FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:EIF4G2-EIF4G2 (FusionGDB2 ID:25995)

Fusion Gene Summary for EIF4G2-EIF4G2

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF4G2-EIF4G2
Fusion gene ID: 25995
HgeneTgene
Gene symbol

EIF4G2

EIF4G2

Gene ID

1982

1982

Gene nameeukaryotic translation initiation factor 4 gamma 2eukaryotic translation initiation factor 4 gamma 2
SynonymsAAG1|DAP5|NAT1|P97AAG1|DAP5|NAT1|P97
Cytomap

11p15.4

11p15.4

Type of geneprotein-codingprotein-coding
Descriptioneukaryotic translation initiation factor 4 gamma 2DAP-5aging-associated protein 1death-associated protein 5eIF-4-gamma 2eIF-4G 2eIF4G 2eukaryotic translation initiation factor 4G-like 1eukaryotic translation initiation factor 4 gamma 2DAP-5aging-associated protein 1death-associated protein 5eIF-4-gamma 2eIF-4G 2eIF4G 2eukaryotic translation initiation factor 4G-like 1
Modification date2020031320200313
UniProtAcc

P78344

P78344

Ensembl transtripts involved in fusion geneENST00000526148, ENST00000525681, 
ENST00000339995, ENST00000396525, 
ENST00000525995, 		ENST00000526148, 
ENST00000525681, ENST00000339995, 
ENST00000396525, ENST00000525995, 
Fusion gene scores* DoF score23 X 17 X 10=391026 X 29 X 7=5278
# samples 2831
** MAII scorelog2(28/3910*10)=-3.80366987524975
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(31/5278*10)=-4.08965123005203
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EIF4G2 [Title/Abstract] AND EIF4G2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEIF4G2(10823908)-EIF4G2(10825034), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEIF4G2

GO:0006446

regulation of translational initiation

11943866

TgeneEIF4G2

GO:0006446

regulation of translational initiation

11943866


check buttonFusion gene breakpoints across EIF4G2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across EIF4G2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAW367062EIF4G2chr11

10827587

+EIF4G2chr11

10822574

-
ChiTaRS5.0N/AAW837948EIF4G2chr11

10819304

+EIF4G2chr11

10818839

+
ChiTaRS5.0N/AAW948786EIF4G2chr11

10823908

-EIF4G2chr11

10825034

+
ChiTaRS5.0N/AAW948789EIF4G2chr11

10823908

-EIF4G2chr11

10825034

+
ChiTaRS5.0N/AAW999110EIF4G2chr11

10818873

-EIF4G2chr11

10818982

+
ChiTaRS5.0N/ABG822944EIF4G2chr11

10825598

+EIF4G2chr11

10825535

-
ChiTaRS5.0N/ABU187908EIF4G2chr11

10820972

+EIF4G2chr11

10820888

-


Top

Fusion Gene ORF analysis for EIF4G2-EIF4G2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000526148ENST00000526148EIF4G2chr11

10827587

+EIF4G2chr11

10822574

-
intron-3CDSENST00000526148ENST00000525681EIF4G2chr11

10827587

+EIF4G2chr11

10822574

-
intron-3CDSENST00000526148ENST00000339995EIF4G2chr11

10827587

+EIF4G2chr11

10822574

-
intron-3CDSENST00000526148ENST00000396525EIF4G2chr11

10827587

+EIF4G2chr11

10822574

-
intron-intronENST00000526148ENST00000525995EIF4G2chr11

10827587

+EIF4G2chr11

10822574

-
intron-3CDSENST00000525681ENST00000526148EIF4G2chr11

10827587

+EIF4G2chr11

10822574

-
intron-3CDSENST00000525681ENST00000525681EIF4G2chr11

10827587

+EIF4G2chr11

10822574

-
intron-3CDSENST00000525681ENST00000339995EIF4G2chr11

10827587

+EIF4G2chr11

10822574

-
intron-3CDSENST00000525681ENST00000396525EIF4G2chr11

10827587

+EIF4G2chr11

10822574

-
intron-intronENST00000525681ENST00000525995EIF4G2chr11

10827587

+EIF4G2chr11

10822574

-
intron-3CDSENST00000339995ENST00000526148EIF4G2chr11

10827587

+EIF4G2chr11

10822574

-
intron-3CDSENST00000339995ENST00000525681EIF4G2chr11

10827587

+EIF4G2chr11

10822574

-
intron-3CDSENST00000339995ENST00000339995EIF4G2chr11

10827587

+EIF4G2chr11

10822574

-
intron-3CDSENST00000339995ENST00000396525EIF4G2chr11

10827587

+EIF4G2chr11

10822574

-
intron-intronENST00000339995ENST00000525995EIF4G2chr11

10827587

+EIF4G2chr11

10822574

-
intron-3CDSENST00000396525ENST00000526148EIF4G2chr11

10827587

+EIF4G2chr11

10822574

-
intron-3CDSENST00000396525ENST00000525681EIF4G2chr11

10827587

+EIF4G2chr11

10822574

-
intron-3CDSENST00000396525ENST00000339995EIF4G2chr11

10827587

+EIF4G2chr11

10822574

-
intron-3CDSENST00000396525ENST00000396525EIF4G2chr11

10827587

+EIF4G2chr11

10822574

-
intron-intronENST00000396525ENST00000525995EIF4G2chr11

10827587

+EIF4G2chr11

10822574

-
intron-3CDSENST00000525995ENST00000526148EIF4G2chr11

10827587

+EIF4G2chr11

10822574

-
intron-3CDSENST00000525995ENST00000525681EIF4G2chr11

10827587

+EIF4G2chr11

10822574

-
intron-3CDSENST00000525995ENST00000339995EIF4G2chr11

10827587

+EIF4G2chr11

10822574

-
intron-3CDSENST00000525995ENST00000396525EIF4G2chr11

10827587

+EIF4G2chr11

10822574

-
intron-intronENST00000525995ENST00000525995EIF4G2chr11

10827587

+EIF4G2chr11

10822574

-
intron-3UTRENST00000526148ENST00000526148EIF4G2chr11

10819304

+EIF4G2chr11

10818839

+
intron-3UTRENST00000526148ENST00000525681EIF4G2chr11

10819304

+EIF4G2chr11

10818839

+
intron-3UTRENST00000526148ENST00000339995EIF4G2chr11

10819304

+EIF4G2chr11

10818839

+
intron-3UTRENST00000526148ENST00000396525EIF4G2chr11

10819304

+EIF4G2chr11

10818839

+
intron-intronENST00000526148ENST00000525995EIF4G2chr11

10819304

+EIF4G2chr11

10818839

+
intron-3UTRENST00000525681ENST00000526148EIF4G2chr11

10819304

+EIF4G2chr11

10818839

+
intron-3UTRENST00000525681ENST00000525681EIF4G2chr11

10819304

+EIF4G2chr11

10818839

+
intron-3UTRENST00000525681ENST00000339995EIF4G2chr11

10819304

+EIF4G2chr11

10818839

+
intron-3UTRENST00000525681ENST00000396525EIF4G2chr11

10819304

+EIF4G2chr11

10818839

+
intron-intronENST00000525681ENST00000525995EIF4G2chr11

10819304

+EIF4G2chr11

10818839

+
intron-3UTRENST00000339995ENST00000526148EIF4G2chr11

10819304

+EIF4G2chr11

10818839

+
intron-3UTRENST00000339995ENST00000525681EIF4G2chr11

10819304

+EIF4G2chr11

10818839

+
intron-3UTRENST00000339995ENST00000339995EIF4G2chr11

10819304

+EIF4G2chr11

10818839

+
intron-3UTRENST00000339995ENST00000396525EIF4G2chr11

10819304

+EIF4G2chr11

10818839

+
intron-intronENST00000339995ENST00000525995EIF4G2chr11

10819304

+EIF4G2chr11

10818839

+
intron-3UTRENST00000396525ENST00000526148EIF4G2chr11

10819304

+EIF4G2chr11

10818839

+
intron-3UTRENST00000396525ENST00000525681EIF4G2chr11

10819304

+EIF4G2chr11

10818839

+
intron-3UTRENST00000396525ENST00000339995EIF4G2chr11

10819304

+EIF4G2chr11

10818839

+
intron-3UTRENST00000396525ENST00000396525EIF4G2chr11

10819304

+EIF4G2chr11

10818839

+
intron-intronENST00000396525ENST00000525995EIF4G2chr11

10819304

+EIF4G2chr11

10818839

+
intron-3UTRENST00000525995ENST00000526148EIF4G2chr11

10819304

+EIF4G2chr11

10818839

+
intron-3UTRENST00000525995ENST00000525681EIF4G2chr11

10819304

+EIF4G2chr11

10818839

+
intron-3UTRENST00000525995ENST00000339995EIF4G2chr11

10819304

+EIF4G2chr11

10818839

+
intron-3UTRENST00000525995ENST00000396525EIF4G2chr11

10819304

+EIF4G2chr11

10818839

+
intron-intronENST00000525995ENST00000525995EIF4G2chr11

10819304

+EIF4G2chr11

10818839

+
intron-3CDSENST00000526148ENST00000526148EIF4G2chr11

10823908

-EIF4G2chr11

10825034

+
intron-3CDSENST00000526148ENST00000525681EIF4G2chr11

10823908

-EIF4G2chr11

10825034

+
intron-3CDSENST00000526148ENST00000339995EIF4G2chr11

10823908

-EIF4G2chr11

10825034

+
intron-3CDSENST00000526148ENST00000396525EIF4G2chr11

10823908

-EIF4G2chr11

10825034

+
intron-intronENST00000526148ENST00000525995EIF4G2chr11

10823908

-EIF4G2chr11

10825034

+
intron-3CDSENST00000525681ENST00000526148EIF4G2chr11

10823908

-EIF4G2chr11

10825034

+
intron-3CDSENST00000525681ENST00000525681EIF4G2chr11

10823908

-EIF4G2chr11

10825034

+
intron-3CDSENST00000525681ENST00000339995EIF4G2chr11

10823908

-EIF4G2chr11

10825034

+
intron-3CDSENST00000525681ENST00000396525EIF4G2chr11

10823908

-EIF4G2chr11

10825034

+
intron-intronENST00000525681ENST00000525995EIF4G2chr11

10823908

-EIF4G2chr11

10825034

+
intron-3CDSENST00000339995ENST00000526148EIF4G2chr11

10823908

-EIF4G2chr11

10825034

+
intron-3CDSENST00000339995ENST00000525681EIF4G2chr11

10823908

-EIF4G2chr11

10825034

+
intron-3CDSENST00000339995ENST00000339995EIF4G2chr11

10823908

-EIF4G2chr11

10825034

+
intron-3CDSENST00000339995ENST00000396525EIF4G2chr11

10823908

-EIF4G2chr11

10825034

+
intron-intronENST00000339995ENST00000525995EIF4G2chr11

10823908

-EIF4G2chr11

10825034

+
intron-3CDSENST00000396525ENST00000526148EIF4G2chr11

10823908

-EIF4G2chr11

10825034

+
intron-3CDSENST00000396525ENST00000525681EIF4G2chr11

10823908

-EIF4G2chr11

10825034

+
intron-3CDSENST00000396525ENST00000339995EIF4G2chr11

10823908

-EIF4G2chr11

10825034

+
intron-3CDSENST00000396525ENST00000396525EIF4G2chr11

10823908

-EIF4G2chr11

10825034

+
intron-intronENST00000396525ENST00000525995EIF4G2chr11

10823908

-EIF4G2chr11

10825034

+
intron-3CDSENST00000525995ENST00000526148EIF4G2chr11

10823908

-EIF4G2chr11

10825034

+
intron-3CDSENST00000525995ENST00000525681EIF4G2chr11

10823908

-EIF4G2chr11

10825034

+
intron-3CDSENST00000525995ENST00000339995EIF4G2chr11

10823908

-EIF4G2chr11

10825034

+
intron-3CDSENST00000525995ENST00000396525EIF4G2chr11

10823908

-EIF4G2chr11

10825034

+
intron-intronENST00000525995ENST00000525995EIF4G2chr11

10823908

-EIF4G2chr11

10825034

+
intron-3UTRENST00000526148ENST00000526148EIF4G2chr11

10818873

-EIF4G2chr11

10818982

+
intron-3UTRENST00000526148ENST00000525681EIF4G2chr11

10818873

-EIF4G2chr11

10818982

+
intron-3UTRENST00000526148ENST00000339995EIF4G2chr11

10818873

-EIF4G2chr11

10818982

+
intron-3UTRENST00000526148ENST00000396525EIF4G2chr11

10818873

-EIF4G2chr11

10818982

+
intron-intronENST00000526148ENST00000525995EIF4G2chr11

10818873

-EIF4G2chr11

10818982

+
intron-3UTRENST00000525681ENST00000526148EIF4G2chr11

10818873

-EIF4G2chr11

10818982

+
intron-3UTRENST00000525681ENST00000525681EIF4G2chr11

10818873

-EIF4G2chr11

10818982

+
intron-3UTRENST00000525681ENST00000339995EIF4G2chr11

10818873

-EIF4G2chr11

10818982

+
intron-3UTRENST00000525681ENST00000396525EIF4G2chr11

10818873

-EIF4G2chr11

10818982

+
intron-intronENST00000525681ENST00000525995EIF4G2chr11

10818873

-EIF4G2chr11

10818982

+
intron-3UTRENST00000339995ENST00000526148EIF4G2chr11

10818873

-EIF4G2chr11

10818982

+
intron-3UTRENST00000339995ENST00000525681EIF4G2chr11

10818873

-EIF4G2chr11

10818982

+
intron-3UTRENST00000339995ENST00000339995EIF4G2chr11

10818873

-EIF4G2chr11

10818982

+
intron-3UTRENST00000339995ENST00000396525EIF4G2chr11

10818873

-EIF4G2chr11

10818982

+
intron-intronENST00000339995ENST00000525995EIF4G2chr11

10818873

-EIF4G2chr11

10818982

+
intron-3UTRENST00000396525ENST00000526148EIF4G2chr11

10818873

-EIF4G2chr11

10818982

+
intron-3UTRENST00000396525ENST00000525681EIF4G2chr11

10818873

-EIF4G2chr11

10818982

+
intron-3UTRENST00000396525ENST00000339995EIF4G2chr11

10818873

-EIF4G2chr11

10818982

+
intron-3UTRENST00000396525ENST00000396525EIF4G2chr11

10818873

-EIF4G2chr11

10818982

+
intron-intronENST00000396525ENST00000525995EIF4G2chr11

10818873

-EIF4G2chr11

10818982

+
intron-3UTRENST00000525995ENST00000526148EIF4G2chr11

10818873

-EIF4G2chr11

10818982

+
intron-3UTRENST00000525995ENST00000525681EIF4G2chr11

10818873

-EIF4G2chr11

10818982

+
intron-3UTRENST00000525995ENST00000339995EIF4G2chr11

10818873

-EIF4G2chr11

10818982

+
intron-3UTRENST00000525995ENST00000396525EIF4G2chr11

10818873

-EIF4G2chr11

10818982

+
intron-intronENST00000525995ENST00000525995EIF4G2chr11

10818873

-EIF4G2chr11

10818982

+
intron-3CDSENST00000526148ENST00000526148EIF4G2chr11

10825598

+EIF4G2chr11

10825535

-
intron-3CDSENST00000526148ENST00000525681EIF4G2chr11

10825598

+EIF4G2chr11

10825535

-
intron-3CDSENST00000526148ENST00000339995EIF4G2chr11

10825598

+EIF4G2chr11

10825535

-
intron-3CDSENST00000526148ENST00000396525EIF4G2chr11

10825598

+EIF4G2chr11

10825535

-
intron-intronENST00000526148ENST00000525995EIF4G2chr11

10825598

+EIF4G2chr11

10825535

-
intron-3CDSENST00000525681ENST00000526148EIF4G2chr11

10825598

+EIF4G2chr11

10825535

-
intron-3CDSENST00000525681ENST00000525681EIF4G2chr11

10825598

+EIF4G2chr11

10825535

-
intron-3CDSENST00000525681ENST00000339995EIF4G2chr11

10825598

+EIF4G2chr11

10825535

-
intron-3CDSENST00000525681ENST00000396525EIF4G2chr11

10825598

+EIF4G2chr11

10825535

-
intron-intronENST00000525681ENST00000525995EIF4G2chr11

10825598

+EIF4G2chr11

10825535

-
intron-3CDSENST00000339995ENST00000526148EIF4G2chr11

10825598

+EIF4G2chr11

10825535

-
intron-3CDSENST00000339995ENST00000525681EIF4G2chr11

10825598

+EIF4G2chr11

10825535

-
intron-3CDSENST00000339995ENST00000339995EIF4G2chr11

10825598

+EIF4G2chr11

10825535

-
intron-3CDSENST00000339995ENST00000396525EIF4G2chr11

10825598

+EIF4G2chr11

10825535

-
intron-intronENST00000339995ENST00000525995EIF4G2chr11

10825598

+EIF4G2chr11

10825535

-
intron-3CDSENST00000396525ENST00000526148EIF4G2chr11

10825598

+EIF4G2chr11

10825535

-
intron-3CDSENST00000396525ENST00000525681EIF4G2chr11

10825598

+EIF4G2chr11

10825535

-
intron-3CDSENST00000396525ENST00000339995EIF4G2chr11

10825598

+EIF4G2chr11

10825535

-
intron-3CDSENST00000396525ENST00000396525EIF4G2chr11

10825598

+EIF4G2chr11

10825535

-
intron-intronENST00000396525ENST00000525995EIF4G2chr11

10825598

+EIF4G2chr11

10825535

-
intron-3CDSENST00000525995ENST00000526148EIF4G2chr11

10825598

+EIF4G2chr11

10825535

-
intron-3CDSENST00000525995ENST00000525681EIF4G2chr11

10825598

+EIF4G2chr11

10825535

-
intron-3CDSENST00000525995ENST00000339995EIF4G2chr11

10825598

+EIF4G2chr11

10825535

-
intron-3CDSENST00000525995ENST00000396525EIF4G2chr11

10825598

+EIF4G2chr11

10825535

-
intron-intronENST00000525995ENST00000525995EIF4G2chr11

10825598

+EIF4G2chr11

10825535

-
intron-3CDSENST00000526148ENST00000526148EIF4G2chr11

10820972

+EIF4G2chr11

10820888

-
intron-3CDSENST00000526148ENST00000525681EIF4G2chr11

10820972

+EIF4G2chr11

10820888

-
intron-3CDSENST00000526148ENST00000339995EIF4G2chr11

10820972

+EIF4G2chr11

10820888

-
intron-3CDSENST00000526148ENST00000396525EIF4G2chr11

10820972

+EIF4G2chr11

10820888

-
intron-intronENST00000526148ENST00000525995EIF4G2chr11

10820972

+EIF4G2chr11

10820888

-
intron-3CDSENST00000525681ENST00000526148EIF4G2chr11

10820972

+EIF4G2chr11

10820888

-
intron-3CDSENST00000525681ENST00000525681EIF4G2chr11

10820972

+EIF4G2chr11

10820888

-
intron-3CDSENST00000525681ENST00000339995EIF4G2chr11

10820972

+EIF4G2chr11

10820888

-
intron-3CDSENST00000525681ENST00000396525EIF4G2chr11

10820972

+EIF4G2chr11

10820888

-
intron-intronENST00000525681ENST00000525995EIF4G2chr11

10820972

+EIF4G2chr11

10820888

-
intron-3CDSENST00000339995ENST00000526148EIF4G2chr11

10820972

+EIF4G2chr11

10820888

-
intron-3CDSENST00000339995ENST00000525681EIF4G2chr11

10820972

+EIF4G2chr11

10820888

-
intron-3CDSENST00000339995ENST00000339995EIF4G2chr11

10820972

+EIF4G2chr11

10820888

-
intron-3CDSENST00000339995ENST00000396525EIF4G2chr11

10820972

+EIF4G2chr11

10820888

-
intron-intronENST00000339995ENST00000525995EIF4G2chr11

10820972

+EIF4G2chr11

10820888

-
intron-3CDSENST00000396525ENST00000526148EIF4G2chr11

10820972

+EIF4G2chr11

10820888

-
intron-3CDSENST00000396525ENST00000525681EIF4G2chr11

10820972

+EIF4G2chr11

10820888

-
intron-3CDSENST00000396525ENST00000339995EIF4G2chr11

10820972

+EIF4G2chr11

10820888

-
intron-3CDSENST00000396525ENST00000396525EIF4G2chr11

10820972

+EIF4G2chr11

10820888

-
intron-intronENST00000396525ENST00000525995EIF4G2chr11

10820972

+EIF4G2chr11

10820888

-
intron-3CDSENST00000525995ENST00000526148EIF4G2chr11

10820972

+EIF4G2chr11

10820888

-
intron-3CDSENST00000525995ENST00000525681EIF4G2chr11

10820972

+EIF4G2chr11

10820888

-
intron-3CDSENST00000525995ENST00000339995EIF4G2chr11

10820972

+EIF4G2chr11

10820888

-
intron-3CDSENST00000525995ENST00000396525EIF4G2chr11

10820972

+EIF4G2chr11

10820888

-
intron-intronENST00000525995ENST00000525995EIF4G2chr11

10820972

+EIF4G2chr11

10820888

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for EIF4G2-EIF4G2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for EIF4G2-EIF4G2


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EIF4G2

P78344

EIF4G2

P78344

FUNCTION: Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. {ECO:0000269|PubMed:11511540, ECO:0000269|PubMed:11943866, ECO:0000269|PubMed:9032289, ECO:0000269|PubMed:9049310}.FUNCTION: Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. {ECO:0000269|PubMed:11511540, ECO:0000269|PubMed:11943866, ECO:0000269|PubMed:9032289, ECO:0000269|PubMed:9049310}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for EIF4G2-EIF4G2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for EIF4G2-EIF4G2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for EIF4G2-EIF4G2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for EIF4G2-EIF4G2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource