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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ENAH-SCCPDH (FusionGDB2 ID:26507)

Fusion Gene Summary for ENAH-SCCPDH

check button Fusion gene summary
Fusion gene informationFusion gene name: ENAH-SCCPDH
Fusion gene ID: 26507
HgeneTgene
Gene symbol

ENAH

SCCPDH

Gene ID

55740

51097

Gene nameENAH actin regulatorsaccharopine dehydrogenase (putative)
SynonymsENA|MENA|NDPP1CGI-49|NET11
Cytomap

1q42.12

1q44

Type of geneprotein-codingprotein-coding
Descriptionprotein enabled homologenabled homologmammalian enabled variant 11amammalian enabled variant pansaccharopine dehydrogenase-like oxidoreductaseepididymis secretory sperm binding proteinprobable saccharopine dehydrogenase
Modification date2020031320200313
UniProtAcc

Q8N8S7

.
Ensembl transtripts involved in fusion geneENST00000366844, ENST00000366843, 
ENST00000284563, ENST00000391874, 
ENST00000366510, 
Fusion gene scores* DoF score12 X 11 X 8=10568 X 11 X 7=616
# samples 1611
** MAII scorelog2(16/1056*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/616*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ENAH [Title/Abstract] AND SCCPDH [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointENAH(225840388)-SCCPDH(246921528), # samples:2
ENAH(225840388)-SCCPDH(246907378), # samples:2
Anticipated loss of major functional domain due to fusion event.ENAH-SCCPDH seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ENAH (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SCCPDH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-W3-A824-06AENAHchr1

225840388

-SCCPDHchr1

246921528

+
ChimerDB4SKCMTCGA-W3-A824-06AENAHchr1

225840388

-SCCPDHchr1

246921528

+
ChimerDB4SKCMTCGA-W3-A824-06AENAHchr1

225840388

-SCCPDHchr1

246907378

+
ChimerDB4SKCMTCGA-W3-A824-06AENAHchr1

225840388

-SCCPDHchr1

246922336

+
ChimerDB4SKCMTCGA-W3-A824-06AENAHchr1

225840388

-SCCPDHchr1

246907378

+


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Fusion Gene ORF analysis for ENAH-SCCPDH

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000366844ENST00000366510ENAHchr1

225840388

-SCCPDHchr1

246921528

+
In-frameENST00000366843ENST00000366510ENAHchr1

225840388

-SCCPDHchr1

246921528

+
In-frameENST00000284563ENST00000366510ENAHchr1

225840388

-SCCPDHchr1

246921528

+
intron-3CDSENST00000391874ENST00000366510ENAHchr1

225840388

-SCCPDHchr1

246921528

+
Frame-shiftENST00000366844ENST00000366510ENAHchr1

225840388

-SCCPDHchr1

246907378

+
Frame-shiftENST00000366843ENST00000366510ENAHchr1

225840388

-SCCPDHchr1

246907378

+
Frame-shiftENST00000284563ENST00000366510ENAHchr1

225840388

-SCCPDHchr1

246907378

+
intron-3CDSENST00000391874ENST00000366510ENAHchr1

225840388

-SCCPDHchr1

246907378

+
Frame-shiftENST00000366844ENST00000366510ENAHchr1

225840388

-SCCPDHchr1

246922336

+
Frame-shiftENST00000366843ENST00000366510ENAHchr1

225840388

-SCCPDHchr1

246922336

+
Frame-shiftENST00000284563ENST00000366510ENAHchr1

225840388

-SCCPDHchr1

246922336

+
intron-3CDSENST00000391874ENST00000366510ENAHchr1

225840388

-SCCPDHchr1

246922336

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000366844ENAHchr1225840388-ENST00000366510SCCPDHchr1246921528+20204571991182327
ENST00000366843ENAHchr1225840388-ENST00000366510SCCPDHchr1246921528+19233601021085327
ENST00000284563ENAHchr1225840388-ENST00000366510SCCPDHchr1246921528+15943110756248

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000366844ENST00000366510ENAHchr1225840388-SCCPDHchr1246921528+0.0018674440.9981325
ENST00000366843ENST00000366510ENAHchr1225840388-SCCPDHchr1246921528+0.0013991790.9986008
ENST00000284563ENST00000366510ENAHchr1225840388-SCCPDHchr1246921528+0.0013411660.9986588

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Fusion Genomic Features for ENAH-SCCPDH


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ENAHchr1225840387-SCCPDHchr1246921527+0.0003630640.9996369
ENAHchr1225840387-SCCPDHchr1246922335+8.49E-060.99999154
ENAHchr1225840387-SCCPDHchr1246907377+8.63E-091
ENAHchr1225840387-SCCPDHchr1246921527+0.0003630640.9996369
ENAHchr1225840387-SCCPDHchr1246922335+8.49E-060.99999154
ENAHchr1225840387-SCCPDHchr1246907377+8.63E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ENAH-SCCPDH


check button Go to

FGviewer for the breakpoints of chr1:225840388-chr1:246921528

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ENAH

Q8N8S7

.
FUNCTION: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). {ECO:0000250, ECO:0000269|PubMed:11696321, ECO:0000269|PubMed:18158903}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114135_2651.6666666666666667571.0Coiled coilOntology_term=ECO:0000255
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114557_5871.6666666666666667571.0Coiled coilOntology_term=ECO:0000255
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115135_2651.6666666666666667592.0Coiled coilOntology_term=ECO:0000255
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115557_5871.6666666666666667592.0Coiled coilOntology_term=ECO:0000255
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114310_3731.6666666666666667571.0Compositional biasNote=Pro-rich
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115310_3731.6666666666666667592.0Compositional biasNote=Pro-rich
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-1141_1111.6666666666666667571.0DomainWH1
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-1151_1111.6666666666666667592.0DomainWH1
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114400_4031.6666666666666667571.0MotifNote=KLKR
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115400_4031.6666666666666667592.0MotifNote=KLKR
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114156_2001.6666666666666667571.0RegionNote=9 X 5 AA tandem repeats of [LMQ]-E-[QR]-E-[QR]
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114391_4111.6666666666666667571.0RegionNote=EVH2 block A
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114391_5881.6666666666666667571.0RegionNote=EVH2
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114442_4591.6666666666666667571.0RegionNote=EVH2 block B
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114554_5881.6666666666666667571.0RegionNote=EVH2 block C
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115156_2001.6666666666666667592.0RegionNote=9 X 5 AA tandem repeats of [LMQ]-E-[QR]-E-[QR]
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115391_4111.6666666666666667592.0RegionNote=EVH2 block A
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115391_5881.6666666666666667592.0RegionNote=EVH2
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115442_4591.6666666666666667592.0RegionNote=EVH2 block B
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115554_5881.6666666666666667592.0RegionNote=EVH2 block C
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114156_1601.6666666666666667571.0RepeatNote=1
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114161_1651.6666666666666667571.0RepeatNote=2
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114166_1701.6666666666666667571.0RepeatNote=3
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114171_1751.6666666666666667571.0RepeatNote=4
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114176_1801.6666666666666667571.0RepeatNote=5
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114181_1851.6666666666666667571.0RepeatNote=6
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114186_1901.6666666666666667571.0RepeatNote=7
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114191_1951.6666666666666667571.0RepeatNote=8
HgeneENAHchr1:225840388chr1:246921528ENST00000366843-114196_2001.6666666666666667571.0RepeatNote=9
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115156_1601.6666666666666667592.0RepeatNote=1
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115161_1651.6666666666666667592.0RepeatNote=2
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115166_1701.6666666666666667592.0RepeatNote=3
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115171_1751.6666666666666667592.0RepeatNote=4
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115176_1801.6666666666666667592.0RepeatNote=5
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115181_1851.6666666666666667592.0RepeatNote=6
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115186_1901.6666666666666667592.0RepeatNote=7
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115191_1951.6666666666666667592.0RepeatNote=8
HgeneENAHchr1:225840388chr1:246921528ENST00000366844-115196_2001.6666666666666667592.0RepeatNote=9


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Fusion Gene Sequence for ENAH-SCCPDH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000366844_ENST00000366510_TCGA-W3-A824-06A_ENAH_chr1_225840388_-_SCCPDH_chr1_246921528_length(transcript)=2020nt_BP=457nt
GGTTCCTCGCGGCGATCCCGACTCTCCTCCCGCGGCTGCAGCAGCTGCCGGTTGCACACGGCCTCGGCGGCGGCGCGGCGAGCGCGGGCC
TGTGGAGCGGCGGCCGGGCGCGCGGCCCCGGCGGGCACCCCTCAGAGGGCGGCCGAGGAAGCTCCGGGAGGAGGAGCAGGACCACGAGGA
GGTGGGAGGCGGCGGCCGCCTGGGGACCAGCTCCGCGCCTCGGCCTCTCCGCCCCCTCCCCAGCCTTTCTCTCGCCCTCTTCTCCCACAC
TCCCGGCCGGCGCCTCGGCTTTGTGCGAGGAGATGGTGTAGCCCCCTGGCCGCCGAAGGAGGAGCCGGACACTTGTCTCCCGTCTCCGAG
CTGCTCCCCACCCCTGGAGGAGAGACCCCCCCCTCGGCTCGGCGCCTTCTGCGTCTCCCGGCTGGTGGGGAAGCCTCTGCGCCGCCGGCA
CCATGAGGGGTTGAGCATTCATGATGGTACCTGGAAGTCAGCAATTTATGGTTTTGGAGATCAGAGTAATTTGAGAAAACTAAGAAATGT
ATCAAATCTGAAACCTGTCCCGCTCATTGGTCCAAAATTGAAGAGAAGGTGGCCAATTTCTTATTGTCGGGAACTCAAAGGTTATTCCAT
TCCTTTTATGGGATCTGATGTGTCTGTTGTAAGGAGGACTCAACGTTACTTGTATGAAAATTTAGAGGAATCACCAGTTCAGTATGCTGC
GTATGTAACTGTGGGAGGCATCACCTCTGTTATTAAGCTGATGTTTGCAGGACTTTTCTTTTTGTTCTTTGTGAGGTTTGGAATTGGAAG
GCAACTTCTCATAAAATTCCCATGGTTCTTCTCCTTTGGCTATTTTTCAAAACAAGGCCCAACACAAAAACAGATTGATGCTGCCTCATT
CACGCTGACATTCTTTGGTCAAGGATACAGCCAAGGCACTGGTACAGATAAGAACAAACCAAATATCAAAATTTGTACTCAGGTGAAAGG
ACCAGAGGCTGGCTATGTGGCTACCCCCATAGCTATGGTTCAGGCAGCCATGACTCTTCTAAGTGATGCTTCTCATCTGCCTAAGGCGGG
CGGGGTCTTCACACCTGGAGCAGCTTTTTCCAAAACAAAGTTGATTGACAGACTCAACAAACACGGTATTGAGTTTAGTGTTATTAGCAG
CTCTGAAGTCTAAACACTGGAAGAATTAACTGAAGTCATAACGTGCGTGAATTAACAGCTTCTCTATTTGATATTTGAAATTCTTCTGTA
AGCCTGTCTGAGTGTATGTGGAAACGATTGTCAAATCTAAAATATCTATATATTAAAAAGTAGGAAATTGTCCTAGCTTACCCTAAATTT
CAAATCTGAGTTGATTTTGTGATTTTATTGCTTATAACAGAGAACTCATATTTGACATATTTTTTTCATTGATGTGTTCCTGGTAGATTT
TCACGAATGAGCTGGCAGGTCTAATGGGGGAGGCGGCGTCCCAGTCTGTGTTGCAGCAGCATTCTCATCGGGGGTGCGCACACCATCGTT
ACTGTCGGGCAGTAACTGCCGCTTGCCTTGCCGCAGTAGGAGGGAAATCTCACCTTCCTTCCACATACTGTCTTGAGCCTTTGCTAAATT
AAACTGCACTTTTTGCTATTTTTGCCTAGTTTTTCGCCAATCTACACTGATTTTGGACTGTTACCTAAGTTGAAAAATAAAAGGTTGTCA
ATCGAATGGTGGTTTAATGTTTGGACCTGCCGATGTATTTGTATAGTGGTAGAAACATGCTGCTTAAGTGGCCTAACCTGTTTCTTGCCA
ATAAGTAGGCTTATCATTTTATCTTTACGTAATTCTATATCTGTGACTAGGTTTTTAAGGATACAGCTTATAAGTTGCTATCAATTTTCA
CTACCTAAGCAGAATTTTTCTCTAATTTACTTTTTGTATTTTAACTAGGTTTTACATGGAAGCCCTAAAATAAGGCAAAAGACTTTTTCT

>In-frame_ENST00000366844_ENST00000366510_TCGA-W3-A824-06A_ENAH_chr1_225840388_-_SCCPDH_chr1_246921528_length(amino acids)=327AA_start in transcript=199_stop in transcript=1182
MGTSSAPRPLRPLPSLSLALFSHTPGRRLGFVRGDGVAPWPPKEEPDTCLPSPSCSPPLEERPPPRLGAFCVSRLVGKPLRRRHHEGLSI
HDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGG
ITSVIKLMFAGLFFLFFVRFGIGRQLLIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYV

--------------------------------------------------------------
>In-frame_ENST00000366843_ENST00000366510_TCGA-W3-A824-06A_ENAH_chr1_225840388_-_SCCPDH_chr1_246921528_length(transcript)=1923nt_BP=360nt
CGGCGGCCGGGCGCGCGGCCCCGGCGGGCACCCCTCAGAGGGCGGCCGAGGAAGCTCCGGGAGGAGGAGCAGGACCACGAGGAGGTGGGA
GGCGGCGGCCGCCTGGGGACCAGCTCCGCGCCTCGGCCTCTCCGCCCCCTCCCCAGCCTTTCTCTCGCCCTCTTCTCCCACACTCCCGGC
CGGCGCCTCGGCTTTGTGCGAGGAGATGGTGTAGCCCCCTGGCCGCCGAAGGAGGAGCCGGACACTTGTCTCCCGTCTCCGAGCTGCTCC
CCACCCCTGGAGGAGAGACCCCCCCCTCGGCTCGGCGCCTTCTGCGTCTCCCGGCTGGTGGGGAAGCCTCTGCGCCGCCGGCACCATGAG
GGGTTGAGCATTCATGATGGTACCTGGAAGTCAGCAATTTATGGTTTTGGAGATCAGAGTAATTTGAGAAAACTAAGAAATGTATCAAAT
CTGAAACCTGTCCCGCTCATTGGTCCAAAATTGAAGAGAAGGTGGCCAATTTCTTATTGTCGGGAACTCAAAGGTTATTCCATTCCTTTT
ATGGGATCTGATGTGTCTGTTGTAAGGAGGACTCAACGTTACTTGTATGAAAATTTAGAGGAATCACCAGTTCAGTATGCTGCGTATGTA
ACTGTGGGAGGCATCACCTCTGTTATTAAGCTGATGTTTGCAGGACTTTTCTTTTTGTTCTTTGTGAGGTTTGGAATTGGAAGGCAACTT
CTCATAAAATTCCCATGGTTCTTCTCCTTTGGCTATTTTTCAAAACAAGGCCCAACACAAAAACAGATTGATGCTGCCTCATTCACGCTG
ACATTCTTTGGTCAAGGATACAGCCAAGGCACTGGTACAGATAAGAACAAACCAAATATCAAAATTTGTACTCAGGTGAAAGGACCAGAG
GCTGGCTATGTGGCTACCCCCATAGCTATGGTTCAGGCAGCCATGACTCTTCTAAGTGATGCTTCTCATCTGCCTAAGGCGGGCGGGGTC
TTCACACCTGGAGCAGCTTTTTCCAAAACAAAGTTGATTGACAGACTCAACAAACACGGTATTGAGTTTAGTGTTATTAGCAGCTCTGAA
GTCTAAACACTGGAAGAATTAACTGAAGTCATAACGTGCGTGAATTAACAGCTTCTCTATTTGATATTTGAAATTCTTCTGTAAGCCTGT
CTGAGTGTATGTGGAAACGATTGTCAAATCTAAAATATCTATATATTAAAAAGTAGGAAATTGTCCTAGCTTACCCTAAATTTCAAATCT
GAGTTGATTTTGTGATTTTATTGCTTATAACAGAGAACTCATATTTGACATATTTTTTTCATTGATGTGTTCCTGGTAGATTTTCACGAA
TGAGCTGGCAGGTCTAATGGGGGAGGCGGCGTCCCAGTCTGTGTTGCAGCAGCATTCTCATCGGGGGTGCGCACACCATCGTTACTGTCG
GGCAGTAACTGCCGCTTGCCTTGCCGCAGTAGGAGGGAAATCTCACCTTCCTTCCACATACTGTCTTGAGCCTTTGCTAAATTAAACTGC
ACTTTTTGCTATTTTTGCCTAGTTTTTCGCCAATCTACACTGATTTTGGACTGTTACCTAAGTTGAAAAATAAAAGGTTGTCAATCGAAT
GGTGGTTTAATGTTTGGACCTGCCGATGTATTTGTATAGTGGTAGAAACATGCTGCTTAAGTGGCCTAACCTGTTTCTTGCCAATAAGTA
GGCTTATCATTTTATCTTTACGTAATTCTATATCTGTGACTAGGTTTTTAAGGATACAGCTTATAAGTTGCTATCAATTTTCACTACCTA
AGCAGAATTTTTCTCTAATTTACTTTTTGTATTTTAACTAGGTTTTACATGGAAGCCCTAAAATAAGGCAAAAGACTTTTTCTTTTGTAA

>In-frame_ENST00000366843_ENST00000366510_TCGA-W3-A824-06A_ENAH_chr1_225840388_-_SCCPDH_chr1_246921528_length(amino acids)=327AA_start in transcript=102_stop in transcript=1085
MGTSSAPRPLRPLPSLSLALFSHTPGRRLGFVRGDGVAPWPPKEEPDTCLPSPSCSPPLEERPPPRLGAFCVSRLVGKPLRRRHHEGLSI
HDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESPVQYAAYVTVGG
ITSVIKLMFAGLFFLFFVRFGIGRQLLIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKICTQVKGPEAGYV

--------------------------------------------------------------
>In-frame_ENST00000284563_ENST00000366510_TCGA-W3-A824-06A_ENAH_chr1_225840388_-_SCCPDH_chr1_246921528_length(transcript)=1594nt_BP=31nt
GGGGAAGCCTCTGCGCCGCCGGCACCATGAGGGGTTGAGCATTCATGATGGTACCTGGAAGTCAGCAATTTATGGTTTTGGAGATCAGAG
TAATTTGAGAAAACTAAGAAATGTATCAAATCTGAAACCTGTCCCGCTCATTGGTCCAAAATTGAAGAGAAGGTGGCCAATTTCTTATTG
TCGGGAACTCAAAGGTTATTCCATTCCTTTTATGGGATCTGATGTGTCTGTTGTAAGGAGGACTCAACGTTACTTGTATGAAAATTTAGA
GGAATCACCAGTTCAGTATGCTGCGTATGTAACTGTGGGAGGCATCACCTCTGTTATTAAGCTGATGTTTGCAGGACTTTTCTTTTTGTT
CTTTGTGAGGTTTGGAATTGGAAGGCAACTTCTCATAAAATTCCCATGGTTCTTCTCCTTTGGCTATTTTTCAAAACAAGGCCCAACACA
AAAACAGATTGATGCTGCCTCATTCACGCTGACATTCTTTGGTCAAGGATACAGCCAAGGCACTGGTACAGATAAGAACAAACCAAATAT
CAAAATTTGTACTCAGGTGAAAGGACCAGAGGCTGGCTATGTGGCTACCCCCATAGCTATGGTTCAGGCAGCCATGACTCTTCTAAGTGA
TGCTTCTCATCTGCCTAAGGCGGGCGGGGTCTTCACACCTGGAGCAGCTTTTTCCAAAACAAAGTTGATTGACAGACTCAACAAACACGG
TATTGAGTTTAGTGTTATTAGCAGCTCTGAAGTCTAAACACTGGAAGAATTAACTGAAGTCATAACGTGCGTGAATTAACAGCTTCTCTA
TTTGATATTTGAAATTCTTCTGTAAGCCTGTCTGAGTGTATGTGGAAACGATTGTCAAATCTAAAATATCTATATATTAAAAAGTAGGAA
ATTGTCCTAGCTTACCCTAAATTTCAAATCTGAGTTGATTTTGTGATTTTATTGCTTATAACAGAGAACTCATATTTGACATATTTTTTT
CATTGATGTGTTCCTGGTAGATTTTCACGAATGAGCTGGCAGGTCTAATGGGGGAGGCGGCGTCCCAGTCTGTGTTGCAGCAGCATTCTC
ATCGGGGGTGCGCACACCATCGTTACTGTCGGGCAGTAACTGCCGCTTGCCTTGCCGCAGTAGGAGGGAAATCTCACCTTCCTTCCACAT
ACTGTCTTGAGCCTTTGCTAAATTAAACTGCACTTTTTGCTATTTTTGCCTAGTTTTTCGCCAATCTACACTGATTTTGGACTGTTACCT
AAGTTGAAAAATAAAAGGTTGTCAATCGAATGGTGGTTTAATGTTTGGACCTGCCGATGTATTTGTATAGTGGTAGAAACATGCTGCTTA
AGTGGCCTAACCTGTTTCTTGCCAATAAGTAGGCTTATCATTTTATCTTTACGTAATTCTATATCTGTGACTAGGTTTTTAAGGATACAG
CTTATAAGTTGCTATCAATTTTCACTACCTAAGCAGAATTTTTCTCTAATTTACTTTTTGTATTTTAACTAGGTTTTACATGGAAGCCCT

>In-frame_ENST00000284563_ENST00000366510_TCGA-W3-A824-06A_ENAH_chr1_225840388_-_SCCPDH_chr1_246921528_length(amino acids)=248AA_start in transcript=10_stop in transcript=756
MRRRHHEGLSIHDGTWKSAIYGFGDQSNLRKLRNVSNLKPVPLIGPKLKRRWPISYCRELKGYSIPFMGSDVSVVRRTQRYLYENLEESP
VQYAAYVTVGGITSVIKLMFAGLFFLFFVRFGIGRQLLIKFPWFFSFGYFSKQGPTQKQIDAASFTLTFFGQGYSQGTGTDKNKPNIKIC

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Fusion Gene PPI Analysis for ENAH-SCCPDH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ENAH-SCCPDH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ENAH-SCCPDH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneENAHC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneENAHC0026998Acute Myeloid Leukemia, M11CTD_human
HgeneENAHC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human