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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EIF3M-CSTF3 (FusionGDB2 ID:25885)

Fusion Gene Summary for EIF3M-CSTF3

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF3M-CSTF3
Fusion gene ID: 25885
HgeneTgene
Gene symbol

EIF3M

CSTF3

Gene ID

10480

1479

Gene nameeukaryotic translation initiation factor 3 subunit Mcleavage stimulation factor subunit 3
SynonymsB5|GA17|PCID1|TANGO7|hfl-B5CSTF-77
Cytomap

11p13

11p13

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic translation initiation factor 3 subunit MB5 receptorPCI domain containing 1 (herpesvirus entry mediator)PCI domain-containing protein 1dendritic cell proteinfetal lung protein B5transport and golgi organization 7 homologcleavage stimulation factor subunit 3CF-1 77 kDa subunitCSTF 77 kDa subunitcleavage stimulation factor 77 kDa subunitcleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDcleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
Modification date2020031320200313
UniProtAcc

Q7L2H7

Q12996

Ensembl transtripts involved in fusion geneENST00000531120, ENST00000524896, 
ENST00000532054, 		ENST00000323959, 
ENST00000524827, ENST00000526480, 
ENST00000438862, ENST00000431742, 
Fusion gene scores* DoF score9 X 9 X 4=3247 X 4 X 6=168
# samples 108
** MAII scorelog2(10/324*10)=-1.6959938131099
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EIF3M [Title/Abstract] AND CSTF3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEIF3M(32605475)-CSTF3(33163532), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across EIF3M (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CSTF3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-57-1993-01AEIF3Mchr11

32605475

+CSTF3chr11

33163532

-
ChimerDB4OVTCGA-57-1993-01AEIF3Mchr11

32605475

+CSTF3chr11

33163532

-


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Fusion Gene ORF analysis for EIF3M-CSTF3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000531120ENST00000323959EIF3Mchr11

32605475

+CSTF3chr11

33163532

-
In-frameENST00000531120ENST00000524827EIF3Mchr11

32605475

+CSTF3chr11

33163532

-
5CDS-5UTRENST00000531120ENST00000526480EIF3Mchr11

32605475

+CSTF3chr11

33163532

-
5CDS-5UTRENST00000531120ENST00000438862EIF3Mchr11

32605475

+CSTF3chr11

33163532

-
5CDS-5UTRENST00000531120ENST00000431742EIF3Mchr11

32605475

+CSTF3chr11

33163532

-
In-frameENST00000524896ENST00000323959EIF3Mchr11

32605475

+CSTF3chr11

33163532

-
In-frameENST00000524896ENST00000524827EIF3Mchr11

32605475

+CSTF3chr11

33163532

-
5CDS-5UTRENST00000524896ENST00000526480EIF3Mchr11

32605475

+CSTF3chr11

33163532

-
5CDS-5UTRENST00000524896ENST00000438862EIF3Mchr11

32605475

+CSTF3chr11

33163532

-
5CDS-5UTRENST00000524896ENST00000431742EIF3Mchr11

32605475

+CSTF3chr11

33163532

-
intron-3CDSENST00000532054ENST00000323959EIF3Mchr11

32605475

+CSTF3chr11

33163532

-
intron-3CDSENST00000532054ENST00000524827EIF3Mchr11

32605475

+CSTF3chr11

33163532

-
intron-5UTRENST00000532054ENST00000526480EIF3Mchr11

32605475

+CSTF3chr11

33163532

-
intron-5UTRENST00000532054ENST00000438862EIF3Mchr11

32605475

+CSTF3chr11

33163532

-
intron-5UTRENST00000532054ENST00000431742EIF3Mchr11

32605475

+CSTF3chr11

33163532

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000531120EIF3Mchr1132605475+ENST00000323959CSTF3chr1133163532-2735105632231722
ENST00000531120EIF3Mchr1132605475+ENST00000524827CSTF3chr1133163532-54010563539158
ENST00000524896EIF3Mchr1132605475+ENST00000323959CSTF3chr1133163532-272696542222722
ENST00000524896EIF3Mchr1132605475+ENST00000524827CSTF3chr1133163532-5319654530158

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000531120ENST00000323959EIF3Mchr1132605475+CSTF3chr1133163532-0.0002765940.9997234
ENST00000531120ENST00000524827EIF3Mchr1132605475+CSTF3chr1133163532-0.0020382350.99796176
ENST00000524896ENST00000323959EIF3Mchr1132605475+CSTF3chr1133163532-0.0002876480.9997123
ENST00000524896ENST00000524827EIF3Mchr1132605475+CSTF3chr1133163532-0.0022062820.9977937

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Fusion Genomic Features for EIF3M-CSTF3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EIF3M-CSTF3


check button Go to

FGviewer for the breakpoints of chr11:32605475-chr11:33163532

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF3M

Q7L2H7

CSTF3

Q12996

FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17403899, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17403899). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03012, ECO:0000269|PubMed:17403899, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.; FUNCTION: (Microbial infection) May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2). {ECO:0000269|PubMed:15919898}.FUNCTION: One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCSTF3chr11:32605475chr11:33163532ENST00000323959021559_6269.0718.0Compositional biasNote=Pro-rich
TgeneCSTF3chr11:32605475chr11:33163532ENST0000043174202559_6269.045.0Compositional biasNote=Pro-rich
TgeneCSTF3chr11:32605475chr11:33163532ENST0000043886203559_6269.0104.0Compositional biasNote=Pro-rich
TgeneCSTF3chr11:32605475chr11:33163532ENST00000323959021117_1529.0718.0RepeatNote=HAT 3
TgeneCSTF3chr11:32605475chr11:33163532ENST00000323959021163_1969.0718.0RepeatNote=HAT 4
TgeneCSTF3chr11:32605475chr11:33163532ENST00000323959021221_2619.0718.0RepeatNote=HAT 5
TgeneCSTF3chr11:32605475chr11:33163532ENST00000323959021271_3039.0718.0RepeatNote=HAT 6
TgeneCSTF3chr11:32605475chr11:33163532ENST00000323959021319_3529.0718.0RepeatNote=HAT 7
TgeneCSTF3chr11:32605475chr11:33163532ENST00000323959021354_3879.0718.0RepeatNote=HAT 8
TgeneCSTF3chr11:32605475chr11:33163532ENST00000323959021458_4949.0718.0RepeatNote=HAT 9
TgeneCSTF3chr11:32605475chr11:33163532ENST0000032395902145_779.0718.0RepeatNote=HAT 1
TgeneCSTF3chr11:32605475chr11:33163532ENST0000032395902179_1109.0718.0RepeatNote=HAT 2
TgeneCSTF3chr11:32605475chr11:33163532ENST0000043174202117_1529.045.0RepeatNote=HAT 3
TgeneCSTF3chr11:32605475chr11:33163532ENST0000043174202163_1969.045.0RepeatNote=HAT 4
TgeneCSTF3chr11:32605475chr11:33163532ENST0000043174202221_2619.045.0RepeatNote=HAT 5
TgeneCSTF3chr11:32605475chr11:33163532ENST0000043174202271_3039.045.0RepeatNote=HAT 6
TgeneCSTF3chr11:32605475chr11:33163532ENST0000043174202319_3529.045.0RepeatNote=HAT 7
TgeneCSTF3chr11:32605475chr11:33163532ENST0000043174202354_3879.045.0RepeatNote=HAT 8
TgeneCSTF3chr11:32605475chr11:33163532ENST0000043174202458_4949.045.0RepeatNote=HAT 9
TgeneCSTF3chr11:32605475chr11:33163532ENST000004317420245_779.045.0RepeatNote=HAT 1
TgeneCSTF3chr11:32605475chr11:33163532ENST000004317420279_1109.045.0RepeatNote=HAT 2
TgeneCSTF3chr11:32605475chr11:33163532ENST0000043886203117_1529.0104.0RepeatNote=HAT 3
TgeneCSTF3chr11:32605475chr11:33163532ENST0000043886203163_1969.0104.0RepeatNote=HAT 4
TgeneCSTF3chr11:32605475chr11:33163532ENST0000043886203221_2619.0104.0RepeatNote=HAT 5
TgeneCSTF3chr11:32605475chr11:33163532ENST0000043886203271_3039.0104.0RepeatNote=HAT 6
TgeneCSTF3chr11:32605475chr11:33163532ENST0000043886203319_3529.0104.0RepeatNote=HAT 7
TgeneCSTF3chr11:32605475chr11:33163532ENST0000043886203354_3879.0104.0RepeatNote=HAT 8
TgeneCSTF3chr11:32605475chr11:33163532ENST0000043886203458_4949.0104.0RepeatNote=HAT 9
TgeneCSTF3chr11:32605475chr11:33163532ENST000004388620345_779.0104.0RepeatNote=HAT 1
TgeneCSTF3chr11:32605475chr11:33163532ENST000004388620379_1109.0104.0RepeatNote=HAT 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEIF3Mchr11:32605475chr11:33163532ENST00000531120+111180_33914.0375.0DomainPCI


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Fusion Gene Sequence for EIF3M-CSTF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000531120_ENST00000323959_TCGA-57-1993-01A_EIF3M_chr11_32605475_+_CSTF3_chr11_33163532_length(transcript)=2735nt_BP=105nt
AGTTCCCTTTTCCGGTCGGCGTGGTCTTGCGAGTGGAGTGTCCGCTGTGCCCGGGCCTGCACCATGAGCGTCCCGGCCTTCATCGACATC
AGTGAAGAAGATCAGGCAGCTGAGTATGTCCCAGAGAAGGTGAAGAAAGCGGAAAAGAAATTAGAAGAGAATCCATATGACCTTGATGCT
TGGAGCATTCTCATTCGAGAGGCACAGAATCAACCTATAGACAAAGCACGGAAGACTTATGAACGCCTTGTTGCCCAGTTCCCCAGTTCT
GGCAGATTCTGGAAACTGTACATTGAAGCAGAGATTAAAGCTAAAAATTATGACAAGGTTGAAAAGCTATTTCAGAGATGCCTTATGAAG
GTTTTGCACATTGATTTATGGAAGTGTTATCTTTCATATGTCCGAGAAACCAAGGGTAAACTACCAAGTTACAAAGAAAAAATGGCTCAA
GCATATGACTTTGCACTGGATAAAATTGGAATGGAAATTATGTCCTATCAGATTTGGGTGGATTACATCAATTTCCTAAAAGGCGTGGAA
GCTGTAGGATCTTATGCAGAAAATCAAAGAATAACAGCTGTCCGAAGAGTTTATCAACGAGGTTGTGTTAATCCGATGATCAACATTGAA
CAGCTCTGGAGAGACTATAACAAGTATGAAGAGGGTATCAATATTCATTTAGCTAAAAAAATGATTGAAGATCGGAGTAGAGATTATATG
AATGCTAGACGTGTAGCAAAGGAATATGAGACAGTAATGAAAGGCTTGGACCGTAATGCTCCCTCGGTGCCTCCTCAGAATACTCCTCAA
GAAGCTCAACAAGTAGATATGTGGAAGAAATATATACAGTGGGAAAAGAGCAACCCTCTTCGTACAGAGGATCAGACCCTTATAACAAAA
AGAGTTATGTTTGCTTATGAACAGTGCCTGCTTGTGCTGGGCCATCACCCTGATATTTGGTATGAAGCTGCCCAGTATCTTGAGCAGTCA
AGTAAACTGCTCGCAGAAAAGGGAGATATGAATAATGCCAAATTATTTAGTGATGAAGCTGCTAATATATATGAAAGAGCCATAAGCACT
TTATTGAAGAAGAATATGCTTCTTTATTTTGCATATGCAGATTATGAAGAGAGTCGCATGAAGTATGAAAAGGTTCACAGTATATATAAC
AGACTTCTGGCAATTGAGGATATTGACCCTACCTTGGTATATATCCAATATATGAAATTTGCACGGAGAGCAGAAGGCATCAAATCTGGA
AGAATGATATTTAAAAAAGCAAGAGAAGATACCAGAACCCGCCACCATGTCTATGTTACTGCAGCACTCATGGAATATTACTGTAGTAAG
GACAAATCTGTTGCCTTTAAGATTTTTGAGCTGGGGCTAAAAAAATATGGAGACATTCCAGAGTATGTCCTGGCCTATATTGACTATCTT
TCTCACCTCAATGAGGACAATAATACCCGAGTTTTGTTTGAACGAGTTTTAACATCTGGAAGCCTTCCTCCTGAGAAGTCTGGAGAAATC
TGGGCCCGATTTCTAGCATTTGAAAGTAATATTGGTGATCTAGCTAGTATACTCAAAGTGGAGAAAAGACGGTTTACAGCATTCAAAGAA
GAGTATGAAGGGAAAGAAACGGCTTTACTAGTAGATAGATACAAGTTCATGGATTTATATCCTTGCTCTGCAAGTGAATTAAAAGCACTT
GGTTATAAGGATGTCTCCCGTGCTAAGCTAGCAGCTATAATTCCGGACCCAGTTGTAGCTCCTTCTATAGTGCCTGTTCTGAAAGATGAA
GTGGATAGAAAACCAGAATACCCTAAACCAGACACTCAGCAGATGATTCCATTTCAGCCACGACATTTAGCACCTCCAGGTTTACACCCT
GTACCTGGTGGAGTGTTCCCAGTCCCTCCTGCAGCTGTTGTTTTAATGAAACTTCTCCCTCCTCCTATCTGTTTCCAGGGTCCTTTTGTA
CAAGTGGATGAACTGATGGAAATTTTCCGAAGATGCAAGATACCAAATACTGTTGAGGAAGCTGTGAGGATCATTACTGGTGGGGCCCCA
GAGCTAGCTGTAGAAGGCAACGGCCCCGTGGAAAGTAATGCAGTACTCACCAAGGCCGTCAAAAGGCCCAACGAGGATTCAGATGAAGAT
GAAGAAAAGGGAGCCGTTGTCCCCCCTGTTCATGACATTTACAGAGCACGGCAGCAGAAGCGGATTCGGTAGGGTTTTAAACGCCTCTGC
AGAAAACTCCTGTCCAGGATTCCTTTTGCCTCAAGTGGTATGTTTAAAAGAGACAACGCTTTGTTACAAGGTTCTTGGAAACAAAGTTGT
ATTGTCATTGGTGCCTCTATCACATGGTTCTTGAGAAAAAACAAACCAACCTGTGTGAATTTTAGAATACGGAACAGACCTATGCTCTAA
GCAAAATTAGGTTTTCAAAAATGTGAGAACAGTACAAAGTGGCAGAACCACATTTTGTTCCCTCTTCAAGGGTGTCTTGTATGTGCCGCT
TGAAGATTTGTGAGTTTTTCAACAGTTTTATTTTAAAAACTGGATGGCTTATGATTGTAAAGCATTTTATCACATTTTCTGAAAACAATT
GTTCTTGGTTTGCTTATGTAGAGTCCTGCCTTATTGTTTGTTTTTATTTATGGCAGAATGTATGAAATCCGTTTTGTAGTTTCAAATTTT

>In-frame_ENST00000531120_ENST00000323959_TCGA-57-1993-01A_EIF3M_chr11_32605475_+_CSTF3_chr11_33163532_length(amino acids)=722AA_start in transcript=63_stop in transcript=2231
MSVPAFIDISEEDQAAEYVPEKVKKAEKKLEENPYDLDAWSILIREAQNQPIDKARKTYERLVAQFPSSGRFWKLYIEAEIKAKNYDKVE
KLFQRCLMKVLHIDLWKCYLSYVRETKGKLPSYKEKMAQAYDFALDKIGMEIMSYQIWVDYINFLKGVEAVGSYAENQRITAVRRVYQRG
CVNPMINIEQLWRDYNKYEEGINIHLAKKMIEDRSRDYMNARRVAKEYETVMKGLDRNAPSVPPQNTPQEAQQVDMWKKYIQWEKSNPLR
TEDQTLITKRVMFAYEQCLLVLGHHPDIWYEAAQYLEQSSKLLAEKGDMNNAKLFSDEAANIYERAISTLLKKNMLLYFAYADYEESRMK
YEKVHSIYNRLLAIEDIDPTLVYIQYMKFARRAEGIKSGRMIFKKAREDTRTRHHVYVTAALMEYYCSKDKSVAFKIFELGLKKYGDIPE
YVLAYIDYLSHLNEDNNTRVLFERVLTSGSLPPEKSGEIWARFLAFESNIGDLASILKVEKRRFTAFKEEYEGKETALLVDRYKFMDLYP
CSASELKALGYKDVSRAKLAAIIPDPVVAPSIVPVLKDEVDRKPEYPKPDTQQMIPFQPRHLAPPGLHPVPGGVFPVPPAAVVLMKLLPP
PICFQGPFVQVDELMEIFRRCKIPNTVEEAVRIITGGAPELAVEGNGPVESNAVLTKAVKRPNEDSDEDEEKGAVVPPVHDIYRARQQKR

--------------------------------------------------------------
>In-frame_ENST00000531120_ENST00000524827_TCGA-57-1993-01A_EIF3M_chr11_32605475_+_CSTF3_chr11_33163532_length(transcript)=540nt_BP=105nt
AGTTCCCTTTTCCGGTCGGCGTGGTCTTGCGAGTGGAGTGTCCGCTGTGCCCGGGCCTGCACCATGAGCGTCCCGGCCTTCATCGACATC
AGTGAAGAAGATCAGGCAGCTGAGTATGTCCCAGAGAAGGTGAAGAAAGCGGAAAAGAAATTAGAAGAGAATCCATATGACCTTGATGCT
TGGAGCATTCTCATTCGAGAGGCACAGAATCAACCTATAGACAAAGCACGGAAGACTTATGAACGCCTTGTTGCCCAGTTCCCCAGTTCT
GGCAGATTCTGGAAACTGTACATTGAAGCAGAGATTAAAGCTAAAAATTATGACAAGGTTGAAAAGCTATTTCAGAGATGCCTTATGAAG
GTTTTGCACATTGATTTATGGAAGTGTTATCTTTCATATGTCCGAGAAACCAAGGGTAAACTACCAAGTTACAAAGAAAAAATGGCTCAA
GCATATGACTTTGCACTGGATAAAATTGGAATGGAAATTATGTCCTATCAGATTTGGGTGGATTACATCAATTTCCTAAAAGGCGTGTAA

>In-frame_ENST00000531120_ENST00000524827_TCGA-57-1993-01A_EIF3M_chr11_32605475_+_CSTF3_chr11_33163532_length(amino acids)=158AA_start in transcript=63_stop in transcript=539
MSVPAFIDISEEDQAAEYVPEKVKKAEKKLEENPYDLDAWSILIREAQNQPIDKARKTYERLVAQFPSSGRFWKLYIEAEIKAKNYDKVE

--------------------------------------------------------------
>In-frame_ENST00000524896_ENST00000323959_TCGA-57-1993-01A_EIF3M_chr11_32605475_+_CSTF3_chr11_33163532_length(transcript)=2726nt_BP=96nt
TTCCGGTCGGCGTGGTCTTGCGAGTGGAGTGTCCGCTGTGCCCGGGCCTGCACCATGAGCGTCCCGGCCTTCATCGACATCAGTGAAGAA
GATCAGGCAGCTGAGTATGTCCCAGAGAAGGTGAAGAAAGCGGAAAAGAAATTAGAAGAGAATCCATATGACCTTGATGCTTGGAGCATT
CTCATTCGAGAGGCACAGAATCAACCTATAGACAAAGCACGGAAGACTTATGAACGCCTTGTTGCCCAGTTCCCCAGTTCTGGCAGATTC
TGGAAACTGTACATTGAAGCAGAGATTAAAGCTAAAAATTATGACAAGGTTGAAAAGCTATTTCAGAGATGCCTTATGAAGGTTTTGCAC
ATTGATTTATGGAAGTGTTATCTTTCATATGTCCGAGAAACCAAGGGTAAACTACCAAGTTACAAAGAAAAAATGGCTCAAGCATATGAC
TTTGCACTGGATAAAATTGGAATGGAAATTATGTCCTATCAGATTTGGGTGGATTACATCAATTTCCTAAAAGGCGTGGAAGCTGTAGGA
TCTTATGCAGAAAATCAAAGAATAACAGCTGTCCGAAGAGTTTATCAACGAGGTTGTGTTAATCCGATGATCAACATTGAACAGCTCTGG
AGAGACTATAACAAGTATGAAGAGGGTATCAATATTCATTTAGCTAAAAAAATGATTGAAGATCGGAGTAGAGATTATATGAATGCTAGA
CGTGTAGCAAAGGAATATGAGACAGTAATGAAAGGCTTGGACCGTAATGCTCCCTCGGTGCCTCCTCAGAATACTCCTCAAGAAGCTCAA
CAAGTAGATATGTGGAAGAAATATATACAGTGGGAAAAGAGCAACCCTCTTCGTACAGAGGATCAGACCCTTATAACAAAAAGAGTTATG
TTTGCTTATGAACAGTGCCTGCTTGTGCTGGGCCATCACCCTGATATTTGGTATGAAGCTGCCCAGTATCTTGAGCAGTCAAGTAAACTG
CTCGCAGAAAAGGGAGATATGAATAATGCCAAATTATTTAGTGATGAAGCTGCTAATATATATGAAAGAGCCATAAGCACTTTATTGAAG
AAGAATATGCTTCTTTATTTTGCATATGCAGATTATGAAGAGAGTCGCATGAAGTATGAAAAGGTTCACAGTATATATAACAGACTTCTG
GCAATTGAGGATATTGACCCTACCTTGGTATATATCCAATATATGAAATTTGCACGGAGAGCAGAAGGCATCAAATCTGGAAGAATGATA
TTTAAAAAAGCAAGAGAAGATACCAGAACCCGCCACCATGTCTATGTTACTGCAGCACTCATGGAATATTACTGTAGTAAGGACAAATCT
GTTGCCTTTAAGATTTTTGAGCTGGGGCTAAAAAAATATGGAGACATTCCAGAGTATGTCCTGGCCTATATTGACTATCTTTCTCACCTC
AATGAGGACAATAATACCCGAGTTTTGTTTGAACGAGTTTTAACATCTGGAAGCCTTCCTCCTGAGAAGTCTGGAGAAATCTGGGCCCGA
TTTCTAGCATTTGAAAGTAATATTGGTGATCTAGCTAGTATACTCAAAGTGGAGAAAAGACGGTTTACAGCATTCAAAGAAGAGTATGAA
GGGAAAGAAACGGCTTTACTAGTAGATAGATACAAGTTCATGGATTTATATCCTTGCTCTGCAAGTGAATTAAAAGCACTTGGTTATAAG
GATGTCTCCCGTGCTAAGCTAGCAGCTATAATTCCGGACCCAGTTGTAGCTCCTTCTATAGTGCCTGTTCTGAAAGATGAAGTGGATAGA
AAACCAGAATACCCTAAACCAGACACTCAGCAGATGATTCCATTTCAGCCACGACATTTAGCACCTCCAGGTTTACACCCTGTACCTGGT
GGAGTGTTCCCAGTCCCTCCTGCAGCTGTTGTTTTAATGAAACTTCTCCCTCCTCCTATCTGTTTCCAGGGTCCTTTTGTACAAGTGGAT
GAACTGATGGAAATTTTCCGAAGATGCAAGATACCAAATACTGTTGAGGAAGCTGTGAGGATCATTACTGGTGGGGCCCCAGAGCTAGCT
GTAGAAGGCAACGGCCCCGTGGAAAGTAATGCAGTACTCACCAAGGCCGTCAAAAGGCCCAACGAGGATTCAGATGAAGATGAAGAAAAG
GGAGCCGTTGTCCCCCCTGTTCATGACATTTACAGAGCACGGCAGCAGAAGCGGATTCGGTAGGGTTTTAAACGCCTCTGCAGAAAACTC
CTGTCCAGGATTCCTTTTGCCTCAAGTGGTATGTTTAAAAGAGACAACGCTTTGTTACAAGGTTCTTGGAAACAAAGTTGTATTGTCATT
GGTGCCTCTATCACATGGTTCTTGAGAAAAAACAAACCAACCTGTGTGAATTTTAGAATACGGAACAGACCTATGCTCTAAGCAAAATTA
GGTTTTCAAAAATGTGAGAACAGTACAAAGTGGCAGAACCACATTTTGTTCCCTCTTCAAGGGTGTCTTGTATGTGCCGCTTGAAGATTT
GTGAGTTTTTCAACAGTTTTATTTTAAAAACTGGATGGCTTATGATTGTAAAGCATTTTATCACATTTTCTGAAAACAATTGTTCTTGGT
TTGCTTATGTAGAGTCCTGCCTTATTGTTTGTTTTTATTTATGGCAGAATGTATGAAATCCGTTTTGTAGTTTCAAATTTTAAAAGTCCT

>In-frame_ENST00000524896_ENST00000323959_TCGA-57-1993-01A_EIF3M_chr11_32605475_+_CSTF3_chr11_33163532_length(amino acids)=722AA_start in transcript=54_stop in transcript=2222
MSVPAFIDISEEDQAAEYVPEKVKKAEKKLEENPYDLDAWSILIREAQNQPIDKARKTYERLVAQFPSSGRFWKLYIEAEIKAKNYDKVE
KLFQRCLMKVLHIDLWKCYLSYVRETKGKLPSYKEKMAQAYDFALDKIGMEIMSYQIWVDYINFLKGVEAVGSYAENQRITAVRRVYQRG
CVNPMINIEQLWRDYNKYEEGINIHLAKKMIEDRSRDYMNARRVAKEYETVMKGLDRNAPSVPPQNTPQEAQQVDMWKKYIQWEKSNPLR
TEDQTLITKRVMFAYEQCLLVLGHHPDIWYEAAQYLEQSSKLLAEKGDMNNAKLFSDEAANIYERAISTLLKKNMLLYFAYADYEESRMK
YEKVHSIYNRLLAIEDIDPTLVYIQYMKFARRAEGIKSGRMIFKKAREDTRTRHHVYVTAALMEYYCSKDKSVAFKIFELGLKKYGDIPE
YVLAYIDYLSHLNEDNNTRVLFERVLTSGSLPPEKSGEIWARFLAFESNIGDLASILKVEKRRFTAFKEEYEGKETALLVDRYKFMDLYP
CSASELKALGYKDVSRAKLAAIIPDPVVAPSIVPVLKDEVDRKPEYPKPDTQQMIPFQPRHLAPPGLHPVPGGVFPVPPAAVVLMKLLPP
PICFQGPFVQVDELMEIFRRCKIPNTVEEAVRIITGGAPELAVEGNGPVESNAVLTKAVKRPNEDSDEDEEKGAVVPPVHDIYRARQQKR

--------------------------------------------------------------
>In-frame_ENST00000524896_ENST00000524827_TCGA-57-1993-01A_EIF3M_chr11_32605475_+_CSTF3_chr11_33163532_length(transcript)=531nt_BP=96nt
TTCCGGTCGGCGTGGTCTTGCGAGTGGAGTGTCCGCTGTGCCCGGGCCTGCACCATGAGCGTCCCGGCCTTCATCGACATCAGTGAAGAA
GATCAGGCAGCTGAGTATGTCCCAGAGAAGGTGAAGAAAGCGGAAAAGAAATTAGAAGAGAATCCATATGACCTTGATGCTTGGAGCATT
CTCATTCGAGAGGCACAGAATCAACCTATAGACAAAGCACGGAAGACTTATGAACGCCTTGTTGCCCAGTTCCCCAGTTCTGGCAGATTC
TGGAAACTGTACATTGAAGCAGAGATTAAAGCTAAAAATTATGACAAGGTTGAAAAGCTATTTCAGAGATGCCTTATGAAGGTTTTGCAC
ATTGATTTATGGAAGTGTTATCTTTCATATGTCCGAGAAACCAAGGGTAAACTACCAAGTTACAAAGAAAAAATGGCTCAAGCATATGAC

>In-frame_ENST00000524896_ENST00000524827_TCGA-57-1993-01A_EIF3M_chr11_32605475_+_CSTF3_chr11_33163532_length(amino acids)=158AA_start in transcript=54_stop in transcript=530
MSVPAFIDISEEDQAAEYVPEKVKKAEKKLEENPYDLDAWSILIREAQNQPIDKARKTYERLVAQFPSSGRFWKLYIEAEIKAKNYDKVE

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Fusion Gene PPI Analysis for EIF3M-CSTF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneEIF3Mchr11:32605475chr11:33163532ENST00000531120+111344_37414.0375.0HSV-1 and HSV-2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EIF3M-CSTF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EIF3M-CSTF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource