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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EHHADH-ABCC5 (FusionGDB2 ID:25550)

Fusion Gene Summary for EHHADH-ABCC5

check button Fusion gene summary
Fusion gene informationFusion gene name: EHHADH-ABCC5
Fusion gene ID: 25550
HgeneTgene
Gene symbol

EHHADH

ABCC5

Gene ID

1962

10057

Gene nameenoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenaseATP binding cassette subfamily C member 5
SynonymsECHD|FRTS3|L-PBE|LBFP|LBP|PBFEABC33|EST277145|MOAT-C|MOATC|MRP5|SMRP|pABC11
Cytomap

3q27.2

3q27.1

Type of geneprotein-codingprotein-coding
Descriptionperoxisomal bifunctional enzyme3,2-trans-enoyl-CoA isomeraseL-3-hydroxyacyl-CoA dehydrogenaseL-bifunctional protein, peroxisomalPBEenoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenaseenoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenasemultidrug resistance-associated protein 5ATP-binding cassette, sub-family C (CFTR/MRP), member 5canalicular multispecific organic anion transporter Cmulti-specific organic anion transporter C
Modification date2020032720200313
UniProtAcc

Q08426

O15440

Ensembl transtripts involved in fusion geneENST00000231887, ENST00000456310, 
ENST00000475987, ENST00000440662, 
ENST00000334444, ENST00000265586, 
ENST00000492216, ENST00000427120, 
ENST00000392579, ENST00000382494, 
ENST00000446941, 
Fusion gene scores* DoF score2 X 2 X 2=86 X 7 X 6=252
# samples 29
** MAII scorelog2(2/8*10)=1.32192809488736log2(9/252*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EHHADH [Title/Abstract] AND ABCC5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEHHADH(184922204)-ABCC5(183696439), # samples:2
Anticipated loss of major functional domain due to fusion event.EHHADH-ABCC5 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
EHHADH-ABCC5 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
EHHADH-ABCC5 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEHHADH

GO:0006475

internal protein amino acid acetylation

20167786

TgeneABCC5

GO:0042908

xenobiotic transport

10840050

TgeneABCC5

GO:0140115

export across plasma membrane

10840050


check buttonFusion gene breakpoints across EHHADH (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ABCC5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A27N-01AEHHADHchr3

184922204

-ABCC5chr3

183696439

-
ChimerDB4BRCATCGA-D8-A27N-01AEHHADHchr3

184922204

-ABCC5chr3

183696439

-


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Fusion Gene ORF analysis for EHHADH-ABCC5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000231887ENST00000334444EHHADHchr3

184922204

-ABCC5chr3

183696439

-
In-frameENST00000231887ENST00000265586EHHADHchr3

184922204

-ABCC5chr3

183696439

-
5CDS-5UTRENST00000231887ENST00000492216EHHADHchr3

184922204

-ABCC5chr3

183696439

-
5CDS-intronENST00000231887ENST00000427120EHHADHchr3

184922204

-ABCC5chr3

183696439

-
5CDS-intronENST00000231887ENST00000392579EHHADHchr3

184922204

-ABCC5chr3

183696439

-
5CDS-intronENST00000231887ENST00000382494EHHADHchr3

184922204

-ABCC5chr3

183696439

-
5CDS-intronENST00000231887ENST00000446941EHHADHchr3

184922204

-ABCC5chr3

183696439

-
Frame-shiftENST00000456310ENST00000334444EHHADHchr3

184922204

-ABCC5chr3

183696439

-
Frame-shiftENST00000456310ENST00000265586EHHADHchr3

184922204

-ABCC5chr3

183696439

-
5CDS-5UTRENST00000456310ENST00000492216EHHADHchr3

184922204

-ABCC5chr3

183696439

-
5CDS-intronENST00000456310ENST00000427120EHHADHchr3

184922204

-ABCC5chr3

183696439

-
5CDS-intronENST00000456310ENST00000392579EHHADHchr3

184922204

-ABCC5chr3

183696439

-
5CDS-intronENST00000456310ENST00000382494EHHADHchr3

184922204

-ABCC5chr3

183696439

-
5CDS-intronENST00000456310ENST00000446941EHHADHchr3

184922204

-ABCC5chr3

183696439

-
intron-3CDSENST00000475987ENST00000334444EHHADHchr3

184922204

-ABCC5chr3

183696439

-
intron-3CDSENST00000475987ENST00000265586EHHADHchr3

184922204

-ABCC5chr3

183696439

-
intron-5UTRENST00000475987ENST00000492216EHHADHchr3

184922204

-ABCC5chr3

183696439

-
intron-intronENST00000475987ENST00000427120EHHADHchr3

184922204

-ABCC5chr3

183696439

-
intron-intronENST00000475987ENST00000392579EHHADHchr3

184922204

-ABCC5chr3

183696439

-
intron-intronENST00000475987ENST00000382494EHHADHchr3

184922204

-ABCC5chr3

183696439

-
intron-intronENST00000475987ENST00000446941EHHADHchr3

184922204

-ABCC5chr3

183696439

-
intron-3CDSENST00000440662ENST00000334444EHHADHchr3

184922204

-ABCC5chr3

183696439

-
intron-3CDSENST00000440662ENST00000265586EHHADHchr3

184922204

-ABCC5chr3

183696439

-
intron-5UTRENST00000440662ENST00000492216EHHADHchr3

184922204

-ABCC5chr3

183696439

-
intron-intronENST00000440662ENST00000427120EHHADHchr3

184922204

-ABCC5chr3

183696439

-
intron-intronENST00000440662ENST00000392579EHHADHchr3

184922204

-ABCC5chr3

183696439

-
intron-intronENST00000440662ENST00000382494EHHADHchr3

184922204

-ABCC5chr3

183696439

-
intron-intronENST00000440662ENST00000446941EHHADHchr3

184922204

-ABCC5chr3

183696439

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000231887EHHADHchr3184922204-ENST00000334444ABCC5chr3183696439-55199863441521372
ENST00000231887EHHADHchr3184922204-ENST00000265586ABCC5chr3183696439-41109863440231329

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000231887ENST00000334444EHHADHchr3184922204-ABCC5chr3183696439-0.000832970.9991671
ENST00000231887ENST00000265586EHHADHchr3184922204-ABCC5chr3183696439-0.0023565490.9976434

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Fusion Genomic Features for EHHADH-ABCC5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EHHADH-ABCC5


check button Go to

FGviewer for the breakpoints of chr3:184922204-chr3:183696439

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EHHADH

Q08426

ABCC5

O15440

FUNCTION: Peroxisomal trifunctional enzyme possessing 2-enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and delta 3, delta 2-enoyl-CoA isomerase activities. Catalyzes two of the four reactions of the long straight chain fatty acids peroxisomal beta-oxidation pathway. Optimal isomerase for 2,5 double bonds into 3,5 form isomerization in a range of enoyl-CoA species (Probable). Also able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species (By similarity). With HSD17B4, catalyzes the hydration of trans-2-enoyl-CoA and the dehydrogenation of 3-hydroxyacyl-CoA, but with opposite chiral specificity (PubMed:15060085). Regulates the amount of medium-chain dicarboxylic fatty acids which are essential regulators of all fatty acid oxidation pathways (By similarity). Also involved in the degradation of long-chain dicarboxylic acids through peroxisomal beta-oxidation (PubMed:15060085). {ECO:0000250|UniProtKB:P07896, ECO:0000250|UniProtKB:Q9DBM2, ECO:0000269|PubMed:15060085, ECO:0000305|PubMed:15060085}.FUNCTION: Acts as a multispecific organic anion pump which can transport nucleotide analogs. Heme transporter required for the translocation of cytosolic heme to the secretory pathway (PubMed:24836561). {ECO:0000269|PubMed:10840050, ECO:0000269|PubMed:24836561}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEHHADHchr3:184922204chr3:183696439ENST00000231887-671_282303.3333333333333724.0RegionNote=Enoyl-CoA hydratase / isomerase
TgeneABCC5chr3:184922204chr3:183696439ENST000003344447301193_1427382.33333333333331438.0DomainABC transporter 2
TgeneABCC5chr3:184922204chr3:183696439ENST00000334444730562_783382.33333333333331438.0DomainABC transporter 1
TgeneABCC5chr3:184922204chr3:183696439ENST00000334444730859_1155382.33333333333331438.0DomainABC transmembrane type-1 2
TgeneABCC5chr3:184922204chr3:183696439ENST00000382494071193_14270533.3333333333334DomainABC transporter 2
TgeneABCC5chr3:184922204chr3:183696439ENST0000038249407179_4590533.3333333333334DomainABC transmembrane type-1 1
TgeneABCC5chr3:184922204chr3:183696439ENST0000038249407562_7830533.3333333333334DomainABC transporter 1
TgeneABCC5chr3:184922204chr3:183696439ENST0000038249407859_11550533.3333333333334DomainABC transmembrane type-1 2
TgeneABCC5chr3:184922204chr3:183696439ENST00000392579061193_14270226.0DomainABC transporter 2
TgeneABCC5chr3:184922204chr3:183696439ENST0000039257906179_4590226.0DomainABC transmembrane type-1 1
TgeneABCC5chr3:184922204chr3:183696439ENST0000039257906562_7830226.0DomainABC transporter 1
TgeneABCC5chr3:184922204chr3:183696439ENST0000039257906859_11550226.0DomainABC transmembrane type-1 2
TgeneABCC5chr3:184922204chr3:183696439ENST000003344447301227_1234382.33333333333331438.0Nucleotide bindingATP 2
TgeneABCC5chr3:184922204chr3:183696439ENST00000334444730595_602382.33333333333331438.0Nucleotide bindingATP 1
TgeneABCC5chr3:184922204chr3:183696439ENST00000382494071227_12340533.3333333333334Nucleotide bindingATP 2
TgeneABCC5chr3:184922204chr3:183696439ENST0000038249407595_6020533.3333333333334Nucleotide bindingATP 1
TgeneABCC5chr3:184922204chr3:183696439ENST00000392579061227_12340226.0Nucleotide bindingATP 2
TgeneABCC5chr3:184922204chr3:183696439ENST0000039257906595_6020226.0Nucleotide bindingATP 1
TgeneABCC5chr3:184922204chr3:183696439ENST000003344447301018_1038382.33333333333331438.0TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST000003344447301104_1124382.33333333333331438.0TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST000003344447301127_1147382.33333333333331438.0TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST00000334444730400_420382.33333333333331438.0TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST00000334444730434_454382.33333333333331438.0TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST00000334444730608_628382.33333333333331438.0TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST00000334444730848_868382.33333333333331438.0TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST00000334444730917_937382.33333333333331438.0TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST00000334444730997_1017382.33333333333331438.0TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST00000382494071018_10380533.3333333333334TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST00000382494071104_11240533.3333333333334TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST00000382494071127_11470533.3333333333334TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST0000038249407179_1990533.3333333333334TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST0000038249407219_2390533.3333333333334TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST0000038249407296_3160533.3333333333334TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST0000038249407317_3370533.3333333333334TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST0000038249407400_4200533.3333333333334TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST0000038249407434_4540533.3333333333334TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST0000038249407608_6280533.3333333333334TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST0000038249407848_8680533.3333333333334TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST0000038249407917_9370533.3333333333334TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST0000038249407997_10170533.3333333333334TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST00000392579061018_10380226.0TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST00000392579061104_11240226.0TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST00000392579061127_11470226.0TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST0000039257906179_1990226.0TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST0000039257906219_2390226.0TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST0000039257906296_3160226.0TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST0000039257906317_3370226.0TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST0000039257906400_4200226.0TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST0000039257906434_4540226.0TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST0000039257906608_6280226.0TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST0000039257906848_8680226.0TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST0000039257906917_9370226.0TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST0000039257906997_10170226.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEHHADHchr3:184922204chr3:183696439ENST00000231887-67721_723303.3333333333333724.0MotifNote=Microbody targeting signal
HgeneEHHADHchr3:184922204chr3:183696439ENST00000456310-67721_723207.33333333333334628.0MotifNote=Microbody targeting signal
HgeneEHHADHchr3:184922204chr3:183696439ENST00000231887-67283_572303.3333333333333724.0RegionNote=3-hydroxyacyl-CoA dehydrogenase
HgeneEHHADHchr3:184922204chr3:183696439ENST00000456310-671_282207.33333333333334628.0RegionNote=Enoyl-CoA hydratase / isomerase
HgeneEHHADHchr3:184922204chr3:183696439ENST00000456310-67283_572207.33333333333334628.0RegionNote=3-hydroxyacyl-CoA dehydrogenase
TgeneABCC5chr3:184922204chr3:183696439ENST00000334444730179_459382.33333333333331438.0DomainABC transmembrane type-1 1
TgeneABCC5chr3:184922204chr3:183696439ENST00000334444730179_199382.33333333333331438.0TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST00000334444730219_239382.33333333333331438.0TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST00000334444730296_316382.33333333333331438.0TransmembraneHelical
TgeneABCC5chr3:184922204chr3:183696439ENST00000334444730317_337382.33333333333331438.0TransmembraneHelical


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Fusion Gene Sequence for EHHADH-ABCC5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000231887_ENST00000334444_TCGA-D8-A27N-01A_EHHADH_chr3_184922204_-_ABCC5_chr3_183696439_length(transcript)=5519nt_BP=986nt
GAGGAGGCCGGGCGCGCCCGGAAAAGTGGTTTGCCTGACGGCGAGAGGCAGAGGTGCCCTCGGTGATAGAGGAAACATGGCCGAGTATAC
GCGGCTGCACAACGCCTTGGCGCTAATCCGCCTCCGAAACCCGCCGGTCAACGCGATCAGTACGACTTTACTCCGTGACATAAAAGAAGG
ACTACAGAAAGCTGTAATAGACCATACAATAAAAGCCATTGTGATTTGTGGAGCAGAGGGCAAATTTTCTGCAGGTGCTGATATTCGTGG
CTTCAGTGCTCCTAGGACATTTGGCCTTACACTGGGACATGTAGTAGATGAAATACAGAGAAATGAGAAGCCCGTGGTGGCAGCAATCCA
AGGCATGGCTTTCGGAGGGGGACTAGAGCTGGCCCTGGGCTGTCACTATAGGATTGCCCACGCAGAGGCTCAAGTTGGCTTACCAGAAGT
TACACTGGGACTTCTCCCTGGTGCAAGAGGAACCCAGCTTCTCCCCAGACTCACTGGAGTTCCTGCTGCACTTGACTTAATTACCTCAGG
AAGACGTATTTTAGCAGATGAAGCACTCAAGCTGGGCATTCTAGATAAAGTTGTAAACTCAGACCCGGTTGAAGAAGCAATCAGATTTGC
TCAGAGAGTTTCAGATCAACCTCTAGAATCCCGTAGACTCTGCAACAAGCCAATTCAGAGCTTGCCCAACATGGACAGCATTTTTAGTGA
GGCCCTCTTGAAGATGCGGAGGCAGCACCCTGGGTGTCTTGCACAGGAGGCTTGTGTCCGTGCAGTCCAGGCTGCTGTGCAGTATCCCTA
TGAAGTGGGCATCAAGAAGGAGGAGGAGCTGTTTCTATATCTTTTGCAATCAGGGCAGGCTAGAGCCCTGCAATATGCTTTCTTCGCTGA
AAGGAAAGCAAATAAGTGGTCAACTCCCTCCGGAGCATCGTGGAAAACAGCATCAGCGCGGCCTGTCTCCTCAGTTGGTGTTGTTGAAAT
CCGCGAGGAGGAGCGTCGGATATTGGAAAAAGCTGGGTACTTCCAGAGCATCACTGTGGGTGTGGCTCCCATTGTGGTGGTGATTGCCAG
CGTGGTGACCTTCTCTGTTCATATGACCCTGGGCTTCGATCTGACAGCAGCACAGGCTTTCACAGTGGTGACAGTCTTCAATTCCATGAC
TTTTGCTTTGAAAGTAACACCGTTTTCAGTAAAGTCCCTCTCAGAAGCCTCAGTGGCTGTTGACAGATTTAAGAGTTTGTTTCTAATGGA
AGAGGTTCACATGATAAAGAACAAACCAGCCAGTCCTCACATCAAGATAGAGATGAAAAATGCCACCTTGGCATGGGACTCCTCCCACTC
CAGTATCCAGAACTCGCCCAAGCTGACCCCCAAAATGAAAAAAGACAAGAGGGCTTCCAGGGGCAAGAAAGAGAAGGTGAGGCAGCTGCA
GCGCACTGAGCATCAGGCGGTGCTGGCAGAGCAGAAAGGCCACCTCCTCCTGGACAGTGACGAGCGGCCCAGTCCCGAAGAGGAAGAAGG
CAAGCACATCCACCTGGGCCACCTGCGCTTACAGAGGACACTGCACAGCATCGATCTGGAGATCCAAGAGGGTAAACTGGTTGGAATCTG
TGGCAGTGTGGGAAGTGGAAAAACCTCTCTCATTTCAGCCATTTTAGGCCAGATGACGCTTCTAGAGGGCAGCATTGCAATCAGTGGAAC
CTTCGCTTATGTGGCCCAGCAGGCCTGGATCCTCAATGCTACTCTGAGAGACAACATCCTGTTTGGGAAGGAATATGATGAAGAAAGATA
CAACTCTGTGCTGAACAGCTGCTGCCTGAGGCCTGACCTGGCCATTCTTCCCAGCAGCGACCTGACGGAGATTGGAGAGCGAGGAGCCAA
CCTGAGCGGTGGGCAGCGCCAGAGGATCAGCCTTGCCCGGGCCTTGTATAGTGACAGGAGCATCTACATCCTGGACGACCCCCTCAGTGC
CTTAGATGCCCATGTGGGCAACCACATCTTCAATAGTGCTATCCGGAAACATCTCAAGTCCAAGACAGTTCTGTTTGTTACCCACCAGTT
ACAGTACCTGGTTGACTGTGATGAAGTGATCTTCATGAAAGAGGGCTGTATTACGGAAAGAGGCACCCATGAGGAACTGATGAATTTAAA
TGGTGACTATGCTACCATTTTTAATAACCTGTTGCTGGGAGAGACACCGCCAGTTGAGATCAATTCAAAAAAGGAAACCAGTGGTTCACA
GAAGAAGTCACAAGACAAGGGTCCTAAAACAGGATCAGTAAAGAAGGAAAAAGCAGTAAAGCCAGAGGAAGGGCAGCTTGTGCAGCTGGA
AGAGAAAGGGCAGGGTTCAGTGCCCTGGTCAGTATATGGTGTCTACATCCAGGCTGCTGGGGGCCCCTTGGCATTCCTGGTTATTATGGC
CCTTTTCATGCTGAATGTAGGCAGCACCGCCTTCAGCACCTGGTGGTTGAGTTACTGGATCAAGCAAGGAAGCGGGAACACCACTGTGAC
TCGAGGGAACGAGACCTCGGTGAGTGACAGCATGAAGGACAATCCTCATATGCAGTACTATGCCAGCATCTACGCCCTCTCCATGGCAGT
CATGCTGATCCTGAAAGCCATTCGAGGAGTTGTCTTTGTCAAGGGCACGCTGCGAGCTTCCTCCCGGCTGCATGACGAGCTTTTCCGAAG
GATCCTTCGAAGCCCTATGAAGTTTTTTGACACGACCCCCACAGGGAGGATTCTCAACAGGTTTTCCAAAGACATGGATGAAGTTGACGT
GCGGCTGCCGTTCCAGGCCGAGATGTTCATCCAGAACGTTATCCTGGTGTTCTTCTGTGTGGGAATGATCGCAGGAGTCTTCCCGTGGTT
CCTTGTGGCAGTGGGGCCCCTTGTCATCCTCTTTTCAGTCCTGCACATTGTCTCCAGGGTCCTGATTCGGGAGCTGAAGCGTCTGGACAA
TATCACGCAGTCACCTTTCCTCTCCCACATCACGTCCAGCATACAGGGCCTTGCCACCATCCACGCCTACAATAAAGGGCAGGAGTTTCT
GCACAGATACCAGGAGCTGCTGGATGACAACCAAGCTCCTTTTTTTTTGTTTACGTGTGCGATGCGGTGGCTGGCTGTGCGGCTGGACCT
CATCAGCATCGCCCTCATCACCACCACGGGGCTGATGATCGTTCTTATGCACGGGCAGATTCCCCCAGCCTATGCGGGTCTCGCCATCTC
TTATGCTGTCCAGTTAACGGGGCTGTTCCAGTTTACGGTCAGACTGGCATCTGAGACAGAAGCTCGATTCACCTCGGTGGAGAGGATCAA
TCACTACATTAAGACTCTGTCCTTGGAAGCACCTGCCAGAATTAAGAACAAGGCTCCCTCCCCTGACTGGCCCCAGGAGGGAGAGGTGAC
CTTTGAGAACGCAGAGATGAGGTACCGAGAAAACCTCCCTCTCGTCCTAAAGAAAGTATCCTTCACGATCAAACCTAAAGAGAAGATTGG
CATTGTGGGGCGGACAGGATCAGGGAAGTCCTCGCTGGGGATGGCCCTCTTCCGTCTGGTGGAGTTATCTGGAGGCTGCATCAAGATTGA
TGGAGTGAGAATCAGTGATATTGGCCTTGCCGACCTCCGAAGCAAACTCTCTATCATTCCTCAAGAGCCGGTGCTGTTCAGTGGCACTGT
CAGATCAAATTTGGACCCCTTCAACCAGTACACTGAAGACCAGATTTGGGATGCCCTGGAGAGGACACACATGAAAGAATGTATTGCTCA
GCTACCTCTGAAACTTGAATCTGAAGTGATGGAGAATGGGGATAACTTCTCAGTGGGGGAACGGCAGCTCTTGTGCATAGCTAGAGCCCT
GCTCCGCCACTGTAAGATTCTGATTTTAGATGAAGCCACAGCTGCCATGGACACAGAGACAGACTTATTGATTCAAGAGACCATCCGAGA
AGCATTTGCAGACTGTACCATGCTGACCATTGCCCATCGCCTGCACACGGTTCTAGGCTCCGATAGGATTATGGTGCTGGCCCAGGGACA
GGTGGTGGAGTTTGACACCCCATCGGTCCTTCTGTCCAACGACAGTTCCCGATTCTATGCCATGTTTGCTGCTGCAGAGAACAAGGTCGC
TGTCAAGGGCTGACTCCTCCCTGTTGACGAAGTCTCTTTTCTTTAGAGCATTGCCATTCCCTGCCTGGGGCGGGCCCCTCATCGCGTCCT
CCTACCGAAACCTTGCCTTTCTCGATTTTATCTTTCGCACAGCAGTTCCGGATTGGCTTGTGTGTTTCACTTTTAGGGAGAGTCATATTT
TGATTATTGTATTTATTCCATATTCATGTAAACAAAATTTAGTTTTTGTTCTTAATTGCACTCTAAAAGGTTCAGGGAACCGTTATTATA
ATTGTATCAGAGGCCTATAATGAAGCTTTATACGTGTAGCTATATCTATATATAATTCTGTACATAGCCTATATTTACAGTGAAAATGTA
AGCTGTTTATTTTATATTAAAATAAGCACTGTGCTAATAACAGTGCATATTCCTTTCTATCATTTTTGTACAGTTTGCTGTACTAGAGAT
CTGGTTTTGCTATTAGACTGTAGGAAGAGTAGCATTTCATTCTTCTCTAGCTGGTGGTTTCACGGTGCCAGGTTTTCTGGGTGTCCAAAG
GAAGACGTGTGGCAATAGTGGGCCCTCCGACAGCCCCCTCTGCCGCCTCCCCACGGCCGCTCCAGGGGTGGCTGGAGACGGGTGGGCGGC
TGGAGACCATGCAGAGCGCCGTGAGTTCTCAGGGCTCCTGCCTTCTGTCCTGGTGTCACTTACTGTTTCTGTCAGGAGAGCAGCGGGGCG
AAGCCCAGGCCCCTTTTCACTCCCTCCATCAAGAATGGGGATCACAGAGACATTCCTCCGAGCCGGGGAGTTTCTTTCCTGCCTTCTTCT
TTTTGCTGTTGTTTCTAAACAAGAATCAGTCTATCCACAGAGAGTCCCACTGCCTCAGGTTCCTATGGCTGGCCACTGCACAGAGCTCTC
CAGCTCCAAGACCTGTTGGTTCCAAGCCCTGGAGCCAACTGCTGCTTTTTGAGGTGGCACTTTTTCATTTGCCTATTCCCACACCTCCAC
AGTTCAGTGGCAGGGCTCAGGATTTCGTGGGTCTGTTTTCCTTTCTCACCGCAGTCGTCGCACAGTCTCTCTCTCTCTCTCCCCTCAAAG
TCTGCAACTTTAAGCAGCTCTTGCTAATCAGTGTCTCACACTGGCGTAGAAGTTTTTGTACTGTAAAGAGACCTACCTCAGGTTGCTGGT
TGCTGTGTGGTTTGGTGTGTTCCCGCAAACCCCCTTTGTGCTGTGGGGCTGGTAGCTCAGGTGGGCGTGGTCACTGCTGTCATCAATTGA
ATGGTCAGCGTTGCATGTCGTGACCAACTAGACATTCTGTCGCCTTAGCATGTTTGCTGAACACCTTGTGGAAGCAAAAATCTGAAAATG

>In-frame_ENST00000231887_ENST00000334444_TCGA-D8-A27N-01A_EHHADH_chr3_184922204_-_ABCC5_chr3_183696439_length(amino acids)=1372AA_start in transcript=34_stop in transcript=4152
MTARGRGALGDRGNMAEYTRLHNALALIRLRNPPVNAISTTLLRDIKEGLQKAVIDHTIKAIVICGAEGKFSAGADIRGFSAPRTFGLTL
GHVVDEIQRNEKPVVAAIQGMAFGGGLELALGCHYRIAHAEAQVGLPEVTLGLLPGARGTQLLPRLTGVPAALDLITSGRRILADEALKL
GILDKVVNSDPVEEAIRFAQRVSDQPLESRRLCNKPIQSLPNMDSIFSEALLKMRRQHPGCLAQEACVRAVQAAVQYPYEVGIKKEEELF
LYLLQSGQARALQYAFFAERKANKWSTPSGASWKTASARPVSSVGVVEIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLG
FDLTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPK
MKKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLI
SAILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISL
ARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLL
LGETPPVEINSKKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAF
STWWLSYWIKQGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDT
TPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPFLSHIT
SSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQF
TVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSS
LGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVME
NGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLL

--------------------------------------------------------------
>In-frame_ENST00000231887_ENST00000265586_TCGA-D8-A27N-01A_EHHADH_chr3_184922204_-_ABCC5_chr3_183696439_length(transcript)=4110nt_BP=986nt
GAGGAGGCCGGGCGCGCCCGGAAAAGTGGTTTGCCTGACGGCGAGAGGCAGAGGTGCCCTCGGTGATAGAGGAAACATGGCCGAGTATAC
GCGGCTGCACAACGCCTTGGCGCTAATCCGCCTCCGAAACCCGCCGGTCAACGCGATCAGTACGACTTTACTCCGTGACATAAAAGAAGG
ACTACAGAAAGCTGTAATAGACCATACAATAAAAGCCATTGTGATTTGTGGAGCAGAGGGCAAATTTTCTGCAGGTGCTGATATTCGTGG
CTTCAGTGCTCCTAGGACATTTGGCCTTACACTGGGACATGTAGTAGATGAAATACAGAGAAATGAGAAGCCCGTGGTGGCAGCAATCCA
AGGCATGGCTTTCGGAGGGGGACTAGAGCTGGCCCTGGGCTGTCACTATAGGATTGCCCACGCAGAGGCTCAAGTTGGCTTACCAGAAGT
TACACTGGGACTTCTCCCTGGTGCAAGAGGAACCCAGCTTCTCCCCAGACTCACTGGAGTTCCTGCTGCACTTGACTTAATTACCTCAGG
AAGACGTATTTTAGCAGATGAAGCACTCAAGCTGGGCATTCTAGATAAAGTTGTAAACTCAGACCCGGTTGAAGAAGCAATCAGATTTGC
TCAGAGAGTTTCAGATCAACCTCTAGAATCCCGTAGACTCTGCAACAAGCCAATTCAGAGCTTGCCCAACATGGACAGCATTTTTAGTGA
GGCCCTCTTGAAGATGCGGAGGCAGCACCCTGGGTGTCTTGCACAGGAGGCTTGTGTCCGTGCAGTCCAGGCTGCTGTGCAGTATCCCTA
TGAAGTGGGCATCAAGAAGGAGGAGGAGCTGTTTCTATATCTTTTGCAATCAGGGCAGGCTAGAGCCCTGCAATATGCTTTCTTCGCTGA
AAGGAAAGCAAATAAGTGGTCAACTCCCTCCGGAGCATCGTGGAAAACAGCATCAGCGCGGCCTGTCTCCTCAGTTGGTGTTGTTGAAAT
CCGCGAGGAGGAGCGTCGGATATTGGAAAAAGCTGGGTACTTCCAGAGCATCACTGTGGGTGTGGCTCCCATTGTGGTGGTGATTGCCAG
CGTGGTGACCTTCTCTGTTCATATGACCCTGGGCTTCGATCTGACAGCAGCACAGGCTTTCACAGTGGTGACAGTCTTCAATTCCATGAC
TTTTGCTTTGAAAGTAACACCGTTTTCAGTAAAGTCCCTCTCAGAAGCCTCAGTGGCTGTTGACAGATTTAAGAGTTTGTTTCTAATGGA
AGAGGTTCACATGATAAAGAACAAACCAGCCAGTCCTCACATCAAGATAGAGATGAAAAATGCCACCTTGGCATGGGACTCCTCCCACTC
CAGTATCCAGAACTCGCCCAAGCTGACCCCCAAAATGAAAAAAGACAAGAGGGCTTCCAGGGGCAAGAAAGAGAAGGTGAGGCAGCTGCA
GCGCACTGAGCATCAGGCGGTGCTGGCAGAGCAGAAAGGCCACCTCCTCCTGGACAGTGACGAGCGGCCCAGTCCCGAAGAGGAAGAAGG
CAAGCACATCCACCTGGGCCACCTGCGCTTACAGAGGACACTGCACAGCATCGATCTGGAGATCCAAGAGGGTAAACTGGTTGGAATCTG
TGGCAGTGTGGGAAGTGGAAAAACCTCTCTCATTTCAGCCATTTTAGGCCAGATGACGCTTCTAGAGGGCAGCATTGCAATCAGTGGAAC
CTTCGCTTATGTGGCCCAGCAGGCCTGGATCCTCAATGCTACTCTGAGAGACAACATCCTGTTTGGGAAGGAATATGATGAAGAAAGATA
CAACTCTGTGCTGAACAGCTGCTGCCTGAGGCCTGACCTGGCCATTCTTCCCAGCAGCGACCTGACGGAGATTGGAGAGCGAGGAGCCAA
CCTGAGCGGTGGGCAGCGCCAGAGGATCAGCCTTGCCCGGGCCTTGTATAGTGACAGGAGCATCTACATCCTGGACGACCCCCTCAGTGC
CTTAGATGCCCATGTGGGCAACCACATCTTCAATAGTGCTATCCGGAAACATCTCAAGTCCAAGACAGTTCTGTTTGTTACCCACCAGTT
ACAGTACCTGGTTGACTGTGATGAAGTGATCTTCATGAAAGAGGGCTGTATTACGGAAAGAGGCACCCATGAGGAACTGATGAATTTAAA
TGGTGACTATGCTACCATTTTTAATAACCTGTTGCTGGGAGAGACACCGCCAGTTGAGATCAATTCAAAAAAGGAAACCAGTGGTTCACA
GAAGAAGTCACAAGACAAGGGTCCTAAAACAGGATCAGTAAAGAAGGAAAAAGCAGTAAAGCCAGAGGAAGGGCAGCTTGTGCAGCTGGA
AGAGAAAGGGCAGGGTTCAGTGCCCTGGTCAGTATATGGTGTCTACATCCAGGCTGCTGGGGGCCCCTTGGCATTCCTGGTTATTATGGC
CCTTTTCATGCTGAATGTAGGCAGCACCGCCTTCAGCACCTGGTGGTTGAGTTACTGGATCAAGCAAGGAAGCGGGAACACCACTGTGAC
TCGAGGGAACGAGACCTCGGTGAGTGACAGCATGAAGGACAATCCTCATATGCAGTACTATGCCAGCATCTACGCCCTCTCCATGGCAGT
CATGCTGATCCTGAAAGCCATTCGAGGAGTTGTCTTTGTCAAGGGCACGCTGCGAGCTTCCTCCCGGCTGCATGACGAGCTTTTCCGAAG
GATCCTTCGAAGCCCTATGAAGTTTTTTGACACGACCCCCACAGGGAGGATTCTCAACAGGTTTTCCAAAGACATGGATGAAGTTGACGT
GCGGCTGCCGTTCCAGGCCGAGATGTTCATCCAGAACGTTATCCTGGTGTTCTTCTGTGTGGGAATGATCGCAGGAGTCTTCCCGTGGTT
CCTTGTGGCAGTGGGGCCCCTTGTCATCCTCTTTTCAGTCCTGCACATTGTCTCCAGATACCAGGAGCTGCTGGATGACAACCAAGCTCC
TTTTTTTTTGTTTACGTGTGCGATGCGGTGGCTGGCTGTGCGGCTGGACCTCATCAGCATCGCCCTCATCACCACCACGGGGCTGATGAT
CGTTCTTATGCACGGGCAGATTCCCCCAGCCTATGCGGGTCTCGCCATCTCTTATGCTGTCCAGTTAACGGGGCTGTTCCAGTTTACGGT
CAGACTGGCATCTGAGACAGAAGCTCGATTCACCTCGGTGGAGAGGATCAATCACTACATTAAGACTCTGTCCTTGGAAGCACCTGCCAG
AATTAAGAACAAGGCTCCCTCCCCTGACTGGCCCCAGGAGGGAGAGGTGACCTTTGAGAACGCAGAGATGAGGTACCGAGAAAACCTCCC
TCTCGTCCTAAAGAAAGTATCCTTCACGATCAAACCTAAAGAGAAGATTGGCATTGTGGGGCGGACAGGATCAGGGAAGTCCTCGCTGGG
GATGGCCCTCTTCCGTCTGGTGGAGTTATCTGGAGGCTGCATCAAGATTGATGGAGTGAGAATCAGTGATATTGGCCTTGCCGACCTCCG
AAGCAAACTCTCTATCATTCCTCAAGAGCCGGTGCTGTTCAGTGGCACTGTCAGATCAAATTTGGACCCCTTCAACCAGTACACTGAAGA
CCAGATTTGGGATGCCCTGGAGAGGACACACATGAAAGAATGTATTGCTCAGCTACCTCTGAAACTTGAATCTGAAGTGATGGAGAATGG
GGATAACTTCTCAGTGGGGGAACGGCAGCTCTTGTGCATAGCTAGAGCCCTGCTCCGCCACTGTAAGATTCTGATTTTAGATGAAGCCAC
AGCTGCCATGGACACAGAGACAGACTTATTGATTCAAGAGACCATCCGAGAAGCATTTGCAGACTGTACCATGCTGACCATTGCCCATCG
CCTGCACACGGTTCTAGGCTCCGATAGGATTATGGTGCTGGCCCAGGGACAGGTGGTGGAGTTTGACACCCCATCGGTCCTTCTGTCCAA
CGACAGTTCCCGATTCTATGCCATGTTTGCTGCTGCAGAGAACAAGGTCGCTGTCAAGGGCTGACTCCTCCCTGTTGACGAAGTCTCTTT

>In-frame_ENST00000231887_ENST00000265586_TCGA-D8-A27N-01A_EHHADH_chr3_184922204_-_ABCC5_chr3_183696439_length(amino acids)=1329AA_start in transcript=34_stop in transcript=4023
MTARGRGALGDRGNMAEYTRLHNALALIRLRNPPVNAISTTLLRDIKEGLQKAVIDHTIKAIVICGAEGKFSAGADIRGFSAPRTFGLTL
GHVVDEIQRNEKPVVAAIQGMAFGGGLELALGCHYRIAHAEAQVGLPEVTLGLLPGARGTQLLPRLTGVPAALDLITSGRRILADEALKL
GILDKVVNSDPVEEAIRFAQRVSDQPLESRRLCNKPIQSLPNMDSIFSEALLKMRRQHPGCLAQEACVRAVQAAVQYPYEVGIKKEEELF
LYLLQSGQARALQYAFFAERKANKWSTPSGASWKTASARPVSSVGVVEIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLG
FDLTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPK
MKKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLI
SAILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISL
ARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLL
LGETPPVEINSKKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAF
STWWLSYWIKQGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDT
TPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRYQELLDDNQAPFFLFTCAMRWL
AVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWP
QEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPV
LFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for EHHADH-ABCC5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EHHADH-ABCC5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneEHHADHQ08426DB00157NADHSmall moleculeApproved|Nutraceutical
HgeneEHHADHQ08426DB00157NADHSmall moleculeApproved|Nutraceutical
TgeneABCC5O15440DB11672CurcuminInhibitorSmall moleculeApproved|Experimental|Investigational
TgeneABCC5O15440DB11672CurcuminInhibitorSmall moleculeApproved|Experimental|Investigational

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Related Diseases for EHHADH-ABCC5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEHHADHC0005586Bipolar Disorder1PSYGENET
HgeneEHHADHC0013146Drug abuse1CTD_human
HgeneEHHADHC0013170Drug habituation1CTD_human
HgeneEHHADHC0013222Drug Use Disorders1CTD_human
HgeneEHHADHC0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgeneEHHADHC0033578Prostatic Neoplasms1CTD_human
HgeneEHHADHC0038580Substance Dependence1CTD_human
HgeneEHHADHC0038586Substance Use Disorders1CTD_human
HgeneEHHADHC0236969Substance-Related Disorders1CTD_human
HgeneEHHADHC0341703Adult Fanconi syndrome1CTD_human;ORPHANET
HgeneEHHADHC0342870Bifunctional peroxisomal enzyme deficiency1ORPHANET
HgeneEHHADHC0376358Malignant neoplasm of prostate1CTD_human
HgeneEHHADHC0740858Substance abuse problem1CTD_human
HgeneEHHADHC1510472Drug Dependence1CTD_human
HgeneEHHADHC3810100FANCONI RENOTUBULAR SYNDROME 31GENOMICS_ENGLAND;UNIPROT
HgeneEHHADHC4316881Prescription Drug Abuse1CTD_human
HgeneEHHADHC4551503FANCONI RENOTUBULAR SYNDROME 11ORPHANET
TgeneABCC5C0003873Rheumatoid Arthritis1CTD_human
TgeneABCC5C0009402Colorectal Carcinoma1CTD_human
TgeneABCC5C0009404Colorectal Neoplasms1CTD_human
TgeneABCC5C0023893Liver Cirrhosis, Experimental1CTD_human