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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EMC4-PARK7 (FusionGDB2 ID:26352)

Fusion Gene Summary for EMC4-PARK7

check button Fusion gene summary
Fusion gene informationFusion gene name: EMC4-PARK7
Fusion gene ID: 26352
HgeneTgene
Gene symbol

EMC4

PARK7

Gene ID

51234

11315

Gene nameER membrane protein complex subunit 4Parkinsonism associated deglycase
SynonymsPIG17|TMEM85DJ-1|DJ1|GATD2|HEL-S-67p
Cytomap

15q14

1p36.23

Type of geneprotein-codingprotein-coding
DescriptionER membrane protein complex subunit 4cell proliferation-inducing gene 17 proteintransmembrane protein 85protein/nucleic acid deglycase DJ-1Parkinson disease (autosomal recessive, early onset) 7epididymis secretory sperm binding protein Li 67pmaillard deglycaseoncogene DJ1parkinson protein 7protein DJ-1protein deglycase DJ-1
Modification date2020031320200327
UniProtAcc

Q5J8M3

.
Ensembl transtripts involved in fusion geneENST00000267750, ENST00000249209, 
ENST00000559078, ENST00000557879, 
ENST00000559421, 		ENST00000338639, 
ENST00000493678, ENST00000377493, 
ENST00000377491, ENST00000377488, 
ENST00000497113, 
Fusion gene scores* DoF score2 X 1 X 1=27 X 6 X 4=168
# samples 27
** MAII scorelog2(2/2*10)=3.32192809488736log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EMC4 [Title/Abstract] AND PARK7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEMC4(34520047)-PARK7(8037712), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePARK7

GO:0006281

DNA repair

28596309

TgenePARK7

GO:0006517

protein deglycosylation

25416785

TgenePARK7

GO:0006517

protein deglycosylation

27903648

TgenePARK7

GO:0009438

methylglyoxal metabolic process

22523093

TgenePARK7

GO:0009438

methylglyoxal metabolic process

27903648

TgenePARK7

GO:0010629

negative regulation of gene expression

22683601

TgenePARK7

GO:0019249

lactate biosynthetic process

22523093

TgenePARK7

GO:0031334

positive regulation of protein complex assembly

24947010

TgenePARK7

GO:0031397

negative regulation of protein ubiquitination

17015834|24899725

TgenePARK7

GO:0032091

negative regulation of protein binding

11477070|16731528|17015834|24899725

TgenePARK7

GO:0032435

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

17015834

TgenePARK7

GO:0032757

positive regulation of interleukin-8 production

21097510

TgenePARK7

GO:0033234

negative regulation of protein sumoylation

16731528

TgenePARK7

GO:0034599

cellular response to oxidative stress

15983381|19703902|20969476|22683601

TgenePARK7

GO:0036471

cellular response to glyoxal

22523093

TgenePARK7

GO:0036526

peptidyl-cysteine deglycation

25416785

TgenePARK7

GO:0036527

peptidyl-arginine deglycation

25416785

TgenePARK7

GO:0036528

peptidyl-lysine deglycation

25416785

TgenePARK7

GO:0036529

protein deglycation, glyoxal removal

25416785

TgenePARK7

GO:0036530

protein deglycation, methylglyoxal removal

25416785

TgenePARK7

GO:0036530

protein deglycation, methylglyoxal removal

27903648

TgenePARK7

GO:0036531

glutathione deglycation

25416785

TgenePARK7

GO:0042743

hydrogen peroxide metabolic process

20969476|24567322

TgenePARK7

GO:0043066

negative regulation of apoptotic process

22523093

TgenePARK7

GO:0043523

regulation of neuron apoptotic process

18711745|20304780

TgenePARK7

GO:0043524

negative regulation of neuron apoptotic process

22511790

TgenePARK7

GO:0045944

positive regulation of transcription by RNA polymerase II

21097510

TgenePARK7

GO:0046295

glycolate biosynthetic process

22523093

TgenePARK7

GO:0050821

protein stabilization

24947010

TgenePARK7

GO:0051444

negative regulation of ubiquitin-protein transferase activity

24899725

TgenePARK7

GO:0060548

negative regulation of cell death

14749723

TgenePARK7

GO:0060765

regulation of androgen receptor signaling pathway

11477070

TgenePARK7

GO:0070301

cellular response to hydrogen peroxide

14749723

TgenePARK7

GO:0106044

guanine deglycation

28596309

TgenePARK7

GO:0106045

guanine deglycation, methylglyoxal removal

28596309

TgenePARK7

GO:0106046

guanine deglycation, glyoxal removal

28596309

TgenePARK7

GO:1900182

positive regulation of protein localization to nucleus

21097510

TgenePARK7

GO:1901215

negative regulation of neuron death

22683601

TgenePARK7

GO:1901671

positive regulation of superoxide dismutase activity

24567322

TgenePARK7

GO:1901984

negative regulation of protein acetylation

22683601

TgenePARK7

GO:1903094

negative regulation of protein K48-linked deubiquitination

21097510

TgenePARK7

GO:1903168

positive regulation of pyrroline-5-carboxylate reductase activity

23743200

TgenePARK7

GO:1903178

positive regulation of tyrosine 3-monooxygenase activity

19703902

TgenePARK7

GO:1903181

positive regulation of dopamine biosynthetic process

19703902

TgenePARK7

GO:1903189

glyoxal metabolic process

22523093

TgenePARK7

GO:1903200

positive regulation of L-dopa decarboxylase activity

19703902

TgenePARK7

GO:1903202

negative regulation of oxidative stress-induced cell death

16632486

TgenePARK7

GO:1903208

negative regulation of hydrogen peroxide-induced neuron death

15983381|24947010

TgenePARK7

GO:1903377

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

15790595

TgenePARK7

GO:1905259

negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway

14752510

TgenePARK7

GO:2000157

negative regulation of ubiquitin-specific protease activity

21097510


check buttonFusion gene breakpoints across EMC4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PARK7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GN-01AEMC4chr15

34520047

+PARK7chr1

8037712

+


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Fusion Gene ORF analysis for EMC4-PARK7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000267750ENST00000338639EMC4chr15

34520047

+PARK7chr1

8037712

+
In-frameENST00000267750ENST00000493678EMC4chr15

34520047

+PARK7chr1

8037712

+
In-frameENST00000267750ENST00000377493EMC4chr15

34520047

+PARK7chr1

8037712

+
In-frameENST00000267750ENST00000377491EMC4chr15

34520047

+PARK7chr1

8037712

+
In-frameENST00000267750ENST00000377488EMC4chr15

34520047

+PARK7chr1

8037712

+
5CDS-intronENST00000267750ENST00000497113EMC4chr15

34520047

+PARK7chr1

8037712

+
In-frameENST00000249209ENST00000338639EMC4chr15

34520047

+PARK7chr1

8037712

+
In-frameENST00000249209ENST00000493678EMC4chr15

34520047

+PARK7chr1

8037712

+
In-frameENST00000249209ENST00000377493EMC4chr15

34520047

+PARK7chr1

8037712

+
In-frameENST00000249209ENST00000377491EMC4chr15

34520047

+PARK7chr1

8037712

+
In-frameENST00000249209ENST00000377488EMC4chr15

34520047

+PARK7chr1

8037712

+
5CDS-intronENST00000249209ENST00000497113EMC4chr15

34520047

+PARK7chr1

8037712

+
intron-3CDSENST00000559078ENST00000338639EMC4chr15

34520047

+PARK7chr1

8037712

+
intron-3CDSENST00000559078ENST00000493678EMC4chr15

34520047

+PARK7chr1

8037712

+
intron-3CDSENST00000559078ENST00000377493EMC4chr15

34520047

+PARK7chr1

8037712

+
intron-3CDSENST00000559078ENST00000377491EMC4chr15

34520047

+PARK7chr1

8037712

+
intron-3CDSENST00000559078ENST00000377488EMC4chr15

34520047

+PARK7chr1

8037712

+
intron-intronENST00000559078ENST00000497113EMC4chr15

34520047

+PARK7chr1

8037712

+
intron-3CDSENST00000557879ENST00000338639EMC4chr15

34520047

+PARK7chr1

8037712

+
intron-3CDSENST00000557879ENST00000493678EMC4chr15

34520047

+PARK7chr1

8037712

+
intron-3CDSENST00000557879ENST00000377493EMC4chr15

34520047

+PARK7chr1

8037712

+
intron-3CDSENST00000557879ENST00000377491EMC4chr15

34520047

+PARK7chr1

8037712

+
intron-3CDSENST00000557879ENST00000377488EMC4chr15

34520047

+PARK7chr1

8037712

+
intron-intronENST00000557879ENST00000497113EMC4chr15

34520047

+PARK7chr1

8037712

+
intron-3CDSENST00000559421ENST00000338639EMC4chr15

34520047

+PARK7chr1

8037712

+
intron-3CDSENST00000559421ENST00000493678EMC4chr15

34520047

+PARK7chr1

8037712

+
intron-3CDSENST00000559421ENST00000377493EMC4chr15

34520047

+PARK7chr1

8037712

+
intron-3CDSENST00000559421ENST00000377491EMC4chr15

34520047

+PARK7chr1

8037712

+
intron-3CDSENST00000559421ENST00000377488EMC4chr15

34520047

+PARK7chr1

8037712

+
intron-intronENST00000559421ENST00000497113EMC4chr15

34520047

+PARK7chr1

8037712

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000267750EMC4chr1534520047+ENST00000338639PARK7chr18037712+944471116718200
ENST00000267750EMC4chr1534520047+ENST00000493678PARK7chr18037712+1170471116718200
ENST00000267750EMC4chr1534520047+ENST00000377493PARK7chr18037712+946471116718200
ENST00000267750EMC4chr1534520047+ENST00000377491PARK7chr18037712+915471116718200
ENST00000267750EMC4chr1534520047+ENST00000377488PARK7chr18037712+776471116718200
ENST00000249209EMC4chr1534520047+ENST00000338639PARK7chr18037712+930457102704200
ENST00000249209EMC4chr1534520047+ENST00000493678PARK7chr18037712+1156457102704200
ENST00000249209EMC4chr1534520047+ENST00000377493PARK7chr18037712+932457102704200
ENST00000249209EMC4chr1534520047+ENST00000377491PARK7chr18037712+901457102704200
ENST00000249209EMC4chr1534520047+ENST00000377488PARK7chr18037712+762457102704200

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000267750ENST00000338639EMC4chr1534520047+PARK7chr18037712+0.0065765530.99342346
ENST00000267750ENST00000493678EMC4chr1534520047+PARK7chr18037712+0.0047737570.99522626
ENST00000267750ENST00000377493EMC4chr1534520047+PARK7chr18037712+0.0065962240.99340373
ENST00000267750ENST00000377491EMC4chr1534520047+PARK7chr18037712+0.0066481630.9933518
ENST00000267750ENST00000377488EMC4chr1534520047+PARK7chr18037712+0.0094313580.9905687
ENST00000249209ENST00000338639EMC4chr1534520047+PARK7chr18037712+0.0076065110.9923935
ENST00000249209ENST00000493678EMC4chr1534520047+PARK7chr18037712+0.0054410650.9945589
ENST00000249209ENST00000377493EMC4chr1534520047+PARK7chr18037712+0.0077458920.99225414
ENST00000249209ENST00000377491EMC4chr1534520047+PARK7chr18037712+0.0074512610.9925487
ENST00000249209ENST00000377488EMC4chr1534520047+PARK7chr18037712+0.0108313140.98916864

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Fusion Genomic Features for EMC4-PARK7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
EMC4chr1534520047+PARK7chr18037711+0.0008159040.9991841
EMC4chr1534520047+PARK7chr18037711+0.0008159040.9991841

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EMC4-PARK7


check button Go to

FGviewer for the breakpoints of chr15:34520047-chr1:8037712

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EMC4

Q5J8M3

.
FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176, PubMed:32439656). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). {ECO:0000269|PubMed:29242231, ECO:0000269|PubMed:29809151, ECO:0000269|PubMed:30415835, ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176, ECO:0000305|PubMed:18586032}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEMC4chr15:34520047chr1:8037712ENST00000249209+342_66118.33333333333333150.0Topological domainCytoplasmic
HgeneEMC4chr15:34520047chr1:8037712ENST00000249209+3488_98118.33333333333333150.0Topological domainLumenal
HgeneEMC4chr15:34520047chr1:8037712ENST00000267750+352_66118.33333333333333184.0Topological domainCytoplasmic
HgeneEMC4chr15:34520047chr1:8037712ENST00000267750+3588_98118.33333333333333184.0Topological domainLumenal
HgeneEMC4chr15:34520047chr1:8037712ENST00000249209+3467_87118.33333333333333150.0TransmembraneHelical
HgeneEMC4chr15:34520047chr1:8037712ENST00000249209+3499_120118.33333333333333150.0TransmembraneHelical
HgeneEMC4chr15:34520047chr1:8037712ENST00000267750+3567_87118.33333333333333184.0TransmembraneHelical
HgeneEMC4chr15:34520047chr1:8037712ENST00000267750+3599_120118.33333333333333184.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEMC4chr15:34520047chr1:8037712ENST00000249209+34121_127118.33333333333333150.0Topological domainCytoplasmic
HgeneEMC4chr15:34520047chr1:8037712ENST00000249209+34149_183118.33333333333333150.0Topological domainLumenal
HgeneEMC4chr15:34520047chr1:8037712ENST00000267750+35121_127118.33333333333333184.0Topological domainCytoplasmic
HgeneEMC4chr15:34520047chr1:8037712ENST00000267750+35149_183118.33333333333333184.0Topological domainLumenal
HgeneEMC4chr15:34520047chr1:8037712ENST00000249209+34128_148118.33333333333333150.0TransmembraneHelical
HgeneEMC4chr15:34520047chr1:8037712ENST00000267750+35128_148118.33333333333333184.0TransmembraneHelical


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Fusion Gene Sequence for EMC4-PARK7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000267750_ENST00000338639_TCGA-HU-A4GN-01A_EMC4_chr15_34520047_+_PARK7_chr1_8037712_length(transcript)=944nt_BP=471nt
ATTCACGCGCCGGAAGTGCATTTGCAGAGTGAGACAAAGCGGAGAACGCTGGTGGGCCTGTTGTGGAGTACGCTTTGGACTGAGAAGCAT
CGAGGCTATAGGACGCAGCTGTTGCCATGACGGCCCAGGGGGGCCTGGTGGCTAACCGAGGCCGGCGCTTCAAGTGGGCCATTGAGCTAA
GCGGGCCTGGAGGAGGCAGCAGGGGTCGAAGTGACCGGGGCAGTGGCCAGGGAGACTCGCTCTACCCAGTCGGTTACTTGGACAAGCAAG
TGCCTGATACCAGCGTGCAAGAGACAGACCGGATCCTGGTGGAGAAGCGCTGCTGGGACATCGCCTTGGGTCCCCTCAAACAGATTCCCA
TGAATCTCTTCATCATGTACATGGCAGGCAATACTATCTCCATCTTCCCTACTATGATGGTGTGTATGATGGCCTGGCGACCCATTCAGG
CACTTATGGCCATTTCAGCCAGTCCTACTGCTCTGTTGGCTCATGAAATAGGTTTTGGAAGTAAAGTTACAACACACCCTCTTGCTAAAG
ACAAAATGATGAATGGAGGTCATTACACCTACTCTGAGAATCGTGTGGAAAAAGACGGCCTGATTCTTACAAGCCGGGGGCCTGGGACCA
GCTTCGAGTTTGCGCTTGCAATTGTTGAAGCCCTGAATGGCAAGGAGGTGGCGGCTCAAGTGAAGGCTCCACTTGTTCTTAAAGACTAGA
GCAGCGAACTGCGACGATCACTTAGAGAAACAGGCCGTTAGGAATCCATTCTCACTGTGTTCGCTCTAAACAAAACAGTGGTAGGTTAAT
GTGTTCAGAAGTCGCTGTCCTTACTACTTTTGCGGAAGTATGGAAGTCACAACTACACAGAGATTTCTCAGCCTACAAATTGTGTCTATA

>In-frame_ENST00000267750_ENST00000338639_TCGA-HU-A4GN-01A_EMC4_chr15_34520047_+_PARK7_chr1_8037712_length(amino acids)=200AA_start in transcript=116_stop in transcript=718
MTAQGGLVANRGRRFKWAIELSGPGGGSRGRSDRGSGQGDSLYPVGYLDKQVPDTSVQETDRILVEKRCWDIALGPLKQIPMNLFIMYMA
GNTISIFPTMMVCMMAWRPIQALMAISASPTALLAHEIGFGSKVTTHPLAKDKMMNGGHYTYSENRVEKDGLILTSRGPGTSFEFALAIV

--------------------------------------------------------------
>In-frame_ENST00000267750_ENST00000493678_TCGA-HU-A4GN-01A_EMC4_chr15_34520047_+_PARK7_chr1_8037712_length(transcript)=1170nt_BP=471nt
ATTCACGCGCCGGAAGTGCATTTGCAGAGTGAGACAAAGCGGAGAACGCTGGTGGGCCTGTTGTGGAGTACGCTTTGGACTGAGAAGCAT
CGAGGCTATAGGACGCAGCTGTTGCCATGACGGCCCAGGGGGGCCTGGTGGCTAACCGAGGCCGGCGCTTCAAGTGGGCCATTGAGCTAA
GCGGGCCTGGAGGAGGCAGCAGGGGTCGAAGTGACCGGGGCAGTGGCCAGGGAGACTCGCTCTACCCAGTCGGTTACTTGGACAAGCAAG
TGCCTGATACCAGCGTGCAAGAGACAGACCGGATCCTGGTGGAGAAGCGCTGCTGGGACATCGCCTTGGGTCCCCTCAAACAGATTCCCA
TGAATCTCTTCATCATGTACATGGCAGGCAATACTATCTCCATCTTCCCTACTATGATGGTGTGTATGATGGCCTGGCGACCCATTCAGG
CACTTATGGCCATTTCAGCCAGTCCTACTGCTCTGTTGGCTCATGAAATAGGTTTTGGAAGTAAAGTTACAACACACCCTCTTGCTAAAG
ACAAAATGATGAATGGAGGTCATTACACCTACTCTGAGAATCGTGTGGAAAAAGACGGCCTGATTCTTACAAGCCGGGGGCCTGGGACCA
GCTTCGAGTTTGCGCTTGCAATTGTTGAAGCCCTGAATGGCAAGGAGGTGGCGGCTCAAGTGAAGGCTCCACTTGTTCTTAAAGACTAGA
GCAGCGAACTGCGACGATCACTTAGAGAAACAGGCCGTTAGGAATCCATTCTCACTGTGTTCGCTCTAAACAAAACAGTGGTAGGTTAAT
GTGTTCAGAAGTCGCTGTCCTTACTACTTTTGCGGAAGTATGGAAGTCACAACTACACAGAGATTTCTCAGCCTACAAATTGTGTCTATA
CATTTCTAAGCCTTGTTTGCAGAATAAACAGGGCATTTAGCAAACTACTGATTGTTTCTTGTTTTGTCTCTCATTTCTTTTGTGAAATTA
AATTCCGTATCACCTTCATTTGCAGCTCTTAACTGTCCATATGGCACTGAAATAAAAGAACAGTGACCACATTTTACACAGCAAGGAGGA
AAGGCATACAAACAGAATTTAAGAGGCTTGTGATTTTCTCTGCTTATTAGCTGTGTGTTTTTAATGTGCTATTAAAAAATACCAATGAGG

>In-frame_ENST00000267750_ENST00000493678_TCGA-HU-A4GN-01A_EMC4_chr15_34520047_+_PARK7_chr1_8037712_length(amino acids)=200AA_start in transcript=116_stop in transcript=718
MTAQGGLVANRGRRFKWAIELSGPGGGSRGRSDRGSGQGDSLYPVGYLDKQVPDTSVQETDRILVEKRCWDIALGPLKQIPMNLFIMYMA
GNTISIFPTMMVCMMAWRPIQALMAISASPTALLAHEIGFGSKVTTHPLAKDKMMNGGHYTYSENRVEKDGLILTSRGPGTSFEFALAIV

--------------------------------------------------------------
>In-frame_ENST00000267750_ENST00000377493_TCGA-HU-A4GN-01A_EMC4_chr15_34520047_+_PARK7_chr1_8037712_length(transcript)=946nt_BP=471nt
ATTCACGCGCCGGAAGTGCATTTGCAGAGTGAGACAAAGCGGAGAACGCTGGTGGGCCTGTTGTGGAGTACGCTTTGGACTGAGAAGCAT
CGAGGCTATAGGACGCAGCTGTTGCCATGACGGCCCAGGGGGGCCTGGTGGCTAACCGAGGCCGGCGCTTCAAGTGGGCCATTGAGCTAA
GCGGGCCTGGAGGAGGCAGCAGGGGTCGAAGTGACCGGGGCAGTGGCCAGGGAGACTCGCTCTACCCAGTCGGTTACTTGGACAAGCAAG
TGCCTGATACCAGCGTGCAAGAGACAGACCGGATCCTGGTGGAGAAGCGCTGCTGGGACATCGCCTTGGGTCCCCTCAAACAGATTCCCA
TGAATCTCTTCATCATGTACATGGCAGGCAATACTATCTCCATCTTCCCTACTATGATGGTGTGTATGATGGCCTGGCGACCCATTCAGG
CACTTATGGCCATTTCAGCCAGTCCTACTGCTCTGTTGGCTCATGAAATAGGTTTTGGAAGTAAAGTTACAACACACCCTCTTGCTAAAG
ACAAAATGATGAATGGAGGTCATTACACCTACTCTGAGAATCGTGTGGAAAAAGACGGCCTGATTCTTACAAGCCGGGGGCCTGGGACCA
GCTTCGAGTTTGCGCTTGCAATTGTTGAAGCCCTGAATGGCAAGGAGGTGGCGGCTCAAGTGAAGGCTCCACTTGTTCTTAAAGACTAGA
GCAGCGAACTGCGACGATCACTTAGAGAAACAGGCCGTTAGGAATCCATTCTCACTGTGTTCGCTCTAAACAAAACAGTGGTAGGTTAAT
GTGTTCAGAAGTCGCTGTCCTTACTACTTTTGCGGAAGTATGGAAGTCACAACTACACAGAGATTTCTCAGCCTACAAATTGTGTCTATA

>In-frame_ENST00000267750_ENST00000377493_TCGA-HU-A4GN-01A_EMC4_chr15_34520047_+_PARK7_chr1_8037712_length(amino acids)=200AA_start in transcript=116_stop in transcript=718
MTAQGGLVANRGRRFKWAIELSGPGGGSRGRSDRGSGQGDSLYPVGYLDKQVPDTSVQETDRILVEKRCWDIALGPLKQIPMNLFIMYMA
GNTISIFPTMMVCMMAWRPIQALMAISASPTALLAHEIGFGSKVTTHPLAKDKMMNGGHYTYSENRVEKDGLILTSRGPGTSFEFALAIV

--------------------------------------------------------------
>In-frame_ENST00000267750_ENST00000377491_TCGA-HU-A4GN-01A_EMC4_chr15_34520047_+_PARK7_chr1_8037712_length(transcript)=915nt_BP=471nt
ATTCACGCGCCGGAAGTGCATTTGCAGAGTGAGACAAAGCGGAGAACGCTGGTGGGCCTGTTGTGGAGTACGCTTTGGACTGAGAAGCAT
CGAGGCTATAGGACGCAGCTGTTGCCATGACGGCCCAGGGGGGCCTGGTGGCTAACCGAGGCCGGCGCTTCAAGTGGGCCATTGAGCTAA
GCGGGCCTGGAGGAGGCAGCAGGGGTCGAAGTGACCGGGGCAGTGGCCAGGGAGACTCGCTCTACCCAGTCGGTTACTTGGACAAGCAAG
TGCCTGATACCAGCGTGCAAGAGACAGACCGGATCCTGGTGGAGAAGCGCTGCTGGGACATCGCCTTGGGTCCCCTCAAACAGATTCCCA
TGAATCTCTTCATCATGTACATGGCAGGCAATACTATCTCCATCTTCCCTACTATGATGGTGTGTATGATGGCCTGGCGACCCATTCAGG
CACTTATGGCCATTTCAGCCAGTCCTACTGCTCTGTTGGCTCATGAAATAGGTTTTGGAAGTAAAGTTACAACACACCCTCTTGCTAAAG
ACAAAATGATGAATGGAGGTCATTACACCTACTCTGAGAATCGTGTGGAAAAAGACGGCCTGATTCTTACAAGCCGGGGGCCTGGGACCA
GCTTCGAGTTTGCGCTTGCAATTGTTGAAGCCCTGAATGGCAAGGAGGTGGCGGCTCAAGTGAAGGCTCCACTTGTTCTTAAAGACTAGA
GCAGCGAACTGCGACGATCACTTAGAGAAACAGGCCGTTAGGAATCCATTCTCACTGTGTTCGCTCTAAACAAAACAGTGGTAGGTTAAT
GTGTTCAGAAGTCGCTGTCCTTACTACTTTTGCGGAAGTATGGAAGTCACAACTACACAGAGATTTCTCAGCCTACAAATTGTGTCTATA

>In-frame_ENST00000267750_ENST00000377491_TCGA-HU-A4GN-01A_EMC4_chr15_34520047_+_PARK7_chr1_8037712_length(amino acids)=200AA_start in transcript=116_stop in transcript=718
MTAQGGLVANRGRRFKWAIELSGPGGGSRGRSDRGSGQGDSLYPVGYLDKQVPDTSVQETDRILVEKRCWDIALGPLKQIPMNLFIMYMA
GNTISIFPTMMVCMMAWRPIQALMAISASPTALLAHEIGFGSKVTTHPLAKDKMMNGGHYTYSENRVEKDGLILTSRGPGTSFEFALAIV

--------------------------------------------------------------
>In-frame_ENST00000267750_ENST00000377488_TCGA-HU-A4GN-01A_EMC4_chr15_34520047_+_PARK7_chr1_8037712_length(transcript)=776nt_BP=471nt
ATTCACGCGCCGGAAGTGCATTTGCAGAGTGAGACAAAGCGGAGAACGCTGGTGGGCCTGTTGTGGAGTACGCTTTGGACTGAGAAGCAT
CGAGGCTATAGGACGCAGCTGTTGCCATGACGGCCCAGGGGGGCCTGGTGGCTAACCGAGGCCGGCGCTTCAAGTGGGCCATTGAGCTAA
GCGGGCCTGGAGGAGGCAGCAGGGGTCGAAGTGACCGGGGCAGTGGCCAGGGAGACTCGCTCTACCCAGTCGGTTACTTGGACAAGCAAG
TGCCTGATACCAGCGTGCAAGAGACAGACCGGATCCTGGTGGAGAAGCGCTGCTGGGACATCGCCTTGGGTCCCCTCAAACAGATTCCCA
TGAATCTCTTCATCATGTACATGGCAGGCAATACTATCTCCATCTTCCCTACTATGATGGTGTGTATGATGGCCTGGCGACCCATTCAGG
CACTTATGGCCATTTCAGCCAGTCCTACTGCTCTGTTGGCTCATGAAATAGGTTTTGGAAGTAAAGTTACAACACACCCTCTTGCTAAAG
ACAAAATGATGAATGGAGGTCATTACACCTACTCTGAGAATCGTGTGGAAAAAGACGGCCTGATTCTTACAAGCCGGGGGCCTGGGACCA
GCTTCGAGTTTGCGCTTGCAATTGTTGAAGCCCTGAATGGCAAGGAGGTGGCGGCTCAAGTGAAGGCTCCACTTGTTCTTAAAGACTAGA

>In-frame_ENST00000267750_ENST00000377488_TCGA-HU-A4GN-01A_EMC4_chr15_34520047_+_PARK7_chr1_8037712_length(amino acids)=200AA_start in transcript=116_stop in transcript=718
MTAQGGLVANRGRRFKWAIELSGPGGGSRGRSDRGSGQGDSLYPVGYLDKQVPDTSVQETDRILVEKRCWDIALGPLKQIPMNLFIMYMA
GNTISIFPTMMVCMMAWRPIQALMAISASPTALLAHEIGFGSKVTTHPLAKDKMMNGGHYTYSENRVEKDGLILTSRGPGTSFEFALAIV

--------------------------------------------------------------
>In-frame_ENST00000249209_ENST00000338639_TCGA-HU-A4GN-01A_EMC4_chr15_34520047_+_PARK7_chr1_8037712_length(transcript)=930nt_BP=457nt
AGTGCATTTGCAGAGTGAGACAAAGCGGAGAACGCTGGTGGGCCTGTTGTGGAGTACGCTTTGGACTGAGAAGCATCGAGGCTATAGGAC
GCAGCTGTTGCCATGACGGCCCAGGGGGGCCTGGTGGCTAACCGAGGCCGGCGCTTCAAGTGGGCCATTGAGCTAAGCGGGCCTGGAGGA
GGCAGCAGGGGTCGAAGTGACCGGGGCAGTGGCCAGGGAGACTCGCTCTACCCAGTCGGTTACTTGGACAAGCAAGTGCCTGATACCAGC
GTGCAAGAGACAGACCGGATCCTGGTGGAGAAGCGCTGCTGGGACATCGCCTTGGGTCCCCTCAAACAGATTCCCATGAATCTCTTCATC
ATGTACATGGCAGGCAATACTATCTCCATCTTCCCTACTATGATGGTGTGTATGATGGCCTGGCGACCCATTCAGGCACTTATGGCCATT
TCAGCCAGTCCTACTGCTCTGTTGGCTCATGAAATAGGTTTTGGAAGTAAAGTTACAACACACCCTCTTGCTAAAGACAAAATGATGAAT
GGAGGTCATTACACCTACTCTGAGAATCGTGTGGAAAAAGACGGCCTGATTCTTACAAGCCGGGGGCCTGGGACCAGCTTCGAGTTTGCG
CTTGCAATTGTTGAAGCCCTGAATGGCAAGGAGGTGGCGGCTCAAGTGAAGGCTCCACTTGTTCTTAAAGACTAGAGCAGCGAACTGCGA
CGATCACTTAGAGAAACAGGCCGTTAGGAATCCATTCTCACTGTGTTCGCTCTAAACAAAACAGTGGTAGGTTAATGTGTTCAGAAGTCG
CTGTCCTTACTACTTTTGCGGAAGTATGGAAGTCACAACTACACAGAGATTTCTCAGCCTACAAATTGTGTCTATACATTTCTAAGCCTT

>In-frame_ENST00000249209_ENST00000338639_TCGA-HU-A4GN-01A_EMC4_chr15_34520047_+_PARK7_chr1_8037712_length(amino acids)=200AA_start in transcript=102_stop in transcript=704
MTAQGGLVANRGRRFKWAIELSGPGGGSRGRSDRGSGQGDSLYPVGYLDKQVPDTSVQETDRILVEKRCWDIALGPLKQIPMNLFIMYMA
GNTISIFPTMMVCMMAWRPIQALMAISASPTALLAHEIGFGSKVTTHPLAKDKMMNGGHYTYSENRVEKDGLILTSRGPGTSFEFALAIV

--------------------------------------------------------------
>In-frame_ENST00000249209_ENST00000493678_TCGA-HU-A4GN-01A_EMC4_chr15_34520047_+_PARK7_chr1_8037712_length(transcript)=1156nt_BP=457nt
AGTGCATTTGCAGAGTGAGACAAAGCGGAGAACGCTGGTGGGCCTGTTGTGGAGTACGCTTTGGACTGAGAAGCATCGAGGCTATAGGAC
GCAGCTGTTGCCATGACGGCCCAGGGGGGCCTGGTGGCTAACCGAGGCCGGCGCTTCAAGTGGGCCATTGAGCTAAGCGGGCCTGGAGGA
GGCAGCAGGGGTCGAAGTGACCGGGGCAGTGGCCAGGGAGACTCGCTCTACCCAGTCGGTTACTTGGACAAGCAAGTGCCTGATACCAGC
GTGCAAGAGACAGACCGGATCCTGGTGGAGAAGCGCTGCTGGGACATCGCCTTGGGTCCCCTCAAACAGATTCCCATGAATCTCTTCATC
ATGTACATGGCAGGCAATACTATCTCCATCTTCCCTACTATGATGGTGTGTATGATGGCCTGGCGACCCATTCAGGCACTTATGGCCATT
TCAGCCAGTCCTACTGCTCTGTTGGCTCATGAAATAGGTTTTGGAAGTAAAGTTACAACACACCCTCTTGCTAAAGACAAAATGATGAAT
GGAGGTCATTACACCTACTCTGAGAATCGTGTGGAAAAAGACGGCCTGATTCTTACAAGCCGGGGGCCTGGGACCAGCTTCGAGTTTGCG
CTTGCAATTGTTGAAGCCCTGAATGGCAAGGAGGTGGCGGCTCAAGTGAAGGCTCCACTTGTTCTTAAAGACTAGAGCAGCGAACTGCGA
CGATCACTTAGAGAAACAGGCCGTTAGGAATCCATTCTCACTGTGTTCGCTCTAAACAAAACAGTGGTAGGTTAATGTGTTCAGAAGTCG
CTGTCCTTACTACTTTTGCGGAAGTATGGAAGTCACAACTACACAGAGATTTCTCAGCCTACAAATTGTGTCTATACATTTCTAAGCCTT
GTTTGCAGAATAAACAGGGCATTTAGCAAACTACTGATTGTTTCTTGTTTTGTCTCTCATTTCTTTTGTGAAATTAAATTCCGTATCACC
TTCATTTGCAGCTCTTAACTGTCCATATGGCACTGAAATAAAAGAACAGTGACCACATTTTACACAGCAAGGAGGAAAGGCATACAAACA

>In-frame_ENST00000249209_ENST00000493678_TCGA-HU-A4GN-01A_EMC4_chr15_34520047_+_PARK7_chr1_8037712_length(amino acids)=200AA_start in transcript=102_stop in transcript=704
MTAQGGLVANRGRRFKWAIELSGPGGGSRGRSDRGSGQGDSLYPVGYLDKQVPDTSVQETDRILVEKRCWDIALGPLKQIPMNLFIMYMA
GNTISIFPTMMVCMMAWRPIQALMAISASPTALLAHEIGFGSKVTTHPLAKDKMMNGGHYTYSENRVEKDGLILTSRGPGTSFEFALAIV

--------------------------------------------------------------
>In-frame_ENST00000249209_ENST00000377493_TCGA-HU-A4GN-01A_EMC4_chr15_34520047_+_PARK7_chr1_8037712_length(transcript)=932nt_BP=457nt
AGTGCATTTGCAGAGTGAGACAAAGCGGAGAACGCTGGTGGGCCTGTTGTGGAGTACGCTTTGGACTGAGAAGCATCGAGGCTATAGGAC
GCAGCTGTTGCCATGACGGCCCAGGGGGGCCTGGTGGCTAACCGAGGCCGGCGCTTCAAGTGGGCCATTGAGCTAAGCGGGCCTGGAGGA
GGCAGCAGGGGTCGAAGTGACCGGGGCAGTGGCCAGGGAGACTCGCTCTACCCAGTCGGTTACTTGGACAAGCAAGTGCCTGATACCAGC
GTGCAAGAGACAGACCGGATCCTGGTGGAGAAGCGCTGCTGGGACATCGCCTTGGGTCCCCTCAAACAGATTCCCATGAATCTCTTCATC
ATGTACATGGCAGGCAATACTATCTCCATCTTCCCTACTATGATGGTGTGTATGATGGCCTGGCGACCCATTCAGGCACTTATGGCCATT
TCAGCCAGTCCTACTGCTCTGTTGGCTCATGAAATAGGTTTTGGAAGTAAAGTTACAACACACCCTCTTGCTAAAGACAAAATGATGAAT
GGAGGTCATTACACCTACTCTGAGAATCGTGTGGAAAAAGACGGCCTGATTCTTACAAGCCGGGGGCCTGGGACCAGCTTCGAGTTTGCG
CTTGCAATTGTTGAAGCCCTGAATGGCAAGGAGGTGGCGGCTCAAGTGAAGGCTCCACTTGTTCTTAAAGACTAGAGCAGCGAACTGCGA
CGATCACTTAGAGAAACAGGCCGTTAGGAATCCATTCTCACTGTGTTCGCTCTAAACAAAACAGTGGTAGGTTAATGTGTTCAGAAGTCG
CTGTCCTTACTACTTTTGCGGAAGTATGGAAGTCACAACTACACAGAGATTTCTCAGCCTACAAATTGTGTCTATACATTTCTAAGCCTT

>In-frame_ENST00000249209_ENST00000377493_TCGA-HU-A4GN-01A_EMC4_chr15_34520047_+_PARK7_chr1_8037712_length(amino acids)=200AA_start in transcript=102_stop in transcript=704
MTAQGGLVANRGRRFKWAIELSGPGGGSRGRSDRGSGQGDSLYPVGYLDKQVPDTSVQETDRILVEKRCWDIALGPLKQIPMNLFIMYMA
GNTISIFPTMMVCMMAWRPIQALMAISASPTALLAHEIGFGSKVTTHPLAKDKMMNGGHYTYSENRVEKDGLILTSRGPGTSFEFALAIV

--------------------------------------------------------------
>In-frame_ENST00000249209_ENST00000377491_TCGA-HU-A4GN-01A_EMC4_chr15_34520047_+_PARK7_chr1_8037712_length(transcript)=901nt_BP=457nt
AGTGCATTTGCAGAGTGAGACAAAGCGGAGAACGCTGGTGGGCCTGTTGTGGAGTACGCTTTGGACTGAGAAGCATCGAGGCTATAGGAC
GCAGCTGTTGCCATGACGGCCCAGGGGGGCCTGGTGGCTAACCGAGGCCGGCGCTTCAAGTGGGCCATTGAGCTAAGCGGGCCTGGAGGA
GGCAGCAGGGGTCGAAGTGACCGGGGCAGTGGCCAGGGAGACTCGCTCTACCCAGTCGGTTACTTGGACAAGCAAGTGCCTGATACCAGC
GTGCAAGAGACAGACCGGATCCTGGTGGAGAAGCGCTGCTGGGACATCGCCTTGGGTCCCCTCAAACAGATTCCCATGAATCTCTTCATC
ATGTACATGGCAGGCAATACTATCTCCATCTTCCCTACTATGATGGTGTGTATGATGGCCTGGCGACCCATTCAGGCACTTATGGCCATT
TCAGCCAGTCCTACTGCTCTGTTGGCTCATGAAATAGGTTTTGGAAGTAAAGTTACAACACACCCTCTTGCTAAAGACAAAATGATGAAT
GGAGGTCATTACACCTACTCTGAGAATCGTGTGGAAAAAGACGGCCTGATTCTTACAAGCCGGGGGCCTGGGACCAGCTTCGAGTTTGCG
CTTGCAATTGTTGAAGCCCTGAATGGCAAGGAGGTGGCGGCTCAAGTGAAGGCTCCACTTGTTCTTAAAGACTAGAGCAGCGAACTGCGA
CGATCACTTAGAGAAACAGGCCGTTAGGAATCCATTCTCACTGTGTTCGCTCTAAACAAAACAGTGGTAGGTTAATGTGTTCAGAAGTCG
CTGTCCTTACTACTTTTGCGGAAGTATGGAAGTCACAACTACACAGAGATTTCTCAGCCTACAAATTGTGTCTATACATTTCTAAGCCTT

>In-frame_ENST00000249209_ENST00000377491_TCGA-HU-A4GN-01A_EMC4_chr15_34520047_+_PARK7_chr1_8037712_length(amino acids)=200AA_start in transcript=102_stop in transcript=704
MTAQGGLVANRGRRFKWAIELSGPGGGSRGRSDRGSGQGDSLYPVGYLDKQVPDTSVQETDRILVEKRCWDIALGPLKQIPMNLFIMYMA
GNTISIFPTMMVCMMAWRPIQALMAISASPTALLAHEIGFGSKVTTHPLAKDKMMNGGHYTYSENRVEKDGLILTSRGPGTSFEFALAIV

--------------------------------------------------------------
>In-frame_ENST00000249209_ENST00000377488_TCGA-HU-A4GN-01A_EMC4_chr15_34520047_+_PARK7_chr1_8037712_length(transcript)=762nt_BP=457nt
AGTGCATTTGCAGAGTGAGACAAAGCGGAGAACGCTGGTGGGCCTGTTGTGGAGTACGCTTTGGACTGAGAAGCATCGAGGCTATAGGAC
GCAGCTGTTGCCATGACGGCCCAGGGGGGCCTGGTGGCTAACCGAGGCCGGCGCTTCAAGTGGGCCATTGAGCTAAGCGGGCCTGGAGGA
GGCAGCAGGGGTCGAAGTGACCGGGGCAGTGGCCAGGGAGACTCGCTCTACCCAGTCGGTTACTTGGACAAGCAAGTGCCTGATACCAGC
GTGCAAGAGACAGACCGGATCCTGGTGGAGAAGCGCTGCTGGGACATCGCCTTGGGTCCCCTCAAACAGATTCCCATGAATCTCTTCATC
ATGTACATGGCAGGCAATACTATCTCCATCTTCCCTACTATGATGGTGTGTATGATGGCCTGGCGACCCATTCAGGCACTTATGGCCATT
TCAGCCAGTCCTACTGCTCTGTTGGCTCATGAAATAGGTTTTGGAAGTAAAGTTACAACACACCCTCTTGCTAAAGACAAAATGATGAAT
GGAGGTCATTACACCTACTCTGAGAATCGTGTGGAAAAAGACGGCCTGATTCTTACAAGCCGGGGGCCTGGGACCAGCTTCGAGTTTGCG
CTTGCAATTGTTGAAGCCCTGAATGGCAAGGAGGTGGCGGCTCAAGTGAAGGCTCCACTTGTTCTTAAAGACTAGAGCAGCGAACTGCGA

>In-frame_ENST00000249209_ENST00000377488_TCGA-HU-A4GN-01A_EMC4_chr15_34520047_+_PARK7_chr1_8037712_length(amino acids)=200AA_start in transcript=102_stop in transcript=704
MTAQGGLVANRGRRFKWAIELSGPGGGSRGRSDRGSGQGDSLYPVGYLDKQVPDTSVQETDRILVEKRCWDIALGPLKQIPMNLFIMYMA
GNTISIFPTMMVCMMAWRPIQALMAISASPTALLAHEIGFGSKVTTHPLAKDKMMNGGHYTYSENRVEKDGLILTSRGPGTSFEFALAIV

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Fusion Gene PPI Analysis for EMC4-PARK7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EMC4-PARK7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EMC4-PARK7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePARK7C1853445PARKINSON DISEASE 7, AUTOSOMAL RECESSIVE EARLY-ONSET13CTD_human;GENOMICS_ENGLAND;UNIPROT
TgenePARK7C0030567Parkinson Disease9CTD_human
TgenePARK7C0242422Parkinsonian Disorders2CTD_human
TgenePARK7C0242423Ramsay Hunt Paralysis Syndrome2CTD_human
TgenePARK7C0752097Autosomal Dominant Juvenile Parkinson Disease2CTD_human
TgenePARK7C0752098Autosomal Dominant Parkinsonism2CTD_human
TgenePARK7C0752100Autosomal Recessive Parkinsonism2CTD_human
TgenePARK7C0752101Parkinsonism, Experimental2CTD_human
TgenePARK7C0752104Familial Juvenile Parkinsonism2CTD_human
TgenePARK7C0752105Parkinsonism, Juvenile2CTD_human
TgenePARK7C1868675PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE2CTD_human
TgenePARK7C0001787Osteoporosis, Age-Related1CTD_human
TgenePARK7C0019193Hepatitis, Toxic1CTD_human
TgenePARK7C0029456Osteoporosis1CTD_human
TgenePARK7C0029459Osteoporosis, Senile1CTD_human
TgenePARK7C0206160Reticulocytosis1CTD_human
TgenePARK7C0520459Necrotizing Enterocolitis1CTD_human
TgenePARK7C0751406Post-Traumatic Osteoporosis1CTD_human
TgenePARK7C0860207Drug-Induced Liver Disease1CTD_human
TgenePARK7C1262760Hepatitis, Drug-Induced1CTD_human
TgenePARK7C2239176Liver carcinoma1CTD_human
TgenePARK7C3658290Drug-Induced Acute Liver Injury1CTD_human
TgenePARK7C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgenePARK7C4279912Chemically-Induced Liver Toxicity1CTD_human