAGCCCCCCAGGGAGAGC
TTCCACAAAAGGGTATGTGTCAAACCTTTTGTCAGAATAAATAATAGCATTTCCCACCCACCCCCATGCCCTGGGCCACAGGGACTTGGT
GGGATCAGCACACCCATGGATCAGCTTTTGCTGTCTTAGAGACAGCCATCCCCATGAAGGAATGGTAAGGACAGCCACTGCTCAGTGAAG
AACAGCCATTTGGAAGAGCCACGCTGGAGCCCTGCAGCCATAGAACTATTCACACTGGAGTTTTAAAAGAAACAGCAATACCATAAGCTC
TAGTAGGGAATCATAATCAGGAAAGGAATTCACAACATAAAATAGGTGTTCTGTGCTATTAATCATGTAACTTTGTATATGATGTATAGC
AAAGATACTGGGAGGTTTTGTTTCATCCTTAAATCAGAAATGAATGCTAGTTTCATAGCTGGGCAGAACCCTCATCCCCACCCCAAAGTT
TTCCTTTTCTTTCCCGTTCCCCCAACCCAAAGATCAGACTACTGTTAAGTTTCACCACACAATTGGAATTGCAAAGACGGGAGGCAAATG
GAGTGATTTTCATCAATGGAATTGCACTGACAGTGAGTGTTTCTTATAGGATTACTAAATTTTTTAATATAAAATGATTTGTTTAAAAAT
CAGGAGTTGATATTAAGTACCAGGACATTAGTTCGGATGATTTCATTTTTATTTCTACAGTGTTAAAAGTGCACTTATATGCTGGTTTAT
TTACGTCTTGGGAAAAGAGACTGCAAATTGAAGGGATGATTGTTACTTTTTCTTTTTTTAAAAAAAAAAGGTTAAGGAGATTTTAAGACT
TATAAATGTTTAAGAAATTATAAACAAGGTTAGACCCTTTGAAAAAAAGTTTAGAAGATATTCTTAAAGTAAATTTTTATAGTGTTAATT
TTGTAATAATTTATGTTTTACTATATTACAGAGCTAACTGACCAGAATAGTTTCAGAAACAATATGAAACTTAGGAAAGTTTAAGCAATG
TTTATATTTTTAAAATGTTCTTTGAATTATGTTTTTATTGTACATTTCTTCAGACTGAAAAGTATGTACATATCTTTGTTATTTTTGCAC
AATTTTGTCTTGTTCGGTTTCAGAGGTCTGTTGTTTTTTATAATTTATTTTGAGTTGTAAAACTTGCAGGAGTAAAAACAAAAAACAAAA
TCTCCACAACAAAATAACCCTCTGATTTATAAACTCTTATAGTCAAAGAGGGAAAACAAAGGTTGAGAGATTAAGTGGCTGCTTCTGAGA
AATAATGTCTCAAGGACTAAAGGAGCAATTCAATAGGTTTAGACATTGTAGCTCTCTACATCTTGAATTGGAAGCTGGAATAAAGAGCCC
CCACCCCCCCCCCCACCCTCATCGAATGCTGCTTACTTTGTCAAAAGACTGGCTATGACCAAGGTGAGGATATTTCTGGAAAACTGGGCA
AAAAGGGAAAGCCCACAGTATTCTTCCTTGGCAGTCAACCACAGGTTTACTTTACAATGATGTATTAAAAACTTGCAGCTTGAAAAATGG
AATGCAAATAAAAGGTTCTCTTTGGGTTTGTCTTAATGGAGTTAAACTGGAGCAGCCTATAAAACATTTTTAGGGTGATGTCCTCTGGGT
CCTTCTGTTCTGCACACCCACTCAGTCTTCTCTCCCAGCCCCTTGACTGCACACACCCCTCTTTGCCTGAAGATCTCCTGACTTGTCGCC

>In-frame_ENST00000455089_ENST00000419735_TCGA-VQ-AA6I_EGFR_chr7_55269475_+_ATXN7L1_chr7_105251050_length(amino acids)=1046AA_start in transcript=257_stop in transcript=3397
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVL
IALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQGQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRG
KSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADS
YEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFL
LIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRG
ENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHY
IDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVR
KRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYV
MASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITD
FGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYM
IMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLL

--------------------------------------------------------------
>In-frame_ENST00000455089_ENST00000477775_TCGA-VQ-AA6I_EGFR_chr7_55269475_+_ATXN7L1_chr7_105251050_length(transcript)=3482nt_BP=3284nt
GTCCGGGCAGCCCCCGGCGCAGCGCGGCCGCAGCAGCCTCCGCCCCCCGCACGGTGTGAGCGCCCGACGCGGCCGAGGCGGCCGGAGTCC
CGAGCTAGCCCCGGCGGCCGCCGCCGCCCAGACCGGACGACAGGCCACCTCGTCGGCGTCCGCCCGAGTCCCCGCCTCGCCGCCAACGCC
ACAACCACCGCGCACGGCCCCCTGACTCCGTCCAGTATTGATCGGGAGAGCCGGAGCGAGCTCTTCGGGGAGCAGCGATGCGACCCTCCG
GGACGGCCGGGGCAGCGCTCCTGGCGCTGCTGGCTGCGCTCTGCCCGGCGAGTCGGGCTCTGGAGGAAAAGAAAGTTTGCCAAGGCACGA
GTAACAAGCTCACGCAGTTGGGCACTTTTGAAGATCATTTTCTCAGCCTCCAGAGGATGTTCAATAACTGTGAGGTGGTCCTTGGGAATT
TGGAAATTACCTATGTGCAGAGGAATTATGATCTTTCCTTCTTAAAGACCATCCAGGAGGTGGCTGGTTATGTCCTCATTGCCCTCAACA
CAGTGGAGCGAATTCCTTTGGAAAACCTGCAGATCATCAGAGGAAATATGTACTACGAAAATTCCTATGCCTTAGCAGTCTTATCTAACT
ATGATGCAAATAAAACCGGACTGAAGGAGCTGCCCATGAGAAATTTACAGGGCCAAAAGTGTGATCCAAGCTGTCCCAATGGGAGCTGCT
GGGGTGCAGGAGAGGAGAACTGCCAGAAACTGACCAAAATCATCTGTGCCCAGCAGTGCTCCGGGCGCTGCCGTGGCAAGTCCCCCAGTG
ACTGCTGCCACAACCAGTGTGCTGCAGGCTGCACAGGCCCCCGGGAGAGCGACTGCCTGGTCTGCCGCAAATTCCGAGACGAAGCCACGT
GCAAGGACACCTGCCCCCCACTCATGCTCTACAACCCCACCACGTACCAGATGGATGTGAACCCCGAGGGCAAATACAGCTTTGGTGCCA
CCTGCGTGAAGAAGTGTCCCCGTAATTATGTGGTGACAGATCACGGCTCGTGCGTCCGAGCCTGTGGGGCCGACAGCTATGAGATGGAGG
AAGACGGCGTCCGCAAGTGTAAGAAGTGCGAAGGGCCTTGCCGCAAAGTGTGTAACGGAATAGGTATTGGTGAATTTAAAGACTCACTCT
CCATAAATGCTACGAATATTAAACACTTCAAAAACTGCACCTCCATCAGTGGCGATCTCCACATCCTGCCGGTGGCATTTAGGGGTGACT
CCTTCACACATACTCCTCCTCTGGATCCACAGGAACTGGATATTCTGAAAACCGTAAAGGAAATCACAGGGTTTTTGCTGATTCAGGCTT
GGCCTGAAAACAGGACGGACCTCCATGCCTTTGAGAACCTAGAAATCATACGCGGCAGGACCAAGCAACATGGTCAGTTTTCTCTTGCAG
TCGTCAGCCTGAACATAACATCCTTGGGATTACGCTCCCTCAAGGAGATAAGTGATGGAGATGTGATAATTTCAGGAAACAAAAATTTGT
GCTATGCAAATACAATAAACTGGAAAAAACTGTTTGGGACCTCCGGTCAGAAAACCAAAATTATAAGCAACAGAGGTGAAAACAGCTGCA
AGGCCACAGGCCAGGTCTGCCATGCCTTGTGCTCCCCCGAGGGCTGCTGGGGCCCGGAGCCCAGGGACTGCGTCTCTTGCCGGAATGTCA
GCCGAGGCAGGGAATGCGTGGACAAGTGCAACCTTCTGGAGGGTGAGCCAAGGGAGTTTGTGGAGAACTCTGAGTGCATACAGTGCCACC
CAGAGTGCCTGCCTCAGGCCATGAACATCACCTGCACAGGACGGGGACCAGACAACTGTATCCAGTGTGCCCACTACATTGACGGCCCCC
ACTGCGTCAAGACCTGCCCGGCAGGAGTCATGGGAGAAAACAACACCCTGGTCTGGAAGTACGCAGACGCCGGCCATGTGTGCCACCTGT
GCCATCCAAACTGCACCTACGGATGCACTGGGCCAGGTCTTGAAGGCTGTCCAACGAATGGGCCTAAGATCCCGTCCATCGCCACTGGGA
TGGTGGGGGCCCTCCTCTTGCTGCTGGTGGTGGCCCTGGGGATCGGCCTCTTCATGCGAAGGCGCCACATCGTTCGGAAGCGCACGCTGC
GGAGGCTGCTGCAGGAGAGGGAGCTTGTGGAGCCTCTTACACCCAGTGGAGAAGCTCCCAACCAAGCTCTCTTGAGGATCTTGAAGGAAA
CTGAATTCAAAAAGATCAAAGTGCTGGGCTCCGGTGCGTTCGGCACGGTGTATAAGGGACTCTGGATCCCAGAAGGTGAGAAAGTTAAAA
TTCCCGTCGCTATCAAGGAATTAAGAGAAGCAACATCTCCGAAAGCCAACAAGGAAATCCTCGATGAAGCCTACGTGATGGCCAGCGTGG
ACAACCCCCACGTGTGCCGCCTGCTGGGCATCTGCCTCACCTCCACCGTGCAGCTCATCACGCAGCTCATGCCCTTCGGCTGCCTCCTGG
ACTATGTCCGGGAACACAAAGACAATATTGGCTCCCAGTACCTGCTCAACTGGTGTGTGCAGATCGCAAAGGGCATGAACTACTTGGAGG
ACCGTCGCTTGGTGCACCGCGACCTGGCAGCCAGGAACGTACTGGTGAAAACACCGCAGCATGTCAAGATCACAGATTTTGGGCTGGCCA
AACTGCTGGGTGCGGAAGAGAAAGAATACCATGCAGAAGGAGGCAAAGTGCCTATCAAGTGGATGGCATTGGAATCAATTTTACACAGAA
TCTATACCCACCAGAGTGATGTCTGGAGCTACGGGGTGACTGTTTGGGAGTTGATGACCTTTGGATCCAAGCCATATGACGGAATCCCTG
CCAGCGAGATCTCCTCCATCCTGGAGAAAGGAGAACGCCTCCCTCAGCCACCCATATGTACCATCGATGTCTACATGATCATGGTCAAGT
GCTGGATGATAGACGCAGATAGTCGCCCAAAGTTCCGTGAGTTGATCATCGAATTCTCCAAAATGGCCCGAGACCCCCAGCGCTACCTTG
TCATTCAGGGGGATGAAAGAATGCATTTGCCAAGTCCTACAGACTCCAACTTCTACCGTGCCCTGATGGATGAAGAAGACATGGACGACG
TGGTGGATGCCGACGAGTACCTCATCCCACAGCAGGGCTTCTTCAGCAGCCCCTCCACGTCACGGACTCCCCTCCTGAGCTCTCTGAGTG
CAACCAGCAACAATTCCACCGTGGCTTGCATTGATAGAAATGGGGTTGGGAAAAATAGCAGCCTAGCTTTGTCACAATCCAGTCCTTCAA
GTATATCCAGCCCAGGACACAGCCGACAGAAGAACACAAACAGAACGGGCAGGATAAGGACTCTTCCATAACAAGACTATGAAGCCACTT

>In-frame_ENST00000455089_ENST00000477775_TCGA-VQ-AA6I_EGFR_chr7_55269475_+_ATXN7L1_chr7_105251050_length(amino acids)=1047AA_start in transcript=257_stop in transcript=3400
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVL
IALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQGQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRG
KSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADS
YEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFL
LIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRG
ENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHY
IDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVR
KRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYV
MASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITD
FGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYM
IMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLL

--------------------------------------------------------------
>In-frame_ENST00000275493_ENST00000419735_TCGA-VQ-AA6I_EGFR_chr7_55269475_+_ATXN7L1_chr7_105251050_length(transcript)=6238nt_BP=3339nt
GCCGGAGTCCCGAGCTAGCCCCGGCGGCCGCCGCCGCCCAGACCGGACGACAGGCCACCTCGTCGGCGTCCGCCCGAGTCCCCGCCTCGC
CGCCAACGCCACAACCACCGCGCACGGCCCCCTGACTCCGTCCAGTATTGATCGGGAGAGCCGGAGCGAGCTCTTCGGGGAGCAGCGATG
CGACCCTCCGGGACGGCCGGGGCAGCGCTCCTGGCGCTGCTGGCTGCGCTCTGCCCGGCGAGTCGGGCTCTGGAGGAAAAGAAAGTTTGC
CAAGGCACGAGTAACAAGCTCACGCAGTTGGGCACTTTTGAAGATCATTTTCTCAGCCTCCAGAGGATGTTCAATAACTGTGAGGTGGTC
CTTGGGAATTTGGAAATTACCTATGTGCAGAGGAATTATGATCTTTCCTTCTTAAAGACCATCCAGGAGGTGGCTGGTTATGTCCTCATT
GCCCTCAACACAGTGGAGCGAATTCCTTTGGAAAACCTGCAGATCATCAGAGGAAATATGTACTACGAAAATTCCTATGCCTTAGCAGTC
TTATCTAACTATGATGCAAATAAAACCGGACTGAAGGAGCTGCCCATGAGAAATTTACAGGAAATCCTGCATGGCGCCGTGCGGTTCAGC
AACAACCCTGCCCTGTGCAACGTGGAGAGCATCCAGTGGCGGGACATAGTCAGCAGTGACTTTCTCAGCAACATGTCGATGGACTTCCAG
AACCACCTGGGCAGCTGCCAAAAGTGTGATCCAAGCTGTCCCAATGGGAGCTGCTGGGGTGCAGGAGAGGAGAACTGCCAGAAACTGACC
AAAATCATCTGTGCCCAGCAGTGCTCCGGGCGCTGCCGTGGCAAGTCCCCCAGTGACTGCTGCCACAACCAGTGTGCTGCAGGCTGCACA
GGCCCCCGGGAGAGCGACTGCCTGGTCTGCCGCAAATTCCGAGACGAAGCCACGTGCAAGGACACCTGCCCCCCACTCATGCTCTACAAC
CCCACCACGTACCAGATGGATGTGAACCCCGAGGGCAAATACAGCTTTGGTGCCACCTGCGTGAAGAAGTGTCCCCGTAATTATGTGGTG
ACAGATCACGGCTCGTGCGTCCGAGCCTGTGGGGCCGACAGCTATGAGATGGAGGAAGACGGCGTCCGCAAGTGTAAGAAGTGCGAAGGG
CCTTGCCGCAAAGTGTGTAACGGAATAGGTATTGGTGAATTTAAAGACTCACTCTCCATAAATGCTACGAATATTAAACACTTCAAAAAC
TGCACCTCCATCAGTGGCGATCTCCACATCCTGCCGGTGGCATTTAGGGGTGACTCCTTCACACATACTCCTCCTCTGGATCCACAGGAA
CTGGATATTCTGAAAACCGTAAAGGAAATCACAGGGTTTTTGCTGATTCAGGCTTGGCCTGAAAACAGGACGGACCTCCATGCCTTTGAG
AACCTAGAAATCATACGCGGCAGGACCAAGCAACATGGTCAGTTTTCTCTTGCAGTCGTCAGCCTGAACATAACATCCTTGGGATTACGC
TCCCTCAAGGAGATAAGTGATGGAGATGTGATAATTTCAGGAAACAAAAATTTGTGCTATGCAAATACAATAAACTGGAAAAAACTGTTT
GGGACCTCCGGTCAGAAAACCAAAATTATAAGCAACAGAGGTGAAAACAGCTGCAAGGCCACAGGCCAGGTCTGCCATGCCTTGTGCTCC
CCCGAGGGCTGCTGGGGCCCGGAGCCCAGGGACTGCGTCTCTTGCCGGAATGTCAGCCGAGGCAGGGAATGCGTGGACAAGTGCAACCTT
CTGGAGGGTGAGCCAAGGGAGTTTGTGGAGAACTCTGAGTGCATACAGTGCCACCCAGAGTGCCTGCCTCAGGCCATGAACATCACCTGC
ACAGGACGGGGACCAGACAACTGTATCCAGTGTGCCCACTACATTGACGGCCCCCACTGCGTCAAGACCTGCCCGGCAGGAGTCATGGGA
GAAAACAACACCCTGGTCTGGAAGTACGCAGACGCCGGCCATGTGTGCCACCTGTGCCATCCAAACTGCACCTACGGATGCACTGGGCCA
GGTCTTGAAGGCTGTCCAACGAATGGGCCTAAGATCCCGTCCATCGCCACTGGGATGGTGGGGGCCCTCCTCTTGCTGCTGGTGGTGGCC
CTGGGGATCGGCCTCTTCATGCGAAGGCGCCACATCGTTCGGAAGCGCACGCTGCGGAGGCTGCTGCAGGAGAGGGAGCTTGTGGAGCCT
CTTACACCCAGTGGAGAAGCTCCCAACCAAGCTCTCTTGAGGATCTTGAAGGAAACTGAATTCAAAAAGATCAAAGTGCTGGGCTCCGGT
GCGTTCGGCACGGTGTATAAGGGACTCTGGATCCCAGAAGGTGAGAAAGTTAAAATTCCCGTCGCTATCAAGGAATTAAGAGAAGCAACA
TCTCCGAAAGCCAACAAGGAAATCCTCGATGAAGCCTACGTGATGGCCAGCGTGGACAACCCCCACGTGTGCCGCCTGCTGGGCATCTGC
CTCACCTCCACCGTGCAGCTCATCACGCAGCTCATGCCCTTCGGCTGCCTCCTGGACTATGTCCGGGAACACAAAGACAATATTGGCTCC
CAGTACCTGCTCAACTGGTGTGTGCAGATCGCAAAGGGCATGAACTACTTGGAGGACCGTCGCTTGGTGCACCGCGACCTGGCAGCCAGG
AACGTACTGGTGAAAACACCGCAGCATGTCAAGATCACAGATTTTGGGCTGGCCAAACTGCTGGGTGCGGAAGAGAAAGAATACCATGCA
GAAGGAGGCAAAGTGCCTATCAAGTGGATGGCATTGGAATCAATTTTACACAGAATCTATACCCACCAGAGTGATGTCTGGAGCTACGGG
GTGACTGTTTGGGAGTTGATGACCTTTGGATCCAAGCCATATGACGGAATCCCTGCCAGCGAGATCTCCTCCATCCTGGAGAAAGGAGAA
CGCCTCCCTCAGCCACCCATATGTACCATCGATGTCTACATGATCATGGTCAAGTGCTGGATGATAGACGCAGATAGTCGCCCAAAGTTC
CGTGAGTTGATCATCGAATTCTCCAAAATGGCCCGAGACCCCCAGCGCTACCTTGTCATTCAGGGGGATGAAAGAATGCATTTGCCAAGT
CCTACAGACTCCAACTTCTACCGTGCCCTGATGGATGAAGAAGACATGGACGACGTGGTGGATGCCGACGAGTACCTCATCCCACAGCAG
GGCTTCTTCAGCAGCCCCTCCACGTCACGGACTCCCCTCCTGAGCTCTCTGAGTGCAACCAGCAACAATTCCACCGTGGCTTGCATTGAT
AGAAATGGGGTTGGGAAAAATAGCAGCCTAGCTTTGTCACAATCCAGTCCTTCAAGTATATCCAGCCCAGGACACAGCCGACAGAACACA
AACAGAACGGGCAGGATAAGGACTCTTCCATAACAAGACTATGAAGCCACTTCCACATCAATTCCAGGCCACCTAATCCCATCCGAGGAG
GCCATGGGGAGGAGGAGGGAGGGGAGTGGGCTGGGGGGAGAGTCTGTTTTCTGTGCACTCCCTGTGACTCTGGCCTTTCTTCTTCTTTTT
TTAATTGACCAATTTTTAGTTAAAAAGGCAAAAGAAGGTGAATTTGAGATTTACAGAAAACAGTTCCAGTGTTTGGTTTCCGCTGTCTTT
CCTTTCATTTGCCATGTTTTTACATTCTTCCAAATTTGGGGTCACTCCCCTAGCTCCTGATGCTGCTACTGTACCATCCTTTTGCTCCAG
CCATGAGAGCAGACATTGCAGAATGTTGGTTCCAGGTTGGCATGCTCTGAAGCTCTTGAACTGTAGCACAGGCAGAGCCCTTTTTCTTCC
TGTCATCTCCACCCGATTCCTTCCATCCCTACGTCTACCACTCTCTGGGTCCTCACTGGTCTTCAAAGGACCTGGCTCTCATAGGATCCC
CTCAGGATTGTGTGCAGGGAGAGGGGGCTTTGCTGGGGAGGAGCTGGGAGTGGAGAGTTGGAGGGTGGGTGGGGTTCCCTCATCCAGTTT
CCACAGCCCACCATGGCTGGAGCCAAATGCTAGAAGCGAGATTGAGAACAGTGGCCGTTTAGTGATGTGGTTTACCTAATACCACTGTCC
AGCTGTGCAGCTCAGAAAGGATAAACCAGTCAGGGACAGGGGCCAGAACAGGTTTGGGAAGGTGGCAGCAAGCAGAGCATGGTGGGTAGG
AGATGATCCCTAAAAAAACTGGAGACTGTGGTGGTCTGAGCTGGTCAGGAATCTGCAGAATCCCTTCCAGGAATCAGTGTGCCAGTGCCC
ACAGCAGGGTGAGCTAGGAGGGAGAAATCCCAGGAAAAAGGTCGTGAGAACCCAGAAAGCCACTCCATGAGGAGGCACGGTGACCACAGC
TGCTAAAGGTTCTTAGGCTGCCTTCCTGGGCTAGGAAGAGCCCCCCAGGGAGAGCTTCCACAAAAGGGTATGTGTCAAACCTTTTGTCAG
AATAAATAATAGCATTTCCCACCCACCCCCATGCCCTGGGCCACAGGGACTTGGTGGGATCAGCACACCCATGGATCAGCTTTTGCTGTC
TTAGAGACAGCCATCCCCATGAAGGAATGGTAAGGACAGCCACTGCTCAGTGAAGAACAGCCATTTGGAAGAGCCACGCTGGAGCCCTGC
AGCCATAGAACTATTCACACTGGAGTTTTAAAAGAAACAGCAATACCATAAGCTCTAGTAGGGAATCATAATCAGGAAAGGAATTCACAA
CATAAAATAGGTGTTCTGTGCTATTAATCATGTAACTTTGTATATGATGTATAGCAAAGATACTGGGAGGTTTTGTTTCATCCTTAAATC
AGAAATGAATGCTAGTTTCATAGCTGGGCAGAACCCTCATCCCCACCCCAAAGTTTTCCTTTTCTTTCCCGTTCCCCCAACCCAAAGATC
AGACTACTGTTAAGTTTCACCACACAATTGGAATTGCAAAGACGGGAGGCAAATGGAGTGATTTTCATCAATGGAATTGCACTGACAGTG
AGTGTTTCTTATAGGATTACTAAATTTTTTAATATAAAATGATTTGTTTAAAAATCAGGAGTTGATATTAAGTACCAGGACATTAGTTCG
GATGATTTCATTTTTATTTCTACAGTGTTAAAAGTGCACTTATATGCTGGTTTATTTACGTCTTGGGAAAAGAGACTGCAAATTGAAGGG
ATGATTGTTACTTTTTCTTTTTTTAAAAAAAAAAGGTTAAGGAGATTTTAAGACTTATAAATGTTTAAGAAATTATAAACAAGGTTAGAC
CCTTTGAAAAAAAGTTTAGAAGATATTCTTAAAGTAAATTTTTATAGTGTTAATTTTGTAATAATTTATGTTTTACTATATTACAGAGCT
AACTGACCAGAATAGTTTCAGAAACAATATGAAACTTAGGAAAGTTTAAGCAATGTTTATATTTTTAAAATGTTCTTTGAATTATGTTTT
TATTGTACATTTCTTCAGACTGAAAAGTATGTACATATCTTTGTTATTTTTGCACAATTTTGTCTTGTTCGGTTTCAGAGGTCTGTTGTT
TTTTATAATTTATTTTGAGTTGTAAAACTTGCAGGAGTAAAAACAAAAAACAAAATCTCCACAACAAAATAACCCTCTGATTTATAAACT
CTTATAGTCAAAGAGGGAAAACAAAGGTTGAGAGATTAAGTGGCTGCTTCTGAGAAATAATGTCTCAAGGACTAAAGGAGCAATTCAATA
GGTTTAGACATTGTAGCTCTCTACATCTTGAATTGGAAGCTGGAATAAAGAGCCCCCACCCCCCCCCCCACCCTCATCGAATGCTGCTTA
CTTTGTCAAAAGACTGGCTATGACCAAGGTGAGGATATTTCTGGAAAACTGGGCAAAAAGGGAAAGCCCACAGTATTCTTCCTTGGCAGT
CAACCACAGGTTTACTTTACAATGATGTATTAAAAACTTGCAGCTTGAAAAATGGAATGCAAATAAAAGGTTCTCTTTGGGTTTGTCTTA
ATGGAGTTAAACTGGAGCAGCCTATAAAACATTTTTAGGGTGATGTCCTCTGGGTCCTTCTGTTCTGCACACCCACTCAGTCTTCTCTCC
CAGCCCCTTGACTGCACACACCCCTCTTTGCCTGAAGATCTCCTGACTTGTCGCCAGCCATAGAGGCTCGAAAGCTCTGGTTGTGAAGCA

>In-frame_ENST00000275493_ENST00000419735_TCGA-VQ-AA6I_EGFR_chr7_55269475_+_ATXN7L1_chr7_105251050_length(amino acids)=1091AA_start in transcript=177_stop in transcript=3452
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVL
IALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLY
NPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGL
RSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTG
PGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIG
SQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLP
SPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGVGKNSSLALSQSSPSSISSPGHSRQN

--------------------------------------------------------------
>In-frame_ENST00000275493_ENST00000477775_TCGA-VQ-AA6I_EGFR_chr7_55269475_+_ATXN7L1_chr7_105251050_length(transcript)=3537nt_BP=3339nt
GCCGGAGTCCCGAGCTAGCCCCGGCGGCCGCCGCCGCCCAGACCGGACGACAGGCCACCTCGTCGGCGTCCGCCCGAGTCCCCGCCTCGC
CGCCAACGCCACAACCACCGCGCACGGCCCCCTGACTCCGTCCAGTATTGATCGGGAGAGCCGGAGCGAGCTCTTCGGGGAGCAGCGATG
CGACCCTCCGGGACGGCCGGGGCAGCGCTCCTGGCGCTGCTGGCTGCGCTCTGCCCGGCGAGTCGGGCTCTGGAGGAAAAGAAAGTTTGC
CAAGGCACGAGTAACAAGCTCACGCAGTTGGGCACTTTTGAAGATCATTTTCTCAGCCTCCAGAGGATGTTCAATAACTGTGAGGTGGTC
CTTGGGAATTTGGAAATTACCTATGTGCAGAGGAATTATGATCTTTCCTTCTTAAAGACCATCCAGGAGGTGGCTGGTTATGTCCTCATT
GCCCTCAACACAGTGGAGCGAATTCCTTTGGAAAACCTGCAGATCATCAGAGGAAATATGTACTACGAAAATTCCTATGCCTTAGCAGTC
TTATCTAACTATGATGCAAATAAAACCGGACTGAAGGAGCTGCCCATGAGAAATTTACAGGAAATCCTGCATGGCGCCGTGCGGTTCAGC
AACAACCCTGCCCTGTGCAACGTGGAGAGCATCCAGTGGCGGGACATAGTCAGCAGTGACTTTCTCAGCAACATGTCGATGGACTTCCAG
AACCACCTGGGCAGCTGCCAAAAGTGTGATCCAAGCTGTCCCAATGGGAGCTGCTGGGGTGCAGGAGAGGAGAACTGCCAGAAACTGACC
AAAATCATCTGTGCCCAGCAGTGCTCCGGGCGCTGCCGTGGCAAGTCCCCCAGTGACTGCTGCCACAACCAGTGTGCTGCAGGCTGCACA
GGCCCCCGGGAGAGCGACTGCCTGGTCTGCCGCAAATTCCGAGACGAAGCCACGTGCAAGGACACCTGCCCCCCACTCATGCTCTACAAC
CCCACCACGTACCAGATGGATGTGAACCCCGAGGGCAAATACAGCTTTGGTGCCACCTGCGTGAAGAAGTGTCCCCGTAATTATGTGGTG
ACAGATCACGGCTCGTGCGTCCGAGCCTGTGGGGCCGACAGCTATGAGATGGAGGAAGACGGCGTCCGCAAGTGTAAGAAGTGCGAAGGG
CCTTGCCGCAAAGTGTGTAACGGAATAGGTATTGGTGAATTTAAAGACTCACTCTCCATAAATGCTACGAATATTAAACACTTCAAAAAC
TGCACCTCCATCAGTGGCGATCTCCACATCCTGCCGGTGGCATTTAGGGGTGACTCCTTCACACATACTCCTCCTCTGGATCCACAGGAA
CTGGATATTCTGAAAACCGTAAAGGAAATCACAGGGTTTTTGCTGATTCAGGCTTGGCCTGAAAACAGGACGGACCTCCATGCCTTTGAG
AACCTAGAAATCATACGCGGCAGGACCAAGCAACATGGTCAGTTTTCTCTTGCAGTCGTCAGCCTGAACATAACATCCTTGGGATTACGC
TCCCTCAAGGAGATAAGTGATGGAGATGTGATAATTTCAGGAAACAAAAATTTGTGCTATGCAAATACAATAAACTGGAAAAAACTGTTT
GGGACCTCCGGTCAGAAAACCAAAATTATAAGCAACAGAGGTGAAAACAGCTGCAAGGCCACAGGCCAGGTCTGCCATGCCTTGTGCTCC
CCCGAGGGCTGCTGGGGCCCGGAGCCCAGGGACTGCGTCTCTTGCCGGAATGTCAGCCGAGGCAGGGAATGCGTGGACAAGTGCAACCTT
CTGGAGGGTGAGCCAAGGGAGTTTGTGGAGAACTCTGAGTGCATACAGTGCCACCCAGAGTGCCTGCCTCAGGCCATGAACATCACCTGC
ACAGGACGGGGACCAGACAACTGTATCCAGTGTGCCCACTACATTGACGGCCCCCACTGCGTCAAGACCTGCCCGGCAGGAGTCATGGGA
GAAAACAACACCCTGGTCTGGAAGTACGCAGACGCCGGCCATGTGTGCCACCTGTGCCATCCAAACTGCACCTACGGATGCACTGGGCCA
GGTCTTGAAGGCTGTCCAACGAATGGGCCTAAGATCCCGTCCATCGCCACTGGGATGGTGGGGGCCCTCCTCTTGCTGCTGGTGGTGGCC
CTGGGGATCGGCCTCTTCATGCGAAGGCGCCACATCGTTCGGAAGCGCACGCTGCGGAGGCTGCTGCAGGAGAGGGAGCTTGTGGAGCCT
CTTACACCCAGTGGAGAAGCTCCCAACCAAGCTCTCTTGAGGATCTTGAAGGAAACTGAATTCAAAAAGATCAAAGTGCTGGGCTCCGGT
GCGTTCGGCACGGTGTATAAGGGACTCTGGATCCCAGAAGGTGAGAAAGTTAAAATTCCCGTCGCTATCAAGGAATTAAGAGAAGCAACA
TCTCCGAAAGCCAACAAGGAAATCCTCGATGAAGCCTACGTGATGGCCAGCGTGGACAACCCCCACGTGTGCCGCCTGCTGGGCATCTGC
CTCACCTCCACCGTGCAGCTCATCACGCAGCTCATGCCCTTCGGCTGCCTCCTGGACTATGTCCGGGAACACAAAGACAATATTGGCTCC
CAGTACCTGCTCAACTGGTGTGTGCAGATCGCAAAGGGCATGAACTACTTGGAGGACCGTCGCTTGGTGCACCGCGACCTGGCAGCCAGG
AACGTACTGGTGAAAACACCGCAGCATGTCAAGATCACAGATTTTGGGCTGGCCAAACTGCTGGGTGCGGAAGAGAAAGAATACCATGCA
GAAGGAGGCAAAGTGCCTATCAAGTGGATGGCATTGGAATCAATTTTACACAGAATCTATACCCACCAGAGTGATGTCTGGAGCTACGGG
GTGACTGTTTGGGAGTTGATGACCTTTGGATCCAAGCCATATGACGGAATCCCTGCCAGCGAGATCTCCTCCATCCTGGAGAAAGGAGAA
CGCCTCCCTCAGCCACCCATATGTACCATCGATGTCTACATGATCATGGTCAAGTGCTGGATGATAGACGCAGATAGTCGCCCAAAGTTC
CGTGAGTTGATCATCGAATTCTCCAAAATGGCCCGAGACCCCCAGCGCTACCTTGTCATTCAGGGGGATGAAAGAATGCATTTGCCAAGT
CCTACAGACTCCAACTTCTACCGTGCCCTGATGGATGAAGAAGACATGGACGACGTGGTGGATGCCGACGAGTACCTCATCCCACAGCAG
GGCTTCTTCAGCAGCCCCTCCACGTCACGGACTCCCCTCCTGAGCTCTCTGAGTGCAACCAGCAACAATTCCACCGTGGCTTGCATTGAT
AGAAATGGGGTTGGGAAAAATAGCAGCCTAGCTTTGTCACAATCCAGTCCTTCAAGTATATCCAGCCCAGGACACAGCCGACAGAAGAAC
ACAAACAGAACGGGCAGGATAAGGACTCTTCCATAACAAGACTATGAAGCCACTTCCACATCAATTCCAGGCCACCTAATCCCATCCGAG

>In-frame_ENST00000275493_ENST00000477775_TCGA-VQ-AA6I_EGFR_chr7_55269475_+_ATXN7L1_chr7_105251050_length(amino acids)=1092AA_start in transcript=177_stop in transcript=3455
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVL
IALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLY
NPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGL
RSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTG
PGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIG
SQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLP
SPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGVGKNSSLALSQSSPSSISSPGHSRQK

--------------------------------------------------------------
>In-frame_ENST00000454757_ENST00000419735_TCGA-VQ-AA6I_EGFR_chr7_55269475_+_ATXN7L1_chr7_105251050_length(transcript)=6085nt_BP=3186nt
ACTGGACTTCAGAACAAGAGGGAGCTCTGGGCTGCTGGCTGGTTGTGCATTTGCTGTGGGTTCCCTCCGGCAGGCGACCTCTCCGCGCTG
AGAAGGTTATCCGGATAACCAATTTGCCAAGGCACGAGTAACAAGCTCACGCAGTTGGGCACTTTTGAAGATCATTTTCTCAGCCTCCAG
AGGATGTTCAATAACTGTGAGGTGGTCCTTGGGAATTTGGAAATTACCTATGTGCAGAGGAATTATGATCTTTCCTTCTTAAAGACCATC
CAGGAGGTGGCTGGTTATGTCCTCATTGCCCTCAACACAGTGGAGCGAATTCCTTTGGAAAACCTGCAGATCATCAGAGGAAATATGTAC
TACGAAAATTCCTATGCCTTAGCAGTCTTATCTAACTATGATGCAAATAAAACCGGACTGAAGGAGCTGCCCATGAGAAATTTACAGGAA
ATCCTGCATGGCGCCGTGCGGTTCAGCAACAACCCTGCCCTGTGCAACGTGGAGAGCATCCAGTGGCGGGACATAGTCAGCAGTGACTTT
CTCAGCAACATGTCGATGGACTTCCAGAACCACCTGGGCAGCTGCCAAAAGTGTGATCCAAGCTGTCCCAATGGGAGCTGCTGGGGTGCA
GGAGAGGAGAACTGCCAGAAACTGACCAAAATCATCTGTGCCCAGCAGTGCTCCGGGCGCTGCCGTGGCAAGTCCCCCAGTGACTGCTGC
CACAACCAGTGTGCTGCAGGCTGCACAGGCCCCCGGGAGAGCGACTGCCTGGTCTGCCGCAAATTCCGAGACGAAGCCACGTGCAAGGAC
ACCTGCCCCCCACTCATGCTCTACAACCCCACCACGTACCAGATGGATGTGAACCCCGAGGGCAAATACAGCTTTGGTGCCACCTGCGTG
AAGAAGTGTCCCCGTAATTATGTGGTGACAGATCACGGCTCGTGCGTCCGAGCCTGTGGGGCCGACAGCTATGAGATGGAGGAAGACGGC
GTCCGCAAGTGTAAGAAGTGCGAAGGGCCTTGCCGCAAAGTGTGTAACGGAATAGGTATTGGTGAATTTAAAGACTCACTCTCCATAAAT
GCTACGAATATTAAACACTTCAAAAACTGCACCTCCATCAGTGGCGATCTCCACATCCTGCCGGTGGCATTTAGGGGTGACTCCTTCACA
CATACTCCTCCTCTGGATCCACAGGAACTGGATATTCTGAAAACCGTAAAGGAAATCACAGGGTTTTTGCTGATTCAGGCTTGGCCTGAA
AACAGGACGGACCTCCATGCCTTTGAGAACCTAGAAATCATACGCGGCAGGACCAAGCAACATGGTCAGTTTTCTCTTGCAGTCGTCAGC
CTGAACATAACATCCTTGGGATTACGCTCCCTCAAGGAGATAAGTGATGGAGATGTGATAATTTCAGGAAACAAAAATTTGTGCTATGCA
AATACAATAAACTGGAAAAAACTGTTTGGGACCTCCGGTCAGAAAACCAAAATTATAAGCAACAGAGGTGAAAACAGCTGCAAGGCCACA
GGCCAGGTCTGCCATGCCTTGTGCTCCCCCGAGGGCTGCTGGGGCCCGGAGCCCAGGGACTGCGTCTCTTGCCGGAATGTCAGCCGAGGC
AGGGAATGCGTGGACAAGTGCAACCTTCTGGAGGGTGAGCCAAGGGAGTTTGTGGAGAACTCTGAGTGCATACAGTGCCACCCAGAGTGC
CTGCCTCAGGCCATGAACATCACCTGCACAGGACGGGGACCAGACAACTGTATCCAGTGTGCCCACTACATTGACGGCCCCCACTGCGTC
AAGACCTGCCCGGCAGGAGTCATGGGAGAAAACAACACCCTGGTCTGGAAGTACGCAGACGCCGGCCATGTGTGCCACCTGTGCCATCCA
AACTGCACCTACGGATGCACTGGGCCAGGTCTTGAAGGCTGTCCAACGAATGGGCCTAAGATCCCGTCCATCGCCACTGGGATGGTGGGG
GCCCTCCTCTTGCTGCTGGTGGTGGCCCTGGGGATCGGCCTCTTCATGCGAAGGCGCCACATCGTTCGGAAGCGCACGCTGCGGAGGCTG
CTGCAGGAGAGGGAGCTTGTGGAGCCTCTTACACCCAGTGGAGAAGCTCCCAACCAAGCTCTCTTGAGGATCTTGAAGGAAACTGAATTC
AAAAAGATCAAAGTGCTGGGCTCCGGTGCGTTCGGCACGGTGTATAAGGGACTCTGGATCCCAGAAGGTGAGAAAGTTAAAATTCCCGTC
GCTATCAAGGAATTAAGAGAAGCAACATCTCCGAAAGCCAACAAGGAAATCCTCGATGAAGCCTACGTGATGGCCAGCGTGGACAACCCC
CACGTGTGCCGCCTGCTGGGCATCTGCCTCACCTCCACCGTGCAGCTCATCACGCAGCTCATGCCCTTCGGCTGCCTCCTGGACTATGTC
CGGGAACACAAAGACAATATTGGCTCCCAGTACCTGCTCAACTGGTGTGTGCAGATCGCAAAGGGCATGAACTACTTGGAGGACCGTCGC
TTGGTGCACCGCGACCTGGCAGCCAGGAACGTACTGGTGAAAACACCGCAGCATGTCAAGATCACAGATTTTGGGCTGGCCAAACTGCTG
GGTGCGGAAGAGAAAGAATACCATGCAGAAGGAGGCAAAGTGCCTATCAAGTGGATGGCATTGGAATCAATTTTACACAGAATCTATACC
CACCAGAGTGATGTCTGGAGCTACGGGGTGACTGTTTGGGAGTTGATGACCTTTGGATCCAAGCCATATGACGGAATCCCTGCCAGCGAG
ATCTCCTCCATCCTGGAGAAAGGAGAACGCCTCCCTCAGCCACCCATATGTACCATCGATGTCTACATGATCATGGTCAAGTGCTGGATG
ATAGACGCAGATAGTCGCCCAAAGTTCCGTGAGTTGATCATCGAATTCTCCAAAATGGCCCGAGACCCCCAGCGCTACCTTGTCATTCAG
GGGGATGAAAGAATGCATTTGCCAAGTCCTACAGACTCCAACTTCTACCGTGCCCTGATGGATGAAGAAGACATGGACGACGTGGTGGAT
GCCGACGAGTACCTCATCCCACAGCAGGGCTTCTTCAGCAGCCCCTCCACGTCACGGACTCCCCTCCTGAGCTCTCTGAGTGCAACCAGC
AACAATTCCACCGTGGCTTGCATTGATAGAAATGGGGTTGGGAAAAATAGCAGCCTAGCTTTGTCACAATCCAGTCCTTCAAGTATATCC
AGCCCAGGACACAGCCGACAGAACACAAACAGAACGGGCAGGATAAGGACTCTTCCATAACAAGACTATGAAGCCACTTCCACATCAATT
CCAGGCCACCTAATCCCATCCGAGGAGGCCATGGGGAGGAGGAGGGAGGGGAGTGGGCTGGGGGGAGAGTCTGTTTTCTGTGCACTCCCT
GTGACTCTGGCCTTTCTTCTTCTTTTTTTAATTGACCAATTTTTAGTTAAAAAGGCAAAAGAAGGTGAATTTGAGATTTACAGAAAACAG
TTCCAGTGTTTGGTTTCCGCTGTCTTTCCTTTCATTTGCCATGTTTTTACATTCTTCCAAATTTGGGGTCACTCCCCTAGCTCCTGATGC
TGCTACTGTACCATCCTTTTGCTCCAGCCATGAGAGCAGACATTGCAGAATGTTGGTTCCAGGTTGGCATGCTCTGAAGCTCTTGAACTG
TAGCACAGGCAGAGCCCTTTTTCTTCCTGTCATCTCCACCCGATTCCTTCCATCCCTACGTCTACCACTCTCTGGGTCCTCACTGGTCTT
CAAAGGACCTGGCTCTCATAGGATCCCCTCAGGATTGTGTGCAGGGAGAGGGGGCTTTGCTGGGGAGGAGCTGGGAGTGGAGAGTTGGAG
GGTGGGTGGGGTTCCCTCATCCAGTTTCCACAGCCCACCATGGCTGGAGCCAAATGCTAGAAGCGAGATTGAGAACAGTGGCCGTTTAGT
GATGTGGTTTACCTAATACCACTGTCCAGCTGTGCAGCTCAGAAAGGATAAACCAGTCAGGGACAGGGGCCAGAACAGGTTTGGGAAGGT
GGCAGCAAGCAGAGCATGGTGGGTAGGAGATGATCCCTAAAAAAACTGGAGACTGTGGTGGTCTGAGCTGGTCAGGAATCTGCAGAATCC
CTTCCAGGAATCAGTGTGCCAGTGCCCACAGCAGGGTGAGCTAGGAGGGAGAAATCCCAGGAAAAAGGTCGTGAGAACCCAGAAAGCCAC
TCCATGAGGAGGCACGGTGACCACAGCTGCTAAAGGTTCTTAGGCTGCCTTCCTGGGCTAGGAAGAGCCCCCCAGGGAGAGCTTCCACAA
AAGGGTATGTGTCAAACCTTTTGTCAGAATAAATAATAGCATTTCCCACCCACCCCCATGCCCTGGGCCACAGGGACTTGGTGGGATCAG
CACACCCATGGATCAGCTTTTGCTGTCTTAGAGACAGCCATCCCCATGAAGGAATGGTAAGGACAGCCACTGCTCAGTGAAGAACAGCCA
TTTGGAAGAGCCACGCTGGAGCCCTGCAGCCATAGAACTATTCACACTGGAGTTTTAAAAGAAACAGCAATACCATAAGCTCTAGTAGGG
AATCATAATCAGGAAAGGAATTCACAACATAAAATAGGTGTTCTGTGCTATTAATCATGTAACTTTGTATATGATGTATAGCAAAGATAC
TGGGAGGTTTTGTTTCATCCTTAAATCAGAAATGAATGCTAGTTTCATAGCTGGGCAGAACCCTCATCCCCACCCCAAAGTTTTCCTTTT
CTTTCCCGTTCCCCCAACCCAAAGATCAGACTACTGTTAAGTTTCACCACACAATTGGAATTGCAAAGACGGGAGGCAAATGGAGTGATT
TTCATCAATGGAATTGCACTGACAGTGAGTGTTTCTTATAGGATTACTAAATTTTTTAATATAAAATGATTTGTTTAAAAATCAGGAGTT
GATATTAAGTACCAGGACATTAGTTCGGATGATTTCATTTTTATTTCTACAGTGTTAAAAGTGCACTTATATGCTGGTTTATTTACGTCT
TGGGAAAAGAGACTGCAAATTGAAGGGATGATTGTTACTTTTTCTTTTTTTAAAAAAAAAAGGTTAAGGAGATTTTAAGACTTATAAATG
TTTAAGAAATTATAAACAAGGTTAGACCCTTTGAAAAAAAGTTTAGAAGATATTCTTAAAGTAAATTTTTATAGTGTTAATTTTGTAATA
ATTTATGTTTTACTATATTACAGAGCTAACTGACCAGAATAGTTTCAGAAACAATATGAAACTTAGGAAAGTTTAAGCAATGTTTATATT
TTTAAAATGTTCTTTGAATTATGTTTTTATTGTACATTTCTTCAGACTGAAAAGTATGTACATATCTTTGTTATTTTTGCACAATTTTGT
CTTGTTCGGTTTCAGAGGTCTGTTGTTTTTTATAATTTATTTTGAGTTGTAAAACTTGCAGGAGTAAAAACAAAAAACAAAATCTCCACA
ACAAAATAACCCTCTGATTTATAAACTCTTATAGTCAAAGAGGGAAAACAAAGGTTGAGAGATTAAGTGGCTGCTTCTGAGAAATAATGT
CTCAAGGACTAAAGGAGCAATTCAATAGGTTTAGACATTGTAGCTCTCTACATCTTGAATTGGAAGCTGGAATAAAGAGCCCCCACCCCC
CCCCCCACCCTCATCGAATGCTGCTTACTTTGTCAAAAGACTGGCTATGACCAAGGTGAGGATATTTCTGGAAAACTGGGCAAAAAGGGA
AAGCCCACAGTATTCTTCCTTGGCAGTCAACCACAGGTTTACTTTACAATGATGTATTAAAAACTTGCAGCTTGAAAAATGGAATGCAAA
TAAAAGGTTCTCTTTGGGTTTGTCTTAATGGAGTTAAACTGGAGCAGCCTATAAAACATTTTTAGGGTGATGTCCTCTGGGTCCTTCTGT
TCTGCACACCCACTCAGTCTTCTCTCCCAGCCCCTTGACTGCACACACCCCTCTTTGCCTGAAGATCTCCTGACTTGTCGCCAGCCATAG

>In-frame_ENST00000454757_ENST00000419735_TCGA-VQ-AA6I_EGFR_chr7_55269475_+_ATXN7L1_chr7_105251050_length(amino acids)=1051AA_start in transcript=144_stop in transcript=3299
MGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKT
GLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCS
GRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRA
CGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKE
ITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKI
ISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCI
QCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRR
RHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEIL
DEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQH
VKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICT
IDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTS

--------------------------------------------------------------
>In-frame_ENST00000454757_ENST00000477775_TCGA-VQ-AA6I_EGFR_chr7_55269475_+_ATXN7L1_chr7_105251050_length(transcript)=3384nt_BP=3186nt
ACTGGACTTCAGAACAAGAGGGAGCTCTGGGCTGCTGGCTGGTTGTGCATTTGCTGTGGGTTCCCTCCGGCAGGCGACCTCTCCGCGCTG
AGAAGGTTATCCGGATAACCAATTTGCCAAGGCACGAGTAACAAGCTCACGCAGTTGGGCACTTTTGAAGATCATTTTCTCAGCCTCCAG
AGGATGTTCAATAACTGTGAGGTGGTCCTTGGGAATTTGGAAATTACCTATGTGCAGAGGAATTATGATCTTTCCTTCTTAAAGACCATC
CAGGAGGTGGCTGGTTATGTCCTCATTGCCCTCAACACAGTGGAGCGAATTCCTTTGGAAAACCTGCAGATCATCAGAGGAAATATGTAC
TACGAAAATTCCTATGCCTTAGCAGTCTTATCTAACTATGATGCAAATAAAACCGGACTGAAGGAGCTGCCCATGAGAAATTTACAGGAA
ATCCTGCATGGCGCCGTGCGGTTCAGCAACAACCCTGCCCTGTGCAACGTGGAGAGCATCCAGTGGCGGGACATAGTCAGCAGTGACTTT
CTCAGCAACATGTCGATGGACTTCCAGAACCACCTGGGCAGCTGCCAAAAGTGTGATCCAAGCTGTCCCAATGGGAGCTGCTGGGGTGCA
GGAGAGGAGAACTGCCAGAAACTGACCAAAATCATCTGTGCCCAGCAGTGCTCCGGGCGCTGCCGTGGCAAGTCCCCCAGTGACTGCTGC
CACAACCAGTGTGCTGCAGGCTGCACAGGCCCCCGGGAGAGCGACTGCCTGGTCTGCCGCAAATTCCGAGACGAAGCCACGTGCAAGGAC
ACCTGCCCCCCACTCATGCTCTACAACCCCACCACGTACCAGATGGATGTGAACCCCGAGGGCAAATACAGCTTTGGTGCCACCTGCGTG
AAGAAGTGTCCCCGTAATTATGTGGTGACAGATCACGGCTCGTGCGTCCGAGCCTGTGGGGCCGACAGCTATGAGATGGAGGAAGACGGC
GTCCGCAAGTGTAAGAAGTGCGAAGGGCCTTGCCGCAAAGTGTGTAACGGAATAGGTATTGGTGAATTTAAAGACTCACTCTCCATAAAT
GCTACGAATATTAAACACTTCAAAAACTGCACCTCCATCAGTGGCGATCTCCACATCCTGCCGGTGGCATTTAGGGGTGACTCCTTCACA
CATACTCCTCCTCTGGATCCACAGGAACTGGATATTCTGAAAACCGTAAAGGAAATCACAGGGTTTTTGCTGATTCAGGCTTGGCCTGAA
AACAGGACGGACCTCCATGCCTTTGAGAACCTAGAAATCATACGCGGCAGGACCAAGCAACATGGTCAGTTTTCTCTTGCAGTCGTCAGC
CTGAACATAACATCCTTGGGATTACGCTCCCTCAAGGAGATAAGTGATGGAGATGTGATAATTTCAGGAAACAAAAATTTGTGCTATGCA
AATACAATAAACTGGAAAAAACTGTTTGGGACCTCCGGTCAGAAAACCAAAATTATAAGCAACAGAGGTGAAAACAGCTGCAAGGCCACA
GGCCAGGTCTGCCATGCCTTGTGCTCCCCCGAGGGCTGCTGGGGCCCGGAGCCCAGGGACTGCGTCTCTTGCCGGAATGTCAGCCGAGGC
AGGGAATGCGTGGACAAGTGCAACCTTCTGGAGGGTGAGCCAAGGGAGTTTGTGGAGAACTCTGAGTGCATACAGTGCCACCCAGAGTGC
CTGCCTCAGGCCATGAACATCACCTGCACAGGACGGGGACCAGACAACTGTATCCAGTGTGCCCACTACATTGACGGCCCCCACTGCGTC
AAGACCTGCCCGGCAGGAGTCATGGGAGAAAACAACACCCTGGTCTGGAAGTACGCAGACGCCGGCCATGTGTGCCACCTGTGCCATCCA
AACTGCACCTACGGATGCACTGGGCCAGGTCTTGAAGGCTGTCCAACGAATGGGCCTAAGATCCCGTCCATCGCCACTGGGATGGTGGGG
GCCCTCCTCTTGCTGCTGGTGGTGGCCCTGGGGATCGGCCTCTTCATGCGAAGGCGCCACATCGTTCGGAAGCGCACGCTGCGGAGGCTG
CTGCAGGAGAGGGAGCTTGTGGAGCCTCTTACACCCAGTGGAGAAGCTCCCAACCAAGCTCTCTTGAGGATCTTGAAGGAAACTGAATTC
AAAAAGATCAAAGTGCTGGGCTCCGGTGCGTTCGGCACGGTGTATAAGGGACTCTGGATCCCAGAAGGTGAGAAAGTTAAAATTCCCGTC
GCTATCAAGGAATTAAGAGAAGCAACATCTCCGAAAGCCAACAAGGAAATCCTCGATGAAGCCTACGTGATGGCCAGCGTGGACAACCCC
CACGTGTGCCGCCTGCTGGGCATCTGCCTCACCTCCACCGTGCAGCTCATCACGCAGCTCATGCCCTTCGGCTGCCTCCTGGACTATGTC
CGGGAACACAAAGACAATATTGGCTCCCAGTACCTGCTCAACTGGTGTGTGCAGATCGCAAAGGGCATGAACTACTTGGAGGACCGTCGC
TTGGTGCACCGCGACCTGGCAGCCAGGAACGTACTGGTGAAAACACCGCAGCATGTCAAGATCACAGATTTTGGGCTGGCCAAACTGCTG
GGTGCGGAAGAGAAAGAATACCATGCAGAAGGAGGCAAAGTGCCTATCAAGTGGATGGCATTGGAATCAATTTTACACAGAATCTATACC
CACCAGAGTGATGTCTGGAGCTACGGGGTGACTGTTTGGGAGTTGATGACCTTTGGATCCAAGCCATATGACGGAATCCCTGCCAGCGAG
ATCTCCTCCATCCTGGAGAAAGGAGAACGCCTCCCTCAGCCACCCATATGTACCATCGATGTCTACATGATCATGGTCAAGTGCTGGATG
ATAGACGCAGATAGTCGCCCAAAGTTCCGTGAGTTGATCATCGAATTCTCCAAAATGGCCCGAGACCCCCAGCGCTACCTTGTCATTCAG
GGGGATGAAAGAATGCATTTGCCAAGTCCTACAGACTCCAACTTCTACCGTGCCCTGATGGATGAAGAAGACATGGACGACGTGGTGGAT
GCCGACGAGTACCTCATCCCACAGCAGGGCTTCTTCAGCAGCCCCTCCACGTCACGGACTCCCCTCCTGAGCTCTCTGAGTGCAACCAGC
AACAATTCCACCGTGGCTTGCATTGATAGAAATGGGGTTGGGAAAAATAGCAGCCTAGCTTTGTCACAATCCAGTCCTTCAAGTATATCC
AGCCCAGGACACAGCCGACAGAAGAACACAAACAGAACGGGCAGGATAAGGACTCTTCCATAACAAGACTATGAAGCCACTTCCACATCA

>In-frame_ENST00000454757_ENST00000477775_TCGA-VQ-AA6I_EGFR_chr7_55269475_+_ATXN7L1_chr7_105251050_length(amino acids)=1052AA_start in transcript=144_stop in transcript=3302
MGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKT
GLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCS
GRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRA
CGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKE
ITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKI
ISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCI
QCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRR
RHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEIL
DEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQH
VKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICT
IDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for EGFR-ATXN7L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EGFR-ATXN7L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneEGFRP00533DB00002CetuximabAntagonistBiotechApproved
HgeneEGFRP00533DB00002CetuximabAntagonistBiotechApproved
HgeneEGFRP00533DB00002CetuximabAntagonistBiotechApproved
HgeneEGFRP00533DB00002CetuximabAntagonistBiotechApproved
HgeneEGFRP00533DB05294VandetanibInhibitorSmall moleculeApproved
HgeneEGFRP00533DB05294VandetanibInhibitorSmall moleculeApproved
HgeneEGFRP00533DB05294VandetanibInhibitorSmall moleculeApproved
HgeneEGFRP00533DB05294VandetanibInhibitorSmall moleculeApproved
HgeneEGFRP00533DB08916AfatinibInhibitorSmall moleculeApproved
HgeneEGFRP00533DB08916AfatinibInhibitorSmall moleculeApproved
HgeneEGFRP00533DB08916AfatinibInhibitorSmall moleculeApproved
HgeneEGFRP00533DB08916AfatinibInhibitorSmall moleculeApproved
HgeneEGFRP00533DB09330OsimertinibInhibitorSmall moleculeApproved
HgeneEGFRP00533DB09330OsimertinibInhibitorSmall moleculeApproved
HgeneEGFRP00533DB09330OsimertinibInhibitorSmall moleculeApproved
HgeneEGFRP00533DB09330OsimertinibInhibitorSmall moleculeApproved
HgeneEGFRP00533DB10772Foreskin keratinocyte (neonatal)AgonistBiotechApproved
HgeneEGFRP00533DB10772Foreskin keratinocyte (neonatal)AgonistBiotechApproved
HgeneEGFRP00533DB10772Foreskin keratinocyte (neonatal)AgonistBiotechApproved
HgeneEGFRP00533DB10772Foreskin keratinocyte (neonatal)AgonistBiotechApproved
HgeneEGFRP00533DB00317GefitinibAntagonistSmall moleculeApproved|Investigational
HgeneEGFRP00533DB00317GefitinibAntagonistSmall moleculeApproved|Investigational
HgeneEGFRP00533DB00317GefitinibAntagonistSmall moleculeApproved|Investigational
HgeneEGFRP00533DB00317GefitinibAntagonistSmall moleculeApproved|Investigational
HgeneEGFRP00533DB00530ErlotinibAntagonistSmall moleculeApproved|Investigational
HgeneEGFRP00533DB00530ErlotinibAntagonistSmall moleculeApproved|Investigational
HgeneEGFRP00533DB00530ErlotinibAntagonistSmall moleculeApproved|Investigational
HgeneEGFRP00533DB00530ErlotinibAntagonistSmall moleculeApproved|Investigational
HgeneEGFRP00533DB01259LapatinibAntagonistSmall moleculeApproved|Investigational
HgeneEGFRP00533DB01259LapatinibAntagonistSmall moleculeApproved|Investigational
HgeneEGFRP00533DB01259LapatinibAntagonistSmall moleculeApproved|Investigational
HgeneEGFRP00533DB01259LapatinibAntagonistSmall moleculeApproved|Investigational
HgeneEGFRP00533DB01269PanitumumabSuppressorBiotechApproved|Investigational
HgeneEGFRP00533DB01269PanitumumabSuppressorBiotechApproved|Investigational
HgeneEGFRP00533DB01269PanitumumabSuppressorBiotechApproved|Investigational
HgeneEGFRP00533DB01269PanitumumabSuppressorBiotechApproved|Investigational
HgeneEGFRP00533DB09559NecitumumabAntagonistBiotechApproved|Investigational
HgeneEGFRP00533DB09559NecitumumabAntagonistBiotechApproved|Investigational
HgeneEGFRP00533DB09559NecitumumabAntagonistBiotechApproved|Investigational
HgeneEGFRP00533DB09559NecitumumabAntagonistBiotechApproved|Investigational
HgeneEGFRP00533DB11828NeratinibInhibitorSmall moleculeApproved|Investigational
HgeneEGFRP00533DB11828NeratinibInhibitorSmall moleculeApproved|Investigational
HgeneEGFRP00533DB11828NeratinibInhibitorSmall moleculeApproved|Investigational
HgeneEGFRP00533DB11828NeratinibInhibitorSmall moleculeApproved|Investigational
HgeneEGFRP00533DB11963DacomitinibInhibitorSmall moleculeApproved|Investigational
HgeneEGFRP00533DB11963DacomitinibInhibitorSmall moleculeApproved|Investigational
HgeneEGFRP00533DB11963DacomitinibInhibitorSmall moleculeApproved|Investigational
HgeneEGFRP00533DB11963DacomitinibInhibitorSmall moleculeApproved|Investigational
HgeneEGFRP00533DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
HgeneEGFRP00533DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
HgeneEGFRP00533DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
HgeneEGFRP00533DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
HgeneEGFRP00533DB12267BrigatinibInhibitorSmall moleculeApproved|Investigational
HgeneEGFRP00533DB12267BrigatinibInhibitorSmall moleculeApproved|Investigational
HgeneEGFRP00533DB12267BrigatinibInhibitorSmall moleculeApproved|Investigational
HgeneEGFRP00533DB12267BrigatinibInhibitorSmall moleculeApproved|Investigational
HgeneEGFRP00533DB15035ZanubrutinibInhibitorSmall moleculeApproved|Investigational
HgeneEGFRP00533DB15035ZanubrutinibInhibitorSmall moleculeApproved|Investigational
HgeneEGFRP00533DB15035ZanubrutinibInhibitorSmall moleculeApproved|Investigational
HgeneEGFRP00533DB15035ZanubrutinibInhibitorSmall moleculeApproved|Investigational
HgeneEGFRP00533DB00281LidocaineAntagonistSmall moleculeApproved|Vet_approved
HgeneEGFRP00533DB00281LidocaineAntagonistSmall moleculeApproved|Vet_approved
HgeneEGFRP00533DB00281LidocaineAntagonistSmall moleculeApproved|Vet_approved
HgeneEGFRP00533DB00281LidocaineAntagonistSmall moleculeApproved|Vet_approved

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Related Diseases for EGFR-ATXN7L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEGFRC0007131Non-Small Cell Lung Carcinoma16CGI;CTD_human
HgeneEGFRC0024121Lung Neoplasms7CGI;CTD_human
HgeneEGFRC0242379Malignant neoplasm of lung7CGI;CTD_human
HgeneEGFRC0006142Malignant neoplasm of breast6CTD_human
HgeneEGFRC0678222Breast Carcinoma6CTD_human
HgeneEGFRC1257931Mammary Neoplasms, Human6CTD_human
HgeneEGFRC1458155Mammary Neoplasms6CTD_human
HgeneEGFRC4704874Mammary Carcinoma, Human6CTD_human
HgeneEGFRC0001418Adenocarcinoma5CTD_human
HgeneEGFRC0205641Adenocarcinoma, Basal Cell5CTD_human
HgeneEGFRC0205642Adenocarcinoma, Oxyphilic5CTD_human
HgeneEGFRC0205643Carcinoma, Cribriform5CTD_human
HgeneEGFRC0205644Carcinoma, Granular Cell5CTD_human
HgeneEGFRC0205645Adenocarcinoma, Tubular5CTD_human
HgeneEGFRC0334588Giant Cell Glioblastoma5CTD_human;ORPHANET
HgeneEGFRC0007137Squamous cell carcinoma3CTD_human
HgeneEGFRC0007873Uterine Cervical Neoplasm3CTD_human
HgeneEGFRC0014859Esophageal Neoplasms3CGI;CTD_human
HgeneEGFRC0017636Glioblastoma3CGI;CTD_human
HgeneEGFRC0018671Head and Neck Neoplasms3CGI;CTD_human
HgeneEGFRC0018675Head Neoplasms3CTD_human
HgeneEGFRC0024623Malignant neoplasm of stomach3CTD_human
HgeneEGFRC0027533Neck Neoplasms3CTD_human
HgeneEGFRC0027627Neoplasm Metastasis3CTD_human
HgeneEGFRC0033578Prostatic Neoplasms3CTD_human
HgeneEGFRC0038356Stomach Neoplasms3CTD_human
HgeneEGFRC0278996Malignant Head and Neck Neoplasm3CGI;CTD_human
HgeneEGFRC0376358Malignant neoplasm of prostate3CTD_human
HgeneEGFRC0546837Malignant neoplasm of esophagus3CGI;CTD_human
HgeneEGFRC0746787Cancer of Neck3CTD_human
HgeneEGFRC0751177Cancer of Head3CTD_human
HgeneEGFRC0887900Upper Aerodigestive Tract Neoplasms3CTD_human
HgeneEGFRC1621958Glioblastoma Multiforme3CTD_human
HgeneEGFRC1708349Hereditary Diffuse Gastric Cancer3CTD_human
HgeneEGFRC4048328cervical cancer3CTD_human
HgeneEGFRC0005684Malignant neoplasm of urinary bladder2CTD_human
HgeneEGFRC0005695Bladder Neoplasm2CTD_human
HgeneEGFRC0007102Malignant tumor of colon2CTD_human
HgeneEGFRC0009375Colonic Neoplasms2CTD_human
HgeneEGFRC0009402Colorectal Carcinoma2CTD_human
HgeneEGFRC0009404Colorectal Neoplasms2CTD_human
HgeneEGFRC0024668Mammary Neoplasms, Experimental2CTD_human
HgeneEGFRC0027626Neoplasm Invasiveness2CTD_human
HgeneEGFRC0027643Neoplasm Recurrence, Local2CTD_human
HgeneEGFRC0152013Adenocarcinoma of lung (disorder)2CGI;CTD_human
HgeneEGFRC0206726gliosarcoma2ORPHANET
HgeneEGFRC0919267ovarian neoplasm2CTD_human
HgeneEGFRC1140680Malignant neoplasm of ovary2CTD_human
HgeneEGFRC4015130INFLAMMATORY SKIN AND BOWEL DISEASE, NEONATAL, 22CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneEGFRC0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneEGFRC0003865Arthritis, Adjuvant-Induced1CTD_human
HgeneEGFRC0005396Bile Duct Neoplasms1CTD_human
HgeneEGFRC0007097Carcinoma1CTD_human
HgeneEGFRC0007113Rectal Carcinoma1CTD_human
HgeneEGFRC0007193Cardiomyopathy, Dilated1CTD_human
HgeneEGFRC0011603Dermatitis1CTD_human
HgeneEGFRC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
HgeneEGFRC0014175Endometriosis1CTD_human
HgeneEGFRC0016978gallbladder neoplasm1CTD_human
HgeneEGFRC0021655Insulin Resistance1CTD_human
HgeneEGFRC0022660Kidney Failure, Acute1CTD_human
HgeneEGFRC0024667Animal Mammary Neoplasms1CTD_human
HgeneEGFRC0024809Marijuana Abuse1PSYGENET
HgeneEGFRC0025500Mesothelioma1CTD_human
HgeneEGFRC0027439Nasopharyngeal Neoplasms1CTD_human
HgeneEGFRC0029463Osteosarcoma1CTD_human
HgeneEGFRC0030297Pancreatic Neoplasm1CTD_human
HgeneEGFRC0030354Papilloma1CTD_human
HgeneEGFRC0032580Adenomatous Polyposis Coli1CTD_human
HgeneEGFRC0034885Rectal Neoplasms1CTD_human
HgeneEGFRC0041696Unipolar Depression1PSYGENET
HgeneEGFRC0085548Autosomal Recessive Polycystic Kidney Disease1CTD_human
HgeneEGFRC0085762Alcohol abuse1PSYGENET
HgeneEGFRC0149925Small cell carcinoma of lung1CTD_human
HgeneEGFRC0153452Malignant neoplasm of gallbladder1CTD_human
HgeneEGFRC0205696Anaplastic carcinoma1CTD_human
HgeneEGFRC0205697Carcinoma, Spindle-Cell1CTD_human
HgeneEGFRC0205698Undifferentiated carcinoma1CTD_human
HgeneEGFRC0205699Carcinomatosis1CTD_human
HgeneEGFRC0205874Papilloma, Squamous Cell1CTD_human
HgeneEGFRC0205875Papillomatosis1CTD_human
HgeneEGFRC0206686Adrenocortical carcinoma1CTD_human
HgeneEGFRC0206698Cholangiocarcinoma1CTD_human
HgeneEGFRC0235874Disease Exacerbation1CTD_human
HgeneEGFRC0238301Cancer of Nasopharynx1CTD_human
HgeneEGFRC0263454Chloracne1CTD_human
HgeneEGFRC0269102Endometrioma1CTD_human
HgeneEGFRC0279626Squamous cell carcinoma of esophagus1CGI;CTD_human
HgeneEGFRC0345905Intrahepatic Cholangiocarcinoma1CTD_human
HgeneEGFRC0345967Malignant mesothelioma1CTD_human
HgeneEGFRC0346647Malignant neoplasm of pancreas1CTD_human
HgeneEGFRC0376634Craniofacial Abnormalities1CTD_human
HgeneEGFRC0740277Bile duct carcinoma1CTD_human
HgeneEGFRC0920563Insulin Sensitivity1CTD_human
HgeneEGFRC0971858Arthritis, Collagen-Induced1CTD_human
HgeneEGFRC0993582Arthritis, Experimental1CTD_human
HgeneEGFRC1257925Mammary Carcinoma, Animal1CTD_human
HgeneEGFRC1269683Major Depressive Disorder1PSYGENET
HgeneEGFRC1449563Cardiomyopathy, Familial Idiopathic1CTD_human
HgeneEGFRC1565662Acute Kidney Insufficiency1CTD_human
HgeneEGFRC2239176Liver carcinoma1CTD_human
HgeneEGFRC2609414Acute kidney injury1CTD_human
HgeneEGFRC2713442Polyposis, Adenomatous Intestinal1CTD_human
HgeneEGFRC2713443Familial Intestinal Polyposis1CTD_human
HgeneEGFRC3805278Extrahepatic Cholangiocarcinoma1CTD_human
HgeneEGFRC4751120Neonatal inflammatory skin and bowel disease1ORPHANET