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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EPHA6-C11orf80 (FusionGDB2 ID:26935)

Fusion Gene Summary for EPHA6-C11orf80

check button Fusion gene summary
Fusion gene informationFusion gene name: EPHA6-C11orf80
Fusion gene ID: 26935
HgeneTgene
Gene symbol

EPHA6

C11orf80

Gene ID

285220

79703

Gene nameEPH receptor A6chromosome 11 open reading frame 80
SynonymsEHK-2|EHK2|EK12|EPA6|HEK12|PRO57066HYDM4|TOP6BL|TOPOVIBL
Cytomap

3q11.2

11q13.2

Type of geneprotein-codingprotein-coding
Descriptionephrin type-A receptor 6EPH homology kinase 2EPH-like kinase 12ephrin receptor EphA6type 2 DNA topoisomerase 6 subunit B-liketype 2 DNA topoisomerase VI subunit B-like
Modification date2020031320200313
UniProtAcc

Q9UF33

.
Ensembl transtripts involved in fusion geneENST00000470610, ENST00000389672, 
ENST00000542517, ENST00000514100, 
ENST00000502694, ENST00000442602, 
ENST00000346672, ENST00000360962, 
ENST00000527634, ENST00000540737, 
ENST00000532565, ENST00000525449, 
ENST00000527368, 
Fusion gene scores* DoF score6 X 5 X 4=12019 X 19 X 10=3610
# samples 724
** MAII scorelog2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/3610*10)=-3.91089252616601
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EPHA6 [Title/Abstract] AND C11orf80 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointEPHA6(96963131)-C11orf80(66583524), # samples:1
Anticipated loss of major functional domain due to fusion event.EPHA6-C11orf80 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
EPHA6-C11orf80 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
EPHA6-C11orf80 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across EPHA6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across C11orf80 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-LL-A7SZ-01AEPHA6chr3

96963131

-C11orf80chr11

66583524

+


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Fusion Gene ORF analysis for EPHA6-C11orf80

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000470610ENST00000346672EPHA6chr3

96963131

-C11orf80chr11

66583524

+
Frame-shiftENST00000470610ENST00000360962EPHA6chr3

96963131

-C11orf80chr11

66583524

+
Frame-shiftENST00000470610ENST00000527634EPHA6chr3

96963131

-C11orf80chr11

66583524

+
Frame-shiftENST00000470610ENST00000540737EPHA6chr3

96963131

-C11orf80chr11

66583524

+
Frame-shiftENST00000470610ENST00000532565EPHA6chr3

96963131

-C11orf80chr11

66583524

+
Frame-shiftENST00000470610ENST00000525449EPHA6chr3

96963131

-C11orf80chr11

66583524

+
5CDS-intronENST00000470610ENST00000527368EPHA6chr3

96963131

-C11orf80chr11

66583524

+
In-frameENST00000389672ENST00000346672EPHA6chr3

96963131

-C11orf80chr11

66583524

+
In-frameENST00000389672ENST00000360962EPHA6chr3

96963131

-C11orf80chr11

66583524

+
In-frameENST00000389672ENST00000527634EPHA6chr3

96963131

-C11orf80chr11

66583524

+
In-frameENST00000389672ENST00000540737EPHA6chr3

96963131

-C11orf80chr11

66583524

+
In-frameENST00000389672ENST00000532565EPHA6chr3

96963131

-C11orf80chr11

66583524

+
In-frameENST00000389672ENST00000525449EPHA6chr3

96963131

-C11orf80chr11

66583524

+
5CDS-intronENST00000389672ENST00000527368EPHA6chr3

96963131

-C11orf80chr11

66583524

+
intron-3CDSENST00000542517ENST00000346672EPHA6chr3

96963131

-C11orf80chr11

66583524

+
intron-3CDSENST00000542517ENST00000360962EPHA6chr3

96963131

-C11orf80chr11

66583524

+
intron-3CDSENST00000542517ENST00000527634EPHA6chr3

96963131

-C11orf80chr11

66583524

+
intron-3CDSENST00000542517ENST00000540737EPHA6chr3

96963131

-C11orf80chr11

66583524

+
intron-3CDSENST00000542517ENST00000532565EPHA6chr3

96963131

-C11orf80chr11

66583524

+
intron-3CDSENST00000542517ENST00000525449EPHA6chr3

96963131

-C11orf80chr11

66583524

+
intron-intronENST00000542517ENST00000527368EPHA6chr3

96963131

-C11orf80chr11

66583524

+
intron-3CDSENST00000514100ENST00000346672EPHA6chr3

96963131

-C11orf80chr11

66583524

+
intron-3CDSENST00000514100ENST00000360962EPHA6chr3

96963131

-C11orf80chr11

66583524

+
intron-3CDSENST00000514100ENST00000527634EPHA6chr3

96963131

-C11orf80chr11

66583524

+
intron-3CDSENST00000514100ENST00000540737EPHA6chr3

96963131

-C11orf80chr11

66583524

+
intron-3CDSENST00000514100ENST00000532565EPHA6chr3

96963131

-C11orf80chr11

66583524

+
intron-3CDSENST00000514100ENST00000525449EPHA6chr3

96963131

-C11orf80chr11

66583524

+
intron-intronENST00000514100ENST00000527368EPHA6chr3

96963131

-C11orf80chr11

66583524

+
intron-3CDSENST00000502694ENST00000346672EPHA6chr3

96963131

-C11orf80chr11

66583524

+
intron-3CDSENST00000502694ENST00000360962EPHA6chr3

96963131

-C11orf80chr11

66583524

+
intron-3CDSENST00000502694ENST00000527634EPHA6chr3

96963131

-C11orf80chr11

66583524

+
intron-3CDSENST00000502694ENST00000540737EPHA6chr3

96963131

-C11orf80chr11

66583524

+
intron-3CDSENST00000502694ENST00000532565EPHA6chr3

96963131

-C11orf80chr11

66583524

+
intron-3CDSENST00000502694ENST00000525449EPHA6chr3

96963131

-C11orf80chr11

66583524

+
intron-intronENST00000502694ENST00000527368EPHA6chr3

96963131

-C11orf80chr11

66583524

+
intron-3CDSENST00000442602ENST00000346672EPHA6chr3

96963131

-C11orf80chr11

66583524

+
intron-3CDSENST00000442602ENST00000360962EPHA6chr3

96963131

-C11orf80chr11

66583524

+
intron-3CDSENST00000442602ENST00000527634EPHA6chr3

96963131

-C11orf80chr11

66583524

+
intron-3CDSENST00000442602ENST00000540737EPHA6chr3

96963131

-C11orf80chr11

66583524

+
intron-3CDSENST00000442602ENST00000532565EPHA6chr3

96963131

-C11orf80chr11

66583524

+
intron-3CDSENST00000442602ENST00000525449EPHA6chr3

96963131

-C11orf80chr11

66583524

+
intron-intronENST00000442602ENST00000527368EPHA6chr3

96963131

-C11orf80chr11

66583524

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000389672EPHA6chr396963131-ENST00000346672C11orf80chr1166583524+24721644292377782
ENST00000389672EPHA6chr396963131-ENST00000360962C11orf80chr1166583524+27711644292488819
ENST00000389672EPHA6chr396963131-ENST00000527634C11orf80chr1166583524+25451644292488819
ENST00000389672EPHA6chr396963131-ENST00000540737C11orf80chr1166583524+25741644292485818
ENST00000389672EPHA6chr396963131-ENST00000532565C11orf80chr1166583524+25451644292488819
ENST00000389672EPHA6chr396963131-ENST00000525449C11orf80chr1166583524+24681644292377782

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000389672ENST00000346672EPHA6chr396963131-C11orf80chr1166583524+0.0026516490.9973483
ENST00000389672ENST00000360962EPHA6chr396963131-C11orf80chr1166583524+0.0026748570.99732506
ENST00000389672ENST00000527634EPHA6chr396963131-C11orf80chr1166583524+0.003656890.9963431
ENST00000389672ENST00000540737EPHA6chr396963131-C11orf80chr1166583524+0.0029593770.99704057
ENST00000389672ENST00000532565EPHA6chr396963131-C11orf80chr1166583524+0.003656890.9963431
ENST00000389672ENST00000525449EPHA6chr396963131-C11orf80chr1166583524+0.0027022480.9972977

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Fusion Genomic Features for EPHA6-C11orf80


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EPHA6-C11orf80


check button Go to

FGviewer for the breakpoints of chr3:96963131-chr11:66583524

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EPHA6

Q9UF33

.
FUNCTION: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity). {ECO:0000250}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEPHA6chr3:96963131chr11:66583524ENST00000502694-112331_4410335.0DomainFibronectin type-III 1
HgeneEPHA6chr3:96963131chr11:66583524ENST00000502694-11234_2120335.0DomainEph LBD
HgeneEPHA6chr3:96963131chr11:66583524ENST00000502694-112442_5370335.0DomainFibronectin type-III 2
HgeneEPHA6chr3:96963131chr11:66583524ENST00000502694-112631_9440335.0DomainProtein kinase
HgeneEPHA6chr3:96963131chr11:66583524ENST00000502694-112961_10250335.0DomainSAM
HgeneEPHA6chr3:96963131chr11:66583524ENST00000502694-1121034_10360335.0MotifPDZ-binding
HgeneEPHA6chr3:96963131chr11:66583524ENST00000502694-112637_6450335.0Nucleotide bindingATP
HgeneEPHA6chr3:96963131chr11:66583524ENST00000502694-11223_5500335.0Topological domainExtracellular
HgeneEPHA6chr3:96963131chr11:66583524ENST00000502694-112572_10360335.0Topological domainCytoplasmic
HgeneEPHA6chr3:96963131chr11:66583524ENST00000502694-112551_5710335.0TransmembraneHelical


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Fusion Gene Sequence for EPHA6-C11orf80


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000389672_ENST00000346672_TCGA-LL-A7SZ-01A_EPHA6_chr3_96963131_-_C11orf80_chr11_66583524_length(transcript)=2472nt_BP=1644nt
AAGTGAATAGTCCTCGCGCAAGCGGGACACTGTGGTGGATGCAATTCCCCTCGCCTCCAGCCGCGAGGAGCTCCCCGGCGCCGCAGGCAG
CGTCCTCCTCCGAAGCAGCTGCACCTGCAACTGGGCAGCCTGGACCCTCGTGCCCTGTTCCCGGGACCTCGCGCAGGGGGCGCCCCGGGA
CACCCCCTGCGGGCCGGGTGGAGGAGGAAGAGGAGGAGGAGGAAGAAGACGTGGACAAGGACCCCCATCCTACCCAGAACACCTGCCTGC
GCTGCCGCCACTTCTCTTTAAGGGAGAGGAAAAGAGAGCCTAGGAGAACCATGGGGGGCTGCGAAGTCCGGGAATTTCTTTTGCAATTTG
GTTTCTTCTTGCCTCTGCTGACAGCGTGGCCAGGCGACTGCAGTCACGTCTCCAACAACCAAGTTGTGTTGCTTGATACAACAACTGTAC
TGGGAGAGCTAGGATGGAAAACATATCCATTAAATGGGTGGGATGCCATCACTGAAATGGATGAACATAATAGGCCCATTCACACATACC
AGGTATGTAATGTAATGGAACCAAACCAAAACAACTGGCTTCGTACAAACTGGATCTCCCGTGATGCAGCTCAGAAAATTTATGTGGAAA
TGAAATTCACACTAAGGGATTGTAACAGCATCCCATGGGTCTTGGGGACTTGCAAAGAAACATTTAATCTGTTTTATATGGAATCAGATG
AGTCCCACGGAATTAAATTCAAGCCAAACCAGTATACAAAGATCGACACAATTGCTGCTGATGAGAGTTTTACCCAGATGGATTTGGGTG
ATCGCATCCTCAAACTCAACACTGAAATTCGTGAGGTGGGGCCTATAGAAAGGAAAGGATTTTATCTGGCTTTTCAAGACATTGGGGCGT
GCATTGCCCTGGTTTCAGTCCGTGTTTTCTACAAGAAATGCCCCTTCACTGTTCGTAACTTGGCCATGTTTCCTGATACCATTCCAAGGG
TTGATTCCTCCTCTTTGGTTGAAGTACGGGGTTCTTGTGTGAAGAGTGCTGAAGAGCGTGACACTCCTAAACTGTATTGTGGAGCTGATG
GAGATTGGCTGGTTCCTCTTGGAAGGTGCATCTGCAGTACAGGATATGAAGAAATTGAGGGTTCTTGCCATGCTTGCAGACCAGGATTCT
ATAAAGCTTTTGCTGGGAACACAAAATGTTCTAAATGTCCTCCACACAGTTTAACATACATGGAAGCAACTTCTGTCTGTCAGTGTGAAA
AGGGTTATTTCCGAGCTGAAAAAGACCCACCTTCTATGGCATGTACCAGGCCACCTTCAGCTCCTAGGAATGTGGTTTTTAACATCAATG
AAACAGCCCTTATTTTGGAATGGAGCCCACCAAGTGACACAGGAGGGAGAAAAGATCTCACATACAGTGTAATCTGTAAGAAATGTGGCT
TAGACACCAGCCAGTGTGAGGACTGTGGTGGAGGACTCCGCTTCATCCCAAGACATACAGGCCTGATCAACAATTCCGTGATAGTACTTG
ACTTTGTGTCTCACGTGAATTACACCTTTGAAATAGAAGCAATGAATGGAGTTTCTGAGTTGAGTTTTTCTCCCAAGCCATTCACAGCTA
TTACAGTGACCACGGATCAAGATGATTTGGTGCTTCCAGATGTGAGTTATCAGGTGGAATCCAGTGAGGAGGATCAGTCTCAGACTATGG
ATCCTCAAGGACAAACTCTGCTGCTTTTTCTCTTTGTGGATTTCCACAGTGCATTTCCAGTCCAGCAAATGGAAATCTGGGGAGTCTATA
CTTTGCTCACAACTCATCTCAATGCCATCCTTGTGGAGAGCCACAGTGTAGTGCAAGGTTCCATCCAATTCACTGTGGACAAGGTCTTGG
AGCAACATCACCAGGCTGCCAAGGCAGCTGACACACAAGAGTTCAGGACCAAACTGCACAAAGTATTTCGTGAGATCACCCAACACCAAT
TTCTTCACCACTGCTCATGTGAGGTGAAGCAGCAGCTAACCCTAGAAAAAAAGGACTCAGCCCAGGGCACTGAGGACGCACCTGATAACA
GCAGCCTGGAGCTCCTAGCAGATACCAGCGGGCAAGCAGAAAACAAGAGGCTCAAGAGGGGCAGCCCCCGCATAGAGGAGATGCGAGCTC
TGCGCTCTGCCAGGGCCCCGAGCCCGTCAGAGGCCGCCCCGCGCCGCCCGGAAGCCACCGCGGCCCCCCTCACTCCTAGAGGAAGGGAGC
ACCGCGAGGCTCACGGCAGGGCCCTGGCGCCGGGCAGGGCGAGCCTCGGAAGCCGCCTGGAGGACGTGCTGTGGCTGCAGGAGGTCTCCA
ACCTGTCAGAGTGGCTGAGTCCCAGCCCTGGGCCCTGAGCCGGGTCCCCTTCCGCAAGCGCCCACCGATCCGGAGGCTGCGGGCAGCCGT

>In-frame_ENST00000389672_ENST00000346672_TCGA-LL-A7SZ-01A_EPHA6_chr3_96963131_-_C11orf80_chr11_66583524_length(amino acids)=782AA_start in transcript=29_stop in transcript=2377
MWWMQFPSPPAARSSPAPQAASSSEAAAPATGQPGPSCPVPGTSRRGRPGTPPAGRVEEEEEEEEEDVDKDPHPTQNTCLRCRHFSLRER
KREPRRTMGGCEVREFLLQFGFFLPLLTAWPGDCSHVSNNQVVLLDTTTVLGELGWKTYPLNGWDAITEMDEHNRPIHTYQVCNVMEPNQ
NNWLRTNWISRDAAQKIYVEMKFTLRDCNSIPWVLGTCKETFNLFYMESDESHGIKFKPNQYTKIDTIAADESFTQMDLGDRILKLNTEI
REVGPIERKGFYLAFQDIGACIALVSVRVFYKKCPFTVRNLAMFPDTIPRVDSSSLVEVRGSCVKSAEERDTPKLYCGADGDWLVPLGRC
ICSTGYEEIEGSCHACRPGFYKAFAGNTKCSKCPPHSLTYMEATSVCQCEKGYFRAEKDPPSMACTRPPSAPRNVVFNINETALILEWSP
PSDTGGRKDLTYSVICKKCGLDTSQCEDCGGGLRFIPRHTGLINNSVIVLDFVSHVNYTFEIEAMNGVSELSFSPKPFTAITVTTDQDDL
VLPDVSYQVESSEEDQSQTMDPQGQTLLLFLFVDFHSAFPVQQMEIWGVYTLLTTHLNAILVESHSVVQGSIQFTVDKVLEQHHQAAKAA
DTQEFRTKLHKVFREITQHQFLHHCSCEVKQQLTLEKKDSAQGTEDAPDNSSLELLADTSGQAENKRLKRGSPRIEEMRALRSARAPSPS

--------------------------------------------------------------
>In-frame_ENST00000389672_ENST00000360962_TCGA-LL-A7SZ-01A_EPHA6_chr3_96963131_-_C11orf80_chr11_66583524_length(transcript)=2771nt_BP=1644nt
AAGTGAATAGTCCTCGCGCAAGCGGGACACTGTGGTGGATGCAATTCCCCTCGCCTCCAGCCGCGAGGAGCTCCCCGGCGCCGCAGGCAG
CGTCCTCCTCCGAAGCAGCTGCACCTGCAACTGGGCAGCCTGGACCCTCGTGCCCTGTTCCCGGGACCTCGCGCAGGGGGCGCCCCGGGA
CACCCCCTGCGGGCCGGGTGGAGGAGGAAGAGGAGGAGGAGGAAGAAGACGTGGACAAGGACCCCCATCCTACCCAGAACACCTGCCTGC
GCTGCCGCCACTTCTCTTTAAGGGAGAGGAAAAGAGAGCCTAGGAGAACCATGGGGGGCTGCGAAGTCCGGGAATTTCTTTTGCAATTTG
GTTTCTTCTTGCCTCTGCTGACAGCGTGGCCAGGCGACTGCAGTCACGTCTCCAACAACCAAGTTGTGTTGCTTGATACAACAACTGTAC
TGGGAGAGCTAGGATGGAAAACATATCCATTAAATGGGTGGGATGCCATCACTGAAATGGATGAACATAATAGGCCCATTCACACATACC
AGGTATGTAATGTAATGGAACCAAACCAAAACAACTGGCTTCGTACAAACTGGATCTCCCGTGATGCAGCTCAGAAAATTTATGTGGAAA
TGAAATTCACACTAAGGGATTGTAACAGCATCCCATGGGTCTTGGGGACTTGCAAAGAAACATTTAATCTGTTTTATATGGAATCAGATG
AGTCCCACGGAATTAAATTCAAGCCAAACCAGTATACAAAGATCGACACAATTGCTGCTGATGAGAGTTTTACCCAGATGGATTTGGGTG
ATCGCATCCTCAAACTCAACACTGAAATTCGTGAGGTGGGGCCTATAGAAAGGAAAGGATTTTATCTGGCTTTTCAAGACATTGGGGCGT
GCATTGCCCTGGTTTCAGTCCGTGTTTTCTACAAGAAATGCCCCTTCACTGTTCGTAACTTGGCCATGTTTCCTGATACCATTCCAAGGG
TTGATTCCTCCTCTTTGGTTGAAGTACGGGGTTCTTGTGTGAAGAGTGCTGAAGAGCGTGACACTCCTAAACTGTATTGTGGAGCTGATG
GAGATTGGCTGGTTCCTCTTGGAAGGTGCATCTGCAGTACAGGATATGAAGAAATTGAGGGTTCTTGCCATGCTTGCAGACCAGGATTCT
ATAAAGCTTTTGCTGGGAACACAAAATGTTCTAAATGTCCTCCACACAGTTTAACATACATGGAAGCAACTTCTGTCTGTCAGTGTGAAA
AGGGTTATTTCCGAGCTGAAAAAGACCCACCTTCTATGGCATGTACCAGGCCACCTTCAGCTCCTAGGAATGTGGTTTTTAACATCAATG
AAACAGCCCTTATTTTGGAATGGAGCCCACCAAGTGACACAGGAGGGAGAAAAGATCTCACATACAGTGTAATCTGTAAGAAATGTGGCT
TAGACACCAGCCAGTGTGAGGACTGTGGTGGAGGACTCCGCTTCATCCCAAGACATACAGGCCTGATCAACAATTCCGTGATAGTACTTG
ACTTTGTGTCTCACGTGAATTACACCTTTGAAATAGAAGCAATGAATGGAGTTTCTGAGTTGAGTTTTTCTCCCAAGCCATTCACAGCTA
TTACAGTGACCACGGATCAAGATGATTTGGTGCTTCCAGATGTGAGTTATCAGGTGGAATCCAGTGAGGAGGATCAGTCTCAGACTATGG
ATCCTCAAGGACAAACTCTGCTGCTTTTTCTCTTTGTGGATTTCCACAGTGCATTTCCAGTCCAGCAAATGGAAATCTGGGGAGTCTATA
CTTTGCTCACAACTCATCTCAATGCCATCCTTGTGGAGAGCCACAGTGTAGTGCAAGGTTCCATCCAATTCACTGTGGACAAGGTCTTGG
AGCAACATCACCAGGCTGCCAAGGCTCAGCAGAAACTACAGGCCTCACTCTCAGTGGCTGTGAACTCCATCATGAGTATTCTGACTGGAA
GCACTAGGAGCAGCTTCCGAAAGATGTGTCTCCAGACCCTTCAAGCAGCTGACACACAAGAGTTCAGGACCAAACTGCACAAAGTATTTC
GTGAGATCACCCAACACCAATTTCTTCACCACTGCTCATGTGAGGTGAAGCAGCAGCTAACCCTAGAAAAAAAGGACTCAGCCCAGGGCA
CTGAGGACGCACCTGATAACAGCAGCCTGGAGCTCCTAGCAGATACCAGCGGGCAAGCAGAAAACAAGAGGCTCAAGAGGGGCAGCCCCC
GCATAGAGGAGATGCGAGCTCTGCGCTCTGCCAGGGCCCCGAGCCCGTCAGAGGCCGCCCCGCGCCGCCCGGAAGCCACCGCGGCCCCCC
TCACTCCTAGAGGAAGGGAGCACCGCGAGGCTCACGGCAGGGCCCTGGCGCCGGGCAGGGCGAGCCTCGGAAGCCGCCTGGAGGACGTGC
TGTGGCTGCAGGAGGTCTCCAACCTGTCAGAGTGGCTGAGTCCCAGCCCTGGGCCCTGAGCCGGGTCCCCTTCCGCAAGCGCCCACCGAT
CCGGAGGCTGCGGGCAGCCGTTATCCCGTGGTTTAATAAAGCTGCCGCGCGCTCACCAAGTCCTCTTCCGCGTCTGCTTCCGCGTCGGGC
CCGGGCGGGGCGGGGCGGGGCGTGGAGCCGCGCCGCGGCCTGACGTCACCCACACCTCCCTGGGACTGCGTCACTGGTGCGCGCCGCGGG

>In-frame_ENST00000389672_ENST00000360962_TCGA-LL-A7SZ-01A_EPHA6_chr3_96963131_-_C11orf80_chr11_66583524_length(amino acids)=819AA_start in transcript=29_stop in transcript=2488
MWWMQFPSPPAARSSPAPQAASSSEAAAPATGQPGPSCPVPGTSRRGRPGTPPAGRVEEEEEEEEEDVDKDPHPTQNTCLRCRHFSLRER
KREPRRTMGGCEVREFLLQFGFFLPLLTAWPGDCSHVSNNQVVLLDTTTVLGELGWKTYPLNGWDAITEMDEHNRPIHTYQVCNVMEPNQ
NNWLRTNWISRDAAQKIYVEMKFTLRDCNSIPWVLGTCKETFNLFYMESDESHGIKFKPNQYTKIDTIAADESFTQMDLGDRILKLNTEI
REVGPIERKGFYLAFQDIGACIALVSVRVFYKKCPFTVRNLAMFPDTIPRVDSSSLVEVRGSCVKSAEERDTPKLYCGADGDWLVPLGRC
ICSTGYEEIEGSCHACRPGFYKAFAGNTKCSKCPPHSLTYMEATSVCQCEKGYFRAEKDPPSMACTRPPSAPRNVVFNINETALILEWSP
PSDTGGRKDLTYSVICKKCGLDTSQCEDCGGGLRFIPRHTGLINNSVIVLDFVSHVNYTFEIEAMNGVSELSFSPKPFTAITVTTDQDDL
VLPDVSYQVESSEEDQSQTMDPQGQTLLLFLFVDFHSAFPVQQMEIWGVYTLLTTHLNAILVESHSVVQGSIQFTVDKVLEQHHQAAKAQ
QKLQASLSVAVNSIMSILTGSTRSSFRKMCLQTLQAADTQEFRTKLHKVFREITQHQFLHHCSCEVKQQLTLEKKDSAQGTEDAPDNSSL
ELLADTSGQAENKRLKRGSPRIEEMRALRSARAPSPSEAAPRRPEATAAPLTPRGREHREAHGRALAPGRASLGSRLEDVLWLQEVSNLS

--------------------------------------------------------------
>In-frame_ENST00000389672_ENST00000527634_TCGA-LL-A7SZ-01A_EPHA6_chr3_96963131_-_C11orf80_chr11_66583524_length(transcript)=2545nt_BP=1644nt
AAGTGAATAGTCCTCGCGCAAGCGGGACACTGTGGTGGATGCAATTCCCCTCGCCTCCAGCCGCGAGGAGCTCCCCGGCGCCGCAGGCAG
CGTCCTCCTCCGAAGCAGCTGCACCTGCAACTGGGCAGCCTGGACCCTCGTGCCCTGTTCCCGGGACCTCGCGCAGGGGGCGCCCCGGGA
CACCCCCTGCGGGCCGGGTGGAGGAGGAAGAGGAGGAGGAGGAAGAAGACGTGGACAAGGACCCCCATCCTACCCAGAACACCTGCCTGC
GCTGCCGCCACTTCTCTTTAAGGGAGAGGAAAAGAGAGCCTAGGAGAACCATGGGGGGCTGCGAAGTCCGGGAATTTCTTTTGCAATTTG
GTTTCTTCTTGCCTCTGCTGACAGCGTGGCCAGGCGACTGCAGTCACGTCTCCAACAACCAAGTTGTGTTGCTTGATACAACAACTGTAC
TGGGAGAGCTAGGATGGAAAACATATCCATTAAATGGGTGGGATGCCATCACTGAAATGGATGAACATAATAGGCCCATTCACACATACC
AGGTATGTAATGTAATGGAACCAAACCAAAACAACTGGCTTCGTACAAACTGGATCTCCCGTGATGCAGCTCAGAAAATTTATGTGGAAA
TGAAATTCACACTAAGGGATTGTAACAGCATCCCATGGGTCTTGGGGACTTGCAAAGAAACATTTAATCTGTTTTATATGGAATCAGATG
AGTCCCACGGAATTAAATTCAAGCCAAACCAGTATACAAAGATCGACACAATTGCTGCTGATGAGAGTTTTACCCAGATGGATTTGGGTG
ATCGCATCCTCAAACTCAACACTGAAATTCGTGAGGTGGGGCCTATAGAAAGGAAAGGATTTTATCTGGCTTTTCAAGACATTGGGGCGT
GCATTGCCCTGGTTTCAGTCCGTGTTTTCTACAAGAAATGCCCCTTCACTGTTCGTAACTTGGCCATGTTTCCTGATACCATTCCAAGGG
TTGATTCCTCCTCTTTGGTTGAAGTACGGGGTTCTTGTGTGAAGAGTGCTGAAGAGCGTGACACTCCTAAACTGTATTGTGGAGCTGATG
GAGATTGGCTGGTTCCTCTTGGAAGGTGCATCTGCAGTACAGGATATGAAGAAATTGAGGGTTCTTGCCATGCTTGCAGACCAGGATTCT
ATAAAGCTTTTGCTGGGAACACAAAATGTTCTAAATGTCCTCCACACAGTTTAACATACATGGAAGCAACTTCTGTCTGTCAGTGTGAAA
AGGGTTATTTCCGAGCTGAAAAAGACCCACCTTCTATGGCATGTACCAGGCCACCTTCAGCTCCTAGGAATGTGGTTTTTAACATCAATG
AAACAGCCCTTATTTTGGAATGGAGCCCACCAAGTGACACAGGAGGGAGAAAAGATCTCACATACAGTGTAATCTGTAAGAAATGTGGCT
TAGACACCAGCCAGTGTGAGGACTGTGGTGGAGGACTCCGCTTCATCCCAAGACATACAGGCCTGATCAACAATTCCGTGATAGTACTTG
ACTTTGTGTCTCACGTGAATTACACCTTTGAAATAGAAGCAATGAATGGAGTTTCTGAGTTGAGTTTTTCTCCCAAGCCATTCACAGCTA
TTACAGTGACCACGGATCAAGATGATTTGGTGCTTCCAGATGTGAGTTATCAGGTGGAATCCAGTGAGGAGGATCAGTCTCAGACTATGG
ATCCTCAAGGACAAACTCTGCTGCTTTTTCTCTTTGTGGATTTCCACAGTGCATTTCCAGTCCAGCAAATGGAAATCTGGGGAGTCTATA
CTTTGCTCACAACTCATCTCAATGCCATCCTTGTGGAGAGCCACAGTGTAGTGCAAGGTTCCATCCAATTCACTGTGGACAAGGTCTTGG
AGCAACATCACCAGGCTGCCAAGGCTCAGCAGAAACTACAGGCCTCACTCTCAGTGGCTGTGAACTCCATCATGAGTATTCTGACTGGAA
GCACTAGGAGCAGCTTCCGAAAGATGTGTCTCCAGACCCTTCAAGCAGCTGACACACAAGAGTTCAGGACCAAACTGCACAAAGTATTTC
GTGAGATCACCCAACACCAATTTCTTCACCACTGCTCATGTGAGGTGAAGCAGCAGCTAACCCTAGAAAAAAAGGACTCAGCCCAGGGCA
CTGAGGACGCACCTGATAACAGCAGCCTGGAGCTCCTAGCAGATACCAGCGGGCAAGCAGAAAACAAGAGGCTCAAGAGGGGCAGCCCCC
GCATAGAGGAGATGCGAGCTCTGCGCTCTGCCAGGGCCCCGAGCCCGTCAGAGGCCGCCCCGCGCCGCCCGGAAGCCACCGCGGCCCCCC
TCACTCCTAGAGGAAGGGAGCACCGCGAGGCTCACGGCAGGGCCCTGGCGCCGGGCAGGGCGAGCCTCGGAAGCCGCCTGGAGGACGTGC
TGTGGCTGCAGGAGGTCTCCAACCTGTCAGAGTGGCTGAGTCCCAGCCCTGGGCCCTGAGCCGGGTCCCCTTCCGCAAGCGCCCACCGAT

>In-frame_ENST00000389672_ENST00000527634_TCGA-LL-A7SZ-01A_EPHA6_chr3_96963131_-_C11orf80_chr11_66583524_length(amino acids)=819AA_start in transcript=29_stop in transcript=2488
MWWMQFPSPPAARSSPAPQAASSSEAAAPATGQPGPSCPVPGTSRRGRPGTPPAGRVEEEEEEEEEDVDKDPHPTQNTCLRCRHFSLRER
KREPRRTMGGCEVREFLLQFGFFLPLLTAWPGDCSHVSNNQVVLLDTTTVLGELGWKTYPLNGWDAITEMDEHNRPIHTYQVCNVMEPNQ
NNWLRTNWISRDAAQKIYVEMKFTLRDCNSIPWVLGTCKETFNLFYMESDESHGIKFKPNQYTKIDTIAADESFTQMDLGDRILKLNTEI
REVGPIERKGFYLAFQDIGACIALVSVRVFYKKCPFTVRNLAMFPDTIPRVDSSSLVEVRGSCVKSAEERDTPKLYCGADGDWLVPLGRC
ICSTGYEEIEGSCHACRPGFYKAFAGNTKCSKCPPHSLTYMEATSVCQCEKGYFRAEKDPPSMACTRPPSAPRNVVFNINETALILEWSP
PSDTGGRKDLTYSVICKKCGLDTSQCEDCGGGLRFIPRHTGLINNSVIVLDFVSHVNYTFEIEAMNGVSELSFSPKPFTAITVTTDQDDL
VLPDVSYQVESSEEDQSQTMDPQGQTLLLFLFVDFHSAFPVQQMEIWGVYTLLTTHLNAILVESHSVVQGSIQFTVDKVLEQHHQAAKAQ
QKLQASLSVAVNSIMSILTGSTRSSFRKMCLQTLQAADTQEFRTKLHKVFREITQHQFLHHCSCEVKQQLTLEKKDSAQGTEDAPDNSSL
ELLADTSGQAENKRLKRGSPRIEEMRALRSARAPSPSEAAPRRPEATAAPLTPRGREHREAHGRALAPGRASLGSRLEDVLWLQEVSNLS

--------------------------------------------------------------
>In-frame_ENST00000389672_ENST00000540737_TCGA-LL-A7SZ-01A_EPHA6_chr3_96963131_-_C11orf80_chr11_66583524_length(transcript)=2574nt_BP=1644nt
AAGTGAATAGTCCTCGCGCAAGCGGGACACTGTGGTGGATGCAATTCCCCTCGCCTCCAGCCGCGAGGAGCTCCCCGGCGCCGCAGGCAG
CGTCCTCCTCCGAAGCAGCTGCACCTGCAACTGGGCAGCCTGGACCCTCGTGCCCTGTTCCCGGGACCTCGCGCAGGGGGCGCCCCGGGA
CACCCCCTGCGGGCCGGGTGGAGGAGGAAGAGGAGGAGGAGGAAGAAGACGTGGACAAGGACCCCCATCCTACCCAGAACACCTGCCTGC
GCTGCCGCCACTTCTCTTTAAGGGAGAGGAAAAGAGAGCCTAGGAGAACCATGGGGGGCTGCGAAGTCCGGGAATTTCTTTTGCAATTTG
GTTTCTTCTTGCCTCTGCTGACAGCGTGGCCAGGCGACTGCAGTCACGTCTCCAACAACCAAGTTGTGTTGCTTGATACAACAACTGTAC
TGGGAGAGCTAGGATGGAAAACATATCCATTAAATGGGTGGGATGCCATCACTGAAATGGATGAACATAATAGGCCCATTCACACATACC
AGGTATGTAATGTAATGGAACCAAACCAAAACAACTGGCTTCGTACAAACTGGATCTCCCGTGATGCAGCTCAGAAAATTTATGTGGAAA
TGAAATTCACACTAAGGGATTGTAACAGCATCCCATGGGTCTTGGGGACTTGCAAAGAAACATTTAATCTGTTTTATATGGAATCAGATG
AGTCCCACGGAATTAAATTCAAGCCAAACCAGTATACAAAGATCGACACAATTGCTGCTGATGAGAGTTTTACCCAGATGGATTTGGGTG
ATCGCATCCTCAAACTCAACACTGAAATTCGTGAGGTGGGGCCTATAGAAAGGAAAGGATTTTATCTGGCTTTTCAAGACATTGGGGCGT
GCATTGCCCTGGTTTCAGTCCGTGTTTTCTACAAGAAATGCCCCTTCACTGTTCGTAACTTGGCCATGTTTCCTGATACCATTCCAAGGG
TTGATTCCTCCTCTTTGGTTGAAGTACGGGGTTCTTGTGTGAAGAGTGCTGAAGAGCGTGACACTCCTAAACTGTATTGTGGAGCTGATG
GAGATTGGCTGGTTCCTCTTGGAAGGTGCATCTGCAGTACAGGATATGAAGAAATTGAGGGTTCTTGCCATGCTTGCAGACCAGGATTCT
ATAAAGCTTTTGCTGGGAACACAAAATGTTCTAAATGTCCTCCACACAGTTTAACATACATGGAAGCAACTTCTGTCTGTCAGTGTGAAA
AGGGTTATTTCCGAGCTGAAAAAGACCCACCTTCTATGGCATGTACCAGGCCACCTTCAGCTCCTAGGAATGTGGTTTTTAACATCAATG
AAACAGCCCTTATTTTGGAATGGAGCCCACCAAGTGACACAGGAGGGAGAAAAGATCTCACATACAGTGTAATCTGTAAGAAATGTGGCT
TAGACACCAGCCAGTGTGAGGACTGTGGTGGAGGACTCCGCTTCATCCCAAGACATACAGGCCTGATCAACAATTCCGTGATAGTACTTG
ACTTTGTGTCTCACGTGAATTACACCTTTGAAATAGAAGCAATGAATGGAGTTTCTGAGTTGAGTTTTTCTCCCAAGCCATTCACAGCTA
TTACAGTGACCACGGATCAAGATGATTTGGTGCTTCCAGATGTGAGTTATCAGGTGGAATCCAGTGAGGAGGATCAGTCTCAGACTATGG
ATCCTCAAGGACAAACTCTGCTGCTTTTTCTCTTTGTGGATTTCCACAGTGCATTTCCAGTCCAGCAAATGGAAATCTGGGGAGTCTATA
CTTTGCTCACAACTCATCTCAATGCCATCCTTGTGGAGAGCCACAGTGTAGTGCAAGGTTCCATCCAATTCACTGTGGACAAGGTCTTGG
AGCAACATCACCAGGCTGCCAAGGCTCAGCAGAAACTACAGGCCTCACTCTCAGTGGCTGTGAACTCCATCATGAGTATTCTGACTGGAA
GCACTAGGAGCAGCTTCCGAAAGATGTGTCTCCAGACCCTTCAAGCAGCTGACACACAAGAGTTCAGGACCAAACTGCACAAAGTATTTC
GTGAGATCACCCAACACCAATTTCTTCACCACTGCTCATGTGAGGTGAAGCAGCTAACCCTAGAAAAAAAGGACTCAGCCCAGGGCACTG
AGGACGCACCTGATAACAGCAGCCTGGAGCTCCTAGCAGATACCAGCGGGCAAGCAGAAAACAAGAGGCTCAAGAGGGGCAGCCCCCGCA
TAGAGGAGATGCGAGCTCTGCGCTCTGCCAGGGCCCCGAGCCCGTCAGAGGCCGCCCCGCGCCGCCCGGAAGCCACCGCGGCCCCCCTCA
CTCCTAGAGGAAGGGAGCACCGCGAGGCTCACGGCAGGGCCCTGGCGCCGGGCAGGGCGAGCCTCGGAAGCCGCCTGGAGGACGTGCTGT
GGCTGCAGGAGGTCTCCAACCTGTCAGAGTGGCTGAGTCCCAGCCCTGGGCCCTGAGCCGGGTCCCCTTCCGCAAGCGCCCACCGATCCG

>In-frame_ENST00000389672_ENST00000540737_TCGA-LL-A7SZ-01A_EPHA6_chr3_96963131_-_C11orf80_chr11_66583524_length(amino acids)=818AA_start in transcript=29_stop in transcript=2485
MWWMQFPSPPAARSSPAPQAASSSEAAAPATGQPGPSCPVPGTSRRGRPGTPPAGRVEEEEEEEEEDVDKDPHPTQNTCLRCRHFSLRER
KREPRRTMGGCEVREFLLQFGFFLPLLTAWPGDCSHVSNNQVVLLDTTTVLGELGWKTYPLNGWDAITEMDEHNRPIHTYQVCNVMEPNQ
NNWLRTNWISRDAAQKIYVEMKFTLRDCNSIPWVLGTCKETFNLFYMESDESHGIKFKPNQYTKIDTIAADESFTQMDLGDRILKLNTEI
REVGPIERKGFYLAFQDIGACIALVSVRVFYKKCPFTVRNLAMFPDTIPRVDSSSLVEVRGSCVKSAEERDTPKLYCGADGDWLVPLGRC
ICSTGYEEIEGSCHACRPGFYKAFAGNTKCSKCPPHSLTYMEATSVCQCEKGYFRAEKDPPSMACTRPPSAPRNVVFNINETALILEWSP
PSDTGGRKDLTYSVICKKCGLDTSQCEDCGGGLRFIPRHTGLINNSVIVLDFVSHVNYTFEIEAMNGVSELSFSPKPFTAITVTTDQDDL
VLPDVSYQVESSEEDQSQTMDPQGQTLLLFLFVDFHSAFPVQQMEIWGVYTLLTTHLNAILVESHSVVQGSIQFTVDKVLEQHHQAAKAQ
QKLQASLSVAVNSIMSILTGSTRSSFRKMCLQTLQAADTQEFRTKLHKVFREITQHQFLHHCSCEVKQLTLEKKDSAQGTEDAPDNSSLE
LLADTSGQAENKRLKRGSPRIEEMRALRSARAPSPSEAAPRRPEATAAPLTPRGREHREAHGRALAPGRASLGSRLEDVLWLQEVSNLSE

--------------------------------------------------------------
>In-frame_ENST00000389672_ENST00000532565_TCGA-LL-A7SZ-01A_EPHA6_chr3_96963131_-_C11orf80_chr11_66583524_length(transcript)=2545nt_BP=1644nt
AAGTGAATAGTCCTCGCGCAAGCGGGACACTGTGGTGGATGCAATTCCCCTCGCCTCCAGCCGCGAGGAGCTCCCCGGCGCCGCAGGCAG
CGTCCTCCTCCGAAGCAGCTGCACCTGCAACTGGGCAGCCTGGACCCTCGTGCCCTGTTCCCGGGACCTCGCGCAGGGGGCGCCCCGGGA
CACCCCCTGCGGGCCGGGTGGAGGAGGAAGAGGAGGAGGAGGAAGAAGACGTGGACAAGGACCCCCATCCTACCCAGAACACCTGCCTGC
GCTGCCGCCACTTCTCTTTAAGGGAGAGGAAAAGAGAGCCTAGGAGAACCATGGGGGGCTGCGAAGTCCGGGAATTTCTTTTGCAATTTG
GTTTCTTCTTGCCTCTGCTGACAGCGTGGCCAGGCGACTGCAGTCACGTCTCCAACAACCAAGTTGTGTTGCTTGATACAACAACTGTAC
TGGGAGAGCTAGGATGGAAAACATATCCATTAAATGGGTGGGATGCCATCACTGAAATGGATGAACATAATAGGCCCATTCACACATACC
AGGTATGTAATGTAATGGAACCAAACCAAAACAACTGGCTTCGTACAAACTGGATCTCCCGTGATGCAGCTCAGAAAATTTATGTGGAAA
TGAAATTCACACTAAGGGATTGTAACAGCATCCCATGGGTCTTGGGGACTTGCAAAGAAACATTTAATCTGTTTTATATGGAATCAGATG
AGTCCCACGGAATTAAATTCAAGCCAAACCAGTATACAAAGATCGACACAATTGCTGCTGATGAGAGTTTTACCCAGATGGATTTGGGTG
ATCGCATCCTCAAACTCAACACTGAAATTCGTGAGGTGGGGCCTATAGAAAGGAAAGGATTTTATCTGGCTTTTCAAGACATTGGGGCGT
GCATTGCCCTGGTTTCAGTCCGTGTTTTCTACAAGAAATGCCCCTTCACTGTTCGTAACTTGGCCATGTTTCCTGATACCATTCCAAGGG
TTGATTCCTCCTCTTTGGTTGAAGTACGGGGTTCTTGTGTGAAGAGTGCTGAAGAGCGTGACACTCCTAAACTGTATTGTGGAGCTGATG
GAGATTGGCTGGTTCCTCTTGGAAGGTGCATCTGCAGTACAGGATATGAAGAAATTGAGGGTTCTTGCCATGCTTGCAGACCAGGATTCT
ATAAAGCTTTTGCTGGGAACACAAAATGTTCTAAATGTCCTCCACACAGTTTAACATACATGGAAGCAACTTCTGTCTGTCAGTGTGAAA
AGGGTTATTTCCGAGCTGAAAAAGACCCACCTTCTATGGCATGTACCAGGCCACCTTCAGCTCCTAGGAATGTGGTTTTTAACATCAATG
AAACAGCCCTTATTTTGGAATGGAGCCCACCAAGTGACACAGGAGGGAGAAAAGATCTCACATACAGTGTAATCTGTAAGAAATGTGGCT
TAGACACCAGCCAGTGTGAGGACTGTGGTGGAGGACTCCGCTTCATCCCAAGACATACAGGCCTGATCAACAATTCCGTGATAGTACTTG
ACTTTGTGTCTCACGTGAATTACACCTTTGAAATAGAAGCAATGAATGGAGTTTCTGAGTTGAGTTTTTCTCCCAAGCCATTCACAGCTA
TTACAGTGACCACGGATCAAGATGATTTGGTGCTTCCAGATGTGAGTTATCAGGTGGAATCCAGTGAGGAGGATCAGTCTCAGACTATGG
ATCCTCAAGGACAAACTCTGCTGCTTTTTCTCTTTGTGGATTTCCACAGTGCATTTCCAGTCCAGCAAATGGAAATCTGGGGAGTCTATA
CTTTGCTCACAACTCATCTCAATGCCATCCTTGTGGAGAGCCACAGTGTAGTGCAAGGTTCCATCCAATTCACTGTGGACAAGGTCTTGG
AGCAACATCACCAGGCTGCCAAGGCTCAGCAGAAACTACAGGCCTCACTCTCAGTGGCTGTGAACTCCATCATGAGTATTCTGACTGGAA
GCACTAGGAGCAGCTTCCGAAAGATGTGTCTCCAGACCCTTCAAGCAGCTGACACACAAGAGTTCAGGACCAAACTGCACAAAGTATTTC
GTGAGATCACCCAACACCAATTTCTTCACCACTGCTCATGTGAGGTGAAGCAGCAGCTAACCCTAGAAAAAAAGGACTCAGCCCAGGGCA
CTGAGGACGCACCTGATAACAGCAGCCTGGAGCTCCTAGCAGATACCAGCGGGCAAGCAGAAAACAAGAGGCTCAAGAGGGGCAGCCCCC
GCATAGAGGAGATGCGAGCTCTGCGCTCTGCCAGGGCCCCGAGCCCGTCAGAGGCCGCCCCGCGCCGCCCGGAAGCCACCGCGGCCCCCC
TCACTCCTAGAGGAAGGGAGCACCGCGAGGCTCACGGCAGGGCCCTGGCGCCGGGCAGGGCGAGCCTCGGAAGCCGCCTGGAGGACGTGC
TGTGGCTGCAGGAGGTCTCCAACCTGTCAGAGTGGCTGAGTCCCAGCCCTGGGCCCTGAGCCGGGTCCCCTTCCGCAAGCGCCCACCGAT

>In-frame_ENST00000389672_ENST00000532565_TCGA-LL-A7SZ-01A_EPHA6_chr3_96963131_-_C11orf80_chr11_66583524_length(amino acids)=819AA_start in transcript=29_stop in transcript=2488
MWWMQFPSPPAARSSPAPQAASSSEAAAPATGQPGPSCPVPGTSRRGRPGTPPAGRVEEEEEEEEEDVDKDPHPTQNTCLRCRHFSLRER
KREPRRTMGGCEVREFLLQFGFFLPLLTAWPGDCSHVSNNQVVLLDTTTVLGELGWKTYPLNGWDAITEMDEHNRPIHTYQVCNVMEPNQ
NNWLRTNWISRDAAQKIYVEMKFTLRDCNSIPWVLGTCKETFNLFYMESDESHGIKFKPNQYTKIDTIAADESFTQMDLGDRILKLNTEI
REVGPIERKGFYLAFQDIGACIALVSVRVFYKKCPFTVRNLAMFPDTIPRVDSSSLVEVRGSCVKSAEERDTPKLYCGADGDWLVPLGRC
ICSTGYEEIEGSCHACRPGFYKAFAGNTKCSKCPPHSLTYMEATSVCQCEKGYFRAEKDPPSMACTRPPSAPRNVVFNINETALILEWSP
PSDTGGRKDLTYSVICKKCGLDTSQCEDCGGGLRFIPRHTGLINNSVIVLDFVSHVNYTFEIEAMNGVSELSFSPKPFTAITVTTDQDDL
VLPDVSYQVESSEEDQSQTMDPQGQTLLLFLFVDFHSAFPVQQMEIWGVYTLLTTHLNAILVESHSVVQGSIQFTVDKVLEQHHQAAKAQ
QKLQASLSVAVNSIMSILTGSTRSSFRKMCLQTLQAADTQEFRTKLHKVFREITQHQFLHHCSCEVKQQLTLEKKDSAQGTEDAPDNSSL
ELLADTSGQAENKRLKRGSPRIEEMRALRSARAPSPSEAAPRRPEATAAPLTPRGREHREAHGRALAPGRASLGSRLEDVLWLQEVSNLS

--------------------------------------------------------------
>In-frame_ENST00000389672_ENST00000525449_TCGA-LL-A7SZ-01A_EPHA6_chr3_96963131_-_C11orf80_chr11_66583524_length(transcript)=2468nt_BP=1644nt
AAGTGAATAGTCCTCGCGCAAGCGGGACACTGTGGTGGATGCAATTCCCCTCGCCTCCAGCCGCGAGGAGCTCCCCGGCGCCGCAGGCAG
CGTCCTCCTCCGAAGCAGCTGCACCTGCAACTGGGCAGCCTGGACCCTCGTGCCCTGTTCCCGGGACCTCGCGCAGGGGGCGCCCCGGGA
CACCCCCTGCGGGCCGGGTGGAGGAGGAAGAGGAGGAGGAGGAAGAAGACGTGGACAAGGACCCCCATCCTACCCAGAACACCTGCCTGC
GCTGCCGCCACTTCTCTTTAAGGGAGAGGAAAAGAGAGCCTAGGAGAACCATGGGGGGCTGCGAAGTCCGGGAATTTCTTTTGCAATTTG
GTTTCTTCTTGCCTCTGCTGACAGCGTGGCCAGGCGACTGCAGTCACGTCTCCAACAACCAAGTTGTGTTGCTTGATACAACAACTGTAC
TGGGAGAGCTAGGATGGAAAACATATCCATTAAATGGGTGGGATGCCATCACTGAAATGGATGAACATAATAGGCCCATTCACACATACC
AGGTATGTAATGTAATGGAACCAAACCAAAACAACTGGCTTCGTACAAACTGGATCTCCCGTGATGCAGCTCAGAAAATTTATGTGGAAA
TGAAATTCACACTAAGGGATTGTAACAGCATCCCATGGGTCTTGGGGACTTGCAAAGAAACATTTAATCTGTTTTATATGGAATCAGATG
AGTCCCACGGAATTAAATTCAAGCCAAACCAGTATACAAAGATCGACACAATTGCTGCTGATGAGAGTTTTACCCAGATGGATTTGGGTG
ATCGCATCCTCAAACTCAACACTGAAATTCGTGAGGTGGGGCCTATAGAAAGGAAAGGATTTTATCTGGCTTTTCAAGACATTGGGGCGT
GCATTGCCCTGGTTTCAGTCCGTGTTTTCTACAAGAAATGCCCCTTCACTGTTCGTAACTTGGCCATGTTTCCTGATACCATTCCAAGGG
TTGATTCCTCCTCTTTGGTTGAAGTACGGGGTTCTTGTGTGAAGAGTGCTGAAGAGCGTGACACTCCTAAACTGTATTGTGGAGCTGATG
GAGATTGGCTGGTTCCTCTTGGAAGGTGCATCTGCAGTACAGGATATGAAGAAATTGAGGGTTCTTGCCATGCTTGCAGACCAGGATTCT
ATAAAGCTTTTGCTGGGAACACAAAATGTTCTAAATGTCCTCCACACAGTTTAACATACATGGAAGCAACTTCTGTCTGTCAGTGTGAAA
AGGGTTATTTCCGAGCTGAAAAAGACCCACCTTCTATGGCATGTACCAGGCCACCTTCAGCTCCTAGGAATGTGGTTTTTAACATCAATG
AAACAGCCCTTATTTTGGAATGGAGCCCACCAAGTGACACAGGAGGGAGAAAAGATCTCACATACAGTGTAATCTGTAAGAAATGTGGCT
TAGACACCAGCCAGTGTGAGGACTGTGGTGGAGGACTCCGCTTCATCCCAAGACATACAGGCCTGATCAACAATTCCGTGATAGTACTTG
ACTTTGTGTCTCACGTGAATTACACCTTTGAAATAGAAGCAATGAATGGAGTTTCTGAGTTGAGTTTTTCTCCCAAGCCATTCACAGCTA
TTACAGTGACCACGGATCAAGATGATTTGGTGCTTCCAGATGTGAGTTATCAGGTGGAATCCAGTGAGGAGGATCAGTCTCAGACTATGG
ATCCTCAAGGACAAACTCTGCTGCTTTTTCTCTTTGTGGATTTCCACAGTGCATTTCCAGTCCAGCAAATGGAAATCTGGGGAGTCTATA
CTTTGCTCACAACTCATCTCAATGCCATCCTTGTGGAGAGCCACAGTGTAGTGCAAGGTTCCATCCAATTCACTGTGGACAAGGTCTTGG
AGCAACATCACCAGGCTGCCAAGGCAGCTGACACACAAGAGTTCAGGACCAAACTGCACAAAGTATTTCGTGAGATCACCCAACACCAAT
TTCTTCACCACTGCTCATGTGAGGTGAAGCAGCAGCTAACCCTAGAAAAAAAGGACTCAGCCCAGGGCACTGAGGACGCACCTGATAACA
GCAGCCTGGAGCTCCTAGCAGATACCAGCGGGCAAGCAGAAAACAAGAGGCTCAAGAGGGGCAGCCCCCGCATAGAGGAGATGCGAGCTC
TGCGCTCTGCCAGGGCCCCGAGCCCGTCAGAGGCCGCCCCGCGCCGCCCGGAAGCCACCGCGGCCCCCCTCACTCCTAGAGGAAGGGAGC
ACCGCGAGGCTCACGGCAGGGCCCTGGCGCCGGGCAGGGCGAGCCTCGGAAGCCGCCTGGAGGACGTGCTGTGGCTGCAGGAGGTCTCCA
ACCTGTCAGAGTGGCTGAGTCCCAGCCCTGGGCCCTGAGCCGGGTCCCCTTCCGCAAGCGCCCACCGATCCGGAGGCTGCGGGCAGCCGT

>In-frame_ENST00000389672_ENST00000525449_TCGA-LL-A7SZ-01A_EPHA6_chr3_96963131_-_C11orf80_chr11_66583524_length(amino acids)=782AA_start in transcript=29_stop in transcript=2377
MWWMQFPSPPAARSSPAPQAASSSEAAAPATGQPGPSCPVPGTSRRGRPGTPPAGRVEEEEEEEEEDVDKDPHPTQNTCLRCRHFSLRER
KREPRRTMGGCEVREFLLQFGFFLPLLTAWPGDCSHVSNNQVVLLDTTTVLGELGWKTYPLNGWDAITEMDEHNRPIHTYQVCNVMEPNQ
NNWLRTNWISRDAAQKIYVEMKFTLRDCNSIPWVLGTCKETFNLFYMESDESHGIKFKPNQYTKIDTIAADESFTQMDLGDRILKLNTEI
REVGPIERKGFYLAFQDIGACIALVSVRVFYKKCPFTVRNLAMFPDTIPRVDSSSLVEVRGSCVKSAEERDTPKLYCGADGDWLVPLGRC
ICSTGYEEIEGSCHACRPGFYKAFAGNTKCSKCPPHSLTYMEATSVCQCEKGYFRAEKDPPSMACTRPPSAPRNVVFNINETALILEWSP
PSDTGGRKDLTYSVICKKCGLDTSQCEDCGGGLRFIPRHTGLINNSVIVLDFVSHVNYTFEIEAMNGVSELSFSPKPFTAITVTTDQDDL
VLPDVSYQVESSEEDQSQTMDPQGQTLLLFLFVDFHSAFPVQQMEIWGVYTLLTTHLNAILVESHSVVQGSIQFTVDKVLEQHHQAAKAA
DTQEFRTKLHKVFREITQHQFLHHCSCEVKQQLTLEKKDSAQGTEDAPDNSSLELLADTSGQAENKRLKRGSPRIEEMRALRSARAPSPS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for EPHA6-C11orf80


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EPHA6-C11orf80


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneEPHA6Q9UF33DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
HgeneEPHA6Q9UF33DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
HgeneEPHA6Q9UF33DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational

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Related Diseases for EPHA6-C11orf80


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC11orf80C0678213Complete hydatidiform mole1ORPHANET