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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EHD1-BATF2 (FusionGDB2 ID:25524)

Fusion Gene Summary for EHD1-BATF2

check button Fusion gene summary
Fusion gene informationFusion gene name: EHD1-BATF2
Fusion gene ID: 25524
HgeneTgene
Gene symbol

EHD1

BATF2

Gene ID

10938

116071

Gene nameEH domain containing 1basic leucine zipper ATF-like transcription factor 2
SynonymsH-PAST|HPAST1|PAST|PAST1SARI
Cytomap

11q13.1

11q13.1

Type of geneprotein-codingprotein-coding
DescriptionEH domain-containing protein 1PAST homolog 1testilinbasic leucine zipper transcriptional factor ATF-like 2B-ATF-2basic leucine zipper transcription factor, ATF-like 2suppressor of AP-1 regulated by IFN
Modification date2020032920200313
UniProtAcc

Q9H4M9

Q8N1L9

Ensembl transtripts involved in fusion geneENST00000320631, ENST00000359393, 
ENST00000488711, 		ENST00000301887, 
ENST00000435842, ENST00000527716, 
Fusion gene scores* DoF score6 X 7 X 6=2523 X 2 X 4=24
# samples 84
** MAII scorelog2(8/252*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: EHD1 [Title/Abstract] AND BATF2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEHD1(64641893)-BATF2(64757284), # samples:3
EHD1(64641893)-BATF2(64762021), # samples:3
Anticipated loss of major functional domain due to fusion event.EHD1-BATF2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
EHD1-BATF2 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
EHD1-BATF2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across EHD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across BATF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-44-6778-01AEHD1chr11

64641893

-BATF2chr11

64757284

-
ChimerDB4PRADTCGA-YL-A9WK-01AEHD1chr11

64641893

-BATF2chr11

64762021

-
ChimerDB4LUADTCGA-44-6778-01AEHD1chr11

64641893

-BATF2chr11

64757284

-
ChimerDB4PRADTCGA-YL-A9WKEHD1chr11

64641893

-BATF2chr11

64762021

-
ChimerDB4LUADTCGA-44-6778-01AEHD1chr11

64641893

-BATF2chr11

64757284

-
ChimerDB4PRADTCGA-YL-A9WK-01AEHD1chr11

64641893

-BATF2chr11

64762021

-


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Fusion Gene ORF analysis for EHD1-BATF2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000320631ENST00000301887EHD1chr11

64641893

-BATF2chr11

64757284

-
5CDS-5UTRENST00000320631ENST00000435842EHD1chr11

64641893

-BATF2chr11

64757284

-
5CDS-5UTRENST00000320631ENST00000527716EHD1chr11

64641893

-BATF2chr11

64757284

-
In-frameENST00000359393ENST00000301887EHD1chr11

64641893

-BATF2chr11

64757284

-
5CDS-5UTRENST00000359393ENST00000435842EHD1chr11

64641893

-BATF2chr11

64757284

-
5CDS-5UTRENST00000359393ENST00000527716EHD1chr11

64641893

-BATF2chr11

64757284

-
intron-3CDSENST00000488711ENST00000301887EHD1chr11

64641893

-BATF2chr11

64757284

-
intron-5UTRENST00000488711ENST00000435842EHD1chr11

64641893

-BATF2chr11

64757284

-
intron-5UTRENST00000488711ENST00000527716EHD1chr11

64641893

-BATF2chr11

64757284

-
Frame-shiftENST00000320631ENST00000301887EHD1chr11

64641893

-BATF2chr11

64762021

-
5CDS-intronENST00000320631ENST00000435842EHD1chr11

64641893

-BATF2chr11

64762021

-
5CDS-intronENST00000320631ENST00000527716EHD1chr11

64641893

-BATF2chr11

64762021

-
In-frameENST00000359393ENST00000301887EHD1chr11

64641893

-BATF2chr11

64762021

-
5CDS-intronENST00000359393ENST00000435842EHD1chr11

64641893

-BATF2chr11

64762021

-
5CDS-intronENST00000359393ENST00000527716EHD1chr11

64641893

-BATF2chr11

64762021

-
intron-3CDSENST00000488711ENST00000301887EHD1chr11

64641893

-BATF2chr11

64762021

-
intron-intronENST00000488711ENST00000435842EHD1chr11

64641893

-BATF2chr11

64762021

-
intron-intronENST00000488711ENST00000527716EHD1chr11

64641893

-BATF2chr11

64762021

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000359393EHD1chr1164641893-ENST00000301887BATF2chr1164757284-27839137241596290
ENST00000359393EHD1chr1164641893-ENST00000301887BATF2chr1164762021-28859137241698324

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000359393ENST00000301887EHD1chr1164641893-BATF2chr1164757284-0.327840360.6721596
ENST00000359393ENST00000301887EHD1chr1164641893-BATF2chr1164762021-0.0215525810.9784474

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Fusion Genomic Features for EHD1-BATF2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EHD1-BATF2


check button Go to

FGviewer for the breakpoints of chr11:64641893-chr11:64757284

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EHD1

Q9H4M9

BATF2

Q8N1L9

FUNCTION: ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (PubMed:24019528). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (PubMed:15020713, PubMed:17233914, PubMed:20801876). Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth (By similarity). Plays a role in myoblast fusion (By similarity). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis (PubMed:25686250). {ECO:0000250|UniProtKB:Q641Z6, ECO:0000250|UniProtKB:Q9WVK4, ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:24019528, ECO:0000269|PubMed:25686250}.FUNCTION: AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity). Selectively suppresses CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CCN1 and inhibits CCN1-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CCN1 promoter. {ECO:0000250, ECO:0000269|PubMed:20531301}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEHD1chr11:64641893chr11:64757284ENST00000320631-25153_156167.33333333333334535.0RegionG3 motif
HgeneEHD1chr11:64641893chr11:64757284ENST00000320631-2565_72167.33333333333334535.0RegionG1 motif
HgeneEHD1chr11:64641893chr11:64757284ENST00000320631-2591_92167.33333333333334535.0RegionG2 motif
HgeneEHD1chr11:64641893chr11:64757284ENST00000359393-47153_156167.33333333333334535.0RegionG3 motif
HgeneEHD1chr11:64641893chr11:64757284ENST00000359393-4765_72167.33333333333334535.0RegionG1 motif
HgeneEHD1chr11:64641893chr11:64757284ENST00000359393-4791_92167.33333333333334535.0RegionG2 motif
HgeneEHD1chr11:64641893chr11:64762021ENST00000320631-25153_156167.33333333333334535.0RegionG3 motif
HgeneEHD1chr11:64641893chr11:64762021ENST00000320631-2565_72167.33333333333334535.0RegionG1 motif
HgeneEHD1chr11:64641893chr11:64762021ENST00000320631-2591_92167.33333333333334535.0RegionG2 motif
HgeneEHD1chr11:64641893chr11:64762021ENST00000359393-47153_156167.33333333333334535.0RegionG3 motif
HgeneEHD1chr11:64641893chr11:64762021ENST00000359393-4765_72167.33333333333334535.0RegionG1 motif
HgeneEHD1chr11:64641893chr11:64762021ENST00000359393-4791_92167.33333333333334535.0RegionG2 motif
TgeneBATF2chr11:64641893chr11:64757284ENST000004358420217_800190.0DomainbZIP
TgeneBATF2chr11:64641893chr11:64762021ENST000003018870317_8013.0275.0DomainbZIP
TgeneBATF2chr11:64641893chr11:64762021ENST000004358420217_800190.0DomainbZIP
TgeneBATF2chr11:64641893chr11:64757284ENST000003018871345_6647.0275.0RegionLeucine-zipper
TgeneBATF2chr11:64641893chr11:64757284ENST000004358420220_410190.0RegionBasic motif
TgeneBATF2chr11:64641893chr11:64757284ENST000004358420245_660190.0RegionLeucine-zipper
TgeneBATF2chr11:64641893chr11:64762021ENST000003018870320_4113.0275.0RegionBasic motif
TgeneBATF2chr11:64641893chr11:64762021ENST000003018870345_6613.0275.0RegionLeucine-zipper
TgeneBATF2chr11:64641893chr11:64762021ENST000004358420220_410190.0RegionBasic motif
TgeneBATF2chr11:64641893chr11:64762021ENST000004358420245_660190.0RegionLeucine-zipper

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEHD1chr11:64641893chr11:64757284ENST00000320631-25489_500167.33333333333334535.0Calcium bindingOntology_term=ECO:0000269,ECO:0007744,ECO:0007744
HgeneEHD1chr11:64641893chr11:64757284ENST00000359393-47489_500167.33333333333334535.0Calcium bindingOntology_term=ECO:0000269,ECO:0007744,ECO:0007744
HgeneEHD1chr11:64641893chr11:64762021ENST00000320631-25489_500167.33333333333334535.0Calcium bindingOntology_term=ECO:0000269,ECO:0007744,ECO:0007744
HgeneEHD1chr11:64641893chr11:64762021ENST00000359393-47489_500167.33333333333334535.0Calcium bindingOntology_term=ECO:0000269,ECO:0007744,ECO:0007744
HgeneEHD1chr11:64641893chr11:64757284ENST00000320631-25198_227167.33333333333334535.0Coiled coilOntology_term=ECO:0000255
HgeneEHD1chr11:64641893chr11:64757284ENST00000359393-47198_227167.33333333333334535.0Coiled coilOntology_term=ECO:0000255
HgeneEHD1chr11:64641893chr11:64762021ENST00000320631-25198_227167.33333333333334535.0Coiled coilOntology_term=ECO:0000255
HgeneEHD1chr11:64641893chr11:64762021ENST00000359393-47198_227167.33333333333334535.0Coiled coilOntology_term=ECO:0000255
HgeneEHD1chr11:64641893chr11:64757284ENST00000320631-25444_532167.33333333333334535.0DomainEH
HgeneEHD1chr11:64641893chr11:64757284ENST00000320631-25476_511167.33333333333334535.0DomainEF-hand
HgeneEHD1chr11:64641893chr11:64757284ENST00000320631-2555_286167.33333333333334535.0DomainDynamin-type G
HgeneEHD1chr11:64641893chr11:64757284ENST00000359393-47444_532167.33333333333334535.0DomainEH
HgeneEHD1chr11:64641893chr11:64757284ENST00000359393-47476_511167.33333333333334535.0DomainEF-hand
HgeneEHD1chr11:64641893chr11:64757284ENST00000359393-4755_286167.33333333333334535.0DomainDynamin-type G
HgeneEHD1chr11:64641893chr11:64762021ENST00000320631-25444_532167.33333333333334535.0DomainEH
HgeneEHD1chr11:64641893chr11:64762021ENST00000320631-25476_511167.33333333333334535.0DomainEF-hand
HgeneEHD1chr11:64641893chr11:64762021ENST00000320631-2555_286167.33333333333334535.0DomainDynamin-type G
HgeneEHD1chr11:64641893chr11:64762021ENST00000359393-47444_532167.33333333333334535.0DomainEH
HgeneEHD1chr11:64641893chr11:64762021ENST00000359393-47476_511167.33333333333334535.0DomainEF-hand
HgeneEHD1chr11:64641893chr11:64762021ENST00000359393-4755_286167.33333333333334535.0DomainDynamin-type G
HgeneEHD1chr11:64641893chr11:64757284ENST00000320631-25219_222167.33333333333334535.0RegionG4 motif
HgeneEHD1chr11:64641893chr11:64757284ENST00000320631-25243_243167.33333333333334535.0RegionG5 motif
HgeneEHD1chr11:64641893chr11:64757284ENST00000359393-47219_222167.33333333333334535.0RegionG4 motif
HgeneEHD1chr11:64641893chr11:64757284ENST00000359393-47243_243167.33333333333334535.0RegionG5 motif
HgeneEHD1chr11:64641893chr11:64762021ENST00000320631-25219_222167.33333333333334535.0RegionG4 motif
HgeneEHD1chr11:64641893chr11:64762021ENST00000320631-25243_243167.33333333333334535.0RegionG5 motif
HgeneEHD1chr11:64641893chr11:64762021ENST00000359393-47219_222167.33333333333334535.0RegionG4 motif
HgeneEHD1chr11:64641893chr11:64762021ENST00000359393-47243_243167.33333333333334535.0RegionG5 motif
TgeneBATF2chr11:64641893chr11:64757284ENST000003018871317_8047.0275.0DomainbZIP
TgeneBATF2chr11:64641893chr11:64757284ENST000003018871320_4147.0275.0RegionBasic motif


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Fusion Gene Sequence for EHD1-BATF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000359393_ENST00000301887_TCGA-44-6778-01A_EHD1_chr11_64641893_-_BATF2_chr11_64757284_length(transcript)=2783nt_BP=913nt
AAAGGGGTCTGTGTGTGGCCGGGGAGGATGGCGGGGGAGTGAGCCCCATGGAACAGCCAGGAACTGATAAAAGATGAGGGGACAAAGACA
GTGTGTGTCTGGGAAGCTGGGCTGAGAGGAGGAGGTGCCGCCGCCTGGGGGTACTCCGATGCTTCCGGGGATTCCGAGCCAGCTGGAGGA
CCGCACGTGGCGAACGGCGGGCGCGGCGCGTAGTCAGGGAACCAGGGTGCCTGACTGGGTGTCTCGTGGAGCCATCCCGCGGGGGTGTGG
GGGGGCCACGGTGCCGGAAGGCGCGCGGCCCAGAGGCCGTCTCCGCCGAACGCCCGCTCCTCGCCTTCCTAACCGCAGCACTTTCGCGAG
CCTCCCTACGAGGGGCGGGGCGAAACAGCAGCCAGCCCCGTGTCCGGCAGTATGTTCAGCTGGGTCAGCAAGGATGCCCGCCGCAAGAAG
GAGCCGGAGCTCTTCCAGACGGTGGCTGAGGGGCTGCGGCAGCTGTACGCGCAGAAGCTGCTACCCCTGGAGGAGCACTACCGCTTCCAC
GAGTTCCACTCGCCCGCGCTGGAGGACGCTGACTTCGACAACAAGCCTATGGTGCTCCTCGTGGGGCAGTACAGCACGGGCAAGACCACC
TTCATCCGACACCTGATCGAGCAGGACTTCCCGGGGATGCGCATCGGGCCCGAGCCCACCACCGACTCCTTCATCGCCGTCATGCACGGC
CCCACTGAGGGCGTGGTGCCGGGCAACGCGCTCGTGGTGGACCCGCGGCGCCCCTTCCGCAAGCTCAACGCGTTTGGCAACGCTTTCCTC
AACAGGTTCATGTGTGCCCAGCTGCCCAACCCCGTCCTGGACAGCATCAGCATCATCGACACCCCCGGGATCCTGTCTGGAGAGAAGCAG
CGGATCAGCAGAGCAGCACGAGTCTCTGGAAAAAGACAACCTCGCCCTGCGGAAGGAGATCCAGTCCCTGCAGGCCGAGCTGGCGTGGTG
GAGCCGGACCCTGCACGTGCATGAGCGCCTGTGCCCCATGGATTGTGCCTCCTGCTCAGCTCCAGGGCTCCTGGGCTGCTGGGACCAGGC
TGAGGGGCTCCTGGGCCCTGGCCCACAGGGACAACATGGCTGCCGGGAGCAGCTGGAGCTGTTCCAGACCCCGGGTTCCTGTTACCCAGC
TCAGCCGCTCTCTCCAGGTCCACAGCCTCATGATTCTCCCAGCCTCCTCCAGTGCCCCCTGCCCTCACTGTCCCTTGGCCCCGCTGTGGT
TGCTGAACCTCCTGTCCAGCTGTCCCCCAGCCCTCTCCTGTTTGCCTCGCACACTGGTTCCAGCCTGCAGGGGTCTTCCTCTAAGCTCAG
TGCCCTCCAGCCCAGCCTCACGGCCCAAACTGCCCCTCCACAGCCCCTCGAGCTGGAGCATCCCACCAGAGGGAAGCTGGGGTCCTCTCC
CGACAACCCTTCCTCTGCCCTGGGGCTTGCACGTCTGCAGAGCAGGGAGCACAAACCTGCTCTCTCAGCAGCCACTTGGCAAGGGCTGGT
TGTGGATCCCAGCCCTCACCCTCTCCTGGCCTTTCCTCTGCTCTCCTCTGCTCAAGTCCACTTCTAACCTGGTCTTCGGAGCTGGGTTGG
CCCCTTCTTTGGGCTCAGGAAGCAGCCTTAGCACACGGGCCTCTCCTCCCTCACTACTGGGTGCTGCCCTGCGTGGCTGACCAGCTGGCC
CAGGATTTCACAGTCGAAAAGGAAGCCACCACTGATGCCTCCCACTGTGACAGGCCCTGTCACCACCAATATCTTATTTCAACCTCACAG
TTGACCTGAGAAATCGAGATTATCACTCCACTTTTTCAGACAAGGAAACTGAGGCTCAGGGAAGCCAAGTGACAAGTCCAAGGTCACGAA
GACTTTCTTGGAGCCCGAAACACCACCCTCTGCTCCTCCTTCTCCTGTCCTGGCCCAGGCATCCTAGGGGCTGAAATCCTGGAAACCGTG
GGCTGGTGTGAGAAGGTTTGCATGCTCAGAGCAGAGAAGGGCTCTCCCCACTGCTTCGTGATTCCAGGGCCAGAGCCATGCAGTCCCAGA
AACCCCAACCTAGCTGGGGCAGGTCCAGAGTCCAAGCCCTGGTGGGTAGAGGCCAAGCAGAAGCCCTGAAGTGGACTCTTGCTTCCCCTA
GTAGTGTTTTCAGTGCCAAGAAGCTGAAACTGTGAGCTGGAGTTGGGGAGAGGTCTGGAAGAGGACCATCTGGGATTTCTACAGCCTGGG
TACCCATAGCCACACCAAGGCTTCTGGGAGATTCTGCAGGGTCAGCTTTCCAGGCTGTTCCCAAATAGCTCCCTGCCTCCCCACTGCCCC
TAAAGCCACAGCAGAAGAGCCATTCATCTCATAAACAAAAAGGAAGAGGAAAGAATGAGGAAGGACCCTGTGCAAGGTTATTTGCAGGCA
GGGATGGGCTTGTACCTGACAGCACCCACCCCTGTGTGGCCCCCAGGCCCTCATCACCCTCAGACCCCTCCTAAGCAGTTCCCTCATTGC
TCTTTGGACTAGGCTGACAGCAGGAAGAGCAGGGCCCATGACCGGGTGGAAGTTCAGTTTTGGTGTCTGCTTCAAGAGGGGGTTTTACAC
TCTGATTCCAGGACAAGCACTCTGAGGCGGGTGGGGGAGAGAAACCCTGGCTCTTCACCCAGGTTTCACACACATGTAAATGAAACACTA

>In-frame_ENST00000359393_ENST00000301887_TCGA-44-6778-01A_EHD1_chr11_64641893_-_BATF2_chr11_64757284_length(amino acids)=290AA_start in transcript=724_stop in transcript=1596
MRAWCRATRSWWTRGAPSASSTRLATLSSTGSCVPSCPTPSWTASASSTPPGSCLERSSGSAEQHESLEKDNLALRKEIQSLQAELAWWS
RTLHVHERLCPMDCASCSAPGLLGCWDQAEGLLGPGPQGQHGCREQLELFQTPGSCYPAQPLSPGPQPHDSPSLLQCPLPSLSLGPAVVA
EPPVQLSPSPLLFASHTGSSLQGSSSKLSALQPSLTAQTAPPQPLELEHPTRGKLGSSPDNPSSALGLARLQSREHKPALSAATWQGLVV

--------------------------------------------------------------
>In-frame_ENST00000359393_ENST00000301887_TCGA-YL-A9WK-01A_EHD1_chr11_64641893_-_BATF2_chr11_64762021_length(transcript)=2885nt_BP=913nt
AAAGGGGTCTGTGTGTGGCCGGGGAGGATGGCGGGGGAGTGAGCCCCATGGAACAGCCAGGAACTGATAAAAGATGAGGGGACAAAGACA
GTGTGTGTCTGGGAAGCTGGGCTGAGAGGAGGAGGTGCCGCCGCCTGGGGGTACTCCGATGCTTCCGGGGATTCCGAGCCAGCTGGAGGA
CCGCACGTGGCGAACGGCGGGCGCGGCGCGTAGTCAGGGAACCAGGGTGCCTGACTGGGTGTCTCGTGGAGCCATCCCGCGGGGGTGTGG
GGGGGCCACGGTGCCGGAAGGCGCGCGGCCCAGAGGCCGTCTCCGCCGAACGCCCGCTCCTCGCCTTCCTAACCGCAGCACTTTCGCGAG
CCTCCCTACGAGGGGCGGGGCGAAACAGCAGCCAGCCCCGTGTCCGGCAGTATGTTCAGCTGGGTCAGCAAGGATGCCCGCCGCAAGAAG
GAGCCGGAGCTCTTCCAGACGGTGGCTGAGGGGCTGCGGCAGCTGTACGCGCAGAAGCTGCTACCCCTGGAGGAGCACTACCGCTTCCAC
GAGTTCCACTCGCCCGCGCTGGAGGACGCTGACTTCGACAACAAGCCTATGGTGCTCCTCGTGGGGCAGTACAGCACGGGCAAGACCACC
TTCATCCGACACCTGATCGAGCAGGACTTCCCGGGGATGCGCATCGGGCCCGAGCCCACCACCGACTCCTTCATCGCCGTCATGCACGGC
CCCACTGAGGGCGTGGTGCCGGGCAACGCGCTCGTGGTGGACCCGCGGCGCCCCTTCCGCAAGCTCAACGCGTTTGGCAACGCTTTCCTC
AACAGGTTCATGTGTGCCCAGCTGCCCAACCCCGTCCTGGACAGCATCAGCATCATCGACACCCCCGGGATCCTGTCTGGAGAGAAGCAG
CGGATCAGCAGAGGACCCCAAGGAGCAACAAAGGCAGCTGAAGAAGCAGAAGAACCGGGCAGCCGCCCAGCGAAGCCGGCAGAAGCACAC
AGACAAGGCAGACGCCCTGCACCAGCAGCACGAGTCTCTGGAAAAAGACAACCTCGCCCTGCGGAAGGAGATCCAGTCCCTGCAGGCCGA
GCTGGCGTGGTGGAGCCGGACCCTGCACGTGCATGAGCGCCTGTGCCCCATGGATTGTGCCTCCTGCTCAGCTCCAGGGCTCCTGGGCTG
CTGGGACCAGGCTGAGGGGCTCCTGGGCCCTGGCCCACAGGGACAACATGGCTGCCGGGAGCAGCTGGAGCTGTTCCAGACCCCGGGTTC
CTGTTACCCAGCTCAGCCGCTCTCTCCAGGTCCACAGCCTCATGATTCTCCCAGCCTCCTCCAGTGCCCCCTGCCCTCACTGTCCCTTGG
CCCCGCTGTGGTTGCTGAACCTCCTGTCCAGCTGTCCCCCAGCCCTCTCCTGTTTGCCTCGCACACTGGTTCCAGCCTGCAGGGGTCTTC
CTCTAAGCTCAGTGCCCTCCAGCCCAGCCTCACGGCCCAAACTGCCCCTCCACAGCCCCTCGAGCTGGAGCATCCCACCAGAGGGAAGCT
GGGGTCCTCTCCCGACAACCCTTCCTCTGCCCTGGGGCTTGCACGTCTGCAGAGCAGGGAGCACAAACCTGCTCTCTCAGCAGCCACTTG
GCAAGGGCTGGTTGTGGATCCCAGCCCTCACCCTCTCCTGGCCTTTCCTCTGCTCTCCTCTGCTCAAGTCCACTTCTAACCTGGTCTTCG
GAGCTGGGTTGGCCCCTTCTTTGGGCTCAGGAAGCAGCCTTAGCACACGGGCCTCTCCTCCCTCACTACTGGGTGCTGCCCTGCGTGGCT
GACCAGCTGGCCCAGGATTTCACAGTCGAAAAGGAAGCCACCACTGATGCCTCCCACTGTGACAGGCCCTGTCACCACCAATATCTTATT
TCAACCTCACAGTTGACCTGAGAAATCGAGATTATCACTCCACTTTTTCAGACAAGGAAACTGAGGCTCAGGGAAGCCAAGTGACAAGTC
CAAGGTCACGAAGACTTTCTTGGAGCCCGAAACACCACCCTCTGCTCCTCCTTCTCCTGTCCTGGCCCAGGCATCCTAGGGGCTGAAATC
CTGGAAACCGTGGGCTGGTGTGAGAAGGTTTGCATGCTCAGAGCAGAGAAGGGCTCTCCCCACTGCTTCGTGATTCCAGGGCCAGAGCCA
TGCAGTCCCAGAAACCCCAACCTAGCTGGGGCAGGTCCAGAGTCCAAGCCCTGGTGGGTAGAGGCCAAGCAGAAGCCCTGAAGTGGACTC
TTGCTTCCCCTAGTAGTGTTTTCAGTGCCAAGAAGCTGAAACTGTGAGCTGGAGTTGGGGAGAGGTCTGGAAGAGGACCATCTGGGATTT
CTACAGCCTGGGTACCCATAGCCACACCAAGGCTTCTGGGAGATTCTGCAGGGTCAGCTTTCCAGGCTGTTCCCAAATAGCTCCCTGCCT
CCCCACTGCCCCTAAAGCCACAGCAGAAGAGCCATTCATCTCATAAACAAAAAGGAAGAGGAAAGAATGAGGAAGGACCCTGTGCAAGGT
TATTTGCAGGCAGGGATGGGCTTGTACCTGACAGCACCCACCCCTGTGTGGCCCCCAGGCCCTCATCACCCTCAGACCCCTCCTAAGCAG
TTCCCTCATTGCTCTTTGGACTAGGCTGACAGCAGGAAGAGCAGGGCCCATGACCGGGTGGAAGTTCAGTTTTGGTGTCTGCTTCAAGAG
GGGGTTTTACACTCTGATTCCAGGACAAGCACTCTGAGGCGGGTGGGGGAGAGAAACCCTGGCTCTTCACCCAGGTTTCACACACATGTA
AATGAAACACTATGTTAGTATCTAACACACTCCTGGATACAGAACACAAGTCTTGGCACATATGTGATGGAAATAAAGTGTTTTGCAATC

>In-frame_ENST00000359393_ENST00000301887_TCGA-YL-A9WK-01A_EHD1_chr11_64641893_-_BATF2_chr11_64762021_length(amino acids)=324AA_start in transcript=724_stop in transcript=1698
MRAWCRATRSWWTRGAPSASSTRLATLSSTGSCVPSCPTPSWTASASSTPPGSCLERSSGSAEDPKEQQRQLKKQKNRAAAQRSRQKHTD
KADALHQQHESLEKDNLALRKEIQSLQAELAWWSRTLHVHERLCPMDCASCSAPGLLGCWDQAEGLLGPGPQGQHGCREQLELFQTPGSC
YPAQPLSPGPQPHDSPSLLQCPLPSLSLGPAVVAEPPVQLSPSPLLFASHTGSSLQGSSSKLSALQPSLTAQTAPPQPLELEHPTRGKLG

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Fusion Gene PPI Analysis for EHD1-BATF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EHD1-BATF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EHD1-BATF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneBATF2C0025202melanoma1CTD_human