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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EHBP1L1-POLA2 (FusionGDB2 ID:25520)

Fusion Gene Summary for EHBP1L1-POLA2

check button Fusion gene summary
Fusion gene informationFusion gene name: EHBP1L1-POLA2
Fusion gene ID: 25520
HgeneTgene
Gene symbol

EHBP1L1

POLA2

Gene ID

254102

23649

Gene nameEH domain binding protein 1 like 1DNA polymerase alpha 2, accessory subunit
Synonyms--
Cytomap

11q13.1

11q13.1

Type of geneprotein-codingprotein-coding
DescriptionEH domain-binding protein 1-like protein 1tangerinDNA polymerase alpha subunit BDNA polymerase alpha 70 kDa subunitpolymerase (DNA directed), alpha 2 (70kD subunit)polymerase (DNA directed), alpha 2, accessory subunitpolymerase (DNA) alpha 2, accessory subunitpolymerase (DNA-directed), alpha (70kD)
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000309295, ENST00000529596, 
ENST00000533364, 		ENST00000265465, 
ENST00000541089, ENST00000534785, 
Fusion gene scores* DoF score8 X 6 X 5=24010 X 14 X 6=840
# samples 916
** MAII scorelog2(9/240*10)=-1.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/840*10)=-2.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EHBP1L1 [Title/Abstract] AND POLA2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEHBP1L1(65343877)-POLA2(65061624), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across EHBP1L1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across POLA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-1470-01AEHBP1L1chr11

65343877

+POLA2chr11

65061624

+
ChimerDB4OVTCGA-24-1470EHBP1L1chr11

65343877

+POLA2chr11

65061623

+
ChimerDB4OVTCGA-24-1470-01AEHBP1L1chr11

65343877

+POLA2chr11

65061624

+


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Fusion Gene ORF analysis for EHBP1L1-POLA2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000309295ENST00000265465EHBP1L1chr11

65343877

+POLA2chr11

65061624

+
In-frameENST00000309295ENST00000541089EHBP1L1chr11

65343877

+POLA2chr11

65061624

+
5CDS-intronENST00000309295ENST00000534785EHBP1L1chr11

65343877

+POLA2chr11

65061624

+
intron-3CDSENST00000529596ENST00000265465EHBP1L1chr11

65343877

+POLA2chr11

65061624

+
intron-3CDSENST00000529596ENST00000541089EHBP1L1chr11

65343877

+POLA2chr11

65061624

+
intron-intronENST00000529596ENST00000534785EHBP1L1chr11

65343877

+POLA2chr11

65061624

+
intron-3CDSENST00000533364ENST00000265465EHBP1L1chr11

65343877

+POLA2chr11

65061624

+
intron-3CDSENST00000533364ENST00000541089EHBP1L1chr11

65343877

+POLA2chr11

65061624

+
intron-intronENST00000533364ENST00000534785EHBP1L1chr11

65343877

+POLA2chr11

65061624

+
In-frameENST00000309295ENST00000265465EHBP1L1chr11

65343877

+POLA2chr11

65061623

+
In-frameENST00000309295ENST00000541089EHBP1L1chr11

65343877

+POLA2chr11

65061623

+
5CDS-intronENST00000309295ENST00000534785EHBP1L1chr11

65343877

+POLA2chr11

65061623

+
intron-3CDSENST00000529596ENST00000265465EHBP1L1chr11

65343877

+POLA2chr11

65061623

+
intron-3CDSENST00000529596ENST00000541089EHBP1L1chr11

65343877

+POLA2chr11

65061623

+
intron-intronENST00000529596ENST00000534785EHBP1L1chr11

65343877

+POLA2chr11

65061623

+
intron-3CDSENST00000533364ENST00000265465EHBP1L1chr11

65343877

+POLA2chr11

65061623

+
intron-3CDSENST00000533364ENST00000541089EHBP1L1chr11

65343877

+POLA2chr11

65061623

+
intron-intronENST00000533364ENST00000534785EHBP1L1chr11

65343877

+POLA2chr11

65061623

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000309295EHBP1L1chr1165343877+ENST00000265465POLA2chr1165061624+2338369265921218
ENST00000309295EHBP1L1chr1165343877+ENST00000541089POLA2chr1165061624+992369265834189
ENST00000309295EHBP1L1chr1165343877+ENST00000265465POLA2chr1165061623+2338369265921218
ENST00000309295EHBP1L1chr1165343877+ENST00000541089POLA2chr1165061623+992369265834189

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000309295ENST00000265465EHBP1L1chr1165343877+POLA2chr1165061624+0.045417390.95458263
ENST00000309295ENST00000541089EHBP1L1chr1165343877+POLA2chr1165061624+0.0300504570.9699496
ENST00000309295ENST00000265465EHBP1L1chr1165343877+POLA2chr1165061623+0.045417390.95458263
ENST00000309295ENST00000541089EHBP1L1chr1165343877+POLA2chr1165061623+0.0300504570.9699496

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Fusion Genomic Features for EHBP1L1-POLA2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
EHBP1L1chr1165343877+POLA2chr1165061623+0.0062364260.9937636
EHBP1L1chr1165343877+POLA2chr1165061623+0.0062364260.9937636
EHBP1L1chr1165343877+POLA2chr1165061623+0.0062364260.9937636
EHBP1L1chr1165343877+POLA2chr1165061623+0.0062364260.9937636

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EHBP1L1-POLA2


check button Go to

FGviewer for the breakpoints of chr11:65343877-chr11:65061624

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePOLA2chr11:65343877chr11:65061623ENST000002654651218486_489414.6666666666667599.0Compositional biasNote=Poly-Ser
TgenePOLA2chr11:65343877chr11:65061624ENST000002654651218486_489414.6666666666667599.0Compositional biasNote=Poly-Ser

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEHBP1L1chr11:65343877chr11:65061623ENST00000309295+1191363_151534.6666666666666641524.0Coiled coilOntology_term=ECO:0000255
HgeneEHBP1L1chr11:65343877chr11:65061624ENST00000309295+1191363_151534.6666666666666641524.0Coiled coilOntology_term=ECO:0000255
HgeneEHBP1L1chr11:65343877chr11:65061623ENST00000309295+1191153_115834.6666666666666641524.0Compositional biasNote=Poly-Gly
HgeneEHBP1L1chr11:65343877chr11:65061623ENST00000309295+1191247_125034.6666666666666641524.0Compositional biasNote=Poly-Gly
HgeneEHBP1L1chr11:65343877chr11:65061623ENST00000309295+1191308_131134.6666666666666641524.0Compositional biasNote=Poly-Ala
HgeneEHBP1L1chr11:65343877chr11:65061623ENST00000309295+1191316_134734.6666666666666641524.0Compositional biasNote=Pro-rich
HgeneEHBP1L1chr11:65343877chr11:65061623ENST00000309295+119222_22634.6666666666666641524.0Compositional biasNote=Poly-Glu
HgeneEHBP1L1chr11:65343877chr11:65061623ENST00000309295+119561_89034.6666666666666641524.0Compositional biasNote=Glu-rich
HgeneEHBP1L1chr11:65343877chr11:65061624ENST00000309295+1191153_115834.6666666666666641524.0Compositional biasNote=Poly-Gly
HgeneEHBP1L1chr11:65343877chr11:65061624ENST00000309295+1191247_125034.6666666666666641524.0Compositional biasNote=Poly-Gly
HgeneEHBP1L1chr11:65343877chr11:65061624ENST00000309295+1191308_131134.6666666666666641524.0Compositional biasNote=Poly-Ala
HgeneEHBP1L1chr11:65343877chr11:65061624ENST00000309295+1191316_134734.6666666666666641524.0Compositional biasNote=Pro-rich
HgeneEHBP1L1chr11:65343877chr11:65061624ENST00000309295+119222_22634.6666666666666641524.0Compositional biasNote=Poly-Glu
HgeneEHBP1L1chr11:65343877chr11:65061624ENST00000309295+119561_89034.6666666666666641524.0Compositional biasNote=Glu-rich
HgeneEHBP1L1chr11:65343877chr11:65061623ENST00000309295+1191037_114234.6666666666666641524.0DomainCalponin-homology (CH)
HgeneEHBP1L1chr11:65343877chr11:65061623ENST00000309295+1191349_150134.6666666666666641524.0DomainbMERB
HgeneEHBP1L1chr11:65343877chr11:65061623ENST00000309295+1198_15734.6666666666666641524.0DomainC2 NT-type
HgeneEHBP1L1chr11:65343877chr11:65061624ENST00000309295+1191037_114234.6666666666666641524.0DomainCalponin-homology (CH)
HgeneEHBP1L1chr11:65343877chr11:65061624ENST00000309295+1191349_150134.6666666666666641524.0DomainbMERB
HgeneEHBP1L1chr11:65343877chr11:65061624ENST00000309295+1198_15734.6666666666666641524.0DomainC2 NT-type
HgeneEHBP1L1chr11:65343877chr11:65061623ENST00000309295+1191520_152334.6666666666666641524.0MotifCAAX motif
HgeneEHBP1L1chr11:65343877chr11:65061624ENST00000309295+1191520_152334.6666666666666641524.0MotifCAAX motif
TgenePOLA2chr11:65343877chr11:65061623ENST000002654651218101_107414.6666666666667599.0Compositional biasNote=Poly-Glu
TgenePOLA2chr11:65343877chr11:65061623ENST000002654651218115_157414.6666666666667599.0Compositional biasNote=Pro/Ser/Thr-rich
TgenePOLA2chr11:65343877chr11:65061624ENST000002654651218101_107414.6666666666667599.0Compositional biasNote=Poly-Glu
TgenePOLA2chr11:65343877chr11:65061624ENST000002654651218115_157414.6666666666667599.0Compositional biasNote=Pro/Ser/Thr-rich


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Fusion Gene Sequence for EHBP1L1-POLA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000309295_ENST00000265465_TCGA-24-1470-01A_EHBP1L1_chr11_65343877_+_POLA2_chr11_65061624_length(transcript)=2338nt_BP=369nt
CGGGGGTGCGGCTCCAGGAAACGGCGCGCTCCCAGCTCCGCGCTCGCCACCCGACGCGCCCCAGGCGACCCCGCAGACTCAGCCAGACCA
CCCTGCGGGCCCCAGCGGCGGCAGCGGAGAGCGCGGTCCCGGGTCGGAGCCTGGGACACCTCCGCACGGACGGGGCGGGCGGCGCGGACA
GGCCATGGGGACCCGGGCCGGGCCAGCGGTGGCGGGCCAGCGGGAGCCCCGGGCCTGAGAAGTGGGCGGCGGGGTGGCGGGGGCCATGAC
CTCGGTGTGGAAGCGCCTGCAGCGCGTGGGCAAGCGGGCGGCCAAGTTCCAGTTCGTGGCCTGTTACCACGAGCTAGTGTTGGAGTGCAC
CAAGAAATGCTCCGGCTCCCACCTTGTCTTTGTCCCGTCATTGAGAGATGTGCACCATGAGCCTGTGTACCCCCAGCCGCCTTTCAGCTA
CTCCGATCTGTCTCGAGAGGACAAAAAGCAAGTACAGTTTGTGTCCGAGCCCTGCAGCCTCTCCATAAACGGAGTGATCTTCGGCTTGAC
ATCCACAGATCTGCTTTTCCACCTGGGGGCCGAGGAGATCAGTAGTTCTTCCGGAACTTCAGACAGATTCAGCCGAATACTCAAGCACAT
CTTGACCCAGAGGAGCTACTACCCACTCTACCCGCCCCAAGAAGACATGGCCATTGACTATGAGTCGTTCTATGTTTACGCACAGCTGCC
TGTCACCCCAGATGTCCTCATCATCCCGTCAGAGCTGAGGTACTTCGTGAAGGATGTCCTCGGCTGTGTCTGTGTGAACCCTGGGCGCCT
TACCAAAGGGCAGGTGGGAGGCACCTTCGCCCGACTCTACCTTAGGAGGCCGGCAGCGGACGGGGCAGAGAGGCAGAGCCCATGCATTGC
TGTGCAGGTCGTCAGGATCTGAGGCTTCTGTCCTCTGCTGTTCTCTGCTGTGTGGGCCCTTAAAGTCTTAGCCAAGAGCCAAGACATAGC
CCTGTGACAAGGTGAACAGTTGGGTGGGAAAGGAGAGAGGAGCCAGCCAGGGAGGGGCAGCTGCAGTGACCAGGCCCAGCAGGGAGGACT
TGTGCAGCCGGGCCTGCCTCTGAGTGGTGCCTCTCCTGGAAGGAAGCTCTTGCTTCTCAGTCCATGCTCCGTGTCCAGAAGTAAGCCAGC
TGTGGATCCCGCCCACTCAGAAAAGGCGAGAAGGCTTTGTGATTTTCTACATGAATCAAACACAGAAACAACTTTTGGAGAAATTAAATT
CTGAGTGTGACTTCTGAGTTTGACCTTTCTTCTATTTTCTTTTATTTATTTATTTTGTTTTTAGACGGAGTCTCGATCTGTCGCCCAGGC
TGGAGTGCAGTGGTGAGATCTCGGCTCACTGCAAGCTCTGCCGCCCGGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGA
CTACAGGCACCCACCACCACGCCTGGCTAATTTTTTGTATTTTTAGTGGAGATGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTC
CTGACCTTGTGATCTGTCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCCCTTTCTTCTATTTTCTT
TATCCTGGTAGTAGACAAAGAATGTTGCCTATTTGACCTATGTCCAGAGAAGGCAGAGTGTCAGTCACACTGGGTTTCTATCCAGCCCCA
GTCCTGTCCAGTGGGTAACTCTCAGCCCCACTCCTCATCCCCCAAAGGCCCCAGTGACCTCTATGCTGCAGAGGTGCACTGGGTGGGCCC
TAGAGCTGGGCTGCAGAGCAAGCAACTGGCTGCATGCCTGGGCCTCCCTGCGCAGTTCCTCACATGCATGCTGTGGTCCCAGCCTGACCT
CTCCATCTGGAGGGGGCCGCCTCGCTGGGCTGTTCCAAAGCTGGAGTCCTGGTGGCAGCTGCTTTGCCAAGTCGCGCAGTAGCCAGGGCT
TGCCTGCAGCCCAGAACACTCAGACAGGGTCAGGCCTTCCAGGGTTCACAGCACGTCCCATGCCCCTATGTCCTGGCATCTGGGGAAAAG
CTGTCACTGGCCAGACGTGGAGTGGCTTCCTGCCCTAAGCTGGCAGGCTGTCCTGCCTCACATGCCAGAGCCAAGACCGGCAAACCCCAG
CTGTCAGGGCAGGGAAGTGGGCAAGGGGGCAGCAAGCTGCTGGTGTCTATGCCTTGACTCCGAGATAAATAGATGACCTAACAGTGGCCA

>In-frame_ENST00000309295_ENST00000265465_TCGA-24-1470-01A_EHBP1L1_chr11_65343877_+_POLA2_chr11_65061624_length(amino acids)=218AA_start in transcript=265_stop in transcript=921
MTSVWKRLQRVGKRAAKFQFVACYHELVLECTKKCSGSHLVFVPSLRDVHHEPVYPQPPFSYSDLSREDKKQVQFVSEPCSLSINGVIFG
LTSTDLLFHLGAEEISSSSGTSDRFSRILKHILTQRSYYPLYPPQEDMAIDYESFYVYAQLPVTPDVLIIPSELRYFVKDVLGCVCVNPG

--------------------------------------------------------------
>In-frame_ENST00000309295_ENST00000541089_TCGA-24-1470-01A_EHBP1L1_chr11_65343877_+_POLA2_chr11_65061624_length(transcript)=992nt_BP=369nt
CGGGGGTGCGGCTCCAGGAAACGGCGCGCTCCCAGCTCCGCGCTCGCCACCCGACGCGCCCCAGGCGACCCCGCAGACTCAGCCAGACCA
CCCTGCGGGCCCCAGCGGCGGCAGCGGAGAGCGCGGTCCCGGGTCGGAGCCTGGGACACCTCCGCACGGACGGGGCGGGCGGCGCGGACA
GGCCATGGGGACCCGGGCCGGGCCAGCGGTGGCGGGCCAGCGGGAGCCCCGGGCCTGAGAAGTGGGCGGCGGGGTGGCGGGGGCCATGAC
CTCGGTGTGGAAGCGCCTGCAGCGCGTGGGCAAGCGGGCGGCCAAGTTCCAGTTCGTGGCCTGTTACCACGAGCTAGTGTTGGAGTGCAC
CAAGAAATGCTCCGGCTCCCACCTTGTCTTTGTCCCGTCATTGAGAGATGTGCACCATGAGCCTGTGTACCCCCAGCCGCCTTTCAGCTA
CTCCGATCTGTCTCGAGAGGACAAAAAGCAAGTACAGTTTGTGTCCGAGCCCTGCAGCCTCTCCATAAACGGAGTGATCTTCGGCTTGAC
ATCCACAGATCTGCTTTTCCACCTGGGGGCCGAGGAGATCAGTAGTTCTTCCGGAACTTCAGACAGATTCAGCCGAATACTCAAGCACAT
CTTGACCCAGAGGAGCTACTACCCACTCTACCCGCCCCAAGAAGACATGGCCATTGACTATGAGTCGTTCTATGTTTACGCACAGCTGCC
TGTCACCCCAGATGTCCTCATCATCCCGTCAGAGCTGAGGTACTTCGTGAAGGTAGGTTTGAACTCTGCTTTTTCCCAGAAACACCAGAA
CCCAGTCTTTGACTTTCCCTTCTAGACCACCCGGCACTCACCCCTCATGGGTCAGCTGATGGGGATGGGGCCTCTAGCACCCTGCCCTGT
GGCCTTGTTTCTTTGGGGAGGTGGTGGGACCAGAAAACAAACAACTCTGTCAGTAAAATGCTTGAGTAAACAGTGTCCTCTCCTCCCTCC

>In-frame_ENST00000309295_ENST00000541089_TCGA-24-1470-01A_EHBP1L1_chr11_65343877_+_POLA2_chr11_65061624_length(amino acids)=189AA_start in transcript=265_stop in transcript=834
MTSVWKRLQRVGKRAAKFQFVACYHELVLECTKKCSGSHLVFVPSLRDVHHEPVYPQPPFSYSDLSREDKKQVQFVSEPCSLSINGVIFG
LTSTDLLFHLGAEEISSSSGTSDRFSRILKHILTQRSYYPLYPPQEDMAIDYESFYVYAQLPVTPDVLIIPSELRYFVKVGLNSAFSQKH

--------------------------------------------------------------
>In-frame_ENST00000309295_ENST00000265465_TCGA-24-1470_EHBP1L1_chr11_65343877_+_POLA2_chr11_65061623_length(transcript)=2338nt_BP=369nt
CGGGGGTGCGGCTCCAGGAAACGGCGCGCTCCCAGCTCCGCGCTCGCCACCCGACGCGCCCCAGGCGACCCCGCAGACTCAGCCAGACCA
CCCTGCGGGCCCCAGCGGCGGCAGCGGAGAGCGCGGTCCCGGGTCGGAGCCTGGGACACCTCCGCACGGACGGGGCGGGCGGCGCGGACA
GGCCATGGGGACCCGGGCCGGGCCAGCGGTGGCGGGCCAGCGGGAGCCCCGGGCCTGAGAAGTGGGCGGCGGGGTGGCGGGGGCCATGAC
CTCGGTGTGGAAGCGCCTGCAGCGCGTGGGCAAGCGGGCGGCCAAGTTCCAGTTCGTGGCCTGTTACCACGAGCTAGTGTTGGAGTGCAC
CAAGAAATGCTCCGGCTCCCACCTTGTCTTTGTCCCGTCATTGAGAGATGTGCACCATGAGCCTGTGTACCCCCAGCCGCCTTTCAGCTA
CTCCGATCTGTCTCGAGAGGACAAAAAGCAAGTACAGTTTGTGTCCGAGCCCTGCAGCCTCTCCATAAACGGAGTGATCTTCGGCTTGAC
ATCCACAGATCTGCTTTTCCACCTGGGGGCCGAGGAGATCAGTAGTTCTTCCGGAACTTCAGACAGATTCAGCCGAATACTCAAGCACAT
CTTGACCCAGAGGAGCTACTACCCACTCTACCCGCCCCAAGAAGACATGGCCATTGACTATGAGTCGTTCTATGTTTACGCACAGCTGCC
TGTCACCCCAGATGTCCTCATCATCCCGTCAGAGCTGAGGTACTTCGTGAAGGATGTCCTCGGCTGTGTCTGTGTGAACCCTGGGCGCCT
TACCAAAGGGCAGGTGGGAGGCACCTTCGCCCGACTCTACCTTAGGAGGCCGGCAGCGGACGGGGCAGAGAGGCAGAGCCCATGCATTGC
TGTGCAGGTCGTCAGGATCTGAGGCTTCTGTCCTCTGCTGTTCTCTGCTGTGTGGGCCCTTAAAGTCTTAGCCAAGAGCCAAGACATAGC
CCTGTGACAAGGTGAACAGTTGGGTGGGAAAGGAGAGAGGAGCCAGCCAGGGAGGGGCAGCTGCAGTGACCAGGCCCAGCAGGGAGGACT
TGTGCAGCCGGGCCTGCCTCTGAGTGGTGCCTCTCCTGGAAGGAAGCTCTTGCTTCTCAGTCCATGCTCCGTGTCCAGAAGTAAGCCAGC
TGTGGATCCCGCCCACTCAGAAAAGGCGAGAAGGCTTTGTGATTTTCTACATGAATCAAACACAGAAACAACTTTTGGAGAAATTAAATT
CTGAGTGTGACTTCTGAGTTTGACCTTTCTTCTATTTTCTTTTATTTATTTATTTTGTTTTTAGACGGAGTCTCGATCTGTCGCCCAGGC
TGGAGTGCAGTGGTGAGATCTCGGCTCACTGCAAGCTCTGCCGCCCGGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGA
CTACAGGCACCCACCACCACGCCTGGCTAATTTTTTGTATTTTTAGTGGAGATGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTC
CTGACCTTGTGATCTGTCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCCCTTTCTTCTATTTTCTT
TATCCTGGTAGTAGACAAAGAATGTTGCCTATTTGACCTATGTCCAGAGAAGGCAGAGTGTCAGTCACACTGGGTTTCTATCCAGCCCCA
GTCCTGTCCAGTGGGTAACTCTCAGCCCCACTCCTCATCCCCCAAAGGCCCCAGTGACCTCTATGCTGCAGAGGTGCACTGGGTGGGCCC
TAGAGCTGGGCTGCAGAGCAAGCAACTGGCTGCATGCCTGGGCCTCCCTGCGCAGTTCCTCACATGCATGCTGTGGTCCCAGCCTGACCT
CTCCATCTGGAGGGGGCCGCCTCGCTGGGCTGTTCCAAAGCTGGAGTCCTGGTGGCAGCTGCTTTGCCAAGTCGCGCAGTAGCCAGGGCT
TGCCTGCAGCCCAGAACACTCAGACAGGGTCAGGCCTTCCAGGGTTCACAGCACGTCCCATGCCCCTATGTCCTGGCATCTGGGGAAAAG
CTGTCACTGGCCAGACGTGGAGTGGCTTCCTGCCCTAAGCTGGCAGGCTGTCCTGCCTCACATGCCAGAGCCAAGACCGGCAAACCCCAG
CTGTCAGGGCAGGGAAGTGGGCAAGGGGGCAGCAAGCTGCTGGTGTCTATGCCTTGACTCCGAGATAAATAGATGACCTAACAGTGGCCA

>In-frame_ENST00000309295_ENST00000265465_TCGA-24-1470_EHBP1L1_chr11_65343877_+_POLA2_chr11_65061623_length(amino acids)=218AA_start in transcript=265_stop in transcript=921
MTSVWKRLQRVGKRAAKFQFVACYHELVLECTKKCSGSHLVFVPSLRDVHHEPVYPQPPFSYSDLSREDKKQVQFVSEPCSLSINGVIFG
LTSTDLLFHLGAEEISSSSGTSDRFSRILKHILTQRSYYPLYPPQEDMAIDYESFYVYAQLPVTPDVLIIPSELRYFVKDVLGCVCVNPG

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>In-frame_ENST00000309295_ENST00000541089_TCGA-24-1470_EHBP1L1_chr11_65343877_+_POLA2_chr11_65061623_length(transcript)=992nt_BP=369nt
CGGGGGTGCGGCTCCAGGAAACGGCGCGCTCCCAGCTCCGCGCTCGCCACCCGACGCGCCCCAGGCGACCCCGCAGACTCAGCCAGACCA
CCCTGCGGGCCCCAGCGGCGGCAGCGGAGAGCGCGGTCCCGGGTCGGAGCCTGGGACACCTCCGCACGGACGGGGCGGGCGGCGCGGACA
GGCCATGGGGACCCGGGCCGGGCCAGCGGTGGCGGGCCAGCGGGAGCCCCGGGCCTGAGAAGTGGGCGGCGGGGTGGCGGGGGCCATGAC
CTCGGTGTGGAAGCGCCTGCAGCGCGTGGGCAAGCGGGCGGCCAAGTTCCAGTTCGTGGCCTGTTACCACGAGCTAGTGTTGGAGTGCAC
CAAGAAATGCTCCGGCTCCCACCTTGTCTTTGTCCCGTCATTGAGAGATGTGCACCATGAGCCTGTGTACCCCCAGCCGCCTTTCAGCTA
CTCCGATCTGTCTCGAGAGGACAAAAAGCAAGTACAGTTTGTGTCCGAGCCCTGCAGCCTCTCCATAAACGGAGTGATCTTCGGCTTGAC
ATCCACAGATCTGCTTTTCCACCTGGGGGCCGAGGAGATCAGTAGTTCTTCCGGAACTTCAGACAGATTCAGCCGAATACTCAAGCACAT
CTTGACCCAGAGGAGCTACTACCCACTCTACCCGCCCCAAGAAGACATGGCCATTGACTATGAGTCGTTCTATGTTTACGCACAGCTGCC
TGTCACCCCAGATGTCCTCATCATCCCGTCAGAGCTGAGGTACTTCGTGAAGGTAGGTTTGAACTCTGCTTTTTCCCAGAAACACCAGAA
CCCAGTCTTTGACTTTCCCTTCTAGACCACCCGGCACTCACCCCTCATGGGTCAGCTGATGGGGATGGGGCCTCTAGCACCCTGCCCTGT
GGCCTTGTTTCTTTGGGGAGGTGGTGGGACCAGAAAACAAACAACTCTGTCAGTAAAATGCTTGAGTAAACAGTGTCCTCTCCTCCCTCC

>In-frame_ENST00000309295_ENST00000541089_TCGA-24-1470_EHBP1L1_chr11_65343877_+_POLA2_chr11_65061623_length(amino acids)=189AA_start in transcript=265_stop in transcript=834
MTSVWKRLQRVGKRAAKFQFVACYHELVLECTKKCSGSHLVFVPSLRDVHHEPVYPQPPFSYSDLSREDKKQVQFVSEPCSLSINGVIFG
LTSTDLLFHLGAEEISSSSGTSDRFSRILKHILTQRSYYPLYPPQEDMAIDYESFYVYAQLPVTPDVLIIPSELRYFVKVGLNSAFSQKH

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Fusion Gene PPI Analysis for EHBP1L1-POLA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EHBP1L1-POLA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EHBP1L1-POLA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource